NATIONAL LIBRARY OF MEDICINE NLfl 0D1035AQ D national library of medicine national library of medicine national library of medicine t JNmasw jo Aavaan tvnoiivn snidicbw jo Aavaan ivnoiivn jnidiqsw jo Aavaan ivnoiivn 3 national library of medicine national library of medicine national library of MEDICINE is ■'jry 3Nma3w jo Aavaan tvnoiivn snidicisw jo Aavaan tvnoiivn SNiDiasw jo Aavaan tvnoiivn 31 / l NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE N 3NIDI03W JO AilVJian TVNOIIVN 3NIDI03W JO Aava8IT TVNOIIVN 3NI3I03W JO AaVaBIT IVNOIIVN 31 NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE N 3NIDIQ3W jo Aavaan tvnoiivn snidiqsw jo Aavaan tvnoiivn snidiqsw jo Aavaan tvnoiivn 3f * Si. / - C ASK * <££*. X 1 < A2R £ -a NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NLM001035800 **v. jo Aavaan tvnoiivn 3NiDia3w jo Aavaan ivnoiivn u 3NiDia3w jo Aavaan ivnoiivn LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE jo Aavaan tvnoiivn snidiosw jo Aavaan tvnoiivn SNioiaaw jo Aavaan ivnoiivn .IBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE X. "2 jo Aavaan tvnoiivn snidiosw jo Aavaan tvnoiivn 3nidici3w jo Aavaan tvnoiivn IBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE IBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE "o S 1 jo Aavaan tvnoiivn 3nioici3w jo Aavaan tvnoiivn snoiosw jo Aavaan tvnoiivn LIBRARY OF MEDICINE NATIONAL LIBRARY OF MEDICINE ^^ 1 ^aE-x I A ,3> A Pathogenetic Materia Medica. BY THE MEDICAL INVESTIGATION CLUB OF BALTIMORE, MD. A Pathogenetic Materia Medica, BASED UPON DRS. HUGHES' AND DAKE'S CYCLOPAE- DIA OF DRUG PATHOGENESY. BY The Medical Investigation Club OF BALTIMORE, AID. MEMBERS, honorary: ELIAS C. PRICE, M. D., Prof. Institutes and Hygiene, Southern Homoeo- pathic Medical College. active: ELDRIDGE C. PRICE, M. D., Prof. Materia Medica and Therapeutics, Southern Homoeopathic Medical College. ROBERT W. MIFFLIN. M. D., Prof. Pathology and Practice of Medicine, Southern Homoeopathic Medical College. O. EDWARD JANNEY, M. D., Prof. Paedology and Orthopaedic Surgery, 5 Southern Homoeopathic Medical College. GEORGE T. SHOWER, M. D., Assoc. Prof. Physiology, and Lecturer on Pharmacy and Toxicology, Southern Homoeopathic Medical College. ) HENRY CHANDLEE, M. D., Prof. Obstetrics, Southern Homoeopathic P Medical College. PHILADELPHIA: BOERICKE & TAFEL, 1895. ,<•■■• ■•;■ ? 1 ^ °" Spijis \l0lur9e is Respectfully QeeLicetleel, irj ^ppreciettiorj of ^b®" ^ife ^°^ "^ Rruitful LSeiWs ir) ^Wteriei ■ yicaicer. ERRATA. Page xv of Introduction, fourteenth line from bottom: for " Pathogenetic," read " Pathogenetic." Page 31, ninth line from bottom: for " inflammatian," read " inflammation." Page 32, first line: for "fauciua," read "faucium." Page 45, under "Ears," the semicolon following tinnitus aurium should be a colon. Page 51, foot-note, fourth line from top: second "pain" should be "pains." Page 52, second line under "Stomach:" "giddiness" should be followed by the exponent 2. Page 57, under "Abdomen," second line: the semicolon fol- lowing "region," should be a colon. Page 107, twelfth line from bottom: for "nephrites," read "nephritis." Page 132, line next to bottom: for "in," read "is." Page 148, sixth line from bottom: for "estacy," read "ecstacy." Page 199, under "Therapeutic Application," seventh line from top of paragraph: for "all," read "many of." Page 245, the symptom under "Amelioration" should be followed by the exponent 2. Page 261, under "Therapeutic Application," second line from top of paragraph: for "organs," read "centres." PREFACE. On Saturday, November 5th, 1881, the Medical Investiga- tion Club of Baltimore, Maryland, was organized. The origi- nal members were Elias C. Price, M. D., R. W. Mifflin, M. D., William B. Turner, M. D., J. A. Gwaltney, M. D. (since deceased), and Eldridge C. Price, M. D. To this list of mem- bership more latterly was added the names of O. Edward Jan- ney, M. D., Henry Chandlee, M. D., George T. Shower, M. D., A. H. Barrett, M. D., F. B. Mickle, M. D. (since deceased), and Charles H. Young, M. D. Owing to death and removal from Baltimore, the Club membership has been reduced, and for a number of years but six men have composed the organization, one of whom is now an honorary member. At its inception the object of the Investigation Club was to do original work in the various fields of medicine, but during the winter of 1886 and 1887, it was decided to limit the work to a study of materia medica. As a result, the present plan of work was adopted, without the intention of publishing the results, however, but simply for the purpose of individual im- provement. As the work progressed and its importance dawned upon the Club, it was decided to give the benefit of the researches in pathogenesy to the medical world, and hence a number of studies were published in monthly periodicals, the Hahnemannian Monthly and the Southern Journal of Homoeop- athy being chosen for that purpose. These specimens of our work met with so warm a welcome from the profession that we determined upon publishing our efforts in book form. It is to be regretted that a greater number of drugs could not have been presented in this volume, but with the many other important duties of the individual members of the Club, it was impossible at present to undertake the arduous task of constructing additional syntheses. Unless one has undertaken to do work of this character, it is impossible to conceive of the viii PREFACE. enormous labor and great amount of time necessarily expended in the details. This book has been printed to correspond in size with the Cyclopcedia of Drug Pathogenesy, and may be used as a reper- tory of some of the most important and best proved drugs in that work, i. e., of a number of those drugs which have been tested by not less than ten experimenters. Objection may be raised to the few drugs herein contained, and disappointment may be felt at the meagreness of some of the symptomatologies, but for neither of these important facts are we responsible; the burden rests upon those who have undertaken to give records of drug effects. These difficulties dimly show the need of a thorough and scientific reproving of the materia medica. The records from which the various symptomatologies have been drawn are taken largely from the Cyclopcedia of Drug Pathogenesy, Dr. Allen's Encyclopcedia of Pure Materia Medica, Metcalfs Provings, the Transactions of the American Institute of 'Homoeopathy', the autograph records of provings of gelsemium as found in the bound theses in the library of the Hahnemann Medical College of Philadelphia, etc. To all authors and sources from which the material for this work has been derived, we here express our obligations. The work is by no means complete; it includes but forty- seven drugs, but this is sufficient to make a respectable nucleus for an exhaustive, pure pathogenetic symptomatology of the future. Of course we are aware of the many deficiencies in our work —none others more fully—but having accomplished our task as thoroughly as time and facilities have permitted, we submit this effort to the tender mercies of our medical brethren, and with the honest wish that they may derive as much pleasure and profit from its study as have its authors from its con- struction. ELDRIDGE C. PRICE, ROBERT \V. MIFFLIN, O. EDWARD JANNEY, GEORGE T. SHOWER, HENRY CHANDLEE. Baltimore, Md., June 14, 1894. INTRODUCTION. In the early days of this age of books the very fact of the dearth of literature was sufficient excuse for the appearance of a book,even though it were a very poor book. This demand for books has finally created such an inexhaustible supply that the ever-modest author has found it necessary to apologize for obtruding his efforts upon the literary public. Not only is this overcrowded state of the secular book market true, but it is also the case in medical literature, and particularly in the department of homoeopathic materia medica. In submitting to the profession the results of these labors of the Investigation Club, as an excuse, explanation, or what you please, is offered the conviction that this compilation fills a place occupied by no other work, that it^is needed, and that it is in accordance with the requirements of science. It is unnecessary to note the various stages through which this work has passed; suffice it to say that early in the spring of 1888 the Medical Investigation Club was fully engaged in working upon the synthetic method. The plan adopted divides the study of drugs into two depart- ments: first, history; and second, symtomatology or patho- genesy. While the Club has engaged in a study of the history of individual drugs, yet it has been deemed wise at the present time to publish the pathogenetic and therapeutic investigations only, reserving for the future the possible publication of the historical researches. The pathogenetic department, which is alone here con- sidered, is arranged in several sub-departments: 1st. Introductory remarks relative to the records used and the records unused. 2d. The general sphere of action of the drug, drawn from poisonings and provings, with suggestions taken from experi- ments upon animals. x INTRODUCTION. 3d. The composite symptomatology or synthesis of patho- genetic effects. 4th. The application of the symptomatology to therapeutics. In the general sphere of action of the drugs treated in this volume, it would have been a pleasant task to map out a regu- lar and unvarying sequential order in which the various organs and tissues are affected, and to elaborate the details into novel- istic interest; but an unvarying sequence of drug effects does not exist, and having pledged ourselves to give plain facts only, the results obtained may sometimes be disappointing, but they are at least as accurate as the obtainable records permit. In the therapeutic department of each drug an effort has been made to adhere closely to the symptomatology of the drug, and the only departures have been made in the inferences drawn from the general sphere of action. This department is by no means full and complete, but is merely suggestive, and we trust to the future for many more additions. The method of studying pathogenesy, upon which this work is based, is inductive, in that the symptomatology is drawn from the detailed symptoms of individual provers, and con- densed as far as scientifically consistent into generalized patho- genesy ; it is eliminative to the extent of omitting single symp- toms to await future corroboration; it is analytical in that the provers' records are critically examined, and in so far as possi- ble only bona fide drug symptoms retained; and it is syntheti- cal in its reduction of the many symptoms variously worded, but having the same meaning, to a single form expressing the sense of the whole. Two words cover the whole method, analysis and synthesis. According to the usually accepted dictionary meaning of these terms they are antipodal and can not be reconciled in any particular; but when we study their relation a little more closely we realize the fact that the processes expressed by the words are interdependent, and each only exists because of the other. For the purpose of analysis we can not begin with ultimate elements, but there must be a something to take apart, "to unloose, to dissolve, to resolve into its elements," as INTRODUCTION. XI Webster expresses it; and to synthetize there must be some- thing separated so that it can be put together; therefore, analysis depends upon synthesis and synthesis depends upon analysis, and although they are antagonistic, each exists be- cause of the other. This plan of study is both disintegrative and aggregative, there is first separation and then combination. For the first time in the construction of detailed pathogenesy in the schematic symptomatology of the books, symptoms are an- alyzed and then synthetized. Sir William Hamilton says: "Analysis and synthesis, though commonly treated as two different methods, are, if properly understood, only two neces- sary parts of the same method. Each is the relative and correlative of the other." The details sustain the claim that the application of this plan to a reconstruction of drug effects, results in the production of a synthetic symptomatology. The third sub-department, the symptomatology, demands a detailed explanation. A drug is selected for study; all the provings of this drug are carefully read, and each symptom of the whole collection is transcribed to its proper division in the Hahnemannian schema (which has been adopted), e. g., all the mind symptoms found in all the records are grouped together, likewise the head symptoms, the eye symptoms, et seq., to the end of the schema. Thus the whole collection of records is transcribed in a rearranged form and is ready for analysis. Each group of symptoms is now carefully scanned and an- other transcription is made. This contains all the symptoms that have been experienced by two or more provers. Of course the more provers that are similarly affected the more valuable are the symptoms they experience; therefore, to indicate its value we have affixed to each symptom the figure corresponding to the number of provers who have experienced it. This renders it necessary to condense the various expres- sions of one idea, which have been used by the different re- corders, into one phrase which will not do violence to the meaning of any prover, and yet give full significance to the symptom. Thus in bryonia we find the following ear symp- Xll INTRODUCTION. toms, as expressed by five distinct provers: "Whizzing in ears. Ringing in ears." "Singing in ears. Whizzing in ears." "Hissing in left ear." "Humming in ears." "Noise in left ear as of water pouring over a dam. Roaring noise in right ear." Observe that of these five provers but two give expres- sion to their sensations in the same phraseology; to these, of course, credit is given in their own words, while at the same time fitting expression must be used to sense the meaning of the whole five observers, and hence the condensation gives: "Noises in ears:5 whizzing in ears.2" Six words here give the idea, which, according to the old detailed manner of re- cording, demands the use of twenty-nine words. It is this composite method of expression which suggests the particular underlying state causing the symptom thus type- fied to which the term synthetic pathogenesis is due, and which is the salient point of the work of the Investigation Club. The higher the exponent attached to the symptom (granting the symptom to be consonant with the sphere of action of the drug), the greater will be one's confidence in that symptom. There are also some symptoms which have occurred in only two or three provers, which arc probably quite as trustworthy as those experienced by more provers; but the average high- exponent symptom is more valuable than the average low- exponent symptom, and quite probably a large number of the latter would have been omitted if health records had preceded the provings. Isolated symptoms, i. e., those appearing in one record only, are excluded. By this exclusion, however, the single symptom is not condemned as of no value, but it is omitted simply because it has no verification and may be a mere peculiarity of the individual. Future drug tests must decide the point. Early in this work the question of the proportion of provers to each symptom to be recorded in the composite symptoma- tology or synthesis, was discussed, and after canvassing the ad- visability of various percentages, the rule was finally adopted that only symptoms experienced by two or more provers should be recorded. Upon putting this rule to the test it was surpris- INTRODUCTION. Xlll ing how large a number of symptoms were left in the original proving-records awaiting future verification. (That is to say, it is surprising how many of the symptoms at present recorded in the works on materia medica are to be found in one proving only.) It also became obvious that if a much larger propor- tion of symptoms were excluded, the new plan of work would be more than iconoclastic, for it would not only demolish the ikon, but it would threaten the very foundation of our patho- genesy, the general sphere of drug action; and to deliberately do this would insure our mistrust of pathogenesy (and upon pathogenesy homoeopathy itself is based), simply because few other details would find place in the final symptomatology than those indicative of local gastric and bowel disturbance, reflex head symptoms, and a few others of a like nature. Especially is this true of the vegetable drugs. This would occur with disheartening persistence in nearly every drug. After an ex- perience gained from the reconstruction of the drugs in this volume, the Club feels assured that the decision was a wise one, and consequently, in the synthesis of drug effects, each symptom has an exponent, the figure corresponding with the number of provers who experienced the given symptom (as hereinbefore explained), and by comparing the exponent of each symptom with the total number of provers of the drug under considera- tion, its percentage value may be found. This allows the practitioner to judge of the pathogenetic weight of each indi- vidual symptom; nothing of value is omitted and he can use all the symptoms or he can reject all but those having high- value exponents. And now a word about punctuation in its relation to the arrangement of the symptoms. In the symptomatology of bryonia we find the following sentence: "Constipation9: with small4, hard motions5, and urging to stool4." The colon fol- lowing "constipation" indicates that the symptoms constitut- ing the balance of the sentence were experienced by the same provers having "constipation." The exponent figure always applies to that part of the sentence between it and the preced- xiv INTRODUCTION. ing figure; or, if there is no other figure in the sentence then the single exponent applies to the whole sentence. Not only have pathogenetic records proper been utilized, but poisoning cases have also been included, as there is no cogent or logical reason why symptoms resulting from poisonous doses of a drug should not be utilized in a synthetic study of prov- ings. The toxic cases are classed with the recognized provings because both are pathogenetic, the only difference is one of degree, it being impracticable to draw the line between a group of symptoms preceding death and a group of symptoms express- ing a condition that has just missed a fatal termination. An objection may be raised to this liberal method of study- ing drug effects by drawing attention to the fact that violent effects of crude drugs are gross symptoms, and by the attempt to differentiate such gross effects from the finer, dynamic symp- toms ; but it is only possible to draw an arbitrary line between these crude effects and the more subtle pathogenetic dis- turbances. In consequence, all results have been utilized which are believed to be pathogenetic, whether in mild or in fatal cases of drug effects, always, however, carefully excluding all ante mortem manifestations that are obviously due to rapidly approaching dissolution. Much has been written of late on the subject of primary and secondary effects of drugs. While the Club agrees with the so- called physiological school of medicine in acknowledging that. the differentiation of action and reaction of drugs is of great importance, and thinks that much would be gained, primarily to the science and secondarily to the art of medicine, by a thorough knowledge of the subject, yet, however desirable it may be to see this question settled, its ultimate solution is not within the province of this work. Therefore, the effects of drugs are given, as far as it has been possible to disentangle them from the personal idiosyncrasies of the different provers, and to the future must be left the privilege of determining which symptoms are purely primary and which are purely secondary. The synthetic method has never before been applied to the INTRODUCTION. XV study of materia medica, and it is believed that with the pre- liminary health-record its strict application in the future will produce a result more closely approximating a scientific materia medica than any that has yet been compiled. In fact, until a more scientific method is formulated, it is probable that the plan here adopted must determine the future status of homoeopathic materia medica. It is herein shown that far less is known of drug action, as founded upon the relation of pathogeny to pathology, than has heretofore been supposed. The work also discloses that a small proportion of prescriptions of homoeopathic practitioners (especially the pure symptomatologists), is based upon patho- genetic knowledge, and a large proportion is the result of clinical observations or of arbitrary inference. Simple clinicai facts verifying the curative power of. a drug may be as trustworthy as a priori pathogenetic information, but the difficulty is to prove them to be facts. Subjectivity, as placed by Dr. Beard in its relation to science, is accountable for more "verified clinical symptoms" than are the drugs to which the verifications are appended. As both clinical obser- vations and inference are subject to strong personal bias, and as only strict analysis and synthesis of pathogenesy result in correct knowledge of drug action the authors are convinced that in addition to its value as a text-book, this Pathogenetic Materia Medica will serve a useful end in calling to the atten- tion of the thinking and working medical world the facts that, first, we do not need new provings, but re-provings of old drugs; second, that with the little reliable pathogenetic material we have it is obvious that a large proportion of our prescriptions are purely empirical; third, that this latter fact should be recognized and corrected as far as possible by re- proving the old drugs and synthetizing their pathogeneses; fourth that this work of reconstruction should be undertaken and accomplished for the sake of the scientific status of homoeopathy, as well as for the practical good that may result from the application of a system of therapeutics based upon so strict a method. It may be well to add, however, that these XVI INTRODUCTION. investigations show that many of the symptoms which have been proven reliable in practice are really to be found in the pathogenetic records. It is to be hoped that the Women Physicians' Provers' Union, of the American Institute of Homoeopathy, will do some valuable work in this pathogenetic field. This collection of synthetic symptomatologies will be of value to the student at college as a means of teaching him positive effects of the drug unmixed with subjective imagin- ings, from which its sphere of action has been drawn, which in turn suggests to him its therapeutic application deduced from the pathogenesis. The endeavor of the most progressive members of the older school of medicine, of late years, has been to study what they term physiological drug effects. These physiological effects are none other than what may be more correctly called patho- genetic effects. Consequently, as this volume deals exclusively with pathogenetic drug effects, the attention of the student of the older theories of therapeutic application may be attracted to it, and as no other work exists in which pure and exclusive pathogenetic effects are placed in relation to homoeopathic therapeutics, it is to be hoped that this effort will initiate a desire among our brethren of the older school to drop all sectarian limitations, and with a determination to apply only the strict impartial tests of science to the analysis of homoeop- athy, make a critical study of the relation of pathogenesy to pathology. In setting forth the merits of work possessed by the syn- thetic method, it is not intended to give the impression that clinical observations are considered of no value; such an inten- tion is disclaimed. Dr. Farrington's Clinical Materia Medica, for example, is a valuable work and fills its place admirably, but a work on pure pathogenetic materia medica for the active practitioner is also necessary, and in the present advanced state of all branches of science and art, it is incumbent upon the medical profession to approximate as closel)- as possible correct knowledge in medicine, through which prescient therapeusis INTRODUCTION. xvii may accompany correct diagnosis. To this end it is necessary that drug action should be more thoroughly understood, and certainly this is only attainable by study of drug effects upon the healthy, and the reduction of the results of our observations to a synthesis expressive of the undoubted effects of the drug upon the whole group of experimenters as a composite type. In this way the general sphere of action is also discovered, and from it legitimate inference of details may be drawn that are not supplied by the given symptoms. Thus a prescriber may select a remedy with a degree of accuracy heretofore unknown if he will only appreciate the fact that although all the detailed symptoms the given drug is capable of curing, may not have been experienced by any of the provers, yet many symptoms may be taken as indications for a prescription, because they can be analogous only to symptoms which result from such disturbance in the human organism as is referable to the peculiar manner in which this given drug affects a tissue, an organ, or a set of organs. To this class of scientifically deduced indications we should wish to adhere as closely as practicable, leaving pure clinical experience in its proper department of clinical aids to therapeutics ; and using these aids always in the full knowledge that we are practicing empirically. To approximate this perfection, this prescience which is the highest attainment of science, it is not only necessary to prop- erly stud}' provings and formulate a reliable symptomatology therefrom, but it is primarily necessary, as already remarked, that each prover keep a record of the manifestations of his normal health status before testing the drug, for unless he is familiar with his condition prior to taking the drug, he is not prepared to pass judgment upon the pathogenetic value of the many manifestations that are likely to occur during the prov- ing. It is true that the exclusive synthetic method corrects to a certain extent the defects of the prevalent irregular modes of proving drugs; but for strict, scientific work, such only as the pathogenist of the future should do, the health record is indispensable. One of the flaws in the present unsystematized materia 2 xviii INTRODUCTION. medica (i. e., in our symptomatologies), is the dead-level value to which all symptoms are reduced. This is a serious defect, as it is the result of a false method, and prevents the student of materia medica from discovering the chief sphere of the drug's action; in consequence, unless an arbitrary gradation of the value of symptoms is formulated, the average novitiate in the art of medicine must conclude that the majority of drugs act in the same pathogenetic lines. This defect the Investigation Club has endeavored to overcome. An arrangement by which symptoms are given their true value is impossible, if it is made according to their equal frequency of occurrence in individual provers; simply because the same symptoms rarely occur with equal frequency in each experimenter. But when a symptom persistently occurs in a large number of provers, it naturally falls into its proper posi- tion of relative prominence in the schema. Thus the whole- sale reduction of symptoms to a dead-level is obviated by the very nature of the synthetic method. Another point to which attention is called, is, that with few exceptions Hahnemann's provings have been excluded from this work. This is not because they may not have value, but it is because sufficient details can not be obtained to prove this, as the records at command give neither dose, preparation of drug, nor other important points, and as this method of con- densation necessitates working from individual records, Hahne- mann's proving as now extant are not admissible. From experience in the study of drug tests, it is suggested that there is probably but one system of proving drugs by which reliable results may be obtained, and that is the system proposed by Dr. J. P. Dake. A properly managed college of provers would do more in ten years for the foundation of homoeopathy upon a scientific basis than will the usual de- sultory work in fifty or a hundred years. No layman is quali- fied for drug proving unless possessed of considerable anatomical, physiological and pathological knowledge, or is under the con- stant surveilliance of a physician. One is convinced of this from the many instances found in the various records of vague INTRODUCTION. xix and inaccurate terms which are calculated to mislead the student of materia medica, e. g., pain in the eye, ear or throat, dimness of vision, diarrhoea, etc. They may mean a great deal, or they may mean nothing, according to circumstances and the significant detail which has been omitted. The symp- toms of this indefinite character, which may be found in this volume, are due to this careless manner of expression, and it is for this reason that "throat" has been arbitrarily adopted in a generic sense, as including both fauces and pharynx. Research in the field of pathogenesy also leads to the con- clusion that for the purpose of constructing a materia medica according to the strictly scientific method, one must not only be a good anatomist, a good physiologist, and a good patholog- ist, but he must also be an expert etymologist. Therefore, should this work not appear perfect in the eyes of the critic, let him bear these facts in mind and be not too harsh in his judgments. Above all, the fact is emphasized that this book is not offered as a substitute for all other works on materia medica. Its mission is two-fold; first, to show the need of a thorough and scientific re-testing of effects even of our best known drugs upon the healthy; and second, to furnish an illustration of the char- acter of work believed to be necessary for the establishment of a practical working materia medica for the future. While be- lieving heartily in the value of these synthetic symptomatolo- gies, the necessity for collecting all possible reliable clinical indications for drugs is also recognized. The one essential point to sustain, is that however we may confuse the purely pathogenetic and the purely clinical observations of drug effects, in our own minds, these two classes of indications should be kept separate in works on mateiia medica purport- ing to be scientific, and in our medical colleges our students should also be taught the difference in the value of the patho- genetic and the clinical indication, and so far as possible they should be taught, first, the pure pathogenetic effect, and in corroboration of the theory the clinical verifications should then be introduced together with whatever of value is known XX INTRODUCTION. empirically of the use of drugs. The study of materia medica needs systematizing, and this is the authors' idea of how to begin to systematize it. A Pathogenetic Materia Medica. ACIDUM CARBOLICUM. REMARKS ON PROVINGS. This symptomatology of acidum carbolicum is drawn from twenty provings and seven poisonings, five of the latter having recovered. Of these records five were from doses of four drops to one gramme; nine from the first to sixth centesimal; six from olfaction; four from local applications, and three from in- gestion of amounts not stated. Only records found in the Encyclopaedia of Drug Pathogenesy have been used. Some records were omitted, as follows: Prov- ing seven, because the prover's symptoms simulated rheumatic pains, from which affection he had previously suffered on sev- eral occasions; proving twenty-one and poisonings one, two, four, six and fourteen as being generalizations, and other poi- sonings because they are either too indefinite or involve dis- eased conditions. GENERAL SPHERE OF ACTION. The principal effect of carbolic acid seems to be upon the nerve centres, and as a result of the evident congestion we find a general muscular enervation as well as mental relaxation, headache, vertigo, coma, with contracted pupils; and in ani- mals, clonic convulsions followed by paresis. Even the gastric symptoms, which are quite marked in the provers, are evi- dently more dependent upon this influence, and not due to local interference of function. 2 ACIDUM CARBOLICUM. SYMPTOMATOLOGY. (Provers, twenty-seven: men, seventeen; women, eight; children, two.) GENERALITIES. A condition of enervation :5 expressed as "languor"2. General relaxed condition of the muscular system5. MIND. Depression of spirits2. Nervousness3. Disinclined to sustained mental effort3. Mental obtuseness4. Unconsciousness6. HEAD. Vertigo8. Head felt hot3: especially in forehead2; sensation of burning in head2. Feeling of fulness in head6: accompanied by headache3. Headache15: with feeling of fulness3; principally frontal10; supra-orbital5; r. temple3; 1. temple2; occiput3; with pain through eyeballs2. Character of pain: acute3, dull4, "neuralgic"2; with feeling of constriction, felt especially in forehead3. EYES. Sense of soreness in eyeballs2. Visual perception interfered with7: pupils immovable3; con- tracted and immovable2. EARS. Tinnitus aurium2. NOSE. Sense of smell unusually acute3. Coryza2. ACIDUM CARBOLICUM. 3 FACE. Sensation of heat in face2. Face cyanosed2. MOUTH. Hyper-secretion of saliva3. THROAT. A feeling of constriction in the throat2. An irritable condition of the throat4: amounting to pain2. STOMACH. Anorexia5. Flatulence3. Nausea10. Vomiting2. A sensation of heat in the epigastrium3. A feeling of weight in the epigastrium3. Pain in the stomach3. ABDOMEN. Abdomen felt distended2. Pain in the abdomen3. STOOL AND ANUS. Diarrhoea3. URINARY ORGANS. Urine very dark colored2. Quantity of urine increased3. Urine scanty2. RESPIRATORY ORGANS. Cough4: dry2, moist2. Respiration slow and irregular3: mucous rales in chest2. CHEST. Pains in the chest4: more especially in r. side3. Oppression of the chest3. 4 ACIDUM CARBOLICUM. HEART AND PULSE. Pulse very weak5: accelerated2. Rapid pulse5. NECK AND BACK. Pain in the back4. Aching sensation in the back2. LOWER LIMBS. Pains in lower limbs5: aching3; a bruised feeling2. Heavy feeling of lower extremities3. SKIN. Eruption on skin3: vesicular, over whole body2. Numbness of skin of hands2. Skin cyanosed2. Coldness of skin2. SLEEP. Drowsiness6. CHILL. FEVER. SWEAT. Chill4. Sweat3: cold2. Felt feverish2. Heat of body increased2. THERAPEUTIC APPLICATION. Here we find a remedy for the common affection, head- ache ; but the carbolic acid headache is often accompanied by a feeling of fulness, most frequently in the frontal region, and especially supra-orbital, suggesting migraine, and is sometimes accompanied by pain in the eyeballs. Or this fulness may become excessive, accompanied by dull pain and vertigo, inter- fering with mental activity and even progressing to uncon- sciousness, with a general relaxed condition of the muscular ACIDUM CARBOLICUM. 5 system and slow, irregular respiration, strongly simulating apoplexy or uraemic coma. The anorexia, sensation of weight and heat in the epigas- trium, with occasional pain and flatulence point to decided interference with the function of digestion; and these symp- toms may be accompanied by nausea, and even vomiting. This nausea was a number of times produced in provers by simple olfaction, and may not infrequently be met with as a reflex disturbance, such as the vomiting of pregnancy. Carbolic acid may also be indicated in pneumonia, with much pain in the chest, especially the right side, with mucous rales, oppression of the chest, respiration slow and irregular, and a rapid pulse, easily compressible. The aching, bruised pain in the back and lower extremities should suggest its use in lumbago, accompanied by a heavy feeling of the lower limbs. The skin also feels the specific effect of the drug, a vesicular eruption being produced, which may extend over the whole body. Other conditions suggested by the symptomatology are '' brain-fag'' as indicated by languor, nervousness and mental obtuseness; tinnitus aurium; and angina faucium, with a feel- ing of irritation, at times amounting to pain, and accompanied by a sense of constriction in the throat. It is also within the province of the present work to mention the local anaesthetic and the antiseptic properties of carbolic acid. In the latter sphere it held pre-eminence for many years; but the results of recent experiments, while not dis- couraging carbolic acid for general use, place several drugs ahead of it as an antiseptic agent. 6 ACIDUM HYDROCYANICUM. ACIDUM HYDROCYANICUM. REMARKS ON PROVINGS. Of the thirty-three proving records, and the twenty-six poisoning cases, resulting from prussic acid, recorded in the Cyclopaedia of Drug Pathogenesy, but fifteen in all have been used in preparing the subjoined symptomatology. The provings in small type have been omitted because not made from simple hydrocyanic acid, and record No. 10, in large type, is rejected for the same reason. In these cases laurocerasus, bitter almonds or some similar preparation is used. Of the poisoning cases five only are fitted for our purpose; one is too indefinite, twelve are not results of the simple acid, three are clinical, one is the result of an unknown quantity of acid and four are post mortem records which are useless for symptomatology. These latter records, however, were valuable in determining the general sphere of the action of hydrocyanic acid. All the records obtained from both provings and poisonings are results of the crude drug; one was from a single olfaction, but the experimenter was very sensitive from previous use of the crude acid. The remaining provers ingested the drug in amounts varying from one drop of an apparently 9 per cent. solution to 326 drops of " tolerably concentrated acid diluted with same quantity of water." The largest doses taken at one time were 86 drops of this last solution, by prover No. 6, and a teaspoonful of Vauquelin's acid (3.3 per cent.), by poisoning case No. 4, both of whom recovered. The cases used are, therefore, proving-records Nos. 1, 2, 3, 4, 5, 6, 7, 8, 9 and n, and poisoning-records Nos. 1, 2, 3, 4 and 14. GENERAL SPHERE OF ACTION. Hydrocyanic acid is neither a deep-acting nor a long-acting drug. Fatal effects follow very soon after its administration; ACIDUM HYDROCYANICUM. 7 i. e., death occurs within a few minutes, certainly within an hour. Judging from cardiac and respiratory disturbances, and from the spasmodic contraction of the general muscular system, in- ference may be made that prussic acid acts powerfully upon the medulla oblongata and the spinal cord. Other cerebral centres are also affected, as is evidenced by the general confusion of the head, dilated pupils, which are in- sensible to light, unconsciousness, etc. Autopsies show the heart to have sometimes ceased beating in strong systole, and at others it is found in diastole and full of dark uncoagulated blood. These discoveries, together with its irregularity both in force and in frequency of beats, sug- gest actual convulsive action of cardiac muscular fibre. The vital constituents of the blood undergo change, as is ex- pressed by its fluidity. The heart's power is weakened and venous congestion is therefore prominent throughout the body, the nobler organs suffering more or less, especially the brain and lungs. The disturbances due to this drug appear suddenly. SYMPTOMATOLOGY. (Provers, fifteen: men, fourteen; women, one.) GENERALITIES. Tonic convulsions*. Lassitude3. Weariness4: exhaustion3. Feeling of weakness4. Did not feel well2. MIND. Depression of spirits and ill-humor2. Indisposition to mental work2. Insensibility4. HEAD. Confusion of head7. Vertigo5. 8 ACIDUM HYDROCYANICUM. Headache7: shooting pain2. Sensation of pressure in iorehead4. Pressure in head worse on right side2. EYES. Sensation in orbits amounting almost to pain2. *Obscuration of vision5: as of a fog before the eyes2. Pupils dilated4: and insensible to light3. FACE. Muscles of face violently convulsed2. Face red3. MOUTH. Sensation of dryness of mouth2. Jaws tightly closed, i. ut this symptom is really valuable, for it was produced in six different subjects from the internal use of the drug. GENERAL SPHERE OF ACTION. Through its action upon the nervous system, both the cerebro-spinal and the sympathetic, the effects of arnica are manifest upon the muscular system, and the fasciae and tendons of the animal body, upon the skin and cellular tissues, upon ARNICA MONTANA. 91 the lymphatics, and upon the system known as the motor- nervous. All experimenters with arnica notice the similarity of its action to those conditions produced by violence to the animal body, such as by blows, falls and similar injuries. If the administration of the drug be continued steadily it has been proven capable of producing fever of a low grade, and even of begetting blood poisoning by purulent infection. Upon the capillary vessels of the body arnica stimulates their function and power of absorption. This drug has the power of producing spinal irritation, paralysis and kindred conditions by its action upon the cerebro- spinal axis through the motor-nerves. Dyspeptic symptoms and even typhoid conditions arise from the irritating and in- flammatory effects of this substance upon the tissues of the digestive canal. Arnica has a decided action upon the skin and cellular tissues of animal life, producing vesicles, and it has in very susceptible subjects developed widespread erysipelatous inflam- mation of a violent degree after its external employment. SYMPTOMATOLOGY. (Provers, forty-two: men, twenty-eight; women, twelve; sex unstated, two.) GENERALITIES. Lassitude5. Malaise2. Inability or disinclination to work4. MIND. Depression2. Anxiety2. HEAD. Confusion of head8. Vertigo12. Pressure in head2. Headache14: parietal2, left side2, in temples3; frontal6, pressive2. EYES. Dimness of vision2. Swelling of eyelids2. 92 ARNICA MONTANA. EARS. Tinnitus aurium2. NOSE. Epistaxis4. F&CE. Pallor of face2. Redness of face2. Itching of face2. Facial dermatitis6: with eruptions4, vesicles3. MOUTH. Increased secretion of saliva3. Scraping sensation in mouth5. Burning in mouth3. Eruption on lips2. THROAT. Scraping in throat8; burning in throat8; burning with scraping4. STOMACH. Eructations7. Vomiting8: violent4. Nausea9. Loss of appe- tite4: with increased hunger3. Pains in region of stomach10: constrictive3, cramping3. Other sensations in stomach than pain or nausea13: pressure5, burning3. ABDOMEN. Rumbling in bowels2. Tympanitic distention of abdomen4. Flatulence4. Pains in the bowels11: constrictive pains2, colic4, cutting with diarrhoea3. STOOLS. Diarrhoea6: with pains3, colic2. Urging to stool3. Bowels sluggish2. URINARY ORGANS. Frequent micturition2. RESPIRATORY ORGANS. Cough2. ARNICA MONTANA. 93 CHEST. Pain in chest3. HEART AND PULSE. Praecordial anxiety2. Pulse quickened4; slowed2; feeble5; irregular5. NECK AND BACK. Pain in the back6: between shoulder blades2; in the spinal column3; dorsal region2; pressive2. Pain in the neck3. LIMBS. Pains in the limbs and joints3: pressive2. SKIN. Skin hot2; cool and dry2. Eruptions on skin3: blisters2. Redness of skin3. Itching of skin4. SLEEP. Somnolence8. Sleep disturbed5: restless3, with dreams4. CHILL. FEVER. SWEAT. Increased perspiration3. NOTE.—The minds of homoeopathic physicians have become so imbued with the idea, and with reason therefor, that arnica is a remedy to be exhibited in all cases of injury that some small explanation here becomes necessary. Although capillary congestions, stases of blood and shock are frequently of an origin other than direct violence, yet certainly very many cases of such conditions are the result of trauma; therefore, although a previous injury is not absolutely essential to the administration of this drug, yet it will be found that the exist- ence of a mechanical shock or injury, past or present, is an indicant greatly emphasizing its selection. 8 94 ARNICA MONTANA. THERAPEUTIC APPLICATION. In scanning the pathogenesis of arnica it becomes apparent that its chief use must lie in diseases and conditions whose pathology presents a state of engorgement and capillary con- gestion ; in this view we find the drug indicated for wounds, bruises, contusions, sprains and injuries of all kinds, both for the primary injury and for the remote or subsequent effects. In all such conditions enumerated arnica has undoubtedly been proven a most admirable remedy for neutralizing the bad effects of all mechanical injuries; ecchymoses and bloody ef- fusions disappear almost like magic under its use, always pro- viding that it be exhibited soon after the injury has been sustained. In cases of shock, concussion, etc., it is also very serviceable in removing the symptoms thereof rapidly and effectively; in contusions there is no drug that will so quickly restore the muscular fibre to its healthy and normal condition as arnica. Arnica is a remedy to be remembered in cephalagia; a very large number of its provers suffered from this symptom. A frontal, pressive headache accompanied with vertigo and more or less confusion of the head should certainly be promptly re- lieved by it. In nosebleed arnica should be consulted, as epistaxis was a feature of four of its provers. In anaemia, with confusion of the head and vertigo, especially if attended by depression of the mind and anxiety, arnica will prove beneficial. In pulmonary hemorrhage, and in fact all kinds of hemor- rhages resulting from mechanical violence, arnica will be found a valuable remedy, and its use is warranted by its known action upon the muscular coats of the blood-vessels. Injuries to the heart from overtaxation, as by climbing, rowing, etc., will be greatly benefited by arnica's proven action upon muscular fibre. ARNICA MONTANA. 95 In gastritis, with much pain, pressure, vomiting and nausea, arnica may be exhibited with considerable confidence. Gastrodynia, like gastritis, has frequently been cured by minute doses of arnica even when the disease is not of trau- matic origin, by its power to produce pain in the stomach of a pressive or constrictive nature, burning, nausea and eructations. The same painful symptoms of gastrodynia indicate the call for arnica in gastric catarrh, acute or chronic, with the addi- tion of disturbance of the abdomen after eating, with flatus and much rumbling of the bowels. In intestinal inflammations, diarrhoea and kindred ab- dominal complaints, arnica is called for by urging to stool and painful colic; if to these symptoms there be added some of the characteristic gastric indications the selection of arnica will be followed by good results. Arnica proves a valuable remedy in myelitis, tabes dorsalis and spinal troubles generally, acute or chronic, with symptoms of pain in the neck and spinal column, ecchymoses upon the skin and coldness of the surface. In erysipelatous inflammations arnica is a valuable and efficacious remedy; the skin is hot, red and painful, the derma- titis results in blisters and the patient complains of heaviness, weariness and soreness. If the erysipelas is of traumatic origin this remedy may be given with the fullest faith in its virtues. Arnica should be of good service in rheumatoid pains if not in genuine inflammatory rheumatism, as witness its power to produce lameness and soreness of the muscles, pains in the joints and tendons, etc. 96 ARSENICUM ALBUM. ARSENICUM ALBUM. REMARKS ON PROVINGS. The symptomatology of arsenicum is based on study of the effects of arsenious acid, arseniate of soda and arsenite of potash. The effort has been made to record only those symptoms pro- duced by arsenicum. Symptoms from the following sources have been incorporated: A series of provings by Prof. Imbert-Gourbeyre, of the medi- cal school of Clermont-Ferraud, and eight of his students; to which is added a proving by an unmarried lady, Mile. E. All of these provings were made with the fourth trituration of arsenicum album, with a supplementary proving of the eighth. A valuable set of provings made by seven members of the Homoeopathic Materia Medica Club of Allegheny county, Pa. Five of these were physicians (one a woman), and two pre- sumably medical students. Five of the provings were made with a tincture prepared by dissolving ten grains of arseniate of soda in one ounce of water; two of them used a preparation having a strength of eight grains to the ounce; and one supplementary proving was made with the twelfth decimal dilution. Two of the provers give also a report of symptoms remaining two years later. A proving of the second decimal trituration of arsenicum album by Dr. A. W. Woodward, and one of the same prepara- tion by A. H. Webster, his student. Two provings by Dr. Grauvogl, of arsenicum album, iox and 3X dilution. One by Dr. Stevenson, with arsenicum album, 3X trituration. One by Dr. Beebe, with arsenicum album, 3X trituration. One by Dr. Lippe, with arsenicum album, 3X trituration. One by Dr. James Jones, with arsenicum album, 3X dilution. ARSENICUM ALBUM. 97 One by Dr. Gouffier, with arseniate of soda. One by Dr. Fredet, with arseniate of soda. One by Dr. Sherwen, with arsenite of potash. One by A. W. W. (Dr. Woodward's provings) with arsenicum album, ix dilution. One by C. S. (Dr. Woodward's provings) with arsenicum album, ix trituration. One by Mrs. M. W. (Dr. Woodward's provings) with arsenicum album, 2x trituration. None of these thirty provers had kept any record of symp- toms previous to proving, although all appear to have been careful observers. Their records are all in which entire reliance can be placed. They are full and furnish sufficient data on which to base judgment. From the many hundred recorded cases of poisoning by arsenic, fifty-six reliable records have been selected, illustrative of the different types of poisoning, and have been used so far as they serve the present purpose. Some of these are in effect provings, and others show the action of arsenic when carried to a point not reached by any prover. At the same time care has been taken not to record any symptoms which show evidence of being due, not to the direct action of the drug, but to a secondary diseased condition set up originally by the arsenic but which has passed from the domain of pathogenesy to that of pathology. GENERAL SPHERE OF ACTION. The employment of arsenicum as a remedial agent in dis- ease, the records of its many cases of poisoning and of its prov- ings upon the healthy have made this drug a familiar one to science. Studied and written about from early times, a vast literature on this subject has accumulated, based upon these investiga- tions. Consequently it is possible to study arsenic from differ- ent sides, and from these studies a good knowledge of the sub- stance may be obtained. 