ry)yvuAu^Ji (ff. RJ INTRODUCTORY LECTURE BEFORE THE MEDICAL CLASS lUtttucfeg 3tln\ of §|Aine, THE TRUTH OF MEDICINE AS EVINCED BY ITS ORIGIN, PROGRESS AND PRESENT CONDITION. 2^ BY N. B. MARSHALL, PROFESSOR OF MATERIA MEDICA AND THERAPEUTICS. ..t-P-U LOUISVILLE: COURIER STEAM BOOK AND JOB OFFICE, GREEN STREET, SOtJTH SIDE. 1860. INTRODUCTORY LECTURE. Having to appear this evening before an audience composed of those who are, as well as those who are not, engaged in the prosecution of the medical science, it would be equally inappropriate in me to dwell upon a subject strictly professional, and which would therefore necessitate the employ- ment of technical terms not generally understood, or on one bearing no di- rect relation to medicine, and I therefore propose to consider briefly the ev- idence of the truth of our science, as afforded by its origin, progress and present condition. When we contemplate any of those things on the earth which men call and consider great, and are enabled to follow them back through all the dif- ferent phases of their growth to their origin, we are, in many instances, as- tonished at the siuallness of their beginning; nor can the most far-seeing form any adequate idea of the immensity of the superstructures which may arise on apparently the slightest foundations, or estimate the extent of the influences they may exert on man and the world. The most powerful king- doms of the earth have passed through an infancy of weakness and depend- ence, which afforded scarcely the least foreshadowing of their future great- ness and importance. Remus, in derision, stepped over the walls of a city destined to be the mistress of the world, while a region remote from thence, and, in the progress of her arms, fated to become merely one of her con- quered provinces, has now attained the magnitude of one of the first pow- ers of the earth ; while, stranger still, a little island, yet more remote, and then altogether unheard of, now boasts herself, and with truth, the centre of an empire on whose bounds the sun does never set. Not less true is this in regard to the origin of the arts and sciences, and the most valuable in- ventions and discoveries, which have lent their aid to the progress of man. Galileo, after hearing that the Prince Maurice had been presented by a German with an optical instrument which made distant objects appear near, employed himself in ascertaining what that instrument was, and his first efforts produced only a leaden tube with a plano-convex spectacle glass in the distant and a plano-concave one in the near extremity. Who could have imagined that from such a beginning would grow the telescope of the present day, with magnifying powers so immense, that the astronomer is en- abled to peer millions of miles into the realms of illimitable space and bring within the sphere of his observation stars and planets, whose distance from the earth is so great as to be, although easily expressed by figures, yet scarcely appreciated by the human mind ? But if founded on the eternal principles of truth, although we may not be able to predict the extent and magnitude of the superstructure, we yet may be assured that it will stand the test of ages ; and if, in addition to this, it have for its object the good and improvement of mankind, and, still more, if the inevitable tendency be to accomplish this object, we may be pretty sure, nay, almost certain, that the dimensions will attain magnificent proportions. Everything dependent on man as originator, inventor, or discoverer, is progressive, often accumu- lating in its progress much of error and wrong, before attaining its full measure of perfection. This may surely be predicated of all things not emanating directly from the Supreme Being, whose power alone is sufficient at once for origination and perfection. Thus may we be prepared, in glan- cing at the rise, progress, and present condition of medicine, to find at its commencement insignificance, in its progress error, and in its present con- 4 dition much of imperfection, without regarding these as evidences of falsity in the principles of our science; but, on the contrary, its existence at all lit the present dav, must be admitted as a high indication'of its truth. Now we are'not to confound the principles of medicine with the different and often conflicting theories which have been entertained and abandoned at various periods of its history. The principles of medicine are those which have been deduced from facts that have been the subjects of obser- vation and investigation for centuries upon centuries, and therefore have the authority and sanction of vast and extended experience. By the side of such experience, how contemptibly insignificant appears the boasted ex- perience of the different isms and pathies which from time to time have reared their ephemeral heads against the truth of regular practice? Medicine, or the administration of remedies for disease, arose as the nat- ural consequence of the fall of man. Driven from the garden of Eden, he was compelled to till the ground for the sustenance of his body, and he soon found himself subject to aches and pains, against which it became as neces- sary to provide as against the pangs of hunger. For almost all of the suffer- ings and afflictions resulting from the fall, an all-wise and merciful God has seen fit to give us a remedy, and reason and analogy alone might have taught us, without the positive evidence afforded by what medicine has done and is still accomplishing, that with the bane disease there was also provided an an- tidote. Whether the first efforts towards the mitigation of the ravages of disease by the administration of medicines arose through direct information from the Supreme Being, or were the result of faith in His merciful provision for such sufferings, we cannot tell. To the former idea mythology, the crea- tion of man's unaided reason and fancy points, attributing the primal ideas of physic to direct revelation from the gods, touched with pity at beholding the unchecked ravages of disease, let loose upon the earth through the ire of some of their own number. However this may be, we may well suppose that the first steps in this direction were simple and few; but from this begin- ning, small as it was, has resulted a science, which is acknowledged wherever civilization has extended, while even among the most rude and savage of the earth we find traces of the efforts of man in this direction. Now this in itself is strong presumptive evidence of the truth of regular medicine, for it is hardly probable, indeed it is utterly impossible to suppose, that anything de- void of truth (although we may readily admit that such a thing might find birth and even take powerful hold upon the feelings and opinions of men in rude states of society) should grow and increase through age after age, with- standing from time to time the most violent assaults of the learned and un- learned upon it, and now, in spite of time and attack in the nineteenth cen- tury, should, under the most scrutinizing investigation, stand forth as an ad- mitted science, and claim among its votaries and supporters many of the no- blest and brightest intellects of the world. Nor is it necessary for the weight of this evidence that the ideas and opinions entertained throughout this vast period of time should have always been identical and the same ; for that would imply the perfection of a science at its commencement, full growth at the first dawn of infancy. It would be requiring what has not been true with regard to any discovery or science, and what is, moreover, totally at variance with a state of progress and improvement, the natural, necessary, and perpetual con- dition of man. The original idea was unquestionably to administer medicine for the relief of suffering, the cure of disease. Here evidently was a belief in the existence of two forces or powers antagonistic to each other, disease on one hand, remedies on the other; and it was the direct object and aim of the first, and indeed of all subsequent research and investigation, to discover such powers or influences in medicines and other remedial means as should overcome and eradicate the causes of disease, as well as disease itself. This is the idea which has been acted upon through all ages, from the first concep- tion of it to the present time, which gave rise to, and is at the foundation of, regular medicine, and which I say could hardly, could not possibly have main- 5 tained its hold upon the opinions of