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■"'V: - 
_____&L
UNITED STATES  OF AMERICA
FOUNDED 1836
WASHINGTON,  D. C.
 
\ 
 
A tROSP£or  of Extlrz'H FATING the Small-Pox ;
                 ■BEING
•r.iE HISTORY of the VARIOL/E VACCINAE,
                      OR

           KINE-POX,

             COMMONLY CALLED  THE
               COW-POX 5
         as ir has Appeared in England :
 V/ilh an Account of a furies of Inoculations .performed for the
           Kins-P'jx, in Massachusetts.
r.'JB_WJ«
       ••.•f\JAMIM WATKRHOUSE, «i. o.
1.0»V O •■ TDK AMERICAN PHIItfS. SOC'tTV J ACAD. ATT!
•t s.' ip;;ces; mass. mku. a.;d royai,  med. socis.
 LJMjU;, ; PHYSICAL At- .'J LITERARY S^Cl'iTY AT
  V.^'CHESTEil ', VIIILOS.ASD UTtKARY SOCI-
    ./t v /!•  au-r;; and  professor of the
      TiU.ORY AND PRACTICE OF  PHYSIC
        IK  THE  UNIVERSITY OF  CAM-
                BRIDGE.
  Fa&s like ihefe fneak fo ftrongly, and Co clearly, that reafomng
.lid argume.it mud be quite furerfluous.
       Bifiiop Maddox's iamon in favour of Inoculation.
liliMBW M IHM
55CBS3S SSSTS
  {   ♦     PRINTED FOR THE AUTHOR,
A, the t abridge Press, by WILLIAM HILLIARD, and
     Soli by him, and the other Bookfellers in Boston.
                     1800.                * .*

         (Copy-right fecured acccc-rding to law.) 
+  y
  -..*> 

         THE  HISTORY  OF THE


                KINE-POX*


               COMMONLY CALLED  THE


                 COW-POX.


           ------------    ■ ii iinn i in


                    CHAP.  I.

     AN the begumipg of ifieyeur 1799, I received

from my friend Dr. Lettsom of London, a copy of

 Dr. Edward  Jenner's " inquiry into the caufes and

<lffeds  of the Variola Vaccina  or Cow-Pox"; a

difeafe totally unknown in this quarter of the world.

On perufing this work,  I was (truck with the unfpeak-

 able advantages that might accrue to  this country,

   *  From Kine the plural of cow ;  thus in the fcriptures—" and
 they took two mikh-kine—and '{hut up their calves at home ;" a
 word equally expreflive, and in the opinion of fome, more de-
licate.
   Some in this country as well as in England,  after having all
their objections obviated, have faid,  " allowing  this co<w or kine-
pox to be at prefcnt benehcial^can any perfon fay what may be the
tonfequences of introducing  a heftial humour into the  human
frame after a long lapfe of years ;"'   Let us pufh  this wife obier-
 vation a little further ; and afk " who can tell what may be  the
tonfequer.ces, after a long lapie of years, of introducing into the
human fiamt ccvo's milk., hecffleaki, or a mutton-chop \"
   , _        .   See R1 n g's Obfervations on Dr. Mo s e l*.. 
                     [   4  ]
 and indeed to the human race at large, from the  "lif.
 covery of a mild di(temper that would ever after fr  .io
 the conftitution from that terrible fcourge, the fmall-
 pox.  My attention was not the lefs awakened by a
 previous impreffion that the fmall-pox came originally
 from the brute creation ; for all  that I could recollect.
 of the hiftory of the famous Mahomet, and his fuc-
 ceffor, and of modern Arabia, cqnfpired to  flrength-
 en the idea that the fmall-pox came to the human race
 through the brute creation.

  Dr. George Pearson's book, which I  received
 foon after that of Dr.  Jenner's, confirmed in a fatis-
factory manner the mofl important part of Jenner's
doctrine.

  As the ordinary mode of communicating even me-
 dical difcoveries in this country  is by news-papers, I
 drew up the following account of the cow-pox^ which
 was printed in the  Columbian Centinel, March i2th?
 *799'
    something curious in the medical line.
  EVERY body has heard of thofe diftempers, ac-
 companied with pocks or puftles, called the fmallpox,
 the chicken-pox and the fwine-pox, but  few have ever
 heard of the cow-pox, or if you  like the term better,
 the cow fmall-pox ; or to exprefs it in technical lan-
 guage, the varitla vaccina.   There is;  however, fuch 
                     [  5   ]
a difeafe, which has been noticed here and there in fe-,
veral parts of England, more particularly in Gloucef-
terftiire, for fixty or ieventy years pan, but has never
been an objecl of medical inquiry until very lately.