98 ARSENICUM ALBUM. Arsenic is well known as a rapidly-acting and fatal poison, and may be found in every tissue after death; and even when less than a lethal amount has been taken, the results are such as to lead to the belief that its influence extends to every organ. Its action is specific, since its effects are produced not only when the drug is swallowed but also when injected beneath the skin, when applied to abraded surfaces, and when air is inhaled which has been impregnated with arsenic from wall- paper or trituration. It is remarkable that arsenic, when acting as a poison, does not produce similar effects upon all persons, and therefore the description of one case of poisoning will not answer for all. This fact must be borne in mind to avoid error. Thus (i) the force of the poison may fall chiefly on the mucous membrane of the alimentary canal, accompanied by the symptoms usual to irritation of that tract; or (2) the blood may be most directly affected, as denoted by the presence of febrile symptoms; or (3) the nervous system may receive the shock, as evidenced by pain, convulsions, paralysis and collapse. Arsenical poisoning, then, may assume either the irritative, the febrile, or the nerv- ous form. In thus assuming different forms of attack, arsenic resembles the poison of certain diseases, notably cholera. On page 421 (No. 2) Part III. of the Cyclopaedia of Drug Patho- genesy is related a typical case of the irritative form; numbers 8 to n, beginning on page 424, illustrate the febrile, and numbers 13 to 22 exhibit phases of the nervous form. Judging from a study of the action of arsenicum album, its influence is felt first along the upper part of the alimentary canal, producing nausea, pain and other symptoms, and then extends to the abdominal organs. Soon its influence reaches the blood, and, passing with this fluid throughout the body, acts upon every tissue, especially that of the nervous system, the mucous membrane and the skin. It need not excite surprise that a drug whose action on the system is so decided and so general should produce that state of prostration or asthenia into which its victim falls and which ARSENICUM ALBUM. 99 is so characteristic of arsenic; for there is in progress an actual decomposition of tissue—a change from the normal condition to a less vital one—which necessarily results in that sinking of the forces so generally observed. The action of arsenic on the mucous membrane is marked and is best studied where most active; i. e., in the stomach and bowels. The membrane is reddened, caused by the small vessels being engorged with blood so that the deep color is nearly uniform; the membrane is also thickened, softened, easily detached from the sub-mucous coat and patches of extravasated blood appear. This condition extends along the jejunum and ileum, often to an intense degree, and the rectum is similarly affected. The lining membrane of the heart is reddened, the color be- ing diffused or in spots. Fatty degeneration takes place in the muscular substance of the heart, and it is probable that this condition extends, in a greater or less degree, to all blood ves- sels. The blood, after death, is usually dark colored and fluid, with dark clots in cavities, and changes in its composition be- fore death are shown by the presence of ecchymoses and hem- orrhages. Says Stille: "The microscopical and chemical peculiarities of the blood under the action of arsenic are of great importance in relation to the changes which the solids undergo, to the hemorrhages from the nose, the digestive canal, the urinary passages, to the ecchymoses found in the lungs, pleura, pericardium and heart, and to the occurrence of dropsy during the use of this medicine. The production of serous effusions as an ordinary effect, and of chronic anaemia as the consequence of prolonged exposure to arsenical influences, ap- pear to furnish grounds for believing that in sufficient doses, arsenic, like mercury, tends to disintegrate the blood corpuscles, to diminish the proportion of fibrin and possibly also to attack still more directly the vital principle on which the normal qualities of the blood depends." This inference has received confirmation by the process of counting the corpuscles, and the conclusion reached by actual inspection is that both red and IOO ARSENICUM ALBUM. white corpuscles are decreased in number. Arsenic has been well called a protoplasmic poison. The mucus membrane of the air passages is congested and is sometimes covered with bloody serum. There are also indica- tions of congestion, and even inflammation of the lungs. The pleura is congested and effusions of serum into the pleural sac have been observed. Arsenicum is eminently a "characteristic" drug, for while its effects upon one organ differ from those produced upon an- other, yet there are marked characteristics which accompany its action upon the system and cause it to stand out from other drugs in its peculiar individuality. SYMPTOMATOLOGY. (Provers, 30: men, twenty-seven; women, three. Cases of poisoning, fifty-six. Total, eighty-six.) GENERALITIES. Feeling of coldness6: relieved by warmth2. Acutely sensi- tive to cold2. Restlessness20: at night15. Nervousness5. Malaise9. General prostration7. Weakness6. Weariness6. Tendency to faint3. Aching, rheumatoid pains in muscles4; neuralgic pains10; feeling of numbness5. Convulsions9: of the facial muscles4; tetanic3. Paralysis10: motor5; sensory5. Emaciation3. Jaundice6. MIND. Delirium5: active3. Anxiety7: extreme2. Depressed in mind8. Gloomy3; irritable4; listless5; wants to sit or lie quiet3. Loss of power to concentrate the mind7; indisposition to work3, to study3. ARSENICUM ALBUM. lOI HEAD. Confused feeling in the head7. Vertigo3: with indistinct vision2. Feeling of heaviness or fulness12; dulness7. Headache36: severe9, shooting5, dull5, violent2. Pain: felt in the frontal region15 (at the root of the nose2, over the brows8— both sides5); temporal region10 (both sides4); felt in both frontal and temporal regions6; in the vertex2; occiput2; with a sense of constriction at the temples3. Headache felt on awaking4, during the morning3, lasting all day9, felt in the evening2, during the night3. Scalp very sore to the touch4. Falling out of the hair4. EYES. The eyelids are swollen13, stiff3. Itching of lids2. The eyes feels as if sand was within the lids4; as if there was smoke in the room2. Feeling as if the eyes were pressed down by a weight2; they are sunken2; look red as from crying3. Painful condition of the eyes20: burning6; smarting5; sore- ness7 (increased by moving the eyeballs3); pain on pressure3. Inflammation of conjunctiva23: with injection19 (especially along the margins of the lids4); agglutination of lids4; with photophobia7. Lachrymation10: accompanying conjunctivitis6; with smart- ing pain3. The sclerotic coat tinned yellow3. Pupils dilated3. Visual perception indistinct6: connected with burning in the eyes3; with vertigo2. EARS. Noises in the ears3. NOSE. The nasal passages are obstructed9. Burning sensation in the mucous lining of the nose5; the membrane is swollen3; bleeding5. Coryza16: discharge thick9, fluent7, white3, yellow3. 102 ARSENICUM ALBUM. FACE. Anxious expression5; face drawn2; eyes sunken2. The face is swollen21: especially about the eyes14. It is pale4, flushed6, hot3, bluish3, brown in color3. Eruptions on the face13: fine, red rash10 (bright red3); appear- ing in patches3; discrete, inflamed pimples3. Spasmodic action of facial muscles4. MOUTH. Herpetic vesicles on the lips4. Pains in the teeth5. The mouth feels as if on fire4, dry4, sore2; the mucous mem- brane is reddened3, abraded in places3. The gums are tender4, swollen2. Streak at the edge of the gums5: crimson3, white2. Tongue is red4, dry6, moist3, fissured3, corrugated3. Tongue coated17: thinly5; white6, yellowish-white3; coated in the centre and at the back but red along the edges and at the tip3. Salivation6. Taste bitter2, metallic2. THROAT. The throat feels dry8, especially about the fauces2; feels hot4, even to burning3. Sore throat3. Redness of the mucous membrane7, especially in the fauces3. Purplish appearance2; aphthous2. Tough, whitish membrane in spots over the pharynx2. Se- cretion of mucus in the pharynx4: tenacious and starchy2; muco-purulent and mixed with blood2. Frequent hawking5. A feeling of constriction at the throat5. STOMACH. Appetite lost14: with disgust for food3. Poor appetite3. Increased thirst18: intense8; insatiable3. Eructations10: of food3; empty3. Nausea40: ineffectual inclination to vomit2. Vomiting29: frequent5; violent4; sour2; bilious3; green4; mixed with blood and mucus3. ARSENICUM ALBUM. IO3 Feeling of weight at the epigastrium2. Indigestion6: heartburn2. Sensation of heat or burning at the stomach13: extending along the oesophagus2. Pains in the stomach18: "stomach ache"4. ABDOMEN. Soreness or tenderness of the abdomen to pressure10: in the epigastric region6; through the whole abdomen3. Pains in the abdomen20: griping8; sharp7; pinching3; shoot- ing2 ; dull2; felt most acutely in the epigastrium3, about the navel4, throughout the abdomen6. Paroxysms of pain12. Distention of abdomen3. Flatulence11: rumbling in the bowels4 (with pain3). RECTUM AND ANUS. Burning at the anus3: with loose movements2; after the pas- sage2. Excoriations around the anus caused by diarrhoea2. Tenesmus9: with diarrhoea6; with dysentery3. STOOL. Diarrhoea21: frequent2; with griping4; followed by a feeling of relief3. Watery stools6; copious4; dark or black3; green2; mixed with mucus5, with blood2; foetid3; accompanied by flatus3. Constipation2. URINARY ORGANS. Urination difficult3; painful3; accompanied by burning2. Urgent desire4. Urine copious9; scanty4; high colored3 and scanty2. Albumen in the urine8. Hsematuria3. RESPIRATORY ORGANS. Irritation in the larynx3. Hoarseness8. Pain through the lungs3; soreness of lungs on inspiration2. Mucous rales heard on auscultation5. Cough13: dry6, short5, violent2; with thick phlegm3 (yellow- ish2). Difficult breathing (dyspnoea)9. 104 ARSENICUM ALBUM. CHEST. A feeling of tightness or oppression5; soreness in the chest4. Pain in the chest8: sharp stitches2; under right mamma2; on the left side2. HEART AND PULSE. Forcible action of the heart5. Pulsations above the normal19, per minute: 5 to io4, 10 to 204, 20 to 305, 30 to 706. Full pulse3, weak4, small4, hardly perceptible4, irregular2. NECK AND BACK. Stiff neck4. Pain in the back16: across the shoulders3; lumbar region6 (about the loins3); about the sacrum3 (aching2). Pains along the spine running from sacrum to neck2; neck to sacrum2. LIMBS. Pains in the limbs9: cramps4. Twitching in limbs2; numb feeling4. The joints are painful, stiff and crack on motion2. Muscular power lessened5. The hands and feet burn2. Extremities cold8: on the surface2. The nails fall out2. Upper Limbs.—Loss of power in the muscles of the upper limbs5: in the hands2. Weary aching in the arms2. Crampy pain in the muscles3. Pain in the forearm3; numbness2. Numb feeling in the hands2; they glow or burn3. Pain in the fingers7: lancinating3. Muscles tender to touch3. Lower Limbs.—Muscular power lessened6. The muscles of the lower limbs are tender to touch4: even to pain2. Pain in the hips5. Pain in the muscles of the thigh11: ARSENICUM ALBUM. IC>5 aching3, sore pains3; felt on the front of the thigh3, inner side2. Pain in the knees5. Pain in the muscles of the leg13: aching2; cramp in the calves3. SKIN. Eruptions23: bright red rash4 (scarlatinoid2); papular3; urti- carious2; pustular7 (conical pimples on the face, close set and itching2); appearing in irregular patches5. Redness of scrotum, extending to the thigh2. Scalp very tender to touch4. The skin is hot7, cold8, clammy3. Annoying prickling of the skin2. Itching13: persistent2; intense2; general4. Falling out of the hair4; of the nails2. Jaundice6. SLEEP. DREAMS. Very sleepy in the daytime4. Wakeful during the night8; restless sleep6 (full of dreams5); can not sleep, although the desire is strong2; starting from sleep3. Dreams12: of quarreling3; of being in danger2. CHILL. FEVER. SWEAT. Rigors3. Chilliness5. Fever15: of intermittent* type4; remittent3. Chill followed by heat2. Sweat4: preceded by heat2. THERAPEUTIC APPLICATION. In the treatment of disease with arsenicum album its general characteristics, as deduced from the accepted provings, should be borne in mind. These are: * Described as follows: Rigor for five minutes, recurring in three hours. Violent fever, followed by profuse sweats, returning regularly every other evening and lasting until morning. Intermittent fever. Attacks of ague, quotidian and tertian. io6 ARSENICUM ALBUM. Adynamia.—There is scarcely a prover, or one who has in any way felt the influence of arsenicum, who has not experi- enced a feeling of general prostration, often to an extreme degree. This condition is probably due to the paralyzing effect produced on the nervous system through the blood; but, how- ever caused, is very characteristic of the action of arsenicum. Restlessness and Anxiety.—Connected usually with sink- ing of the vital force, is a peculiar restlessness, an inability to remain quiet, most marked at night; due, probably, to the irritation of nerve-fibre produced by the drug. It is an uneasy sense of the presence of an enemy within, which allows no perfect rest. Usually there is also experienced a mental anx- iety. This has been observed by many provers. Malignity.—The effect on the blood resembles that pro- duced by a disease when it assumes the form known as malig- nant. Arsenic thus not only makes an impression on the system, but the impression is grave and the blood being evi- dently under a malign influence the tendency is towards death. Thirst is a symptom very constantly experienced among the provers; it is incessant and insatiable. The Pains are severe, often burning in character, and the parts affected are tender to touch or pressure and sensitive to cold. SPECIAL APPLICATION. (Edema.—The form of dropsy which is under the control of arsenicum is general, or such as is liable to become so, taking its rise in disorder of the heart, the kidneys, or the blood itself. The characteristic puffiness of the face, first noticed in the morning, becomes afterwards more extensive and permanent, the oedema being located usually in the ankles, limbs and abdomen. Conjunctivitis.—Feeling of burning in the eyes which look red as from crying; intense congestion of the entire conjunc- tiva; sensation as of sand under the lids. The eyelids are inflamed on their margins and closed by viscid mucus. The ARSENICUM ALBUM. 107 eyes smart and burn as from smoke; there is free lachryma- tion, photophobia, indistinct vision, severe pain in the eyeballs and over the eyes, pressure on the eyes being painful. Coryza and Influenza are relieved by arsenicum when a feeling of burning is felt in the mucous membrane of the nose, with swelling and obstruction of the nasal cavities. The dis- charge is fluent or else consists of thick, whitish or yellow mucus. Pain in the forehead. Diarrhoea.—The form of diarrhoea calling for arsenicum takes its rise in congestion or inflammation of the gastrointes- tinal tract. Rapid loss of strength and weight, with weak and rapid pulse are present. Pain in the abdomen is severe; the stools are thin, greenish or black; often mixed with blood and very foetid; accompanied by tenesmus. After stool, burning at the anus with excoriation. The abdomen is tender to pres- sure, the surface of the body cold. Cholera.—A remarkable similarity exists between some cases of arsenical poisoning and Asiatic cholera, and arsenicum is one of the remedies to be relied upon in this disease. Besides the general characteristics, there are present violent and persistent vomiting of greenish matter and blood-mixed mucus; sharp griping and burning pain in the abdomen; tongue dry and cracked; icy coldness of the skin, which is clammy to the touch; stools watery, frequent, dark-colored; pulse feeble. Spasmodic action of the muscles. Nephrites.—The symptomatology of arsenicum album does not furnish much evidence of the condition of the kidneys, and yet the presence of blood and albumen in the urine, noted by several provers, are very suggestive symptoms. It seems proper, in this connection, to call attention to the experiments of Dr. Quaglio, published in the Allg. horn. Zeit. LV, 85. To six young cats was given arsenite of potash in doses of from one- eighth grain to one-half grain daily, during several months, un- til all were dead. The urine of most of them, during the period they were under observation, contained albumen, fat globules, renal epithelium and fibrin casts. Post mortem examination of the kidneys showed them in every instance to be greatly en- io8 ARSENICUM ALBUM. larged, hyperaemic, the tubuli full of fibrin, granulations and an oily fluid resulting from fatty degeneration of the epithelial lining of the tubuli. The cortical substance was brownish in color and broken down, exuding a reddish fluid when cut. All of the animals, in fact, gave evidence of the presence of Bright's disease in different stages. There is, consequently, a scientific basis for the use of arsenicum in nephritis. Angina Pectoris.—Arsenicum album will be found useful in angina pectoris when the attack is characterized by great oppression or tightness of the chest with difficulty in breathing, severe pain about the heart and through the chest; pulsations feeble but increased in rapidity; the face is pale and drawn. The attack is apt to come on while walking. Relief comes from keeping in one position and from application of warmth. Attacks occur periodically and the violence of the attack varies from moment to moment. When the heart is affected sec- ondarily in anaemia, chlorosis or other diseases attended by general weakness, resulting from interference with the in- tegrity of the blood, and characterized by feeble and irregular action of the heart with frequent fainting attacks arsenicum is exceedingly valuable. A tendency to fatty degeneration of the heart and other muscles may be successfully checked by the use of this remedy. Post mortem examinations in those who have died from the ef- fects of arsenic show inflammation in many organs, and in some cases steatosis of the heart, liver and other organs appeared. In dilatation, resulting from deposition of fat in the heart, arsenicum is indicated. Diseases of the Skin.—The remedy is useful in cases of erythematous, papular, urticarious, squamous and pustural eruptions distinguished by redness and tenderness, annoying prickling with intense, persistent itching. The eruption often appears in irregular patches. Fever.—The form of fever controllable by arsenicum is apt to assume a remittent or intermittent type, the latter exhibit- ing a sequence of chill, fever and sweat, although one of these stages may be absent. The attack is accompanied by faint- ARSENICUM ALBUM. IOO, ness, inclination to lie down, pain in the limbs, head and chest, with oppression of breathing. Thirst is marked, nausea is felt, the face is pallid and there is restlessness with great prostration. Scarlet Fever, especially the malignant form, may demand arsenicum, and it is especially helpful in post scarlatinal nephritis with its attendant oedema. It is to be relied upon also in yellow fever, variola, and in malignant forms of typhoid fever. 9 no BELLADONNA. BELLADONNA. REMARKS ON PROVINGS. A cursory glance at the Cyclopaedia of Drug Pathogenesy will explain why even a number of provings and parts of prov- ings of belladonna there given are omitted in the following symptomatology. Proving No. 4, being a resume of the symp- toms of twelve persons, is admitted as a single proving after elimination of symptoms occurring in one of their number, No. 5, which are given in detail. No. 6 is also a resume of the records of three provers and is admitted as one, excepting a few symptoms which are specified as having occurred in two of the provers. The record of No. 12 is omitted after the dose of hepar sulphur. No. 18 is entirely omitted on account of the ext. tarax. and pulv. rad. althsea combined with the bella- donna; as also that of poisoning No. 3, because of the camphor contained in the menstruum, i. e., soap liniment. Greding's epileptic cases are all omitted for more than sufficient reasons, as also poisoning No. 18. Proving No. 14 and poisoning No. 7 are not strictly pure, the one being of a sufferer from facial neuralgia, and the other of a patient who had received a dose of Hoffman's anodyne; but their symptoms are considered valuable and are admitted, one or two stars being affixed when- ever symptoms from one or both are incorporated. The whole number of available provings are nineteen ; poisonings, twenty- six ; whole number of adults thirty-two. The preparations em- ployed were the 4th cent, to the 0, fl. ext., liquor bell., powdered root or plant, and berries. All but two poisonings recovered. GENERAL SPHERE OF ACTION. From poisoning by excessive doses of belladonna the follow- ing symptoms are quite constant: Dilated pupils; eyes dry, BELLADONNA. Ill injected and staring; mouth and throat excessively dry, which condition extends downward, causing spasm of the fauces and glottis; a diffuse redness of the skin; violent congestions, especially of the head, with redness of the face and throbbing; vertigo, confusion, hallucination, mania, jactitation of the muscles, convulsions and stupor. From this it appears that by far the most prominent centre of action of belladonna is the cerebrum. We find here active congestion and inflammatory irritation of the nervous sub- stance, prominentlv affecting the sensorium, from which point its action extends over the entire nervous system, "everywhere inducing excited but perverted functional activity, increased manifestation of energy, with diminution of real power and effectiveness. Such are the jactitation in the motor sphere and the delirium in the ideational which it confessedly accom- plishes." (Hughes.) "The most characteristic expression of belladonna is the flushed face, the throbbing carotids, full and bounding pulse, the wild delirium that ever attends its deeper operations." (Cowperthwaite.) Its most important local action is upon the skin and mucous membranes. The skin, especially of the face, becomes hot, red and swollen. There is congestion and dryness of the mucous membrane of the eyes, mouth and throat, often involving the deeper tissues. The urinary organs are also frequently in- volved in the characteristic congestion. SYMPTOMATOLOGY. (Provers, forty-five: men, twenty-seven; women, five; chil- dren, thirteeen.) GENERALITIES. From slight muscular twitchings to violent convulsions12*. Paralytic weakness4. Restlessness"**. Weariness2; general feeling of debility1. Pulsations through whole body2. ri2 BELLADONNA. MIND. Violent rage or anger2*. Hallucinations4*. Delirium20**: mild8*; violent6, loquacious8; with convulsive laughter3. Convulsions4. Unconsciousness12; comatose condition4. Mental exaltation4*. Mind confused3. Felt stupefied2. HEAD. Vertigo15*: increased on movement2. Congestion of the head4; throbbing of head4; congestion and throbbing of head4*. Oppression of head2; confusion of head2. Head feels hot5. Headache12: violent2; frontal3. Pressive pain in temporal region2. EYES. Heaviness of lids2; a feeling as if lids were paralyzed2. Eyelids swollen4. Feeling of dryness of the eyes3*; burning of the eyes3. Conjunctiva injected10*. Appearance as if the eyes swain in tears2. Feeling of water in the eyes2. Eyes protruding7*; unnaturally brilliant5*; wild, staring look7. Dilated pupils26**: especially at night2. Sluggish or immovable pupils8. Double vision9; letters appear irregular or multiple when reading3. Weakness of vision4; obscuration of sight8*. Flickering before eyes2. Sharp pain about orbits4; pain in the orbits2. EARS. Noises in the ears3. BELLADONNA. H3 NOSE. Dryness of nostrils4; sneezing4. Slight discharge of mucus from nose2. PACE. Sharp pains about orbits4. Convulsive contractions of facial muscles3. Redness of face25**. Swelling of face8*: with heat4. Erysipelatous appearance of face8. MOUTH. Great dryness of mouth13*: with dryness of lips and extreme thirst4. Pains in teeth3. Tongue dry5. Tongue furred5; moist2. Abnormal sense of taste7: " sourish "2. THROAT. Dryness of the throat17*: fauces specified3; mouth and throat9*; nose, mouth and throat2. Heat in throat2; burning in throat3. Redness and burning in throat4: fauces specified2. Tonsils swollen2. Sore throat3. Pain in throat6; swallowing difficult5. Hawking of mucus3. Sense of constriction of the throat16*: increased to spasm of pharynx and glottis at every attempt to swallow9*. STOMACH. Loss of appetite7. Thirst4: excessive2. Pressure in stomach3; eructations3. Nausea13; vomiting3. Feeling of heat in stomach2. Pain in stomach4: crampy2. ABDOMEN. Distention of the abdomen8: painful2. ii4 BELLADONNA. Abdomen sensitive to touch3. Griping in abdomen4; dull, heavy feeling in abdomen2. Sharp pain in abdomen8: in inguinal region5; followed by stool3. STOOL. Diarrhceic stool5. Alvine evacuations scanty6. URINARY ORGANS. Urine scanty8; dark colored2. Frequent urging to micturate, urine passed in small quantity and with difficulty6. Urination copious4: and voided frequently2. RESPIRATORY ORGANS. Hoarseness5. Dryness of larynx3. Cough5: dry and short3, "croupy"2. Respiration hurried2. Labored breathing2. Respiration deep, sometimes yawning4. CHEST. Stitches in chest3. HEART AND PULSE. Stitching pain in cardiac region3. Pulse accelerated20: occasional palpitation3. Throbbing of carotid and temporal arteries5*. Perceptible pulsation throughout whole body2. Pulse increased in force6**: and frequency3*. Slow pulse2. UPPER LIMBS. Pains in the shoulders3: tearing2. Pains in arms3, in hands2. Dryness in palms of hands2. Throbbing felt in arms2. Twitching of muscles of arms3. BELLADONNA. "5 LOWER LIMBS Neuralgic or rheumatoid pains in feet and lower extremi- ties3 (described as shooting, drawing, tearing). Coldness of the feet2. Unsteady gait6*. SKIN. Redness of the skin6: a diffuse redness of the whole body, closely simulating the appearance found in scarlatina4**. Redness and swelling of the face resembling erysipelas8. Erythematous patches on different parts of the body4. Slight itching of the skin3. Skin burning5: with partial sweat4. SLEEP. Unusual drowsiness13. Sleeplessness3. Restless sleep2. Involuntary muscular twitchings during sleep2. CHILL FEVER. SWEAT. Coldness approaching a chill2. Feet cold2; head hot4. Sensation of increased heat of skin'4: skin burning, with partial sweat'; increased temperature of body2. Transpiration more or less increased8. AGGRAVATION. On movement: headache2; vertigo2. AMELIORATION. Dimness of vision relieved by coffee2. THERAPEUTIC APPLICATION. Belladonna in importance heads the list of Solanaceae, and has a much wider range of action than any other drug of this group. Dr. Hughes says: "It is probably more frequently pre- n6 BELLADONNA. scribed in homoeopathic practice for acute disease than any other medicine save aconite," and upon a careful study of the symptomatology we find this favoritism well grounded. Motor affections.—Of the motor disturbances of belladonna, eclampsia is the most prominent. The provers experienced from slight muscular twitchings to violent convulsions. It is especially adapted to the excessive hypersesthesia of the motor centres in childhood, and even in puerperal convulsions it may prove efficacious. Also several spasmodic conditions, as pertussis and laryngismus, should derive benefit from bella- donna ; a sense of constriction of the throat, often increased to spasm upon every attempt at deglutition, being of quite fre- quent occurrence in the provings. Suggestions are also found for its use in the spinal paralyses, and especially in locomotor ataxia. The injected conjunctiva, dilated pupils, diplopia, ptosis, darting pains in back and limbs, incontinence of urine, and tottering gait, are found in both prover and patient, though but little testimony of success in treatment can be adduced. Mind.—In the mental and moral sphere belladonna has a varied range of action, including, as it does, mental exaltation, hallucinations, violent rage or anger, and various degrees of delirium. In acute mania and mania-a-potu we should ex- pect decided results, bearing in mind the marked hypersemia of belladonna, with its red face, injected and staring eyeballs, throbbing carotids, and at times furious delirium. In the delirium of fever belladonna may be either the leading or in- tercurrent remedy, especially in those of congestive or sthenic type. Head.—The vertigo of belladonna is due to the general cerebral hyperaemia, and is worse on movement, as is also the headache. In this latter affection we still look for congestive symptoms. The face is most likely hot, red and swollen; the eyelids heavy, with burning and dryness of the eyes; the head hot and throbbing; and the pain more especially felt in the frontal and temporal regions. We may well understand why such a headache would be "worse on movement, or on lying down, and easiest in a quiet sitting posture." BELLADONNA. 117 In the variety of headache known as hemicrania, even vomit- ing may ensue, the nausea being secondary to the cerebral dis- order. Here belladonna is pre-eminently indicated, and if of recent origin may be expected to speedily effect a cure. In cerebral congestion from any cause we will find benefit from belladonna, but more especially in that of childhood which is of such frequent occurrence; and in the effects of sun- stroke it may rival glonoin. Even should the condition be- come one of inflammation of the encephalon, or its immediate covering, the pia mater, belladonna will still do good work, only stopping short of serous effusion. The neuralgia for which belladonna is in such repute finds but moderate expression in the provings; possibly from the fact that the drug was not taken long enough to cause such effect. The only symptoms pointing this way are the sharp pains in or about orbits, and darting, drawing or tearing pains in the back and limbs. Dr. Hughes claims it to be a foremost remedy in neuralgia when occurring above the neck, "it hav- ing little influence over sciatica and other neuralgia." From the pains in or about orbits we might infer that the trigeminus was affected, and should expect to find a flushed face, throbbing head and the pains worse from the least movement. Eyes.—The swelling and inflammation of the eyelids calling for belladonna is usually of an erysipelatous type, with much heat, redness and burning. The conjunctiva shares in the specific action, and belladonna is rapidly curative in the in- cipiency of acute catarrhal and the inflammatory types of strumous ophthalmia, with dryness, burning and injection of the conjunctiva, frontal headache and general symptoms of con- gestion. The curative action of the remedy in iritis may be due to more than the dilating effect upon the pupil; and in retinal hyperaemia and choroiditis with congestive headache, we should certainly turn for aid to belladonna. Mouth.—The pains in the teeth and the general congestive tendency of the drug suggests its use in a common form of toothache, namely, inflammation of the dental pulp, often Il8 BELLADONNA. assuming a neuralgic form, the pain shooting at every throb, the face flushed and the tooth sore to touch. Also in the teething of infants belladonna is especially soothing to the febrile condition, with marked cerebral excite- ment and convulsive tendency. Throat.—The throat seems to be "one of the cardinal centres of the action of belladonna." For simple angina faucium it is almost a specific when there is much dryness, heat or burning, and pain on swallowing. The mucous mem- brane is highly injected, the tonsils frequently swollen, and there may be a sense of great contraction of the fauces, with difficult or impossible swallowing. Stomach and Abdomen.—Although belladonna presumably affects the whole alimentary tract, the thirst and nausea are the only prominent symptoms pertaining to the stomach, the former occasioned by the dryness and heat of the throat, and the latter most probably a sympathetic condition depending upon the cerebral congestion. The distention of the abdomen, with sensitiveness to touch, reminds us of peritonitis; and this distention in some forms of colic, with sharp, griping pains, followed by urging to stool, calls for the exhibition of bella- donna. Urinary Organs.—The condition of the kidneys in which belladonna is found useful, is one in which the primary circula- tion is affected, the hyperaemia causing either diuresis or tem- porary suppression of urine, possibly even resulting in albumin- uria; and Dr. Harley mentions that ingestion of the lemedy may aggravate the condition unless "a very small dose" be given. The condition of the bladder is one of irritation of the mucous membrane, with frequent urging to micturate, the urine being passed in small quantity and with much difficulty. Generative Organs.—From the provings of belladonna we can gather no evidence of uterine disturbance; but by an easy inference drawn from the known condition of spasm, conges- tion and inflammation caused by the drug, we can safely advise BELLADONNA. 119 its use in several such conditions of the uterus and ovaries. In uterine inflammation, either following congestion or sub- involution, with swelling of the abdomen and sensitiveness to pressure, accompanied by frequent attempts to micturate, with scanty urine, belladonna is useful. Respiratory Organs.—The cough of belladonna is dry and short, accompanied by a feeling of dryness of the larynx, and not infrequently also with hoarseness. Skin.—Erysipelas is decidedly under the control of bella- donna; the skin is smooth, dry, hot, shiny, with redness and swelling, some itching and burning, and with possibly a few small pimples. The face or head is the more common seat of the disease, which is accompanied by much throbbing, and there is usually a tendency to brain irritation. Even should there be metastasis to the brain belladonna may still be relied upon. Circulation.—The fevers of belladonna seem to be those in which there is hyperoxidation in the nervous centres, and which are typified in those of a typhous kind, though not usually in the incipience, unless in the brain fever of over-ex- citement. The cerebral symptoms must not be confounded with those resulting from the high temperature, such as we may meet under aconite; but later, when the brain itself be- comes involved. Here we will expect to have pulse much increased in force and frequency, face bright or deep red and turgid, pupils dilated, eyes injected and staring, skin hot and dry, delirium, at times furious. But occasionally there is un- usual drowsiness, frequently accompanied by muscular twitch- ings during sleep. Of the exanthemata, scarlatina is most prominently under the control of belladonna. The vomiting is at times violent, evidently from cerebral irritation, which is also evinced by other symptoms, from simple twitching to violent delirium. The rash should be of the smooth, Sydenham variety, the throat is bright red with swollen and glistening tonsils, the tongue is furred, or red and dry, with extreme thirst, and there may be severe throbbing headache. 120 BELLADONNA. A careful study of the symptomatology and general sphere of action of belladonna, may lead the practitioner to prescribe it in various other conditions of disease wherein it will prove to be the similimum. BROMINE. 121 BROMINE. REMARKS ON PROVINGS. Of the twelve provings and four poisonings of bromine in the Cyclopaedia of Drug Pathogensy, the following have been omitted from this symtomatology: Poison case No. 3 con- tains symptoms from clinical cases, and is therefore ineligible. No. 5 is classed with No. 2 as a single proving, both being made in the same individual. Nos. 7 and 8 are also classed as one proving for the same reason. Of the ten provings and three poisonings utilized, ten are presumably from men and three are uncertain. The effects noted were obtained from the first dilution to eight drops of the pure drug, from inhalations of the vapor, and in one poison- ing case from one scruple taken at a single dose. Owing to the powerful irritant quality of bromine a question might arise concerning certain symptoms being more than local effects. Hence any synthesis which includes one or more of these debatable symptoms is designated by a star, although in many cases such symptoms are supported by others of undoubted dynamic origin. GENERAL SPHERE OF ACTION. Bromine is a powerful irritant, even the fumes of the drug causing irritation or inflammation of all the mucous surfaces with which it comes in contact. Because of its volatile character this corrosive action is usually more manifest upon the respiratory organs of the provers, causing coryza, more or less salivation, a feeling of roughness and soreness of the throat, much oppression of the respiration, and a tickling, dry cough, with more or less pain 122 BROMINE. in the chest. Accompanying this irritative action we find spasms of the muscles of respiration and deglutition. The mucous membrane of the stomach and bowels also shows evidence of the drug's action, it here causing nausea, colicky pains, and a tendency to diarrhoea. SYMPTOMATOLOGY. (Provers, thirteen: men, ten; sex not stated, three.) GENERALITIES. A feeling of anxiety2. General weariness2. HEAD. Vertigo': confusion of head2. Headache6: pains in head sharp and stitching2. EYES. Conjunctivitis, with slight pain in and over the eye2. NOSE. Coryza4*: with epistaxis2. "Stopped up" feeling of nose2. MOUTFT. More or less marked salivation5*. FACE. Heat of face2. THROAT. Roughness of the throat3*. Soreness of throat3*. Difficult deglutition2. STOMACH. Eructations6. BROMINE. 123 STOMACH. Eructations6. Nausea5*: with inclination to vomit2*. Heat in stomach4*. More or less pain in stomach2*. ABDOMEN. Sharp pain in bowels5: "pinching"2. Rumbling in abdomen2. STOOLS. Diarrhoeic stools4. URINARY ORGANS. Increased urination3. RESPIRATORY ORGANS. Respiration much oppressed or impeded8*: spasm of mus- cles of respiration5*. Cough5*: tickling with dry cough3; stitches in lungs with cough3. CHEST. Feeling of tightness of chest3*. Pains in chest3. HEART AND PULSE. Pulse increased in frequency5: increased in volume3. Diminished frequency of pulse2. BACK. Pains in dorsal region2. Chilliness down back2. LOWER LIMBS. Pain in knees2. SLEEP. Unusual sleepiness during day3: wakeful at night2. 124 BROMINE. CHILL. FEVER. SWEAT. Coldness down back2. Sensitive to cold air2. THERAPEUTIC APPLICATION. The action of bromine is more prominent upon the respir- atory organs. Here we find dry cough, spasm of the muscles of respiration, breathing impeded or oppressed, a rapid pulse, and a general feeling of anxiety; all of which symptoms point to its usefulness in croup, where, indeed, its efficacy has been frequently tested with success. The pains and tight feeling in the chest observed by the provers lead us to infer that even bronchitis or pneumonia may find in bromine a similimum should other remedies be found wanting; and for dry, tickling coughs, so frequent in the colder climates, it should give immediate relief. In influenza we have here a promising remedy, the provers "having experienced much coryza, with at times epistaxis, smarting and inflammation of the conjunctiva, and lachryma- tion. Accompanying these symptoms we also find sensitive- ness to cold air and a feeling of weariness, both concomitants of the first, and even second stage of influenza. Headache and vertigo are prominent in the provings, and bromine may be of use in these disorders when idiopathic; but the most probable benefit in such ailments will be obtained when they are the result of gastric derangement, as here bromine may quite cover the whole ground. More or less pain in the stomach, with heat and burning, nausea and eructations, followed by rumbling and pinching in the bowels and diar- rhoea would point to a well developed case of indigestion. The provings exhibit no evidence upon which to base the use of bromine in diphtheria, its sphere in this disease being most likely that of a germicide: and, indeed, we may well believe the claim that bromine is in this respect the equal of chlorine. BRYONIA ALBA. 125 BRYONIA ALBA. REMARKS ON PROVINGS. In preparing this study of bryonia the Cyclopaedia of Drug Pathogenesy alone has been used. Although the "British Pharmacopoeia" allows bryonia dioica to be substituted for bryonia alba, yet this substitution is not admissible here, and therefore the provings of bryonia alba only are utilized. The provings of bryonia dioica found recorded in the Cyclopaedia are by Dr. William Huber, Dr. Watzke, Dr. Wiirstel, and Aloys Loewy, a dentist, who are noted, respectively, as provers 4, 13, 17 and 18. Besides these, four poison cases are also excluded. The latter are cases 1 and 7, results of bryonia dioica; case 2, which is purely clinical; and case 3, which is too vague. All the remaining reports have been utilized. They consist of tests made with preparations of bryonia alba, ranging from the freshly-expressed juice up to the eighth decimal dilution, in all of which cases the drug was administered by ingestion only. Cases 4, 5 and 6 of the poisonings have also been used. The synthesis is therefore drawn from twenty-five cases in all. GENERAL SPHERE OF ACTION. Bryonia alba, in common with a large class of our most useful drugs, attacks the nerve centres of vegetative life. Hence, we find much functional disturbance throughout the organism ; but, in so far as we are able discover, there is no unvarying sequential order in which the various tissues of the body are affected. As shown in post mortem appearances in the lower animals dead from the effects of the white bryony the mucous mem- brane of the respiratory tract becomes congested and even highly inflated; the lungs becoming so profoundly affected as to 10 126 BRYONIA ALBA. sink in water. The intestines are inflamed, with ulcerative tendency, and the liver and the kidneys also show an ab- normally plethoric condition. The serous tissues are also affected; the cerebral and spinal meninges are congested, and even the vessels of the brain are too full of blood, while the pleural sac is inflamed. The post mortem lesions, which have been found in dogs and rabbits, probably exist to a greater or less degree in the human prover, as is suggested by both objective and subjective symp- toms of the drug. Furthermore, we have from man satisfactory evidence of the action of bryonia alba upon the muscular system and upon the circulatory apparatus. SYMPTOMATOLOGY. (Provers, twenty-five: men, twenty-one; women, three; sex not stated, but probably male, one.) GENERALITIES. Languor3; weakness5; lassitude7. Disinclination for work2. Fatigue4; prostration7. Pains in various parts of the body3. MIND. Irritability4; morose, ill-humor*. Depression of spirits4. Feel- ing of anxiety3. HEAD. Confusion of head6. Vertigo8. Headache19. Character of pains in the head: pressive10, pressing from within outwards2, drawing3, dull5, sharp2, tearing2, throbbing3. Headache in frontal region12 (pressive5, dull2, over right eye3); in temporal regions9 (right temple3, left temple2); frontal and temporal regions5 (pressive in character3). Pressive pain over left eye3; in forehead and occiput2; in temporal and occipital regions2. BRYONIA ALBA. 127 Parietal headache2. Pain in the occiput7. Sensation of heaviness of the head2. Sensation of weight in the head2. Sensation as if scalp were stretched2. Tenderness of scalp2. EYES. Lids swollen and reddened2. Irritation at right inner canthus2. Lachrymation of right eye8: with burning2. Pressive pain in eye3: in right eye2. Conjunctiva of right eye red2. Pains in right supra-orbital region3. Vision indistinct2. EARS. Noises in ears5: whizzing in character2. NOSE. Epistaxis2. Frequent sneezing6: with coryza2. Nasal catarrh6. FACE. Sensation of drawing or stiffness of face4: stiffness of facial muscles2. Perspiration on the forehead2. MOUTH. Taste bitter3, sweetish2, insipid2, pappy2. Tongue coated3: white2. Tongue dry2. Excessive flow of saliva4. Toothache4: on right side2, in upper molars2. THROAT. Irritability of the throat9; scraping sensation in the throat2. Sore throat2. Hawking of mucus from the throat3, with disagreeable taste of sputa2. Tough discharge from throat ad- hering to palate2. Dryness of palate2. 128 BRYONIA ALBA. STOMACH. Appetite impaired10: complete anorexia5. Thirst7: desire for wine2. Eructations8: tasting of food eaten2; empty eructations2. Nausea9. Sensation of fulness of the stomach5; of pressure in the stomach4. Gastric region sensitive3: to pressure2. Feeling as of a stone lying in gastric region3: expressed by two provers, as a pressure as if from a stone in the stomach. Pain in the stomach6: constrictive in character3. Uneasiness in region of stomach2. Sensation of heat in stomach2. Sensation of distension of stomach5: distension4; painful distension2. ABDOMEN. Pain in umbilical region5: coming suddenly3; pinching in character2. Stitches in umbilical region2. Pain in hypogastrium2. Pain in inguinal region4: left inguinal region2; pressive pain2. Abdomen distended6: tympanitic3. Pains in abdomen12: griping7; pinching4; griping and cut- ting2. Intestinal disturbance14: rumbling6 (pain, distension, etc.); followed by loose stool5 (which relieves2); followed by passage of flatus3 (which relieves2). ANUS AND RECTUM. Sensation of heat in anus5: burning in anus following diar- rhoea*. Stools cause soreness of anus2. Sensation of heat in rectum3: burning in rectum following diarrhoea2. STOOL. Constipation9: with small4, hard motions5, and urging to stool4. BRYONIA ALBA. 129 Diarrhoea8. Loose stools8: watery3, fluid3, liquid2. Stools soft6, copious5 (and loose3), loose with discharge of flatus3, acrid2, papescent4. Loose, offensive stools2. Inclination to stool5. Urging to stool6: preceding the action4. Pain in abdomen preceding and accompanying stools6. Rumbling in abdomen with urging to stool2. Stool followed by sacral discomfort2. Emission of flatus10: offensive3. URINARY ORGANS. Frequent micturition5. Urine increased in quantity7. Urine increased in quantity and passed frequently3. Urine scanty6: and hot2. Urine highly colored2. RESPIRATORY ORGANS. Quality of the voice altered4: hoarseness2. Cough8: dry cough5; cough with expectoration of mucus4, which is greenish in color2; irritation of the larynx with cough3, which is caused by tickling2. Respiration impeded11: the cause expressed as constriction of the chest6, or as oppression5; the breathing is accelerated4, and there is inclination to breathe deeply2 (sighing?). CHEST. Pressure in right chest3. Pains in the chest13: confined to the sternal region5. Pains in the sides of chest7: left side6, right side5, both sides4. Chest pains are stitching7 (in the evening2); aching2; shooting2; tear- ing2. They are also pressive2, or throbbing2. The pains are aggravated by movement of chest muscles*: by inspiration3. Pectoral muscles are sore to touch2. HEART AND PULSE. Oppression in cardiac region2. Heart's action is quickened6. The pulse is strong3; full and hard2; weak2. 130 BRYONIA ALBA. NECK AND BACK. Pain in the neck5: drawing2, tearing2. Stiffness in muscles of neck2. Drawing in the nape2. Backache2. Pain in dorsal region2. Drawing between shoulders2. Pain in lumbar region4: tensive2; dull ache2. Pressure in loins2. Pain in sacral region3. Pain in sacro-iliac region2. Pain in sacro-lumbar region3, tensive in character2. Tension in the sacrum2. LIMBS. Tired feeling in the limbs4: lower limbs2. Pains in the limbs18: in joints9; drawing in character7; tear- ing7; stitching5; "rheumatic"2; aggravated by movement7. Pains specified as occurring p. m4. Pains in shoulders8: in right shoulder4, in left shoulder3, in both shoulders2; tearing2, rheumatic2. Stitches in left shoulder2. Powerless feeling in shoulder on attempting to move arm2. Pains in arms7: right arm3, left arm2, both arms2; drawing4, tearing3, stitching3. Pains in elbows2. Pains in forearms6: right forearm2, both forearms3; drawing4, drawing tearing2, pressive tearing2. Pain in wrist5: both wrists2; drawing in character2. Pain in hand2. Pains in fingers6: in finger joints5, fingers and finger joints painful and swollen2; pains are tearing2, draw- ing2, stitching2, and are aggravated by movement2. Pain in hips3: right hip2, left hip2; aggravated by movement2. Pain in knee9: left knee6, right knee4; drawing3, tearing and drawing2, "rheumatic"2; aggravated by motion4. Tendency to disintegration of skin of knee joint2. Great weakness in the knees3. Knees feel tired2. Pains in the legs5: left leg3, right leg2, both legs3; in the calf4 (left calf2); in shin3; left shin2, both shins2; drawing in character3. Pains in ankle4: right ankle3. Pain in foot6: instep2, heel2; drawing in character4. BRYONIA ALBA. 131 Cramp of sole of foot2. Pain in toes8: of right foot4, both feet2, right great toe2, left great toe2; drawing4, or tearing in character3. SKIN. Skin eruption3: of a vesicular character2. Eruption on the back2. Skin of knee joints irritated2. Itching of different parts of the skin5: of the skin of the back2. Burning pain in skin2. Perspiratory function stimulated2. SLEEP. Yawning3. Sleepiness4. Restless sleep8. Sleep disturbed by dreams7. Dreams9: ex- citing6. CHILL. FEVER. SWEAT. Shivering7: followed by heat2, or with pains in limbs2, or with loss of strength2. Cold and hot by turns3. Cold feeling in back2. Sensation of increased temperature of body6. Increased secretion of sweat8. AGGRAVATIONS. Pains in general are worse from motion12: of chest5 (by deep inspiration2), limbs2, hip joint2, knee2. Headache aggravated by motion2. Pains aggravated from touch3. AMELIORATIONS. Perspiration relieved rapid pulse2. Abdominal pains relieved by emissions of flatus3. Pains better from movement4: pain in leg "going off while walking"2. 132 BRYONIA ALBA. THERAPEUTIC APPLICATION. In the light of the foregoing synthesis the following patho- logical conditions are suggested, in which bryonia alba may be employed with reasonable expectation of beneficial results: Headache.—The pain is located either in the frontal, tem- poral or occipital region. Its distinctive character is pressive, a pressing from within outwards, as though the head were too full of blood, which is probably the case. The headache may, therefore, be considered of the congestive variety. This headache is sometimes present in typhoid fever, gastric disturbance, or simple cerebral congestion. Meningeal Inflammation.—When the membranes of either the brain or spinal cord are inflamed the drug should be studied. In the former trouble headache is prominent; there is pressive sensation from within outward, and a dull heavy feel- ing of weight in the occipital region. The head is confused and vertigo is present. As reflex symptoms there may also be nausea and emesis. Nasal Catarrh.—When there is frequent sneezing and lachrymation, with fluent nasal discharge, headache, and other concomitant symptoms of the drug, bryonia is indicated. Epistaxis may also be present from congestion of the mucous membrane. Acute Angina.