Excerpt from Donald S. Fredrickson's diary on the exemption of E. coli experiments from the NIH Guidelines for Research Involving Recombinant DNA Molecules
In the revised NIH guidelines for recombinant DNA research released in January 1979, containment requirements for experiments with Escherichia coli (E. coli) strain K-12, the most commonly-used host-vector system in recombinant DNA research, were greatly eased. This reflected a growing realization that experiments during which foreign DNA fragments were inserted into this strain of E. coli did not present the environmental hazards earlier feared by scientists.
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