   This  variola; vaccina or  cow-pox^ is very  readily
communicated to thofe who milk cows infected with
it.   This malady appears firft on the teats of the cows
in the form of irregular puftles or pocks.*   They are
commonly of a palifh blue, fomewhat approaching to
livid, and furrounded by aneryfipelatous inflammation,
refembling the St. Anthony's fire.  Thefe puftles, un-
lefs timely remedied, degenerate into thofe ragged ul-
cers known by the furgeons under the name of phage-
denic.   The cows foon become fick, and the fecretion
of milk is  leffened, but I never heard of  one dying
with it.   Thofe who milk cows thus effected, feldom
or ever fail catching the diftcmper, if there be cracks,
wounds, or abrqfions  in the hands.  That is  to  fay,
they are inoculated.   When infected, there appear on
different parts of the hands and wrifts, inflamed fpots,
having the appearance of blifters, produced by burns.
Thefe run  quickly on to fuppuration.   Thefe fuper-
ficial fuppurations have a circular form with their edg-
es more elevated than the centre, very much  refem-
bling a certain ftage of the fmall-pox.   Thefe depreff-
cd puftles or pocks, are of a colour approaching tq
  * See Jenni:r, n. 3. & 4. 
                     f   6  j
 blue.   Abforption now  takes place, and a forenefa
 and fometimes tumors appear in the arm pits.  Theij
 the  arterial fyftem  becomes afFe&ed;  the pulfe is
 quickened, and fhivering with a general  laffitude and
 pains in the back  and limbs fupervene, and thefe fymp-
 toms are not unfrequently accompanied  with vomit-
 ing.  There is too, a pain in the head  and dizzinefs.
 Thefe fymptoms varying in their degrees and violence,
 generally  continue from  one day to three or four„
 leaving ulcerated fores about the  hands, refembling
 thofe on the cows teats, from  whence they fprung.
 The lips, noftrils and eye-lids are  fometimes affefted
with fores, but thefe evidently arife from their being
 nibbed or fcratched with the patient's infe&ed fingers.
 This is the common courfe of the difeafe with the hu-
 man fpecies.  No perfon was ever finown to  die  of
this dijlemper.  But what makes this newly discover-
ed diieafe fo very curious, and fo extremely important
 is, that every perfon thus affeQed, is EVER AFTER
 SECURED FROM THE ORDINARY SMALL-
 POX, lei him be ever fo much expofed to the effluvium
 of it, or let ever fo  much ripe matter be inferted into
 the fkin by inoculation.   In other words—a perfon
 who has  undergone the local difeafe and fpecific fe-
 ver occa/ioned by  the cow-pox infection, is thereby.
 rendered ever after unfufceptible of the fmall pox.*  I*
 is worthy of remark that the infeftion of the cow-pox
  * See Dr. Pearson's publication. 
[  7   J
can be conveyed to the human fpecies by the ordinary
mode of inoculation.   And it is obferved, that there is
no difference in the effects of the matter taken from
the cow, and of the matter generated fucceflively in
the fecond, third, fourth or fifth human creature.

   Such are the  outlines of a mild difeafe, the know-
ledge of which may lead to confequences of the utmoft
importance to the whole human race, no lefs indeed
than that of fuperceding, if not extinguifhing^  that terri-
ble fcourge, the fmall-pox.

   Dr.  Edward Jenner, is the phyfician in England,
who has colle&ed and arranged  a feries of fafts and
experiments refpeBing the difeafe called there the cow-
pox.  His fliort work is commented on by Dr.  George
Pearson, phyfician to St. George's hofpital, London.

   This imperfea (ketch is thrown into the news-paper
at this time, with a view of exciting the attention of
our dairy farmers to fuch a diftemper  among their
cows.  It may alfo be gratifying to fome of the facul-
ty of medicine, who, it is prefumed, are not yet gen-
erally informed of an  epizootic difeafe, capable of be-
ing communicated from the brute to the human kind,
and which when communicated, is a certain fecurity a-
gainft the fmall-pox.   The public anxiety has  been
 roufed of late: to fearch after the caufe of a  deftrua- 
                     [  8  J
 ive fever.   Their attention has  been directed  merely
 to effluvia, vapours or gaffes, while they may here fee
 a difeafe, the nearefi a kin to the fmall-pox of any yet
 known, which is never communicated bv  effluvia, or
 medium of the air.   It is highly probable tb*t f)rn*:
 of the mod diftreffmg difeafes which  afflicl man-
 kind, have  an  animal origin; and time may  prove,
 that fmall-pox, whooping-cough, and one kind  oi'
 quincy, have like the hydrophobia, a {imilar fource;
   Cambridge, March, 12, 1799.

   This publication fhared the fate of mod others on
 new difcoveries.  A few received it as a very impor-
 tant difcovery, highly interefting to humanity; fome
 doubted it;  others  obferved that wife and prudent
 conduct, which allows them to condemn or  applaud,
 as the event might prove ; while a greater number ab-
 folutely ridiculed it as one  of thofe medical whims
 which arife to-day and to-morrow are no more.

   At a meeting of the American Academy of Arts
 and Sciences, held  a few weeks after, in one of the
 rooms  of this Univerfity, I communicated  what I
 knew of this novel diftemper, by exhibiting Dr. Jen'-
 ner's beautiful publication, and recapitulating as ma-
ny of the moll prominent parts of Dr. Pearson's book
 as I could recollect, for I had lent and loft the work
 itfelf.  The reception of this   communication  was 
[  9   ]
much to my fatisfa&ion, efpecially with the illustri-
ous  President, who to a profound erudition in laws
and  politics, joins a no fmall knowledge in the fci-
ence'of medicine*.

   When  this verbal  communication was  made,  I
promifed  to  prepare a memoir on the fubjec\ by the
next quarterly meeting.  But before that period ar-
rived, Dr. Woodvill's publication came to my hands,
which I found fo entirely to the purpofe, that I with-
held my memoir, and  prefented the Academy with
the  book  itfelf,  as  containing a chain of  experi-
ments and faclsj  arranged in the form of a table, vaft-
ly beyond what I could procure elfe  where.   This
publication is entitled,  " Reports of aferies  of in-
oculations for the Variola Vaccina, or Cow-Pox,
with remarks and obfervations on this  difeafe, con/ider-
edas a fubftitute for the fmall-pox, by William Wood-
ville, M.  D. Phyfician to the fmall-pox and InoculaU
ing Hofpitals in the city of London."

