OZONE 
OR 
ELECTRO-NEGATIVE OXYGEN 
AS A 
NATURAL AGENCY 
IN THE VITAL PROCESS,. 
° 
ITS APPLICATION IN TIIK1IA PEL TICS 
BY 
DR. THEO. A. HOFFMANN. 
BEARDSTOWN, ILL. 
H. A G. A. RAUTH, Steam Printers, 200 Market St. St. Louis. 
1873. OZONE. 
When after continued dry and sultry weather “in which 
a sensation of heaviness and debility is creeping upon 
man, when even the plants hang their leaves, buds and 
blossoms as if mourning towards the ground”, a cool rain 
and a thundershower sets in, purifying the air nature re- 
vives, man breathes more freely, the plants lift their 
leaves, buds and blossoms towards the bright sunlight, 
and everything is new life again, such is the effect of 
“Ozone or Ozonized Air” produced by the electric change 
and the current in the athmosphere, for which man, animal 
and plants have languished as a part ol their nourishment. 
Professor Meissner in Goettingen says : Of all the great 
leading inventions in chemistry the most important 
is that of Professor Schoenbein, showing that Oxygen 
exists in three different forint : 1) as indifferent or chemi- 
cal-inactive Oxygen, 2) as AutoZone or active electro-posi- 
tive Oxygen, 3) as Ozone or active electro-negative Oxygen. 
Our atmosphere is composed of 7!) Nitrogen and 21 Oxy- 
gen with a slight fraction of carbonic acid gas. 2 
The Oxygen of the atmosphere is itself inactive Oxygen, 
and the activity of the same depends upon the quantity of 
Ozone it contains, this quantity depending on the electric 
current in the atmosphere. The richer the air is with Ozone, 
the more favorable it is for the vital process ; the poorer 
with Ozone, the less favorable it is for our health. 
By the process of respiration—Ozone is partly formed 
in our lungs as an essential agent of our vital process, 
and the best nourishments would remain inactive for as- 
similation, if Ozone, a certain quantity of which the saliva 
carries to the food, were wanting. 
Oxygen or Ozonized Oxygen keeps up the warmth 
in our body, it is the source of force or action for our res- 
piratory and alimentary process. In high plateaux 
(mountains) the air is richer with Ozone than in low places 
or crowded cities. 
If the quantit}’ of ozonized air to be taken into our 
system, is reduced to a certain minimum, disease will be the 
consequence, such as: difficulty in breathing, spasms of 
the respiratory muscles, sleeplessness, delirium, dilatation 
of the pupils, asthma, suffocation, paralysis of the heart.— 
The effects of the inhalation of ozonized air or ozonized 
oxygen are mainly: moderate pulse and respiration, in- 
crease of appetite, removal of costiveness, acidulated pleas- 
ant taste in the mouth, sleep, absorption of exudations. 
The inhalation continued for longer periods will produce 
flushing rosy cheeks and lips, good complexion of the wrink- 
led skin ; hairs which fell out will grow again, pimples and 
freckles will disappear, the weight of the body will increase ; 
fever, inflammation, spasm, palsy will disappear more or 
less, or subside entirely. In short, the influence of a pur- 
ified arterial blood will show its blessings through the 
whole system of the body, in so far as the sickly affections 3 
of the organs can be removed or restored by the influence 
of a normal blood. 
It would be well to remark that an excess either in too 
often or too long continued inhalation of strong ozonized 
oxygen will produce nervous irritability, perspiration, in- 
satiable appetite, etc. Therefore the use and the time of 
inhalation should be under advice of a physician.—Still 
ozonized air can be introduced into the system without 
injury, the blood globules absorbing the same. Ozone or 
ozonized air can not be compared with, or ruled in the 
same classification as Kreosot orCaibolic acid, which have 
been tried as purifyers of the circu’ating blood in vain. 
The cause of the unsuccessful results with those remedies, 
is that they are in themselves, and in their products of 
decomposition entirely heterogeneous to the assimilation. 
Those suffering with emphysema ol the lungs, chronic 
bronchial catarrh, diseases of the heart, have generally a 
pale complexion from the venous condition of the blood, and 
will be very much benefited by the inhalation of Ozone or 
ozonized air, and life can be considerably prolonged by reg- 
ular application. In the like manner we can explain the 
good and successful results, obtained from the inhalation 
of ozonized oxygen or ozonized air in the treatment of 
spinal affections, (tabes dorsalis), articular rheumalism, 
glaucoma, in atrophia of the optic nerv, farunculosis. gout. 
