Yellow Fever FACTS, AS TO ITS Nature, Prevention and Treatment BY JOHN B. C. GAZZO, M. D., PARISH OF LAFOURCHE, LA., 1878. \*j >*) their virulence, for the pabalum of all infections. Complaints is found to exist in the mephitic air of low, moist, closed and narrow streets and shut up retreats, where these are crowding, bad ventilation and the invariable accompainments of poverty and drunkeness ; add to these, impure water, and there is all that is requisite to breed sickuess aud to invite and arrest yellow fever in its prevalence. Ships should be inspected on approaching ports, because they may have unsanitary conditions intensified in them, on a scaie sufficiently to be important. This should be a part of sanitary police, nor should iuclude any restriction of persons, at the most, louger than enough for cleansing of the body and of the clothing, and purification of merchandise by fresh air and possibly by some disinfecting process in certain cases. A careful sanitary police, hence the absolute necessity for systematic sanitary visitation of the dwellings of the poor, and the yards, courts and alleys wich they inhabit; such as of late exist in certain cities, as in Canada and Great Britain, and which can be effectually carried out only in the appointment of " Inspectors of Nuisances," by able aud intelligent men, which includes the protection of available measures for the preven- tion, and obviating the development aud extension of the disease in any place. On this ground the sanitary precautions are not many, nor always difficult of observance, but they are imperative and commonly very effectual aud to be relied upon with confideuce, aud are familiar. Thorough and frequent cleansing of all streets, alleys, yards, wharves and vessels, private and public buildings and empty lots, the abatement of all nuisance, daily removal of offal, efficient sewerage, etc. The emanations from privies are always offensive aud injurious to health, particularly in close, pent-up yards ; even the best constructed water closets are not at all free from objection. The cleansing, ventilation and disinfection of cess-pools and water closets among all signs of danger of the location of yellow fever, none is more signifi- cant than the privy odor. Let it be everywhere annihilated. Lime, charcoal, dry earth, chloride of lime, liquid coal tar, chloride of zinc, sulphate of iron aud carbolic acid, are about the most available of disinfectants. The uext point of import- ance that may be used to correct foul smells, yet it must not be forgotten that they do not entirely destroy the noxious effects of the effluvia, the shoot, which ii an excellent deodorizer of every house, should be collected, to be strewu occasionally into the privies and water closets. The floors of the dwellings should be well scrubbed with lie or chloride of soda at least once a week, and thorough ventila- tion, every tenement should be supplied with abundance of good water. That from wells in ordinary yards is always more or less impure and is frequently most injurious, being saturated with all the fifth that soaks through the earth from the privies. 23 Chloride of lime or carbolic acid may be placed in a plate in any suspected rooms or other locality in a house during the prevalence of yellow fever. Lime, dried pulverized plaster of paris, mixed with rather more than one-fifth its weight of pow- dered charcoal is a cheap disinfecting compound, may be thrown every three days on the floors or any other places. It entirely removes the noxious emanations from decomposing organic bodies and matters, especially in case of the patients with the disease. Every vessel used may and should be disinfected constantly by a diluted solution of chloride of zinc ore, Sir Wm. Burnett's disinfecting fluid; yet it is very manageable aud efficient that every house should be supplied with a little of this fluid, to which there is always attached clear directions for its use. The immediate removal of all discharges from the sick room, their disinfectionand transportation to the safest possible place of elimination, oughtfco be im- peratively maintained. All foul bed apparel aud clothes must be promptly washed, or if very bad, disinfected These pre - cautions have been proved to be capable of essentially limiting and mitigating the prevalence of epidemic fevers. Therefore, internal sanitary arrangements and no quarantine and sanitary Hues are the safeguards of uations against epidemic diseases. What is very good to cast into cess-pools aud drains, some of the black amraonical liquor which is antiseptic and disin- fectant, that abounds in the New Orleans aud Jefferson gaslight factories, and also the lime that is served for the purifying of the gas is very useful in destroying noxious odors. All holes and cavities about dwellings should be tilled with old mortar, ashes aud lime from the New Orleans gas factories, which seem to be eveu better