   This work I found contained juft what I wiflied,
a feries of experiments, condu&ed by a learned phy-
               B

  * Left this fhould ever be read beyond the bounds of this Con-
tinent, it will not be fuperfluous to add here, that the Presi-
dent of the American  Academy of Arts  and Scien-
ces  is JOHN ADAMS, President  of these United
States, 
                    r  10   ]
iician, long con vcrfant with the carnal arid inoculated
fmall-pox, in thelargcft city in the world.  The pub-
lication  bore an  additional weight from the. opinion
given in-., by Dr. Haygarth of the book and of ifs au-
thor ; there being no man  now on the ftage more tho-
roughly acquainted with the laws of contagion than
Dr. Haygarth.   From this publication of Dr. Wood*
vill's, was formed, in a great meafure, my fecondcom_
uunication, which I made, like the fir ft, through the
vncdium of a  news-paper.  It is this which follows :

                  COW-POX.
   THE curioftty of the public has been excited hy
a  newly difcovereJ difeafe, denominated  from its
 GigirG the cow-pox, an account  of which I  fent you
laft March.   By  the hiflory then given, it  appeared
that this cow-pox pretty exactly  refembles  the very
mildeft  fmall-pox from inoculation ;  that none had
fiver died of it, whether man or beaft;  and that thofe
Who  had undergone the cow-pox, were ever  after
stxured from the small-pox,  be they ever fo much
cxpofed  to  the effluvium of it, or ever fo much ripe
matter inferted into the fkin  by  inoculation ;  or  in
other words,  that  thofe perfons  who had i.  legoive
ihe local difeafe and fpecific fever occafioned by the
cow-pox .infection, are  thereby rendered ever  after un-
f.fceptiblc of the frirdl-pox,   Many parents are doubt- 
                 .   [   '1   ]
 leis anxious to know if thefe aflertions are j unified bv
 fuhfequent experiments,  and fubftantiated by a well
 aoeaoiac! chain of fa£is.   I now lend you what infor-
 mation I have  gathered  from my correspondents in
 England. ;:nd from various publications, efpeciaPy
 irom one by Dr. Woodyille, on this all important
 fubjea.

   Dr. Woodyille is phyfician  to the fmall-pox and
 inoculating hofpitals in the city of London.  It feems,
 that  finding  by  Dr.  Jenxer's  original publication,
 that  no fatal eftecls had ever  been known to follow
 from the cow-pox, and that it left the conftitution in
 a ftate of perfect fecurity from  the  infeclion of the
 fmall-pox,  Dr. Woodville became  very anxious to
 try the effects of inoculating  the matter  cf  this new
and lingular difeafe ; and as trials could be made not
only with  fafety,  but  alfo with a profpecr to advan-
tage, he conceived it to be a duty that he owed the
public in his official fituation at the inoculating hofpital,
to embrace the fir ft opportunity  of carrying the plan
into execution.

  He found the difeafe at a  cow-houfe in Gray's In-
 Lane, where there were about 200 cows kept.  On<
 of the milkers, named Sarah  Rice, had  fo perfect a
fpecimen of the  diftemper on her hands, that Dr. 
                     [  12   j  .

 Woodville  entertained no  doubt of its  being  the
 genuine cow-pox.   It very much refembled the re-
 prefentation given in the firft plate of Dr. Jenner's
 publication.  Dr. Woodville, therefore, in Janua-
 ry laft, went |o that  cow-houfe,  in company with
 Lord Somerville,  Sir Joseph Banks, Sir William
•Watson, Drs. Simmons, Pearson, Wellan, and o-
 thers, and took fome of the purulent matter from the
 teats of the cow, and from Sarah Rice, with which
 he immediately inoculated  feven children, by fcratcru
 ing the (kin with the point of a lancet till the inftru-
 ment became  tinged with blood.  In the  courfe of
 three months,  Dr. Woodville inoculated two hun-
 dred, whofe cafes he has given in his pamphlet.   By
 the month of May, he had  inoculated obout fix hun-
 dred,  and  has exhibited the refult as it regarded
 the number of puftles, days of illnefs, &c. in the form
of a table.   Nearly all thofe perfons were afterwards
inoculated with matter of fmall-pox, or elfe expofed to the
infedionofit in the fmall-pox hofpital, without the leajl
figns  of the difeafe.   The Dr. then points out where
thefe two difeafes agree, and in what they differ.  The
cow-pox, he obferves, in every  cafe with which we
are as yet acquainted, has  been  introduced into the
human conftitution through the  medium of external
local inflammation, and is therefore to be confidered
as 
                    |[   *3  ]
an inoculated difeafe ; for there are no clear inftances
of its being received by effluvia, as is the fmall-pox.
neverthelefs its virus feems  to afFeft a  fimilar mode
of action,  and to be  governed by the fame laws.
Thus, if a perfon be inoculated alternately with the
fmall-pox matter, and that of the cow-pox every day,
till fever is excited, all the  inoculations make a pro,
grefs; and as foon as the whole fyftem becomes difor^.
dered, they appear to be all equally  advanced in mu.
turation.   It is to be remembered, that the local tu-
mor excited from the inoculation of the cow-pox, is
commonly of a different appearance from that which
is the confequence of the inoculation  with variolous
matter.  The fluid formed in the cow-pox tumor ve-
ry rarely becomes puriform,  and the fcabs which fuc-
ceed  are of a harder texture, and exhibit a fmoother
furface than the fmall-pox.*

