Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene
Contributor(s):
Cheng, Sheue-Yann
Sokoloff, Louis
National Cancer Institute (U.S.)
Nunez, Jacques
National Institute of Mental Health (U.S.)
Kaneshige, Masahiro
Suzuki, Hideyo
Proceedings of the National Academy of Sciences of the United States of America
Itoh, Yoshiaki
Esaki, Takanori
Cook, Michelle
Publication:
National Academy of Sciences (U.S.), 14 August 2001
The study demonstrated that in mice a targeted mutation of the TRα thyroid hormone receptor that prevents it from binding thyroid hormone results in the same retardation of body growth and maturation of local cerebral glucose utilization as seen in cretinism produced by neonatal thyroidectomy whereas a corresplnding mutation in the TRβ thyroid hormone receptor has no such effects. This study demonstrates that thyroid binding to the TRα thyroid hormone receptor and not at all to the TRβ receptor is critical to the normal maturation of the brrain.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
