THE NEW & ONLY SUCCESSFUL TREATMENT OF CHOLERA: WITH HINTS TO MEDICAL MEN, AND INSTRUCTIONS FOR EVERY FAMILY, BY A. FENNINGS. LONDON : PUBLISHED BY GEORGE PEIRCE, 310, STRAND. [Price Sixpence.'] THE NEW & ONLY SUCCESSFUL TREATMENT OF CHOLERA: WITH HINTS TO MEDICAL MEN, AND INSTRUCTIONS FOR EVERY FAMILY. A. FENNINGS. LONDON: PUBLISHED BY GEOEGE PEIRCE, 310, STEAND. [Price Sixpence.] PRECAUTIONS. Never be exposed to the night air, because the atmosphere is then in its most negative, and least electrical, state. Do not eat raw vegetables during the Epidemic, because the system is then deficient of nervous power, and insufficient to digest them. Strive against fear, because fright always depresses the vital energy of the body. Do not commit excesses, because the subsequent weakness which naturally ensues, invites an attack. Neither fast too long, because it debilitates the whole frame. Take occasionally acidulous drink, as Lemonade, or a few drops of Vinegar in a glass of water; because acids purify and give oxygen to the blood, strength to the sensorium, and have, without exception, been found the most beneficial class of remedies, in all Epidemics, either of Plague, Cholera, "Yellow Fever, or any other scourge of man. A pious reliance on the Providence of God should be encouraged, because a meek resignation to His will is not only a duty, but a fine sedative to a perturbed mind. DIEECTIONS FOR TAKING THE EEMEDY WHEN SEIZED WITH CHOLERA. For an Adult the dose is a wine-glassful to be taken every two hours, until the person is better ; if the first dose is vomited up, the dose must then be repeated in a quarter of an hour. No Brandy, Spirit, Water, or any Liquids to be given, but a tea spoonful of warm Gruel, Tapioca or Sago, every 15 minutes. Flannels heated by the fire or hot water bottles, to be applied to the Hands, Feet, and Stomach, and friction along the Muscles, Sponges filled with hot Vinegar to be placed in the Armpits, and strong Aromatic Vinegar, combined with Camphor, occasionally given to smell ; the Patients to be placed between warm blankets. If, when becoming better, the Stomach should be troubled with Wind, 15 to 20 drops of iEther in a tea-spoonful of Gruel will relieve, succeeded by a small dose of Powdered Rhubarb. The Diet for two or three following days to be strong broths. To Prevent Cholera, Typhus, and Yellow Fever, Dysentery, Fluxes> and other Contagious Diseases. A wine-glassful to be taken twice or three times a week on an empty Stomach. — For Children the fourth part of a wine-glassful. For Bowel Complaints, Dysentery, Yellow Fever, Fluxes, when Attacked. A dose to be taken twice a day until relieved, the diet to be strong broths, taken with the chill off. NEW AND ONLY SUCCESSFUL TREATMENT OF CHOLERA. Being in possession of the knowledge of the powerful effect and almost instantaneous benefit of that combination of Medicines called " Fennings' Cholera Stomachic Mixture," in resisting and curing those devastating plagues, the Asiatic and English Choleras, our philanthropy would have been gratified, and our duty performed, if, sacrificing personal interest and such pecuniary considerations, we had made known to the suffering public the minutige of its composition, in order that the Prescription for the Rich and the Dispensary Book for the Poor might have contained the means of recovery from this terrible malady. Such was our intention. But having seen numerous recipes as infallible restoratives published in the daily papers, without gaining credence for their efficacy, or being even tried, we became convinced that ours would have shared a similar fate ; and thus our pecuniary sacrifice would have been of no avail, unless confidence could have been previously established, under official medical superintendence, of the unerring efficacy of the Medicine in Cholera cases, every opportunity for doing which we should have been glad to have embraced, and eager to have facilitated ; for, by its a 2 Mo^l i oH 4 adoption, to have effected such vast amelioration in one of the most peculiar ills "flesh is heir to" would have produced to the feelings of humane hearts a mental fortune. To promote that desirable object, we wrote a letter to the General Board of Health (a copy of which will be seen in a subsequent page), but, with a reprehensible incivility, no answer was returned. We have since then stood by the bedside of the dying Cholera patient, and surrounded by others in all stages of the complaint, and have ineffectively stated