   It is evident from Dr. Woodville's publication,
that the matter of the cow-pox has generally produc-
ed much fewer puftles  and lefs indifpofition, than  that
from the inoculated fmall-pox; for it  appears from
his fummary  or table, that about two fifths of all the
perfons inoculated for  the  cow-pox, had no puftles at
al^ and  that in not more than a fourth part of them
was  there  experienced  a perceptible  diforder.   But it
   *  See Dr. Woodvill's publication, 
                     [   M  3
 muft at the fame time  be acknowledged,t fays  Lj'.
 Woodville, that in  fcvcral inftances, the cow-pox
 has  proved a very fcvere difeafe.  Some  had 200,
 fome 300, and fome 500, and two had 1000 puftles.
 One infant at the bread  died on the eleventh day af-
 ter the cow-pox matter had been inferted into its arm.
 In this folitary fatal  cafe, the  local tumor  was verv
 flight, and the eruptive fymptoms took place on the
 feventh day, when the child was feized with convul-
 (ion  fits, which carried it off.   The puftles were from
 80 to 100.   Can we, however, be certain it died in
 confequence of inoculation ?  Finally, the inftances
 which have been  brought forward to prove, that thofe
 who  have  undergone the  cow-pox, refilled the infect-
 ion of the fmall-pox, are unquestionable and decisive?
 and  fufficiently numerous to  eftablifli  that important
 fact.   This circumftance, then, fays Dr. Woodville
 appears to be as much a  general law of the fyftem, as
 that a perfon having had the fmall-pox  is thereby ren-
 dered unfufceptible of receiving the difeafe  a  fecond
 time.  For all the patients, (bys he, whom  I have in-
 oculated with variolous matter, after they had paffed
 through the cow-pox, none  were affected  with  the
 fmall-pox ; and  it may  be remarked, that nearly a
fourth  part were fo (lightly affe&ed with the cow-pox,
 that  it neither produced any perceptible  indifpofi-
 tion  nor puftles. 
                     i   >5  i
    I  have thought it  not improper to throw thus
 much before the public at this time.  We live in
 the fcrutinizing asra of experiment,  and  we cannot
 doubt  but our brethren in England, will purfue this
 important fubjeQ with an indefatigability, charafter-
 iftic of the nation, and produce a ftill  longer chain
 of fafcls, which  feems abfolutely neceffary  before we
 can all unite in  the refolution to difcard the  inocula-
 tion of the fmall-pox, and adopt that of the  cow.
                          B. WATERHOUSE.
   Cambridge, Nov. 15, 1799.

   I now found that the  brief hiftory which I  had
 given of the origin and progrefs of this difeafe made a
 favorable impreflion on the minds of the people; for
 the dread of that terrible fcourge the fmall-pox is  ftill
 great in America, efpccially in New-England,  as is
 iufticiently obvious by  the numerous laws and regu-
 lations  for preventing its contagion, and  which  are
 all defcribed in my letter to Dr. Haygarth, printed in
 London in th^ year 1782, and glanced at  in feveral
 fubfcquent letters to be  found in  that gentlemans'
 *; fketch of a plan to  exterminate  the cafual fmall-pox
from Great Britain, printed at Warrington in 1792*
 and dedicated, by  permijfion, to the King."

   Perceiving that this difeafe began to  excite a  fpi-
 rit of enquiry among our literary men, I deemed it of 
t  16  ]
importance  to collect and examine every  thing that
had or might be publifhed on the  fubjecl,  and to ac-
quire, from  my correfpondents in England, every in-
formation reflecting a diftemper fo interefting to hu-
manity.

   As the great queftion which the profeffional public
were  anxious to have refolved was, whether a perfon
who  had been fairly infecied with the genuine cow or
kine-fox, were therebyfecured againfl the fmall-pox, I
bent all my enquiries to afcertain this point.

   It would  be fuperfluous to mention every queftiort
I put, and tedious to relate the  different anfwers re-
ceived.   Suffice it for the prefent to fay, that I made
my enquiries of phyficians living in different parts  of
Great-Britain, and  of thofe too who  were the leaft
fanguine, although moft interefted in the  event;  of
men, who objected much, and  believed ftowly, yet
have in the  end become  its  moft potent advocates.
And I do now deliberately  declare, that I have re-
ceived a croud of evidence  in  confirmation of the
doctrine, " that the cow, or kine-pox renders the hu-
man frame unfufceptible of the fmall-pox", too great
to be refifted by any mind not  perverted by  preju-
dice.   In truth, the fubject.  has been traced in Eng-
land, by thofe who doubted, until conviction became
too ftrong for argument^  and theoretical objections 
[  '7   ]
 gave way  to ftubborn  facts.  The confcquehce has
 been, that  thirty thousand perfons, from two weeks
 old and upwards, have paffed fafely through the dif-
 eafe.   Dr. Jenner has been particularly noticed by
 the King,  who gave him permiffion to dedicate the
 new edition of his book to him.

   But difiance of fpace operates on fome minds like'
 diftance of time.   People are not fo ready to believe
 what happened a great while ago, or a great way off*
 I  therefore found it  neceffary to bring the matter
 home to us, and  to  repeat  m  America the experi-
 ments  performed on the other fide  of the Atlantic.
 I  wi fhed alfo  to examine another .mportant fad, o£
 which  fome eminent phyficians  in London expreffed
 fome doubts, and which I myfelf was anxious to fee
 more  firmly eftablifhed, namely, whether  this new
 difeafe, this cow-pox, or kime-pox, (denominate  it
 which you will) be really not contagious, or catching
from one perfon to another.   And I do now affert, that
 from all the experiments hitherto made public, it clear-
 ly appears, that this fubflitute for  thefmill-pox cannot
 he  communicated by any other means than by the adual
 contact of matter ; or in other words, is not catch-
 ing from one perfon to another by effluvia,  like the fmall-
pox or measles.   Even the cows do not convey the dif-
 temper by  effluvia, or when there is a fence or hedge
              C 
                    r.   »8  ]
mterpofed between diem ; and not, fays Dr. Jenner?.
Uwlefs they be handled or milked by thofe'who bring
the infectious matter with them.*
v
                 CHAP.  II.