men, and now convince enlightened rea- son, if it were destitute of truth. If the treatment of disease were a matter with which mankind at large were but little if at all concerned, there would be some better ground for sup- posing that a stupendous fraud yet undiscovered might have been from time immemorial imposed upon man's credulity. But it is, on the contrary, a sub- ject in which all, the highest and the lowest, the most learned and the most ignorant, alike are intimately and anxiously interested, and as the issue is life or death for all, the investigators themselves must at all times, equally with the community, have been anxious to ascertain as nearly as possible what was truth in regard to this subject. The evidences of the existence of a Supreme Being and of the truth of re- ligion are many and varied, and among these the fact that in all times and among all nations there has prevailed a belief in a being or beings superior to man, and to whom worship was accorded, however wild and far from the truth many of the ideas connected with the subject may have been, is considered to carry much weight, and with great propriety is urged as an important link in the argument. Now we have this evidence to its fullest extent, as to the truth of some system of practice, for as far back as we can find any record of a nation's history, so early do we find traces of medicine. We have, for in- stance, the most certain evidence that we can possibly have in regard to any transactions of so remote a date, that nearly if not quite two thousand years before the Christian era, remedies were applied for the relief of disease, or, in other words, that a practice of medicine existed in Egypt. As among all other nations in their primitive estate, even down to the present day, so among the ancient Egyptians, the priests were the first rude practitioners, from whose hands this business or profession gradually passed to regular physicians. Somewhat later we have record of some of the medicines they employed, and of these one at least is used at the present day, namely, squill or sea onion, a bulbous plant, which was even worshipped on account of its nu- merous virtues, and administered for the cure of a variety of diseases. The beginning of medicine, at least the first that we have any knowledge of among this people, destined in after years to take the lead of the world in this as well as the other sciences and arts, was slight and insignificant in- deed as compared with the enlarged knowledge and experience of the pres- ent day, but there existed even then and there the germ of that great truth, the basis and foundation of our science of physic, namely, that there ex- ists in medicines a power antagonistic to, and capable of counteracting and overcoming, the morbid influences and effects of disease. They knew and thought little no doubt of the modus operandi of medicines, being concerned with that which was the chief if not the only matter of real interest to them, the action itself of medicines, and the useful application of that action. All their investigations were directed toward this point, and their system of practice was derived from observation, experience being then as now the only proper test of theory. This same kind of testimony we have afforded by the history of all nations of whom we can learn anything with precision. Probably the most ancient reliable information in regard to the practice of medicine after that obtained from the history of the Egyptians, is derived from the tribes which afterward formed the nation of the Greeks, among whom, at a very earbjp period, medicine attained a position of com- parative importance. Among this people we have traces, although not en- tirely authentic and accurate, of medicine long prior to the Trojan wax, and after that event, up to the Christian era, we have tolerably accurate and reliable data to sustain the belief that the art was practiced with some de- gree of success. At a later date, as we shall presently see, yet when the nations of the earth had conceived only the rudiments of other arts and sciences which have come down to us along with mediciue, this latter sci- ence had attained to a condition of system and importance incompatible with absolute falsehood, although, it must be admitted, something of una- 6 voidable error was mixed up with the truth. The history of the Jews, de- rived from writers sacred and profane, may also be appealed to as affording conclusive evidence of the existence of, and a thorough belief in, medicine All knowledge of this subject, among them, as among all other nations, was at first confined to the priests, and we therefore find Moses in the place of high priest, issuing laws and directions in regard to leprosy, and other uncleanness or disease. The views among the Jews at this period were no doubt similar to those entertained by the Egyptians, a» all knowl- edge on this subject, exclusive of that afforded by direct revelation after the departure from Egypt, was no doubt that which had been obtained in the land of Egypt, as we can hardly suppose that the teachings of the pa- triarchs in this matter, if they taught at all, could have survived, as dis- tinct notions, the long and oppressive Egyptian bondage. At the death of the patriardi Jacob, his son Joseph employed Egyptians, as we find in sa- cred writ that "Joseph commanded his servants, the physicians, to embalm 1 his father, and the physicians embalmed Israel." [Genesis, c. 1, ver: 2.] These servants were unquestionably Egyptians, who would not have been employed to perform this last office for the deceased patriarch, if among the Hebrews there had existed knowledge sufficient for this purpose. But later in the history of this latter people, as will be presently referred to, medi- cine, as among the Egyptians and Greeks, instead of dying out, as fancies and traditions unfounded in truth ordinarily do, had steadily advanced, and at a period when they were better able to discriminate between impos- ture and truth, commanded almost universal belief. An examination of the earliest records of the Hindoos, Chinese, Ara- bians, and at a later day the Indians of North and South America, afford the same testimony; among all we find a belief in medicine, and a system of practice. Is it not beyond all reason to suppose that this idea in regard to the truth of medicine, found to exist as the spontaneous conviction of the human mind, should have thus universally prevailed, if there were not truth connected with it somewhere? Had it passed away, as superstitions and fallacies ordinarily do, with the advance of civilization, this question could not be before US to-night; but here it is—medicine is still practiced and believed in all over the world, and that too by the wisest of our race, the beat informed and the most intellectual of mankind being fehe most decided adherents and supporters of regular medicine. I do not yet advert to the evidence afforded by what our profession is doing, and has already accom- plished, for the good and happiness of the human race, that being an argu- ment of no little weight as will be seen; but I have simply considered and applied one of Uhe forms of evidence which is urged to prove the existence of a Supreme Being and the truth of religion. I pass on to the consideration of the condition of medicine at a later pe- riod in the world's history, when civilization had extended its beneficent influences, when states were established on the basis of right, law, and or- der, when the records which have come down to us are fuller and more reli- able, and when medicine had attained a position and system worthy of a science. The limits of a lecture permit me to refer only to facts and cir- cumstances establishing the truth of medicine, without noticing the differ- ent attacks which have been met and defeated, and the heresies which at variouB periods in its history have assailed it, which are yet attempting its overthrow, and which will no doubt continue to afflict mankind, so long as there shall be found those who are ready to use charlatanry and imposture to gratify insatiate lust for gold, and there exists in the human mind such passion for the marvellous and absurd, as must ever render man an eaBy victim to impudence and assurance. But this much at least may be re- marked, that none of the different forms of quackery which either hereto- fore have attracted, or are at present gulling the people, possess the evi- dence of truth which I am now considering, and are therefore declared, so far as this evidence goes, to be utterly false. 