—When the inflammation has extended down the respiratory tract from the nares, the throat may be- come irritable, causing a scraping sensation which induces hawking, with the result of raising tough mucus, which adheres to the velum palati. The latter feels dry; the mucus may have a disagreeable taste. Laryngitis.—There is hoarseness of the voice, tickling in the larynx, with dry cough and mucous expectoration. Bry- onia may be thought of in croup. Bronchitis.—The mucous lining of the bronchial tubes in inflamed, and there is dry cough, with pain in the chest on BRYONIA ALBA. 133 deep inspiration; also a sense of constriction of the chest, and the breathing is accelerated. In the early stage the drug is probably best indicated. Pneumonitis.—When the inflammation has extended down into the air vesicles there will be the characteristic dry cough, with mucous expectoration, which is sometimes greenish in color. The breathing is accelerated, with a feeling of op- pression and an inclination to breathe deeply, which is checked by the acute pain thus caused. The heart's action is acceler- ated, there is thirst, and the patient is more or less prostrated. The pain may come only when inspiring deeply, or it may be continuous; in the latter case movement always aggravates Should the pain be continuous it will be stitching, shooting, tearing, throbbing, or pressing; but whatever be the particular variety, the pain is characteristically acute. The physical signs we would expect to be those of the first stage of pneumonia; but even in the period of hepatization, if the general symptoms of the drug be present, it should be prescribed. Pleuritis.—The febrile signs and acute chest pains, which are aggravated by every movement, together with the dry cough, point to this painful malady. Probably no drug is more homoeopathic to pleurisy in its outset. Derangements of the Digestive Organs.—The digestive organs manifest numerous signs of derangement. In dyspepsia the tongue is coated, there is bitter taste, anorexia, sense of fulness of the stomach with pain; also a feeling as of a hard substance lodged therein like a stone. There are nausea, eructations of ingested food, and even retch- ing, with emesis. There may be also decided thirst, to quench which the patient may find wine especially to his liking. With the gastric symptoms the head may ache, in which case the frontal region will be affected, the pain being of a dull pressive character. Colic should find relief from bryonia when the abdomen is distended and there are pains over the whole abdomen, gener- 134 BRYONIA ALBA. ally acute, accompanied by griping, pinching, or cutting, and being relieved by the passage of flatus and by loose stool. In diarrhoea the stool is preceded by pain and rumbling in the abdomen, with tenesmus. The stool is loose, sometimes watery, offensive and copious, but without characteristic color. Sometimes the stools are acrid, in which case there is burning in the rectum and anus following the evacuation, but there is no objective excoriation. The opposite condition of constipation of the bowels may exist, in which case the stool is small and hard, and attended by more or less tenesmus. Urinary Organs.—The urine is passed frequently in large quantities; hence bryonia should be studied in diabetes insipi- dus. The urine may also be scanty, and in the early stage of nephritis the drug should be studied. The Circulatory System.—In irritable heart, and in in- flammation of the cardiac tissue, the drug may prove useful. The Muscular System.—Rheumatism. If there be any truth in homoeopathy, then bryonia is par excellence a rheu- matic remedy. The drug produces muscular pains throughout the body in all degrees of intensity, which are usually aggra- vated by moving the parts affected; but this is not always true, as some cases are relieved by movement. Not only is muscle tissue attacked, but the serous tissues of the joints also suffer; and while bryonia is indicated in the early stage of the disease, the brain, or other organs constituted of serous tissues is involved. The characteristic pains of rheu- matism are chiefly drawing or tearing. The Skin.—This tissue shows signs of irritability by itching at various points, and also appearance of an eruption of a vesicular character. Typhoid Fever.—The intestinal disturbance, especially the constipation, together with anorexia, headache and confusion of head, epistaxis, mental depression, persistent dreaming, and general prostration of the vital force, would suggest bry- onia in typhoid fever. CAMPHORA. 135 CAMPHORA. REMARKS ON PROVINGS. In preparing this condensation of the provings of camphor the Cyclopaedia of Drug Pathogenesy has exclusively been used; and although the results obtained are exceedingly meagre, yet no other conclusion could be arrived at by a rigid prosecu- tion of the method agreed upon. All the provings in the above-mentioned work have been utilized with the exception of those of Lippert and Kneschke, who having taken the liberty to mix their camphor with mag- nesia could not be said to have experienced strictly a proving of camphor. The poisoning case of Miss X., in the fifteenth part of said work (Appendix), has been used partially; the symptom fol- lowing the administration of the sulphate of zinc, used as an antidote, of course are valuable to one endeavoring to obtain a perfect pathogenesis of camphor, but only those symptoms this lady experienced prior to the antidote have been included in this summing up. As all the provers took more or less strong preparations of the gum the symptoms produced were invariably well pro- nounced. GENERAL SPHERE OF ACTION. All the effects of camphor originate from its action upon the cerebro-spinal nervous system. Upon the sensorium it acts powerfully and quickly, causing vertigo, confusion of ideas, convulsions, etc.; upon the sub- sidence of these manifestations the reaction is found to be intense heat and vascular excitement in the head. There has been some dispute as to the exact modus operandi 136 CAMPHORA. of camphor, but Professor Stilles' opinion upon the subject is now generally accepted: that large or toxic doses produce chill and depression first; and if the subject reacts the secondary effects are those of simulation and excitement; that small or medicinal doses cause this stimulation and excitement without any previous depression. The coldness and torpor which camphor causes in the stomach and bowels are characteristic of its primary action upon the mucous coating of these viscera ; this is caused by its action upon the cerebro-spinal system, and the great coldness of the skin and surface which it evolves is caused by its in- fluence upon the sentient nervous system. Upon the genitalia its first effect is impotence with coldness and relaxation of the organs. On the physiological action of camphor Dr. Chas. F. Phillips says: "It is singular how little is yet known with accuracy upon this point, notwithstanding the large number of strong statements that have been made by various writers respecting its action." It is certainly known, however, that camphor in very large doses will cause death, preceded by delirium, coma and convul- sions. Upon animals many persons have experimented with large and fatal doses, and the post mortem appearances have proven that besides its action on the nervous centres camphor has the power of a direct irritant to the alimentary canal, and also to the mucous membrane of the genito-urinary organs. One of the phenomena which has been often, though not always, noted in severe cases of camphor poisoning is dilatation of the superficial vessels, especially those of the head and face; this is usually accompanied by delirium. On the whole, while our knowledge of the physiological action of this substance must be admitted to be very partial and confused, it is more than probable that Nothnagel is correct in his statement, that the apparent conflicting attributes of seda- tion and stimulation which have been ascribed to this drug are both correct, the difference being a matter of dose and occasion. CAMPHORA. *37 SYMPTOMATOLOGY. (Provers, forty-eight: men, thirty-five; women, nine; sex unstated, four.) HEAD. Confusion in the head11. Vertigo8. Headache7: frontal2. STOOL. Constipation2. URINARY ORGANS. Frequent emissions of burning urine2. SEXUAL ORGANS. Male.—Sexual instincts and powers excited3. Involuntary seminal emissions2. HEART AND PULSE. Pulse slower than normal5; faster than normal7; vibratory2. SKIN. Perspiratory action of the skin increased5. Increased sensation of heat in skin3. Feeling of coldness over the entire skin surface5. Clammy sweating over the whole body2. Extremities pale, cold and numb3. THERAPEUTIC APPLICATION. From the limited number of verified symptoms which are herein produced it will be seen that in a strictly homoeopathic sense the use of camphor is very restricted; there are no grounds upon which a homoeopathic physician can prescribe the drug upon the theory of similia, for coryza for instance, for i38 CAMPHORA. the provings show no such condition to have been produced j its action in such cases can be explained by and attributed to its astringent properties only. In the provings of camphor we find that it produces vertigo and congestion of the head, and that it causes derangement of the faculties; therefore vertigo will often yield to its adminis- tration, and experience has proven that it is valuable in vertigo from insolation, especially if along with the sunstroke there are symptoms peculiar to camphor, such as a feeling of cold- ness with clammy sweat over the entire skin surface, and the extremities are cold and numb. Camphor may be found at times of good service in inflamma- tion of the bladder and urethra, but when it is given there must co-exist a cortain amount of nervous shock, as evidenced by coldness of the skin surface, clammy sweating, etc. The main sphere of camphor, however, lies in its use in Asiatic cholera and choleraic affections, but as the provings fail to show any specific action upon the intestinal mucous mem- brane we must again prescribe it upon its concomitant symp- toms, to wit: the coldness of the entire skin surface, the general clammy condition of the skin, and the cold and numb extremi- ties, and it is well known that the symptoms revealed are present in this grave disease. CANNABIS INDICA. !39 CANNABIS INDICA. REMARKS ON PROVINGS. In the Cyclopaedia of Drug Pathogenesy are to be found thirty-eight records illustrating the action of Indian hemp upon human beings, twenty-seven of which are grouped under provings and eleven under poisonings. Upon closer examina- tion, however, it is discovered that among the provers, records 4 and 5 are of single experiment. This is also true of records 6 and 7; and we, of course, use each of them, respectively, as single records, making two instead of four. Record 21, besides embodying Gautier's experiments, is in- troduced by a limited account of the effects of haschish upon his friend Dr. ------. This latter we have used as a separate record. In record 26, O'Shaugnessy's history of effects upon several pupils, which, down to the sixth line, is a generalization, is used in foot notes whenever the generalization verifies analogous symptoms in the synthesis. The balance of the record is legiti- mate material. Likewise in the succeeding record (which, by the way, should be numbered 27), in observation "d," Dr. Pease's generalizations from experiments upon about thirty of his friends, are also used as foot notes only. Observation "e," of the same record, is omitted because there is but one sup- posed result summarised from the two ladies noted, which is by no means uncommon with many women whose health is con- sidered good, i. e., "profuse menstruation which lasted five days." The second poisoning record is a generalization of effects upon three men, and though it is interesting as illustrating the possibility of a fatal termination from an overdose, yet it is too indefinite for use. 140 CANNABIS INDICA. Poisoning case 4 is a woman said to have had spasmodic asth- ma, but as asthmatic symptoms are not prominent we have thought fit to utilize the balance of the record, which has no bearing upon asthma. Poisoning case 5 contains material for two distinct experiments, and we have so used it. Poisoning 6, that of a woman, is rejected, because in the short record no symp- tom is reported which is congruent with any of those recorded in all other reports. Poisoning cases 7, 9 and 10 are omitted because clinical, and No. 8 could not be used because it is not only a clinical record, but also because of the hypersensitive skin of the subject, and also because he had formerly contracted syphilis, had used iodide of potassium, and the grain of cann. ind. was given for a pain in the chest. The use of all other drugs by the various experimenters, in connection with the hemp, has been duly considered, and no symptoms have been used that the reporters have recorded sub- sequently to taking the second drug, except in the cases where aromatic spirits of ammonia were taken with the haschish, the evanescent character of the ammonia being such that all its effects must have rapidly disappeared, leaving the longer- lasting effects of cannabis indica undisguised and unimpaired. Having made these alterations and corrections which are necessary, we find the material for our work to consist of thirty- one records, of which twenty-six have been classified as prov- ings and five as poisonings. In all these records the effects have been obtained from the crude drug, in doses ranging from ten drops of the tincture to one and a half teaspoonfuls of a paste made from the dried leaves of the plant. This latter amount was taken by Mr. Bayard Taylor, and also by his travel- ling companion, Mr. Carter Harrison, and, as stated by the former, this was "enough for six men." Besides this paste and the tincture the drug was used in the form of solid and fluid extracts, "Birimingi," and buds of the dried plant. A profound effect was also obtained by smoking the drug. A point worthy of note is the high class of minds by whom CANNABIS INDICA. 141 haschish has been tested. We have the traveller and poet, Bayard Taylor, his friend and companion, Carter Harrison, who afterwards became Chicago's assassinated Mayor, the French poet Theophile Gautier, etc., besides physcians, all educated men, well qualified to illustrate the striking mental effects of the drug. GENERAL SPHERE OF ACTION. The promptness of the action of cannabis indica depends upon the size of the dose taken and the susceptibility of the in- dividual to the drug. The shortest interval reported in our records as having elapsed between ingesting the drug and its first results is fifteen minutes, and the longest interval as twenty- eight hours. The continuance also depends upon the factors mentioned. A number of experimenters have experienced effects for days after the last dose, among whom are, notably, Dr. S. A. Jones and Mr. Bayard Taylor. The former reports undoubted results as continuing for two weeks, and the latter did not recover "for days." The average experimenter, how- ever, attains his normal status within twenty-four hours. Can- nabis indica, therefore, may be considered a comparatively prompt, but not a long-acting drug; and when prescribed in disease, results should be expected soon after its administration. There are no cases of deaths reported from the effects of cannabis indica, either in man or in the lower animals; we have, therefore, no post mortem lesions to guide us in interpret- ing the modus operandi of the drug. But the symptomatic indications are so decided that there need be no hesitancy in pronouncing these effects due to the action of the drug solely upon the nerve tissue. So strongly does the symptomatic synthesis point to this fact that we may safely say there is probably no drug in the known materia medica whose action is so entirely limited to disturbances of the functions of the nervous system. In using the expression, nervous system, we mean both the 11 142 CANNABIS INDICA. voluntary and involuntary systems. Chiefly and most power- fully, however, are the cerebro-spinal centres disturbed. The cerebrum yields to the toxic influence, and we find more or less disturbance of the various mental faculties, viz: " Correct appreciation of the physical relations of things is to a greater or less degree perverted; illusions of various kinds occur, in which the special senses of sight, hearing, smell and touch be- come involved. The emotions and the ideational sphere are also invaded. Ratiocination, and the dependent will-power and memory, pass through various states of modification, from a primary over-excitement, stimulation, to a secondary weak- ness, obtuseness and final complete temporary obliteration. As a result of this disturbance in the cerebrum head, eye and ear symptoms supervene, and the sleep is also disturbed and filled with dreams. Indications that the vegetative nervous system is involved are found in the disturbance of the circulatory, the respiratory and the urinary functions. Furthermore, the perversion of the normal dynamis of the muscular system exhibited in languor, weakness and cataleptic manifestations, besides the peculiar general nervous "thrills," point still more strongly to the influ- ence of haschish upon the sympathetic nervous system. To the two great systems of nerve-force generation, there- fore, must we look for the cause of all disturbances resulting from the great Indian nervine, haschish, according to the data at our command. SYMPTOMATOLOGY. (Provers, thirty-two: male, twenty-seven ; sex not stated, but probably male, four; one woman). GENERALITIES. Feeling of agility5: inclination to move rapidly3; walked rapidly2. Sense of lightness of the body5: felt as though walking on the air2. CANNABIS INDICA. 143 Muscular power impaired9. Languid and weak feeling7: with disinclination to exertion6. A peculiar feeling throughout the body12: a sensation of warmth4; a pleasant sensation of warmth pervading the whole body3; a sensation as from an electric current3; *nervous thrills5. Sensation of tingling over whole body2. Cataleptic rigidity of general muscular system4. Pains throughout the whole body4: tensive in character2. tNervous excitability4. MIND. A feeling of intoxication4: "felt drunk"-. Illusions15: pleasant*; ridiculous4; horrible3; fantastic visions6; visions of gorgeous combinations of colors2; illusions of hear- ing5; imaginary olfaction of delicious perfumes2. Time seems prolonged12. Things seem altered in appearance10: distance seems in- creased5; things seem increased in size3, e.g., the room occu- pied seems more spacious than it really is2. Impressed with the idea of being in a different place from that really occupied4. Near sounds seem to come from a distance5. Sounds are magnified in intensity2. Common-place musical combinations are transformed into inexpressibly sweet melody2. Absurd actions4: inspired by the illusions under which the experimenter is laboring2. A mental condition in which the individual feels as though constituted of two separate existences, or of two halves (duality)6: in which one half is amused at the absurd thoughts of the other half2. *The "thrills" of haschish are expressed by all the various experimenters as follows : " Occasional starts without any visible cause, like those of electric shocks." " Thrills." " Thrills. Extremely pleasant tingling of every fibre of the body." "Thrills which ran through my nervous system." "Felt the characteristic ' thrill' produced by the drug." f Some of Dr. Pease's thirty friends had tetanic spasms; besides which poisoning case No. 1 had spasms, though the character of the spasms is not stated. 144 CANNABIS INDICA. Acute sense of the ridiculous4. * Lucid intervals in the mental aberrations2. tTalkative5: talking nonsense3. Feeling of exhilaration7. Desire to laugh4: desire strong3. Laughter12: apparently causeless7. A sense of vague uneasiness2. | Fear, without apparent cause4. Mental depression6. State of revery3. Power of thought weakened11: comprehension impaired9; concentrative power impaired6. Stupidity, mental dulness7. Will-power weakened3. Will-power destroyed4. Mental power stimulated and augmented3. Mental sensibilities intensified.2 Rapid succession of ideas8: f crowding of ideas2. Reminiscences of childhood4. Memory weakened10: temporary forgetfulness4. Unconsciousness, complete insensibility3. (Notk.—Of himself and his friends Dr. Pease reports as an invariable result of taking haschish the condition known as " clairvoyance." Was this not a simple over-stimulation of the optic nerve? Whatever it may have been, it is somewhat strange that of all the other groups of provers no one reports such a condition.) HEAD. Vertigo3. Headache6: frontal3; heavy frontal ache2. * Although this effect of the action of the drug is noted by but two provers, yet from the general character of many of the records this sudden transition to a normal state may be expected; especially is this true of those in which the condition of mental duality is observable, for in this state the partition walls between the real and the unreal are so slight that a trifling alteration of the mental attitude is sufficient to dissolve them. tSeveral of O'Shaugnessy's pupil's had also "unusual loquacity." X Some of Dr. Pease's thirty experimenters had great fear, at times, of things either real or apparent." | Several of O'Shaugnessy's pupils had crowding of vivid ideas. CANNABIS INDICA. 145 Sensation of weight in forehead2. Feeling of heaviness in in the head3. Sensation of heat in head2. Peculiar sensation passing up from the body into the head2. Sensation as though a liquid was flowing into the head5: with force3; which liquid feels as though it might be blood!. Sensation of constriction of the head3. Sensation of pendulum-like oscillation in the head2. EYES. Sensation of irritation of eyelids3. Conjunctiva congested5. Pain in the eye2. Pupils dilated4: dilated widely2. Vision indistinct3. EARS. Noises in ears10: buzzing3; singing3. Sounds appear to come from a distance3. Sounds are magni- fied in intensity2. PACE. Face red3; pale3; at first red, later pale2. MOUTH. Dryness of mouth6: with thirst2. Tongue dry2; and cleaves to roof of mouth2. THROAT. Throat feels dry6: fauces specified2. STOMACH. * Appetite increased9. tThirst7: intense5. Nausea2. Sensation of heat in epigastric region3: burning sensation2. * Several of O'Shaugnessy's experimenters report extraordinary appetite. f Among Dr. Pease's thirty provers a desire for water and a loss of appetite were noted. 146 CANNABIS INDICA. STOOL. * Thin, diarrhceic stools2. URINARY ORGANS. Urine increased in quantity2. Frequent urination3. Great desire to urinate3. Dysuria3. SEXUAL ORGANS.f RESPIRATORY ORGANS.} Respiration oppressed2. CHEST. Sensation of oppression of the chest4. HEART. Pain in praecordial region3. ||Pulsations of heart increased in frequency8: and weaker than normal4. Pulse stronger than normal*. The pulse-beat was 78, 90, 108, 140 and 160, in the re- spective provers who noted the frequency. BACK. Sensation of warmth in back2. Pains in the loins2. LIMBS. An unusual sensation in the arm4: characterized as pain2; as though from a current of electricity2. Arms feel heavy2. Heaviness of forearm2. Foot felt heavy2. * Dr. Pease reports of his thirty friends that '' a painless, yellow diarrhoea was present in every case;" and " one or two were a little constipated for a few days." Prover No. 2 was also constipated for several days. fO'Shaugnessy reports of his several experimenters: "With hardly an exception great aphrodisia existed.'' % Dr. Pease and some of his thirty friends experienced a hard, dry cough after taking cann. ind. || In several of O'Shaugnessy's experimenters the " pulse was increased in fulness and frequency." CANNABIS INDICA. 147 Extremities cold2. Pain in limbs4: acute2. Numbness in limbs5. SKIN. Cutaneous sensibility diminished6: completely absent3. *Sensation of warmth of skin of body2. Perspiratory function stimulated2. SLEEP. Sleepy7. Deep sleep4: amounting to stupor2. Dreams4: of a pleasant character3. Wakeful sleep5. CHILL. Rigor2. AMELIORATIONS. Coffee removed mental dulness2. Lemon-juice relieved mental torpidity4: enlivening the ex- perimenter2. THERAPEUTIC APPLICATION. The uses of haschish in sickness which are based upon the foregoing synthesis of symptoms, are limited to maladies origi- nating in perversions of functions of nerve centres. In the following pathological derangements, therefore, cannabis indica should be of use. Alcoholic Intoxication.—The effects of haschish are cer- tainly somewhat analogous to the acute effects of alcohol. Resulting from both individuality, there is mental excitement and a general confusion of ideas, absurd actions, weakened will-power, loquacity, silly laughter, and finally, stupidity and even complete insensibility. Delirium Tremens.—When the alcohol habit is confirmed and the delirium of chronic alcoholismus supervenes, the drug * In his experiments with several pupils, O'Shaugnessy reports that "sur- face of body glowed;" but whether this is objective or subjective is not stated. 148 CANNABIS INDICA. is still strongly indicated. There is great nervous excitability, the will-power is weakened or gone, muscular power is impaired, hallucinations occur, and mental depression with a sense of fear may exist. There is headache and vertigo, with dilated pupils and indistinct vision; mouth, tongue, and throat dry, with thirst; nausea, and the general feeling of intoxication ex- perienced by the victim of delirium tremens. The vivid hallucinations of the sufferer should call especial attention to the hemp of India. Mania.—Cannabis indica is indicated in insanity with illu- sions of various kinds. Especially is the correct appreciation of time and space affected; a few seconds are prolonged into hours, days, or an indefinite number of years, and near objects seem removed to infinite distance; near sounds also appear to come from a distance. A sense of duality is experienced, the patient imagining himself to be two separate individuals. During the apparent prolongation of time, the brain is crowded with rapidly succeeding ideas, and in this state the patient imagines himself to have passed through the most varied experiences, and naturally his conversation and actions are inspired by his illusions. Reaction may take place, and mental depression succeed, with causeless fear; or a state of re very is developed ; but of whatever character the mania there are from time to time lucid intervals. x\nother fact to be remembered is that the pathogenesis shows no indication of a coarse or malicious tendency in the mental aberration. The delirium of cann. ind. is apparently dependent upon a derangement of the refined and higher mental qualities, e. g., the poetic and the artistic. That form of estacy following religious excitement, may also find its similimum in this drug. In the delirium of fevers haschish may be studied. Especi- ally is it suggested when the sense of duality is experienced, which is sometimes present in typhoid fever. In the cerebral form of this disease the drug should always be studied. CANNABIS INDICA. 149 Catalepsy.—Catalepsy has been produced by Indian hemp, and relief may therefore be expected from the plant when this peculiar neurosis is manifested. Neuralgia.—Nerve pains occur throughout the whole body, and there is a sensation as though an electric current pervaded the body ; there is also a general tingling. In addition a nervous excitability is present, which further indicates involvement of the nervous system. The neuralgic pains are reported as tensive in character. Headache.—Indian hemp produces a heavy frontal headache, with a sensation of weight in forehead. The blood seems to be forcibly impelled into the head, which naturally produces a sensation of constriction. Accompanying may be a sensation of pendulum-like oscillations in the head, and vertigo will be a prominent concomitant. Vertigo.—Vertigo from over-stimulation of the intellect may be inferred as a legitimate indication for the drug. Paralysis.—The tingling, and sensations as from an electric current throughout the whole body, with nervous thrills, im- pairment of muscular power, and pains and numbness of the limbs, all point to inpending or even partial paralysis. If, together with these symptoms, we find the patient labor- ing under various illusions, the condition known as paralysis of the insane is progressing, and the hemp will still be indi- cated. Cannabis indica has been suggested in the treatment of Mor- bus Brightii, in the treatment of general anaesthesia, and in catarrhalis senilis; but the foregoing symptomatology does not justify its use in these affections. However, as with all other drugs, so a study of this synthesis of symptoms will dis- cover indications for the drug in other pathological conditions than those here noted. i5o CANTHARIS VESICATORIA. CANTHARIS VESICATORIA. REMARKS ON PROVINGS. All the records of the Cyclopaedia of Drug Pathogenesy have been utilized, except those portions which describe the local effects of applications. Nine provings are presented, no reference being made to the strength of drug used, except in two cases, one grain of the powder, and 3d dil., respectively. Of the twenty-four records of poisoning cases (including four observations of the constitutional effects of topical applications), four resulted in death, produced by one ounce of tincture in one instance, two drams of the powder in two, an indefinite quantity of tincture in the fourth. Of the remainder, where designated, one took an overdose of tincture, the others eight grains of the powder. GENERAL SPHERE OF ACTION. Cantharis is characterized by the intensity of its effects wherever it exerts its action, which progresses steadily from ir- ritation toward destruction of tissue. The sensorium sustains a marked degree of the impression it produces upon the organism, but its most signal effects are pre- sented throughout the urinary tract, strongly supporting the well known repute of the drug in that region. Mucous membranes in general are subject to its influence, which extends through the digestive and respiratory regions. The skin is likewise attacked, though it would seem that the most pronounced symptoms here are mainly due to local action. CANTHARIS VESICATORIA. 151 SYMPTOMATOLOGY. (Provings, 33 : sex unstated, 30; females, 3.) GENERALITIES. Prostration12. Restlessness10. Convulsions2; convulsive movements2. MIND. Loss of consciousness3. Anxiety5; irritability3; moroseness2. Alarm2; excited mood2. Mental exhaustion2. HEAD. Confusion of head4; vertigo8. Pain in head10; in forehead4. Pressure in vertex2. Vessels of brain gorged with blood'. EYES. Lachrymation4; dimness of vision5. Burning in eyes3; objects appear yellow2. Painfullness of lids2; twitching of lids2. EARS. Noises in ears2. NOSE. Inflammation of nose externally3. Mucous membrane of nose sore2. Disagreeable smell2. FACE. Face sunken and pale3; hot3; red4; oedematous2. 152 CANTHARIS VESICATORIA. MOUTH. Burning in mouth6; salivation5. Blisters on tongue2; on gum2. Unnatural taste5. THROAT. Burning in throat9; constriction6. Throat painful4; dry4. Dysphagia3. STOMACH. Thirst8: excessive7. Nausea11. Vomiting7: with retching3. Eructations5; loss of appetite4. Pain in stomach9: cutting2. Burning in stomach3; distention3. ABDOMEN. Abdomen distended8. Pain in abdomen8: cutting2, burning2. Colic3; pain about umbilicus2. STOOL AND ANUS. Loose stools4; slimy2; bloody2. Tenesmus3; discharge of flatus3. Painful efforts at defecation2. Pain in auns2; itching2. URINARY ORGANS. Urging to urinate12: constant4; urine passes by drops2. Frequent micturition3: attended with pain2, Burning during micturition2. Suppression of urine4; retention3. Strangury5; dysuria4. Urine passes involuntarily2. Urine scanty4; copious2. A few drops of blood pass instead of urine2. CANTHARIS VESICATORIA. Urine bloody4, dark3, reddish2, albuminous3. Pain in renal region4; kidneys congested3. Pain in bladder3; bladder congested3. Pain in pubic region2. Ureters congested3. MALE ORGANS. Stitches in urethra2; distress while urinating2. Sore pain in urethra2; swollen internally2. Burning in urethra3; orifice inflamed3. Penis painful4; swollen2. Gonorrhoeal discharge from urethra2. Pain in spermatic cord2. Priapism5: constant2; emissions3. FEMALE ORGANS. Irritation of external genitals3: burning2. RESPIRATORY ORGANS. Cough3; hoarseness2. Difficult breathing3; respiration hurried2. Pain in chest3; tearing in scapula2. Stitches in chest3: right side2. HEART AND PULSE. Pain in cardiac region2; violent palpitation2. Pulse accelerated10. NECK AND BACK. Pain in sacrum3; in renal region2; in back2. LIMBS. Pains in limbs4; in knees3; in hands2. Weakness of limbs3. Extremities cold2. SKIN. Itching on skin3. 154 CANTHARIS VESICATORIA. SLEEP. Disturbed sleep5; sleeplessness4. Unpleasant dreams3. CHILL. FEVER. SWEAT. Chilliness3; heat of whole body2; profuse perspiration3. Febrile symptoms5. AGGRAVATION. Headache worse from motion2. AMELIOR A.TION. Urinary distress better from drinking copiously2. THERAPEUTIC APPLICATION. In accordance with the foregoing symptomatology we may ex- pect cantharis to prove serviceable in the following conditions: Mania.—Restlessness, irritability, excited mood, unnatural sexual instinct, frequent micturition. Hydrophobia.—Convulsions, salivation, burning and pain in mouth and throat, with constriction of the latter, excessive thirst, difficulty of swallowing, priapism, strangury and irrita- tion of genitals. Affections of Conjunctiva.—Burning in eyes, lachrymation, dimness of vision. Erysipelas of Face.—Nose inflamed, face hot, red and swollen. Angina Fancium.—Burning, pain and dryness in throat, with sense of constriction, and inability to swallow. Study the drug in diphtheria. Pleurisy.—Stitches in right side of chest, hurried respira- tion, cough with hoarseness. Peritonitis.—Fever; sunken face, cutting, burning pain in abdomen, with distention. Dysentery.—Cutting and burning in abdomen, about um- CANTHARIS VESICATORIA. 155 bilicus; slimy, bloody stools, with tenesmus of rectum and bladder, pain in anus. Nephritis.—Pain in renal region, urging to urinate, with pain in penis, only a few drops of blood, or bloody urine passed at each effort. Bright's Disease in early stage: with above symptoms, urine albuminous, passing to suppression and uraemia. Cystitis.—Burning at neck of bladder, pain in pubic region, dysuria, slight discharge of high-colored urine, with pain along urethra. Renal Calculi.—Great pain in kidney, extending along ureters to bladder and penis, scanty discharge of bloody urine, nausea and vomiting. Gonorrhoea, especially when it invades the region of the bladder, with burning in the neck of that organ, tenesmus, a few drops of blood, or high-colored urine discharged, pain and burning in urethra, extending to orifice, constant priapism. Spermatorrhoea.—Emissions, with the usual urinary symp- toms. Pruritus Vulvae.—Burning and itching in vulva, with dysuria. 156 CARBONEUM SULPHURATUM. CARBONEUM SULPHURATUM. REMARKS ON PROVINGS. The symptomatology of carboneum sulphuratum has been extracted from the twenty-seven records of supposed effects of the drug, which are recorded in the Cyclopaedia of Drug Pathogenesy. Of these records it was found necessary to omit fourteen (one of which is a proving, and the remainder poisonings) for the fol- lowing reasons: Proving record No. 6, because it is a clinical report; of the poisoning cases, record No. 2, because it is a generalization of supposed effects of the drug upon a number of persons; No. 4, because it is a statement of effects of the sul- phide and not of the disulphide of carbon; record No. 5, be- cause it :s a generalization; No. 6, because it is a report of mixed effects of the vapor of chloride of sulphur with that of the disulphide of carbon; and Nos. 7 and 8, because they are also reports of mixed effects. Poisonings Nos. 11, 12, 13, 14, 15 and 16 have also been omitted, because while they may be records of effects of the drug, yet there is a possibility of other factors having entered the problem. We would, however, call attention to the eye symptoms and conditions of these cases. Besides these omitted records, it has been necessary to reject parts of three proving records, for sufficient reasons, viz.: from No. 4, all the intestinal tract details, because the experimenter was subject to attacks of diarrhoea; from No. 5, all neuralgic symptoms, because the experimenter was subject to odontalgia; from No. 8, all abdominal symptoms, because they were not un- usual to the prover. The drug was tested in various preparations from the crude substance to the 4th dilution, two ounces of the crude drug be- ing swallowed by one of the cases recorded among the poison- ings, but without fatal effect; another poisoning case, which CARBONEUM SULPHURATUM. 157 we have utilized, was exposed for half a day to the vapors of the drug, and also escaped death. In all of the fourteen records of effects, which have been used in preparing this symptomatology, eleven are from males, two from females and one from a probable male, but whose sex was not stated. GENERAL SPHERE OF ACTION. From the records of supposed effects of carboneum sulphur- atum we can extract no very characteristic indications for the use of this drug. Bisulphide of carbon, however, is so com- paratively little used and so much resembles some other of the anaesthetics in its volatility, that we are not surprised at this dearth of dynamic effects. Its local action upon the mucous membranes is irritating; in fact, our records show its influence upon these tissues to be the most prominent of the effects of this sulphide. The eyes, nose, respiratory tract, and especially the alimentary canal, suffer. It is difficult to say how much of this effect is due to the local action of the substance and how much is due to the general systemic disturbance; but it is quite certain that the mucous membrane does manifest more or less disturbance wherever in contact with the disulphide. The muscular system shows its perturbation in positive painfullness generally throughout the body. The circulation is modified, a quickened pulse indicating this fact; and the cutaneous function shows disturbance, in the appearance of an eruption. Mentally, there is an irritability, with effort in thinking, and even in sleep the mental equilibrium is not restored, as may be observed in the many dreams with which the experimenters were afflicted. The indications of the action of the disulphide of carbon upon the general nervous system in producing convulsions, paralysis, etc., which have been observed in the lower animals, are not present in the records we have used. 12 158 CARBONEUM SULPHURATUM. From these observations, based upon the data at command, we must conclude that carboneum sulphuratum acts most prominently upon the mucous membranes. SYMPTOMATOLOGY. (Provers, fourteen : male, eleven; female, two ; sex not stated, but probably male, one.) GENERALITIES. Restlessness2. Malaise2. Weariness5. General pains throughout boby2. Sanguineous excitement2. MIND. Cross humor2. Thinking requires effort2. HEAD. Vertigo5. Confusion of head8. Pain in head10: frontal6 (violent3, pressive4, slight3); in tem- ple5 (pressive2, drawing2, tearing sensation2, pain beginning in forehead and extending to temple2, pressure in temples2); in parietal bone2. EYES. Pressure in eyes2; on eyes2. Pain in eye2. Irritation of eyelids3: pustule formed on eyelid2; yellow dis- charge from eye2. Lachrymation2. Pupils dilated2. Cloudy vision3. EARS. Tinnitus aurium3. NOSE. Nose stopped up2. Sneezing2. CARBONEUM SULPHURATUM. 159 FACE. Herpetic eruption on face2. Increased warmth of face3. MOUTH. Sensation of burning of lip2. Toothache in molars of right side2. Tongue furred2. Sensation of burning on tongue5: like pep- per2. Increased secretion of saliva4: with nausea2. Sense of taste perverted7: bitter2; sour2; metallic2; pappy2. THROAT. Irritation of throat6: causing cough3; scraping sensation3; scraping, rough feeling2; hawking2; pain in throat2. Irritation of fauces5: burning3; scraping2. Burning sensation in oesophagus5. (These throat symptoms are probably local effects.) STOMACH. Unimpaired appetite3; diminished appetite2. Eructations7: disgusting in taste2; of gas4; acrid2; with nausea2. Nausea5: with flow of saliva2. Inclination to vomit4. Pressure in stomach6. Sensation of warmth in stomach6: amounting to burning5. Pain in stomach4. Sensation of ful- ness in gastric region3. ABDOMEN. Pain in umbilical region2. Shooting pain in hypogastrium2; pain on pressure2. Sensation in bowels of coming diarrhoea2. Pain in abdomen7: griping2. Flatulence in abdomen6: rumbling in abdomen5. Abdomen distended3. RECTUM AND ANUS. Stitches in rectum2. i6o CARBONEUM SULPHURATUM. STOOL. Diarrhoea2. Stool soft3: pappy2. Stool thin3: watery2; scanty2; mucous2. Urging to stool4: hurried call to stool2. Discharge of flatus6. SEXUAL ORGANS. Pain in left testicle2. RESPIRATORY ORGANS. Hoarseness4. Cough4: severe cough2. Irritation to cough2. Quickened respiration2. Breathing laborious3: "dyspnoea2." CHEST. Discomfort in region of sternum3: pressure2; pain under sternum2. Shooting in side of chest2. HEART AND PULSE. Rapid pulse5. Increased strength of pulse2. NECK AND BACK. Pain in right sterno-cleido-mastoideus muscle2; in lumbar region2; in sacrum2. LIMBS. Pain in shoulder3 (right shoulder); in arm3; in forearm3; (sudden in character2); in wrist3; in thigh4 (jerking-shooting in character2) in knee4 (transient2); in foot3 (in joints of foot2, in heel2). Arm went to sleep2. SKIN. Elevated, red, sore, itching eruption on skin2. Itching of skin3. CARBONEUM SULPHURATUM. 161 SLEEP. DREAMS. Sleepy7: during latter part of day3. Disturbed sleep6: dreamful sleep5 (disagreeable dreams2); restless sleep4. CHILL. FEVER. SWEAT. Chills2. Coldness of feet2. Increased warmth of body3. AGGRAVATIONS. Pains aggravated by movement4: headache2. Abdominal symptoms aggravated by pressure3. THERAPEUTIC APPLICATION. There is probably no drug in the materia medica of which, in proportion to the size of its pathogenesy, so little therapeutic use is made. In his work on Pharmacodynamics, Dr. Hughes mentions specifically but one pathological condition in which the drug has been successfully employed, and that is in tinnitus aurium. For this use, as Dr. Hughes remarks, we have patho- genetic authority. There are, however, other morbid condi- tions in which carboneum sulphuratum may be studied, and wherein it may be found homoeopathic, among which may be noted the following: Headache.—The headache to which this substance is proba- bly best suited, is that pain caused by gastric disturbance. This is a fair inference, from the fact that the ache is generally located in the frontal or in the temporal region. The ache is of the dull kind, the patient usually having a pressive, drawing, or tearing sensation. Accompanying this there may be con- fusion of the head, and vertigo. Indigestion.—In acute indigestion carboneum sulphuratum may prove specific. The indications herein are comparatively numerous: eructation, especially of gas, with nausea and incli- 162 CARBONEUM SULPHURATUM. nation to vomit, accompanied by a sensation of fulness in the gastric region, pressure and positive pain in the stomach, be- sides a sensation of burning on the tongue, which is furred, salivation, perverted taste, present a picture of the condition in which the drug is indicated. Diarrhoea.—If in addition to the foregoing there are ab- dominal pains, flatulence and rumbling, with urging and hurried call to stool, which is pappy, thin, watery, scanty, or mucous, with discharge of flatus, and accompanying stitches in the rectum, the disulphide of carbon should be prescribed. Catarrah of the Respiratory Mucous Membrane.—Hoarse- ness is here present, cough, quickened respiration, labored breathing, pressure or pain under the sternum, shooting inside of chest, with rapid pulse and possibly chills. Such symptoms would lead us to think of the presence of bronchitis, laryn- gitis, or inflammation at some point in the respiratory tract. Myalgia.—In myalgia we have authority for prescribing the drug. The symptoms indicative, are, pains in various muscles of the body from the neck to the extremities of the limbs, the joints appearing strongly affected. The pains are aggravated by movement. From the pains in the lumbar region we should think of the disulphide in lumbago. Hordeolum.—From the irritation of the eyelids attributable to this drug, hordeolum may be successfully treated by it. Urticaria.—The elevated, red, sore, itching eruption is here indicative. CARBO VEGETABILIS. 163 CARBO VEGETABILIS. REMARKS ON PROVINGS. There is a proving of carbo vegetabilis reported in Vol. V of the Amer. Jour, of Horn. Mat. Med. (New Series), and recorded by Dr. T. F. Allen in the Supplement to his Encyclopaedia. This proving is by Mrs. Dr. J. L. C, who ingested quite a large quantity of crude charcoal; but unfortunately for the value of the record the drug was taken for "heartburn," and to "sweeten the stomach," and it is impossible to separate the primary pathological symptoms from the subsequent patho- genetic ones. This record has of necessity been excluded in toto. The provings utilized in preparing this symptomatology are those reported by Dr. Conrad Wesselhoeft in the Trans, of the Amer. Inst, of Horn, for 1877. The pathogenesis of carbo vegetabilis as found recorded in the Cyclopaedia of Drug Pathogenesy is drawn from this source. The records of all the provers have been considered, except one, that of Mrs. M. D. Crane. This is rejected because, in ef- fect, the symptoms are clinical: the cough and frequent urina- tion which annoyed her before beginning the proving, were re- ported as improved from the use of the drug. The remaining nineteen provers whose records are used, mention having taken carbo veg. in the first, second or third triturations, with the ex- ception of Wm. Owens, Jr. He does not state the degree of his trituration, but from the fact that the others all used either the first, second or third, it is probable that he also proved one of these triturations. Of these nineteen pharmacometers, as will be seen, five only submitted health records: R. R. Trotter, Mrs. Stanford, Mrs. Marshall, Mrs. Cobb and Miss Mason. These health records 164 CARBO VEGETABILIS. were obtained by giving the provers saccharum lactis, and hence their pathogeneses are of great importance. The ex- perimenters supposed themselves under drug influence during the sac. lac. test, and hence, from their subsequent records of the supposed symptoms of carbo veg., it is possible to eliminate the bulk of adventitious details, giving as a residuum a few strong probabilities. The quality of the symptoms of this group of five provers, is incomparably better than that of the remaining fourteen, but as these alone do not furnish sufficient details from which to form a significant symptomatology, it is necessary to utilize the whole set of nineteen records, trusting to the elimination feature of our method to exclude the spurious symptoms and leave untouched the real ones. It is to be regretted that Dr. Wesselhoeft was disappointed in his effort to have a primary sac. lac. proving (or health record) by all his provers of carbo veg., but as he states, it was impossible to accomplish the task, and as a result we must be satisfied with this little leaven in our lump of charcoal, until a fuller and more scientific proving of this drug has been made. GENERAL SPHERE OF ACTION. So far as it is possible to draw a conclusion from the charac- ter and number of those provings of carbo vegetabilis, its sphere seems to lie chiefly in the digestive apparatus, and to a limited extent in the respiratory mucous membrane; these systems be- ing affected through the depressing influence of the drug upon the vegetative nervous centers. SYMPTOMATOLOGY. (Provers, nineteen : men, fourteen; women, five.) GENERALITIES. A general relaxed feeling6: expressed as weakness2, languor2, fatigue2. CARBO VEGETABILIS. I65 MIND. Mental depression2. HEAD. Vertigo2. Headache10: the pain is acute7; *dull5; frontal3; in side of head9 (both sides3); temporal region" (of the left side3); parietal region3 (of the left side3); occipital region3. Throbbing sensation in temporal region2. Scalp sensitive2. EYES. Eyes weak, with inclination to keep them closed2. Pain in the right eye2. NOSE. Discharge of mucus from the nose2. Sneezing2. MOUTH AND TONGUE. Irritable condition of mucous membrane of lips, with ten- dency to ulceration2. Tongue furred2. Disagreeable taste in the mouth3. THROAT. Throat feels sore5. Expectoration of mucus from throat3. STOMACH. Appetite diminished2. Thirst2. Eructations4: which are sour and bitter2. Nausea3. A faint feeling in the stomach2. Uneasy sensation in stom- ach4: as though containing some foreign substance2. The stomach is painful2. *Four of the latter are also included among the seven who had '' acute '' pain, experiencing sometimes dull and sometimes acute headache. 166 CARBO VEGETABILIS. ABDOMEN. Sensation of fulness in the abdomen2. Flatulence3. The abdomen is painful3; tender2; sore2. STOOL. Constipation5 (slight in two provers). Diarrhoea3 (none of whom had constipation). URINARY ORGANS. Urine increased in quantity4; of a light color3; passed fre- quently3. Urgent desire to micturate'. Urine scanty and dark2. RESPIRATORY ORGANS. Irritability of the mucous membrane of the respiratory organs2. Cough3: with expectoration of mucus2. NECK AND BACK. The cervical muscles are painful2; sore to the touch2. Pain in the lumbar region3: sharp in character2. There are uneasy sensations in the sacral region2. LIMBS. Legs and arms are inclined to "go to sleep2." Hands and feet cold3. Feet cold4; damp3. SLEEP. Restless at night2. Wakeful at night3. Sleepy during the afternoon4. CHILL AND FEVER. Chilly sensation3. Sensation of increased heat of body3. AGGRAVATION. Headache is worse on motion2. CARBO VEGETABILIS. 167 THERAPEUTIC APPLICATION. General Debility.—A general debilitated state of the system is characteristic of carbo vegetabilis, due to its probable action upon the nervous system. In this condition the circulation will be more or less dis- turbed and rendered less active than normal; in consequence, the hands and feet will be cold, the latter may also be damp. With this relaxation, there may be mental depression, the di- gestion ma}' be impaired, and other concomitants, such as con- stipation, headache, etc., should be expected. Frequently micturition of large quantities of light colored urine will further suggest the drug. Respiratory Mucous Membrane.—In acute catarrh of the pharynx, larynx, trachea, and even bronchi, carbo veg. may be of service. The throat feels sore and irritable, causing cough with expectoration of mucus. This sore feeling extends to the larynx, or even to the trachea. Though there is no patho- genetic authority for hoarseness, yet from these symptoms it may be inferred as a concomitant. In an acute "cold" with chilliness followed by pain and soreness of the posterior cervical muscles and back, with the foregoing symptoms, vegetable charcoal should be a good remedy; and if the urine be dark and scanty, it will be even better indicated. Gastric Derangements.