 %*J NDER a ferious impreffion of effecting a public
benefit, and conceiving it, moreover, a duty in my offi-
cial fituation in this Univerfity, I fent to England for
fome  of  the  vaccine  or  cow-pox-mattet  for  trial.
After feveral fruitlefs, attempts, I obtained fome by a
fiiort paffage from Briftol,  and with it I inoculated
all the younger part of my family.

   The firft of my children that I inoculated, was a
boy of five years old, named Daniel Oliver  Wa-
terhouse.  I made a (light incifion in  the  ufuaj
place for inoculation in the arm, inferted a fmall por-
tion of the infected thread, and covered it with a ftick-
ing-plafter.  It exhibited no other appearances  than
what would have arifen from any other extraneous
fubftance, until the  6th day,  when an encreafed red-
nefs  called forth my attention.   On  the 8th, he com-
plained of pain under the inoculated  arm, and on the
9th, the inoculated  part exhibited evident figns  of vi-
 ■ * $ee Tenner's'" further obfervations  on the Variol/E
Vaccina," 
                     [  '9   3
 iulency.   By the 10th, any one, much experience^ in.
 the inoculated fmall-pox, would have pronounced the
 arm infected.  The pain and fwelling under  his arm
 went on gradually encreafing, and by the  nth day
 irom inoculation, his febrile fymptoms were pretty
 ftrongly marked.  The fore in the arm proceeded exr
 aclly as Drs. Ienner  and Woodville defcribe, and
 appeared to the eye very like the fecond plate in Dr.
 Jenner's elegant publication.   In (hort, the appear-
 ance and  fymptoms of this difeafe, in the  old world,
 and in the  new, were more completely alike than I ex-
 pected.  From  the difference of fituation, greater
 drynefs of our atmofphere, and extraordinary heat of
'the weather, (from 8.8. to 96. of Farht.) I did expert
 a greater variation.

   The inoculated part in  this boy, was furrounded
 by an efflorefcence which extended from his fhoulder
 to  his elbow, which  made it neceflary to apply fome
 remedies to leffen it;  but the "fymptoms," as they are
 called,  fcarcely drew him from his play more than an
 hour or two; and he  went through the  difeafe in fo
 light a  manner, as hardly ever to exprefs any marts
 of peeviflinefs.   A piece of true (kin was fairly taketi
 out of the arm by the virus, the part appearing as if
 eaten out. by a cauftic, a never failing fign of thorough
 fection ofthefyflem in the inoculated fmall-pox. 
                    [so  ]

   Satisfied with the appearances  and fymptoms in
 this boy,  I inoculated another of three years  of age,
 with matter  taken from his  brother's arm, for he had
 no puftles on his  body.   He likewife went  through
 the difeafe in a  perfect and very  fatisfaclory manner.
 This child purfued his amufements with as  little in-
 terruption as his brother.  Then I inoculated a fer-
 vant boy of about 12 years of age, with fome  of the
 infected thread  from England.   His  arm was pretty
 fore, and  his "fymptoms ' pretty  fevere.   He treated
 himfelf rather harfhly by exercifing unneceffarily in
 the garden, when the   weather  was  extremely  hot
 (Farht. Thermr. 96, in the (hade !) and then waihing
his head and upper parts of his body under the pump,
 and fetting,  in fhort, all rules at defiance, in my ab-
sence.   Neverthelefs, this boy went through the dis-
 order without any other  accident than a  fore  throat
 and a (liffnefs of the mufcles of the neck, all  which
 foon vanifhed by the help of a few remedies,.

   Being obliged to go from home  a few  days, I re-
 queued my colleague  Dr.  Warren, to vifit thefe
children.  Dr.  Dan forth,  as well as fome other phy-
 ficians, came from Bofton out of curiofity, and  fo did
 feveral practitioners  from the country.   I  mention
 this, becaufe it  gaye rife to a groundlefs report, that
 one of the  children had  fo bad an  arm that  \ 
[  2l   3
thought it prudent to take the advice of fome  of my
brethren upon it.

   From a full matura;cd puftle in my  little boy cf
three years old, I inoculated, his infant  filter, already
weaned, of one year,  At the  fiune time, and from
the fame puftle, I inoculated its nurfery maid.  They
both went  through the difeafe wit,h equal regularity.
As this woman  was the firft adult perfon on whom I
had performed the operation, I was more conftant in
my enqufries, and more careful to note fymptoms as
they arofe.   They were veiy fimilar  to thofe of the
lighter kind from  inoculation for the  fmall-pox, viz.
a  flight dizzinefs and naufea, watery  eyes, chillinefs,
forenefs of the  flelh, ufually called  by the  common
people in this  country,  " bones -ache"\ a general laffi-
tude,  tranfient  pains in  the region of the  ftomach?
loins  and head, with a difinciination to animal  food
and exercife ; yet none  of thefe  fymptoms were fo
oppreflive as to diminifh for a moment her attention
to her little charge, whofe fymptoms, we conjectured,
kept pace with thofe  of its nurfe.