There might be objections raised by some physicians, and 
would-be physicians, to the use of Ozone or ozonized air, 
and when they are founded on real facts they should be ac- 
knowledged, still the controversy must not remind us “as 
Professor Meissner in Goettingen says” of the words : 
“What you don’t weigh, that has no weight for you ; 
What you don’t coin, you think it is not true.” 4 
Eminent physiologists have declared, that the applic- 
ation of gases as effective curatives will have a great 
future, and in the Ozone or ozonized air we find the great 
agent, which nature has provided for, (if ever so little) in 
our atmosphere to be received in our lungs, and if circum- 
stances demand a larger supply for the weary and diseas- 
ed, it is in our power to satisfy the demand. The dimin- 
ishing of the contageous influence in epidemics, as cholera, 
yellow fever, typhus etc., after a heavy thundershower, 
where Ozone is formed in the atmosphere, speaks for the 
good effects of the application of Ozone in those diseases. 
We observe a curative influence in the neighborhood of 
Salineworks in scrofula, while travelling on the sea by those 
suffering with tuberculosis, in staying on high plateaus by 
persons having intermittent fever, when stiring much in free 
air by those suffering with ehlororis, sickheadache and 
hoopingcough. This influence is caused by inhaling an air 
richer on Ozone, than that in dwellings, and the appli- 
cation of Ozone either as inhalation, or drinking of water 
saturated with Ozone, has given very successful results 
even in cases where strong doses of quinine could not ac- 
complish the cure. 
The light of the sun and electricity are the great agents 
for sustaining life in the animal as well as in the vegetable 
kingdom, even the minerals undergo transformation by its 
influence. Plants and animals depend on oxygen for their 
existence. Under the influence of sunlight the plants absorb 
carbonic acid gas from the atmosphere, and exhale oxygen 
in day-time, so beneficial to men for respiration, during 
night the plant absorbs oxygen and emits carbonic acid gas. 
According to Prof. Traube & Pfliiger, the excess of car- 
bonic acid gas is fatal, causing symptoms of suffocation ; 
exactly the same takes place by a deficiency of oxygen. 5 
Carbonic acid chemically combined with ammonia, when 
accumulated in the blood, will kill with the symptoms 
similar to those produced when death is caused b\ freezing. 
Of great significance are the cryptogamic‘ spores or 
microscopic fungics which are floating in the air we inhale ; 
they play an active part in our vital process. A great part 
of it may be essential for sustaining the same ; an other 
part may be inactive or little molesting, another part of 
it is dangerous to our health by disorganizing our blood, 
acting as a germ in diseases (generally termed malaria 
or miasma). Those septical organism: mould, fungic, 
bastaria, • vibriona, zoogloeema etc., or as they may be 
termed by classification—will accumulate when the con- 
ditions for their development in our system are favorable, 
as for instance, badly ventilated sickrooms, decay and 
putrifaction of vegetable and animal matter, stagnant 
water and air, want of sunlight, marshy low places, 
densely crowded dwellings with accumulation of filth. 
Professor Danzer obtained by washing 2495 litres 
(quarts) of air of the city of Manchester (England) with 
distilled water a liquid, which contained 37£ millions of 
cryptogamic spores and fungics. Those 2495 litters air is 
the average quantity which a middlesized man will inhale 
in ten hours.—Besides this the air of Manchester contains 
in 100,000 parts about 25 parts sulphuric acid. 
The air is generally deprived of Ozone in all places 
which are the hotbeds of those miasmatic organisms, and 
the bad influence of the same may be destroyed by the in- 
halation of ozonized air. The wise arrangement of nature 
to prevent a great part of those microscopic bodies or 
fungics from entering into the circulation, consists in the 
function of the epithelia and the vibratory and ciliary 
motion of the same, to take hold or make them adhere to 6 
the mucous membrane of the respiratory organs, and 
throw them out by sneezing or coughing. 