deodorizers than fresh lime. All three sub- stances are excellent disiufectauts, and instead of being con- verted into nuisances in the streets, should be used in the man- ner indicated, by which they would become useful and be sought after. Epidemics are sure to alight where terrestial emauations of a mephitic nature exist. In cities and towns it has almost always been the lowest, most crowded aud most filthy sections that have suffered most. Where there is not a free circulation of air, aud where the cheering breeze of the wind seldom penetrates, these localities are always raw and chilly, aud there is constantly a very per- ceptible repulsive aud musty odor, and the inhabitants are pale, " Fievre lentev and debilitated, and the utmost care should be ob- served to obtain perfect ventilation. Whilst impure aud con- fined air in crowded apartments or rooms is always deleterious, it is eminently so iu times of yellow fever and during the preva- lence of all epidemic diseases. The breathing of foul air predis- poses to every disease, enervates the body and destroys all moral and physical energy. The fire-places and wiudows should be kept open, and every room have, if possible, an open- iuto the chimney near the ceiling for the escape of the heated 24 and deteriorated air. A fire should be kindled for the double purpose of imparting ventilatiou and causing a draught in the house. TREATMENT OF YELLOW FEVER. The investigation of the nature of Yellow Fever continues in all parts of the world, but as yet with no positive results. I have endeavored by patient examination to arrive at some conclusion from the various statements made by learned men, but in vain. All that the most careful dissections have taught us is that there is uo invariable or essential doctrine of the en- demic. Only one thing certain has been found out,—that there is an alteration of the blood within the body. Thus in the se- rum of the blood which loses one third of its fibrine and brings forth a considerable diminution of chyle and propagates a very large excess of nitrogeu and hydrogen in the circulation; whether these changes are primary or secondary no oue can tell. Therefore I may assert that all the changes of these causes might be owing to the defalcation of its alkalies as being the proper agents to maintain and to hold in the state of the process of its nutriments, which nutrition of the body is dependent.upon the healthy action of the alimentary organs, which effects indicate a continual presence of bilious action, but actually produces a morbid alteration in the blood before it induces fever. This exciting disorder is due to the amount of alkalies wasted in the chyle and are due to the increased excretion of urea and phosphates from the kidneys. The most formidable affectiou presenting itself in the stom- ach and intestines of yellow fever patients, is that in which we have a congested, yet weakened aud atonic state of the mucous membraue. Hemorrhage, and more mucous irritation precede this condition, and after a time we have gaseous motorism of the intestines. The abdomen is distended aud fiud tympanitic sound on percussions. This distension of the intestines is a source of distress in two forms, firstly, from the accumulation of air in the stomach and bowels themselves; and next from interference with the process of respiration. The desceut of the diaphragm being impeded and prevented by the swollen state of the iutestiues, we often find in connectiou with this state an irritation of'the gastric membrane of the stomach, such that the patient rejects a portion of almost everything that is swallowed. There is at the same time an irritable action of the kidneys, when elimination is defective, leading to accumulated excretions and with retention of uriue, or with the discharge of only small quantities of it. Under these circum- stances drink aud medicines accumulate iu the intestinal tract, while gases are generated in excess. The absorbent powers of the mucous surfaces seem for a time to be in abeyance, while the muscular fibres are loss of voluntary motion and the 25 stomach and intestines seem incapable of freeing themselves of their matters by peristaltic or anti-peristaltic. There can be but little doubt that the state above described is one often brought on by the injudicious use of medicines. Very cold water and farrago of substances supposed to be proper or use- ful in the sick room ; the injudicious use of mercurial drastics or saline purgatives at the outset of the fever, leads in some instances to hypercathasis within. W7e still have to apprehend an atonic state of the muscular coats of the stomach and its re- sults as above described. The excessive and rather abuse of cold iced driuks and fruits and all the other stimulating slops supposed to be necessary or good to the yellow fever patient, couduce to a like effect. This irregular and nervous stage is always to be regarded as a formidable