Healthcare practitioners may underestimate the exposure risk associated with hazardous drugs. The risk of exposure extends along the drugs' entire life cycle, including the manufacturing, transporting, dispensing, and administering processes. The safe handling of hazardous drug spills is uniquely different from other healthcare spills, and exposure extends beyond patients and healthcare practitioners because nonclinical staff are often involved with the containment and disposal of spills. PA-PSRS has received more than 40 reports of patients and staff exposure to hazardous drugs. Many events involved intravenous (IV) tubing disconnections resulting in hazardous drugs leaking to the floor, the patient, hospital gowns, and linens. Many exposure incidents were attributed to IV port or site leaks and involved IV spiking issues, resulting in large hazardous spills. Risk reduction strategies include developing a hazardous drugs program; encouraging personnel compliance in the storing, dispensing, transporting, and administering of these medications; managing spills; and disposing of hazardous drugs in such a way that the most appropriate guidelines are used to minimize exposure.
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