Letter from Arthur Kornberg to Robert L. Sinsheimer
Contributor(s):
Sinsheimer, Robert
Kornberg, Arthur, 1918-2007
California Institute of Technology
Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to a double helix after entering its E. coli host, and the double stranded form was by itself infective. In this letter, Kornberg asked for a sample of Sinsheimer's virus to start investigating its possible use as a replication template. It was from this virus that Kornberg was able to create an infective synthetic viral DNA in 1967.
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