—According to our pathogenesis, carbo veg. is indicated in flatulent indigestion, wherein the patient becomes nauseated and has sour, bitter eructations. The bowels become irregular, being usually constipated, or in some cases inclined to diarrhoea. The gastric irritation also ex- tends to the fauces, the tongue becomes coated and there is a solution of continuity of the mucous membrane of the buccal cavity. As may be expected, the appetite is poor. In the general abdomen there is a sense of abnormal fulness, which is proved to be real by the gaseous eructations. The abdomen is also painful, and sensitive to touch. 168 CARBO VEGETABILIS. From interference in the digestive functions the circulation may become disturbed, a general uncomfortable feeling of de- bility experienced and also the concomitant, restless sleep. Following this general systemic derangement we may expect an interference in the excretory function of the kidneys, and as with the alimentary dejections so we here find the flow of urine either too scanty or too profuse. Another concomitant is headache, but there is no special characteristic pain, unless we consider the predominant acute pains as such, and either the frontal, sincipital, occipital, parietal, or temporal regions may be affected ; though the "side" of the head is most frequently painful. We are not prepared to say that the headache of carbo veg. may not sometimes arise from other causes than gastric irritation, but however that may be, the drug should always be studied where there is persistent headache from this cause. There are other pathological phases in which carbo vegetab- ilis is recommended by many writers and practitioners, but with our pathogenesis of the drug it is difficult to prove its homceopathicity to either the pathology or the pathological manifestations of many of the affections for which it is said to be efficacious: among which may be mentioned asthma, phthisis pulmonalis, chlorosis, haemorrhoids, glandular dis- eases, intermittent fever and eczema. With our meagre prov- ings, we are not prepared to deny that carbo veg. may be ho- moeopathic to all these derangements, but certainly we are not prepared to say that it is homoeopathic to them. CHAMOMILLA. 169 CHAMOMILLA. REMARKS ON PROVINGS. Despite the one thousand four hundred and forty-six symp- toms collected by Allen, a meagre result is obtained from a synthesis of chamomilla, based upon the Cyclopaedia of Drug Pathogenesy, the omission of Hahnemann's record alone reduc- ing it one half. The available provings are seven, most of which are short, together with four cases of poisoning. Proving No. 1 consists of a summary of constant effects appearing in five persons from taking the extract in from two to twenty-four grain doses daily, and is utilized as but one proving. No. 2, by Dr. Schueller, one of the above, has symptoms given in detail; which symptoms have been eliminated from the above-mentioned summary. No. 6 is by Reidhar, a student, who is described as "rather dyspeptic, tongue always white, subject to headache and pain in stomach, but is, on the whole, in good health." His symp- toms of head and digestive organs are omitted. Poisonings No. 2 and No. 5 are wholly omitted. A case of excessive drowsiness in an adult, from drinking chamomile tea as a beverage is included in the Symptom- atology, having been reported on good authority. GENERAL SPHERE OF ACTION. The pathogenetic effects of chamomilla are far from being well defined. Decidedly, the most prominent and important action of the drug is upon the nervous system, both sensory and motor, causing an increased "susceptibility to morbid impressions and giving rise to general exhaustion and pros- tration." 170 CHAMOMILLA. The leading features developed in the provings are a con- dition of peevishness and ill-humor; a tendency to congestion of the head, with heat of head and face; some evidences of irritation of the digestive tract as evinced by nausea, a feeling of distention of the stomach and bowels, and griping with emission of flatus; stitching or drawing pains in various parts of the body; and a general feeling of weariness and fatigue. Farther than this, experiments have not been pushed in man; but in frogs it has been satisfactorily proved that chamo- milla lessens reflex excitability in a remarkable degree. In fact, it has been demonstrated by Grisar, "that an animal forti- fied with a dose of chamomilla oil is not capable of being tetanized by a dose of strychnia which throws an unprotected frog of similar size into characteristic spasm." SYMPTOMATOLOGY. (Number of provers, eleven: men, five; women, two; chil- dren, three; uncertain, one.) GENERALITIES. Pains in various parts of the body5: drawing3, stitching3, shooting2, tearing2, pressing2, pricking2. Weariness, feeling of fatigue4. MIND. Anxiety and restlessness2. Peevish, ill-humored5. Low-spirited2. Indisposed to mental work2. HEAD. Confusion of head2. Vertigo2. Tendency to congestion of head2. Feeling of weight in head2. Pain in head4: frontal2, temporal2. CHAMOMILLA. 171 EYES. Momentary dimness of vision2. EARS. Roaring in ears2. NOSE. Crawling in nose as in the beginning of coryza2. FACE. Sensation of heat in face4: cheeks red3. MOUTH. Toothache3, (described as tearing, boring or digging). Teeth very sensitive to touch2. Tongue furred2. Abnormal sense of taste3: bitter2. STOMACH. Increased thirst2. Frequent eructations2. Nausea4: inclination to vomit3. Uneasy sensations in region of stomach3, (expressed |as rum- bling, oppression, feeling of distension). ABDOMEN. Rumbling and griping in bowels as if diarrhoea would come on2. Griping pains in abdomen*: relieved by discharge of flatus2. STOOL. Loose stools2. Tendency to constipation4. RESPIRATORY ORGANS. Inclination to cough from irritation in the trachea2. CHEST. Oppression of chest2. Transient stitches in chest3. 172 CHAMOMILLA. HEART AND PULSE. Stitches in cardiac region2. Slight palpitation2. BACK. Pains in back3: and sacrum2; shooting2. LIMBS. Arms go to sleep3; legs go to sleep2. Pains in joints and limbs5: upper4, lower5; drawing4, shoot- ing4. Feeling of weakness and weariness of lower limbs3. SLEEP. Drowsiness3; yawning2. Restless sleep3. CHILL. FEVER. SWEAT. Coldness3; shuddering2. Sensation of heat in face4. Sensation of increased heat of body4. Perspiration increased4: profuse2. Coldness, followed by heat and sweat2. AGGRAVATION. Pains usually worse at rest2. AMELIORATION. Griping in abdomen relieved by discharge of flatus2. THERAPEUTIC APPLICATION. The more prominent of the persistent symptoms appearing in the provings of chamomilla, are the pains in various parts. These in the head and teeth seem to be purely neuralgic in character. With the toothache, the teeth are very sensitive to touch; and the headache and pain in the head is frequently accompanied by heat of the face. CHAMOMILLA. 173 The pains in various parts of the limbs and body partake more of a rheumatoid nature, being often pressing, drawing or tearing, though at times stitching or shooting. They are fre- quently accompanied by a sensation of numbness, a feeling of general weariness and fatigue, and weakness of the lower limbs. The pains are usually worse at rest, and may be at- tended with considerable restlessness and ill-humor. This condition of restlessness, peevishness and irascibility, accompanied by pains in the alveoli, with heat and redness of the face, suggest the remedy in disorders incident to the teeth- ing of children, where it probably acts by quieting the reflex irritability. This quality of the drug to lessen reflex excitability, as brought out in experiments on animals, should suggest its use in various similar conditions, it possibly even being of value in that dread disease, tetanus. Hahnemann's recommendation of chamomilla in "bilious fever" is well founded in the provings. He says: "The (sometimes dangerous) disorder, resembling an acute 'bilious fever,' which is often brought on by violent, angry vexation, with heat of the face, insatiable thirst, bilious taste, tendency to vomit, anxieties, restlessness, etc., has so much homoeopathic similarity to the symptoms of chamomilla that it can hardly fail to remove the whole sickness speedily and specifically." It may also be of value in jaundice from such causes, though there is not sufficient evidence of a primary action upon the liver. Chamomilla should also be remembered in indigestion and flatulent colic, with nausea, a feeling of distention of the stomach, rumbling and griping in the abdomen as if diarrhoea would come on; all symptoms being relieved by belching or the emission of flatus. 13 i74 CHELIDONIUM MAJUS. OHELIDONIUM MAJUS. REMARKS ON PROVINGS. The following condensation of the provings of chelidonium majus has been prepared from the original provings as recorded in the Cyclopoedia of Drug Pathogenesy, in all twenty-six provers. The provings of Hahnemann have been omitted for the same reason given in other symptomatologies of this series, namely, inaccuracy as to the quantity and strength of the drug taken, and absence of data generally. GENERAL SPHERE OF ACTION. The initial effects of chelidonium are those of a narcotic irritant, disturbing chiefly the digestive organs and liver, giv- ing rise to congestions, jaundice and inflammations; and a more or less serious train of symptoms denoting hepatic dis- turbance. Also symptoms of disturbance of the functions of lungs and kidneys arise. No fatal cases of poisoning have been reported, consequently the internal pathological states must be inferred from the symp- toms produced. The more remote action of chelidonium will be apparent upon the skin and muscular systems. SYMPTOMATOLOGY. (Provers, twenty-six: men, seventeen; women, eight; sex unstated, one.) GENERALITIES. Pains felt in various parts of the body4. CHELIDONIUM MAJUS. 175 Liveliness of spirits5. Languor and prostration5. MIND. Great anxiety3. HEAD. Confusion of head4. Vertigo while head was erect4. Pressive frontal and occipital headache10. Acute neuralgic pains in temples5: right3, left2. Pain over left eyebrow5: tearing2. EYES. Itching of eyes3. Lachrymation of eyes in open air3. Pain in the eyes as if the lids were forced down3. Quivering of the right upper eyelid3. EARS. Ears feel stopped up4. Ringing in both ears4. NOSE. Coryza thin and watery8: excoriating5, non-excoriating3. TEETH. Drawing pains in the teeth8. MOUTH. Taster bitter4, slimy3. Tongue coated white4. THROAT. Sore throat as from cold5. Mucus in the throat slimy and tough5. STOMACH. Nausea8. Nausea and vomiting relieved by eructations3. Eructations of air8. Oppression in the stomach worse upon pressure3. 176 CHELIDONIUM MAJUS. Stitches in stomach3; heat in stomach3. Violent pain in the scrobiculus cordis3. Appetite increased'; diminised2. ABDOMEN. Stitching pains in the region of the liver4. Cutting pains in the abdomen5. Rumbling of air in the belly3. Painful accumulation of air or flatus about the umbilicus5. ANUS AND RECTUM. Discharge of flatus5. Pressure on the rectum3. Spasmodic contraction of the anus3. Itching of the anus and rectum with sensation as if the anus was forced out, with tubercles or piles at the anus3. STOOL. Bowels loose15: dark9, light yellow3, bloody3. Stools large, thin, watery and painless9. Stools pappy3. Stools thin and small3. Stools preceded by pain in the abdomen3. URINARY ORGANS. Frequent urination, with increase in quantity14. Yellow, foaming urine5; dark green, turbid urine6. Burning pain in urethra while passing urine9. Smarting pain in the orifice of urethra3. Dull, deep-seated pain in the kidney region3. SEXUAL ORGANS. Male.—Drawing pain in the testicles and cord4. Female.—Menses too soon, increased in quantity and pain- less2. Discharge of mucus from the vagina, viscid and stains the linen yellow.2 RESPIRATORY ORGANS. Cough5: spasmodic, with pain behind the sternum*. CHELIDONIUM MAJUS. 177 Oppression of the chest14: at night only5. Deap-seated, heavy, dull pain in whole of the right chest without cough, but with embarrassed respiration.3 HEART AND PULSE. Severe anguish with palpitation of the heart3. Pulse increased in number of beats2. NECK AND BACK. Pain in the muscles of the neck9; with pressure4. Pain in the back9. Pain in and between the shoulder blades17; right10, left7. Stiffness of the neck4. LIMBS. Upper.—Pain in and beneath shoulders17: right10, left7. Lower.—Wandering pains in the lower extremities4: es- pecially in the left3, worse when at rest3. Sudden pressive pain in right knee4. Flying stitches in right leg3. Drawing pains in left leg3. Intolerable pains in the heels as if the shoes were too short3. Drawing pains and numbness of the muscles of the right hip, right hypochondrium and right knee3. SKIN. Red, indolent pimples and pustules here and there over body and face9. Jaundiced skin, especially on forehead and nose4. Itching of skin5: arms and back2; general itching3. Dryness of the skin without increased heat3. Perspiration4. CHILL AND FEVER. Chills and chilly sensations9. Circulation more rapid than usual2. AVERSIONS AND DESIRES. Aversion to movement, desire to be at rest3. i78 CHELIDONIUM MAJUS. THERAPEUTIC APPLICATION. It is evident from the foregoing record, that apart from the incidental and singular symptoms, such as toothache, wander- ing, rheumatic pains, megrim, etc., that chelidonium will be found a valuable curative agent in some specific diseases, es- pecially those of a pulmonary, gastro-hepatic and uro-poetic pathology. In bronchitis and pneumonia the especial indications for chelidonium are, the oppression of the chest especially worse at night, with violent spasmodic cough accompanied by pain be- hind the sternum; also when the trouble is situated on the right side and is complicated with an involvement of the liver. In duodenitis the symptoms calling for chelidonium are well elicited in the provings: Hepatic region sensitive to touch, griping, cutting, stitching pains, stools thin, bright yellow; urine profuse, dark yellow; icterus, pain in and beneath the shoulder blade. In acute gastric catarrh this remedy is indicated for white coated tongue, much mucus in mouth and throat, nausea re- lieved by eructations, heat, stitches and pain in the stomach, oppression in the stomach, oppression worse upon pressure; and if with these indications there also exists the characteristic duodenal and liver symptoms of the remedy it may be prescribed with great confidence. Acute hepatitis will also be well combatted with this drug after the aconite or initial stage is past, the symptoms being nearly the same as those under gastric catarrh and duodenitis. In nephritis we have dull, deep-seated pain in the lumbar region with headache and vertigo, urine profuse, turbid and red. In influenza relieved by this remedy, we have added to the usual symptoms and prodrome of the disease, the characteristic discharges of chelidonium, " thin, watery and generally mild, but at times excoriating." Pertussis.—Chelidonium is frequently indicated in whoop- CHELIDONIUM MAJUS. 179 ing-cough, when catarrhal pneumonia threatens, when there is acute or dull pain in the liver extending to the right shoulder, jaundice, deep turbid urine, stools soft or bright yellow, cough frequent, dry, violent, hollow and exhausting. i8o CHINA. CHINA. REMARKS ON PROVINGS. Of the nineteen proving and poisoning-records of cinchona found in the Cyclopaedia of Drug Pathogenesy, fourteen in all have been used; thirteen out of seventeen "provings," and one out of two "poisonings." The reports rejected are as follows: Provings Nos. i and 2 are simply notes referring to Hahne- mann's Fragmenta de Viribus. No. 15 is a record of the effects of cinchona rubrum, and No. 6 is a generalization. Of the poisonings No. 1 is refused because it is a generalization of effects produced in men who work in the bark. In this compilation we are pleased to note an experiment made by the great Doctor, Samuel Hahnemann. Including this, all the tests were made with the crude drug in either the tincture or the powdered bark; the poisoning case was the result of a strong decoction. Of the thirteen experimenters, eleven were men and two were women. GENERAL SPHERE OF ACTION. From the above-mentioned material it is possible to form only a superficial idea of the general effects of cinchona. We are able, however, to conclude that the drug deranges the sympathetic nervous system, the intestinal tract, and the cir- culation. The vegetative nervous system evidences its disturbance by excitement or anxiety, tremulousness, cold sensation and dis- turbed cardiac action. The circulatory apparatus through the nervous system, shows perversion in the palpitation. CHINA. 181 The mucus membrane of the stomach and intestines is affected, but whether from the local drug effects solely, or through the local irritation plus the nerve centres, our data do not allow us to decide. Upon the question of the affinity of cinchona for the liver and the spleen we can say nothing, and our records show but slight suggestion of its applicability to ague or diseases of malarial origin. In fine, Peruvian bark needs a scientific re- proving. SYMPTOMATOLOGY. (Provers, fourteen: men, eleven; women, two; sex un- stated, probably male, one.) GENERALITIES. Trembling2. Restlessness2. MIND. Irritation of nervous system5: sense of excitement3; anxiety2. HEAD. Head affected in some manner5: headache3. FACE. Face congested2. Cheeks red2. MOUTH. Increased salivary flow2. STOMACH. Anorexia2. Appetite good4: increased2. Thirst2. Eructations6. Nausea5. ABDOMEN. Sensation of warmth in abdomen2. Intestinal disturbance5: "colicky" pains in abdomen2; rumbling2; abdomen distended2. 182 CHINA. STOOL. Intestinal functions stimulated7: stools pappy2; diarrhceic2. Flatulent discharges3. HEART AND PULSE. Rapid action of the heart4: palpitation3. LIMBS. Cold feet2. SLEEP. Unquiet sleep3: frequent waking2. CHILL FEVER. SWEAT. Cold sensation2. Chilliness2. Sweat2. THERAPEUTIC APPLICATION. So limited is our reliable pathogenic knowledge of Peruvian bark that we shrink from suggesting its use in pathology; neither its general sphere of action nor its symptomatology furnish more than the merest outlines of hints. Debility from loss of fluids, dropsical affections, icterus, chlorosis, hemorrhages, fevers of malarial origin, rheumatic, catarrhal and neuralgic affections may all find their similimum in china, but there is no proof of this in our study of the drug. The chief symptoms gleaned point as follows: Digestive Derangements.—The drug may relieve disturb- ances of digestion when there is a sensation of warmth in the abdomen, eructations and discharges of flatus, nausea, thirst, headache, palpitation of the heart and diarrhoea. The ap- petite is, however, either unimpaired or increased. Bulimia may find a remedy in cinchona. Colic.—Pains in the abdomen with eructations and flatulent discharges suggest the drug in colic. Since cinchona has such a reputation as a remedy for inter- CHINA. 183 mittent fever, we can do no less than call attention to all the data contained in the symptomatology. Intermittent Fever.—For this malady a few indications may be found among the symptoms produced by china, viz.: A sense of nervous excitement with trembling, headache, rapid pulse, wakeful sleep, intestinal disturbance, red cheeks, nausea, but withal a good appetite; though occasionally there is anorexia. The foregoing is about all we know of the reliable patho- genetic effects of cinchona, and the therapeutice application of the drug as given is as large as our data will permit. There is probably no drug that more strongly teaches the fact that a thorough reproving of the materia medica is a necessity. 184 CHININUM SULPHURICUM. CHININUM SULPHURICUM. REMARKS ON PROVINGS. The proving records used in making the synthesis of symp- toms of chininum are derived solely from the Cyclopaedia. The records which have been omitted are as follows: The concluding four sentences of No. 8, which are in paren- thesis, are not used because the indigestion noted was probably caused by a "moderate repast of pork and vegetables;" No. 12 is excluded because the experimenter was too much diseased generally to make a satisfactory test; Nos. 20 and 21 are omitted because the boy from whom the record was taken was convalescing from rheumatic fever; and No. 24 could not be used because too many symptoms are recorded to be probable results of the few doses taken, and also because the editors of the Cyclopaedia have put the record into cautionary small type. Twenty-seven of the twenty-nine records classified as poison- ings have also been excluded, because they are either generali- zations or reports of clinical cases; or they have been omitted from other causes which render them too indefinite for use. In the records utilized we would call attention to a few points of interest, viz.: No. 14 embodies two distinct provings, which have been classed as observation "a" and observation "b." No. 18 embodies three distinct provings, observation "a," Mrs. E., observation "b," Mrs. L-, and observation "c," Mrs. S. In every case reported the crude drug was used, and the amount varied from .01 grm. to three drachms at one dose, the latter dose also being the largest aggregate amount taken by any experimenter. After making the necessary corrections and omissions there are remaining twenty-four proving records and two poisoning cases—in all twenty-six drug tests from which to construct a symptomatology. CHININUM SULPHURICUM. I«5 GENERAL SPHERE OF ACTION. In vain do we search the records of the effects of chininum sulphuricum for a uniform sequence of symptoms. In com- paratively few of the experimenters were the initiatory effects manifested in the same organ or tissue, or function of an organ. In eight provers gastric symptoms were first observed, in five provers ear symptoms, in three the urine was first affected, in three the temperature, in three the circulation, in one the nose, in one the head, in one the limbs, and in one the stools were abnormal. The majority of the comparatively large proportion of initia- tory stomach symptoms is probably due to local drug effect, as it is a fact that nearly all drugs will produce gastric disturb- ance when taken in large crude doses. Hence, we must wait for further more exhaustive provings of chininum to indicate a uniform sequence of symptoms; which sequence some students of so-called "physiological" medicine consider a desideratum. We will call attention to the additional fact that there is no evidence in the pathogenesis of this drug, of a three-stage febrile movement (chill, fever and sweat); the nearest approach to this combination being found in two provers who had "heat of the whole body followed by perspiration," and in one who had "rigor followed by heat of face." Nor is there evidence of the paroxysmal nature of any of the symptoms of chininum. As Dr. Cowperthwaite says, " the physiological action of qui- nine is not definitely settled." It is supposed, however, to act directly upon the cerebro-spinal nerve centres, but as we have no reported cases of human autopsies at hand to verify this hypothesis, and as lesions found in animals dead from the drug can not decide the point without corroborative evidence from man, the question must remain sub judice for the present. To judge from suggestive post mortem appearances in dogs, which are verified in the human symptomatology, it is through the vegetative nervous system that the sulphate of quinia chiefly exerts its influence. 186 CHININUM SULPHURICUM. Hence (exclusive of local irritation), there is more or less dis- turbance of the digestive functions, from which reflex head- ache results. The circulation is accelerated, with diminished oxidization of tissues, causing rigor, with subsequent reactive elevation of temperature. The renal function is perverted, the urinary excrement depositing abnormal precipitates. This depression of the vital force is responsible for many other disturbances, among which may be mentioned a general sense of weakness, with mental depression, anaphrodisia, etc. SYMPTOMATOLOGY. (Provers, twenty-six: men, twenty-one; women, three; one girl; sex not given, but probably male, one.) GENERALITIES. Restlessness at night2. Lassitude9: weakness8; "malaise"5; "prostration"3. Trembling4: trembling of limbs2. Unusual sensation of heat2. Feeling of intoxication2. MIND. Indisposition to mental activity3: difficulty injreflecting2. Mental depression4: "sadness," "anxiety2." Gay humor2. Delirium2. HEAD. Vertigo9: with tinnitus aurium3. Headache7: dull2; violent4; frontal ache5; temporal2; occip- ital2 ; headache with tinnitus aurium2. Sensation of congestion of the head2. Sensation of weight in head2. Beating of arteries of head2. Head feels dull2. CHININUM SULPHURICUM. 187 EYES. Eyes sunken2; red2. Pupils dilated2. Obscuration of vision3: blindness2. EARS. Tinnitus11: "roaring6;" "ringing3." Deafness4: '' transient2.'' FACE. Face pale*: earthy color of face2. Face red2. Heat of face5: in the evening2. MOUTH. Mouth dry3. Tongue coated5: yellow3 (yellow at root2); white2. THROAT. Viscid mucus in throat2. Pain in throat2. STOMACH. Appetite increased*. Hunger5: "bulimia2;" hunger without increased appetite2. Appetite decreased4. Thirst5: much thirst3. Eructations5. Nausea6. Emesis2. Sense of heat in stomach2. Feeling of drawing in stomach2. Pain in epigastrium3: cutting in character2. ABDOMEN. Pains in umbilical region2. Movements in abdomen3: as if diarrhoea would ensue, and accompanied by passage of flatus2. Distention of abdomen5. Cutting pains in bowels3: in epigastric and umbilical regions2. 188 CHININUM SULPHURICUM. Uncomfortable sensation in hepatic region3: amounting to pain2. Pain in spleen2. STOOL. Constipation3. Ineffectual desire for stool3: accompanied by emission of flatus2. Stools softer than nomal5: pappy2; liquid2; emission of flatus with stool2. Emission of flatus'. URINARY ORGANS. Urine cloudy3. Urine deposits a sediment6: of a yellow color4 (light yellow2, and orange2); like brick dust2; deposit of crystals4 (quadrangu- lar3, prismatic2, rhomboidal2, rounded2); precipitate of brownish corpuscles2. Deposit of mucus in urine3. Urine increased in quantity4. SEXUAL ORGANS. Sexual functions depressed2. RESPIRATORY ORGANS. Cough3. Respiration accelerated2. CHEST. Oppression in chest2. Acute pain in front part of chest2. HEART AND PULSE. Palpitation of the heart2. Accelerated pulse11; pulse slower than normal3; weak5; strong2. NECK AND BACK. Dorsal vertebrae sensitive to pressure3. CHININUM SULPHURICUM. 189 LIMBS. Trembling of limbs3. Extremities cold2. Weakness in feet2. SKIN. Heat of skin3. Prickings in skin followed by perspiration2. SLEEP AND DREAMS. Somnolence4. Nocturnal sleeplessness2. Sleep disturbed7: nocturnal restlessness3. CHILL. FEVER. SWEAT. Rigor and sensation of coldness3. Temperature below normal4. Temperature slightly increased2. Sensation of heat6: pervading whole body3. Sweat5. Heat of whole body followed by perspiration2. AGGRAVATIONS. Pain worse on pressure of part affected2. Pain aggravated by moving part affected2. AMELIORATION. Pain relieved by pressure on part affected2. THERAPEUTIC APPLICATION. General Debility.—In states of the system characterized by tremulous weakness, which even amounts to prostration, with mental depression, chininum is indicated. Anaemia.—Added to this state of general debility other symptoms may be present indicating impoverishment of the blood, such as a pale or earthy color of the face, vertigo, tin- nitus aurium, a weak accelerated pulse, or even palpitation and anorexia. The sexual function may also be found depressed. 14 190 CHININUM SULPHURICUM. Such symptoms indicate chininum, whether they be from loss of vital fluids, from simple spanaemia or from leucocy- thaemia. Delirium Tremens.—The mental anxiety or delirium, to- gether with vertigo, headache, a feeling of intoxication and insomnia suggest the drug in the trembling delirium of the drunkard. Headache.—The headache of quinia is most frequently located in the frontal region, though both temporal and occip- ital ache may occur. The pain is violent, and sometimes accompanied by roaring or ringing in the ears. The head feels full and dull, with sensation of weight therein and also of arterial throbbing. Violent, full, throbbing headache, therefore, with tinnitus aurium and vertigo, form a clear picture of a chininum headache. Vertigo.—Vertigo resulting from anaemia with concomitant tinnitus aurium suggests the drug. Paralysis of Special Senses.— Blindness, or partial obscuration of vision, with dilatation of the pupils, should lead to a study of quinine in amaurosis. Deafness is a prominent symptom, and tinnitus aurium is of frequent occurrence in the pathogenesis, the sounds being noted as roaring or ringing. Digestive Disturbances.—The functions of the digestive organs are disturbed, not only by the local effect of the sulphate, but also most probably through its action upon the nerve cen- tres. The mouth is dry with yellow-coated tongue, thirst is present, also hunger, which may amount to positive bulimia. A peculiar condition may supervene in which the sufferer has hunger but no increase of appetite; or, as is sometimes the case there is simple anorexia. The prominent symptoms, however, seem to be hunger, thirst, eructations, distended abdomen, and pain in epigastrium. As a result of this intestinal disturbance the bowels may be- come somewhat constipated, and an ineffectual desire for stool, with passage of flatus, may annoy the patient; or more CHININUM SULPHURICUM. 191 frequently the faecal discharges are softer than normal, some- times pappy or sometimes liquid ; but no marked characteristic of the stools of quinia is discoverable in its pathogenesis. Hepatic and Splenic Derangement accompanying malarial troubles, for which quinine is so largely dispensed, find no other pathogenic indication than an uncomfortable sensation in the hepatic region, which sometimes amounts to pain, and no other splenic symptom than simple pain. Intermittent Fever.—There are no pathogenic grounds for prescribing chininum in paroxysmal derangements; but from its well known power in intermittent fever it should be remem- bered and studied when the following symptoms are present: Rigor and sensation of coldness, with temperature below normal. Sensation of heat pervading the whole body, and slight rise of temperature followed by perspiration. Headache, vertigo, tinnitus aurium, weakness, etc., are concomitants worthy of note. During the attack the urine may deposit a sediment, sometimes mucus and sometimes lateritious, which latter, under the microscope, may prove to be quadrangular, prismatic, rhomboidal or rounded crystals. These crystals are either uric acid or some of the urates or phosphates, and should call attention to the drug when they are present in liver disease, rheumatism, gout, leucaemia, and in all febrile affections. 192 CICUTA VIROSA. CICUTA VIROSA. REMARKS ON PROVINGS. Thirty-five records are used in this pathogenesis. Of these, one is a proving of the tincture and thirty-four are the results of eating the root or a decoction of the root. Several poison- ing groups are classed as more than one proving, all the symp- toms of the group being attributed to each person affected. GENERAL SPHERE OF ACTION. Cicuta acts primarily upon the cerebro-spinal nervous system, the cerebral symptoms being the more prominent; and, as a reflex, we find more or less disturbance of the digestive tract. Contrary to its analogue, strychnia, we note that cicuta im- pairs the mental faculties, total loss of consciousness being usually an early result of poisonings. The spasmodic action of the drug is evinced in various ways, from simple grinding of the teeth or hiccough to violent con- vulsions. These conclusions are supported by post mortem examina- tions and experiments upon animals. SYMPTOMATOLOGY. (Provers, thirty-five: men, four; women, two; children, twenty-nine.) GENERALITIES. Convulsions23: '' epileptic' '9. Feeling of weakness9: with staggering2. Tetanus3. CICUTA VIROSA. 193 MIND. Unconscious20: delirious5. Stupefied4. Anxiety2. HEAD. Vertigo15. Heaviness of head2. Shooting pains in head2. EYES. Dilated pupils4: insensible to light3. Obscuration of sight2. MOUTH. Trismus8. Grinding of teeth3. Foaming at mouth2. FACE. Redness of face3. Face pale and distorted3. THROAT. Throat dry2. STOMACH. Burning in stomach3: with thirst2. Hiccough6. Nausea7. Vomiting11. Swelling in prsecordial region, which shakes diaphragm2. CHEST. Feeling of oppression in chest2. RESPIRATORY ORGANS. Respiration irregular5: with snoring and at times interrupted by hiccough3. Shallow breathing3. Breathing labored3. 194 CICUTA VIROSA. ABDOMEN. Pain in abdomen11: violent4. HEART AND PULSE. Pulse small and slow4. SKIN. Coldness of skin8. CHILL. FEVER. SWEAT. Coldness of skin8. Coldness of extremities2. THERAPEUTIC APPLICATION. Epilepsy.—From the pathogenesis of cicuta we should esteem it one of the foremost remedies in epilepsy or epilepti- form convulsions. The attacks may be preceded by anxiety, vertigo, hiccough or vomiting, closely followed by obscuration of sight and violent clonic convulsions. The convulsions may be accompanied by trismus or by grinding of the teeth and foaming at the mouth. Tetanus.—The condition of trismus obtaining in the provers, together with the other evidences of the spasmodic action of the drug, lead us to expect benefit from its exhibition in this intractable disease. Indeed several provers have experienced marked tetanus, accompanying a condition of unconsciousness. Hiccough is another spasmodic condition in which cicuta has already achieved some repute, as is also asthma. Headache.—Cicuta will give prompt relief in certain forms of "sick headache" from cerebral congestion. They are ac- companied by vertigo, obscuration of sight and nausea or vomiting. At times there may also be coldness of the skin. Cerebro-spinal Meningitis.—There is record of sixty con- secutive cases treated with cicuta alone without a death (Dr. Baker of Batavia); and while neither provings nor poisonings indicate a febrile movement, post mortems confirm the symp- CICUTA VIROSA. 195 toms pointing to cerebral hyperaemia and irritation; and we may properly place cicuta among the most valuable remedies in this dread disease. Eczema.—Although cicuta is recommended for eczema of the face, redness is the only symptom occurring in the provers. Possibly the drug was not continued sufficiently long in any prover to produce the marked pustular inflammation ascribed to it. 196 CLEMATIS ERECTA. CLEMATIS ERECTA. REMARKS ON PROVINGS. The Cyclopaedia of Drug Pathogenesy furnishes the entire record of provings from which the subjoined symptomatology is compiled. No. 1 (Hahnemann's Chronic Diseases) and No. 16 are excluded, the last experimenter being very nervous, subject to congestions of the head, vertigo, tinnitus of right ear, slight illusions of vision and hemorrhoids. The strength of drug used was the tincture, with the excep- tion of three instances, in which the first dilution was taken. GENERAL SPHERE OF ACTION. Clematis manifests its effects chiefly upon the skin, glands, urinary tract and sexual organs. The eruption produced is most marked about the head, although it may involve the entire cutaneous surface, present- ing in some cases a vesicular character. The inflammation caused is most prominent in the inguinal glands and testes. The urethral tract exhibits a condition similar to the effects of the gonorrhoeal virus. SYMPTOMATOLOGY. (Provers, twenty-one: male, seventeen; female, four.) GENERALITIES. Prostration13. General bruised feeling over the body3. CLEMATIS ERECTA. 197 MIND. Depression8; irritability7; cheerfulness3. Disinclined to mental effort6. Mental activity2. HEAD. Confusion8; vertigo5. Head feels heavy5, hot3. Pains in forehead10: pressive5. Pains in temple5: pressive2. Pains in side of head3, in occiput3. Itching on hairy scalp4, over entire head2. EYES. Indistinct vision3. Burning in eyes3; itching2. Eyes red3. EARS. Impaired hearing2. Noises in the ear3: ringing2. External ears burning hot2. NOSE. Frequent sneezing5, with watery discharge from nose2. FACE. Warmth of face5, with red cheeks2. Pain in cheeks2; in zygoma2. MOUTH. Increased secretion of saliva3. Swelling of submaxillary gland3. Mouth dry3; tongue furred4. Toothache7: jerking3, shooting2, relieved by cold water2. Uvula sensitive2. THROAT. Roughness in the throat2. 198 CLEMATIS ERECTA. STOMACH. Appetite increased6; diminished4; anorexia5. Nausea7, with vomiting2; inclination to vomit2. Thirst7; eructations4. Pressure in stomach2; tensive sensation in stomach2. ABDOMEN. Distention of abdomen5, with rumbling3. Pain in abdomen4; in splenic region3; in hepatic region2; in hypochondria2; in inguinal region6 (with swelling of inguinal glands). STOOL AND ANUS. Constipation5: with straining2. Loose stools7; discharge of much flatus3. Burning in anus2. URINARY ORGANS. Frequent desire to urinate4. Discharge of urine diminished6; increased4. Urine turbid2; pain in renal region2. Burning in urethra5. Discharge of mucus from urethra2. MALE ORGANS. Pain in spermatic cords3: right2. Pains in testicles3. Erections3; sexual excitement3. Itching in genitals2. RESPIRATORY ORGANS. Cough6; tightness of chest3. Stitches in chest3; heat2. HEART AND PULSE. Pulse accelerated7. NECK AND BACK. Pain in sacrum2; in renal region2. CLEMATIS ERECTA. 199 LIMBS. Upper.—Pains in shoulder5: left2; in elbow5; in wrist4; in arms4; in forearm2; in fingers2. Arms feel bruised and beaten'". Lower.—Pains in thighs2; in knees4 (right2). Weary, bruised feeling in thighs2. Itching on thighs3. Legs exhausted, heavy and painful3. Pains in calves3; in shins2. Heaviness of lower limbs2. In General.—Bruised feeling in the limbs3. Heaviness of the limbs3. SKIN. Itching on hairy scalp4; on various parts of the body2. Itching on forearms2. Vesicular eruption, with burning and itching2. SLEEP. Drowsiness7; restless sleep6; yawning3. AMELIORATIONS. Toothache relieved by cold water2. THERAPEUTIC APPLICATION. In all the provers cutaneous irritation, in various forms and localities, was manifested, and the inferences suggest the use of clematis in a more extended sphere than its symptom- atology would seem to warrant. In Headache, pains, chiefly pressive, are felt in forehead, temples and occiput, attended by a feeling of weight. Eczema of scalp may be expected to yield to its curative influence. Burning in the eyes, with indistinct vision, suggests its use in Iritis (probably rheumatic) as also in inflammation of the lids. 200 CLEMATIS ERECTA. The Toothache is of a jerking character, relieved by cold water, accompanied by a free discharge of saliva. Inflammation of the inguinal glands, with swelling and pain, points to its usefulness. Prominent symptoms of Gonorrhoea are: Burning in urethra, with frequent desire to urinate, turbid urine, and mucous dis- charge. Persistence of the last-named symptom would indicate its use in incipient stricture. Orchitis is within the sphere of its influence, as shown by the pains in the testicles extend- ing along the spermatic cords. In Rheumatism benefit may be expected from its use, as pains in all the limbs, and a general bruised feeling are promi- nent symptoms. COCA. 201 COCA. REMARKS ON PROVINGS. The Cyclopaedia is the source from whence the symptomatic synthesis of coca erythroxylon is drawn. Nos. 16 and 20 are the only omitted records. The former is an indefinite generalization of effects upon Peruvians; the latter is a generalization of effects upon the voice. Record No. 7 contains observations upon two individuals, and is used as two separate provings. (The record following is numbered ten, which is no doubt a mere typographical error.) In Record 17 a few generalizations are introduced from several experimenters. These have been merged together with the symptoms of Montegazza and the whole used as one record. Coca was proved with leaves, decoction, infusion, tincture, ix, 2x, and 3d dilutions. The largest recorded quantity of the drug taken during any one test is thirty-six to forty cups of infusion of leaves in twelve days; and the smallest recorded quantity during any one proving is thirty-three drops of the 2x dilution and ten drops of the ix dilution, covering a period of nine days. The largest recorded amount taken at one dose is an infusion of three ounces of leaves; and the smallest amount is five drops of the ix dilution. The longest recorded period of time consumed in any one test is twenty-one days; and the shortest time recorded is three days. Several records are indefinite, both as to amount and time, except in so far as note is made that a considerable quantity of the crude drug was consumed. The poisonings have not been used; the gen- eralizations are too broad. GENERAL SPHERE OF ACTION. Although this drug has been largely used, yet comparatively 202 COCA. little has been satisfactorily proved of its action. Like coffee, tea and other drugs of this class, coca apparently prevents rapid waste of tissue. We can find no cases of death either in man or the lower animals, and hence are compelled to draw our conclusions from the symptomatology exclusively. While coca acts upon both the great nervous systems, its effects are apparently more pronounced in the cerebro-spinal centres. This is noticed in the general mental and physical sense of well-being, in the disturbed, dreamful sleep, in the affection of the special senses, and in the inclination to unusual muscular exertion and the absence of fatigue thereafter. The results of the action of the drug upon the sympathetic nerve centres are shown in the quickened action of the heart, and in the disturbed digestive functions. We find, therefore, that coca erythroxylon chiefly affects the mind, the digestive organs, the muscular system and the circu- latory apparatus. SYMPTOMATOLOGY. (Provers, sixteen: men, twelve; women, two; girls, one; sex not given, but probably male, one.) GENERALITIES. Weariness6: in the evening3; listlessness3; weakness2. Stimulation of the nervous system6: manifested by inclina- tion to physical exercise3; increase of muscular strength2; and unusual insusceptibility to fatigue2. Sense of general comfort2. MIND. Mental buoyancy5: excitement2. Mental depression3: anxiety2. HEAD. Vertigo5: on going into open air2; with headache3; on ex- ercising2. COCA. 203 Headache9: frontal4; side4 (right side3, right temple2); pres- sive3; acute2; dull2; shooting2. Sensation of heaviness in head, "dullness of head"2. Headache relieved by open air2; relieved after eating2. EYES. Eyelids inclined to close2. Sudden visual sensations4: scintillations3. EARS. Tinnitus aurium3: "humming"2. MOUTH. Sensation of burning in mouth2. Disagreeable taste in mouth4: "bad taste"2. Coated tongue2. THROAT. Dryness in throat2. STOMACH. Hunger2. Appetite diminished7: total loss of appetite3. Increased thirst2. Eructations2. Nausea2. Sensation of fulness in stomach2. ABDOMEN. Borborygmus2. Fulness of abdomen2. Sense of fulness in epigastrium2. STOOL. Loose stool3; urging to stool3; stercoraceous smell absent from faeces2. Constipation2. Flatulent discharge2. URINARY ORGANS. Urine decreased in quantity2. 204 COCA. SEXUAL ORGANS.* CHEST. Stitches in chest2. Sense of oppression in chest2. HEART AND PULSE. Palpitation3. Pulse quickened3. SLEEP AND DREAMS. Sleepy during latter part of day3. Sleeplessness4. Disturbed sleep7: restless sleep.5 Dreams4. AMELIOR ATIONS Symptoms relieved in open air3: headache2. Headache relieved after eating2. THERAPEUTIC APPLICATION. According to the foregoing synthesis, the therapeutic field of coca is quite circumscribed. Derangements of the Nervous System.—After either mental or physical over-taxation coca may prove useful; whether from too prolonged brain work, sexual excesses, undue use of opium, alcohol or other agents causing depletion of nerve force. Such a condition will be manifested by general weakness, listless- ness, mental depression and even anxiety, poor appetite, con- stipation, headache, vertigo and palpitation of the heart. Or an opposite state of increased mental activity may be present, in which the patient suffers from insomnia, or if he sleep he will be restless and disturbed by dreams. Coca should also be studied in cases where the patient seems endowed with more energy than muscular strength. Nervous Excitement, per se, may sometimes find its simili- mum in coca, when the sufferer does not appear to lose either In two cases Montegazza observed a marked increase of sexual powers. COCA. 205 mental or physical force, although he may suffer from persist- ent insomnia. Headache.—The coca frontal headache of indigestion is relieved in the open air, and also after eating. The head feels heavy. The drug should be studied in nervous sick headaches. Vertigo may also accompany the headache; but unlike the latter, it is not relieved on going into the open air, but is pro- duced thereby. Exercise also causes the coca vertigo. Digestive Disturbances.—Coca interferes to some extent with the functions of the digestive organs. There is borboryg- mus, discharge of flatus, sensation of fulness in abdomen, urg- ing to stool and loose dejections. Other concomitants are, thirst, nausea, eructations, dull frontal headache and vertigo. Constipation is sometimes a symptom, but it has no marked features. Dyspnoea, when caused by nervous cardiac palpitation, may be relieved by coca. Cardiac Disturbance.—In palpitation resulting from inter- ference with cardiac innervation (too prolonged brain work, sexual excesses, etc.,) accompanied by a sense of oppression in chest, insomnia, mental depression, tinnitus aurium and anorexia, coca should be studied. Insomnia.— Coca produces disturbed, restless, dreamful sleep. No doubt there are many other deviations from health wherein coca is homoeopathically indicated, but like many other drugs its pathogenesis is too meagre to justify more than a few therapeutic hints. 15 2o6 COCCUS CACTI. COCCUS CACTI. REMARKS ON PROVINGS. The Cyclopaedia presents nineteen provings of coccus cacti, all of which have been used in making up the pathogenesis of this drug. No case of poisoning by cochineal appears. In this, as in some other instances, we are indebted to the Aus- trian provers for the necessary data, they having brought out the symptoms of the drug by proving it on twenty-three individuals. The drug was taken either in substance, tincture, dilutions and triturations, varying from the first to the sixth. Several of the provers ran the entire scale, from the highest point to the lowest. Sixteen of the provers were men, eleven of them being phy- sicians. Two women and a boy of fifteen years also took part. Taken altogether the proving is an excellent one, and the effects of the drug upon the system are well brought out. GENERAL SPHERE OF ACTION. Coccus cacti appears to affect chiefly the mucous membrane and the muscles. On the former it produces a series of charac- teristic symptoms, apparently by interference with the free secretion of mucus, which becomes viscid and unable to per- form its function of moistening the mucous surfaces. The mouth, tongue and upper air-passages become dry and rough; the taste pappy. The same condition is present in the larynx, trachea and bronchii, as evidenced by the dry, rough, scraping feeling, with hawking of mucus. Very prominent is a constant cough, which seems to be caused by dryness of the mucous membrane as well as by the presence of viscid mucus in the air-passages. Hoarseness and dyspnoea still further give color to this view. COCCUS CACTI. 207 That the peculiar effect of the drug upon the mucous mem- brane extends to the stomach seems evident. The gastric iuice is so altered—probably becoming viscid, like the secre- tions of the air-passages—that digestion is interfered with. That this is probably the case is evidenced by the occurrence of eructations, nausea, pain and a sense of fulness in the stomach and a feeling as if a round, heavy substance lay therein. That anorexia was experienced by some provers and about an equal number had unusual hunger does not militate against the suggested theory of the drug's action, since the anorexia would surely occur when digestion is interfered with, .and, on the other hand, if the gastric juice be so altered as to be viscid and incapable of performing its function, hunger would certainly assert itself. The bowels show some evidence of the same influence, as also do the bladder and urethra. Coccus cacti, further, has a decided effect upon the muscles and seems to reach most of them. In the muscles on the front and sides of the thorax pain is felt, especially on the left side and about the heart. The severe pain felt in the abdomen is probably also muscu- lar, located either in the muscles of the abdominal walls or in the coats of the intestines themselves. We are led to this view from the character of the pain, the increase in vermicular move- ments and from the analogy of the action of the drug upon other muscular tissue. Pain in the muscles of the back, as well as the upper and lower extremities, is marked. SYMPTOMATOLOGY. (Provers, nineteen: men, sixteen; women, two; a boy of fiteen years.) GENERALITIES. Restlessness2. Feeling of prostration5: exhaustion2. Extreme weariness3. Pains in the muscles3: drawing and tearing2. 208 COCCUS CACTI. MIND. Cheerful4: unusually2. Irritable mood4: " cross "2. HEAD. Confusion of head6. Hot feeling in the crown2. Headache11. Character of pain: pressive5 (in the temples3); shooting3 (in> the left temple2). Location of pain: frontal4; in the temple5 (left2, both temples2). EYES. Pain in the eye3. Sensation of a foreign body between the eye and the lid2. EARS. Itching in meatus externus2. Feeling as if the ears were stopped3. Violent stitches in the ear2. Drawing sensation2. NOSE. Edges of nostrils sore2. Mucous lining feels dry2. Discharge from the nose3: mucous2. Sneezing5. FACE. Redness of face2. MOUTH. Feeling of roughness in the mouth2. Dryness2. Toothache4: in right molars3; left2. Tongue dry3, and furred2. Tongue coated3: white2. Increased flow of saliva4: greatly increased3. COCCUS CACTI. 209 Taste: sweetish4 ("disagreeable, metallic, sweetish"2); bitter5 ("bitter, disgusting"4); metallic6 ("metallic, disagreeable"4, "and sweetish"2); pappy2; disgusting3 (and flat2). THROAT. Sore throat3. Burning in the throat4: in fauces2. Scraping feeling6: in fauces2. Dryness5. Feeling of roughness6. "Hawking"5: constant"; of mucus3. Sensation of constriction at the throat2. STOMACH. Appetite increased7: hunger3; ravenous3. Appetite diminished6: anorexia3; distaste for food2. Soon satiated2. Thirst3: great2. Tasteless eructations3. Nausea8: retching4. Burning sensation in the oesophagus2. Heartburn2. Sense of fulness in the stomach3, as if having eaten too much2. Pressure5. Pain in the stomach4: shooting2; "stomachache"2. Sensation of cold in the stomach2. Feeling as if a large, foreign body lay in the stomach2. Epigastrium sensitive to touch2. ABDOMEN. Feeling of warmth through the abdomen2. Pain12: griping5; cutting3; about the navel3; in left hyper- chondrium3; in the hypogastric region3. Rumbling in the abdomen4: with discharge of flatus3. RECTUM. Shooting pains in the rectum3. 