the same wish and made the same promise. No, said the medical men, we have our own treatment and system of remedies — (poor system, indeed !) — and useless calomel has been given in vain for the hundred- thousandth time. Thus we are compelled to adopt a course of proceeding which probably, to the unthinking, may appear empirical, but which at least will be profitably accompanied with one or two useful hints. It is unnecessary to introduce space occupying cases, but truthfully to affirm that the blue and livid skin, the torturing cramps, the incessant vomiting, the exhausting purgings, the dreadful thirst, the fearful coldness of Cholera, have all disappeared, and the Health been restored, from taking two or three doses of " Fennings' Cholera Stomachic Mixture" at the period of seizure, and, also, to state that if a dose be taken twice a week, it will preserve the system and prevent any attack of this direful disorder. The subject is far too serious for burlesque, but truly the faculty appear now very weak in sanative resource — very deficient of knowledge — very unequal to their responsibility ; what differences in treatment, 5 what diversity of ideas, what opposite views taken of the Cholera — such confusion and indecision — that they should gladly embrace any sensible hint, welcome anything rational— for the barber of Bagdad has been more successful than they ! The General Board of Health recommends no vegetables to be eaten — the College of Physicians says eat them Some medical men say fear will produce the Cholera — others say it never can do so. One advises as a cure castor oil — another protests it will give the disease. One exclaims that tobacco smoking induces Cholera — others recommend it as a preventive. One recommends bleeding — another, transfusion. Some give stimulants, as brandy — others, chloroform, oblivious of its congestive tendency. One, hot water — another, cold water. Some, plenty of liquids— others, fluids on no account. Many say, give calomel and opium ; thousands take it — thousands die — 'tis then discovered that opium destroys the power of calomel, as children perceive chalk neutralises vinegar, &c, &c. But enough of these guesses and hap-hazards. Forsooth, they represent a child, the temporary arbiter of a chess-board, who pushes first one piece forward, then a second, a third, and so on, without judgment, the least foresight, or anticipation of consequences ; in fact, plays a regular chance-medley. One advocates homoeopathy — another allopathy — another hydropathy — another mesmerism, &c, &c, until the patient becomes confused and discovers medicine to be truly an uncertain art. It is these strange contradictions, these unfortunate 6 dissensions, that destroy the necessary confidence in the disciples of . The ¦ ' doctor" of the past generation held up his gold-headed cane to his nose, inflated his cheeks, spoke, and was estimated a prophet, while the present Galen is watched suspiciously, as unnecessarily filling the " corpus" with his wares ; the amount of his knowledge is discussed and his opinions disputed. Although the awful visitant, Cholera, is evidently a scourge of the great just God, we should not idly despair, for through His mercy we are still allowed the use of means, if applied through the laws of cause and effect, and which, though imperfectly understood, will, we hope, save thousands during the next few months the dreadful Epidemic probably will remain with us. Having had for several years an expectation of its intended visit, we have, therefore, studied the complaint from all available sources, and are convinced that the stimulant treatment alone, as commonly pursued, arising from a mistaken notion that to subdue the symptoms is to cure the disease, is ineffective, dangerous, and decidedly bad. It is now three years sinee — some time before the Cholera had arisen in Persia, or hung its death-pall over the Russian River Neva — that we foretold its appearance sooner or later in our own country. And why ? For the very simple reason that according to the custom of severe Epidemics, as told us by all history, it had sent its heralds in advance. A vegetable blight— a potato Cholera, had come amongst us. Two years ago we again heard the signal of its advent. The animal Cholera, or Smallpox as we called it, then raged amongst sheep and other animals, and carried off its thousands ; and 7 now, after the last warning, the Influenza of the bygone year has been given the more complex organisatio — Man, the animal