Approximation of Genetic Code Via Cell-Free Protein Synthesis Directed by Template RNA
- Contributor(s):
- Nirenberg, Marshall W. Federation Proceedings Barondes, Samuel H., 1933- Martin, Robert G. Jones, Oliver W., Jr Matthaei, Heinrich
- Publication:
- Federation of American Societies for Experimental Biology, [January-February 1963]
- Language(s):
- English
- Format:
- Text
- Subject(s):
- DNA RNA RNA, Messenger
- Genre(s):
- Archival Materials Articles
- Abstract:
- This article offers a solution to the technical problems of a direct biochemical approach to deciphering the genetic code. Comparison of the nucleotide sequence of a gene with the amino acid sequence of its corresponding protein remained problematic as the sequence of nucleotides in each coding was initially unknown. The authors demonstrate with experimental evidence that there are only a certain number of possible nucleotides per code word. Additionally, by using tobacco mosaic virus RNA to direct the cell-free synthesis of a protein resembling TMV, the experiment suggests at least part of the genetic code appears to be universal.
- Copyright:
- This item may be under copyright protection; contact the copyright owner for permission before re-use.
- Extent:
- 7 pages
- NLM Unique ID:
- 101584910X133 (See in Profiles in Science)
- Profiles in Science ID:
- JJBBJJ
- Permanent Link:
- http://resource.nlm.nih.gov/101584910X133
- Archival Collection:
- The Marshall W. Nirenberg Papers (Profiles in Science)