210 COCCUS COCTI. STOOL. Diarrhoea5: copious2; pappy3; with griping3. Urging to stool3: often in vain2. Discharge of flatus5: with loose stools2. Constipation2. URINARY ORGANS. Pain along the course of ureter2. Feeling of pressure in the bladder2. Pain in the bladder4. Burning in the urethra while urinating2. Frequent micturition5: urging4. Urine copious2; dark colored2. SEXUAL ORGANS. Increased sexual desire5: great desire4. RESPIRATORY ORGANS. Irritation in the larynx which causes coughing6. Hoarseness9. Irritation in the trachea5. Painful sensations in the lungs3. Cough12: caused by persistent irritation in the bronchii2; short cough5; dry6; frequent5; "in short fits"4; disturbing sleep at night3; tending to produce vomiting2. Expectoration8: easy and in large amount2; viscid and cling- ing2; yellow3; greyish lumps2. Dyspnoea3. CHEST. Oppression of the chest4. Tightness2. Feeling of pressure4. Pain in the chest8. Character of pain: shooting3; burning4; pressive2; stitches on both sides4. Pain relieved by inspiration2. Location of pain: in the sternal region4; on the right side2; left side6 (cardiac region2, felt in small spot2); about the left clavicle3. COCCUS CACTI. 211 The chest, especially the scrobiculus cordis, very sensitive to touch3. HEART AND PULSE. Pulse accelerated3. Palpitation2. NECK AND BACK. Pain in the neck5: nape2; left side3. Pain in the back9: lumbar region5; near the kidneys3; in the loins2; about the sacrum6 (in both lumbar and sacral regions4). LIMBS. Exhausted feeling in the limbs2. Upper.—Pain in the arms7: in the scapula, extending to elbow2; in the shoulder5 (drawing pains3); in the elbow3; fore- arm3; fingers2. Lower.—Pain6: in the thighs4 (along the course of the large nerves and vessels2; violent stitches in the extensor muscles of the thigh like an electric spark2); in the calf of the leg2; toes5 (great toe2). SKIN. Burning feeling in the skin2. Pricking on the surface of the thigh as if from an electric current2. SLEEP. Restless sleep8. Dreams5: vivid2; amorous2. CHILL. FEVER. SWEAT. Chill2. Chilliness3. Dry heat2. Chilliness in the daytime, followed by profuse sweat towards next morning2. 212 COCCUS CACTI. THERAPEUTIC APPLICATION. It may be said, in a general way, that with the exception of headache and pains in the muscles, the diseases in which cochineal will give relief are those affecting some portion of the mucous membrane. In headache the pain is located chiefly in the temples, although felt also in the forehead, and is pressive or shooting in character. There is a hot feeling in the vertex; the head is confused. The head symptoms, although not numerous, are sharply defined, and eleven out of the nineteen provers had headache. Muscular rheumatism may be relieved by coccus cacti wherever occurring, but more particularly when it attacks the muscles of the chest and certain muscles of the neck, back, abdomen and extremities. In the chest stitches are felt on both sides or the pain may be described as burning, shooting or pressive. These sensa- tions are relieved by inspiration, differing in this from most congeners. While pain is felt in nearly all parts of the chest, the left side is affected in greatest degree, having as a centre the cardiac region. Pain is felt also more to the left and up- wards towards the clavicle. The chest becomes sensitive to touch, especially about the heart. Coccus cacti does not seem to affect the muscles on the posterior surface of the body, except the nape of the neck and those about the lumbar region and the sacrum. In the limbs the drug causes pain in nearly all of the mus- cles, especially the larger. These pains shoot from the shoul- ders toward the hands and from the hips towards the feet, appearing to follow the large vessels and nerves. In the thighs there are violent stitches in the extensor muscles, like electric sparks. After the pain there is an exhausted feeling in the limbs. It would seem that the severe abdominal pains felt are located in the muscles, and the remedy should be useful in rheumatism COCCUS CACTI. 213 of this region. The pain is cutting or griping, and is felt especially in the left hypochondrium, in the umbilical and hypogastric regions, and is accompanied by rumbling with dis- charge of flatus. Urinary Organs.—In affections of the urinary organs -coccus cacti is of use when there is pain in the loins along the course of the uterus, in the bladder and urethra, with vesicle tenesmus, the urine copious and dark. There is a burning sensation in the urethra when urinating. The remedy should be of value in nephritic colic. When affections of the respiratory tract come under con- sideration, the most remarkable action of this remedy develops. Pertussis.—Coccus cacti presents a group of symptoms bearing a close resemblance to whooping cough, and its use in this affection should cut the disease short, or at least mitigate its distressing features. The cough caused apparently by a persistent irritation in the larynx, is frequent, short, occurring in paroxysms, at times awaking the patient from sleep. There is a tendency to vomit after coughing, due probably to the adhesive character of the phlegm. The mucus coughed up is abundant, very viscid and hard to remove. In the attempt to detach it from the mouth it is drawn out into long strings, thus producing the remarkable ucharacteristic" insisted upon by Dr. Farrington and others. Shortness of breath occurs with the cough and a feeling of prostration follows. Acute diseases of the air passages exhibiting the symp- toms just related demand coccus cacti, especially when there are present sore throat with dry, rough scraping feeling; con- striction; constant "hawking" of viscid mucus; hoarseness; irritation in the trachea; painful sensations in the lungs and severe pains in the chest accompanied by oppression.. 214 COLOCYNTH. COLOCYNTH. REMARKS ON PROVINGS. Dr. Hughes mentions colocynth as a "crucial instance of the fruitful results attainable by the Hahnemannian process of 'proving' on the healthy body." "Here," he says, "is a sub- stance which traditional medicine knows simply as a purgative. The modern experimentation on animals has done nothing for it; as a purgative, and nothing else, it still stands in the works of Ringer, Wood, and even Phillips. But a few physicians in Vienna agreed to test its effects on their own bodies; and lo! a range of action is revealed which at once puts it in a high place among specific remedies." The following provings have been used in this symptoma- tology: Cases of poisoning, Nos. 6, 7, 8, 11, 12 and 16, published by J. W. Metcalf; fourteen provings of the Austrian Provers' Society; four provings of Martin's Society; one proving by Dr. J. V. Muller, and Hechenberger's Colocynthology, making a total of twenty provings and six poisonings. The provings of Dr. J. P. Wurstl, of the Vienna Society, are omitted. His three provings lose much of their positive value "from the fact that he had formerly often experienced the same symptoms— gouty-rheumatic pains, toothache, diarrhoea, etc.—as he suffered while taking colocynth." "They are a little remarkable, how- ever, from the fact that the drug proved a specific for those ail- ments, which have never since troubled him in the least." Of Martin and his provers, Metcalf says: "At least as far as their results are exhibited, they have not remarkably enlarged our knowledge of the action of colocynth. The experimenters seem to have been somewhat too apprehensive and anxious; the symptoms obtained do not bear the impress of a drug sick- COLOCYNTH. 215 ness, but look like fragmentary and purely subjective phe- nomena." Dr. Hechenberger is described as "an ardent advocate and a stout defender, but a timid prover and a weak observer." Dr. Arneth as one who "possessed as sound an understanding, as unpredjudiced a spirit of observation, as much acumen, honor- able feeling and devotion to the truth as the very best of our opponents." It is worthy of note that he could obtain no symptoms from above the fourth dilution. Dr. J. K. Bohm is described as "rather weak, small, pale, lean, subject to blenorrhoeas of all sorts, accustomed to the greatest moderation, never affected with any serious illness, but atoning for every error in diet by a violent fit of colic." But few symptoms from him are incorporated. Dr. Fleichman's susceptibility seemed to be pre-eminently shown in the bowels, "a discharge of blood from the anus oc- curring, which after more than a year still continues in more or less quantity daily." Before this proving he had never had a discharge of blood from the anus. Dr. Joseph Rothansl closes his proving with the following interesting remarks: "I took four hundred and thirty-six drops of colocynth tr. in the whole. By far the most prominent and troublesome symptom in my case was the colic, which never came on except at night. The rheumatic pains in the limbs and joints are, however, much the more important phenomena, and with greater certainty ascribable to the drug, inasmuch as I had never experienced the like, either before or since." Of the Vienna provers, twelve made provings with the tritu- ration; two females proved the third dilution; Martin's four provings were with the trituration, as also Hechenberger's ex- periments; and Dr. Mfiller proved the fourth dilution. Neither of the female provers developed any symptoms con- nected with the reproductive organs; and none of the provers have given any previous health record, though occasional remarks of interest concerning their condition of health at time of proving are appended. 2l6 COLOCYNTH. GENERAL SPHERE OF ACTION. The first effect of large and poisonous doses of colocynth is to cause nausea and vomiting, soon followed by violent grip- ing, colicky pains in the abdomen, and diarrhceic stool. Sometimes the abdomen becomes swollen and sensitive to touch; and the stools, from being feculent, become bloody, with violent tenesmus. The vomiting and-the colicky pains seem to be caused by the influence of the drug upon the solar plexus, and which may also be obtained by inunction upon the abdomen. The rectum is the only portion of the bowel found inflamed from poisonous doses; but the specific action may extend higher; and in fatal cases, traces of peritoneal inflammation have been found. From the provings, also, we find the more important action of colocynth to be upon the stomach and bowels, and upon the sensory nerves throughout the body. There is dulness of the head and a disinclination to sus- tained mental effort. These symptoms are followed by fulness of the epigastrium, with nausea and occasional vomiting, and pappy or loose stools soon occur, usually preceded by colicky pains in the region of the navel. The disturbance may even go so far as to simulate a true inflammatory condition of the lower bowel, with tormina and tenesmus, accompanied by mucous or bloody stools; or the influence extends to the peri- toneum, with great distention and sensitiveness of the abdo- men. The colic may be a part of the general rheumatic or neuralgic pains which occur throughout the body. The action upon the urinary organs is very decided, there being frequent desire to urinate, with increased flow of urine. SYMPTOMATOLOGY. (Provers, twenty-six: males, twenty-four; females, two). GENERALITIES. Transitory pains in various parts of the body3. Weariness, lassitude11. COLOCYNTH. 217 MIND. Disinclination to sustained mental effort3. HEAD. Head confused2. Headache10: violent3, pressing4, tensive2, throbbing2. Dulness of the head5: more especially in the frontal region3. Pains in the head, ranging from dull to acute6: more especi- ally in the temples4, forehead2. EYES. Painful pressure in the eyeballs4. Aching in the eyeballs2. EARS. Noises in the ears3: roaring2. FACE. Pains in various parts of the face4: orbits2; pressive3, draw- ing2. NOSE. Fluent coryza3. MOUTH. Drawing, aching pains in the teeth4: most prominently affecting those of the upper jaw3. Collection of saliva in the mouth2. THROAT. Feeling of roughness in the throat5. Dryness of the pharynx2. STOMACH Loss of appetite4; disgust for food2. Unusual thirst4. Rumbling in the stomach2; eructations11 (empty5, bitter3). Nausea3; vomiting4. 2l8 COLOCYNTH. Feeling of pressure in the epigastric region2. A sensation of heat in stomach2; burning in stomach2. Sensation of soreness in region of stomach2. Griping, crampy pains in the epigastric region10: after eat- ing3. ABDOMEN. Colicky pains in various parts of abdomen16: about umbili- cus11 ; pains described as violent10, griping10, cutting4, stitching2, drawing2; aggravated by motion2, or from eating3; relieved by evacuation of stool or flatus7, by bending over2 (pressure ?■). Isolated stitches in iliac region4. Continued loud rumbling in the abdomen11: accompanied by great discharge of flatus8. Distention of abdomen7: accompanied by great sensitive- ness5. Uneasiness in the bowels with feeling as of approaching diarrhoea4; colicky pains in abdomen with urging to stool2. RECTUM AND ANUS. Burning at the anus5: following loose stool3. Itching at the anus2. Great tenesmus10: accompanied by tormina"; with stools loose7, bloody3, or mucous2; better after stool2. Frequent urging to stool8: with griping3, and with inability to resist3; aggravated after eating2. STOOL. Diarrhoeic stools22: preceded by griping pains5. Thin, watery, painless stools7. Copious fecal stools14: accompanied by great discharge of flatus2. Torpidity of the bowels, stools hard and unsatisfactory4. Stools pappy10, thin8, mucous3, bloody3, yellow3, brown2. Copious discharge of flatus6. COLOCYNTH. 219 URINARY ORGANS. Burning at orifice of urethra after urinating3. Copious urination8: frequent and copious4. Urine passed too frequently6; urine scanty4. Urine deposits a hard sediment2. SEXUAL ORGANS. Excited sexual impulse3. RESPIRATORY ORGANS. Oppression of the chest5. Transitory stitches in the chest5: left side5; both sides2. NECK AND BACK. Rheumatoid pains in the nape of the neck4: worse on motion2. Painful weariness in the lumbar region4. LIMBS. Upper Limbs. — Pains in upper extremities7: drawing7; transitory stitches3. Feeling of tension, pressing or stiffness in the upper extrem- ities6: pressing3, tension2, stiffness2. Lower Limbs.—Feeling of tension in the lower limbs, prin- cipally in the joints5: tension and stiffness2. Pains in various parts of lower limbs11: drawing8, stitching6, tearing4, pressing4. Feeling of heaviness or weakness of the lower limbs7. Numbness of the lower limbs4: feeling as if they were going to sleep2. SKIN. Itching in various parts of the body4: inducing scratching3. Furuncles3. SLEEP. Sleepiness with frequent yawning4. Sleep with vivid dreams5; restless3; with frequent waking3. 220 COLOCYNTH. CHILL. FEVER. SWEAT. A feeling of coldness5: over the whole body2. Febrile movement'': preceded by chill2, and accompanied by thirst2. AGGR OVATIONS. Colicky pains: worse after eating3; from motion2; towards evening3. Pains in various parts worse during rest3. AMELIORATIONS. Colicky pains: evacuation of stool or flatus7; relieved by pressure3; quiet2. Pains in limbs relieved by motion2. THERAPEUTIC APPLICATION. The therapeutic application of colocynth, in accordance with the symptomatology, is somewhat limited. We find the remedy almost a specific for colicky pains in the stomach or bowels; the pains being described as violent, cutting or griping* most frequently about the umbilicus, and relieved by bending over (pressure) or from discharge of flatus or loose stool. This condition may be caused by indigestion; or it may be, as Dr. Farrington terms it, a "nervous colic" dependent upon irrita- tion of the nervous system, rather than on any inflammatory condition. Colocynth may, however, be found useful in diarrhoea pre- ceded by griping pains, the stools yellow and pappy or thin; or during the course of a dysentery, the stools consisting of either blood and mucus or mucus alone, accompanied by great tormina and tenesmus, with relief after stool. The peritonitis is probably that "caused by extension of inflammation from the abdominal organs covered by the mem- brane and is of a circumscribed character". Should this extend to the covering of the ovaries we may COLOCYNTH. 221 have the ovarian neuralgia, for which colocynth has repute. But it is not alone in ovarian neuralgia that colocynth has proved of service. Its "grand sphere lies among the neuroses, and its pathogenesis has led to brilliant cures of neuralgia of the fifth and sciatic nerves." The pains in the head range from dull and pressing to acute and are more especially in the temples. Pressive, drawing pains are also found in various parts of the face, and in the orbits and teeth. Transitory stitching pains are found in various parts of the arms and chest. In sciatica the pains are sudden, sharp and stitching, or they may be drawing, tearing, cramplike in character, and may be followed by numbness of the legs and feet. The pains also approach a rheumatoid character, being frequently in the joints, with feeling of tension and stiffness. The headache of colocynth deserves more than passing notice. It appeared in ten provers and is described as tensive, pressing, at times violent, and usually located in the temples and forehead. Dr. Farrington classes it as rheumatic or gouty headache, and says it is an affection in which colocynth is very much neglected. It would also seem that some application to urinary affec- tions might be made. The " copious urination " points to an increased secretion, but probably less than the "frequent desire to urinate" would imply. Perhaps the effect is a part of the general action of the drug on solar and abdominal plexus, which it would be well to bear in mind. 16 222 CROTALUS. CROTALUS. REMARKS ON PROVINGS. The symptomatology here considered is that of the virus of the crotalus family, and not of any one particular variety of snake. It is unfortunate that enough records of the effects of the hor- ridus, the durissus, the cascavella, or some other variety could not have been collected from which to make a synthesis, but as the poison of these different varieties is probably identical, or at least the effects are so similar as to render differentiation almost if not quite impossible, a symptomatology of the effects of the virus of the crotalidse, even though we accept it under the pro- test of an infringement of a general principle, yet may be con- sidered legitimate. This synthesis, then, must be known simply as a study of crotalus. The records that have been rejected are: No. 8, Mrs. T., a clinical report. No. n, Dr. Oates, complicated with effects of alcohol. No. 14, Drs. Humbolt and Manzini's observations of many inoculations are too general for any other use than as foot- notes. Nos. 5 and 13 are both by Dr. Hay ward, and although one is the result of internal medication and the other the result of inoculation, yet because made by the same experimenter they have been combined as one record. Of the cases of bites rejected: No. 1 has local symptoms only. No. 2, section "b," is mixed with the effects of other drugs. No. 19 is a record of a man intentionally allowed to be bitten in the hope of being cured of leprosy. No. 21 is complicated with effects of alcohol and ammonia. According to general rule no symptom is recorded in either a proving proper or a poisoning case after the administration CROTALUS. 223 of a second drug; in consequence, only a very small number of symptoms of some of the cases of bites have been utilized; e. g., both Nos. 7 and 14 have but two available symptoms, respectively. Our symptomatology of crotalus has been drawn from thirty records: eleven are "provings," nineteen are "poisonings." The subjects were seventeen men, nine women, one boy, one girl, and two of unstated sex, but probably male. Besides the bites and the inoculation of one-sixth of a drop of a mixture of equal parts venom and glycerine, the drug was proved in various preparations from the crude virus up to the third centesimal dilution. All local effects of inoculations and of bites have been care- fully omitted. GENERAL SPHERE OF ACTION. It is to be regretted that more careful and scientific exami- nations have been made of post-mortem appearances in lower animals than in man; but from the material at command, together with the symptomatology, an idea of the general action of rattlesnake virus may be obtained. Apparently, crotalus acts most powerfully directly upon the blood, and through this fluid the nerve centres are poisoned. The red corpuscles are attacked, and their crenated edges show a tendency to the disintegration preceding dissolution of the corpuscle. As a result of impaired function of the red cor- puscles, the blood fails to absorb its proper supply of oxygen, and hence, when a sufficient number of corpuscles are rendered inoperative, death ensues as a result of the intoxication of the medulla by the accumulated carbon dioxide. The blood is found to be uncoagulable, because the albumen can not be oxidized. All other nerve centres, both cerebro-spinal and sympathetic, suffer more or less from the same cause, and the results of crotalus poison may properly be attributed to interference in the nutritive function of the blood. 224 CROTALUS. As may be expected from an agent which attacks so directly the food-carrier of the organism, but few tissues escape its effects, the mucous and serous tissues both yielding to the poison; the meninges of the brain and spinal cord, the peri- cardium, and the mucous linings of the air passages, and intes- tinal tract are all seriously involved. SYMPTOMATOLOGY. (Provings, thirty : men, seventeen; women, nine; one boy ; one girl; sex not stated, but probably male, two.) GENERALITIES. * Malaise4. Languor2. Weakness5: powerlessness2. Pains are intermittent2. Prostration8: syncope4. In morning on awaking feels as if bruised2. Hemorrhage because of non-coagulability of blood4: from mucous membrane2. Swelling of whole body3. Burning pain in trunk, increased by touch2. Restlessness2. MIND. Delirium5. Sensitive to impressions3: noises2. Mental depression3. Uneasiness4: amounting to anxiety3. Torpidity of intellect4: thought is an effort2. Forgetful2. In writing, spells words incorrectly2. HEAD.t Vertigo5: while sitting, so great that equilibrium was main- tained with difficulty2. Confusion2. * Humbolt and Manzini report lassitude in fifty-nine out of seventy-four inoculations; jaundice in sixteen out of seventy-four cases, and state that the intermittent character of several of the symptoms is one of the most interest- ing and important of the points observed. t Humbolt and Manzini found headache in 160 out of 187 inoculations. CROTALUS. 2 25 Headache9: frontal7 (over left eye2, in right side of forehead3); in left side of head3; with nausea2. Pain intermittent2. Acute pain2. Dull, heavy sensation in head4: in frontal region2. EYES. Irritation of the conjunctiva5: red2; rupture of conjunctival blood vessels2. Dilated pupils2. Obscuration of vision4: during reading2. EARS. Sensitive to noise2. NOSE.* Sneezing2. Discharge of blood from nose2. FACE. Face pale3; swollen4; color heightened2. MOUTH.f Tongue swollen2. THROAT.J Irritation of throat5: sensation of swelling of velum2. Difficult deglutition2. STOMACH. Great thirst4. Nausea5. Emesis8. Nausea and emesis2. Sense of discomfort in epigastrium4. * Humbolt and Manzini report coryza in sixteen out of seventy-four cases inoculated. f Humbolt and Manzini found bitter taste in fifty-four out of seventy-four cases. X Humbolt and Manzini found angina tonsillaris in seventeen out of seventy-four cases inoculated. 226 CROTALUS. ABDOMEN* Pain in abdomen3: pain in colon2. STOOLS. Diarrhoea4. Constipation2. URINARY ORGANS. Urine increased in quantity2; high colored3. RESPIRATORY ORGANS. Weakness of voice2. Cough4: with tickling2; with expectoration3; of blood2. Respiration labored5: and slow2. CHEST. Oppression of chest3. Pain in left breast2. Pain in chest, increased by touch2. HEART AND PULSE. Rapid action of heart2. Pulse increased in frequency5. Pulse weak10: almost im- perceptible3. Pulse imperceptible at the wrist2. LIMBS. Extremities cold4: and insensible2. Pain in shoulder3; in elbow2. Pain in thighs, worse on touch or movement2. Contraction of muscles of leg2. Pain in ankles2. SKIN. Eruption on skin2. Small tubercles under the skin2. Dark spot under the skin2. Skin dry2. Irritation of skin4: itching2. Surface of body cold6. * Humbolt and Manzini report colics in fifty-four out of seventy-four cases. CROTALUS. 227 SLEEP.* Sleepy3: yawning2. Sleep full of dreams3: of an unpleasant character2. CHILL. FEVER. SWEAT.f Coldness4. Increased secretion of perspiration3. AGGRAVATIONS. Pain worse on movement2. Pains in trunk increased by touch3: burning pains aggra- vated by touch2. Pain in thighs worse on touch or movement2. THERAPEUTIC APPLICATION. As shown in its general sphere of action, crotalus affects primarily and profoundly the blood; we will therefore find the drug of service in affections depending upon disturbance in the functions of this fluid. Venous congestions generally and in- flammations of a low type, with tendency to effusions from either mucous or serous surfaces, may receive benefit from the virus. These congestions also show signs of ecchymoses or even of haemorrhages. In an advanced stage of sanguineous degeneration, where gangrene of some part of the body exists, crotalus may restore general and local vitality. In adynamia from zymosis or sepsis, and in conditions with purpuric manifestation, the virus may be of use. Delirium.—In delirium accompanying the low fevers, typhoid, remittent, yellow fever, etc., crotalus may be pre- scribed. There is, however, no characteristic form of delirium, unless the dreams of an unpleasant nature be so regarded. Cerebro-Spinal Meningitis.—In this affection delirium is * Humbolt and Manzini found drowsiness in ten out of seventy-four cases. f Humbolt and Manzini found coldness in thirteen out of seventy-four; heat in forty-six out of seventy-four, and perspiration in seventeen out of seventy-four. 228 CROTALUS. also present; the patient is sensitive to external impressions, especially noises; we find obscuration of vision with dilated pupils; contraction of muscles; and finally there will be ecchy- mosis showing the fluid state of the blood. Crotalus is best indicated in the malignant epidemic form of meningitis cere- bro-spinalis. Scarlatina Maligna.—In scarlatina and all other zymotic diseases with a tendency to fatal degeneration, crotalus may prove useful. Diphtheria.—The throat symptoms and general malignant tendency call attention to crotalus in diphtheria. Yellow Fever.—In yellow fever no drug is generally con- sidered more homoeopathic, and with our knowledge of its health-perverting peculiarities we must also recommend it. There are as indications of crotalus, malaise, weakness, power- less prostration, restlessness, mental depression, torpidity of mind, sensitiveness to noises, delirium, obscuration of vision with dilated pupils, flushed face, thirst, nausea and vomiting; and from the general action of the drug, vomiting of blood may be inferred; epistaxis also sometimes occurs. The vomited blood being degenerated and highly carbonized will be dark or black, hence the "black vomit" of yellow fever should be a "characteristic" indication for crotalus. There will also be ab- dominal pains, urine highly colored, loose bowels, feeble rapid pulse, hurried respiration, cold extremities with contraction of leg muscles, and finally death from poisoning of nerve centres by the vitiated blood. Typhoid Fever.—The general symptoms characteristic of the altered state of the blood in typhoid fever indicate crotalus. There is frontal headache and vertigo; the pains in the head are intermittent; nausea is present, the hearing is intensified and noises annoy; the tongue is swollen, and inference would lead us to expect dryness; delirium is present; the bowels may be constipated, but more frequently there is diarrhoea, and we may legitimately expect intestinal haemorrhage. The ten- dency is to a rapid and fatal termination. Although a certain CROTALUS. 229 number of abdominal symptoms are present, yet it is in the •cerebral or nervous type of fever where crotalus may be most useful. Remittent Fever.—The drug should be studied in remittent fever when the tendency is to the pernicious variety. Purpura Haemorrhagica, typhus fever and variola, all pre- sent indications for this virus; and traumatic gangrene may find its similimum herein. In fact, crotalus should be studied in all low grade fevers with hsemorrhagic tendency, and in all malignant local inflammations with tendency to general pysemic infection. On the subject of crotalus in fevers, we suggest a careful study of Dr. C. Neidhart's monograph " On the Efficacy of Crotalus Horridus in Yellow Fever; also in Malignant, Bilious and Re- mittent Fevers." 230 CROTON TIGLIUM. CROTON TIGLIUM. REMARKS ON PROVINGS. In preparing this symptomatology, the records of twenty- eight experimenters are used out of a collection of forty found in the Cyclopaedia of Drug Pathogenesy. Ten of the twelve that were omitted are so-called provings and two are from the poisoning records. The reasons for omitting these twelve records are as follows: Provings Nos. 9 and 13 and poisonings Nos. 1 and 4 are clini- cal records; provings Nos. 25, 26, 27, 29, 30, 31, 32, 33 are records of local effects only. Besides these it has been neces- sary to omit sections of two other records, viz.: Observations "a" and "b" of proving No. 20,are voluminous collections of symptoms supposed to be the result of inhaling the oil, and are so multitudinous as to have a strong flavor of the purely sub- jective; observations "a" and "c" of record 23 have been omitted, because they are reported as having been produced by the fifteenth dilution. The preparations used by the provers were all low, the ma- jority being the crude oil. The highest attenuation was the fourth centesimal. The seed was swallowed in three cases. GENERAL SPHERE OF ACTION. Croton tiglium acts most prominently upon the mucous membrane of the intestinal tract; the whole length of the canal manifesting signs of functional perversion. This is shown in the irritated throat and oesophagus, the nausea and vomiting with anorexia, pains in the stomach and abdomen, diarrhoea, etc. Many reflex symptoms also result therefrom, among which may be noted vertigo, confusion of the head, mental depression, rapid pulse, coldness of extremities, etc. CROTON TIGLIUM. 231 The skin also shows signs of disturbed function, in the ap- pearance of an eruption, which is probably a pure effect inde- pendent of the drug's action upon the alimentary canal. The disturbed dreams, increased perspiration and copious urinary secretion, may all be due to irritation of the digestive mucous membrane. So far as experiments have been made we are not yet justi- fied in extending the general sphere of action of croton oil beyond the mucous membrane and the skin; that is, the en- veloping membranes of the bod)-. Unfortunately we have no recorded post mortem appearances in man to guide us in making an estimate of the general action of croton, but from fatal experiments upon the lower animals we are led to the belief that its effects are largely, if not entirely, due to its local irritating power. SYMPTOMATOLOGY. (Provers, twenty-eight: males, sixteen; females, eight; one boy; sex not stated, but probably male, three.) GENERALITIES. Weakness10: trembling of extremities2; difficulty in walking a short distance2; weariness2. Malaise3. MIND. Mental depression4: sadness2. Crossness2. HEAD. Sweat on forehead2. Vertigo5: with nausea2. Confusion of head5: confusion of sinciput2. Pain in crown of head3: shooting in character2. Pain in temples3: sudden and sharp2. Pain in forehead2. 232 CROTON TIGLIUM. EYES. Could scarcely open eyes; the eyeballs seemed to be in- filtrated2. Dimness of vision2. Blindness3. Lachrymation3. EARS. Loss of hearing and sight2. Pain in ear3: aching in left ear2. NOSE. Irritation of inside of nose4: inflammation of nose and whole face2. FACE. Nose and whole face inflamed2. Features distorted2. Face pale2. Increased heat of face3. Sweat on face3: forehead2. Eruption on face2. MOUTH. Taste perverted6: bitter3; sweetish2; flat2. Increased secretion of saliva6. Lips dry2; burning3. Dryness of mouth2. Burning sensation in mouth2. Sensa- tion of warmth in mouth2. THROAT.* Sensation of irritation in throat16: in fauces6. Sensation of scraping in throat10: in fauces4. Tickling in throat2. Sensa- tion of dryness in throat3: in fauces2. Sensation of burning in throat7: in fauces5. STOMACH. Sensation of burning in oesophagus6: of scraping4; of burn- ing and scraping3. (These are probably local effects.) * These throat symptoms are probably the result of the local effect of croton upon the mucous membrane, such as might be due to any mechanical or chemical irritant. CROTON TIGLIUM. 233 Nausea12. Emesis8. Nausea and emesis6. Vomiting of mucus3; of bitter substance3. Eructations6: with nausea3; of water2. Nausea4. Anorexia5. Pain in the stomach5: " stomachache "2. Sensation of burn- ing in stomach3; fulness3; pressure5. Empty feeling in stomach2. ABDOMEN. Pains in abdomen18: acute13; colicky4; "cutting"5; "pinch- ing"3; "shooting"2; pains followed by stool4; pains with stool3; pains'with rumbling in abdomen2; pains in epigastrium3; pains in umbilical region8 (griping4, shooting2, cutting2, pinch- ing2). Abdomen distended3. Sound as of splashing water in ab- domen2. Discomfort in hypochondrium3: pains2; discomfort in splenic region2. Sensation of coldness in abdomen2. RECTUM AND ANUS. Burning in anus3; pains in anus6. STOOL. Diarrhoea19: liquid stools12; watery2; containing mucus7 (with tenesmus3); stools yellow5; copious3; involuntary2; hurried call to stool4; stool expelled quickly4. Discharge of flatus3: offen- sive2. URINARY ORGANS. Urinary secretion increased7. Sediment in urine3: of brown color2. Urine cloudy2. Burning in urethra when urinating2. RESPIRATORY ORGANS. Voice not clear3: hoarse2. 234 CROTON TIGLIUM. CHEST. Discomfort in chest5: oppression3; tightness3. Sudden pains in chest3: tearing in character2. Anxiety in chest2. HEART AND PULSE. Pulse rapid3; weak4; "small"2. NECK AND BACK. Chilliness over back2. Pain in posterior cervical region2. LIMBS. Extremities cold3. Sudden pain in left foot3: tearing2. Tearing pain in right shoulder2. Tearing in right upper limb2. Tearing in fingers3. SKIN. "Great irritation all over body"2. Cutaneous eruption3: vesicular and desquamating2. SLEEP. DREAMS. Somnolence3. Restless sleep3. Dreams disturbing sleep4. CHILL. FEVER. SWEAT. Sensation of general coldness3. Sensation of coldness"1 in back2. Slight chill2. Sensation of increased heat of body5. Perspiration6: on forehead2. THERAPEUTIC APPLICATION. To judge from the foregoing pathogenesy, croton tiglium finds its therapeutic use chiefly in derangements of the digestive organs and in skin troubles. CROTON TIGLIUM. 235 Diarrhoea.—The stools are liquid, with involuntary tendency, hurrying the patient, and shooting out suddenly. The dis- charge is copious and yellow. The stools may, however, con- tain mucus, in which case there is likely to be tenesmus. The discharge causes burning in the anus. There are also, accompanying, pains and rumbling in the abdomen, with a sound as of splashing water therein. The pains are quite acute, being shooting, cutting and pinching. Indigestion.—In attacks of acute indigestion croton tiglium should be studied; particularly after the ingestion of locally irritating substances. There is irritation throughout the ali- mentary canal; burning and scraping in the oesophagus; pains, with burning, pressure and sensation of fullness (one or all), in the stomach; eructations, nausea, vomiting, and most naturally anorexia. Vertigo and confusion of head will also be present, with the headache principally in the front part. As a natural result of such an irritated condition of the intestinal canal, diarrhoea frequently supervenes upon the stomach derangement. Cutaneous Diseases.—From the symptomatology no very definite indications for croton tiglium can be drawn in skin troubles; but we know, however, that the drug will produce an eruption that vesiculates and finally desquamates, and it will also produce a sensation of great irritation all over the body. These meagre facts, together with the well-known power of croton to produce local irritation and even pustula- tion, render legitimate its use in eruptive diseases, including local effects of rhus toxicodendron. Eczema.—In eczema with tendency to pustulate, the drug should be studied. In febrile conditions croton tiglium may be found indicated. The patient has a slight chill, or more probably there is merely a sensation of general coldness; a sensation of increased heat of body presents, and finally perspiration appears. Of what this febrile state may be the precursor we have no positive data; but possibly intermittent fever may here find its simili- 236 CROTON TIGLIUM. mum, particularly if the attack be of the variety involvings prominently the digestive organs. General Indications.—The concomitant croton symptoms most frequently present when the drug is indicated, are, weak- ness, which may almost amount to exhaustion, with tendency to perspire easily, mental depression with perhaps crossness,, and restless sleep. Whatever may be the morbid condition calling for croton tiglium, examination will most frequently find the primary cause of the disturbance to be in the alimentary canal. This. is a legitimate inference from the pathogenesis of the drug. CUPRUM ACETICUM. 237 CUPRUM ACETICUM. REMARKS ON PROVINGS. There appear to be no provings of the acetate of copper except those recorded by Hahnemann. Our knowledge of its effects on the system is derived chiefly from the observation of cases of poisoning. In the Cyclopaedia of Drug Pathogenesy there are twenty-eight instances of poisoning by this drug, and these have been used in the following symptomatology. A number of sections in the article on cuprum were omitted be- cause they described the effects of forms of copper other than the acetate. Several of the sections describe the poisoning of a group of people, and where these records could be separated and individualized this was done; otherwise the group has been counted as one. GENERAL SPHERE OF ACTION. The effects of cuprum are most decided on the mucous mem- brane and the nervous system. Its salts have power to cause inflammation of the former, but it is upon the latter that its most powerful effects are perceived. It appears to act as an irritant to the cerebro-spinal nervous system, the results being most marked in the higher nervous centres of the brain and the parts of the body connected with the pneumogastric nerves and the anterior portion of the spinal cord. In the brain a form of intoxication is produced closely re- sembling mania; connected with which is an irritation of the convulsive centre which throws the victim into spasms, that may be general in character or, on the other hand, affect but a single group of muscles. 17 238 CUPRUM ACETICUM. Irritation of the vagi is shown by persistent vomiting as well as by interference with the regularity of respiration and heart rhythm. That cuprum aceticum affects the spinal cord seems evident from the violent neural symptoms exhibited, especially those of the abdomen and limbs. Severe griping pains occur in the bowels and severe cramps are felt in the leg-muscles. It is not wholly improbable that even the inflammation of the gastro-intestinal mucous membrane, which is so prominent a feature of copper poisoning, may be due, not so much to the local effect of the drug as to the action of the poison upon the trophic or other nerves ending in the mucous membrane. SYMPTOMATOLOGY. (Provers, twenty-eight: men, thirteen; women, thirteen; un- certain, two.) GENERALITIES. Extreme weakness5. General prostration3. Convulsions12. Unconsciousness4. Emaciation5. Pains felt generally over the body2. MIND. Mania3.* Hallucinations2. * Anxiety2. Depression of spirits4. HEAD. Vertigo2. Headache5: severe3. * Several other cases occurred, but the exact number could not be as- certained. CUPRUM ACETICUM. 239 EYES. The eyes are sparkling and prominent2. The eyes appear sunken3. Pupils dilated2. FACE. Face flushed2. Face pale7: pallid5. Haggard appearance5. Jaws tightly closed2. MOUTH. Soreness of the gums3: gums retracted from the teeth2. Line of color along the edges of the gums and teeth4:* purple2, greenish2.* The tongue is moist4, and red2. Coating on the tongue3: cream-colored2. STOMACH. Anorexia6. Thirst7: violent3. Hiccough3. Nausea3. Severe retching2. Vomiting13: frequent2; violent3. Matters vomited: greenish3 (greenish mucous2); blood2. Pains in the stomach6 :# griping2. Burning sensation in the oesophagus2. Epigastrium very sensitive to touch5. ABDOMEN. Flatulent distention of abdomen7: hard and painful4. Abdomen flattened3. Pains in the abdomen16: violent10; colicky or griping6. Exquisite sensitiveness of the abdomen to pressure3. STOOL. Constipation4. '^Several other cases occurred, but the exact number could not be ascer- tained. 24O CUPRUM ACETICUM. Diarrhoea9: "purging"2; "frequent urging"2. Watery stools6: copious3; greenish4. Loose stools preceded by pain8, by vomiting8. URINARY ORGANS. Urine scanty3. Tendency to suppression of urine2. RESPIRATORY ORGANS. Respiration accelerated2. Breathing short2. PULSE, ETC. Retarded pulse2. Pulse quickened4; "contracted"3; weak3; small3; irregular2; hard2; full3. LIMBS. Stiffness in the muscles2. Tremulousness of the limbs2. Pains in the limbs5: violent cramps4—in calves3. SKIN. Surface cold5. SLEEP. Slept but little during the night4. t CHILL. FEVER. SWEAT. Coldness of the surface5. Feverishness2. Sweat7: cold sweat3; symptoms relieved by sweat2. THERAPEUTIC APPLICATION. •The general characteristics of cuprum aceticum are: (1) Prostration of the vital forces; (2) Emaciation; (3) A strong tendency to convulsive action, which may be associated with CUPRUM ACETICUM. 241 mania or unconsciousness and accompanied by severe paroxys- mal pain; and (4) Exquisite sensitiveness of the part affected. The continual reception of copper salts into the system is characterized by the establishment of a line of color along the gums and teeth at their junction, described by some as being purple, and by others as green. Mania.—Few remedies in our materia medica offer greater promise of usefulness in mental affections than cuprum aceti- cum. The provers appear to be quite deranged; they are frightened or mad and have various hallucinations, imagining themselves to be different people. The tendency is towards depression of mood rather than exaltation. Meningitis or symptoms caused bv the retrocession of an eruptive disease are often relieved by this remedy. Tetanus, especially when beginning as trismus, or when that form is assumed, may be controlled by the acetate. In these cases the jaws are tightly closed, the face pale and hag- gard and the muscles are held in tonic contraction. Convulsions, whether produced by epilepsy or any other cause, and especially when due to retrocession of the exanthe- mata, are often warded off by cuprum aceticum, or, indeed, the affection may be entirely cured by its use. It may therefore be relied upon when convulsions impend during the course of one of the eruptive diseases or other affections of childhood. In these cases the administration of a few doses of cuprum aceti- cum clears away the threatening symptoms and allows the case to proceed in the usual manner. The symptoms which indicate the onset of spasms and which demand this remedy are paleness of the face, almost to blue- ness; firm closure of the jaws; delirium, more or less pronounced ; sparkling eyes, which appear to be protruded; increased rapidity of respiration; some irregularity of the pulse and spasmodic movements of the muscles, which may increase to severe cramps. In other spasmodic conditions cuprum aceticum affords marked relief. Among them are laryngismus stridulus, ner- 242 CUPRUM ACETICUM. vous asthma, whooping-cough, chorea and angina pectoris. In pertussis the cough is so violent as to threaten suffoca- tion, after the cough the child is stiff and motionless and seems likely to fall into spasms or really does so. Affections of the stomach and bowels, especially those at- tended by marked nervous phenomena, as vomiting or spas- modic action of the involuntary muscles (cramps), often de- mand the use of cuprum aceticum. When the symptoms correspond it may be employed in any form of irritation of the alimentary tract, but its similimum is found in Asiatic cholera, which may be taken as the type of disease which cuprum may be depended upon to relieve. Cholera.—The opinion expressed by Hahnemann, that cop- per would be found to be a potent remedy in cholera, was based upon a sound pathogenetic foundation, and has been abundantly confirmed by the results. That the pathogenesis of cuprum aceticum corresponds closely with the symptomatology of cholera none can doubt. On the former is found severe ab- dominal cramps, often violent; cramps in the calves of the legs; exquisite sensitiveness of the abdomen; nausea, violent retching and vomiting of greenish matters and blood; burning feeling in the oesophagus; diarrhoea, consisting of copious, watery stools, preceded by griping; coldness of the surface. The general condition is one of extreme prostration and rapid emaciation. CYCLAMEN EUROPIUM. 243 CYCLAMEN EUROPIUM. REMARKS ON PROVINGS. The Cyclopaedia of Drug Pathogenesy furnishes the records of twenty-eight provers. Nos. 14 to 18 inclusive are excluded, as they refer to girls who were under treatment in a Lock Hospital for gonorrhoea, condylomata or excoriations of the vagina. No. 28 is also rejected, as the weak eyes of the prover vitiate the record. The tincture and first dilution were used, the initial dose in most instances being five drops, followed by increased quanti- ties, until in one case the final dose amounted to fifty drops. GENERAL SPHERE OF ACTION. The parts of the body chiefly within the range of the influ- ence of cyclamen are the brain, eye, ear, digestive tract and female sexual system. Its action upon the eye is marked, while its effect upon the female organs is equally pronounced. SYMPTOMATOLOGY. (Provers, thirteen: males, nine; females, four.) GENERALITIES. Exhaustion4; prostration of the whole body2. MIND. Cross, ill-humored3; anxiety2. Depression of spirits5. 244 CYCLAMEN EUROPIUM. HEAD. Confusion of head9; vertigo4. Heat in head3; heaviness of head2. Headache3; pain in right temple2. Pressure in temples2, in forehead2.* EYES. Flickering before the eyes3. Burning in eyes3. Dimness of vision2. NOSE. Coryza2; frequent sneezing2. EARS. Noise in ears3. MOUTH. Acrid, salty taste2. Jerking pains in upper teeth2. Flow of saliva2. Furred tongue2. THROAT. Scraping in throat3. Fauces red2. STOMACH. Eructations8: tasting of drug2; acid2. Anorexia3; pressure in stomach3. Nausea5: with vomiting3. Great thirst2. ABDOMEN. Griping in abdomen4; distention4. Rumbling in abdomen3: with pain2. Pain in umbilical region2; in renal region2. * In Nos. 14 to 27 frontal headache occurs in six. CYCLAMEN ELROP.EUM. 245 STOOL AND ANUS. Diarrhoea6: watery2. Tenesmus attending stools2. Shooting in rectum2; pressure in rectum2. URINARY ORGANS. Urging to urinate2. Frequent micturition, quantity increased3: with pain in bladder2. SEXUAL ORGANS. Female.—Menses return too soon3. Menses cease and return2. RESPIRATORY ORGANS. Irritation of larynx causing dry cough2. Stitches in left chest2; in marnmse2. HEART AND PULSE. Pulse accelerated3. LIMBS. Heavy feeling in feet preceding menses2. SLEEP. Restlessness at night4; yawning4. Sleep disturbed by dreams5. Exhaustion on waking2. AMELIORATION. Heaviness of feet relieved by return of menses THERAPEUTIC APPLICATION. The clinical use of cyclamen has been unduly restricted, the drug being undoubtedly overshadowed to a great extent by its important analogue, pulsatilla. 246 CYCLAMEN EUROPIUM. We may expect efficient action from cyclamen in the follow- ing conditions: Melancholy and peevishness, when due to menstrual de- rangement, are accompanied by paralytic heaviness of the feet. Both conditions disappear on the establishment of the men- strual flow. Coryza is accompanied by frequent sneezing. In digestive derangements we find loss of appetite, sour eructations, pressure in stomach, nausea, watery diarrhoea and great thirst. In the female sphere inconstancy is a noticeable trait of the menstrual flow, which stops and starts again. The menses are prone to return too soon. Headache may be attended with vertigo, roaring in the ears, dimness of vision, flickering before the eyes, and in some cases the appearance of luminous spots. Tinnitus aurium is strongly suggested by the effects upon the ears. The symptoms manifested in the eyes, appearing with such constancy and intensity, commend cyclamen as a valuable ophthalmic remedy. GELSEMIUM SEMPERYIRENS. 