complication and state in the yellow fever aud when developed to an extreme degree and persisting for two or three days resisting treatment, it is an indication of all but fatal consequences. The fever, seizing with peculiar violence upon the organs of the secretions, and especially upon those which belong to the digestive operations, hence the liver will suddenly pour forth an immense flow of bile, so vitiated in quality as to irritate and inflame whatever it touches, and so abundant in quantity as rapidly to diffuse itself over every part of the body, and to tinge every tissue and every fluid at the same time; the stomach and the intestines may be involved in such acute fever that the power of life may be exhausted in a few hours, by incessant vomiting. That there is from the beginning a great prostration of strength and a rapid increase in the derangement of the nervous and sensorial functions, together with a brown tongue aud dark and offensive stools, which show the contiuual presence of the exciting bile, which, but actually produces a morbid alteration within the blood before it induces febrile heat to high degree. The death in yellow fever by mecurializing patieuts out of the world, is all wrong and pernicious; never meddle with the stomach and other functions; which we learn from Sir John Gilpin of the British army, and Dr. P. C. A. Louis in the epidemics of yellow fever in Spain—the stomach is the " throne of yellow fever," and if in undisturbed state, left in perfect repose in that stage, will not throw up black vomit. But all this is too plain perhaps, for the utera preseribers in mineral and vegetable poisons, too uusophistieal for mysterious dogmas of charlatans. Dr. Hosack, of New York, was laughed at for piaisihg castor oil and catnip tea, the humble instruments by which the quaker physician, Dr. B. Underbill, cured so many persons in one of the worst scourges of yellow fever in Phila- delphia. Soon as the patient is attacked, put him in a warm bath in which two drachms of strong sulphuric acid, has been dissolved 4 26 to each gallon of water; the patient remains in the bath a quarter oV half an hour and is afterwards wrapped in a cotton sheet and sponged with the same fluid as that which forms the bath, every two or three bonis; this procedure or mode of treatment/which seems to act through the blood in inducing diaphoresis, and theu by lessening at the outlet the primary febrile paroxysm. n . t . .. The indications for the employment of curative agents in the form of fever are furnished by the state of the suffering orgau; the skin, which is hot and acrid, and the mucous membrane require to restore their appropriate secretory and absorbing functions, aud the glands to their secretory aud depuratory office. . , . Ou the skin we should act at once by means of cool air aud by immersion in a sulphuric acid bath, has been attended with excellent effect by often arresting the fever in its first stage, and by greatly mitigating the violence and gravity ot the . symptoms in its progress, iu which the capillaries are iu a state of morbid excitement and largely evolve by heat; at the same that the breathing is labored and the brain oppressed, a sul- phuric acid bath rouses the nervous system from its torpor and restores the respiration to its former state. According to the predominance of excitement in an organ or region—as, at one time of the head,at another of the epigastric region—which will be the special direction of the refrigerant applications to the head; aud I have used with marked benefit the following lotion, to be applied to the epigastric region, head and over the abdomeu; the febrile part of which, indeed, is often very excessive in yellow fever. R. Liquor Soda Chlorinata, "Labarraque," Iviij. Sp. Lavandula, 3"j. Sp. Kosemarini, 3v. Soda boras, Iss. Add two pints of cold water to the above formula, Directions: Wet a piece of cotton cloth three or four in thickness, sufficiently large to cover the epigastric region aud abdomen ; should be re-applied every time when dry in order to maintain an equalization of the temperature in the body and proper distribution of circulation. The temperature of the pa- tient should not be allowed to run^above 103° or 104° Fahren- heit. Usually the temperature may be kept withiu this range by means of the above application, aud the patient will press with evidence of pleasurable sensations of the lotion on his epigastrique and ask for a renewal of them. If remission or retirement of fever and perspiration has been attained, sulphate of quinine in ten grain doses, every two hours, until its effects ou the nervous system aud circulation is fully obtained through the normal temperature, which consists in not allowing the temperature to rise above the regular stand- 27 ard. If it does it is at once lowered by the sulphuric acid baths and topical means which this will arrest the rapid repro- duction and keep down