This draft to the Patent and Trademark Office summarizes the history of the NIH Office of Technology Transfer activities and recent work on policy issues. When PTO announced that expressed sequence tags (ESTs) were patentable research tools in 1997, Varmus expressed concern about the effects of such patents on research. The National Academy of Sciences got involved in this dialogue, sharing Varmus's concerns about the possible broad scope of EST patents. This draft is a good example of the complex legal and commercial aspects of molecular biology research.
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