   This ftriking fimilarity of fymptoms has induced
fome  practitioners in this country, as  well as fome
phyficians in Great-Britain, to  conclude,  that the
hine-p9x was only a  variety  of the  fmall-pox.  We 
                   •[   «  3
cqnfefs they appear to be near a kin; yet fome circum-
ftances lead us to conclude them fpecifically different;
for example, we can communicate the vaccine poi-
fon to  any cow by inoculation, but  we cannot give
her by any method the fmall-pox.  This is not, how-
ever, peculiar to the cow—It is true  of every other
brute on  which the  trial  has  been  made; without
which  provifion in nature,  the  whole human race
might again differ under this terrific fcourge !

   I attempted to inoculate two more of our female
domeftics, but failed, owing probably  to ufing a new
method recommended by an eminent furgeon in Lon*
don, which was, to pafs a needle with an infected thread
through the fkin, fo as to leave the thread in.  This, it
is  probable, underwent an  alteration  fimilar to what
happens in the operation of wire-drawing, where moft
of the oil and fome of the metal are left behind.  Then
I performed the operation on four gentlemen, one of
them a phyfician, whofe fymptoms were  fo nearly a-
like what I have already related, that  I. find nothing
new to add, excepting that one of them chofe to live
pretty freely by way of experiment, and whofe febrile
fymptoms, efpecially the head-ache, were full as much
as he could bear and walk about.  This convinced me
that the Kim-pox was  a difeafe not to be  trifled
With.                                     *- 
t  n  ]
                CHAP.  III.

■JTIaVING thus traced the moft important facts re-
fpecting trie caufes and effects of the kine-pox up to their
fource in England,  and having confirmed  moft  of
them by actual experiment  in  America, one experi-
ment only remained behind to  complete the bufinefs.
To effect this, I wrote the following letter to Dr. As-
pinwall, phyfician  to  the fmall-pox hofpital in the
neighbourhood of Bofton.*

                     Cambridge, Aug. 2d, 1800.
   Dear Doctor,
     You have doubtlefs heard of the newly difcrib-
ed diforder, known  in  England by the name of the
ttfw-pox, which fo nearly refembles the fmall-pox, that
it is now agreed in Great-Britain, that the former will
pafs for the latter.
   I have collected every thing that has been printed,
and all the information I could procure from my cor-
refpondentsj refpecting this diftemper, and have been
fo thoroughly convinced of its importance to humani-
ty, that I have procured fome of the vaccine matter, and
  * See my account of his hofpital, in the 2d vol. of Dr. Hay-
garth's " {ketch and cprrafpondejoce/' printed at Warrington*
in England, 17921 
[  24   ]
therewith inoculated feven of my family.   The inocUJ
lation has proceeded in fix of them exactly as describ-
ed by Woodville and Jenner ; but my defire is to
confirm the doctrine by having fome of them  inocu-
lated by you.

  I can obtain variolous matter,  and inoculate therri
privately, but I wifh to do it in  the moft open and
public way pofiible,  As I have imported a new dif-
temper, I conceive that the public have a right to
know exactly every  ftep I take in it.   I write thisj
therefore, to enquire whether you will, on philanthrop-
ic principles, try the experiment of inoculating fome
©f my children who have already undergone the cow-
pox.  If you accede to my propofal, I fhall confider
it as an experiment in which we have co-operated for
the good of our fellow-citizens, and relate it as fuch in
the  pamplet I mean to publifh on the fubject.
                     I am, Sec.  Sec.
                                        B.  W,
Hon.  William Aspinwall, Efq.
          Brookline.

  To this letter the Dr. returned a polite anfwer, af-
furing me of his  readinefs to give any affiftance in
his power, to afcertain whether  the cow-pox would pre-
vent the fmall-pox ;  obferving,  that  he had at that 
                      [  H   ]
 time  frefh matter that he could depend on, and de-
 firing me to fend the children to the hofpital for  that
 purpofe.   Of the three which I offered* the Dr. chofe
 to try the experiment on the  boy of  12 years of age^
 mentioned in page 20, whom  he inoculated in my pre-
 fence  by two punctures,  and  with  matter taken  that*
 moment from  a  patient who  had it pretty full upon
 him.  He at the fame time, inferted an infected thread,
 and then put him into the hofpital,  where was one pa-
 tient with it the natural  way.  On the 4th day, the
 Dr. pronounced the arm to be infected.   It became
 every  hour forer, but in a day or two it dried off, and
 grew  well, without producing the  flighteft trace  of a
 difeafe ; fo that the  boy was difmiffed from the hof-
 pital and returned home the 12th day after the  expe-
 riment.   One  fact, in fuch cafes, is worth a thoufand
 arguments.*
   It  is  proper to mention, that there are fome  cir-
 cumftances, which if not  attended to  critically, may
 bring the inoculation of this recently imported diftem-
 per into  a temporary difrepute.  Dr.  Jenner, aware
 of fuch an accident, has  pointed out the  fallacious
 fouix.es whence a difeafe imitative of the variola vac-
cina, or kine-pox,  may arifc, with a view of prevent-
ing a fpurious difeafe.
               D
  * Five  more of my family,  including three of my children*
are now in Dr, As n« wall's  hofpital* 
                     [  26  ]
   Of the fources c f fpurious cow-pox, he enumerates,
   ift—That arifing from puftules on  the nipples, or
 udder of  the cow, which puftles contain no fpecific
 virus.
   adly—From matter, (although originally poffefling
 the fpecific virus,) which has fuffered a decompofition,
 either from putrefaction, or from any other caufe  lefs
 obvious to the fenfes.
   3dly—From matter taken  from an ulcer in an ad-
 vancedftage, which ulcer arofe from a true cow-pox.