247 GELSEMIUM SEMPERVIRENS. REMARKS ON PROVINGS. Both the proving and the poisoning cases found in the Cyclopsedia of Drug Pathogenesy have been utilized, with the following exceptions: Under proving No. 8 (Ringer), paragraph "i" has been omitted, because it is clinical; and so likewise have the local effects of the topical application of gelsemium noted in para- graph "1." Among the poisonings, case 1 has been omitted from the body of the symptomatology and cited in foot-notes, because partaking too strongly of the nature of inexpert generalizations; case 3 is also cited as a foot-note, the one symptom given being of an indefinite character; case 4 is also indefinite, and is ex- cluded ; in cases 5, 6, 13 and 14, the effects immediately ante mortem are excluded, and in cases 8 and 9, symptoms follow- ing administration of antidotes have been omitted; the neu- ralgic symptoms in cases 13 and 15, for which the drug was taken, and finally, case 16, which is purely clinical, are also rejected. Cases 17, 18, 19 and 20 in the Appendix, are also omitted, because No. 17 most probably used the drug for some unstated condition, No. 19 mistook gelsemium for some other drug which no doubt she was taking for some modification of "health, and Nos. 18 and 19 are clinical. Case 7, a sailor "con- valescing from periostitis," has been used because his recorded symptoms bear no relation to the periostitis, and are in accord with the symptoms occurring in other provers. Furthermore, it should be mentioned that Dr. Douglass' generalizations of drug effects taken from at least fifty persons have been used as though obtained from one experimenter only, except where the results are obviously from two or more provers; this also applies to Dr. Ringer's generalizations from 248 GELSEMIUM SEMPERVIRENS. six persons on seventeen occasions. Counting these cases as equivalent to four provers, we have in all twenty-two experi- menters from whom the symptomatology is deduced. The preparations used in proving range from the fluid ex- tract up to the 6th dilution, and nothing above this limit; but the majority of the results were obtained from the tincture. GENERAL SPHERE OF ACTION. Judging from the revelations of autopsies of the lower animals, which are verified by post mortem appearances in human be- ings, together with suggestions from pathogenetic effects both objective and subjective, gelsemium acts prominently upon the cerebro-spinal and the vegetative nervous system. As a result, muscular power is diminished ; the enfeeblement sometimes amounting to complete paralysis; there is even in- terference in the action of the heart which has resulted in com- plete cessation while in extreme diastole. Particularly are the ocular muscles affected. This depressing effect extends to the mind, and the mental attitude seems to be consonant with the physical condition. From the action of gelsemium upon the involuntary nervous system, there is more or less venous stasis in various parts 01 the body. Both serous and mucous tissues reveal the influence of the drug; the cerebral substance and membranes are hyper- semic, likewise the mucous lining of the stomach and intestines. From these examples of its effects it is fair to infer that gelsem- ium may also cause a sanguineous congestion in any other of the serous or mucous tissues. In fact, in the lower animals where a greater number of observations of effects of fatal doses have beeii observed than in man, the substance and membranes of the spinal cord were found congested, and in a number of cases there was considerable exudation of blood. In some of these cases the substance of the heart was unnaturally red (con- gested) and softened. A peculiarity of the blood, in cases dead from the drug, is its GELSEMIUM SEMPERVIRENS. 249 uncoagulability. This shows a change in its vital constituents, similar to that produced by other drugs classed as narcotics and sedatives, which change consists in either prevention of oxidation of albumen or deprivation of the contractile power of fibrin. SYMPTOMATOLOGY. (Provers, twenty-two: men, seventeen; women, five.) GENERALITIES. Pains11: dull6; acute8; shooting2; pressive3; drawing3; cramp- ing2; aching2; deep-seated2; shifting3. Decided restlessness2. More or less loss of muscular power13: complete motor paralysis4, during which consciousness is unimpaired2; trem- bling, with feeling of weakness2. Prostration6: excessive5. Easily fatigued3. Languid4: and listless2. Feeling as if intoxicated3. MIND. Mental excitement4. Low-spirited3. Incapable of mental application4: feels stupid2. Entire consciousness during complete motor paralysis2. Unconsciousness4. HEAD. Vertigo10: with imperfection of vision5; with total blind- ness2; "limited to brows"2; aggravated by movement3, or by standing2. Feeling of fulness in head3. Unusual feelings in head2. (Expressed as " head felt strangely," and "disagreeable sensation of head.") Headache9: dull6, pressive3, severe3; frontal7; (most marked over eyes3); in the temple3; in occiput5; over whole head3; with 250 GELSEMIUM SEMPERVIRENS. heat of face3 (and head2); accompanied by slight nausea2; worse towards evening2. Aching in occiput5: dull and aggravated by movement2; pain from vertex to occiput2. Headache and pain in eyeballs, often severe, aggravated by moving the eyes2. EYES. Pain in the region of eyes3: above eyes2; in orbits2. Ptosis8 (varying from partial to complete). Irritability of conjunctiva4. Lachrymation2. Pain in the eyeball3. Loss of power in eye muscles2. Strabismus2. Pupils dilated6.* Obscuration of vision12: diplopia8; objects appear indistinct, blurred5; misty2; distant objects especially are less distinct than usual2; blurred vision with dizziness3; glimmering appearance before eyes2; blindness4.f NOSE. Slight nasal catarrh3. MOUTH. Dryness of mouth5: of throat2; with moist tongue2. Pain in jaw2. Paralytic condition of muscles of lower jaw5. Imperfect articulation of words6. Tongue furred3: yellowish2. Disagreeable taste2. PACE. Face flushed3; livid3; pale2. Yellow color of face2. Heat of face2. *The opposite condition, contraction of pupils, was observed in five cases reported by Ringer. They were the only cases in which this condition was noted. t A child poisoned with the flowers '' suddenly complained that it could not see and died in a quarter of an hour." (Not of the four.) GELSEMIUM SEMPERVIRENS. 251 THROAT. Dryness of the throat3. Dysphagia, power of deglutition gone3. STOMACH. Eructations of flatus3. Nausea6: attended by indistinct vision2; accompanied by headache3. Pain in the stomach4: cardialgia2. ABDOMEN. Pain in hypochondriac region4: in left hypochondrium3 (in two cases sharp). Pain in umbilical region3: sharp in character2. Pain in hypogastrium2. Pain in left iliac region3. Pain in abdomen4. STOOL. Diarrhoea3: yellow2; "bilious"2. Emission of flatus2. URINARY ORGANS. Urine increased in quantity2. RESPIRATORY ORGANS. Respiratory movements diminished5.* Deep inspirations3. Irregular breathing3. Dyspnoea4. Accumulation of mucus in upper part of trachea, causing effort to get rid of it2. CHEST. Pains in the chest3: in the breast2. * In the cases of the poisoning of five deck hands, taken from Dr. Hale's " New Remedies," the breathing was so low it could hardly be discovered. (Not of the five.) 252 GELSEMIUM SEMPERVIRENS. HEART AND PULSE. Circulation very feeble3.* Pulse very feeble11: accelerated6. Pulse slow3. NECK AND BACK. Pains in the neck3: in upper part2. Pain in the back3: as in cold stage of ague2. LIMBS. Pain in limbs8: upper limbs4; shoulder2; under scapula2; in right arm3; in elbow2; in forearm3: right forearm2; in wrist2; in hand2; in fingers4: finger-joints2; in lower limbs6 (deep- seated and aching in character2); in the thigh4 (drawing2, and cramping3); in the knee5 (under the knee2); in the leg5 (acute3, of which two are shooting); in the calf3 (contracting in the left gastrocnemius2); in the toe3 (contractive pains2). "Rheumatic" pains2. Loss of power in the arms2. Numbness of extremities3: great numbness2. Extremities cold6: cold feet2. SKIN. Eruption3: on back and between shoulders; but chiefly on face, papular, of much the same color as that of measles, but the papulae are larger, and more distant and distinct; they are attended with little or no sensation2. Perspiratory action of skin increased5. SLEEP. DREAMS. Disposition to yawn3: yawning2. Sleepiness8: can not keep eyes open, fall asleep if not pre- vented3 ; look sleepy, dull and heavy from drooping of eyelids3. Sleep filled with dreams2. * In the deck hands the circulation is reported as '' very feeble.'' (Not of the three.) GELSEMIUM SEMPERVIRENS. 253 CHILL. FEVER. SWEAT. Chilliness4: lasting at least an hour, with feeble pulse and heat and pain of head, followed by general heat (pulse full and 80-100), mostly about head and face, succeeded by profuse perspiration; with concomitant thirst and languor2. Free perspiration5: profuse4. AGGR A V ATIONS. Motion aggravates general symptoms6: vertigo worse from walking2. Headache worse towards evening2. THERAPEUTIC APPLICATION. As will be understood from its general sphere of action, a large majority of the pathological conditions to which gelsem- ium is homoeopathic depend primarily upon derangement in one of the nervous systems; and secondarily, many others are caused from derangement in the vascular system, by which passive congestions are produced. Although comparatively few uses for the drug may be derived simply from its symptom- atology, yet with its basic field of action always before the mind many indications equally as good may be inferred there- from, which are probably quite as homoeopathic to disease as many of the actually observed pathogenetic details. A few symptomatic indications for the use of gelsemium are herewith appended. Emotional Derangements. —From the pathogenetic effects of gelsemium a condition may be observed which is very similar to the results of strongly excited emotions or nervous shocks. Legitimate inference would, therefore, lead to its use in the effects of grief, fright, and other neurotic disturbances. In such cases the pulse often becomes feeble and the respiration irregular, with occasional deep sighings at intervals. If the shock has been profouud, other functional troubles may be 18 254 GELSEMIUM SEMPERVIRENS. present, such as jaundice, muscular tremor and weakness, con- fused or imperfect vision, and other symptoms consonant with the general sphere of the drug's action. Headache.—The headache is dull, and may involve the whole head, but the frontal region is most prominently affected, while in some cases the occiput is the focus of the pain. The head feels full and hot, the heat extending to the face. The ache, especially when in the occiput, is aggravated by move- ment. Concomitantly there is nausea, vertigo, and pain in the eye- balls, which latter is aggravated by moving the eyes. The pain in the head extends in no specific direction, unless it be from the vertex into the occiput. Vertigo.—Vertigo is accompanied by imperfect or blurred vision, which may amount to blindness; or it may be accom- panied by strabismus. The erect position aggravates the vertigo, especially if move- ment be attempted. Sunstroke.—Gelsemium is strongly suggested in the effects of insolation, from its head symptoms, its muscular weakness and tremor, and its disinclination and inability to perform either mental or physical labor. The cerebral congestion, flushed face, confused vision, nausea, and general appearance of intoxication, with frequent, deep sighing inspirations are still further suggestive. Meningitis Cerebro-Spinalis.—When the following symp- toms are present the drug may be of use in cerebro-spinal meningitis: Occipital headache; dilatation of pupils; strabis- mus ; fulness and heat of head; nausea; partial or complete loss of consciousness; dryness of mouth; irregular respiration and feeble pulse; and finally, partial or complete motor paralysis. Apoplexy.—More or less motor paralysis, with consciousness unimpaired; head and face flushed and hot, with sensation of fulness in the head; imperfect articulation of words. Paralysis.—Complete motor paralysis, especially of arms. GELSEMIUM SEMPERVIRENS. 255 Extremities are cold and numb. The tongue is involved and articulation becomes difficult or impossible. Mental excite- ment, or more frequently, mental depression exists. In such cases inference leads us to expect attacks of vertigo. Paralysis of muscles of deglutition following diphtheria. Acute Alcoholismus.—According to its pathogenetic effects, gelsemium presents symptoms closely analogous to alcoholic intoxication. There is the cerebral congestion, fulness of head, hot and flushed face, blurred vision, difficult articulation of words ("thick tongue"), dryness of buccal cavity and throat, vertigo, and finally, a general feeling of intoxication. In the state succeeding a debauch the indicative symptoms are mental depression, headache, vertigo, confusion of vision, tremulous weakness, dryness of mouth and throat, nausea and even vomiting. Neuralgia.—Neuralgic pains may be present in almost any part of the body. They are acute, or sometimes dull. Pain in the eyeball with headache is often severe, the peculiarity being the aggravation from moving the eyeballs. The cause of these neuralgic pains is probably pressure of the congested venous capillaries upon the nerves. Diplopia and other visual derangements dependent upon asthenia of the ocular muscles, are a frequent effect of the drug. Strabismus may also exist from lack of innervation of the muscles; the cause of which may be debilitating zymotic dis- eases, among which diphtheria may be suggested. Ptosis is also prominent, and may exist conjointly with general asthenopia. When it follows diphtheria, the drug may prove useful. Blindness has also been produced, but its pathology is obscure. Its cause may be pressure upon the optic nerve from deep-seated congestion. Gastralgia accompanied by nausea, headache with indistinct vision, disagreeable taste in the mouth, yellowish fur on the tongue, and other indicative concomitants. 256 GELSEMIUM SEMPERVIRENS. Diarrhoea.—Stool yellow, "bilious;" pain in abdomen, which may be sharp; emission of flatus. Intermittent Fever.—There is chill, fever and sweat in regular sequence. The chilliness lasts at least an hour, with feeble pulse and heat and pain of head. This is followed by general heat, mostly about head and face (the pulse now becoming full), succeeded by profuse perspiration, with con- comitant thirst and languor. If yawning, pains in limbs, and confusion of vision be present, the indications will be strength- ened. Typhoid Fever.—The patient is dull and stupid, and in- clined to sleep; has the feeling and appearance of one intoxi- cated. There is headache with heat of head and face, the latter also flushed; visual accommodation deranged; dry mouth, irregular breathing, pulse weak and rapid, and great prostration. Measles.—Gelsemium produces a rash somewhat similar to that of measles. The drug should be studied for other symp- toms of the disease. Myalgia.—Pains is the muscles of the limbs are quite fre- quent; there is also loss of power in the arm muscles. The pains may be deep-seated and aching, drawing and cramping, or shooting. Rheumatism is therefore suggested. GLONOINUM. 257 GLONOINUM. (Nitro-Glycerine.) REMARKS ON PROVINGS. The provings of glonoin were all made with strong prepara- tions; either the crude drug or the first, second and third dilu- tions; three of the provers using pellets moistened with the first decimal dilution. Three instructive provings resulted from merely touching the tongue to the crude liquid. It is not always easy to distinguish between a proving and a case of poisoning with glonoin. In but one of the cases, how- ever, did a fatal result ensue—a man who took two swallows of "blasting oil." Nearly all of the provers were promptly and decidedly affected, and the symptomatology brings out in bold relief the salient features of the drug and furnishes an unusually clear-cut picture of drug-effects. GENERAL SPHERE OF ACTION. From a study of the action of glonoin on the system it is evident that its effects are produced almost entirely on the nervous and the circulatory apparatus. Were judgment to be based only on the rapid action of the heart so quickly induced, the effects of the drug might be thought to be caused by stimulation of the cardiac ganglia; but certain experiments on animals, together with the immedi- ate response of the system to the drug, lead to the belief that it acts as a sedative upon the pneumogastric nerves, or else, to a certain extent, paralyzes their action, the result being increased rapidity of heart beat. It is remarkable that while cardiac action is greatly increased, even to a violent extent at times, there is no general or even 258 GLONOINUM. local flushing of the skin. There is, however, a strong de- termination of blood to the head. The brain certainly receives more blood than usual, and it is forced through this organ in strong pulsations. The remarkably short time required for the effects of glonoin to appear—often less than thirty seconds—suggests the thought that this substance, like others perhaps, is absorbed by the mucous membrane of the mouth and affects some of the numer- ous nerves there. This influence is carried to the nerve centres and thence reflected to various parts of the body. That glonoin produces a decided effect upon the central nervous system is indicated by confusion of mind, disturbance of equilibrium, convulsions and unconsciousness. SYMPTOMATOLOGY. (Provers, thirty-two: men, twenty-six; women, six.) GENERALITIES. Disturbance of equilibrium2. Convulsions2. Unconsciousness4. Restlessness2. General feeling of sickness2. Lassitude4. Fatigue'". Loss of strength3. Pulsation of heart felt throughout the body3. Recurrence of symptoms3: on the following day2. Effects quickly produced27: in one minute or less9. MIND. Confusion of mind6: "confusion of ideas"2; uncertain where he was2. Unconsciousness4. HEAD. Confusion of head2. Vertigo8. GLONOINUM. 259 Headache27. Character of pain: intense10; dull2; throbbing5 (in the temples3); shooting pain in the temples5. Headache accompanied by a feeling of weight4: in the fore- head2. Location of pain: forehead9 (over the eyebrows4); in the temples9 (throbbing4, shooting5); vertex3; occiput5. Headache increased by motion9: by shaking the head6, lean- ing downwards2, walking3. Relieved by strong pressure2. The head feels full and congested8: chiefly in the sinciput2; with a sensation as if the head would burst3. Head feels sore2. Throbbing in the head15: accompanied by swelling of the blood vessels of the head and neck4; throbbing of the temporal arteries5, most severely felt in the temples3. Headache followed by throbbing5; throbbing followed by headache4; both headache and throbbing felt at the same time6. EYES. Pain in the eyes4. Vision indistinct3: hearing also affected2. EARS. Hearing and vision indistinct2. FACE. Pain in the malar bones2. Convulsive action of facial muscles2. Paleness of face4. Sensation of heat4. MOUTH. Mouth excessively dry3. Tongue felt swollen2. STOMACH. Loss of appetite2. Thirst2. Nausea8: relieved by eating2. 260 GLONOINUM. ABDOMEN. Pain in the abdomen3: griping2; located in hypochondria3 (left2). Flatulence2. STOOL, ETC. Diarrhoea5: loose4; copious2; with pain and feeling of sick- ness2. Discharge of flatus2. RESPIRATORY ORGANS. Inclination to breathe deeply2. Stertorous breathing2. CHEST. Constricted feeling in the chest2. Sharp, cutting pains in the chest2. HEART AND PULSE.* Disagreeable sensation about the heart2. The action of the heart quickened22; violent5; irregular (palpitation)7; variable (rapidity alternating with slowness)3. Rapidity with throbbing of arteries5 (felt all over the body5); with throbbing in the head2. Pulse full4; feeble2; slower than normal2. Effect upon the heart observed in from one to five minutes after taking the drug11. NECK. Pain in the neck2. Stiffness2. Sensation of a band drawn tightly around the neck2. LIMBS. Pain in the legs4: under the patella2. Slight pain in the arms3. * In this group are included also the provings of seven individuals (see Sec. No. 29 of Cyclopaedia), in whose cases the action of glonoin upon, the heart only is recorded. GLONOINUM. 26l SLEEP. Uneasy sleep3. FEVER. SWEAT. Sensation of heat4. Perspiration2. AGGRAVATIONS. Pains increased by motion10: pain in the head9 (shaking the head6, leaning downwards2, walking3); in the limbs while walk- ing3 ; pain increased by ascending stairs rapidly2. AMELIORATIONS. Symptoms lessened in violence while in the open air2. Nausea removed by eating2. THERAPEUTIC APPLICATION. Glonoin is a remedy having especial influence over two im- portant organs—the head and the heart. While its application is limited its characteristics are marked and unique; its con- geners being belladonna and amyl nitrite. Headache.—Glonoin is useful in headache when congestive in character, preceded or accompanied by severe throbbing in the head, felt most severely in the temples. The pain is greatly increased by motion, such as shaking the head, leaning down and walking. The arteries of the neck and temples are dis- tended and may be seen to pulsate strongly. The head feels full and congested, especially in the anterior portion, with a sensation as if it would burst. The character of the pain is throbbing and intense, with a sensation of weight, worse in the forehead. The pain is felt throughout the head, but is particularly severe in certain localities. Thus it is said to be most intense in the forehead, especially over the eyebrows; in the temples where the pain is throbbing or shooting; in the vertex and in the occiput. 262 GLONOINUM. With these sensations are observed confusion and vertigo, the head feels sore. In headaches due to menstrual derangements glonoin is efficacious when there is a strong tendency of blood to the head. Such attacks are often observed to follow suppression of the menses from any cause, and are accompanied by intense and often throbbing headache, with more or less disturbance of mental functions. Sunstroke often demands glonoin. It would appear to be most applicable to those cases in which there is increased rapidity of heart action and evident excitement of the circu- latory system, but with pale and sometimes cool surface. The patient is unconscious and may have convulsive seizures. Such cases are not uncommon and are more of an enigma in respect to proper treatment than those with flushed skin, in which the evident indication is to cool the body by the quick- est method. In both of these varieties of insolation glonoin may be em- ployed successfully. Whenever there is an unusual tendency of blood towards the brain—any form of cerebral congestion—glonoin affords relief. Thus it may be given when apoplexy is threatened, the patient complaining of fulness and beating of the arteries, vertigo and mental confusion, especially when familiar surroundings are not recognized. The fatal attack may sometimes be thus warded off. In angina pectoris and affections of the heart characterized by rapid, violent or irregular action, glonoin is to be relied upon. The pulse is full and bounding, at one time more rapid than normal, and at another slower. IHAMAMELIS VIRGINICA. 263 HAMAMELIS VIRGINICA. REMARKS ON PROVINGS. Few really careful provings have been made of this valuable drug; those conducted separately by Drs. H. C. Preston, W. H. Burt and Wallace McGeorge giving the best results. Dr. McGeorge kept a record of the effects of hamamelis on sixteen persons, and this was published in the report of the American Institute of Homoeopathy for 1874. Twelve of these provings have been made use of in the following symptoma- tology. In addition to the fourteen mentioned, seven provings have been taken from other sources, and from the study of all these provings an epitome of the effects of hamamelis on the human system has been made. Two of the provings were made with "Pond's Extract;" one with fluid extract; seven with the tincture; seven with the third dilution, and four with the sixth dilution. GENERAL SPHERE OF ACTION. Hamamelis is not poisonous, even in large doses, although it may cause serious symptoms. From a study of provings, it appears that hamamelis causes pain and soreness in the larger muscles of the extremities, but has also an influence on the mucous membrane in certain locations and little, if any, in others. The most distinct peculiarity of this drug, however, appears to be its effect on the circulation; i. e., causing hemor- rhages. This probably results from congestion of the mucous membrane so intense as to allow the blood to exude, and it is then carried to the exterior, producing the epistaxis and bleed- ing from the uterus, noted by provers. 264 HAMAMELIS VIRGINICA. SYMPTOMATOLOGY. (Provers, twenty-one: fourteen men, five women, a boy of thirteen and a girl of eleven.) GENERALITIES. General lassitude3: feeling of weariness2. Profuse hemorrhages5. MIND. Depression of mind3. Cross and irritable state2. Can not compose the mind to read or study5. Weakness of memory2. HEAD. Vertigo6: aggravated by rising to an erect posture3. Headache8: in the frontal region5 (over right eye2); dull5; very severe4. NOSE. Coryza3. Epistaxis2. THROAT. Dry feeling in the throat3: momentarily relieved by drinking water2. Sore throat3: causing pain in the effort to swallow2. A sensation of rawness in the throat, felt especially about the fauces4. STOMACH. Thirsty towards evening2. Nausea4. STOOL. Stools covered with mucus2. Constipation2. HAMAMELIS VIRGINICA. 265 URINARY ORGANS. Frequent urging to urinate5; urine clear3; copious5. MALE SEXUAL ORGANS. Severe pain in the testicles3: pain running down the sper- matic cord into testicles2. Seminal emissions3. FEMALE SEXUAL ORGANS. Active uterine hemorrhage2. BACK. Severe pain in lumbar region2. LIMBS. Pains felt in the upper arm6: apparently in the humerus3; in the muscles3 (right side2, both sides2). The veins of the lower extremities are painful3: especially in the thigh2. Pains in the muscles of lower limbs4: aching2. The knee-joint is painful2; the toes4 (right great toe3). SLEEP. Restless sleep3. CHILL. FEVER. Chilliness2. Slight fever2. THERAPEUTIC APPLICATION. Hamamelis is a useful remedy in hemorrhage, and while there is little in the symptomatology to suggest the variety 01 hemorrhage, yet there is enough to justify the opinion that the flow is active and the blood arterial. There is no proof of the "passive, venous hemorrhage" which is usually credited to hamamelis. The localities especially affected appear to be the 266 HAMAMELIS VIRGINICA. nasal membrane and the uterus, but there can be little doubt of its usefulness wherever bleeding comes from a mucous surface. Hamamelis will also be found useful in catarrh, varicosis, hemorrhoids, urinary difficulties and orchitis. HYDRASTIS CANADENSIS. 267 HYDRASTIS CANADENSIS. REMARKS ON PROVINGS. The following reliable symptoms of this remedy have been obtained by winnowing the published records of eight provers thereof, which are found in the Cyclopaedia of Drug Patho- genesy. All of these provers took sufficient of the drug to leave no doubt as to the genuineness of the symptoms produced, the quantity and strength ranging from 10 grains of the powdered root, or 300 drops of a strong tincture, to pellets saturated with the first dilution. All the provings were made in America, and the records kept in the English tongue, so that nothing has been lost or misinterpreted through translation. GENERAL SPHERE OF ACTION. Hydrastis is an irritant of the mucus membranes, acting chiefly through the ganglionic nervous system. It affects mainly the mucous membranes of the body, to wit: The ali- mentary canal and the superficial membrane of the nose and throat. Although said to be of repute in affections of the lymphatic glandular system, the provings do not elicit any such action. SYMPTOMATOLOGY. (Provers, eight: men, six; women, two.*) *Although it is our rule to admit no drug for study that has less than ten experimenters, yet we have made an exception in the case of hydrastis, be- cause of its widespread use, and because even these few records prove the homoeopathic relation of the drug to derangement of the mucus membrane. 268 HYDRASTIS CANADENSIS. HEAD. Dull, heavy, frontal headache2. Sharp cutting pains through the temples2. NOSE. Nostrils stopped up2. Constant coryza4. MOUTH. Bad taste in the mouth2. Aphthous sores in buccal cavity4: lips3. THROAT. Irritability of mucous membrane of pharynx2. STOMACH Sense of discomfort in epigastric region3: pain in stomach2. ABDOMEN. Cutting pain in the umbilical region2. Griping in the bowels3. STOOLS. Number of stools increased3: light colored, with griping the bowels2. Stools soft2. SEXUAL ORGANS. Male.—Pain in the testicles2. RESPIRATORY ORGANS. Increased bronchial secretion2. CHEST. Constriction in the chest at sternum2. NECK. Aching and soreness of muscles of the neck2. HYDRASTIS CANADENSIS. 269 LIMBS. Rheumatic pains in left elbow3; in right hip2; in knees3. SKIN. Irritative action upon the skin of the body in various parts thereof, but not uniform3.* SLEEP. Better sleep than usual3. Sleep disturbed and restless2. THERAPEUTIC APPLICATION. Although in the above provings the action of hydrastis is confined to some definitely named mucous surfaces, we may safely reason from analogy (and experience has corroborated the assumption), and confidently prescribe this drug in simple catarrh of any mucous tissue. It has a controlling influence over chronic catarrh of mucous membranes wherever situated. The dull heavy frontal headache of this remedy will prob- ably be found associated with catarrh of the bile ducts; the sharp cutting pain in the temples may possibly be found as a concomitant of acute or chronic catarrh of the frontal sinuses or nares. The reputed power of hydrastis in curing or alleviating pathological conditions of other tissues than the mucous mem- branes or skin is not substantiated by the recorded provings of the plant, therefore, we can not recommend this remedy in affections to which it is so often applied, to wit: Scirrhus * Expressed as follows: "Intense itching in various parts of the body." " Erysipelatous rash covering neck, palms and joints of fingers and wrists." "The irritation was maddening with intense burning heat, this lasted six days, and then the skin exfoliated.'' "Pimples appeared around the mouth and chin resembling early stage of smallpox, next day they began to vesiculate and two days later to sink in the centre, turn dark and commence drying, scaling off four days later on " 19 270 HYDRASTIS CANADENSIS. sarcoma, epithelioma, lupus, etc. But when the mucous membrane in part or parts of the body is inflamed, and from such inflammation increased secretions are being thrown off, we may expect good results from the use of hydrastis given internally and applied locally. In cases of acute erysipelas attended as it often is with severe biliary and duodenal catarrhal symptoms, hydrastis should be found efficacious, as every experienced practitioner knows that this disease, apart from the skin manifestation, exhibits the symptoms of what is familiarly known as "bilious fever." KALI BICHROMICUM. 271 KALI BICHROMICUM. REMARKS ON PROVINGS. The provings grouped in the Cyclopaedia of Drug Patho- genesy under the title Chromium include those made with chromic acid, chromic sesquioxide and bichromate of potash, more familiarly knows to us as kali bichromicum. Of these provings only those made with the last-named salt are used in this study. The first eighteen provings were conducted by Dr. Drysdale, all except the last using a solution of five grains to the ounce, taking from one to one hundred drops several times daily, for periods varying from several days to three weeks. The last proving of the series, by Dr. Norton, was made with the first trituration. The next section (No. 22) records the results of inhaling the drug while it was being triturated. Then follows a group of eleven provings—the "Austrian provings"—six of which were made with the first trituration, and the others with the second and third triturations or dilu- tions. The "Austrian provers" have become world-famous for the thoroughness and heroic character of their work, and their provings of this drug are exceedingly valuable. The effects of the drug on twelve chrome workers, whose duties required them to handle the bichromate, are utilized, care being taken to eliminate all strictly local effects. Among these forty-two provers were men, women and children. A few sections in the Cyclopaedia were omitted: No. 26, Dr. Marenzeller's proving, on account of his being subject to pul- monary catarrh with chronic mucous discharge from the bron- chial tubes, and to rheumatoid pains. No. 34, Dr. Zlatarovich, 272 KALI BICHROMICUM. omitted because apparently containing many symptoms not caused by the drug. It is a matter of both interest and satisfaction that, after a critical examination of kali bichromicum, its well-known char- acteristic features remain prominent, affording evidence not only of the careful manner in which its proving has been con- ducted, but also the value and accuracy of the present method of materia medica revision. GENERAL SPHERE OF ACTION. Kali bichromicum presents a peculiar individuality, and while it affects decidedly only a few sets of organs, yet upon them it leaves a marked impress. A slight influence over the circulation is indicated by chilli- ness or increased heat of body and perspiration, these symptoms being often intermingled; but the drug selects as its chief field of action the mucous membrane, the skin, the fibrous tissues and the glandular system. Its influence over the mucous membrane is noticeable in both the respiratory and alimentary tracts. In the former there is produced an inflammatory condition of the membrane along the entire tract, from the nasal cavities to the bronchi, accompanied by redness, swelling, pain, dyspnoea and the pro- duction of quantities of tough phlegm. In the fauces and nasal cavities this condition may advance to ulceration, which has frequently occurred on the septum narii. The part of the alimentary tract most affected by kali bichro- micum is the stomach, shown by offensive taste in the mouth with impaired appetite, thirst, burning pain in the stomach, eructations, headache, nausea and vomiting. Post-mortem examinations confirm this. The lower alimentary tract also feels the disturbing influ- ence, exhibited by distention and rumbling, painful sensitive- ness to touch, diarrhoea, and again constipation. KALI BICHROMICUM. 273 When the effect upon the fibrous tissues is studied it is found that scarcely a joint escapes. Pain is felt along the spinal column from the neck to the sacrum, from the shoulder to the phalanges, and from the hips, through the joints, to the toes. The pains partake of the aching, tearing, shooting character of those felt when the fibrous tissue is inflamed. There is evi- dence also that the periosteum is affected. Severe tearing and shooting pains in the hepatic region indicate that an influence is exerted over the liver, as do also heaviness and pain in the head, vertigo, bitter taste in the mouth. An increased flow of saliva seems also to imply unwonted activity of the salivary glands. SYMPTOMATOLOGY. (Provers, forty-two: men, thirty-three; women, seven; a girl of fourteen years and a boy of four.) GENERALITIES. Anaemic appearance with emaciation2. Restlessness'. Languor4. Disinclination to exertion5: with languor2. Lassitude3. Weakness3: exhaustive4; excessive2. Prostration5: with desire to sit down2; with a feeling as if illness was impending2. Throbbing sensation throughout the body2. General rheumatoid pains4. MIND. Ill humor2. Despondency3; gloomy mood3; melancholy2. 274 KALI BICHROMICUM. HEAD. Confused sensation in the head5. Vertigo11: followed by nausea2. Heaviness of the head3. Headache21. Character of the pain: shooting6; heavy5; dull4; heavy and dull3; pressive4; violent3; " darting or aching on one side of the head"3; throbbing2. Location of the pain: on small spots3; on one side of the head5; in the frontal region11 (over the left eye4); in both frontal and occipital regions2; in the temples6 (both sides2, right2, left2; pain of shooting char- acter3) ; on the vertex2. Headache increased by stooping and relieved by rest2. EYES. Inflammation of the eyelids3. Eyelids oedematous on waking'. Injection of conjunctiva3. Lachrymation4. Burning sensation in the canthus3. Pain in the eye7: pressive3; smarting2; the eyes feel hot4; pain located in the eyeball6. The tunica sclerotica colored reddish yellow3. Obscuration of sight6: "dim"4; "confused and dim"3. Itching of the eyes2. EARS. Earache2. Abnormal sounds in the ear3. NOSE. Swelling of the nose2. The external borders of the nostrils inflamed2. Tickling sensation in the nose2. Interior of the nose inflamed4; ulceration of septum3. Obstruction to breathing6: without discharge2. Discharge from nose6: of thick mucus2. Epistaxis4: from right nostril3; frequent attacks3. Frequent sneezing2. KALI BICHROMICUM. 275 FACE. Pain in the face5: in the cheeks2; in the lower jaw2. Eruption on the face2. Face pale4; flushed2. MOUTH. Toothache2. Gums affected2.* Tongue coated6: thickly4; yellow3; coated at the base2. Tongue dry and red2. Increased flow of saliva8. Taste offensive6 (nauseous2); metallic5 (sweetish2, coppery2); bitter3; sour2; saltish2; taste as of blood2. Dryness of the mouth3. THROAT. Sore throat9: with difficulty in swallowing4; rawness2. The throat looks inflamed5; about the tonsils4. Ulceration of the throat central on the tonsils2. Dryness of the throat4. Painful sensations7: scraping4 (causing cough2); burning2. Accumulation of phlegm in the throat4: tough in character3. Sensation as of a plug in the throat2. STOMACH. Appetite impaired7: loss of appetite3; disgust for food3. Thirst6: excessive4. Eructations10: flatulent3; acid2. Nausea18: with vomiting10; relieved by eating2; increased by moving about2. Matter vomited: brownish2; light yellow3; bitter2. Pains in the stomach11; sore feeling3. Pressure in epigastrium3. Sensation of heat in the stomach6: burning3. Gastric derangement6: with distention of the stomach3. Sinking feeling in the epigastrium3. * '' Gum much affected ; of very livid color." " Decided irritation of gum . . . somewhat inflamed." 276 KALI BICHROMICUM. ABDOMEN. Pain in the hepatic region7: shooting pain5; tearing3. Pain in the hypogastrium3: sharp and piercing2. Aching feeling near the umbilicus2. Painful sensations in abdomen: griping6; shooting2; pain followed by loose stool3; leaving the abdomen sensitive to touch2; becoming worse on inspiration2. Borborygmus5: with distention2. STOOL, ETC. Painful sensations at anus3: smarting2. Tenesmus3. Diarrhoea7: dark-colored stools2; pasty2; watery2. Constipation10: lasting during the proving4; stools hard3. URINARY ORGANS. Pains in the renal region5. Frequent micturition4: with burning in the urethra2; burn- ing after micturition3. Urine scanty, depositing a white sediment2. High-colored urine*. SEXUAL ORGANS. Tendency of menses to appear too soon3: pains as if the menses would appear2. RESPIRATORY ORGANS. Uncomfortable sensations in the larynx4: scraping2. Hoarseness2. Cough9: caused by irritation in the throat3 (scraping2); dry cough3; repeated attacks2; with expectoration of mucus7 (tough2, dark3, slaty2, yellow3). Dyspnoea7: caused apparently by a constricted feeling around the waist2; with oppression2. CHEST. Pain in the chest13: right side4; left4; near the sternum4; KALI BICHROMICUM. 277 about the heart3; pain passing from front to back2; at the in- ferior angle of the scapula2; stitch-like pain4. Pains felt in the mammae4: transient2. Tightness of chest3: oppression4. Chest pains increased by deep inspirations3; pains compel deep inspirations. NECK AND BACK. Pain in the neck2. Pain in the back14: in the dorsal region4 (acute pain under the scapula3); in the lumbar region7 (extending down the thighs3; sufficiently severe to arrest movement2); pain in sacral region3. LIMBS. Feeling of weariness in the extremities4. The arms feel weak2. Pains felt in the shoulder4 (tearing2); upper arm2; elbow4 (left2); left wrist2; fingers3. Aching pain in hip-joint3. Pains felt in the lower extremity4. Pains in the thigh3 (shooting downward2); knee3 (sudden2); above the ankle4 (as if in the tibia3); in the heels while walk- ing2; in the toes5 (throbbing2). SKIN. Pimples2. Boils3. Pustular eruption5: on hands3; arms and belly2. The eruption began as vesicles on a red base, becoming pustular, and forming a scab, under which is a dry ulcer, pre- senting a hollowed appearance, healing in from two to four weeks, and leaving a depressed, white cicatrix2. Pains felt in the skin2. Itching2. SLEEP. Drowsiness in the daytime6. Restless sleep8. Dreams6: vivid2; "frightful"2. 278 KALI BICHROMICUM. CHILL. FEVER. SWEAT. Chill2; chilliness3. Feeling of cold4: in the back2; shivering6. Sensations of heat and chilliness intermingled3. Feverishness3. Increased heat of body5. Sweat4. Chill, fever and sweat all present3; sweat preceding the chill and fever2. AGGR A V ATION S. Headache increased by stooping2. Pain increased by motion7: in the ribs2; in the right hypo- chondrium2; by deep inspiration2. AMELIORATIONS. Pain relieved by rest3; headache2. Pains relieved after eating3. Feels better in the open air2. THERAPEUTIC APPLICATION. Rheumatism.—Among general diseases, it would seem that rheumatism should be under the control of kali bichromicum, inasmuch as in its symptomatology may be found many of the characteristic symptoms of this disease. There is a general disinclination to exertion; a feeling of lassitude and weakness, with rheumatoid pains; besides which, pains are felt in nearly all the joints, being especially severe in the loins, often extend- ing down the thighs, but felt also in the cervical, dorsal and sacral regions. The upper limbs feel weary and weak. Pains are felt in the shoulder, tearing in character, upper arm, elbow, wrist and fingers. Aching occurs in the hip-joint, although pain extends through the entire length of the lower limb. Certain localities seem to suffer more acutely than others, as the KALI BICHROMICUM. 279 thigh, down which pains dart, the knee, the calves, the heels, and in the toes, which throb. When rheumatism attacks the chest, kali bichromicum may relieve. Pain in the chest is a frequent symptom; on both sides, near the sternum, about the heart, between the scapulae, and passing from front to back, stitch-like. These chest pains are increased by deep inspirations, and yet it seems necessary to breathe deeply. With this group of symptoms are tightness of the chest and oppression. Syphilis.—One must notice, 111 studying the effects of this drug on the system, their resemblance to some of the symptoms of syphilis. The throat, on examination, appears inflamed, bearing ulcers on the tonsils. Then, too, some of the latter phenomena of this disease have their counterparts in this remedy. Ulcers on the mucous membrane and on the skin; pains in the limbs and apparently in the bones. Like syphilis, this drug touches the deeper tissues of the body, and its effects are long-lasting. Variola.—Any eruption of the skin which presents the fol- lowing group of symptoms points toward this remedy. It will doubtless be noticed how close is the resemblance to variola, in which disease good results should be obtained if adminis- tered after the subsidence of fever. Pustular eruption on hands, arms and belly; began as vesi- cles on a red base, becoming pustular, forming a scab, under which is a dry ulcer, presenting a hollowed appearance, heal- ing in from two to four weeks, and leaving a depressed white cicatrix; itching. Headache.—Just one-half (21) of the provers of kali bichro- micum were affected by headache. The pain is usually shoot- ing, but at times simply aching, or dull, pressive or throbbing. Usually the pain is felt in the frontal region, appearing central over the left eye. It may be felt at the same moment in the frontal and occipital regions, or on one side of the head only, in which case the pain seems to be most severe at the temples. The pain may appear in circumscribed spots. 28o KALI BICHROMICUM. Ocular Troubles.—There is abundant evidence that in affec- tions of the eye kali bichromicum should be of service. The eyelids are inflamed and oedematous, with injection of the con- junctiva and a reddish-yellow discoloration of the sclerotic coat. Lachrymation is usual, and there is a burning sensation in the angle of the eye and also in the eyeball. The pains, felt usually in the eyeball, are described as pressive or smarting, and the sight is obscured and confused. When the eye affection is secondary to rheumatism, and the above symptoms are present, this remedy is valuable and reliable. Coryza.—Use in acute coryza when the nose is swollen and the borders of the nostrils inflamed, as is also the mucous lin- ing. The discharge is not abundant, but is thick and tough. Epistaxis frequently occurs; obstructed breathing; frequent sneezing. Catarrh.—In chronic coryza use when the inflammation of the mucous membrane has progressed to ulceration, especially of the septum. The discharge is usually thick and tough, and yellow in color. Ozcena.—The remedy is valuable also in ozcena, and in diphtheria when it invades the nasal cavities. Kali bichromicum is of excellent service in catarrhal affec- tions of the pharynx, larynx and trachea, but seems to affect the bronchi and lungs but little, lacking the febrile symptoms which usually accompany pulmonary disorders. Angina.—In the upper tract a raw and sore feeling in the throat, with difficulty of swallowing, persists, accompanied by burning, scraping and other painful sensations. The pharynx is inflamed, and ulcerations near the fauces may appear. There is a feeling of dryness, with a sensation as if a plug were fixed in the throat. Bronchitis.—In the lower respiratory tract there is an un- comfortable sensation in the larynx, with hoarseness. Re- peated attacks of dry coughing occur, apparently caused by irritation in the fauces. The expectoration is of tough yellow or slaty mucus. Oppression is felt, together with dyspnoea, KALI BICHROMICUM. 28l caused apparently by a constricted feeling around the waist. There is decided fever, sensations of heat and chilliness being intermingled. Membranous croup, with such symptoms, should be con- trolled by this remedy, its place being probably secondary to some more active drug, and its effect being to soften the exu- date and facilitate expulsion after the virulence of the disease has, in a measure, been controlled. Kali bichromicum seems to have an affinity for the right hypochondrium, producing marked uneasiness and pain, and should not be forgotten in affections of the liver. Diseases of the Urinary Tract.—The effect of this drug upon the urinary tract is decided, its influence extending from the kidney to the extremity of the urethra. In catarrhal conditions of the ureter, bladder and urethra, when characterized by scanty and high colored urine, causing burning in the urethra during and after micturition, and which deposits a white sediment; improvement should follow the em- ployment of kali bichromicum. It is, however, not only when excretory passages are afflicted that this remedy is indicated. If the pain in region of the kidneys be taken into consideration, together with the scanty, high colored urine, depositing sediment, and if the effects of the drug upon the kidneys in cases of poisoning be studied post mortem, there evidently exists a degree of renal irritation which, under favorable circumstances, will develop into acute inflammation. In the early stages of acute nephritis, therefore, or in the more persistent form that follows scarlet fever, or which occurs during gestation, kali bichromicum lessens renal congestion and assists actively in the cure. 282 KALI CHLORICUM. KALI CHLORICUM. REMARKS ON PROVINGS. In the Cyclopaedia of Drug Pathogenesy are entered seven- teen proving records proper, and eighteen records of poisonings from kali chloricum, making in all thirty-five records of sup- posed effects of the drug. Of these, eleven records have been omitted for the following reasons: No. 6 proving record was not used because the experimenter was subject to rheumatic affections; No. 12 record is clinical; No. 17 is a generalization, which, however, has been used as a foot-note. Of the eighteen poisoning records, thirteen have been omitted because too in- definite, statements of generalized effects, clinical observations, or effects mixed with other agents. The synthesis of effects of kali chloricum is therefore based upon eighteen records in all, fourteen of which are provings proper and four of which are poisonings. GENERAL SPHERE OF ACTION. According to the pathogenetic effects due to the chlorate of potash, we find evidences of disturbance in both the cerebro- spinal and the vegetative nervous systems. The cerebro-spinal system exhibits its disturbance in the general weakened condition of the experimenter, ill-humor, dreams, and peculiar sensations in the facial muscles. The vegetative nervous system manifests its perversion in the modified heart's action, irritation of the mucous membrane of the respiratory passages and of the stomach and intestines. The skin is also involved, as is shown in the eruption which is so strongly marked a feature of the drug's action. And finally the kidneys evidence the presence of the drug by increased excretion of turbid urine. KALI CHLORICUM. 283 SYMPTOMATOLOGY. (Provers, eighteen: men, five; sex not stated, but probably male, eleven; one woman; one little girl.) GENERALITIES. Weakness4: weariness2. MIND. Ill-humor2. Cheerfulness2. HEAD. Confusion of head3. Vertigo2. Headache4: in temporal region2. Congestion of head2. EYES. Sensation of fulness of eyes3: expressed as rush of blood into eyes2. NOSE. Sneezing5; coryza4. Sneezing and coryza3. Epistaxis4. FACE. Perverted innervation of facial muscles4: shown in unnatural sensations2. MOUTH, ETC.* Eruption on lip2. Toothache2. Burning taste2; sour taste2; alkaline taste2. Mucus in mouth increased2. THROAT. Dry throat2. * From eight or more grm. salivation occurred for two to three hours, with saline taste, and salivary glands continued "weak" for five or six days. Record 17. 284 KALI CHLORICUM. STOMACH* Anorexia4. Eructations4. Nausea2. Vomiting3: severe2. Uncomfortable sensations in gastric region7: pain3; sensa- tion of weight, distension, flatulence2; gastritis3. ABDOMEN. Discomfort in hypochondria3: pain2; left hypochondrium affected2; right hypochondrium affected2. Pain in abdomen3. STOOL. "Diarrhoea"2. Hard stool2. Mucous stool2. Pain accompany- ing stool2. URINARY ORGANS.t Diuresis4. Urine turbid3: very turbid2. RESPIRATORY ORGANS.} Cough3. CHEST. Oppression of chest3. Pain in chest2. HEART AND PULSE. Oppression of chest with rapid heart action2; strong heart beat2. Pulse quickened6. Pulse weak4: and slow2. SKIN. Eruption on the skin6: papular5; itching of skin at night *The only constant effect on the digestive function was increased appetite. Record 17. f Isambert found, in his experiments upon himself and others, that kali chlor. was eliminated rapidly and unchanged principally by the salivary glands and kidneys. In high doses it showed well-marked diuretic proper- ties. Twenty grm. daily induced frequent micturition, and slight sense of pain and weight in renal region. Urine during whole time eliminated was strongly acid, and deposited urates abundantly. Ibid. }.A slight alteration in voice was noticed. Ibid. KALI CHLORICUM. 285 followed next morning by appearance of small red papules2; rash on the face2, on shoulder2, on lower limb3 (on thigh2). Itching of skin4: "all over body"3. SLEEP AND DREAMS. Dreams2. Disturbed sleep2. CHILL FEVER. SWEAT. Sensation of coldness5: "chilliness"4. Rigor2. THERAPEUTIC APPLICATION. As with many of our drugs, the symptomatology of potassium chlorate is exceedingly meagre, and in consequence it is im- possible to infer a large number of therapeutic uses for the drug. Coryza.—The indications for kali chlor. in coryza are per- sistent sneezing, with watery discharge from the nose; head- ache of the congestive variety, with sensation of rush of blood into the eyes causing a feeling of fulness. From the congestion of the Schneiderian membrane there may also be epistaxis. The catarrhal irritation is not limited to the nares, but a dryness of the throat and a cough suggest its use in catarrhal conditions lower down in the respiratory tract. Although from clinical experience we know kali chlor. to be an excel- lent remedy in diphtheria, yet in this limited symptomatology we have no further evidence of such a possibility than the quoted indicated for its use in catarrh. So it is with its use in stomatitis and ulcerative conditions generally of the buccal surfaces; there is merely slight evidence of the action of the drug herein. Our symptomatology gives simply a modification of taste and an increase of the secreted buccal mucus. Heart.