the excessive burning heat within the body. Under the supposition that our patient is laboring with com- pletely formed fever and is in that stage in which professional assistance is commonly wanted in the forming or preliminary stage of the yellow fever, that iu which the nervous system is the part chiefly affected and in which the temperature of the surface is unequal, the patient at one hour shivering, at another complaiuing of too much heat. A warm hip or foot bath in which has been dissolved a considerable quantity of chloride of lime, this bath must be continued until the patient per- spires when given; these baths have uo other advantage than that of purifying the atmosphere of the room, and will prove to be soothing and salutary, and may, if its operation be aided by simple drinks, such as elder flower tea, orange leaf tea or flower tea, to bring on diaphoresis or produce perspiration, which will restore the skin to its natural state and contribute to an equalizing of other deranged fuuctions. It is important to bear in mind the fact that the salutary change which is brought about in the capillary circulation and secretions of the skin, are responded to in a similar sense by the gastroenteric and pul- monary mucous membrane. The thirst, dryness aud heat of the mouth and face, and the gastric sensation of heat, are all greatly mitigated after a chloride of lime bath, aud, in combi- nation with the refreshing lotion on the whole body of the patient; the breathing also is freer, and the expired air less hot and offensive. Various means have been proposed and recommended to calm the stomach. Leeches and cups to the epigastrium, in cases where they are admissible, have occasionally been found bene- ficial. The physician must watch the efforts of nature aud pro- mote any critical movement she may- indicate. The most alarming symptoms in this fever is irritability of the stomach, and in many instances associated with vomiting. It is apt to be present and so often uncontrollable that it is of importance to indicate remedies to check them. When the gastric juice is about changing or deriorating in the stomach, there is a burn- ing sensation, is generally relieved by the use of chlorate of potassium, super-carbonate of soda or lime water. I have gen- erally succeeded with the following prescription, viz.: ft Acid citric |ss. Sub. carb. amon. 3ij. and when the efferveseuce has ceased, add simple syrup, two ounces ; camphor water, one ounce. Give one tablespoouful every half hour or two hours, accord- ing to the attack, and for the excessive nausea aud efforts to vomit in the gastric disturbance, a mixture which acts quite promptly. 28 R Chlorate hydrat ?j. Potassa bi-carbonate ~ij. Spt. Chloroform ~;iij. Syr. Tolu oijss. Aqua' camphora 5J. one teaspoouful every half hour or half a tablespoouful every hour, if this mixture do not suppress vomiting, you may have recourse to the following preparation to check vomiting. R Bromide potassa, 3ij Syr. zinzileris. Tiuct. opii. camp. aa. ti. 3 ij Dose.—Give one teaspoouful every half hour, or each time after the patient vomits. Or, the following prescription of Bromide, after the more decided iu the depress powers of life, and prevent the tendency to collapse: R Bromide potassa, jj Syr. zingeb. fl. 5) Sr. meuth. pip. 'iij Chloroform, Jj One teaspoouful every two or three hours. We must continue by the use of purgatives, elimination of matter from digestive organ, which was begun by the efforts of vomiting. In the inception of the fever, by this treatment we remove some of the probable causes, aud abate, if not dissi- pate, some of the obvious troublesome symptoms in the first formed stage of yellow fever in milder eases. This is ofteu alone sufficient to check the farther progress of the disease and to bring on couvalesence. Whether we suppose t.hat there is a morbid excitement which required subduing, or an effusion which ought to be eliminated, we are fortified in acting ou the stomach aud intestines in the manner already mentioned. If we do not thereby cure, we, at least, diminish the probabilities of further injury. By the acid sulphuric aud chloride of lime bath, aud the continued applicatiou of refrigerants, lotions, externally, we abate the excessive fever or burning heat, itself a disturbing cause both to the nervous and circulation of the sanguine systems aud we rouse the patient from the delirium to which he had been thrown by the workings of malaria on the brain aud other organs aud functions of the body. R Spirit aetheris nitrosi, fj Citrat potassa, ^ij Liquor ammonia acet, ^iij Soda et potassa tart. |iij Aqua rosa, ^xij Two tablespoonful every half-hour or four tablespoouful ever> two hours, according to the case, and to be given iu the l'uvei at its highest warm stage, or exacerbation of the fever. I have therefore, so also employed the boracic acid as 29 means of prevention in the incipient stage of mortification, and