with an immortal mind, has become susceptible to this direful disorder. • Yes ; the Cholera is, indeed, here. That disease whose attributes are mystery and death — that appalling and terrific Influence which has for centuries been stifling its thousands in domestic privacy amidst the swamps of the Ganges and the jungles of Bengal, has been aroused from its accustomed locale, and from some inexplicable, unexplainable cause, is now careering through, and pursuing its fated victims to, remote parts of the world, leaving in its desolated path the plague-marked bodies of tens of thousands which it has slain. Indeed, there is something truly awful in its erratic and capricious visits, for whilst the inhabitants of one city are listening with thrilling interest and pity to the bulletin of its life-destroying breath in a distant town, and feeling thankful for their own immunity, the mysterious Horror suddenly appears among themselve — attacks and slays. The cause of the Epidemic has never been satisfactorily explained, and according to our present slow progress of scientific research to the present generation, probably never will be. It would be useless to enter here into a controversial discussion that should extend to volumes, but briefly to notice that some persons imagine it to be malaria in the air, or a poisoned atmosphere ; some infer it is telluric, and the awful accompaniment of magnetic variations, volcanic changes, and destroying earthquakes. A skilful electrician tells us to look at electricity as the cause, points to the Cholera cloud, quotes the negative state of the air during the prevalence 8 of the disease, and refers us to induction as the occasion of attack and the sudden prostration of all the animal powers which ensues. Thus, though there be these differences of opinion, electricity, we think, by its known vagaries and universal domination can be made accountable by ity decomposing powers, and the changes arising in things from its positive and negative condition in them ; for the liberation of malarise, atmospheric deficiencies, and volcanic influences, although, from our present ignorance and inability to separate cause from effect, we can easily fall into laughable errors, somewhat similar to a worthy gentleman who, engaged in philosophic investigation some years ago, putting on his microscopic eye-glasses became suddenly breathless upon discovering some tiny insects crawling on some blighted potato haulm, which he immediately classed "Aphis vastator," the fearful cause of " Irish famine and English beggary," totally forgetting, poor man, that animalculse is the immediate effect of electrical^decompositions and aberrations, and that he, sleepy one, was safe in bed when at midnight the negative wind had done its destructive work. And here we would wish the probability to be understood that the Cholera Morbus, though not animalcular in its origin, yet the momentary electrical deficiency, or negative condition of the brain, affecting the whole body — that is, when the sudden faintness or deathy sensation occurs, which most patients have felt when attacked, though it may have been two or three days before the severe symptoms have begun — may give birth to animalcules or the fomiies, which eventually produce the horrible sequelae. Thus the negative stroke, if we 9 may use the expression, destroys life as well as the positive lightning flash. The scientific man will easily recollect the experiments of a clever electrician for producing insects though the agency of electrical decompositions, and will analogise his inferences. DIFFERENT SPECIES. It appears to be a general question whether the foreign and the English Choleras are fundamentally distinct, or constitute one and the same disease, differing only in the intensity of their effects. Some physicians believe that they are the same disorder, and others to the contrary. However, the membrane that lines the stomach and intestines seems to be the seat of disease in both (notwithstanding the cerebral nerves might originally have been the defaulters), and, though the discharge of bile in the English type may give it a different character, yet the severe Asiatic Cholera may so completely close with its cramping power the ductus communis choledochus as to cause the absence of that peculiar fluid, and produce in lieu the chyly ricey stools. But, if we admit the electrical theory, the similarity can be easily imagined ; the vitiated air can be more so ; electrical defalcations can be greater