—The heart is strongly affected by the drug, and as it also interferes positively with the functions of the kidneys we may find kali chlor indicated in kidney affections with weak pulse, either slow or rapid. The latter, however, being more characteristic. In conjunction with this there is sometimes a 20 286 KALI CHLORICUM. sense of oppression of the chest, and in this case the action of the heart is rapid. Asthma.—With the oppressed breathing, weak, rapid pulse, pain in the chest and cough, our attention is called to the pos- sible use of kali chlor. in asthma. Gastritis.—Autopsies of victims of the poisonous effects of chlorate of potash have shown positive inflammation of the mucous membrane of the stomach. The symptoms pointing to this condition are anorexia, eructations, nausea and vomit- ing, sensation of weight, flatulent distention and positive pain in the epigastric region. Diarrhoea and Dysentery.—With an extension of the irri- tation of the alimentary canal will be found abdominal dis- comfort amounting to positive pain, particularly in the hypo- chondriac regions. As a result of this irritation, discharges from the alvine tract will follow, which may be simply of a diarrhceic nature (without special characteristic), or they may be of pure mucus. This latter would show a tendency to dysentery, and with the pain which sometimes accompanies the tendency is even more strongly pronounced. Cutaneous Eruptions.—One of the most prominent effects of the drug is to produce a cutaneous eruption, which is most frequently papular in character. We may, therefore, prescribe kali chlor. in papular eruptions. The itching of the skin which sometimes precedes the eruption, especially if it ac- company gastric irritation, would call attention to this drug in urticaria. This symptomatology gives foundation for the use of chlorate of potash in scarlatina, when we take into consideration the effect of this drug upon the skin, the mucous membranes, the kidneys, and the heart. Nephritis.—This action of kali chlor. upon the kidneys would lead to its use in inflammation, and the indication is possibly at first increased flow of colorless urine, and later a smaller amount of turbid urine. Weakened action of the heart together with general prostration would be valuable concomi- tants. KALI CHLORICUM. 287 So far as the use of this drug is concerned in scorbutus, con- junctivitis, keratitis, and some other affections for which it is recommended, we must await further exhaustive pathogenetic testing before including them among the conditions to which the chlorate of potash may be said to have a priori homoeo- pathic relationship. 288 LILIUM TIGRINUM. LILIUM TIGRINUM. REMARKS ON PROVINGS. In studying the action of lilium tigrinum for this symptom- atology, we have utilized nearly all the records found in the Cyclopsedia of Drug Pathogenesy. The work was, however, originally done before the part of the Cyclopsedia containing lilium was issued, the records as found in the Transactions of the American Institute of Homoeopathy for 1867, 1868, 1870 and 1886 being used. The records added in the Appendix of the Cyclopsedia have more recently been utilized, and the sub- joined symptomatology is therefore drawn from all the availa- ble provings of lilium tigrinum which are extant up to date. The provings are none of them made with any degree of accuracy, although they were all reported by physicians and a number of them were made by physicians. (Dr. Warren's toxic case does not come under this censure.) We do not say this because the provings of lilium have been conducted more carelessly than those of the average drug, but because it is probably a fair sample of the method of proving drugs now in vogue; the earlier provers were even more careless. Dr. Wm. E. Payne first had his attention directed to the possible therapeutic value of the tiger-spotted lily by seeing the report of the death of a child from eating the pollen of the flower. A record of the toxic symptoms of this first victim to the drug was apparently not made, as Dr. Payne does not again refer to it; but a second fatal case, that of a little girl poisoned by an anther of the lily which she had thrust into her right nostril, was reported by Dr. R. T. Warren.* The symptoms from this case are objective, and consequently valu- able. We have, therefore, adopted them all. * If these cases are the same they are unfortunately reported as though two distinct poisonings. LILIUM TIGRINUM. 289 The drug was proved with preparations ranging from the fifth centesimal down to the crude drug. A clinical proving of the thirtieth dilution, found in the Institute Transactions, by a patient of Dr. L. M. Kenyon, we have of course rejected. Likewise, the three hundredth dilution proving of Miss F., also in the Transactions of the Institute, is inadmissible for our purposes; we have, however, utilized this so-called proving as a record of health manifestations preparatory to the proving of the fifth centesimal, and only regret, as there are no health records of any of the other provers, that they did not all antici- pate their provings with a two weeks' course of the three hundredth dilution. The total number of provings of the tiger lily recorded in the Cyclopsedia of Drug Pathogenesy is twenty-three, besides one poisoning case. Of these records we have discarded but three, and these three are students who reported no symptoms. We have, therefore, utilized all the records of symptoms of lilium tigrinum which are noted in the Cyclopsedia, making twenty-one records. GENERAL SPHERE OF ACTION. Lilium tigrinum acts most prominently upon two vital cen- tres : the reproductive and the circulatory. In both sexes the heart is affected, and in both the genera- tive organs; but the.woman is the greater sufferer from sexual derangement. The heart is only functionally disturbed; but the uterus may be influenced to the extent of becoming displaced. Next to the heart and genitals the nervous system is affected. But this is due to reflex action from the heart or sexual centre, as is also the case with other parts of the body that manifest a disturbance. For example: uterine displacement may be accountable for the gastric, the heart, or the head symptoms; and the heart, per se, may cause the limb symptoms and the 290 LILIUM. TIGRINUM. chills, also the constriction of the chest, which latter is due to weak action of the heart and consequent sanguineous stasis. Dr. E. M. Hale says: "A study of the provings does not render it certain which organ, the uterus or ovaries, are first affected. As the ovary is the real centre of the reproductive organs, it is probable that it is really the organ first affected." This we believe probable. It may, therefore, be concluded that lilium tigrinum is best indicated in pathological conditions dependent upon functional disturbance of the heart, in either men or women; or in women, reflex from the uterus or from the ovaries. SYMPTOMATOLOGY. (Provers, twenty: men, eight; women, eleven; one little girl.) GENERALITIES. Languor3. Prostration4: weakness2. Disinclination to either mental or physical work3. Restlessness4. Nervous excitability6. (This is expressed in crossness, restless excitement, or a weak, irritable feeling, according to temperament.) MIND. Mental irritability4. (Shown in peevishness, impatience, uncivil language or swearing, according to temperament, sex, etc.) Mental depression4. (Ranging from indifference to profound depression.) Memory impaired4. Inability to think clearly2. Mental application difficult3; complete inability to apply the mind2. Fear of insanity2. Inclined to lewd thought and conversation2. Surroundings seem unreal2. LILIUM TIGRINUM. 291 HEAD. Vertigo3: with headache2. Headache14: frontal7 (worse on right side3, over left eye3); in side of head6 (left side4, left temple2, right temple2); dull4 (dull frontal3); with sensation of full pressure from within outwards4. Headache worse on motion out of doors2. Heavy feeling in the head3. EYES. Eyes painful3. Dimness of sight3. Blurred vision2. NOSE. Stoppage of nostril2. PACE. Cheek flushed3: the whole face flushed2. Heat of the face at circumscribed points3. Pain in right side of face2. MOUTH. Increased flow of saliva2. Unnatural taste4: bad taste2. STOMACH. Nausea7. Desire to vomit2. Eructations3. Anorexia7. Increased desire for food2; craving special articles2. Discomfort at epigastrium3: empty sensation2. ABDOMEN. Sensation of bearing down in lower part of abdomen3: press- ing downwards and backwards and worse when standing2. Soreness of abdomen3: to pressure2. Rumbling in the abdomen3; sensation of fulness4; trembling sensation2. Pains in the bowels9: sharp in character6; followed by stool5 (which relieves4). 292 LILIUM TIGRINUM. STOOL. Loose stools6: diarrhoea5. Inclination to stool4: "diarrhceic" sensation3. Tenesmus3. Sensation of pressure in anal region3: on rectum2. Escape of flatus5: with the stools4. URINARY ORGANS. Frequent micturition5; increased secretion of urine6 (voided often2); urine scanty3 (and passed frequently2); high colored2; colorless2. Smarting in urethra from passage of urine2. Urine has strong odor2. SEXUAL ORGANS. Male.—Increased sexual desire4: with nocturnal seminal emissions accompanied by erotic dreams2. Female.—Bearing down in uterine region5: as though the contents of the pelvis would issue through the vagina2. Anteversion of the uterus3. Pain in uterine region3; in ovarian region4 (right ovarian region3). Ovarian pains relieved by moderate pressure2. Pelvic pains worse on movement3: ovarian pains worse on movement2. Sexual desire very strong2. Irregularity of the menstrual function4 :* the flow comes pre- maturely2. Acrid leucorrhoea excoriating the parts5. HEART AND CIRCULATION. Labored breathing resulting from rapidity of heart's action3; which latter is unduly caused by rapid movement of any kind2. Palpitation of the heart6: when lying down4. Pain in the .cardiac region7: sharp2, dull pressive2, constrict- ive, as if the heart were strongly grasped2. The pains come suddenly3, and are worse from movement2. *In one case (not included above) a flow of bright red blood issued from the vagina two years after cessation of menses. LILIUM TIGRINUM. 293 A sensation of fulness in the cardiac region, as if the heart were overcharged with blood2. Chilliness in conjunction with cardiac disturbance2. Sensa- tion of twitching in cardiac region'. Weakness of the circulation2. A heavy feeling in the car- diac region2. RESPIRATORY ORGANS. Dry cough2. Sighing2. CHEST. Chest feels too full2. Pains in the chest4: in the left side3; acute in character2. BACK. Pain in the back11: in the lumbar region6; in lumbo-sacral region2; dull in character5; aching3. LIMBS. Tearing pain in left arm2. Pains in fingers2. Cold hands3. Lower limbs feel weak3. Painful sensation in right hip joint2. Pain in thigh4: pains along inner side of thigh3 (of left thigh2). Pain in knees2; in legs2; in ankle joint2; in foot2. Feet cold5: and damp2. Feet tender2. SLEEP AND DREAMS. Unquiet sleep3; disturbed by disagreeable dreams5. Sleep- lessness2. Yawning3: yawning and stretching2. Sleepy2. CHILL AND FEVER. Chilliness6: running down the back2. Rigors3. Chills with cardiac disturbance3: with pain in cardiac region2. Fever symptoms2. AGGR A.VATIONS. Headache aggravated by motion3: and worse from motion in open air2. 294 LILIUM TIGRINUM. Pains in uterine region worse from motion2. Pains in ovarian region worse from motion2. Bearing down in uterine region worse when standing2. Some symptoms worse in the evening3. AMELIORATION. Pain in ovarian region relieved by moderate pressure2. THERAPEUTIC APPLICATION. The conditions in which the tiger lily will be found most frequently indicated are probably uterine displacements, ova- rian irritation, leucorrhcea and irritable or weak heart. Mind.—In mental disturbance wherein the memory is impaired, and there is irritability or great depression and diffi- culty to think clearly, and even fear of insanity, especially if due to derangement of the sexual system. Uterus.—With the uterine mal-position of lilium tigrinum there will be present the characteristic bearing-down pains; the sexual excitement may or may not be present and there may be palpitation of the heart. Headache is present in these affections, of a dull character, with fulness pressing from within outwards. The characteristic displacement is anteversion, with the mechanical pressure upon the bladder which causes frequent micturition. Ovaries.—The ovarian pains are sharp, but may be tempo- rarily relieved by moderate pressure. Either or both ovaries may be affected, but the right is more frequently painful. Leucorrhcea.—With the ovaralgia or with the displaced uterus there is sometimes leucorrhoea; this is acrid and causes excoriation. This leucorrhoea is probably due to the uterine condition. Heart.—The irritable, weak heart of lilium is probably most frequently reflex from the genital organs (in women). There is a feeling of oppression, with a sense of constriction of the LILIUM TIGRINUM. 295 chest; the heart will palpitate violently, which is, of course, aggravated by motion; the breathing is labored, chilliness may be present, also a dull, heavy headache, and the patient may be unfitted for the lightest employment. In men the heart symptoms, per se, are similar. The foregoing are the morbid conditions for which lilium is most frequently prescribed. There are other disturbances to which the drug may be suitable, but these are left for the prac- titioner to detect through a study of the pathogenesis in the light of his practical experience. 296 OPIUM. OPIUM. REMARKS ON PROVINGS. This symptomatology has been drawn entirely from the records found in the Cyclopaedia of Drug Pathogenesy. In the majority of records the crude drug or the tincture has been used, though some experimenters tested the first or second dilution; but the sixth, which was taken in five-drop doses, was the smallest amount of drug used. The largest dose taken without fatal effect was by De Quincey, who reports eight thousand drops of laudanum, or sixteen ounces, five drachms and twenty drops at one dose. The next dose in amount was two and a half ounces of laudanum, taken with suicidal intent by a soldier. Another record which seems worthy of consid- eration is No. 33 of the provings, in which case three drachms of laudanum were rubbed into the leg of a young man. In several of the experimenters no effects were felt from preparations of opium above the sixth dilution; and one prover, No. 28, could detect no symptoms even from the first dilution. Quite a number of records were excluded either in whole or in part from the synthesis, which are as follows: No. 1, Hahne- mann's collection of symptoms, which may be found in the Materia Medica Pura, but which lack data; No. 3b, the symp- toms in the latter part of the record after the tea and lemon were taken; Nos. na, 13a, and 15, because the preparations used are not noted; Nos. 21 and 22, because the few supposed effects noted are from dilutions above the twelfth decimal dilu- tion; No. 33 (which should be numbered 34), because it is a clinical case; and No. 36, because of the strong probability that the drug was used for some morbid condition, and was neither taken accidentally nor for the purpose of ascertaining its pathogenetic effects. OPIUM. 297 Of the cases of poisoning, twenty-two records in all, but seven could be utilized, which were Nos. 3, 4, 5, 6, 8, 13, and 18; the balance were not available because clinical, too indefi- nite, generalizations, etc. The symptomatology, therefore, has been constructed from thirty-one proving records and seven poisoning cases; of which collection twenty-eight were men, two women, one boy, and seven without sex stated, but who were probably men. GENERAL SPHERE OF ACTION. Opium acts profoundly upon both the cerebro-spinal and the vegetative nervous systems. As a result of its interference with the voluntary nervous system we find the mind affected, its intellectual power decreased, memory weakened, and the intellectual sphere may be stimulated but to sink into profound stupor. The emotions are disturbed, and the experimenter may be sad, anxious, or ill-humored. The head gives evidence of the involvement of the physical functions of the brain, in the confusion, vertigo, and pain which is sometimes present. The motor power of the body is affected, and the limbs give expression to this condition in weakness, weariness, heaviness, trembling, and unsteady gait on attempting to walk. The involuntary nervous system gives evidence of its dis- turbance in purturbation of the special senses of vision and hearing, and in the interference with the circulation, the heart's action being more rapid than usual, or in some cases retarded. Throughout the body there is a sense of general turgescence of the blood vessels with general increased warmth of surface, or on the other hand the skin may be cold and damp. At the same time there is interference in the respira- tory function, and the experimenter suffers from oppressed breathing and constriction of the chest. The urinary organs also become affected, and there may be urging to urinate, with 298 OPIUM. difficulty in micturition, or the reverse, an increased flow of water. Last, but not least, the digestive organs become disturbed. Beginning with the dry mouth and perverted taste, and modi- fied appetite and thirst, the stomach feels empty and even painful, the abdomen is distended, is painful also, and with more or less rumbling there develops a tendency to diarrhoea; or, as is more frequently the case, the bowels become consti- pated. The intestinal discomfort extends from the mouth to the anus, for we find the experimenters noting a sensation of decided discomfort at this latter point, and also the more defined sensation of pain, or of burning caused by stool. The general sphere of action, therefore, of papaver som- niferum may be concisely stated to be the mind, the brain, motor nerves, circulation, and digestive organs. SYMPTOMATOLOGY. (Provers, thirty-eight: men, twenty-eight; women, two; sex not stated, but probably male, seven; 1 boy.) GENERALITIES. Weakness23: weariness9; lassitude9; lassitude and weariness5; exhaustion7; prostration4; faintness4. Increased activity2. Restlessness5. Excitement of the whole system2. Trembling2. "Heaviness"2. Unsteady gait2. "Intoxication"2. Probable unusual fulness of blood vessels3. Malaise6: " discomfort"2. * Indications of disturbance of the motor nervous system4. MIND. Mental excitement2. Delightful visions2. Objects did not appear of natural size.2 * Expressed as "sudden jerk through whole body," "voluntary muscles strongly convulsed," and "stiffness of whole body." OPIUM. 299 Distaste for work2. Feeling of indifference4: to everything3; to usual occupa- tions2. Mental depression12: sadness4. Anxiety3. Ill-humor2. Cheerfulness4. Intellectual power decreased12: incapacity for mental effort4; concentration of thought difficult4. Memory weak2. Stupefaction6: insensibility2. HEAD. Confusion of head16. Vertigo14. Confusion of head with vertigo5. Vertigo with headache6. Headache19: frontal9 (right side of forehead2, pressing pain5, stabbing pain2); occipital6 (pressive pain3); in vertex6 (pressing pain2). Character of headache is pressing9, dull3, acute3, throbbing2. Head felt heavy7. "Oppression" of head4. Head felt dull2. Heat of head3: forehead felt warm2. Fulness of head3: "congestion"2. Pressing in head3: in forehead2. Sensation of tension in scalp2. Headache in forehead2. Headache in afternoon7: ceasing in the afternoon3. Headache and stool in afternoon2. EYES. "Pressing" in eyes3. Sensation of heat in eyes2. Eyes dry4: sensation of dust in them2. Redness of con- junctiva3. Increased secretion of tears4. Vision obscured10: dim5, misty3, veiled2, dark2. EARS. Tinnitus aurium5. Dulness of hearing4. 300 OPIUM. NOSE. Discharge of mucus from nose2. FACE. Face pale3. Face red5: cheek red2. Face abnormally warm4: face hot and sweating2. MOUTH. Dryness of mouth3. Tongue coated5. Tongue dry2. Increased secretion of saliva5. Abnormal taste in mouth7: unpleasant5; bitter3. THROAT. Irritation of fauces3. Constriction of oesophagus2.* STOMACH. Repugnance to food3. Hunger3. Appetite impaired.6 In- creased desire for food2. Increased thirst3. Eructations6. Nausea14: nausea and inclination to vomit4; nausea and vomiting2; ineffectual retching2; nausea and eruc- tations5. Pain in stomach5: acute pain2. Sinking feeling in stomach2. Constrictive feeling in stomach3. Feeling of emptiness in stomach4: not relieved by eating2. Sensation of pressure in stomach3. ABDOMEN. Pain in left hypochondrium3. Pain in umbilical region9: "cutting"5, colicky4; followed by evacuation of bowels3; pressing pain2. Rumbling in abdomen4. Pinching in abdomen3: rumbling and pinching2. Abdomen distended4. "Tension" and sensation of fulness in abdomen.2 * The oesophagus was affected in three experiments, but differently in each one. In one it was dry, in one painful on deglutition, and in one spasm of the oesophagus made deglutition difficult. This suggests a tendency of the drug to interfere with the normal condition of the oesophagus, but does not define the character of the interference. OPIUM. 301 RECTUM AND ANUS. Feeling of spasmodic closure of anus2. Pain in anus aggra- vated by touch2. The stools cause burning in anus2. Decided discomfort in rectum3. STOOL. Diarrhoea6. Constipation16: fseces hard8; with great effort3. Stools light in color3: whitish2. Dark stool2. Fseces soft3. Stool less consistent than normal11: liquid5, papy4, liquid and copious2. Stool small7: small and hard2. Stools copious but not liquid3. Stools in the afternoon7: less consistent than normal4; harder than normal2. Stools in the forenoon6: less consistent than normal5. Stool and headache in afternoon2. Pain in abdomen with stool6: cutting pain3. Stools more frequent than usual4. Urging to stool3. Stools cause discomfort at lower end of intestinal tract4: pain2. Flatus passed6: large quantity5; offensive2. URINARY ORGANS. Urging to urinate3: with difficulty in passing urine2. Increased secretion of urine5. Sediment in urine2. Urine darker than normal3. Turbid urine3. RESPIRATORY ORGANS. Cough3. Mucous expectoration2. Oppressed respiration8: "dyspnoea"3. Breathing increased in frequency2. Gasping for breath2. Long, deep breaths2. CHEST. Sensation of constriction of chest2. Pain in chest2. HEART AND PULSE. Increased vascular action3. Pulse slower than normal8. 21 302 OPIUM. * Pulse more rapid than normal19: weaker and quicker than normal4; stronger and quicker than normal3. Pulse weaker than normal6; fuller than normal5. Pulse "large"5; "hard"3; '' large " and " hard "2; " small "3; irregular2. NECK AND BACK. Pain in nape of neck4: pressive in character2. Pain in dorsal region2. LIMBS. Trembling of limbs3. "Heaviness" of limbs2. Tearing, drawing in forearm2; acute pain in wrist2; numb- ness of hand2. Motor power of thigh weakened3. Weariness in knees*. Weakness of legs*; heaviness2; weariness2. Pain in flexure of knee joint*. SKIN. An eruption appears on the skin3: of the hand*; of the thigh*; size of peas*. Horripilation of the skin*. Excessive perspiration7: cold3. Skin cold*. Increased heat of skin8; "skin hot'". Skin hot and blood vessels full*. SLEEP. DREAMS. Somnolence**: yawning2. Inability to sleep3. Sleep unrefreshing7; dreamful6; restless6; "disturbed"2. CHILL. FEVER. SWEAT. Cold skin2. Increased warmth of body9. Sweat increased over whole body9. Heat of face2. General heat and sweat3; heat followed by sweat2. *The greatest number of beats per minute were in poisoning case 3, 126. (Recovered,) The smallest numer of beats per minute were in prover 4 b., 40. OPIUM. 303 AMELIORATIONS. Confusion of head relieved by exposure to air of lower tem- perature2. Coffee relieves general symptoms2. THERAPEUTIC APPLICATION. Mental Derangements.—In mental derangements opium may be considered. The patient is melancholy, sad; or anxiety may characterize the condition. A mild form of delirium is sometimes present in which delightful visions appear, and sur- rounding objects do not seem of natural size. In softening of the brain we should find in opium a means of relief. The in- dications leading to it in this latter affection are, distaste for work, incapacity for mental effort generally, and difficulty in concentrating the mind upon any subject; besides there is indifference to everything, even the usual occupation, and the memory is weakened. Paralysis.—The form of paralysis for which opium seems best suited, according to our pathogenesis, is motor in charac- ter. This is evidenced in weakness, trembling, heaviness, loss of power in the limbs and staggering gait on attempting to walk. In the numbness of the hand we find a suggestion of paralysis of sensation also. Pulmonary" Congestion.—Gasping for breath, dyspnoea, sen- sation of constriction of the chest, cough, weak, rapid pulse, cold, damp skin, and pale face, point to interference in the respiratory apparatus due to overwhelming congestion of the lungs. Digestive Disturbance.—Simple acute indigestion, or even gastritis may be cured by opium. The patient will be found to have increased thirst, repugnance to food, nausea and even vomiting, acute pain in the stomach, a feeling of constriction or a sinking or empty sensation therein. The pulse will be quicker and stronger than normal; and with it all will be a 3°4 OPIUM. somnolent tendency, concomitant with which may be a slight, mild delirium. Constipation is a prominent indication for this drug. The fseces are small, hard, and require great effort to expel them, and when they have passed the anus burns or pains. A sensa- tion of spasmodic closure of the anus is also present. The abdomen feels distended, and with the rumbling of gas, which is offensive and passed in large quantities, there is pain, cutting or colicky in kind. Diarrhoea is not usually considered characteristic of opium, but the drug will prove curative in this condition, given accord- ing to its indications, as certainly as it will for constipation. In cases of acute indigestion, with pains in the abdomen, cut- ting, colicky, nausea and vomiting, dry mouth, copious, liquid stools, large quantities of offensive flatus, stupid tendency, and discomfort at anus caused by the stools; such indications and any other concomitants characteristic of the drug which may be present, will find relief from opium. Typhoid Fever.—In typhoid fever the mind becomes cloudy, with mild delirium, the patient seeing visions of various things; the face may be red, the mouth dry, and the tongue dry and coated, the bowels constipated, the limbs tremulous and v/eak, vision obscured, hearing dull, with possible tinnitus aurium, urine dark and turbid, and abdomen tympanitic. Opium is truly homoeopathic to such a case. Malarial Fevers.—Although opium may not be often indi- cated in conditions arising from the effects of malaria, yet in some cases of this character it may prove useful. The tendency to stupor or sluggishness should call one's attention to this drug; the weak pulse, which, however, is rapid, the tremulous weakness out of proportion to the duration of the sickness, and the profuse perspiration. Opium has produced chill, increased heat and sweat, but while there is no evidence to show that the three stages have been produced sequentially, yet it has produced heat followed by sweat. Although it is not men- tioned, it is probable that a cold stage of greater or less intens- ity preceded the two stages noted. OPIUM. 3°5 Congestive Chills.—When a chill occurs, together with oppressed breathing, pale skin, and with stupor tending to complete insensibility, etc., opium should be prescribed. Headache.— Accompanying the headache of opium, the dulness of the drug almost invariably manifests itself. The frontal region is most frequently affected, and next to this the occiput is involved. The pain is most frequently pressive in character, the head confused, and vertigo is present; vision may become misty and tinnitus aurium appears. If there is anything in the "time" aggravations, then the opium head- ache most frequently occurs in the afternoon. The confusion is relieved by cool air. Conjunctivitis.—This condition may be cured by opium. The eyes are dry, with sensation of dust in them, the conjunc- tive is red, there is a sensation of heat and pressing in the eyes, and vision is obscured. Relative to the bad effects of fright, threatened paralysis of the lungs, laryngismus stridulus, epilepsy, hsemoptysis of drunkards, and many other conditions for which opium is used, we can not find sufficient data in our limited symptoma- tology to justify the assumption of its homoeopathic relation- ship to them. While this relationship may exist, we merely call attention to the fact that we have been unable to detect it, and believe further scientific tests to be necessary to establish it. 306 SANTONINUM. SANTONINUM. REMARKS ON PROVINGS. In all eighteen records of the effects of santoninum are used in preparing this symptomatology; the whole or part of each "proving" in the Cyclopsedia of Drug Pathogenesy is used, and also of the poisonings, except Nos. 12 and 13, which are excluded because the former is too indefinite and the latter is clinical. The following parts of records could not be utilized: Proving No. 2, section "a," consists of generalizations; section "c," "d," "e" and "f" are records of effects of santonate of soda and not santonine; section "g" is a generalized statement and is only suitable for foot notes. Proving No. 4, sections "b," "c" and "d" are santonate of soda records, as is also "b" of Proving No. 5. All the tests were made with doses of the crude drug. GENERAL SPHERE OF ACTION. Without post mortem appearances to guide us the general field of action of this drug is somewhat difficult to infer from the symptomatology alone. The nervous system is apparently the most strongly affected of any apparatus of the body. This is evidenced in the gen- eral convulsions, the ocular disturbance, etc. The digestive organs are irritated, thirst, nausea and emesis, besides pain in the abdomen, pointing to such perturbation. The urinary apparatus is also involved, as is shown in the heightened color of the excretion, the frequent desire to mic- turate, etc. Whether the nervous system is primarily affected, or whether its disturbance is reflex from the digestive organs, we have not sufficient data to decide; but it is certain that both convulsive SANTONINUM. 307 symptoms and visual aberrations were prominent in experi- menters of whom no gastric symptoms are recorded. SYMPTOMATOLOGY. (Provings, eighteen: men, six; boys, seven; girls, three; children of unstated sex, two.) GENERALITIES. Convulsive movements7: convulsions5; clonic3; tonic2. Restlessness4. Apparent loss of vital force7: weakness5; malaise3; exhaus- tion4. MIND. Mental perturbation2. Mental activity impaired6: unconsciousness4. HEAD. Head hot3. EYES. Convulsive movements of muscles of eyes, distorting the eyes6: the eyes roll about2; they are fixed2. Pupils dilated4; insensible to light3. * Yellow vision, i. e., things appear as though seen through a yellow medium8. FACE. Convulsions of facial muscles4. Face swollen2; pale2; con- gested2. MOUTH. Lips swollen2. Saliva issuing from the mouth4: foaming at the mouth3; with teeth clenched2. * Out of thirty human subjects, yellow sight in all; violet sight in nineteen. From Virchow's Archives. 308 SANTONINUM. STOMACH. Thirst2. Nausea5. Emesis5: of viscid matter3; of mucus2. *Nausea and vomiting2. Pain in stomach2. ABDOMEN. Pain in abdomen3; swollen and sensitive2. URINARY ORGANS. Frequent desire to micturate2. Involuntary micturition2. Urine high-colored8: orange-colored4; saffron-colored2. Quantity of urine increased2. Urine became scarlet on addition of carbonate of soda2. RESPIRATORY ORGANS. Respiration stertorous3; hurried2. HEART AND PULSE. Pulse weak4: slow and weak2. Pulse quickened3. LIMBS. Convulsive movements of muscles of extremity4: upper3. SKIN Skin cold2. Covered with cold sweat2. SLEEP. Restless sleep2. CHILL. FEVER. SWEAT. General sweat2. Cold sweat on forehead2. THERAPEUTIC APPLICATION. According to this pathogenesy the therapeutic range of santoninum covers a very small field. * Out of thirty human subjects, nausea and vomiting in fourteen. Vir- chow's Archives. SANTONINUM. 309 Convulsions.—In this trouble very few indications are pre- sented so far as the kind of spasm is concerned. The convul- sion may be either tonic or clonic. The general muscular system is involved, the facial expression is changed, the eyes are distorted, either continuing to roll about or remaining fixed, with dilated pupils which fail to react to light; the patient is totally unconscious; the head is hot, and the skin cold and covered with a cold sweat. Helminthiasis.—When the convulsions follow a condition of general depression of the system, accompanied by swollen, sensitive and painful abdomen, swollen lips, cold, clammy skin, thirst, nausea and vomiting, restless sleep, yellow vision and mental sluggishness, worms may be suspected as the cause and the drug should be prescribed. Epilepsy.—The frothing at the mouth, together with the clenched teeth and the general spasmodic characteristics with dulness of mind, suggest santoninum in epilepsy. Enuresis.—Urine increased in quantity, orange or saffron- colored, with frequent desire to micturate. These symptoms should suggest the drug in nocturnal enuresis. Ocular Troubles.—Where there are spasmodic derangements of the ocular muscles with dilated pupils that fail to react to light, and in visual disturbances with yellow vision, the drug may be used. Chorea.—The clonic variety of spasms produced by san- toninum should lead to its study in chorea. In fact santonine should be studied in any abnormal condi- tion reflex from intestinal irritation due to the presence of foreign bodies, be they indigestible foods or worms. 310 THUJA OCCIDKNTALIS. THUJA OCCIDENTALIS. REMARKS ON PROVINGS. This study of thuja is based on the results obtained by the Austrian Provers' Society as recorded in Metcalf s Homoeopathic Provings, together with an accidental proving by Dr. Dudgeon. The provers, as a rule, employed the tincture prepared accord- ing to the Hahnemannian method, or else used dilutions vary- ing in strength from the ist to the 12th. One of them, Dr. Frolich, recorded the effects of chewing the branches, and also the effects of the fresh juice; another, Dr. Bohm, used the 1st centesimal trituration of the dried twigs; Dr. Mayrhofer proved the tincture and also the oil of thuja, made by distillation of the twigs; and Dr. Dudgeon records the distressing results upon himself of chewing a green cone. The work of the Austrian Provers' Society is remarkable for the persistence and boldness of the provings. The experiment in many cases was continued, although very painful and even alarming symptoms were produced, and the drug was taken in enormous doses. The boldest of the provers, Dr. von Zlatarovich, beginning with six drops of the tincture, increased the quantity to 1,000 drops at a dose, and in one hundred and fifty-five days took 42,260 drops. The quantity taken by Dr. Reisinger and also by Dr. Mayrhofer reached finally two ounces at a dose. It is altogether likely that these enormous doses produced symptoms not to be credited properly to the drug, by reason of local action as well as the presence of alcohol in considerable amount; and study of the reports of the different provers seems to lead to the conclusion that more complete provings would have resulted from the use of the 1st or 2d dilution. None of the experimenters kept a record of health previous to the proving. THUJA OCCIDENTALS. 311 The following symptomatology is made from the records of twenty-six provers, six of whom were women and twenty phy- sicians. GENERAL SPHERE OF ACTION. Thuja, contrary to the usual opinion held of it, has quite a wide range of action, affecting chiefly the nervous and muscular systems and the sexual and generative organs; leaving almost untouched (unless given in massive doses) the alimentary canal, except at its outlets, and affecting the circulation only in the peculiar febrile movement. The influence on the nervous and muscular systems is shown almost entirely by the presence of pains. These are varied in character and location; almost every kind of pain having been felt, and few muscles of the body seem to have escaped these sensations. Like most resinous products, thuja affects the mucous mem- brane of the genito-urinary tract, but seems not to act with sufficient force to affect the larger glands except in a secondary manner, though the smaller ones, which are closely connected with the mucous membrane (i. e., the muciparous, prostate, etc.), feel its influence. SYMPTOMATOLOGY. (Provers, twenty-six: men, twenty; women, six.) GENERALITIES. Great general weakness11. Glandular enlargements2. Pain is felt in small spots5. Character of the pains: stitches25; drawing21; tearing19; draw- ing-tearing4 ; sticking13; burning10; griping8; pressing6; lanci- nating5 (as if from a thrust2); bruised4; cutting4; pinching2; biting2. Periodicity of symptoms5. 312 THUJA OCCIDENTALS. MIND. Gloomy4. Anxious2. Alternations of cheerful and melan- choly moods2. Inclined to be angry2. Ill-humor3. Mental power impaired4.* HEAD. Dulness of head3; confusion4 (dull3). Vertigo8. Headache19: pressing11; stitching7; drawing7; aching6; lan- cinating5 (as if thrust with a large needle2); tearing3; sticking3; twitching2; pain located in forehead12 (frontal eminences6); temples7 (both5, right2); mastoid region3; vertex7; parietal region3; occiput8. EYES. Burning on the margins of the lids6: burning and stinging2. Quivering of the eyelids2. Feeling as if a foreign body were in the eye2. Conjunctiva injected2. Pain in the eyeballs6: burning4; tearing2. Vision indistinct4, f EARS. Pains in the concha of the ear2. Transitory pains in the internal ear3. Abnormal sounds10: buzzing4. NOSE. Breathing through the nostrils is obstructed3. Dryness of the mucous membrane3. Burning sensation in the nose2. Sneezing2. Coryza, with increased secretion4: thin2. Bleed- ing from the nose2. * Expressed as follows: '• Great trouble in collecting his thoughts." '' Want of disposition to do anything." " Intellectual effort soon fatigues.'' " Speaks very slowly and monosyllabically." t Expressed as : " Mistiness of sight.". " Obscuration of sight." " Fail- ure of sight." " Could not see or read clearly." THUJA OCCIDENTALS. 313 FACE. Pains in the side of the face6: transient3. Pains felt in the lower jaw4: running from the angle towards the chin3. The face is pale2. MOUTH. Toothache3. Vesicles on the mucous membranes of the mouth''. A feeling of dryness on the hard palate3. Increased flow of saliva7: profuse4. Variations in the sense of taste6.* THROAT. Hawking8: frequent4; tough mucus2. The throat feels rough5, dry3, sore2, constricted2. Scraping in the throat3. Deglutition painful3. STOMACH. Appetite lessened6: lost2. Canine hunger3. Increased thirst2. Eructations3: frequent2. Nausea5: disposed to vomit4. Pains in the stomach8; pressure5. ABDOMEN. Pains in the hypochondriac region4: stitching2. Painful sensation in the abdomen13: griping pains about the naval2; pain in the right iliac region2; colicky pains3; parts sensitive to pressure3. Distention of abdomen4. RECTUM AND ANUS. Itching about the anus7. Pains about the anus11: burning4; pressing2; stitching4. Enlargement of rectal vessels3. * Expressed as follows: "The taste was insipid." "Nauseous taste." " The taste was injured by increased flow of saliva ; the food tasted as if not salted enough." " Very unpleasant sweetish salt taste." "Bitter mucous taste.'' 3M THUJA OCCIDENTALS. STOOLS. Diarrhoea4: stools hard3; scanty2. Discharge or mucus or slime from the anus4. URINARY ORGANS. Sensation of fulness in the bladder2. Pains in the urethra10: stitching2; burning6 (during urina- tion2, after3, about neck of bladder3). Slimy discharge from the urethra2. Itching in the urethra*. Urination frequent12: with urgent desire5. Urine copious9, high colored3, turbid2. SEXUAL ORGANS. Male.—Pains in the glans6: stitches2. Itching on the glans2. The glans began to grow moist and secrete mucus2. Burning on the inner surface of the prepuce2; itching4. Pains felt in the testicles4: stitches3. Sexual desire increased4; lessened3. Female.—Menstruation regular but the amount of discharge lessened3. RESPIRATORY ORGANS. Hoarseness2. Sticking or stitches in the lungs3. Cough12: short and dry5; with secretion of mucus6. Oppression of the chest11. Dyspnoea5: with oppression of the chest4. CHEST. Pressing pains located about the sternum4; under it5. Stitches in the sides of the chest9; right4; left4. Pressing pain in chest3; right side2. Oppression of the chest11. HEART AND PULSE. Accelerated pulse2. Palpitation2. THUJA OCCIDENTALS. 315 NECK AND BACK. Pains in the nape of the neck8: drawing or tensive4; tearing2. Stiffness in the nape2. Pains in left side of neck3. Sensation of pain in the lumbar region5: painful tension2. Pains in the sacral region3: drawing2. Chilliness in the back2. Pains in the neck or back worse from motion3. LIMBS. Upper.—Pains in the shoulder5 (bruised3); in upper arm5 (bruised2); in elbows2; in fore-arm4 (burning2, drawing-stick- ing2) ; in hands4 (tearing2); in fingers4; in thumb3. Lower.—Pains in the thigh3; in the knee7 (tensive2, painful stitches in the left knee3); in lower leg4; in ankles5 (tearing2); in feet8 (tensive2, drawing2). Feeling of weakness in the feet2; lameness3. Cold feet5: icy2. Drawing pain in great toe2. SKIN. Wart-shaped excrescences2. Round, red spots on skin as large as lentils2. Painfnl pimples on the skin5: on face2; inflamed3. The skin burns4; itches2. SLEEP. Drowsiness4: drowsy by day and restless at night3. Restlessness at night11. Dreams7: voluptuous2. CHILL AND FEVER. Chill4. Chilliness8: extending over the whole body5; creeping*. Febrile paroxysm4: one stage wanting3.* * " The chill extended over the whole body, merged into a dry and burn- ing heat, and towards morning a sweat broke out over the whole body. The sweat continued until noon and in the evening a chill returned." " Slight shivering which spread over the whole body, followed by a general sudden 316 THUJA OCCIDENTALS. Sweating8: general6; sweat on inner surface of thigh2. Periodicity of symptoms5: febrile symptoms3. AGGRAVATIONS. Pains come on and are felt chiefly while in motion5; during rest7; during both rest and motion2; pains come on during rest and disappear on motion3. THERAPEUTIC APPLICATION. The headache of thuja appears to be felt in any part of the head, but it centres in the frontal region, being especially severe in the frontal eminences and extending over the tem- ples, even to the mastoid region. The usual character of the pain is pressing, or more generally lancinating, as if a sharp needle or similar instrument were thrust quickly into the head. This may be felt in different localities, and the direction of the pain varies. The headache appears to be simply neuralgic and not connected with the condition of the stomach. In headaches of this character it is generally observed that the eyes are affected also. It is, therefore, in accord with this rule that with the thuja patient burning and stinging on the margins of the eyelids is usual, with quivering of the lids and a feeling as if a foreign body were under them. The con- junctiva is injected; burning and tearing pains are felt in the eyeballs, and vision is obscured. This condition of the eye gives hope for aid in the treatment of keratitis and other dis- eases of the external envelopes. In haemorrhoids and anal fissures new and efficient remedies are needed, and thuja may yield good results in this locality, inasmuch as there seems to be a tendency for the drug to affect these parts. Itching is commonly felt at the anus, and also sweat." "Febrile symptoms came on at night but ceased after midnight, and towards morning perspiration broke out." "In the evening chilliness for several hours passing into burning heat on lying down." THUJA OCCIDENTALS. 317 burning, stitching, piercing pains. The rectal vessels appear to be enlarged and mucus is discharged from the anus. Judging from the provings, the diseases most likely to be benefited by the use of thuja are those of the genito-urinary system. The urine is increased in amount and frequently passed, strong urging to do so being felt at times, and it is high- colored and turbid. Itching is felt in the urethra, and pains shoot along it or are felt in certain portions of its course. Burning pains during or alter micturition occur, and the blad- der feels distended. This exhibits a fair picture of urethritis or even the first stage of gonorrhoea, towards which latter disease other sym- toms point. A slimy discharge oozes from the outlet of the urethra, and the glans is sensitive and painful. A condition resembling balanitis is suggested by burning and itching on the inner surface of the prepuce and the secre- tion of mucus under the prepuce covering the glans. There is sufficient evidence to confirm the use of thuja in condylomata, when they occur in combination with gonor- rhoea or otherwise. The excrescences are generally rough, hard and exude moisture. The remedy is applied to many forms of warts, although in each case the tincture may be re- quired locally. Few remedies have been observed to affect the prostate gland, and yet many persons, especially the aged, suffer from diseases located in this section. Thuja offers relief when pain and burning are distinctly felt in the urethra, near the neck of the bladder. This may be connected with frequent and urgent desire to urinate, which act, however, causes burning pain. Consider also the aid which may be gained from thuja in diseases of the respiratory organs. The stitches in the lungs, together with the cough, hoarseness, secretion of mucus, marked oppression of the chest near the sternum, with diffi- culty of breathing, all point in the direction of help in pneu- monia and kindred diseases. In the beginning of what is called a general cold, which may result in rheumatism, pneu- 22 318 THUJA OCCIDENTALS. monia or bronchitis, with pains or soreness in all the muscles of the body, and especially through the chest, with fever and oppression of breathing, thuja may do good service. The muscles throughout the body feel acutely its influence. Rheumatism, especially when located in the muscles of the limbs and back (lumbago) should yield to the use of this drug, especially also when pain is a prominent symptom (myalgia). The pains are burning, tearing and drawing, with occasional sharp stitches and a bruised sensation. The parts may be cold. Towards torticollis the provings plainly point. Drawing, tearing pains in the nape of the neck, with stiffness; the pain increased by motion. Pains are also felt in the side of the neck. Altogether these symptoms give an excellent similimum of stiff neck. Periodicity is a feature of thuja symptoms, and this appears also in the fever. The chill is decided; fever is present and sweating is profuse. The chill, however, may be followed by a sweat instead of fever; the fever by a sweat without a chill; or chilliness by fever alone. Possibly the missing stage may have been present, but being slightly developed was overlooked. Judging from the provings as recorded, however, thuja would seem to be indicated when a decided chill is followed by a free sweat, the febrile stage being feebly present or entirely wanting. DRUQ INDEX. ACIDUM CARBOLICUM : Remarks on Provings, .... I General Sphere of Action, . . i Symtomatology,....... 2 Therapeutic Application, ... 4 Angina Faucium,...... 5 Apoplexy, .... ... 5 Headache,.......... 4 Indigestion, . . ...... 5 Lumbago,.......... 5 Migraine,.......... 4 Pneumonia,......... 5 Ursemic Coma,........ 5 Vesicular Eruption, ... 5 Vomiting of Pregnancy, ... 5 ACIDUM HYDROCYANICUM : Remarks on Provings, .... 6 General Sphere of Action, . . 6 Symptomatology,...... 7 Therapeutic Application, ... 9 Angina Pectoris,.......10 Asthma,...........10 Cardiac Derangements, .... 10 Congestive Headache, .... 10 Cough,...........10 Dyspnoea,....... 10 Epilepsy........... 9 Gastralgia..........10 Headache,.......... 9 Hysteria,..........10 Hypochondriasis, .....10 Vertigo,...........10 ACIDUM OXALICUM : Remarks on Provings, .... 11 General Sphere of Action, . . 11 Symptomatology,......11 Therapeutic Application, ... 13 Affections of Smaller Intes- tines, ...........14 Angina Faucium.......13 Gastritis,..........14 Glossitis,..........13 Headache,..........13 Irritation of Spinal Cord, . . . 14 Pulmonary Hypersemia, ... 14 Stomatitis...........13 Toothache,.........13 ACIDUM PICRICUM: Remarks on Provings, .... 15 General Sphere of Action, . . 16 Symptomatology,......17 Therapeutic Application, ... 20 Brain Fag,..........20 Conjunctivitis,........21 General Debility,......20 Headache,..........21 Indigestion,........21 Insomnia,........ 21 Locomotor Ataxia,......21 Masturbation,........21 Satyriasis,..........21 ACONITUM NAPELLUS : Remarks on Provings, .... 22 General Sphere of Action, . . 23 Symptomatology,......25 Therapeutic Application, ... 30 Angina Faucium,......32 Asthma............32 Catarrh, ..........31 Cerebral Congestion,.....31 Cough, ..........32 Croup,...........32 Diarrhoea,......... 32 Dysentery,.........32 Erysipelas,.........34 Eye, Inflammation of, .... 31 Fever,.........31-33 Fevers, Eruptive,......34 320 DRUG INDEX. Fright or Vexation, Effects Glaucoma,..... Gonorrhoea,..... Haemoptysis, .... Head, Confusion of, . Headache, Congestive, Heart, Hypertrophy of, Heart, Pains in Region of, Heart, Palpitation of, Hoarseness, . . . Lumbago, . Lungs, Congestion of, Measles, . . Nasal Catarrh, Neuralgia, . . Paralysis, Peritonitis, . Pertussis, . . Pleurisy, . . Pneumonia, . Rheumatism, Scarlet Fever, Stiff Neck, . Vertigo, . Vexation, Effects of, of, 3i 3i 32 33 3i 3i 33 33 33 32 33 33 34 3i !-33 3i 32 32 32 33 33 34 33 31 31 ACLBA RACEMOSA Remarks on Provings, ... 35 General Sphere of Action, . . 35 Symptomatology,......36 Therapeutic Application, ... 38 Indigestion,.........39 Influenza,..........39 Myalgia,..........39 Neuralgia,..........38 Pleurodynia,........39 Rheumatism,........39 Skin Eruption,.......39 Torticallis,.........39 Urticaria,..........39 .ESCULUS HIPPOCASTANUM : Remarks on Provings, .... 40 General Sphere of Action, . . 40 Symptomatology, ... 41 Therapeutic Application, ... 42 Catarrh,...........42 Cough,...........42 Haemorrhoids,........42 Influenza,..........42 Pneumonia, .........42 AGARICUS MUSCARIUS: Remarks on Provings, . . ■ ■ 44 General Sphere of Action, . • 44 Symptomatology, ... 44 Therapeutic Application . . ■ 4$ Apoplexy,........