the sedative action which retain its efficacy for a long time as antiseptic agent, aud remedy in doses of from six to ten grains or more as a corrective of bilious putrefactious. The Geneva medical papers, say that Prof. Scbiff, formerly of Rome, Italy, has discovered an infallible remedy, in the salicylic acid, as a prevention of putrefaction chauges in febrile cases, and assimilated as a sedative. All reports agree that fifteen or twenty grains of salicylic acid per day may be taken without any notable disturbance or alteration of the alimentary canal. An invalid of yellow fever must be treated like a child. He must be kept entirely under control; it is a safe rule to follow, to do for the patient precisly opposite to what the latter wishes, or what he does. If he is thirsty, a piece of ice may safely be placed at intervals in his mouth, which is better to allay the heated thirst, is to place around the neck a piece of musliu saturated in cold water. His excessive thirst must be restrained by four or six tablespoonfuls of lemonade or cold water after being boiled, at some intervals; should he throw off his bed coverings, it will be found that his extremities are cold, aud that the cir- culation must be equalized by warm or hot chloride of lime foot bath and keep them well covered to induce perspiration, then to place at intervals on the forehead a cloth saturated in cold water, and if he requires the unremitting aid of external topical applications and sponging iu ablutions constantly with Louisiana Rum, diluted with lime juice and with cologne water, and lavements when necessary, specially if much fever and headache, every two or three hours, with a decoc- tion of flaxseed or okra. (Hibiscus Exculentin.) If he is dis- posed to coma rigid, or to be watchful, invite him to sleep, by fanniug, and by the frequent passage of cologne moistened cloth on the forehead aud temples; if too much prone to sleep, enliveu him with such subjects only as will not create excite- ment, by inducing too much though fullness iu a word. The deceitfulness of symptoms to the physician and patient is a characteristic feature of the yellow fever, creating desires and" wishes iu the patient almost always antagonistic to his well-beiug. Strict attention to the diet of the patient is not less impor- tant in the successful management of the fever. In the early- stages it should be very light, consisting chiefly of liquid substances, solutions of gum arabic, rice water, orange leaf tea, tost water, preserved jellies mixed with water, and similar preparations may be successively or iuterchangably employed; cold lemonade or orangade and pure rain water in moderation may also be used as drinks in the hot stage of fever, at a more advanced period, after five or six days for example, wheu the symptoms of debility begin to show themselves, it will be 30 necessary to support the strength by a more nutritive diet, which, however, should not be stimulating. Preparations of rice or arrow-root of a nearly gelatinous consistence, thick gruel or panada, may new be given, flavored with nutmeg or other spice, and sugar, etc. It will often be desirable to give these in certain quantities at certain intervals, so as to insure that enough is taken. I have generally been in the habit of directing that a cupfull be given every two or three hours, or less frequent, according to the apparent strength of the patient. A cup of tea may also be allowed with dry toast or water crackers, morning and eveuing; still further on in the stage of the fever, milk in small quantities, frequently repeated, will be often found to suit the case admirably well; two table- spoonfuls of it may be giveu every hour or two through the day, and if the stomach be irritable, it may very properly be associated with one-third quantity of lime water. In the last or prostrate stage it is proper that the diet should not only be nutritive, but also stimulating; animal broths and chicken soup may now be given, aud in lowest cases it is necessary to resort to egg, beat up with wine, milk punch with Jamaica rum, and essence of beef or mutton throughout the whole case. The greatest attention should be paid to cleanliness and venti- lation, and when the atmosphere cannot be sufficiently purified by these means, as sometimes happens when many patients are crowded together, recourse may be had to the corrective influence of the chloric ether lamp in purifyiug it. One parting word may properly be added on the subject of the treatment of yellow fever. It is important that the public should understand that the disease has definite minimum direction, which nothing can alter. That her natural tendency is, on the whole, to a favorable termination, and that the best and most enlightened physicians are the most fairly convinced that there exists uo practical means of shortening the natural term of this malady. Therefore, when I speak of treatment by medical