and more extensive to produce the more speedy and severe effect, as takes place in the worse forDi. Consider the unhealthy atmosphere in autumn, when the English Cholera mostly prevails ; how many times the electrometer speaks of electrical deficiency when the nervous power in animals and vegetation in consequence, become so weak, that the leaf which has successfully resisted severe gales in 10 summer, now falls off green with a gentle breeze ; and the man who could eat cherries in large quantities at Midsummer, now falls a victim to a few plumbs. And yet it is not that the latter fruit is more unwholesome, but that the " nervous power" to digest it is diminished. This rationally explains why raw fruits and vegetables are improper to be eaten during the prevalence of Cholera, when the air is always in the negative state. Debilitated invalids deeply feel the electrical depression, and paralytics, though not scientifically, are personally painfully conscious of the whole affair. Thus, we opine, that whatever technical differences may be arranged by savans, in both disorders there evidently is an electrical robbery, affecting primarily the cerebral power, and producing, by its temporary paralysis, secondly, the diseased condition of the mucus surface of the stomach and alimentary canal, which, thirdly, obstructing the absorbents, closing the emunctories, intercepting all communication with the circulation, cause the congestive state of the different organs, the derangement of their functions, and the sad finale. Quite dissimilar to this are the typhus and scarlet fevers, small-pox, &c, in which the mucus membrane, from some undiscovered malarial poison, is the first to suffer, but which subsequently involves the whole nervous system. CONTAGION. Like everything else that is connected with this fatal malady, this consideration is enveloped in doubt. For if we are to value the latest statement of the Metropolitan Sanatory Commission, that 11 11 there is no evidence that Cholera spreads by communication of the infected with the healthy," we must disbelieve well authenticated instances of its contagious character recorded in some Medical Officer's " East Indian Experiences, analagous cases in this country, and the Remarks of an eminent Chemist who saw much of the Cholera of 1832," that infection can be conveyed by articles of clothing, bedding, &c. Now, without citing cases pro and con, which are almost endless, very confusing, and are still inconclusive, nor wishing to create unnecessary alarm, it should nevertheless be strongly inculcated that all evacuations should be immediately removed, and all soiled linen well washed, for we do know that there are effluvia and foul exhalations arising from all diseased excrements, which are decidedly dangerous, and from the effects of which the anomalous cases of which we read have perhaps occurred. For the sake of humanity, let us here observe that it is most desirable that some means should be suggested to ascertain, for a certainty, when the vital principle has become extinct in the diseased body, for the deathlike appearance of collapse, the fear and flurry of attendants, the hurried interment, all favour what nature most shrinks from — the premature return to our mother earth. TREATMENT. Of all perplexing and difficult things, the proper treatment of Cholera appears the least understood, and this partially arises from the entire ignorance of the origin of the disease, and also from the hitherto unsatisfactory inferences, from its pathological investigation. 12 One of the Faculty tells us, to place full confidence in a recipe composed of stimulating aromatic oils, which sixteen years ago were of no avail. Another asserts the powerful saving effects of calomel and opium, which the great experience of medical men in India presents but as a sorry resource. Also an Arabian manuscript is found, hieroglyphiced with a never-failing remedy, composed of pepper, opium, and assafcetida, which has been copied into the newspapers and circulated. And then every medicinal, possessed of remedial virtue, is prescribed, according to the passing opinion, so that instead of being the most difficult, with such a multiplicity of remedies we might imagine it to be a disorder most easily cured. The following are some of the medicines commonly advised : — Arsenic, Strychnine, Olive Oil, Opium, Castor Oil, Calomel, Mustard, Sweet Nitre, Naphtha, Magnesia, Prussic Acid, Carbonate Soda, Table Salt, Sulphate of Quinine, Charcoal, Musk, Mint