   He then gives a ftriking inftance, where a practi-
 tioner was under the  neceffity of taking  fome fmall-
 pox-mattcr from a puftule, which  experience finCe
proved, was advanced too far  to anfwer  the purpofe
intended, and fays  that the fame may happen in the
cow-pox.

   He next (hews,  that when the inoculated part has
degenerated into an ulcer, the matter, although it may
poffefs the power  of inflaming the  patient's arm, is
ncverthelefs,  void of that fpecific  virus requifite to
produce the genuine difeafe ;  and of courfe, incapa-
ble of fecuringthe human fyftem againft the fmall-pox.

   He doubts whether pure pus, though  contained in a
fmall-pox  puftule, is ever  capable of producing  the
fmall-pox perfectly.  *{ I have often be?n foiled, fays 
                    [  »7   ]
" Dr. Jenner, in my endeavours to communicate
" the cow-pox by inoculation.   An inflammation will
i; fometimes fucceeds the fcratch or puncture, and in
" a few days difappears without producing any further
*6 effect.  Sometimes it will even produce an ichorous
" fluid, and yet thefyfilem will not be affected.   The
" fame thing, we know, happens in the fmall-pox."

  Three or four inftances of the kind are recorded
to have happened in England.   The children were in-
oculated for the  fmall-pox,  and  took the  diforder-
The oppofers to the introduction of the kine-pox have
yncandidly adduced thefe inftances, and they have been
repeated in this country, without any explanation, by
fome who were capable of explaining them'

  Another circumflance, tending to difcredit the idea
of difcarding the fmall-pox and fubftituting the kine-
pox, is mixing the  two difeafes together, and perhaps giv-
ing one for the other, as we prefume was done in fome
of the hofpitals in London.  A phyfician of the firft
rank, wrote thus to the author, in Feb. 1799.  " Dr.
** W. tells me, that he finds the cow-pox a more fe-
" rious difeafe than was at firft imagined 5 and  con-
*e fidering the fafety of inoculation,  (for  fmall-pox),
c6 and the danger of introducing a new difeafe into the
*■ human  frame,  probably the practice will not \\\-
66 cre^afe." 
                     r  *s   ]

   It  was juft about the fame time, that Dr.  Sims
 wrote the letter referred to in page 33, fo that the flat-
 tering profpect  of banifhing the fmall-pox forever
 from Great-Britain, feemed to be obfcured for feveral
 weeks.  But Dr. Jenner, and Mr. R-----, a very dif-
 tinguifhed furgeon and native of the county where the
 cow-pox  firft appeared, undertook to examine how it
 happened that a diftemper fo mild in Glocefterfhire,
 Jhould be converted  into a  pretty fevere  difeafe in
 JLondon.   This matter was unravelled, and the end of
 it appeared to be this: The  firft fubjects inoculated
 for the  kine-pox, were chiefly people  maintained as
poor.   They were inoculated at  the fmall-pox hofpi-
 pitals, and feveral of  them for both kinds, fmall-pox
 and kine-pox at the fame time, or at an interval of a
 day or two, by way of experiment;  and it is more
 than probable, fays one of my correfpondents, that a
 lancet infected wi(h variolous matter, was ufed for in-
 oculating for the kine-pox.   Be that as it may,  it is
 certain  that the patients of a celebrated  inoculator,
 had the difeafe with  greater  feverity than any other
 practitioner.   In general, the patients had more fever,
 forer arms, and more  puftules in London, than in the
 country.*  Thofe of the authors  friends who have
  * It may be neceflary to inform  fome of our readers, that the
 people cf England call every part of their Ifland ". the coun-
 try" out of London ; that city being called, by way of pre-
 eminence. " THE TOWN." 
                      [   *9  J
 urged him to eftablifh an hofpital for the kmc-pox,
 will  now fee  more  clearly,  the reafons for  not
 following their  advice.  An hofpital  might poffibly
 heighten a  very  mild diftemper into a  formidable
 difeafe.*
    After this fuccefsful inveftigation,  inoculation for
 the kine-pox went on with redoubled adivity; info-
 much, that from the date of Dr. Sims' letter, to May
 following, (juft about  a  year) 29,400 perfons of all
 ages,  pa(Ted  through the difeafe without a single
 DEATH !

    He who refleas on  the difference  of the two dif-
 eafes, the kine and the fmall-pox, the one contagious*
 the other not; the one not unfrequently attended with
 difagreeable confequences, and fometimes fatal, while
 the other is as little hazardous as the fwine or chick-
 en-pox—He,  I fay,  who compares  the two difeafes
 and their confequences, will not hefitate a moment in
 his preference.

   ?4 In  conftitutions predifpofed to fcrophula, fays
 Dr. Jenner,  how  frequently  we fee  the inoculated

    " ^r- Jenner told me, fays Dr. Lettsom, that his patients
in  the country have rarely more than one puftule.  So fays Mr.
R. who comes from  the fame neighbourhood.  He is fully of o-
pinion that the difeafe has been  mixed at the fmall-pox hofpital,
or  why fhould it differ fo effentially from the original difeale ia
the country ?'' 
                    [  3°   ]
fmall-pox roufe into activity this diftrefsful  mala-
dy.  There are many, who, from fome peculiarity in
the habit, refill the common  effects of the  fmall-pox
matter infertedin the fkin, and who are, in confequence^
haunted through life with the diftreffmg idea of being
infecure from fubfequent infection.   A ready mode,
fays he, of diftipating anxiety, originating  from fuch
a caufe, muft  now appear obvious ; for the conftitu-
tion may at any time be made to feel the febrile attack
of the cow-pox."*