7 It has been frequently remarked, and is unquestionably true, that the arts and sciences, though cradled in the east, have yet attained their mag- nitude and power in the west. The Egyptians, Phenicians and Chaldeans had been, before the Trojan war, at the head of existing civilization, sur- passing all other nations, except the Jews, in the extent and value of their knowledge and discoveries. Medicine was much further advanced among these nations than among the Greeks, who subsequently took the lead and transmitted even to the present age a great deal that is valuable not only in this but other arts and sciences. Among the Jews arose one whose name is almost synonymous with wisdom, and who attained an amount of knowl- edge in regard to medicine, as well as other things, far exceeding the men of his time. Solomon, we are told, "spake of trees, from the cedar tree that is Lebanon even unto the hyssop that springeth out of the wall; he spake also of beasts and of fowl, and of creeping things and of fishes."* That he was acquainted with the medicinal Character of many of these trees and herbs, we cannot doubt, and indeed the most eminent historian of antiquity remarks that "the sagacity and wisdom which God had bestowed on Solomon was so great that he exceeded the ancients, insomuch that he was no way inferior to the Egyptians, who are said to have been beyond all men in understanding," and that " he spake a parable upon every sort of tree, from the hyssop to the cedar; and in like manner also about beasts, about all sorts of living creatures, whether upon the earth, or in the seas, or in the air; for he was not unacquainted with any of their natures, nor omitted inquiries about them, but described them all like a philosopher, and demonstrated his exquisite knowledge, of their several properties;''! and he further adds that he availed himself of this knowledge to compound remedies, which were extremely useful for various purposes. Thus we see that at a time when the Jews had advanced in the knowledge of mathe- matics, architecture and decoration, sufficiently to build a temple unsur- passed in magnificence and taste by anything that the present age can ex- hibit, medicine having outlived the superstitions incidental to the infancy of a people, was acknowledged and practiced by the wisest prince that ever filled a throne. After this period, when the kingdom of Priam had been crushed, we must look to the Greeks, to ascertain the condition of medi- cine, and through them we are enabled to trace its progress with a great deal of certainty. For a period of about three hundred years after the fall of Troy, all knowledge of medicine; so far as it may then be considered a science, was confined to the priests of Esculapius, and the practice of it was exclusively in their hands. Dark as this period was for our science, it was unquestionably the best arrangement under existing circumstances, and the popular mind, yet sadly under the thraldom of superstition, was in the fittest state to tolerate the impositions of those priests, shrouded in mystery and clothed with the sanctity of religion. Temples were built in various places, but always the most salubrious localities were selected, where the sick might be surrounded by every circumstance most conducive to health. To these temples, sacred to the God of Medicine, flocked the people who were suffering with disease, invariably with offerings of some kind, and not unfrequently of great value, without which the god might not be consulted with any expectation of success. Admitted within the precincts of these sacred dispensaries, the sick found themselves surrounded by scenes of diversion, while carefully prescribed regimen, pure air, the strictest attention to cleanliness, and especially the strong hope of relief, and a high degree of faith, kept alive by the remarkable instances of cure which were constantly sounded in their ears, produced that happy influ- ence on the mind and feelings which might naturally be expected, very efficiently to co-operate with the simple medicines which were adminis- tered. But the cure of diseases was by no means trusted to these assisting *lst Kings, chap. 4, ver. 38. tJ°sePhu8> Antiq. of the Jews, lib. S, chap. 2. 8 circumstances alone, for the Asclepiadoe employed vomits, purges, frictions with medicated substances, sea-bathing, and, according to very good au- thority, even blood letting also. As the constitutions of the patients were generally more vigorous than after the introduction of greater refinement and luxury, and the diseases therefore simpler and more amenable to such remedial means as were employed, the practice of the temples was far more successful then than it would be at the present day. In the vicinity of some of these temples were found serpents, which, being easily tamed, and their bites innocuous, were employed by the priests in their miraculous manifestations, sometimes to personate the god himself, sometimes merely to impress the minds of their patients. These serpents, accustomed to the presence of man, glided naturally about amidst the wondering crowd, their movements being supposed to indicate in some way or other the inclination of the god, or, during the silence of the night, while the patients on their couches distributed throughout the chambers, had merely light sufficient to distinguish vaguely what was enacted around them, approached the altars loaded with offerings of edibles and other more valuable gifts, and devour- ing the former, removed the latter to the more secret recesses of the temple. But the remarkable gastronomic feats sometimes displayed on these occa- sions, afford good reason to suppose that these apparitions were frequently machines, resembling serpents, and containing within them one or more men, and not, as the faithful believed, real snakes. We may be inclined to wonder at the credulity of any age that could tolerate such absurdities, but we may hardly boast of the intelligence and enlightenment of our own, when now, late in the nineteenth century, hundreds, yes, and thousands, repose implicit faith in mesmerism, and spiritualism, andinfinitessimalism, and there are found in this city those claiming the first position in society and refinement, consulting oracles whose prescriptions are the blood of a live weazel for deafness, split cats and chickens for erysipelas, and whose diagnosis is based upon the description of a patient's complexion and physical contour, or even the examination of a lock of hair transmitted through a letter or otherwise.* But even through the period referred to medicine did not retrograde, nor yet stand still. The Asclepiadoe were far above the generality of their time, in education and intelligence, and could not avoid obtaining some medical information and acumen from the experience afforded by the vast number of patients who consulted them; and we find, therefore, that when public opinion forced a change in the system of secresy, which was rigidly ob- served in regard to the mysteries pertaining to their religious worship and practice of physic, that the science had"' made considerable progress. In the then existing state of the world and society, the confinement of the practice of medicine to the temples was most propitious for the science, and greater progress was made there, and less of absurdity and error accumu- lated upon the fruth, than if it had been open and common to the public. But the time arrived when philosophy began to dawn upon the benighted world—when there were intellects capable of appreciating the lights of truth and science, and when the popular mind, too, was beginning to be better prepared for the reception of instruction. Chance rules in nothing, and when the fitting time had fully come, men and circumstances were found ready for the work and developments appropriate to the age. A Pythagoras was born, and gifted with a mind capable of grappling, in a great measure successfully, with the highest questions of the day, he was instrumental, though not intentionally, in breaking the bans of secresy which had hitherto veiled the practices of the temples. His studies and teachings were of n varied character, his life pure and even austere, and his disciples, following his directions and imitating his example, acquired an immense influence among the people, through their communities established in various locations throughout greater and lesser Greece.t Before being ^'Theae references are entirely true. fKenouard. 