Tea, Sulphate of Iron, Ipecacuanha, Ammonia, iEther, Cayenne Pepper, Cajeput Oil, Khubarb, And other drugs, together with bleeding, spirit, vapour, and medicated baths, cold affusion, &c, &c. Yet, after the disappearance of the Cholera, in 1833, one of our most eminent Physicians said it was his full conviction, that if no medicine had been given, no sanatory effort made, no consultation held, and all the Cholera patients had been left to Nature's 13 reactionary struggles, in their beds, as many would have recovered as did recover, and as many would have died as did die. And now the Cholera has revisited us, the same treatment apparently is going to be renewed, and it is to be expected reasonably with the same lamentable results. The reason of this almost constant catastrophe to remedial- efforts, resulted, we think, from the erroneous ideas entertained relative to the disorder, for the symptoms appear to have been mistaken for the disease, instead of their having been recognised as an evidence of its presence. Some medical men wanted by the aid of calomel to stimulate the liver, and bring it into secreting action — because they saw no bile. Others wished by diaphoretics to produce cutaneous secretion — because there was no perspiration. Some tried diuretics — because the kidneys and bladder would not act — and so on. But all were failures, and why ? Because the cause had not been removed, which had provoked them to cease their functions and paralyzed their healthy power ; because the miasmatic poison which had spasmed their outlets had not been destroyed, and which had prevented them continuing the duties they had performed for years. No ; first chemically destroy in cholera the morbid virus of the stomach and intestines (which is produced probably by the temporary paralyzation of the par vagum, the pneumogastric nerves), which ultimately vitiates all the fluids and deranges all the organs of the human system— purify the mucus membrane of the stomach and primse vise restoring it to its former healthy state and action, so that the lacteals can once more imbibe chyle, the bile duct be re-opened and the colon depurate — the liver will 14 then secrete without calomel — the skin by the vis c tergo of its capillaries will exhale, and the kidneys and bladder, re-act. But why are we so certain that this is so? Because post mortem examinations clearly evidences it. It is universally agreed that no unhealthy appearances have been found in the serous membranes, and the cavities they line. The liver, heart, and lungs, are congested, of course ; but on the mucus surface of the duo-* denum and jejunum we can find the filthy and dirty coloured venom — in the often gangrenous ilium and contracted colon, we can easily trace, the evil that caused the paralyzation of the lacteals, the spasmodic closing of the biliary duct, and detect the destructive power, that neither calomel, opium, pepper, brandy, nor any spirituous stimulating medicament could touch or even possibly benefit. Now, whatever is the cause of Cholera, that which is of the greatest importance to us is to endeavour by scientific aid to destroy its virulent effects on our bodies. The great God has so wondrously circled our animal system, that to human investigation it is most baffling to discover, most difficult to decide, which organ was first affected, which commenced the dereliction from its normal action — whether the injured brain by the disabled pneumogastric nerves effected the diseased state of the stomach and intestines, or malarious animalculse attacking the stomach affected subsequently the brain, the great nervous centre. Possibly the former would produce Cholera Asphyxia, with the consequent difficulty of breathing, and the latter Cholera Mitior with its attendant Typhoid Fever. However, without discussing further the cause of symptoms, we will endeavour from a few known 15 diagnostics to indicate a remedy. Thus : great langour and depression of nervous power ; a deficiency of carbonic acid gas in respiration ; the dark venousblood appearance of arterial blood ; the coldness of breath in respiration ; the peculiar appearance of the mucus membrane of the intestines ; with the closed lacteals and turgid vessels of the mesentery ; the nature of the vomit and fseces. ? Now these facts exhibit three great defalcations, or deficiencies, in the system, which require as a corresponding aid : Ist, a supply of oxygen ; 2ndly, electrical assistance ; 3rdly, an antidote to the virus (engendered