Like Paul Berg, Singer criticized Sinsheimer for undertaking what Singer and Berg considered recombinant DNA experiments in his laboratory at the California Institute of Technology, while at the same time dismissing the recently-issued NIH guidelines on rDNA research as inadequate and calling for broader restrictions on the new technology. Their exchange expressed the uncertainties over the environmental and health safety of recombinant DNA research at a time when there was little empirical data on hand and regulation had to be based on an assessment of risk.
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