Professor W. Kuhne (Schulze’s Archiv for microscopic 
anatomic 11, pages 372—378) has stated that the motion 
of the cilia will be checked when the air is deprived of 
oxygen, while their motion is directly revived as soon as 
oxygen or ozonized air is admitted. That even larger or 
visible bodies can be carried into our lungs by respiration 
has been proven by several physiologists.—Professor 
Traube found fine particles of charcoal in the lungs of 
persons handling this article extensively. 
Tigri, Coze, Houson and Lueders have proven by direct 
examination, that cryptogermic fungics are carried into the 
circulation of the blood. The good and fresh complexion of 
the inhabitants of sunny elevations, an 1 the sallow faces of 
the dwellers in low districts and cellars give a clear state- 
ment of the influence of oxigen or ozonized air on our 
system. The quality and the quantity of those septic or 
miasmatic organisms brought in circulation with the blood, 
will develop different diseases in our body, as : fevers of 
various nature, enlargement of t he spleen, depression of the 
nervous system, affections of the respiratory organs, ros- 
eola (rosetrash), initial bleeding, diphtheritis, cholera, 
puerperal fever, yellow fever, dysenteria, catarrhus, cerebro 
spinal meningitis, paralysis, exanthemic diseases etc. 
The antiseptic qualities of quinine are well known and 
acknowledged, and it is an erroneous view to ascribe the 
origin of dropsy, softening of the brain, enlargement of 
the spleen and liver, to the use of quinine, which the 
practical observations by the writer (author) for the last 
4 decennaries can confirm. Those diseases appear frequently, 
when the character of the fever is suppressed by small or 
insufficient doses of quinine, yet the influence of the malaria 7 
or the septic germs in the blood not yet perfectly removed, 
and will be the cause of congestion in one or the other part 
of our body, which generally yields to the application of 
energetic doses of quinine in proper shape. 
We have in Quinine and Ozone two powerful antagon- 
istic remedies to check the developement of those mias- 
matic cryptogermic spores, fungics or septical germs, to 
destroy the same or make them harmless. While those 
germs exist and develop at the expense of the oxygen 
in our blood, an addition of ozonized air into the circu- 
lation of the blood will restore the same to its normal state. 
Professor Binz considers quinine as a strong ozonizing 
agent. 
A current of ozonized air conducted into water, will 
make the infusorial animals (monada) at first motionless 
and afterwards destroy them entirely. A current of ozon- 
ized air into a foetid liquid blood will restore the original 
smell. 
Concentrated Ozone is not well applicable for inhalation, 
being too energic, in the same manner as alcohol of 95 de- 
grees is not fit to be applied as medicine without dilution. 
Ozonized air should not be stronger, than that it may be 
inhaled without producing cough ; a grown man might 
inhale from 25 to 100 quarts per day without danger. 
100 litres (quarts) atmospheric air contains about 0,01 
to 0,02 milligramme Ozone. (Prof. Ludwig). Accord- 
ing to Prof. Genth, Ozonized air will give the best relief to 
persons suffering with gout. Prof. Ludwig Boelime considers 
cholera a desquamative acute catarrh of the intestines ac- 
companied with microscopic fungics. An application of 
ozonized air by the mouth, and ozonized water concentrat- 
ed as injection, might give the practitioner a more effective 
reined}7 on hand than all others known. 8 
Ill poisoning with gases, such as sulphuretted hydrogen, 
carbonated oxygen gas and others similar. The application 
of Ozone should be preferred before any other reine ly. 
Pristly & Scheele discovered the oxygen anno 1774. 
Five cubicfeet atmospheric air contain one cubicfoot 
oxygen and four cubicfeet Nitrogen. Oxygen has a greater 
specilic gravity than atmospheric air. 
The density of Ozone is 1,50 to oxygen. Oxygen will 
remain in a gaseous form by a pressure of 58 atmospheres, 
and a temperature of 139 degrees Fahrenheit below Zero. 
Farraday. 100 volumes of water will absorb 3 to 4 vol. 
oxygen by the height of the barometer of 7G0 cent. metr. 
Ozonized air or oxygen changes the color of the dark venous 
blood into high red. The same change takes place when 
animals inhale oxygen gas ; and one vol. of oxygen gas will 
sustain life four times longer than the same vol. of atmos- 
pheric air. 