9 admitted fully to the companionship of this great master, these disciples were obliged to prove their constancy and devotion by a severe and trying noviciate of five or six years' duration, during which period tl\ey were re- quired to abstain almost entirely from conversation with any one not con- nected with their community. When admitted to full discipleship, they were still compelled to lead a quiet and even secluded life; and thus, re- markable for their abstinence and avoidance of the dissolute manners of the day, as well as the real superiority of their knowledge, they acquired an influence and exercised a wholesome restraint over the morals of the people. But their success was itself the cause of their downfall. Em- boldened by the deference and obedience accorded their wisdom and opin- ions, some of them, contrary to the express precepts and example of their illustrious teacher, began to entangle themselves with the political intrigues of the day, and thus lost the esteem and confidence of all parties. Op- posed by the politicians, because of their interfering with and often thwarting their projects of aggrandizement, hated, as well as dreaded by the priests, because of their superiority to the superstitious prejudices of the multitude, and rejection of the tyrannical rule of the priesthood, they found friends on no side, and soon losing the admiration and support of a fickle populace, urged on by their more powerful and sagacious foes, they encountered a storm of hatred and persecution, which only ended with their utter dispersion But their misfortunes and downfall, by a wise and deter- mined ordering of events, proved only a stepping stone for the advance- ment of the arts and sciences, and more especially of medicine. Scattered in every direction, and no longer bound together by the ties which once had held them, of which strict secresy was not the least influential, the Pytha- goreans revealed their knowledge^and doctrines and many of them became distinguished followers of the practice of medicine. To them is due the introduction of the plan of visiting patients at their own places of abode, instead of the original custom of the Asclepiadoe, of prescribing for them only in the temples. That we may form some idea of the medical acumen of the Pythagoreans, and discard utterly the erroneous impression that their practice was simply a system of jugglery and old wives' tales, as has been affirmed, I may mention instances of whole communities benefitted and thousands of lives saved by the medical acumen of one man. Agri- gentum was visited annually by a pestilential fever—probably of a malig- nant bilious type—which swept off multitudes at each return. Empedocles observed that the visits of this scourge were simultaneous with the preva- lence of a southeasterly wind—the sirocco—and, concluding that its breath was loaded with the causes of this plague, advised the construction of a high wall across a narrow gorge, which was its only channel of approach to his native city. His advice was followed, and that annual scourge ceased to be a terror to the inhabitants of Agrigentum. Selinus was traversed by a stream whose waters were sluggish, and therefore exceedingly liable to become stagnant. Disease was the conse- quence, which, with the system and regularity of a destroying angel, deci- mated its inhabitants. Empedocles, by having turned into the course of this stream two neighboring creeks, imparted rapid motion to its current, prevented stagnation, and thus the formation of unwholesome vapors, and relieved an apparently doomed community from a hitherto dreaded and irresistible enemy» Such acts are more worthy of crowning bays than victories in a thousand fights; such are some of the monuments left behind them by the founders of our profession, and such the emana- tions from a science yet in its almost earliest infancy, which is still on its march of mercy and mitigation of the necessary sufferings of man- kind, and which, from the lasting necessities of humanity, must con- tinue its march of improvement, continually approximating a perfection which is never absolutely attained nor attainable by man. In view of such records as these on the pages of profane history, we may well be 10 prepared to see a short time afterward the ample testimony furnished by one of the books of the Bible to the great value of medicine, the truth of the art, and the great good and benefits it is capable, under the blessing of Providence, of affording our race. What can be more full, more direct, and I may add, without, I hope, being charged with overweening pride in my calling, more appropriate than these words? 1. "Honor a physician with the honor due unto him for the uses which ye may have of him, for the Lord hath created him. 2. For of the Most High coiueth healing, and he shall receive honor of the king. 3. The skill of the physician shall lift up his head; and in the sight of great men he shall be in admiration. 4 The Lord hath created medicines out of the earth; and he that is wise will not abhor them. 5. Was not the water made sweet with wood, that the virtue thereof might be known? 0. And he hath given men skill, that he might be honored in his marvellous works. 7. With such doth he heal [men] and taketh away their pains. 8. Of such doth the apothecary make a confection; and of his works there is no end; and from him is peace over all the earth. 9. My son, in thy sickness be not negligent, but pray unto the Lord, and he will make thee whole 10. Leave off from sin, and order thine hands aright, and cleanse thy heart from all wickedness. 11. Give a sweet savour, and a memorial of fine flour; and make a fat offering, as not being. 12. Then give place to the physician, for the Lord hath created him; let him not go from thee, for theu hast need of him. 13. There is a time when in their hands there is good success. 14. For they shall also pray unto the Lord, that he would prosper that which they give for ease and remedy to prolong lite."* Now this, as well as all that has been said, can only apply to medi- cine at that day, and from which regular medicine is descended. All that was believed then is not believed now, but many of the principles then laid down are not disputed to the present day, while we have been steadily advancing, adding improvement to improvement, and relinquish- ing error, according as the sagacity, research and observation of inves- tigators could eliminate more and more of truth. If, then, these obser- vations apply to medicine at that day—and who can deny it?—they cannot apply to any of the fancies with which crazed or designing brains have attempted to overthrow what is here so emphatically ad- mitted, and by such silence in regard to them, as much as they could by direct abnegation, ignore them all. But it will surely be claimed that these innovations are improvements on the regular system, and, being derived from it, the above testimony does apply to them. It will apply certainly as much to one as to another of them, to Thompsoniau- isiii, Homeopathy and all that ilk. Are they all right? All claim to be so, and equally condemn each other and regular medicine. There is and can be no common ground between regular medicine and any of these absurdities; they are at utter variance and antagonism. There can- not be two truths asserting entirely opposite doctrines; either they, or some one of them is true, and medicine false, or "vice versa." They are opposed to what was then admitted to be true; they did not exist, nor the semblance of any one of them at that day, and as the testimony above adduced can only refer to what then existed, it cannot apply to any of the forms of modern quackery, but must point to regular medi- cine, and to that alone. They apply as much, and no more, to all of "Ecclesiasticus, chap, xxxviii, ver. 1 to 14 inclusive. 