Synapse Turnover: A Mechanism for Acquiring Synaptic Specificity
Contributor(s):
Thompson, Jeffrey M.
Eisenbarth, George S.
Ruffolo, Robert R.
Nirenberg, Marshall W.
Proceedings of the National Academy of Sciences of the United States of America
In previous studies on synapse formation, "chick embryo retina neurons were shown to form synapses rapidly with striated muscle cells" but were transient and eventually disappeared. This report uses striated muscle cells to define the number of neurons that are able to form synapses at different stages of development and suggests that both correct and incorrect synapses are formed during normal embryonic development, with correctly matched synapses being retained.
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