The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: I. Distribution of the Reactive Protein in Patients' Sera and the Effect of Calcium on the Flocculation Reaction with C Polysaccharide of Pneumococcus
Contributor(s):
Avery, Oswald Theodore, 1877-1955
Abernethy, Theodore J.
Journal of Experimental Medicine
After detecting a new protein, the "C-reactive protein," in the serum of pneumonia patients, Avery and Abernethy set out to investigate what they believed to be an aspect of the infectious process that transcended the classic antigen-antibody reactions. Over the course of three papers in 1941, Avery and Abernethy, and later Avery and Colin MacLeod, defined the characteristics of the protein and established that it was not an antibody. They cited evidence that the protein was instead released from tissue, likely as a result of cellular damage, and thus was a product of some nonspecific reaction of tissue to injury.
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