11 these different systems, as do the teachings of our Saviour in regard to his religion and his church, to the additions and mummeries of the dark ages, which, while usurping—as these have done in regard to medicine— the name and place of true religion, almost blotted it from the earth. Yet there were found believers enough for these as for every species of quackery and jugglery that was ever started from the origin of medi- cine to the days of Hahneman, or Thompson, or the Black Doctor of Paris. The march of medicine has been ever onward like the course of time, each succeeding generation taking up the work where their predecessors left it, to add their mite to the store, to be handed down to their suc- cessors. While generally so, this has not been universally and absolutely the case, for there have been several periods when adverse circumstances for a while impeded and stopped its march, if they did not actually force a retrograde movement. During a considerable time after the dis- persion of the l'ythagorians its advance was rapid. These, scattered over the civilized world, and forced, for self-preservation, to break the silence which, by their vows and teachings, had been imposed upon them, at last drove the Asclepiadoe themselves, through jealousy and dread of the influence which the public discussions and teachings and practice of the Pythngorians were gaining for them among the people, to discard their time-honored Egypto-Indian plan of secresy, and bring to light the principles and rules of their practice. Thus encouraged, discussions everywhere increased, and soon evolving the idea of sys- tematically teaching what could as yet only be obtained by fragmentary gleanings, they called into existence, at various places, schools of con- siderable celebrity. Among the most renowned of these were those of Cos and Cuidus. The former was adorned by that philosopher and phy- sician whose fame can never die, whose name must occupy one of the proudest places in history, while any history of the past remains, and who indeed gave a name to medicine, since from his day it ceased to be called the art of Esculapius and became known as the science of Hip- pocrates. This was an age of giants, the names of Plato, Socrates, Cimon, Pericles, and, a little later, Aristotle, and others of like stamp, all flourishing about the same time, form a galaxy uneclipsed in any age or state, and throw an imperishable and unfading halo about that period. It was an age of philosophy, when all questions worthy of the consideration of such intellects, received a most searching investigation; and it was an age of honesty and integrity, when truth, rather than temporary eclat and popularity, was the aim and object of their efforts. Surely a most unpropitious age it was for falsehood and error and a proportionably happy and genial one for all that was good and true and whatever was really calculated to benefit, the human race. How did medicine stand the test of such a time? While other falsely called arts and sciences and time-honored opinions paled before the bright light of truth and philosophy, then blazing upon them, medicine came forth as gold purified by the fire, and though as yet only the foundations for the future edifice were laid, and the plans for the huge structure to be raised, mapped out, yet through this period it advanced with unprece- dented rapidity, while rubbish was removed, the mystic veil stripped off, and a condition attained for solid and permanent improvement. The questions which agitated the public mind, and engaged the atten- tion of the learned, fully attest the minute observation and scrutinizing investigation of those ancient philosophers and physicians. To this pe- riod succeeded the age of the Macedonian conqueror. Engaged in the prosecution of such invasions and victories as the world had never be- fore seen, Alexander yet found means and time to make some contribu- tions to science, through his distinguished preceptor. But the lieuten- ants of this great captain went further still, and after the division among themselves of their master's dominions, two of them, one at Per- 12 gamos, the other at Alexandria in Egypt, set about the collection of those libraries, the wonder of every age, the glory of their own. These libraries exercised a great influence over the advancement of civiliza- tion by stimulating attention to the arts and sciences, among which medicine received no little share. Dissections soon became not only le- galized, but were liberally encouraged; and thus a knowledge of anat- omy was obtained, the want of which had hitherto been a serious im- pediment to the progress of the profession. Nor was the prosecution of these investigations confined to the savans alone, but princes of the royal blood were among the number of those who, with scalpel in hand, pushed forward their explorations into the fields of physiology and anat- omy. The City of the Ptolemies shone forth as a beacon to the nations around, and, under the enlightened and liberal patronage of the Lagidce, Alexandria became the seat of the most distinguished school of antiquity. But mutability marks all human things, and Alexandria could only play her single part in the drama of the world. Under the Roman domin- ion, her commercial prosperity and literary preeminence were for a long time undiminished, and she continued to afford the finest medical school in the world, until near the fifth century of the Christian era. The first great blow that was inflicted upon her literary prosperity was the burning of her immense library during the siege of Julius (Vsar, a blow lameiittable for Alexandria and the world then, lamentable for litera- ture and science through all time to come. Only slowly and partially was that shock recovered from through the subsequent efforts of the friends of learning, among whom not the least efficient was the frail, the beautiful, but noble, Cleopatra. Through her instrumentality the library of Pergamos was removed to Alexandria, and still this academy was thronged by the votaries of science, from every quarter of the civ- ilized world, and still she sent forth the most distinguished philosophers, mathematicians, and physicians of the age, until that second conflagra- tion, by Christian fanaticism, which at once and entirely swept off that great collection of books, the work of ages* Then perished the glory of this unfortunate city—then went out the light from this source, and left a darkness whose gloom extended through centuries afterwards. But medicine was not, could not be extinguished. I have said that we may be certain that whatever contains the elements of truth, and has for its object the benefit of mankind, and, moreover, an inevitable tendency to accomplish that object, however small and insignificant its beginning, and however great the obstacles it may encounter in its course, will be successful at last and attain magnificent proportions. Certainly, so far as I have traced medicine, this observation is verified. With an origin truly insignificant, with opposition as bitter as prejudice and supersti- tion could raise, with the blind assistance of friends, whose zeal effected often as much of harm as good, and with a work to be accomplished as difficult as ever tasked the talents and ingenuity of man, the course of our science has been nevertheless ever onward, ever forward, until now, when civilization may be considered as almost at its acme—when intel- lect, morality and integrity, form the basis of the standard of excellence__ when education is so universally disseminated among the masses—and when religion has shed its benign influence over so great a portion of the world, it holds the highest place in the estimation and also in the heart of the community. Where can Ave find stronger, where better, evi- dence than all this of the value and truth of any science? If it be not true, where shall we find such another instance of falsehood and error combatting successfully all opposition, rising to eminence, then almost overwhelmed, and again advancing in the face of the strictest scrutiny and investigation, the dispassionate examination of the learned, and *It isa disputed point whether the second burning of the library was as above stated or by the Arabs. I incline to the former opinion. 