In the late 1970s and early 1980s, some researchers began to question the use of certain diuretics as antihypertensive agents, reasoning that they could cause hypokalemia and therefore increase the likelihood of cardiac arrhythmias. In this small study of patients with diuretic-induced hypokalemia, Freis's team found no evidence that the reduction of hypokalemia would reduce the incidence of cardiac arrhythmias, suggesting no link between the two phenomena.
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