on the mucus membrane, and produced by the loss of the two former). The great desideratum, then, is first to disinfect and destroy the deadly mucus, which lies like an incubus on the surface of the intestinal tube, whose peristaltic struggles are mostly ineffective to remove it. Secondly, it is necessary to introduce oxygen into the circulation ; and, thirdly, electrical stimulus should be given to the system. The difficulty here to be overcome, results from the great want of nervous or electrical action in the system, to promote the decomposition and absorption of the remedies ; for if the blood could be oxygenised, the almost paralysed respiratory organs would again be enabled to decompose the air, which would again produce the necessary animal heat by uniting its constituents with the highly carbonised blood, which would once more flow a healthy oxygenised stream, to stimulate to muscular contractions the almost paralysed heart, which would again pump forth the vital stream to repair all functional injuries. No wonder then that there is no nervous power 16 if there be no electrical decomposition in the stomach and lungs ; no surprise then that there is no animal heat, the breath is cold in respiration, and a deficiency exists of carbonic acid gas ; if oxygen cannot be supplied in sufficient quantity by the feeble respiratory apparatus to colour the effete venous blood — Oxygen, the stimulant principle of the blood, must then be the remedy, the requisite for that vital fluid. But how can we introduce it into the human system — surely not by brandy and other spirit's ? Those hydrocarbonated liquids do not decompose and yield oxygen, neither does ammonia, nor calomel, or any of that class of stimulants. But it must be with materiel that contain oxygen, as Acids, easily decomposable Acids ; which are well known to furnish this valuable gas to the blood, thus performing in part the duty of the weakened lungs — -generate electricity — prove powerful disinfectant — and relieve congestion, as relaxants, while they will increase secretion. Acids were found to be the best antidote for the plague, have proved the finest remedy for typhus and other malarial fevers, and are the most sure destroyer of animalculae, generated by miasmatae. The keen observer may have noticed the strange speckled appearance of the brown-furred tongue in Cholera Mitior, in contradistinction to its white surface in Cholera Asphyxia, and which the microscope might probably reveal as formations from animalcular deposits. As in this terrible malady the least delay is a sentence of death, the stomach should not be considered the only absorbing surface for our remedies ; sponges wetted with hot vinegar should be placed to the axillae (armpits), and all the superficial absorbents 17 of the wrist, neck, tMghs, elbows, knees, should if possible be brought into action, by friction with flannel moistened with the hot acid. In accordance with these views, that highly successful medicine, Fennings' Cholera Mixture has been prepared, and from the cures it has effected, and its invariable efficacy when taken in time, claims a confidence which no other medicine can do with justice. The following symptoms of attack are extracted from a clever work by Dr. G. B. Thorn, on Cholera : — " The patient feels, for some hours before, a, sense of lamgour which affects the system in a greater or less degree, according to circumstances, accompanied with oppression, anxiety, and heat in the epigastrium — symptoms which increase with greater or less rapidity, the anxiety and langour being especially manifested, so much so that the lineaments of the countenance give to it a certain marked expression of anguish. The pulse is, for the most part, quick and oppressed. The evacuations consist, at first, of substances proceeding from a disordered state of the stomach and the intestines, and are so copious that the whole intestinal tube would seem to be affected. Although the spasms extend, as it were, all over the body, they are violent only at the extremities. With the commencement of the spasms and repeated evacuations from the abdomen are found as accompaniments, loss of hearing, vertigo, buzzittg in the ears, and coldness at the extremities, as Well as throughout the whoje frame. The vomiting and evacuations become more frequent, and a liquid similar to rice water is discharged. The disorder progresses — complete prostration, 16 if there be no electrical decomposition in the stomach and lungs ; no surprise