13 gaining the acknowledgment of the world? Mahommedanism can surely not be pointed to, for it has not passed so great a lapse of time, and pales before knowledge and education; astrology but shows the depth to which the untutored credulity of man may lead; while alchemy serves only to show the mingled avarice and ignorance of an age in which it could flourish. For three centuries and more after the first burning of the Alexan- drian library, little was done to advance the profession in any respect, and in anatomy absolutely nothing. Dissection was not only neglected, but pos- itively interdicted, and the teachers in the institute were satisfied to fol- low, blindly, the footprints of Herophilus and Erisistratus, who had been chiefly instrumental in establishing the celebrity of the Alexandrian school. The theories and teachings of these great masters were carried to the east and to the west; in the former throughout China, existing in a mangled state to the present day, and in the latter, after passing the alem- bic of Galen's genius, they were transmitted through many generations. During all the time between the first conflagration and the age of Galen there were but three or four individuals who really pursued anatomy ; but still the reputation of the Alexandrian school remained, and still its name stood foremest in the world. Transferred to the west, the science of medi- cine experienced a great impulse, through the genius and labor of Galen, Btyled the second, as Hippocrates has been called the first, father of medi- cine. Through him mainly is it that we are enabled to judge of the char- acter of those antique volumes, which had been so ruthlessly destroyed, while he himself has transmitted to posterity voluminous evidence of his own sagacity and industry. From this time we trace the progress of med- icine through the regular channels of history, and can delineate with accu- racy the different phases through which it has passed to the present day, and, so tracing, we find that it still affords the same evidence of its truth, and the same evidence that truth, essential to the comfort and happiness of mankind, cannot be obliterated. If time allowed, it would be easy to show that the science of medicine experienced as many and varied attacks during the period just considered as it has at any time in its history, or does at the present day; and it requires no great depth of reasoning to prove that the incapacity of any and all of these to arrest its onward march, but affords additional evidence of its truth. My reference to the history of medicine from the Christian era to the present times must necessarily be brief. At a casual glance, everything would appear most propitious for the ad- vance of medicine, immediately upon and after the advent of our Saviour. But a closer examination will satisfactorily explain the condition which we find to have gradually prevailed and endured till the revival of letters. The Roman Empire had swallowed up all minor states; the Barbarians, who had been constantly hovering upon, and frequently passing, in hostile array, the insufficiently guarded frontiers of the republic and empire, were either re- duced to subjection or elevated to a participation in the state; and univer- sal peace had ushered in a condition of affairs that the world had never before witnessed. Surely it would seem that here was precisely the state of things, beyond all others, most propitious for the advancement of a sci- ence so eminently calculated to benefit mankind. Why was it otherwise? There are two principal reasons, besides other circumstances not essential to be mentioned. First, it was natural, as extremes are apt to follow each other, that, upon the introduction of true religion, the minds of the con- verts from paganism and idolatry should be imbued with a violent abhor- rence of all things having any connection or relation with their old system of worship. Thus were they led, in the first enthusiasm of their conversion, to undervalue medicine, which had been taught in heathen temples by heathen philosophers, while, with a misguided faith and trust, they depend- ed upon the direct assisUnce of the Deity in all things, without availing themselves of the aid of his appointed agencies. Moreover, theological die- 14 cussions and controversies engaged so large a share of public attention as for a time to silence all other investigation, causing neglect of medicine and other sciences, and, at a later day, leading to those errors and abuses in re- ligion which gradually overwhelmed the church and introduced an idolatry scarcely better than the ancient worship of the heathen gods. Secondly, the high position which medicine had already attained, and therefore the lucrative inducements it thus held out, had attracted, as it has in our own day, swarms of traders in the profession, whose only object, first, last and always, was money. These vampires, as we see around us now, threw discredit on a profession which, above all others, demands self-denial, honest effort, and true philan- thropy. But the very evil which was thus created, becoming in time entirely insufferable, worked to some extent its own cure. At an early period of the Christian era, certain wholesome restrictions were imposd upon the prac- tice of medicine, and Antoninus Pius originated a system of protection for the community, which might most advantageously be imitated at the present day. Under this rescript no one was allowed to practice who had not, by examination and otherwise, exhibited capability and good character. How such requisites would now curtail the number of doctors and how the com- munity would be blessed ! But although during the early part of the Chris- tian era there was no rapid extension of medical knowledge and discovery, there was nevertheless a step toward the establishment of a broader and surer foundation for its future growth and prosperity, while its passage through, and revival of, the period extending to the fourteenth or fifteenth century, and termed very properly its "period of transition,"* go far with all candid and reflecting minds to establish the value and truth of the sci- ence. But if medicine suffered through the abnormal application and influ- ence of Christianity in one direction, in another, and through its natural, healthy and legitimate tendency, it experienced a valid and lasting aid, which gave and gives assistance to its advance by the sure and reliable light of clinical observation. To the proper appreciation and application of that rarest and most Christian of all virtues, charity, is due the establish- ment of hospitals, by which was gained a systematic observation and treat- ment of disease, and an opportunity of testing theories which, instead of preceding, should always follow, facts, only to explain what experience has already established; and to the effort of woman, ever more ready than the other sex to sympathize with, and alleviate, the sufferings of humanity, is attributable the origination of that happy idea, the establishment of hos- pitals. A noble Roman lady, led by devotion to religion to take up her abode at Jerusalem, was touched with pity at witnessing the sufferings from untreated disease among the crowds who visited that city for the purpose of beholding the spot and scenes hallowed by the bodily presence and death of their crucified Lord, and, to relieve them as far as possible, she united with a few others, under the direction of St. Jerome, in the erection and maintenance of a hospital for the sick, and another receptacle for the con- valescent. This system was further enlarged and acted upon at a subse- quent date by Emperors and Kings, and thus that which was the conception of the purest charity and benevolence resulted in great and lasting benefit to the science of medicine. Among the writers of the period extending from the third to the four- teenth century there is but little mark of originality, most of them being content with blindly following in the footsteps of their predecessors, and especially Galen, the last of the Latin authors who made contributions of any extent to our science. For several centuries after the time of Galen there were only three or four authors in the western empire whose works have been deemed worthy of preservation^ Serenus Sammonicus, Theo- dore Priscian, Marcellus Empiricus and Vegetius are the last writers of note before the second burning of the Alexandrian libraries, and their con- *:Renouard. f Watson's discourse. 