Inappropriate antibiotic use, which includes prescribing drugs that are unnecessary, no longer necessary, or incorrectly dosed or using broad-spectrum agents when narrow-spectrum agents are appropriate for susceptible bacteria, is a national patient safety and public health concern. This practice perpetuates and exacerbates antibiotic resistance and contributes to conditions such as Clostridium difficile-associated diarrhea, as well as adverse drug effects and increased morbidity and mortality. According to the Centers for Disease Control and Prevention, as much as 50% of all antibiotics prescribed in acute care hospitals in the United States are unnecessary or inappropriate. In long-term care facilities, 49% to 62% of prescriptions are estimated to meet appropriate diagnostic criteria. Control of multidrug-resistant organisms in healthcare facilities requires attention to judicious antibiotic use through adoption of an antibiotic stewardship program. Results of Pennsylvania Patient Safety Authority surveys of Pennsylvania acute care hospitals and long-term care facilities include opportunities for improvement in all facets of antibiotic stewardship and indicate facility interest in learning more about antibiotic stewardship and participating in a statewide or regional collaboration to support antibiotic stewardship programs. This article outlines strategies for identifying existing gaps in antibiotic stewardship programs and presents strategies for instituting or enhancing antibiotic stewardship programs in acute and long-term care facilities.
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