then that there is no animal heat, the breath is cold in respiration, and a deficiency exists of carbonic acid gas ; if oxygen cannot be supplied in sufficient quantity by the feeble respiratory apparatus to colour the effete venous blood — Oxygen, the stimulant principle of the blood, must then be the remedy, the requisite for that vital fluid. But how can we introduce it into the human system— surely not by brandy and other spirit's ? Those hydrocarbonated liquids do not decompose and yield oxygen, neither does ammonia, nor calomel, or any of that class of stimulants. But it must be with materiel that contain oxygen, as Acids, easily decomposable Acids ; which are well known to furnish this valuable gas to the blood, thus performing in part the duty of the weakened lungs — -generate electricity— prove powerful disinfectants—and relieve congestion, as relaxants, while they will increase secretion. Acids were found to be the best antidote for the plague, have proved the finest remedy for typhus and other malarial fevers, and are the most sure destroyer of animalculae, generated by miasmatse. The keen observer may have noticed the strange speckled appearance of the brown-furred tongue in Cholera Mitior, in contradistinction to its white surface in Cholera Asphyxia, and which the microscope might probably reveal as formations from animalcular deposits. As in this terrible malady the least delay is a sentence of death, the stomach should not be considered the only absorbing surface for our remedies ; sponges wetted with hot vinegar should be placed to the axillae (armpits), and all the superficial ab- 17 sorbents of the wrist, neck, thighs, elbows, knees, should if possible be brought into action, by friction with flannel moistened with the hot acid. In accordance with these views, that highly successful medicine, Fennings* Cholera Mixture has been prepared, and from the cures it has effected, and its invariable efficacy when taken in time, claims a confidence which no other medicine can do with justice. The following symptoms of attack are extracted from a clever work by Dr. G. B. Thorn, on Cholera : — " The patient feels, for some hours before, & sense of langour which affects the system in a greater or less degree, according to circumstances, accompanied with oppression, anxiety, and heat in the epigastrium — symptoms which increase with greater or less rapidity, the anxiety and langour being especially manifested, so much so that the lineaments of the countenance give to it a certain marked expression of anguish. The pulse is, for the most part, quick and oppressed. The evacuations consist, at first, of substances proceeding from a disordered state of the stomach and the intestines, and are so copious that the whole intestinal tube would seem to be affected. Although the spasms extend, as it were, all over the body, they are violent only at the extremities. With the commencement of the spasms and repeated evacuations from the abdomen are found as accompaniments, loss of hearing, vertigo, bu2zkig in the ears, and coldness at the extremities, as well as throughout the whoje frame. The vomiting and evacuations become more frequent, and a liquid similar to rice water is discharged. The disorder progresses— complete prostration, 18 variation of the voice, and all the other fearful characteristic symptoms close the scene, if unchecked, in a few hours. (Copy of a Letter. J TO THE PRESIDENT OF THE GENERAL BOARD OF HEALTH. Oct. 23, 1848. Sir — The Cholera having arrived in England prompts me to this communication, well knowing that any chance of subduing the terrible visitant will not be slighted by you. Having been uniformly successful with a mixture in hundreds of cases, for several years, in severe English Cholera, with symptoms partaking of the Asiatic type — viz., nearly stagnated circulation, evinced by the blue tinge of the lips and finger nails, spasmodic cramps, chyle stools, insatiable thirst, with almost incessant vomiting, makes me most anxious to have the honour of an interview, in order that a trial may be immediately made in any fresh Cholera cases of its great value. Although, Sir, it is for the present a private emolument, yet upon your being convinced of its efficacy as the best antidote, and consequently giving it official recommendation, for the sake of humanity I will immediately make it public, with trust that by so doing the Government will not allow me to suffer any loss. An early answer will oblige Your obedient servant, &c, &c. London : Printed by G. Peirce, 310, Strand. FENNfNGS* STOMACHIC MIXTURE, ?he celebrated Remedy against t%e infection of .Cholera, for Low Spirits, Nervous feelings, Bile, Faintings, Jjotee} Coriwlaints, Looseness, Griping Pains, Sore Throats, Cramps, Tf\ndy Spasms, English Qholera, Sfc. This valuable pleasant -tasted Medicine, to which thousands Owe their lives, and permanently have derived the greatest benefit, often cures with one dose. A bottle of "FENNINGS' STOMACHIC MIXTURE," should be kept READY for use in all HOUSES, because— First— The Cholera ra.ost frequently attacks at midnight. Secondly— An attack often commences with a slight looseness of the Bowels, which the "Mixture" immediately stops. Thirdly — If contagious diseases are in the neighbourhood or house, it should immediately be taken as a preventative. Fourthly-— The Infection often remains hidden in the System for two or three days, a dose will then prevent the disease breaking out by destroying the Infectious Poison. Fifthly— lt is the only efficacious medicine known for Cholera* Opium, Calomel, and Tonics once recoipmended, from experience are found to be useless and inefficient, and the " Stimulant Oils " used in 1832 were a total failure. Sixthly — It should be kept ready for immediate use, because, in this awful disease, the first b,Qur lqst, is often the only chance of Life thrown away. Seventhly— The Penalty of not having the medicine in the House ready to take at a critical moment might be DEATH. A dose taken twice or three times a week will prevent persons catching the Malignant Cholera, if in the neighbourhood or house. S*old in Bottles, with Government Stamp, and full Directions, 2s. 9d. and 4s. 6d. ; large size for families (great saving), Bs. each. By Appointment, at the GOLDEN KEY, BROADWAY* HAMMERSMITH. On receipt of a Letter, enclosing an Order and Remittance, addressed FENNINGS', Broadway, Hammersmith, the " Mixture" will be immediately sent to any part of the United Kingdom. For charitable purposes, or in quantity, a great allowance is made. [FOR LIST OF AOKNW, SBR NKXT PAM. ->. FENNINGS' STOMACHIC MIXTURE. WHOLESALE AGENTS. Barclay and Sons, Farringdon-street ; Edwards, St. Paul's Churchyard ; Sutton, Bow Churchyard ; Sanger, 150, Oxfordstreet ; Johnson, 68, Cornhill ; Prout, 229, Strand ; Haimay and Dietrichsen, Oxford-street ; Prentis, 84a, Edgware-road; also by Collins, 54, Piccadilly ; Kingsford, Kensington ; Rouse, Clapham ; Freeman, 13, Blackfriars-road ; Tuck, Mile-end-road; Harding and Clarke, Richmond ; "Watts, Hampstead ; Richards, Camberwell ; Faulconer and Steedinan, Walwdfth ; Watts, 106, Edgware-road; Waugh, Camden-town ; Kelland, Greenwich; Gosd, 47, Minories ; Allans, 60, Powis-street, Woolwich; Bidwell, 1, Uftion-terrace, Notting-hill ; Bicknell, 38, Ebury-street, Pimlico ; Collins, Islington-green; Kain, 5, York-terrace, Commercial-road; Bossy, Brunswick-place, Stoke Newington ; Lloyd, Post-office, Richmond ; Gosling, 3, Grays-place, Brompton; Lucas, 63, Cheapside; Crafton, High-street, Croydon, &c. OOUNTEY AGENTS. Birmingham, Banks, 3, High-street ; Hertford, F. Wheeler, St. Ms ; Worcester, Lea and Perrins, Chemists ; Northumberland, Daglish and Ismay, Newcastle-on-Tyne ; Leeds, Reinhardts and Sons, 76, Briggate ; Norwich, H. Thompson, St. Stephens-street; Gloucester, Edward Coleman, Chemist; Lancashire, J. Raw, Pres- ton; Southampton, W. H. Steere, 26, Above Bar; Chatham, Tribe, Chemist, 137, High-street; Cambridge, W. H. S.mith, Chemist, Crescent ; Wiltshire, James Read, Devizes ; Lincoln, James Drury, 224, Stone-row; Oxford, Ohaundy, Chemist ; Hull, Noble, Marketplace ; Essex, J. Eagle, Chemist, Chelmsford ; Ramsgate, C. Fisher, High-street ; Stojvmarket, Thomas Simpson, Chemist ; Abingdon, W. Smith, High-street ; Yarmouth, F. Barnard, Broad-row ; Margate, F. Kinch, High-street ; Romford, J. Thurlby, High-street ; Sussex, W. Mason, High-street, Hastings; Hereford, F. and A. Merrick, High-street ; Chichester, J. W. Buckell, Chemist ; Devflnport, Byers, Fore-street ; Dover, J. S. Neales, Chemist ; St. Neots, W. T. Mble, Druggist; York, C. Crosskell, The Pavement; Lancaster, Edward Wilson, Chemist ; Watford, J. Chater, Highstreet; Faversham, T. BusB, Market-place; Ashford, J. Farmer, High-stroet ; Coventry, Binley, Chemist ; Horncastle, W. P. Carlton, Higu-street ; Cirencester, J. W. Mason, Chemist ; Lewes, T. Figg, High-street, Cliffe ; Bradford, Maud and Wilson, Sun Bridge ; Kingston, Gould, Market-place; and by all respectable Chemists