15 tributions are in no way comparable to those of Galen. The first of these, Serenus Sammonicus, was indeed almost a cotemporary of Galen, being in the zenith of his success and reputation during the reign of the infamous Caracalla. Although the Christian era had already dawned and was shedding its heavenly light more and more brightly over the world, still idolatry and su- perstition were far from having lost their hold upon mankind, and the most enlightened physicians, however skilled in medicine, yet resorted to the fancied assistance of charms and amulets. Sammonicus is said to have been the author of that celebrated collection of letters, Abracadabra, which was arranged in the form of a triangle, and suspended around the necks of fever patients, which has outlived all the changes and improvements of after years, and is now familiar to thousands to whom the names of Sam- monicus and Caracalla are utterly unknown. Such continued to be pretty much the condition of medicine during the first three or four centuries of the Christian era, while the irreconcilable contest between paganism and Christianity was being waged, and which waned not until the reign of Con- stantine, when the latter became formally the religion of the State. During this same period the Greek schools were gradually elevating themselves, and a few celebrated names from among them have come down to us, as Oribasius, iEtius, Alexander of Tralles, a city of Lydia, and Paul of the isle of iEgina. Under the Christian Emperors, medicine experienced a healthy stimulus, and the heathen temples were finally closed, the buildings converted into hospitals, and their possessions devoted to their support. The nobles, both gentlemen and ladies, lent assistance to the work, and while charity was thus extended to the suffering, these institutions served as admirable schools for the rearing of teachers for the great number of students who were devoting themselves to this science. The greatest emu- lation sprung up between the different teachers and their pupils, leading to the most extravagant electioneering exertions, and presenting a picture which will be readily appreciated by those who have the opportunity and misfortune of witnessing the excellent imitation of the present day. Amid the wreck of empires which soon followed medicine still existed and slowly grew. The empire of the west gradually succumbed to the hordes of barbarians which ceaselessly poured upon it from the forests of Germany, and from its ruins arose the separate and independent kingdoms of the Francs, the Visigoths, and the Lombards. The empire of the east still struggled for existence, and, though displaying remarkable heroism and vigor, saw her strongholds falling, and her frontiers gradually con- tracting around her. The Turks, in one direction, were pressing her sorely, and her old enemy, the Persians, in another, kept up their incessant annoy- ance and encroachment, when a more remote, more terrible, and most unexpected foe from the deserts of Arabia precipitated his bands with resistless impetuosity, first upon the more distant, then, emboldened by success, upon the nearer provinces, and finally wrested from her hold the fairest possessions of the empire. Egypt, Syria and India, at an early day, fell under the dominion of Mahomet and his successors, while but a century or so more sufficed for the extension of their arms into the European provinces and the establishment of their sway from the Indus to and over the Spanish peninsular. While we are accustomed to look up this prophet conqueror as an am- bitious fanatic and rapacious adventurer, we at the same time should re- member that he and his successors gave great encouragement to the arts and sciences' inviting the learned of all countries to take up their abode among them, and bestowing such solid favors as attracted many men of merit and learning to their dominions. The cause, therefore, of the downfall of literature in the west was the occasion of its transference to and reestablishment in the east, where also the science of medicine was prosecuted with a good deal of success, and where soon appeared 16 physicians and writers who have transmitted valuable information even to our own times. The Arabs made many useful discoveries in the ma- teria medica and chemistry, which seemed to possess especial attraction for them, and in literature and the arts advanced far beyond all sur- rounding nations. It is impossible to conceive that a science which was not essentially true could thus have continued to progress under almost every turn of fortune, and have commanded the belief of the ablest and brightest in- tellects of every age. and true as opposed to all the different forms of quackery which either now, or heretofore, have imposed on human cre- dnlity. Of all the names of antiquity, among all nations, none occupy a higher place than those who have given their lives, labor and faith to medi- cine. Among the Arabians, Rasis, Haly Abas, and, above all others, the noble and gifted Avicenna, Albucasis, and many others, have transmitted to posterity the evidences of their ability, and afforded us a clear insight into the condition of the medical science. The Arabian princes estab- lished hospitals and schools at an early date in the east, and in Europe, when masters there, whatever havoc in other respects they committed, in regard to the arts and sciences, they pursued an enlightened policy of protection. But when the Turks succeeded in wresting from them their hard-earned power, they struck, as they have ever done, a fatal blow at all that tended to elevate humanity. During all this period, among the Greeks and Latins, the science of medicine, if it did not actually retro- grade, at least made no perceptible improvement, and as thus both in the east and west the supports of knowledge and science were failing and fading away, a new agent became necessary to stir the stagnant pool of human intelligence. That, agent already existed and was ready for the task. As the prim- itive church lost more and more of her original purity, she made more eager clutches at the acquisition of control over the property, conscience and education of the people, and as good not unfrequently grows out of evil, the means adopted for her own aggrandizement proved most effect- ual for the promotion of the sciences and liberal professions. About the cathedrals colleges were established, where medicine, to some extent, with what was known of other sciences, was taught, and gradually the knowledge and even the practice of medicine fell almost entirely into the hands of the clergy. After the ninth century, they met with suc- cessful rivals in the Jews, who then, as now, being much given to com- merce and traveling, were thrown, by the nature of their pursuits, among the Saracens, who still stood foremost in civilization, and from whom they acquired more valuable knowledge, and a better system of practice, than yet prevailed in the west. But the information of the wisest and best of these practitioners was exceedingly limited, and their success indifferent, while their remuneration was so far disproportionate to their services, that numbers of quacks, ignorant even of the little that was then known, were attracted to the profession simply and entirely for its gains. The evil became intolerable, and, as a remedy, Theodoric, king of the Visigoths, established laws for the protection of the people' which remained in force for several centuries. These laws are curious' and some of them would be productive of good were they enacted now! One of them provided that, if any of these irregular practitioners should injure a gentleman, he should forfeit a heavy fine; and if, by medicine or a surgical operation, he should cause death, he was to be handed over to the tender mercies of the relatives of the deceased, who might deal with him as they thought proper. In regard to the relation of the church to education and science, whatever may have been the object of the clergy it cannot be denied that they were largely instrumental in preparing the mind of Europe for the intellectual movement which followed the 17 fourteenth century. Prior to this time, as has been observed, the Sara- cens were at the head of civilization, and had established, not only in the east, but also in the west, colleges and schools of medicine, some of which attained extended celebrity, and long outlived the downfall of the Saracen sway. Among these none stood higher than the school of Salernus, established, as is believed, by refugees from Alexandria after the final destruction of the great libraries. Patients from all parts of Europe flocked to Salernus, to avail themselves of the skill of the faculty there, and even so late as near the beginning of the twelfth century this school still stood so preeminent that many of the wounded crusaders of distinc- tion stopped there to be treated, among whom was Robert, Duke of Nor- mandy, son of William the Conqueror. Thus, amid all vicissitudes, against all foes within and without, amid the rise and fall of empires, through an age of darkness, when almost everything not essential for man was obliterated, not only had medicine maintained an existence, but it had established a conviction of its truth in the minds of all the most intelligent and enlightened of Europe, Asia and Africa. My time does not allow me to dwell minutely upon its history, to speak at