■ • 48 Chilblains,........ 49 Chorea,...........4$ Coryza,..........45~46 Delirium Tremens.......48 Dyspepsia,..........4° Headache,..........4§ Rheumatism,........48 Spinal Irritation........48 Splenic Derangement, ... 48 Typhoid Fever, . . ... 49 AILANTHUS GLANDULOSA: Remarks on Provings, .... 50 General Sphere of Action, . . 50 Symptomatolgy,.......50 Therapeutic Application, ... 53 Brain Fag, ......54 Fever, Low, toxaemic forms of, 53 Measles...........53 Scarlatina,..........53 Spinal Congestion,......53 ALOES: Remarks on Provings, . . . 55 General Sphere of Action, . 55 Symptomatology,......56 Therapeutic Application, ... 59 Diarrhoea...........60 Dysentery,.........60 Haemorrhoids,........5g Ovaries, Congestion of, ... . 60 Pelvic Congestions, .... 60 Uterus, Congestion of, . . . 60 AMYL NITRITE : Remarks on Provings, .... 62 General Sphere of Action, . . 62 Symptomatology,......63 Therapeutic Application, ... 65 Ague,............65 Angina Pectoris,.......65 DRUG INDEX. 321 Asthma,..........65 Epilepsy,.........65 Flushes,...........65 Headaches, Congestive.....65 Spasmodic Asthma, . . . . 65 ANTIMONIUM TARTARICUM: Remarks on Provings, .... 66 General Sphere of Action, . . 67 Symptomatology,......68 Therapeutic Application, ... 71 Albuminuria,........72 Asthma............72 Bronchitis,.........71 Eruptions, ........72 Gastric Catarrh,.......72 Pneumonitis.........72 Varicella,..........72 Variola, ..........72 APISMELLIFICA: Remarks on Provings, .... 73 General Sphere of Action, . . 75 Symptomatology.......75 Therapeutic Application, ... 80 Angina Faucium, .....80 Conjunctivitis, .......81 Coryza,..........80 Cutaneous Erysipelas, .... 80 Diarrhoea, .........80 Diphtheria,.........80 Dysuria,..........80 Intermittent Fever......81 Qjdema Glottidis,......81 Pulmonary CEJdema,.....81 Rheumatism,........81 Urticara,..........80 ARGENTUM NITRICUM: Remarks on Provings, .... 82 General Sphere of Action, . . 82 Symptomatology,......83 Therapeutic Application, ... 87 Alimentary Canal, Diseases of, 88 Brain Fag,.........88 Cholera Infantum, .....89 Chorea............82 Conjunctivitis, .......88 Diarrhoea, .........88 Epilepsy,..........87 Eye, Diseases of,......88 Gonorrhoea,.........89 Hydrocephaloid, ......89 Neuralgia, .........88 Nervous Prostration,.....87 Nervous System, Diseases of, . 87 Urinary Tract, Diseases of, . . 89 ARNICA MONTANA: Remarks on Provings, .... 90 General Sphere of Action, . . 90 Symptomatology,......91 Therapeutic Application, ... 94 Anaemia,.........94 Bruises,...........94 Concussion,.........94 Contusions, ........94 Diarrhoea,...... . . . 95 Dermatitis, ........95 Ecchymoses, ........ 94-95 Effusions, Bloody, ...... 94 Epistaxis,..........94 Erysipelatous Inflammations, 95 Gastric Catarrh,.......95 Gastritis...........95 Gastrodynia,....... 95 Headache..........94 Hemorrhage,.......94 Heart, Injuries to,......94 Intestinal Inflammation, . . 95 Mechanical Injuries,.....94 Myelitis,..........95 Rheumatism,........95 Shock.......... .94 Spinal Troubles,.......95 Sprains,...........94 Tabes Dorsalis,.......95 Traumatic Erysipelas, .... 95 Vertigo,...........94 ARSENICUM ALBUM: Remarks on Provings, ... 96 General Sphere of Action, . . 97 Symptomatology, .....100 Therapeutic Application, . . . 105 Adynamia,.........106 Albuminuria,........107 Anaemia,..........108 322 DRUG Angina Pectoris, ......108 Bright's Disease,.......108 Chlorosis,..........108 Cholera,..........107 Conjunctivitis, .......106 Coryza, • ........107 Diarrhoea,..........io7 Fever,...........Jo8 Heart, Fatty,........108 Influenza,..........107 Intermittent Fever......108 Malignity,.........106 Nephritis,..........107 Oedema...........106 Pains,............106 Remittent Fever,......108 Restlessness and Anxiety, . . 106 Scarlatina,.........109 Scarlatinal Nephritis, .... 109 Skin, Diseases of,.....108 Special Application,.....106 Thirst, .........106 Typhoid Fever,.......109 Variola,...........109 Yellow Fever.........109 BELLADONNA: Remarks on Provings, . . . .110 General Sphere of Action, . .110 Symptomatology, in Therapeutic Application, . . .115 Acute Mania, . . .....116 Albuminuria,........118 Angina Faucium,......118 Cerebral Congestion,.....117 Choroiditis,.........117 Colic,.......... 118 Conjunctivitis,........117 Convulsions,.........116 Dentition,..........118 Eclampsia,.........116 Erysipelas,.........119 Exanthemata,........119 Fevers,...........119 Headache,..........116 Hemicrania,.........117 Iritis.............117 Laryngismus Stridulus, . . .116 INDEX. Locomotor Ataxia,......116 Mania-a-potu,........116 Motor Affections,.....116 Neuralgia,...... iJ7 Peritonitis,.........Il8 Pertussis,..........IJ6 Puerperal Convulsions, . . .116 Respiratory Organs, Affections, 119 Retinal Hyperaemia,.....117 Scarlatina,.........119 Spinal Paralysis, . . 116 Strumous Ophthalmia, . . . .117 Sunstroke,.......117 Teething of Infants,.....118 Thirst,...........118 Toothache,.........117 Uterine Inflammation, . . . .119 Vertigo,.......... 116 BROMINE: Remarks on Provings, ... 121 General Sphere of Action, . .121 Symptomatology,......122 Therapeutic Application, . . . 124 Bronchitis,.........124 Cough,..........124 Croup,...........124 Diarrhoea...........124 Diphtheria,.........124 Gastric Derangement, . . . .124 Headache,.........124 Indigestion,.........124 Influenza,..........124 Pneumonia,.........124 Vertigo,...........124 BRYONIA ALBA: Remarks on Provings, . . . .125 General Sphere of Action, . .125 Symptomatology,......126 Therapeutic Application, . . . 132 Acute Angina Faucium, . . . 132 Bronchitis, . . .....132 Cardiac Inflammation, .... 134 Circulatory System, Affections, 134 Colic,............133 Constipation,........134 Cough,.........132-133 Croup,........• . . . 132 DRUG INDEX. 323 Diabetes Insipidus,.....134 Diarrhoea,..........134 Digestive Organs, Derange- ment of,..........133 Dyspepsia,.........133 Epistaxis,........132-134 Headache,.........132 Hoarseness,.........132 Irritable Heart,.......134 Laryngitis,..... ... 132 Meningeal Inflammation, . . 132 Nasal Catarrh,........132 Nephritis, ... ......134 Pleuritis, .........133 Pneumonitis.........133 Rheumatism,........134 Skin Affections,.......134 Typhoid Fever,.......134 Urinary Organs, Affections of, 134 CAMPHORA: Remarks on Provings, . . General Sphere of Action, Symptomatology, .... Therapeutic Application, . Asiatic Cholera,..... Bladder, Inflammation of, Choleraic Affections, . . . Head, Congestion of, . . Insolation,...... Urethra, Inflammation of, Vertigo, ........ CANNABIS INDICA: Remarks on Provings, . General Sphere of Action Symptomatology, . . Therapeutic Application, Alcoholic Intoxication, Catalepsy, ... Catarrhalis Senilis, . Chronic Alcoholismus, Delirium, ..... Delirium of Fevers, Delirium Tremens, Duality, Sense of, . Ecstasy,..... Hallucinations, . . Headache, .... 135 135 137 137 138 138 138 138 138 138 138 139 141 142 H7 147 149 149 H7 148 148 147 148 148 148 149 Insanity,..........148 Mania,...........148 Morbus Brightii.......149 Neuralgia,.........149 Paralysis...........149 Paralysis of the Insane, . . . 149 Typhoid Fever........148 Vertigo...........149 CANTHARIS VESICATORIA: Remarks on Provings, . . . .150 General Sphere of Action, . .150 Symptomatology,......151 Therapeutic Application, . . . 154 Angina Faucium,......154 Bright's Disease,......155 Conjunctiva, Affections of, . . 154 Cystitis, ..........155 Diphtheria,.........154 Dysentery,.........154 Erysipelas of Face,.....154 Gonorrhoea,.........155 Hydrophobia,........154 Mania,...........154 Nephritis,..........155 Peritonitis,........154 Pleurisy,..........154 Pruritus Vulvae,.......155 Renal Calculi,........155 Spermatorrhoea,.......155 CARBONEUM SULPHURATUM: Remarks on Provings, .... 156 General Sphere of Action, . .157 Symptomatology,......158 Therapeutic Application, . . . 161 Bronchitis,.........162 Diarrhoea, .........162 Headache..........161 Hordeolum,.........162 Indigestion,.........161 Laryngitis, . . .....162 Lumbago,..........162 Myalgia,..........162 Respiratory Mucous Membrane, Catarrh of,.........162 Tinnitus Aurium, .... 158-161 Urticaria,..........162 324 DRUG INDEX. CARBO VEGETABILIS: Remarks on Provings, . . . .163 General Sphere of Action, .164 Symptomatology,......164 Therapeutic Application. . . .167 Acute Catarrh of Bronchi, . .167 Acute Catarrh of Pharynx, . .167 Acute Catarrh of Larynx, . .167 Acute Catarrh of Trachea, . .167 Acute " Cold,".......167 Constipation, .......167 Gastric Derangements, . . . .167 General Debility,......167 Headache, ...... .167-168 Hoarseness,.........167 Mental Depression,..... 167 Indigestion,.........167 Restless Sleep,......168 CHAMOMILLA: Remarks on Provings, .... 169 General Sphere of Action, . .169 Symptomatology,......170 Therapeutic Application, . . . 172 "Bilious Fever,"......173 Colic,...........173 Dentition,..........173 Diarrhoea, ........ 173 Headache,........172 Indigestion,........173 Jaundice,..........173 Teething of Children, . . . .173 Tetanus,..........173 Toothache,.........172 CHELIDONIUM MAJUS: Remarks on Provings, . . . .174 General Sphere of Action, . .174 Symptomatology, ... 174 Therapeutic Application, . . .178 Acute Gastric Catarrh.....178 Acute Hepatitis,.......178 Bronchitis,.........178 Catarrhal Pneumonia, . . . .179 Cough,......... .178 Duodenitis,.........178 Headache, ........178 Icterus, ... .......178 Influenza,..........178 Migraine...........178 Nephritis,..........178 Pertussis,..........178 Pneumonia,.........178 Rheumatism,........178 Toothache,.........178 Vertigo,...........178 CHINA: Remarks on Provings, . . . .180 General Sphere of Action, . .180 Symptomatology, .....181 Therapeutic Application, . . 182 Bulimia...........182 Colic.............182 Diarrhoea, .........182 Digestive Derangements, . . .182 Headache,.........182 Intermittent Fever,.....183 Palpitation of Heart......182 CHININUM SULPHURICUM: Remarks on Provings, . . . .184 General Sphere of Action, • 185 Symptomatology,......186 Therapeutic Application, . . .189 Amaurosis,.........190 Anaemia,..........189 Blindness, ...... . . 190 Constipation,........190 Deafness...........190 Delirium Tremens,.....190 Diarrhoea,........191 Digestive Disturbances, . . .190 Febrile Affections, . . . . 191 General Debility,......189 Gout,............191 Headache .........190 Hepatic Derangement, .... 191 Intermittent Fever......191 Leucaemia,.......190-191 Liver Diseases........191 Paralysis of Special Senses, .190 Rheumatism,....... . 191 Spanaemia..........190 Splenic Derangement.....191 Tinnitus Aurium,......190 Vertigo, ..........190 DRUG INDEX. 325 CICUTA VIROSA: Remarks on Provings, . . . .192 General Sphere of Action, . .192 Symptomatology, ..... 192 Therapeutic Application, . .194 Asthma,..........194 Cerebro-Spinal Meningitis, . .194 Eczema, ..........195 Epilepsy,..........194 Headache,.........194 Hiccough, .........194 Tetanus,.........194 CLEMATIS ERECTA: Remarks on Provings, .... 196 General Sphere of Action, . .196 Symptomatology,......196 Therapeutic Application, . . . 199 Cutaneous Irritation.....199 Eczema of Scalp,......199 Eyelids, Inflammation of, . .199 Gonorrhoea..........200 Headache..........199 Incipient Stricture,.....200 Inflammation of Inguinal Glands,..........200 Iritis,............199 Orchitis,..........200 Rheumatism,........200 Toothache,.........200 COCA, ERYTHROXYLON : Remarks on Provings, .... 201 General Sphere of Action, . 201 Symptomatology, ... 202 Therapeutic Application, . . . 204 Cardiac Disturbance......205 Constipation.........205 Digestive Disturbance, .... 205 Dyspnoea...........205 Headache,..........205 Insomnia, ... .... 205 Nervous Excitement,.....204 Nervous System, Derangement of,...........204 Vertigo,..........205 COCCUS CACTI: Remarks on Provings, .... 206 General Sphere of Action, . . 206 Symptomatology,......207 Therapeutic Application, . . . 212 Air Passages, Acute Diseases of, 213 Cough, .......... 213 Headache,.........212 Hoarseness,.........213 Pertussis,...... . . 213 Respiratory Tract, Affections of,...........213 Rheumatism, Muscular, . . .212 Sore Throat,...... . 213 Urinary Organs, Affections of, 213 COLOCYNTHIS: Remarks on Provings, . . . .214 General Sphere of Action, . .216 Symptomatology, ... 216 Therapeutic Application, . . .220 Colic,............220 Diarrhoea,..........220 Dysentery,.........220 Headache,.........221 Indigestion, ... .... 220 Nervous Colic,.......220 Neuralgia, . . . .221 Neuroses,...... • 221 Ovarian Neuralgia.......221 Peritonitis, . . . . ■ 220 Rheumatic or Gouty Headache, 221 Sciatica,...........221 Urinary Affections,......221 CROTALUS: Remarks on Provings, .... 222 General Sphere of Action, . . 223 Symptomatology,......224 Therapeutic Application, . . 227 Adynamia, .........227 Black Vomit,........228 Cerebro-Spinal Meningitis, . . 227 Delirium,..........227 Diphtheria,.........228 Ecchymoses,.........227 Epistaxis,......... 228 Gangrene,..........227 Haemorrhages,........227 Purpura Hsemorrhagica, . 229 Remittent Fever,......228 Scarlatina Maligna..... 228 326 DRUG INDEX Typhoid Fever,.......228 Typhus Fever,........229 Variola,...........229 Yellow Fever,........228 CROTON TIGLIUM: Remarks on Provings, .... 230 General Sphere of Action, . . 230 Symptomatology,......231 Therapeutic Application, . . . 234 Cutaneous Diseases,.....235 Diarrhoea,..........235 Eczema,...........235 Febrile Conditions,......235 General Indications, .... 235 Indigestion,.........235 Tenesmus,.......... 235 CUPRUM ACETICUM : Remarks on Provings, .... 237 General Sphere of Action, . . 237 Symptomatology,......238 Therapeutic Application, . . . 240 Angina Pectoris,.......242 Asthma,...........242 Cholera,...........242 Chorea,...........242 Convulsions,.........241 Cramps,...........241 Epilepsy,..........241 Laryngismus Stridulus, . . . .241 Mania,...........241 Meningitis,.........241 Nervous Asthma,......242 Stomach and Bowels, Affec- tions of,..........242 Tetanus,...........241 Trismus,...........141 Whooping Cough,......242 CYCLAMEN EUROPIUM : Remarks on Provings, .... 243 General Sphere of Action, . . 243 Symptomatology,......243 Therapeutic Application, . . . 245 Coryza,...........246 Diarrhoea,..........246 Digestive Derangements, . . . 246 Headache,..........246 Melancholy,.........246 Menstrual Derangements, . . 246 Ophthalmic Disturbance, . . . 246 Tinnitus Aurium,......246 GELSEMIUM SEMPERVIRENS: Remarks on Provings, .... 247 General Sphere of Action, . . 248 Symptomatology,......249 Therapeutic Application, . . . 253 Acute Alcoholismus,.....255 Apoplexy,..........254 Blindness,..........255 Cerebro-Spinal Meningitis, . . 254 Diarrhoea,..........256 Diplopia,.........255 Emotional Derangements, . . 253 Fright, Effects of,......253 Gastralgia,.........355 Grief, Effects of,.......253 Headache,........254 Intermittent Fever,.....256 Measles,...........256 Myalgia,..........256 Neuralgia, . . .......255 Neurotic Disturbances, .... 253 Paralysis,.........254 pt°sis,...........255 Rheumatism, . . .....256 Strabismus,.........255 Sunstroke,.........254 Typhoid Fever,......256 Vertigo,...........254 GLONOINUM : Remarks on Provings, .... 257 General Sphere of Action, . . 257 Symptomatology,......258 Therapeutic Application, . . .261 Agina Pectoris,.......262 Apoplexy,..........262 Cerebral Congestion......262 Convulsive Seizures,.....262 Headache,..........261 Menstrual Derangements, . . 262 Sunstroke, ........262 HAMAMELIS VIRGINICA: Remarks on Provings, . . .263 DRUG INDEX. 327 General Sphere of Action, . . 263 Symptomatology,......264 Therapeutic Application, . 265 Catarrh,....... 266 Haemorrhage,........265 Haemorrhoids,........266 Orchitis,...........266 Urinary Difficulties,.....266 Yaricosis,..........266 HYDRASTIS CANADENSIS: Remarks on Provings, .... 267 General Sphere of Action, . 267 Symptomatology,......267 Therapeutic Application, . . . 269 Bile Ducts, Catarrh of, ... . 269 Chronic Catarrh,......269 Duodenal Catarrh,......270 Erysipelas, Acute,......270 Headache,......... 269 Mucous Membranes, Catarrh of,............269 KALI BICHROMICUM: Remarks on Provings, . . . 271 General Sphere of Action, . . 272 Symptomatology, . . . . 273 Therapeutic Application, . . . 278 Angina Faucium,.....280 Bronchitis,.........280 Catarrh, ..........280 Coryza,...........280 Diphtheria,.........280 Epistaxis...........280 Headache, ........279 Larynx, Affections of, ... 280 Membranous Croup......281 Ocular Troubles........280 Ozaena,..........280 Pharynx, Affections of, ... 280 Rheumatism,.......278 Syphilis,.........279 Trachea, Affections of, . . . .280 Urinary Tract, Diseases of, . . 281 Variola, . . ...... 279 KALI CHLORICUM: Remarks on Provings, .... 282 General Sphere of Action, . .282 Symptomatology,......283 Therapeutic Application, ... 285 Asthma,.........286 Catarrhal Irritation......285 Coryza,...........285 Cutaneous Eruptions, .... 286 Diarrhoea,..........286 Dysentery,.........286 Epistaxis,..........285 Gastritis,......... 286 Headache,.........285 Heart, Disturbance of, ... . 285 Nephritis,..........286 Scarlatina,.........286 Urticaria,..........286 LILIUM TIGRINUM: Remarks on Provings, . General Sphere of Action, Symptomatology, . . . Therapeutic Application, Anteversion of Uterus, . Heart, Disturbance of, . Leucorrhcea,..... Mental Disturbance, . . Ovaries, Affections of, . Uterine Mal-position, . OPIUM: Remarks on Provings, . General Sphere of Action Symptomatology, . . . Therapeutic Application, Congestive Chills, Conjunctivitis, . . . Constipation,..... Delirium,....... Diarrhoea..... Digestive Disturbances, Headache,...... Malarial Fevers, .... Mental Derangements, . Paralysis,....... Pulmonary Congestion, Typhoid Fever, .... SANTONINUM: Remarks on Provings, . . General Sphere of Action, 288 289 290 294 294 294 294 294 294 294 296 297 298 303 305 3°5 304 303 304 303 305 304 303 303 303 304 306 306 328 DRUG INDEX. Symptomatology, .... • 307 317 Therapeutic Application, . ■ .308 Bronchitis,........ • 317 • 309 Condylomata,..... 317 • 309 Conjunctiva, Injection of, . 3i6 Enuresis,....... 309 317 • 309 • 317 Helminthiasis,..... 309 ■ 316 Intestinal Irritation, . . . • 309 3i6 Ocular Troubles, ... • 309 317 Worms,......... • 309 3i6 HUJA OCCIDENTALIS: Periodicity of Symptoms, . 3i8 317 Remarks on Provings, . . • 310 Prostate Gland, Disturbance of, ^17 General Sphere of Action, • 3H Rheumatism,....... . 3T8 Symptomatology, .... • 3" 3t8 Therapeutic Application, . .316 Warts........... 317 317 Anal Fissures,...... • 3J6 Urethritis......... THERAPEUTIC INDEX. ACUTE ALCOHOLISMUS: Cann. Ind.,.........147 Gels.,............255 ACUTE CATARRH OF BRON- CHI: (See Bronchitis.) ACUTE CATARRH OF LAR- YNX: (See Laryngitis.) ACUTE CATARRH OF PHAR- YNX: (See Angina Faucium.) ACUTE CATARRH OF TRA- CHEA: (See Trachea, Acute Catarrh of.) ACUTE "COLD:" Carbo veg.,.........167 ACUTE GASTRIC CATARRH: (See Gastritis.) ACUTE ERYSIPELAS: (See Erysipelas.) ACUTE HEPATITIS: (See Hepatitis, Acute.) ACUTE MANIA: (See Mania.) ADYNAMIA: Acid, carbol.,........ 2 Acid, pic, ........20 Ars. alb.,..........106 Chin, sul...........189 Crotal.,...........227 AFFECTIONS OF CONJUNC- TIVA: (See Conjunctiva, Affections of.) AFFECTIONS, FEBRILE: (See Febrile Conditions.) AFFECTIONS OF LARYNX: (See Larynx, Affections of.) AFFECTIONS OF OVARIES: (See Ovaries, Affections of.) AFFECTIONS OF RESPIRA- TORY TRACT: (See Respiratory Tract Affec- tions. ) AFFECTIONS OF TRACHEA: (See Trachea, Affections of.) AFFECTIONS OF URINARY ORGANS: (See Urinary Affections, and Urinary Organs,Diseases of.) AGUE: Amyl nitr.,.........65 Apis,............81 Ars. alb...........108 Chin., ..........183 Chin, sul.,.........191 Gels.,............225 ALBUMINURIA: Ant. tart.,..........72 Ars. alb.,..........107 Bell.,...........118 ALCOHOLIC INTOXICATION: Cann. Ind.,.........147 Gels.,............255 ALCOHOLISMUS, ACUTE: Cann. Ind.,.........147 Gels..............255 ALCOHOLISMUS, CHRONIC: Cann. Ind.,.........147 33° THERAPEUTIC INDEX. ALIMENTARY CANAL, DIS- EASES OF: Acid, carbol.,........ 5 Acid, oxal.,.........14 Acid, pic,..........21 Aeon.............32 Act. rac,..........39 Agar, muse,........48 Aloes, ...........60 Ant. tart.,.........72 Apis,............80 Arg. nit.,.........88-89 Arn.............95 Ars. alb............107 Brom.,...........124 Bry. alb.,....... I33-T34 Camph.,..........138 Canth.,...........154 Carb. sulph.,......161-162 Carbo veg.,.........167 Cham.,...........173 Chelid.,...........178 Chin.,...........182 Chin, sul.,.......190-191 Coca,............205 Coloc,...........220 Crot. tig.,..........235 Cupr. acet.,........ 242 Cyclam.,......... 246 Gels.,........... 255 Kali bi.,..........276 Kali chlor.,.........286 Opi...........303-304 Sant., ...........309 AMAUROSIS: Chin, sul.,.........190 ANAEMIA: Arn.,............94 Ars. alb.,..........108 Chin, sul.,.........189 ANAL FISSURE: Thuja............316 ANGINA FAUCIUM: Acid, carbol.,........ 5 Acid, oxal.,.........13 Aeon.,...........32 Apis,............80 Bell.,...........118 Bry. alb.,..........132 Canth.,...........154 Kali bi.,..........280 ANGINA PECTORIS: Ac. hydroc., .... . . 10 Amyl nit.,.........65 Ars. alb.,..........108 Cupr. acet.,.........242 Glon.,...........262 ANTEVERSION OF UTERUS: (See Uterus, Anteversion of.) APOPLEXY: Acid, carbol.,........ 5 Aeon.,...........31 Gels.,............254 Glon.............262 ASIATIC CHOLERA: Ars. alb.,..........107 Camph.,..........138 Cupr. acet.,.........242 ASTHMA: Acid, hydroc, .......10 Aeon.,...........32 Amyl nit.,.........65 Ant. tart............72 Cic. vir............194 Cupr. acet.,.........242 Kali chlor..........286 ASTHMA, NERVOUS: Cupr. acet,.........242 ASTHMA, SPASMODIC: Amyl nit.,.........65 BALANITIS: Thuja,...........317 BILE DUCTS, CATARRH OF: Hydras.,..........269 "BILIOUS FEVER:" Cham.,..........173 BLACK VOMIT: Crotal.............228 THERAPEUTIC INDEX. 331 BLINDNESS: Chin, sul.,.........190 Gels.,............255 BRAIN FAG: Acid, pic, ........20 Ailanth.,..........54 Arg. nit.,.........88 BRIGHT'S DISEASE: Ars. alb.,..........108 Cann. Ind.,..... . . 149 Canth.,...........155 BRONCHITIS: Ant. tart.,..........71 Brom.,...........124 Bry. alb.,..... . . 132 Carb. sul., .........162 Carbo veg.,.........167 Chelid.,...........178 Kali bi.,..........280 Thuja,...........317 BRUISES: Arn.,...........94 CALCULI, RENAL: Canth.,..... CARDIAC DERANGEMENTS Acid, hydroc Aeon., . Amyl nit., Ars. alb., Bry. alb., Coca, . . Lil. tig., Glon., . 155 33 65 108 134 205 294 262 CARDIAC INFLAMMATION: Bry. alb.,..........134 CATALEPSY: Cann. Ind., . . ......149 CATARRH: Acid, hydroc,........10 Aeon.,...........31 yEscul.,..........42 Ant. Tart...........72 Apis.............80 Arg. nit.,..........86 Brom.,...........124 Bry. alb.,..........132 Carbo veg.,........167 Chelid............178 Cocc. cact.,.........213 Gels.,............251 Hamam.,..........266 Hydras.,.........269 Kalibi............280 CATARRH, CHRONIC: Hydras.,..........269 Kali bi.,...........280 CATARRH, GASTRIC: (See Gastritis.) CATARRH, NASAL: Aeon.,...........31 iEscul.,..........42 Bry. alb.,..........132 Hydrast.,..........269 Kalibi.,........280 CATARRHAL PNEUMONIA: Chelid.,...........179 CATARRH OF BILE DUCTS: (See Bile Ducts, Catarrh of.) CATARRH OF RESPIRATORY MUCOUS MEMBRANE: Aeon............31-32 yEscul............42 Ant. tart.,.........72 Apis,............80 Arg. nit.,..........86 Brom.,..........124 Bry. alb.,..........132 Carb. sul.,..........162 Carbo veg.,.........167 Chelid............178 Cocc. cact.,.........213 Gels.,............251 Hamam............266 Hydras.,..........269 Kalibi........... 280 Kali chlor.......... 285 Thuja........314-317-318 CEREBRAL CONGESTION: Aeon.,..........31 332 THERAPEUTIC INDEX. Amyl nit.,..........65 Bell.,............H7 Bry. alb.,..........T32 Gels.,.......... 254 Glon.,..........262 CEREBRO-SPINAL MENIN- GITIS: Cic. vir............194 Crotal.............227 Gels.,............254 CHICKEN POX: (See Varicella.) CHILBLAINS: Agar, muse,........49 CHILLS, CONGESTIVE: Opi., ...........305 CHLOROSIS: Ars. alb., .... .....108 Chin, sul., .......189-t90 CHOLERA: Ars. alb.,..........107 Camph.,..........138 Cupr. acet.,.........242 CHOLERAIC AFFECTIONS: Camph.,..........138 CHOLERA INFANTUM: Arg. nit.,......... . 89 Ars. alb.,..........107 Cupr. acet., . . ......242 CHOREA: Agar, muse,........48 Arg. nit.,..........82 Cupr. acet.,.........242 Sant.,............3°9 CHOROIDITIS: Bell..............117 CHRONIC ALCOHOLISMUS: Cann. Ind.,.........147 CHRONIC CATARRH: Hydras............269 Kali bi.,.........280 COLIC: Bry. alb.,..........133 Cham.,...........173 Chin.,............182 Coloc,...........220 Cupr. acet., ... .....242 Opi.,............304 COLIC, NERVOUS: Coloc,...........220 COMA, UREMIC: Acid, carbol.,........ 5 CONDITIONS, FEBRILE: (See Febrile Conditions.) CONDYLOMATA: Thuja,...........3J7 CONGESTION, CEREBRAL: (See Cerebral Congestion.) CONGESTION OF LUNGS: (See Pulmonary Congestion.) CONGESTION OF OVARIES: (See Ovarian Congestion.) CONGESTION, PELVIC: (See Pelvic Congestion.) CONGESTIVE CHILLS: Opi.,............305 CONGESTION, PULMONARY: (See Pulmonary Congestion.) CONGESTION, SPINAL: (See Spinal Congestion.) CONGESTIVE HEADACHE: (See Headache, Congestive.) CONJUNCTIVA, AFFECTIONS OF: Acid, pic,.........21 Aeon.............31 Arg. nit............88 Ars. alb............106 Bell.,............117 Canth.,...........154 Opi-.............305 Thuja,...........316 CONJUNCTIVITIS: Acid, pic,.........21 Apis,............81 THERAPEUTIC INDEX. 333 Arg. nit.,..........88 Ars. alb...........106 Bell.,............117 Opi-.............305 CONSTIPATION: Act. rac,..........37 Ars. alb.,..........103 Bry. alb.,..........134 Camph.,..........137 Carbo veg..........167 Chin, sul...........190 Clemat., ..........198 Coca.,...........205 Cocc. cact.,.........210 Crotal.,...........226 Cupr. acet.,.........239 Hamam.,.......... 264 Kalibi., ..........276 Opi.,............304 CONTUSIONS: Arn.,............94 CONVULSIONS: Arg. nit.,........83-87 Bell.,..........116 Cic vir.,........192-194 Cupr. acet.,.......238-241 Glon.,........ 258-262 Sant.,..........307-309 CONVULSIONS, PUERPERAL: Bell.,............116 CORYZA: ^Bscul............41-42 Ars. alb..........101-107 Cyclam..........244-246 Kali bi., ..........280 Kali chlor.,.......283-285 COUGH: Acid, carbol.,........ 3 Acid, hydroc,........10 Acid, oxal.,.........13 Aeon.,...........32 ^Escul.,...........42 Agar, muse,........47 Ailanth............ 52 Aloes, ...........58 23 Ant. tart...........71-72 Apis,............78 Arg. nit.,..........86 Arn.,............92 Ars. alb.,..........103 Brom.,...........124 Bry. alb..........132-133 Canth.,...........i53 Carb. sul., .......160-162 Carbo veg.,.......166-167 Chelid.,...........178 Chin, sul.,.........188 Clemat.,..........198 Cocc. cact.,.........213 Crotal.,...........226 Cyclam.,......... 245 Kali bi.,.......276-280 Kali chlor.,.........284 Lil. tig............293 °pi-...........301-303 Thuja,...........317 COUGH, WHOOPING: (See Pertussis.) CRAMPS: Coloc,..........218 Cupr. acet.,.........241 CROUP: Aeon.,..........32 Brom.,...........124 Kalibi.,..........281 CROUP, MEMBRANOUS: Kali bi.,..........281 CUTANEOUS DISEASES: Acid, carbol.,........ 5 Aeon.,...........34 Act. rac,..........39 Ailanth.,..........53 Ant. tart..........72 Apis,............80 Arn.............95 Ars. alb., . .......108 Bell.,............119 Canth.,.......... 154 Crotal.,......... 226-228 Crot. tig.,..........235 334 THERAPEUTIC HINTS. Gels.,............252 Hydras.,.........270 Kali bi.,..........279 Kali chlor.,.........286 CUTANEOUS ERUPTIONS: Acid, carbol.,........ 5 Act. rac.,....'......39 Ailanth.,....... • • 53 Ant. tart.,..........72 Apis,...........80 Bell.,......... 119 Crotal.,...........226 Crot. tig.,..........235 Gels.,............252 Kali chlor.,.........228 CUTANEOUS ERYSIPELAS: Aeon.,..........34 Apis.............80 Arn.,..... .....95 Bell.,............119 Canth.,...........154 Hydras............270 CUTANEOUS IRRITATION: Aeon.,......... 29-30 Act. rac,.........38-39 Apis,...........79-80 Arn.,...........93-95 Bell.,..........115-119 Canth., ....... I53~I54 Clemat.,..........199 Crot. tig.,........234-235 Hydras.,........269-270 Kali chlor., .... 284-285-286 CYSTITIS: Camph.,..........138 Canth.,...........155 DEAFNESS: Agar, muse,........45 Chin, sul.,.........190 Crot. tig.,..........232 DEBILITY, GENERAL: Acid, carbol.,........ 2 Acid. pic............20 Arg. nit.,.........83-87 Ars. alb.,........100-106 Carbo veg.,.........167 Chin, sul.,........189 DELIRIUM: Agar, muse,........48 Bell.,............Il6 Cann. Ind.,.........T48 Cie vir.,.........*93 Crotal.,..........227 Opi.,...... .-• 303 DELIRIUM TREMENS: Agar, muse,........48 Bell.,...........n6 Cann. Ind.,.........147 Chin, sul.,.........19° DENTITION: Bell.,............n8 Cham.,...........173 DERANGEMENTS, CARDIAC: (See Cardiac Derangements.) DERANGEMENTS, EMO- TIONAL: (See Emotional Derange- ments. ) DERANGEMENTS, GASTRIC: (See Gastric Derangements.) DERANGEMENTS, HEPATIC: (See Hepatic Derangements.) DERANGEMENTS, MEN- STRUAL: (See Menstrual Derange- ments. ) DERANGEMENTS OF NERV- OUS SYSTEM: (See Nervous System,Derange- ments of.) DERANGEMENT, SPLENIC: (See Splenic Derangement.) DERMATITIS: Arn., ...........95 DIABETES INSIPIDUS: Bry. alb.,..........134 DIARRHCEA: Aeon.,...........32 THERAPEUTIC INDEX. 335 Aloes, ...........60 Apis,............80 Arg. nit.,..........88 Arn.,............95 Ars. alb., .........107 Brom.,.......... 124 Bry. alb.,..........134 Carb. sul., .........162 Cham.,...........173 Chin.,...........182 Chin, sul.,.........191 Coloc,...........220 Crotal.,...........226 Crot. tig.,..........235 Cupr. acet.,.........240 Cyclam.,..........246 Gels.,............256 Glon.,...........260 Kalibi.,...........276 Kali chlor.,.........286 Opi., . . •.........304 DIFFICULTIES, URINARY: (See Urinary Difficulties.) DIGESTIVE ORGANS, DE- RANGEMENTS OF: Arg. nit.,..........88 Brom.,..........124 Bry. alb.,..........133 Chin.,...........182 Chin, sul.,.........190 Coca,............205 Cyclam., . . . . •.....246 DIPHTHERIA: Apis,............80 Brom.,...........124 Canth.,...........154 Crotal.,...........228 Kali bi.,..........280 DISEASES OF ALIMENTARY CANAL: (See Alimentary Canal, Dis- eases of.) DISEASES OF NERVOUS SYSTEM: (See Nervous System,Derange- ments of.) DISEASES OF SKIN: (See Cutaneous Diseases.) DISEASES OF URINARY TRACT: (See Urinary Tract, Diseases of.) DISTURBANCE OF HEART: (See Heart, Disturbance of.) DISTURBANCE, MENTAL: (See Mental Disturbance.) DISTURBANCE, OPHTHAL- MIC: (See Ocular Troubles.) DISTURBANCE OF PROS- TATE GLAND: Thuja,...........317 DYSENTERY: Aeon.,............32 Aloes,............60 Canth.,...........154 Coloc,...........220 Kali chlor.,.........286 DYSPEPSIA: (See Indigestion.) DYSPNCEA: Acid, hydroc,........10 Aeon.,............28 Amyl nit.,..........64 Ant. tart.,.........70-72 Apis,............78 Ars. alb.,..........103 Bry alb.,..........129 Cann. Ind.,.........146 Canth.,...........153 Carb. sul.,........160-162 Cic vir.,..........193 Coca,...........205 Cocc. cact,.........210 Crotal.,........ . 226 Gels.,............251 Kali bi.,...........276 Lil. tig.......... . 294 Opi., .......... 301-303 Thuja,............3H 336 THERAPEUTIC INDEX. DYSURIA: Apis.............80 Ars. alb............103 Cann. Ind.,.........146 Canth.,.........152-155 Opi.,............3QI DUALITY, SENSE OF: Cann. Ind.,.........148 DUODENITIS: Chelid.,...........178 Hydras.,..........270 ECCHYMOSES: Arn.............94-95 Crotal.,...........227 ECLAMPSIA: (See Convulsions.) ECSTASY: Cann. Ind.,.........148 ECZEMA: Cic. vir.,..........195 Clemat.,...........199 Crot. tig.,..........235 ECZEMA OF SCALP: Clemat., . .........199 EFFECTS OF FRIGHT: (See Fright, Effects of.) EFFECTS OF GRIEF: (See Grief, Effects of.) EFFECTS OF VEXATION: (See Vexation, Effects of.) EMOTIONAL DERANGE- MENTS: Gels........... . . .253 ENURESIS: Sant,............309 EPILEPSY: Acid, hydroc,........ 9 Amyl. nit,.........65 Arg. nit,..........87 Cic. vir............194 Cupr. acet.,...... .241 Sant.,............309 EPISTAXIS: Arn.,............94 Bry. alb.,........132-134 Crotal.,...........228 Kali chlor.,.........285 ERUPTIONS, CUTANEOUS: (See Cutaneous Eruptions.) ERUPTIONS, VESICULAR: Acid, carbol.,........ 5 Arn.,...........93-95 Clemat............x99 Crot. tig.,........234-235 ERUPTIVE FEVERS: (See Exanthemata.) ERYSIPELAS: Aeon.,............34 Apis,............80 Arm,............95 Bell.,............"9 Canth.,...........J54 Hydras.,..........270 ERYSIPELAS, FACIAL: Arn.,............95 Bell.,............"9 Canth.,...........154 ERYSIPELAS, TRAUMATIC: Arn.,............95 EXANTHEMATA: Aeon.,..........34 Ant. tart.,..........72 Ars. alb.,..........109 Ailanth.,........• • 53 Bell., ..........119 Crotal.,...........228 Gels., ...........256 Kali chlor.,.........286 EYE, INFLAMMATION OF: (See Conjunctivitis.) FACIAL ERYSIPELAS: (See Erysipelas, Facial.) FEBRILE AFFECTIONS: (See Febrile Conditions.) THERAPEUTIC INDEX. 337 FEBRILE CONDITIONS: Aeon.,...........31-33 Ailanth.,..... • • • • 53 Ant. tart.,..........72 Apis,...........80-81 Ars. alb.,....... 108-109 Bell.,............119 Bry. alb.,..........134 Cann. Ind...........148 Chin.,............183 Chin, sul.,......... 191 Crotal.,.........228-229 Gels.,..........254-256 Kali chlor.,.........286 FEVERS: Aeon.,...........31-33 Ailanth............53 Ant. tart., ,.........72 Apis,...........80-81 Ars. alb.,......108-109 Bell.,............119 Bry. alb.,..........134 Cann. Ind...........148 Chin.............183 Chin, sul.,..........191 Crotal.,.........228-229 Gels.,...........254-256 Kali chlor...........286 Opi.,............304 FEVERS, ERUPTIVE: (See Exanthemata.) FEVER, INTERMITTENT: Amyl nit.,..........65 Apis,............81 Ars. alb.,..........108 Chin.,............183 Chin, sul............191 Gels.,............256 FEVER, MALARIAL: Apis.............8r Ars. alb.,..........108 Chin.,..........183 Chin, sul............191 Gels.,.......... 265 Opi..........• • • . 304 FEVER, REMITTENT: Ars. alb............108 Crotal............228 FEVER, SCARLET: Aeon.,............34 Ailanth.,..........53 Ars. alb.,..........100 Bell.,............119 Kali chlor...........286 FEVER, TYPHOID: Agar, muse,.........49 Ars. alb.,..........109 Bell.,............119 Bry. alb............134 Cann. Ind...........148 Crotal.,...........228 Gels..............256 Opi.,............304 FEVER, TYPHUS: Crotal.,...........229 FEVER, YELLOW: Ars. alb.,..........109 Crotal.,...........228 FLUSHES: Amyl nit.,.........65 FRIGHT, EFFECTS OF: Aeon.,...........31 Gels.,............253 GANGRENE: Crotal., . . 227 GASTRALGIA: Acid, hydroc, ........ 10 Arn............-95 Gels..............255 GASTRIC CATARRH: (See Gastritis.) GASTRIC DERANGEMENTS: Acid, hydroc,......• 10 Acid, oxal.,.........14 Ant. tart.,..........72 Arn.,............95 Ars. alb.,....... 102-103 Brom.,...........124 33§ THERAPEUTIC INDEX. Bry. alb.,..........133 Carbo veg.,.........167 Cham.,...........171 Chelid.,...........178 Gels.,............255 Kali bi.,...........275 Kali chlor.,........ 286 GASTRITIS: Acid, oxal.,.........14 Ant. tart.,..........72 Arn.,............95 Chelid.,...........178 Kali chlor.,.........286 GASTRODYNIA: (See Gastralgia.) GENERAL DEBILITY: (See Debility, General.) GLANDS, INGUINAL, IN- FLAMMATION OF: Clemat,..........200 GLAND, PROSTATE, DIS- TURBANCE OF: Thuja,...........317 GLAUCOMA: Aeon., ...........31 GLOSSITIS: Acid. oxal..........13 GONORRHOEA: Aeon.,...........32 Arg. nit............89 Camph.,..........138 Canth.,...........155 Clemat............200 Thuja,...........317 GOUT: Chin, sul.,.........191 GOUTY OR RHEUMATIC HEADACHE: Coloc.............221 GRIEF, EFFECTS OF: Gels.,...........253 HEMOPTYSIS: Aeon.,...........33 Arn.,............94 HEMORRHAGE: Aeon.,...........33 Arn.,............94 Crotal.,...........227 Hamam.,..........265 HEMORRHAGE, PULMON- ARY: Arn.,............94 Crotal.,...........226 HEMORRHOIDS: Escul.,...........42 Aloes, ...........59 Hamam.,..........266 Thuja............316 HALLUCINATIONS: Bell.,..........112-116 Cann. Ind.,.........148 HEADACHE: Acid, carbol.......... 4 Acid, hydroc,.......9-10 Acid, oxal.,.........13 Acid, pic, .........21 Aeon.,...........31 Agar, muse,........48 Amyl nit...........65 Ant. tart.,..........69 Arn.,............94 Bell.,............116 Brom.,...........124 Bry. alb.,..........132 Cann. Ind.,.........149 Carbo sul.,.........161 Carbo veg.........167-168 Cham.,...........172 Chel.,............178 Chin.,...........182 Chin, sul.,.........190 Cic. vir.,..........194 Clemat.,..........199 Coca., ...........205 Cocc. cact,.........212 Coloc,...........221 Cyclam.,..........246 Gels.,............254 Glon.,............261 Hamam.,..........264 Hydras.,..........269 THERAPEUTIC INDEX. 339 Kali bi., ..........279 Kali chlor..........285 HEADACHE, CONGESTIVE: Acid, hydroc,.......10 Aeon.,...........31 Amyl nit.,..........65 Bell.,............116 Bry. alb.,..........132 Gels.,............254 HEADACHE, GOUTY OR RHEUMATIC: Coloc,...........221 HEART, DISTURBANCE OF: China,...........182 Coca.............205 Kali chlor..........285 Lit tig.............294 HEART, HYPERTROPHY OF: Aeon.,...........33 HEART, INJURIES TO: Arn.,............94 HEART, PAINS IN REGION OF: Acid, hydroc,.......9-10 Acid, oxal.,......... 13 Aeon.,...........33 Act. rac,..........37 Amyl nit............65 Apis,...........78 Cann. Ind.,.........146 Canth.,...........153 Lil. tig............292 HEART, PALPITATION OF: Aeon.,...........33 Chin.,...........182 HELMINTHIASIS: Sant, . . ........309 HEPATIC DERANGEMENT: Chelid.,..........178 Chin, sul...........191 HEPATITIS, ACUTE: Chelid.,...........178 HICCOUGH: Cic. vir.,..........194 HOARSENESS: Aeon.,...........32 Bry. alb.,..........132 Carbo veg.,.........167 Cocc. cact.,.........213 Thuja,...........317 HORDEOLUM: Carb. sul., .........162 HYDROCEPHALOID: Arg. nit.,..........89 HYDROCEPHALUS: Aeon.,...........26 Apis,............76 Bell.,............112 Bry. alb.,.........132 Canth.,...........151 Chin. sul...........186 Gels.............249 Opi.,............299 HYDROPHOBIA: Canth.,...........154 HYPEREMIA, PULMONARY: (See Pulmonary Hyperaemia.) HYPEREMIA, RETINAL: (See Retinal Hyperaemia.) HYPERTROPHY OF HEART: Aeon.,...........33 HYPOCHONDRIASIS: Ac. hydroc,........10 HYSTERIA: Ac. hydroc, ........10 ICTERUS: Cham.,...........173 Chelid.,...........178 INCIPIENT STRICTURE: (See Stricture, Incipient:) INDIGESTION: Acid, carbol.,........ 5 Acid, pic, ...... . 21 Act. rac,..........39 Agar, muse,.........48 Brom............ 124 Bry. alb.,..........133 34° THERAPEUTIC INDEX. Carbo veg.,.........167 Carb. sul............161 Cham.............173 Coloc.....' • •.....220 Crot. tig............235 INFANTS. TEETHING OF: Bell..............n8 Cham.............173 INFLAMMATION, CARDIAC: Bry. alb.,........ INFLAMMATION, MENIN- GEAL: (See Meningitis.) 134 INFLAMMATION DER: (See Cystitis.) OF BLAD- INFLAMMATION OF EYE: (See Conjunctivitis.) INFLAMMATION OF INGUI- NAL GLANDS: Clemat.,..........200 INFLAMMATION OF URETH- RA: (See Urethritis.) INFLAMMATION, UTERINE: (See Uterine Inflammation.) INFLUENZA: Act. rac,..... ... 39 Escul.,...........42 Ars. alb.,..........107 Brom.,...........124 Chelid.............178 INGUINAL GLANDS, INFLAM- MATION OF: Clemat.......... . 200 INJECTION TIVA: Thuja, . . OF CONJUNC- INJURIES, MECHANICAL Arn.,.......... INJURIES TO HEART: Arn............ 3i6 94 INSANE, PARALYSIS OF: Cann. Ind.,.........149 INSANITY: Cann. Ind..........148 INSOLATION: Bell.,............IJ7 Camph............138 Gels.,........... 254 Glon.,..........262 INSOMNIA: Acid, pie,..........21 Brom.,...........I23 ........189 .......205 .......293 ........302 Chin, sul., Coca, . . Lil. tig., Opi., . . INTERMITTENT FEVER: Amyl nit,.........65 Apis, . . Ars. alb., Chin., Chin. sul. Gels., . . INTESTINAL IRRITATION: Sant., .......... 81 108 183 191 256 309 INTOXICATION, ALCOHOLIC: Cann. Ind.,.........147 Gels..............255 IRITIS: Clemat,..........199 IRRITABLE HEART: Brv. alb.,..... 134 94 JAUNDICE: Cham.,..........173 Chelid.............178 KERATITIS: Thuja,...........316 LARYNGISMUS STRIDULUS: Bell..............116 Cupr. acet.,.........241 THERAPEUTIC INDEX. 341 LARYNGITIS: Bell.,............II9 Bry. alb.,..........132 Carbo veg.,.........167 Carb. sul., .........162 LARYNX, AFFECTIONS OF: Bell.,..........114-119 Bry. alb.,..........i?2 Carbo veg...........^7 Carb. sul., .........T62 Cupr. acet.,.........241 Kalibi.,..........280 LEUCEMIA: Chin, sul., . . LEUCORRHCEA: Lil. tig., . . . . 190-191 LEUCOCYTHEMIA: (See Leucaemia.) LIVER DISEASES: Cham.,..........jj-i Chelid........... 178 Chin, sul.,.........iqi LOCOMOTOR ATAXIA: Acid pie.,..........21 Bell.,............Il6 LUMBAGO: Acid carbol.,........ 5 Aeon.,...........33 Carbo sul.,.........162 LUNGS, CONGESTION OF: Aeon.,........ Opi.,......... 33 303 81 108 183 191 MALARIAL FEVERS: Apis,........ Ars. alb.,....... Chin.,........, Chin, sul.,...... Crotal.............228 Gels.,............256 Opi.,...........304 MALIGNANT SCARLATINA: Crotal.,...........228 294 MANIA: Bell.,............116 Cann. Ind.,......... 148 Canth.,...........154 Cupr. acet...........241 MANIA-A-POTU: Bell....... 116 MASTURBATION: Acid, pic,..........21 MEASLES: Aeon.,...........34 Ailanth.,..........53 Gels.,............256 MECHANICAL INJURIES: Arn.,............94 MELANCHOLY: Cyclam.,..........246 MEMBRANOUS CROUP: Kalibi.,..........281 MENINGITIS: Bry. alb.,..........132 Cupr. acet., . •.......241 MENINGITIS CEREBRO-SPI- NALIS: Cic. vir.,..........194 Crotal.............227 Gels..............254 MENSTRUAL DERANGE- MENTS: Cyclam.,..........246 Glon., . . . . •......262 MENTAL DISTURBANCE: Bell.,..........112-116 Cann. Ind.,.....143-144-148 Canth............154 Cupr. acet.,.........241 Lil. tig.,........294 °pi->............303 MIGRAINE: Ac. carbol.,........4 Bell.............117 MORBILLI: Aeon.,...........34 342 THERAPEUTIC INDEX. Ailanth.,..........53 Gels.,............256 MORBUS BRIGHTII: Ars. alb.,..........108 Cann. Ind.,.........149 Canth.,...........155 MOTOR AFFECTIONS: Bell..............116 Gels.,..........254-255 MYALGIA: Act. rac,..........39 Carb. sul...........162 Gels.,............256 MYELITIS: Arn.,............95 NASAL CATARRH: Aeon.,...........31 Escul.............42 Bry. alb.,.........132 Hydras.,..........269 Kali bi.,..........280 NEPHRITIS: Ars. alb.,..........107 Bry. alb.,..........134 Canth.,.........• • 155 Chelid.,...........178 Kali chlor.,.........286 NEPHRITIS, SCARLATINAL: Ars. alb.,..........109 NERVOUS ASTHMA: Cupr. acet...........242 NERVOUS COLIC: Coloc.............220 NERVOUS PROSTRATION: Arg. nit.,..........87 NERVOUS SYSTEM, DE- RANGEMENTS OF: Arg. nit.,..........87 Bell.,.......• .... 116 Cann. Ind.,.......148-149 Coca.............204 Cupr. acet,.........241 Gels..............253 NEURALGIA Aeon...........n-33 Act. rac,.........38 Arg. nit.,..........88 Bell.,............H7 Cann. Ind.,.........T49 Coloc,...........221 Gels.,............255 OCULAR TROUBLES: Acid pie,..........21 Aeon.,..........31 Arg. nit.,......... 88 Ars. alb.,......... 106 Bell.,........... H7 Canth.,...........154 Cyclam.,..........246 Kali bi.,..........280 Opi.,............305 Sant.,........... 3°9 Thuja,...........316 CEDEMA: Apis,............80 Ars. alb.,..........106 EDEMA GLOTTTDIS: Apis,............81 EDEMA, PULMONARY: Apis,............81 OPHTHALMIA, STRUMOUS: Bell.,............117 OPHTHALMIC DISTURBANCE: (See Ocular Troubles.) ORCHITIS: Clemat,..........200 Hamam.,..........266 OVARIAN CONGESTION: Aloes,............60 Lil. tig.,..........294 OVARIAN NEURALGIA: Coloc,...........221 OVARIES, AFFECTIONS OF: Aloes,............60 Coloc,...........221 Lil. tig.,..........294 THERAPEUTIC INDEX. 343 OZENA: Kali bi...........280 PALPITATION OF HEART: Acid, hydroc,........10 Aeon.,...........33 Act. rac............37 Agar, muse, .......47 Apis,............78 Arg. nit.,..........86 Canth. .........153 Cham.,...........172 Chelid.............177 Chin.,...........^2 Chin, sul.,.........188 Coca,............205 Cocc. cact.,.........211 Glon.,...........260 Lil. tig.,..........295 ThuJa,...........314 PARALYSIS: Aeon.,...........3! Bell.,............u6 Cann. Ind.,.........149 Chin, sul.,..........190 Gels.,............254 OP1-.............303 PARALYSIS OF THE INSANE: Cann. Ind.,.........149 PARALYSIS, SPINAL: Bell.,............116 PELVIC CONGESTIONS: Aloes...........60 PERIODICITY OF SYMPTOMS: Thuja,...........318 PERITONITIS: Aeon.,...........32 Canth.,...........154 Coloc,...........220 PERTUSSIS: Aeon., ...........32 Bell.,............116 Chelid.,...........178 Cocc. cact.,.........213 Cupr. acet.,.........242 PLEURISY Aeon., . Bry. alb., Canth., . 33 133 154 PNEUMONIA: Acid, carbol.,........ 5 Aeon.,...........33 Escul.,...........42 Ant. tart............72 Brom.............124 Bry. alb., ... . ... 133 Chelid........ . . 178 Thuja,..........317 PNEUMONIA, CATARRHAL: Chelid.,...........179 PREGNANCY, VOMITING OF: Acid, carbol.,........ 5 PRIAPISM: Acid, pic,..........21 Canth.............153 PROSTATE GLAND, DISTURB- ANCE OF: Thuja,...........317 PRURITUS VULVE: Canth.,...........155 PROSTRATION, NERVOUS: Arg. nit.,......... 87 PTOSIS: Gels., ..........255 PUERPERAL CONVULSIONS: Bell.,............116 PULMONARY CONGESTION: Aeon.,...........33 Opi.,............303 PULMONARY HEMORRHAGE: Arn.,...........94 Crotal.,...........226 PULMONARY EDEMA: Apis,............81 PURPURA HEMORRHAGICA: Crotal.,..........229 344 THERAPEUTIC INDEX. REMITTENT FEVER: Ars. alb., .... ... 108 Crotal.,...........228 RENAL CALCULI: Canth.,...........155 RESPIRATORY MUCOUS MEM- BRANE, CATARRH OF: Aeon., .... ......31 Escul.,...........42 Brom.............124 Bry. alb.,..........132 Carb. sul., .........162 Carbo veg., . . .....167 Chelid.,.......178-179 RESPIRATORY TRACT AF- FECTIONS: Acid, carbol..........3-5 Acid, hydroc,........10 Acid, oxal.,.........14 Aeon.,...........31 Escul.,...........42 Ant. tart.,..........72 Apis,...........80-81 Bell.,............119 Brom.,...........124 Bry. alb., . ........132 Canth.,...........154 Carbo veg., .......167 Carb. sul.,......... 162 Chelid.,..........178-179 Cocc. cact,.........213 Cupr. acet.,.......241-242 Cyclam.,..........246 Hamam.,..........266 Hydras.,..........269 Kalibi.,........280-281 Kali chlor.,.......285-286 °pi-............303 Thuja,...........317 RETINAL HYPEREMIA: Bell.,...........117 RHEUMATIC OR GOUTY HEADACHE: Coloc.............221 RHEUMATISM- Aeon.,...........33 Act. rac.......... 39 Agar, muse,........48 Apis,............81 Arn.,............95 Bry. alb............134 Chin, sul.,.........191 Clemat.,..........200 Cocc. cact.,.........212 Gels.,............256 Kalibi............278 Thuja,...........286 SATYRIASIS: Ac. pie,..........21 SCARLATINA: Aeon.............34 Ars. alb.,..........109 Bell..............119 Crotal.,...........228 Kali chlor.,.........286 SCARLATINA MALIGNA: Crotal.,...........228 SCIATICA: Coloc,...........221 SENILIS, CATARRHALIS: Cann. Ind.,.........149 SHOCK: Arn.,............94 SKIN, DISEASES OF: (See Cutaneous Diseases.) SKIN ERUPTION: (See Cutaneous Eruptions.) SMALL-POX: Ant. tart.,..........72 Ars.,...........109 Crotal.,...........229 Kali bi............279 SORE THROAT: (See Angina Faucium.) STRICTURE, INCIPIENT: Clem, erecta.........200 THERAPEUTIC INDEX. 345 TOOTHACHE: Acid, oxal.,.........13 Bell.,............117 Cham.,...........172 Clemat,..........200 TORTICOLLIS: Aeon.,...........33 Act. rac,..........39 Thuja,...........318 TRACHEA, ACUTE CATARRH OF: Acid, hydroc,........10 Escul.,...........42 Apis.............78 Arg. nit.,..........86 Carbo veg.,.........167 Chelid.,...........178 Cocc. cact...........213 Gels..............251 TRACHEA, AFFECTIONS OF: Acid hydroc,........10 Escul.,...........42 Apis,............78 Arg. nit,..........86 Carbo veg.,.........167 Chelid.,...........178 Cocc. cact.,.........213 Gels.,............251 Kalibi.,..........280 TRAUMATIC ERYSIPELAS: (See Erysipelas, Traumatic.) TRISMUS: Cupr. acet,.........241 TROUBLES, OCULAR: (See Ocular Troubles.) TYPHOID FEVER: Agar, muse,........49 Ars. alb............T09 Bry. alb............134 Cann. Ind.,.........148 Crotal.,...........228 Gels., ...........256 Opi.,............304 TYPHUS FEVER: Crotal.,...........229 UREMIC COMA: Acid, carbol., . URETHRA, INFLAMMATION OF: (See Urethritis.) URETHRITIS: Aeon.,...........32 Arg. nit.,..........89 Camph.,..........138 Canth.,...........155 Clemat.,.......• • ■ 200 Thuja,...........3T7 URINARY AFFECTIONS: Acid, carbol.,........3-5 Acid, hydroc,........ 8 Acid, oxal.,.........12 Acid. pic...........18-19 Agar, muse,.......46-47 Ant. tart., ........70-72 Apis,...........78-80 Arg. nit.,..........89 Ars. alb.,........107-108 Bell.,............118 Bry. alb.,..........134 Cann. Ind.,.......146-149 Canth., ..........155 Chelid., ..........178 Chin. sul.........188-191 Clemat.,..........198 Cocc. cact,..... ... 213 Coloc,...........221 Crot. tig.,..........233 Hamam.,..........266 Kalibi.,..........281 Kali chlor.,..... ... 286 Sant.,............309 Thuja............314 URINARY DIFFICULTIES: (See Urinary Affections.) URINARY ORGANS, DIS- EASES OF: Ant. tart.,..........72 Apis,............80 Arg. nit............89 Ars. alb.,........107-108 Bell.,............118 3+6 THERAPEUTIC INDEX. Bry. alb.,..........134 Canth.,...........149 Chelid.,.......' .... 178 Clemat.,..........198 Cocc. cact.,.........213 Coloc,...........221 Kal bi.,...........281 Kali chlor., .........286 Thuja,...........314 URINARY TRACT, DISEASES OF: (See Urinary Organs, Diseases of.) URTICARIA: Act. rac,,..........39 Apis,............80 Carb. sill., .........162 Kali chlor...........286 UTERINE INFLAMMATION: Bell.,............119 UTERINE MAL-POSITION: Lil. tig.,..........294 UTERUS, ANTEVERSION OF: Lil. tig.,..........294 UTERUS, CONGESTION OF: Aloes,............60 VARICELLA: Ant. tart.,........_. . 72 VARICOSIS: Hamam.,..........266 VARIOLA: Ant. tart.,..........72 Ars. alb.,..........109 Crotal.,...........229 Kali bi.,..........279 VERTIGO: Acid, carbol.,........ 2 Acid, hydroc,.......10 Acid, oxal.,.........12 Acid, pie,.........17 Aeon.,...........31 Act. rac,..........36 Escul. hip.,.........41 Agar, muse,........45 Ailanth.,..........51 Aloes, ....••.....56 Ant. tart.,..........69 Apis,............76 Arg. nit.,..........84 Arn............91 Ars. alb.,..........101 Bell.,............116 Brom.,...........124 Bry. alb., ..........126 Camph., ..........138 Cann. Ind.,.........149 Canth.,...........151 Carb. sul., .........158 Carbo veg...........165 Cham.,...........170 Chelid.,...........175 Chin, sul.,.........190 Cic. vir.,..........193 Chem. erect.,........197 Coca,...........20 Crotal.,...........224 Crot. tig.,..........231 Cupr. acet.,.........238 Cyc Europ.,........244 Gels.,............254 Glon.,...........258 Hamam.,..........264 Kali bi., ..........247 Kali chlor.,.........283 Lil. tig.,..........291 Opi.............299 Thuja,...........312 VESICULAR ERUPTIONS: (See Eruptions, Vescular.) VEXATION, EFFECTS OF: Aeon.,...........31 VOMIT, BLACK: (See Black Vomit.) VOMITING OF PREGNANCY: Acid, carbol.,........ 5 WARTS: Thuja, 317 THERAPEUTIC INDEX. 347 WHOOPING COUGH: (See Pertussis.) WORMS: Sant., ....... YELLOW FEVER: Ars. alb.,..........109 Crotal.,...........228 309 i >\ m Kpy && NATIONAL LIBRARY OF MEDICINE NLM 00103580 D NLM001035800