According to Schoenbein, manganic acid and chromic 
acid contain electro-negative oxygen or ozone, therefore 
called by him ozonides. Ozone mixed with athmospheric 
air will produce no inflammation of the lungs. According 
to the same author and others, Albumen milk, the fibrine 
and globules of the blood will absorb Ozone freely. Also 
powdered carbon (charcoal). 
In the city of Paris (France) are 19 stations, where 
Ozone contained in the atmosphere is measured. 
According to Alex. Schmidt. The normal blood actually 
contains Ozone. 
Ozonized air has been inhaled for twelve weeks with 
-comfort and without effects of coughing or signs of inflam- 
mation. Ozonized oxygen will effect Indian Rubber, and 
it will soon loose its good effects, when kept in indian 9 
rubber bags. The best way to use Ozone for inhalation 
is in its nascent state. 
According to Prof. Kuehne. The blood globules are 
carriers of Ozone, and act on tests, sueh as iodide of 
potassium, tinct. of guajae. 
Pile absorbs Ozone energetically. 
The importance of the inhalation of ozonized air in jaun- 
dice, gout, oxalic acid diathesis, is mentioned by Goroup 
and Besanog. 
According to R. Richter, arrow poison in watery solution 
is decomposed by a current of ozonized air. 
According to Blanche, Taddei, Schoenbein. Plants 
contain Ozone. 
According to Garrod. the inhalation of 28 litters of ozon- 
ized air twice a day, produced relief in acute gout. Eek- 
hardt considers the inhalation of ozonized air in gout as 
sufficient without any other remedy. C. Paul, Husemann, 
Herman and others recommend the inhalation of Ozone 
in cases of poisoning with opium, sulphuretted hydrogen, 
carbonic oxyd gas, etc. 
Ferd. von Arnim, inhaled for two days 150 quarts of ozon- 
ized air each day, for the two successive days 180 quarts 
each time, and the fifth day 250 quarts with good effects. 
The origin of Ozone or ozonized air in our atmosphere 
is stated in the foregoing. The quantitative variation of 
it depends on the meteorological influence, and in certain 
circumstances this quantity of Ozone may be reduced to 
Zero. Ozone or ozonized oxygen is formed in the electric 
current of a galvanic or electric battery in diverse oper- 
ations, representing the electro-negative oxygen. 
It is also formed in various chemical actions. The 
difficulties of the diverse ways to produce Ozone cheaply 
and conveniently have checked its practical application for 10 
general use more or less. By my lately patented process 
I have succeeded to produce Ozone or ozonized air in a 
cheap and practical manner, to enable physicians or med- 
ical men to apply the same, whenever circumstances de- 
mand it in its nascent state, mild or strong, or in local ap- 
plication as Spray by attaching an atomizer. 
The foregoing statements of expert practitioners and 
eminent Physiologists, will give encouragement to the ap- 
plication of this great and valuable remedy, which nature 
lias provided for the vital process under the laws existing 
from the beginning of the world, yet unknown to men, be- 
fore we were advanced in science far enough to decypher 
gradually the concealed and secret rules existing in the 
great immensurable universe, and so we advance step by 
step in the developement of science for the benefit of man- 
kind, that will give us a right to claim that man is the 
most superior and most important being dwelling on this 
insignificant but eventful and progressive world. APPENDIX. 
The peculiar quality, that albumen or albuminous bodies 
absorb Ozone freely, has given impulse to the technical 
application of Ozone to fresh fermented liquids, after the 
same have got through what is technically called : “the 
first fermentation and separated from the 3’east.â€~ The 
wines in this state even if clear in appearance, have still 
albuminous bodies in solution, which in the warm season 
will produce a second fermentation. Those bodies will be 
oxydized by Ozone, and more easily separated, and thus 
the wine ripens in a shorter period, acquiring at the same 
time a finer bouquet (flavor). The good results of this 
practical application, and the easy manner in which it 
can be performed, will give this method the preference to 
that of “Pasteursâ€~, which consists in heating the wines to 
a certain degree in order to destroy the effects of those 
fermenting bodies, by which however a part of the fine 
flavor will by destroyed also. Alcoholic liquids or distill- 
ed liquors treated with Ozone will improve in a short time 
in the same manner as by age if stored in warehouses for 
several years in barrels with open bungholes so as to absorb 
the small quantity of Ozone in the air, losing in this way 
considerable, by evaporation, in quantity, also the interest 
on the invested capital.