large of the temporary and changing circumstances which ex- ercised an influence over its progress and condition at different periods, to explain the causes which led to a separation of medicine and surgery, or even to mention the character of the latter, which indeed would be more amusing than instructive; nor is all this essential to my purpose. I proceed to a brief consideration of the subject after the commencement of that intellectual dawn, appearing about the fourteenth century, wax- ing brighter and brighter through age after age, and in our time shed- ding its noonday blaze over the world. The crusades were past which had given so vast an impulse to civilization, and the fruits of them were seen in the establishment of new and enlargement of the existing uni- versities and schools. In Germany, in France, in Spain, and m Eng- land, universities were established which exist to the present day, and which will no doubt continue through all time to come. The telescope, the microscope, the compass, and, above all else, the art of printing had been invented, and, what more directly concerned the study of medicine, the superstitious dread of interfering with the dead human body, which had been an impassable barrier to the prosecution of anatomy, had been dissipated, and dissection was soon licensed, or at least permitted, by the removal of the interdict of the Church of Rome. Poetry again re- vived, and a Dante, a Petrarch, a Boccacio, and a Chaucer were born to rekindle a taste which had been smouldering for ages. Let me, at this point of the world's history, again ask, what would have been the nat- ural influence of this intellectual revolution upon the progress of medi- cine if it were not a science of truth? Old superstitions were aban- doned old theories reviewed and remodeled, and old ideas, which could not stand the test of scientific investigation, quietly sunk into oblivion, while medicine did and does live, because it can stand this test. As we follow the course of medicine for the last four or five hundred years we find the same kind of record that characterizes the history of all other sciences, namely, gradual correction of error and improvement in the practice. We find men of the highest order of talents devoting those talents to honest investigation in our science, and giving to the worm the benefits of their discoveries and experience; we find at the same time barriers to the advance of the profession, similar in kind, it not equal in degree, to those that clog its progress now; we find, in short, at all times quacks and mountebanks ever ready to avail themselves of the credulity of the people. It is true that as the world advances there must be new methods of humbuggery invented; for the public taste, be- coming more and more morbid in this aspect, requires more stimulating frauds and the new species of quackery that are constantly springing 18 up, for any hope of success, must each in its turn outstrip its predeces- sor in audacity and absurdity. Humbuggery, to succeed at the present day, must be monstrous in- deed; the public taste demands it, and there are always ready those to furnish it. But the same kind of thing, though not equal in degree, has always existed; and is this the ground on which is rested the question of the truth of regular medicine? Are these the witnesses to be appealed to or to be opposed as rivals to the science of medicine? The evil will no doubt continue to increase in magnitude, until it becomes intolera- ble; but when this point is reached the people must find out for them- selves. In the meantime the members of the medical profession can only prosecute honestly and honorably their calling, for any effort on their part to arrest these evils will at once be met with the cry of persecu- tion and self-interest. The good, however, which has been and is being ac- complished stands forth as incontestible evidence of the value and truth of medicine. . . In the cause of humanity, we may point to the examples of physicians as in the highest degree noble and glorious. To go no further back than our own times, and in our own country, instances, and those not a few, of the most admirable heroism have been exhibited—heroism not excited by desire or expectation of human applause, but prompted by the highest be- nevolence and philanthropy. In New Orleans,* in Philadelphia,* in Nor- folk * in our near neighbor, Cincinnati,! and inSandusky,t when all others were flying before the march of death, in the hour of gloom and despair, in the face of danger,before "the terror by night, the arrow thatfliethby day, the pestilence that walketh in darkness, and the destruction that wasteth at noonday," have these devoted members of our profession stood to oppose all their energy and power to the progress of the destroying angel, to soothe the sufferings of the sick, to moderate the agony of the dying, and alas! too often to sacrifice their own lives in the defence of others.J The atten- tion of the profession has also been directed to the prevention as well as the cure of disease; and their success in this respect fully attests the value of their services. The plague has disappeared, small pox has been dis- armed of its virulence and terror, while the mortality in large cities and in hospitals has relatively diminished, as is proven by the statistics of Eu- rope and America, and longevity has increased. The field of battle, too, has participated in the benign influence of the medical science; wounds, formerly mortal, are cured, and the dangers of a campaign, both from en- gagements and the sickness incidental to camp life, are greatly diminished. Boards of health have been established, and, under their direction, sanitary regulations have been adopted, which have abated the frequency and fatal- ity of pestilences. All this, and vastly more, has been the work of medi- cine—of regular medicine—of a science which arose from the necessity of man, which continues because that necessity continues, and which must continue until that necessity ceases to exist; which has been handed down from the remotest periods of antiquity, relinquishing error as error is proven, advancing as light is added to light, and which is opposed to char- latanry and quackery of every sort and description. The good—the great good that it has accomplished, and is accomplishing, is undenied and un- deniable; while in its pursuit are engaged vast numbers of the most intelligent, the most scientific, as well as the most honest of men, all of whom are either deceived and wrong, while the followers of the differ- ent seisms, the growth of yesterday, or of some one of them, are right; or these same men, intelligent in every other respect, afe duped in this; or, honest in all else, are here practicing a fraud upon their fellow-men, if medicine be not a science true, and worthy of belief. It is very much the fashion of the present day to underrate the great value to our profession of the experience of ages; and well may the en- :|,Yellow fever. f^-holera. JMarny physicians died at Norfolk. 19 emies of that profession foster and encourage such a fashion; but cer- tainly any intelligent mind that will reflect upon the subject must see, and every honest one admit, the necessity of this experience in our call- ing far more than in any other business or profession. In any and al- most every other science, experiments of the same kind exactly, and under precisely similar circumstances, may be indefinitely repeated for the establishment of certain and constant laws, but in medicine it is far otherwise. Our agents, subjects and circumstances are continually va- rying, so that the lapse of generation after generation is requisite for the repetition of experiment and observation, under circumstances suffi- ciently identical, to elucidate and establish a single therapeutic rule. Thus, as has been aptly remarked, the past is a giant upon whose should- ders each succeeding generation may mount and gain a view which, without such aid, would be impossible; and thus is it evident how pre- posterous and presumptuous are the pretensions of him who would un- dertake in medicine, by the experience of one or even a hundred indi- viduals, to establish a system of practice in opposition to the experience of the past. But that this has been repeatedly attempted the history of the past informs us; at which we surely should not be surprised, since even the religion ordained and revealed by the Creator himself has not escaped the innovating touch of the creature.