attention, I mean no more than this, that the interference of a vigilant and skilful physician, frequently prevests the patieut from sinking under the disease, before it has run its natural course and averts some of those evil con- sequeuces which are apt to follow when the patieut was pre- viously iu delicate health or was affected with latent tendencies to constitutional disease. It is perhaps, a matter of doubt, whether the erroneous popular notion ou this point, which attribute to the skilful physician the power of cutting short the most acute fevers with a few doses of medicine, have not exercised as disasterous an effect on medical sciences, in the confidence of patients, iu their advisers. Uuconsciously and involuntarily medical practioners have been sometimes tempted by the urgent desires of their friends, for speedy reh«f to the sufferers and for his immediate deliverance from danger, to spend their energy upon the weakest and to neglect 31 to stronger part of the defense against disease. It can never be too often repeated, that by the most difficult aud scientific portion of the medical man's task, iu the treatment of yellow fever, is the direction of hygienic measures, and above all, the apportionment of the medicines, and the exact manner in which that medicine shall be given, aud that these are the means by the right practice, of which the physician saves his patieuts, in ninety out of a huudred cases, which recover from dangerous attacks of malignant epidemic yellow fever. REGULATION OF CONVALESCENCE. When convalescence has begun, the patient should be close- ly watched, lest by some impropriety he be suddenly cut off. Even after having passed near unto death's door, and when his march toward health, with all its renewed charms and pros- pects, the most important part of the management of conva- lescents refers to diet and exercise, etc. The necessity of caution in the quantity and quality of food at this time is even greater than during the progress of the fever, and cannot be too strongly urged upon the attention of the attendants. From simple liquids which were all that were required to satisfy the desires of the patieut during his period of febrile excitement, and to more stimulating and solid nourish- ment, the transition should be gradual. From inattention to this point in the management, a speedy and happy convalescence has often gravely interrupted, aud many instances are on record of death having resulted. No error is greater and more common among patients and their friends than supposing that debility is always to be removed by nourishing and stimulating food, wine or other stimulating beverages. I have seen convalescents suffer most severely from a single improper meal. The first change of diet should be to another article of the same kind of food as was allowed during the progress of the dis- ease. For example,from simple arrow root mucilage to arrowroot and milk or to some other of the farinaceous compounds. From this advance may be made to corn or ricemeal mush, milk and rice, well-boiled, aud served up with milk aud sugar, nutmeg or other spice, rice puddiug and custard. If the patient de- sire it, he may partake of some of the fruits, such as oranges, strawberries aud grapes, freed of their skin aud seed. Iu the allowance of animal food, it is best to begin with broths of chicken, squirrel, beef or mutton, ou account of its less stimu- lanting nourishment and easy digestion. When wine is used, attention should be paid to the kind and quautity. Sherry and claret are, perhaps, preferable. In fixing the quality to be allowed, the age, the degree of debility and previous habits of the patient, should be taken iuto account. It should be remem- bered that young persons and females are more easily excited by stimulants of this class than older persons; that youug per- 32 sons, as a general rule, convalesce more rapidly than the »ged; therefore, thev require leas stimulant in proportion. If the patient, when'in health, has been in the habit of taking wine or other alcoholic stimulants, he will reqnre wine in more liberal quantities than if he had been strictly temperate, both during the fever and in convalescence. As health becomes confirmed, it should be gradually withdrawn. When convalescence becomes tedious and profuse and ex- hausting sweats occur at night, much benefit will accrue from the administration of the aromatic sulphuric acid. Conva- lescence appears to be sometimes very much retarded by a debility of the stomach, which disable the alimeutary canal. From its appointed function, a species of hectic excitement is sustained for a long time. The pulse remains frequent, some- thing like a febrile paroxysm occurs every afternoon and the patient sweats copiously at night. Under these circumstances 1 have found nothing so effectual as the following formula : R Iodine, ~j Potassa Iodide, 3ij Syrup auranti corti, za\\ M.—Ten drops in two tablespoonfuls cold water every three hours. With regard to exercise, not less care is required than con- cerning the allowance of food. Convalescents soon grow tired of their beds, and not a few. if unopposed, will overtask their feeble strength by long sittings out of bed. Errors of this sort have not unfrequently been followed by very bad consequences. Iu quitting his bed the patient should do so gradually ; even should the observance of this advice be unnecessarily strict, no danger can result; whereas, if disregarded, dangerous if not fatal consequences may be incurred. Especial care is to be observed in the return to out-door ex- ercise. The patient may have acquired sufficient strength to allow of his being out of the bed the greater part of the day, but he should not on this account thrust himself out of doors. Injury has often resulted from venturing out too early during the hot weather of summer and fall. That many persons who have struggled through a most dangerous fever, have, from imprudent exposure to heat, been seized with iutense inflam- mation in some organ which rapidly destroyed life. The Editor of the London Lancet, Feb., 1872, remarks, as beariug upon the important question of restraining extreme heat of the body in fevers: ''We must remember that, whereas, the nitrogen containing tissues are hardly consumed at all iu circumstances of health. The febrile state involved a large destruction of the most iiupoitant organs of the body, partly from the effect of the excessive febrile heat on the vitality of the blood. Exces- sive heat does not meau pleuty of strength, but exactly the op- posite ; it is an absolute proof that the reserve forces of the 33 body are exceedingly low, and are being constantly and rapidly reduced." During convalescence every source of mental exertion should be strictly avoided. The mind should be engaged without being oppressed. Much advantage may be afforded the patient by a proper selection of visitors. For, above all things, the presence of idle gossipersshould be avoided. These miseries, with which the State of Louisiana is infested, are usually very kind indeed, that they almost invariably leave an infallible pre- scription of medicine or diet at each successive visit, which benefitted Mr. and Mr, so and so, who was for all the world in a similar condition, aud it was used by Dr. somebody and highly recommended by the Reverend Mr. Sool. The imprudent use of cold water when a person is over-heated almost invariably produces spasms of the stomach, wheu specially bathed in sweat after fever; this dangerous and fatal practice, if it even does not produce immediate death, almost invariably lays the foundation of lingering and destructive fevers which are extremely difficult of cure. That eminent and distinguished physician, Benjamin Rush, describes the causes of fatality in these cases, in the following manner: '< When large quantities of cold water are taken into the stomach, under circumstances of fever or over-heated system, the per- son in a few minutes afterwards loses his sight and everything appears dark about him, the breathing soou becomes very difficult and a rattling noise is heard in the lungs and throat, the feet and hands become cold, and the pulse cannot be felt, and generally death is the consequeuce, unless speedy relief can be obtained." Iced toddy, wheu taken under the same circum- stances of being overheated, has ofteu been known to produce the same fatal effects, and I have known many instances within the city of New Orleans aud in my parish, iu which ladies in full health have been brought to the brink of eternity in a few minutes from eating iced cream when over-heated by dancing. The truth is that very cold drink, even when the body of a patient moderately cool, iu fever, sometimes iu peculiar consti- tutions are productive of dangerous consequences; therefore, cold water should not be used as a beverage in fevers ; boiled water and cold quenches thirst more permanently, and is not liable to produce vomiting, and does not lower the temperature of the constitution in fever as it does not in air, after being boiled. There are no countries within the regions of endemic and sporadic fevers, which therefore are subject to intermit during periods of greater or less extent. In the city of Vera Cruz, the yellow fever, now so prevalent, did not prevail during the space of nineteen years. The first distinct account of its appearance given at Barbadoes in the year of 1607, as it appeared in that island in lf>08, it occurred at Boston and Quebec, and the next year appeared at Richmond, Va., 34 and iu Brazil the jellow fever appeared in the years 1687 and 1693, then the disease did not prevail for one hundred and fifty-nine years during that whole length of time. After some years it declines from its producting real effects, and recurring at interval periods of time and thus, on certain series of years, with seventy as all epidemic fevers do. Consequently yellow fever like all other epidemics, which have been already ob- served and reported from real statistics in various parta of the world, has its period of activitity and lay up at intervals in harmony for a space of time, between each event. New Orleans was free from it during thirteen years from 1841 to 1853, except an eudemic of ship fever or typhus, which oocurred in the year 1847, amongst emigrant passengers to the port of New Orleans. All epidemics of yellow fever are like all other, owing to no aclimation and being an inurement of benefit, once having it, and is an advantage for those persons who are to be insured, whether native or foreigner against its prevalence, although having been acclimated at that season however, which should be considered an acclimating fever, which is to moat persons a condition of being secured from the further auxiety of the future. Its epidemic aspect was of the earlier and more frequent occurrence in northern cities than iu the southern cities. During this century and its epidemic wave, was never known south of the equator; on its first appearauoe in the last century, within the southern regions of countries in North America, in the single year 1872, more than two hundred thousand died in cities of Montreal, New York and Philadelphia, in America, and Paris, France, and other cities iu Europe, one hundred aud thirty thousaud were victims of an essential disease typhoid fever. Meanwhile at times, the phenomena of fever, which seemed to prove its nature to be highly malignant in severity, in a great many parts of the world, aud we have a strikiug illustration of the elements of both, the typhoid and yellow fever, consequently, through the efforts of the medical profession and judgment are of the opiuion that the former epidemics of yellow fever have greatly ameliorated its severity. Therefore, we should look forward to a great change aud per^ haps exemption from an epidemic visitation in our loved land for many years. There should be no panic about yellow fever, particularly in the State of Louisiana. Let the authorities do their full duty in sanitary measures of local improvement and renovation, not to hide themselves out of view through the delusive scheme of quarantine bubbles, who lie concealed in the very focus of its existence aud production, and are more liable to its efficient effects on their system. Let them give to our parishes and our metropolis, the city of New Orleans, its pristine clean- liness, and yellow fever may reach and sweep across the equator without a case occurring in our State. Baltimore and Wh«I«- 35 ington City have had such an immunity of visitation of yellow fever more than once, and in our worst eruption the mortality has not been very great. Apprehensions, moreover, aggravate the danger, while, if it appears again, those who can leave, as well as those who cannot, will undoubtedly be most safe in the open country, for those whose duties keep them in the metropo- lis of New Orleans. Courage and equanimity are not only be- coming but expedient. In referring to the production of yellow fever in every instance to a material agency, we mean, also, to deny its propa- gation by contagion. Many are acquainted with the foregoing facts. Dr. L. Lamar, a physician who practiced in the city of New Orleans, in 1837, made many trials by experiments, to produce yellow fever by direct contact, who had inhaled his patient's breath and inoculated himself with the blood of yellow fever patients and tasted their dejections without receiving the yellow fever, and Dr. L. Lamar, in Havana, who in that city in 1839 and 1841, during the yellow fever epidemics of those years lay all night in the beds and in the clothes of many of his pa- tients, but was not affected or attacked by it. I have made many other experiments, as Dr. Lamar, without suffering any injury or sickness whatever. There is but slight exaggeration in proverbial assertion that pestilence kills thousands, but fear tens of thousands. Above all, tell every man in Louisiana, in the hope thac no mistaken terror of contagion will ever lead to the extreme barbarity of deserting of the sick, whether rich or poor, or neglect of the dead. Yellow fever is not after all a very serious disease to treat. To many experienced physicians it is one of the easiest to cure and is one of the most reliable to prevent death, when attacked from other diseases afterwards, and from any other foreruuuing maladies of the human races in the world, and who has had it once or having passed through it, which has been ascertained by established truth and fact of proofs. The subject being entirely practical, I have confined myself aa much as possible to a detail of facts. If at any time I have been led into digression, it has been solely with tjje object of elucidating some point of evincing importance, Lafourche Parish, La., October, 1878. ZJ *