  There is  another  circumftance of very  great mo-,
ment to fome families, I mean  thofe in  which the
fmall-pox always proves fatal, even under inoculation,
But this can be beft  enforced and illuftrated by the
better of Mr.  Walker, an eminent engraver  in  Lon-
don, addreffed to the editors of  the Medical and
Physical Journal, accompanied with a coloured en-
graving, reprefenting the diforder in the arm through
all its different ftages.t

  44 Having a fon between,  ten and  eleven months
old, and the fmall-pox being in my  oppofite, as well
as my next neighbour's  family,  I  conceived  it
fo unlikely for my infant to efcape the contagion, and
jtiaving heard  of the benign tendency and mildnefs of

  * See Jenner's inquiry, p. 70.  f Vol, :. p. u£, 
                     [   3'  1
 the cow-pox, I made it the fubject of particular enqui*
 ry, and from all I could  learn, there had  never  been
 known an inftance of its proving fatal.   On the other
 hand, I had experienced the fmall-pox in my own family,
 both natural and inoculated, to terminate mortally.   On
 thefe coniiderations, and admitting it fhould not have
 the defired effect of  a preventative  againft the fmall-
 pox, it would ftill leave my child  in the fame fituation
 as others ; but if it really were a prefervative, as it ap-
 pears  to  be in  numerous  inftances, the  advantage
 would be incalculable ; and, if encouraged, might  in
 the end even annihilate that  dreadful fcourge of man-
 kind, the fmall-pox.

   " To encourage others, I  tranfmit my obfervations,
 made  in the progrefs  of the diforder,  accompanied
 with a drawing,  exhibiting the various appearances of
 the puftules.

  "On Monday, 19th February 1799, the infection
was given by Dr. Woodville, in the prefence of Dr.
 Willan, by two incifions, Sec. Sec."   Then follows
an  account of the appearances (with nine  reprefenta-
tions  colored to the life, by  the  anxious  parent)
through the  whole difeafe, which we omit, as they ex-
hibit nothing new or extraordinary; and (hall add on-
ly the two laft paragraphs, which are thefe :

  '* On the 18th March; the whole fcab was feperat-
\ 
                     t  3*   1
in:! all round the ed.^es, and the child was inoculated
with  variolous  matter ie-r the common fmall-pox,
which on this day (March 21 ft.) is evidently dying a-
way like a fimple fcratch.

   " During the whole time, the child never  exhibit-
ed any particular fymptoms of indifpofition,  and had
fo little fever, that it was hardly, if at all, perceptible ;
he, however feemed by the motion of his arm, to  be
fenfible of a forenefs  under it; but neither that, nor
the eruption affected him  fo  much as to render him
crofs or peevifh, although he cut three teeth during the
progrefs of the diforder."
  London, Rofamond-Ureet, Clerken- "I
       well,  21 ft  March, 1799.    J
   The editors of this work, (which is one of the befl
medical reviews  in Europe), make this remark on the
above narrative  :  " The  preceding communication
<j on fo interefting a fubjec"t, we confider as peculiar-
" ly  valuable,   as Mr.  Walker  not  only (hews
6* a mind  fufficiently enlightened  to  give  a  fair
64 trial to a new  method  of conquering  one  of the
64 moft dreadful  fcourges to mankind, but from his
c: profefiional abilities, alfo enables us to exhibit the
" progreflive appearances  of the cow-pox."   See
Med. and Phys.  Journal, vol. ill. p.  120.

   Having adduced thus much in favor of this newly 
                    t  33  ]
 dcfcribed diftemper, it is agreeable to the candor we
 profefs, to inform the reader,  that one  phyfician of
 eminence,  and but one in London, has written a let-
 ter rather  againft the practice; I mean Dr.  John
 Sims.   It is grounded on an extract, of a letter from
 44 an intelligent gentleman, not of the profeffion," faying
 that "there is a gentleman of eminence in the law who
 has had the cow-pox twice,  which he caught by milk-
 ing his father's cows when a lad.  This gentleman was
 afterwards inoculated for the fmall-pox, and had it in
 fo  great abundance that his  life  was  difpaired of-
 44 He defcribes the cow-pox as  the moft  loathfome of
 difeafes, artd adds, that his right arm was in a ftate of
 eruption, both the firft and fecond time, from one ex-
 tremity to the  other;  the pain was cxceffive, and his
 fingers  fo  ftiff,  he could  fcarcely move them."—
 Nay, he fpeaks of the " abhorrence the difeafe created
 in the family."   Had  this gentleman been of the med-
 ical profeffion, he would have known, at once, that
 this was not the cow-pox, but an ulceration, (imilar to
 what Dr. J enner mentions in p. 8. Se g. of his 2d part.
 If this was the cow-pox, it was very different from any
ever feen fince.   It appears pretty  clearly, that this
gentleman, eminent  in the law, was under a miftake.
Dr. Sim's communication is dated Feb.  13th, 1799,
and may be feen in  the lft  vol. of the Medical and
 Physical  Journal  In a fecond letter in  the fame
              E 
                     C  U   1
 volume, which is explanatory and apologetical,  he
 fays, he had no intention of declaring  himfelf an ene-
 my  to the inoculation of this  difeafe; that his only
 wifli was, to induce the prafclitioners to paufe a little,
 '.o obtain more decided experience of its utility, be-
 fore it fhould be generally  recommended.  This  let-
 ter is dated April 20th, 1799, fin.ce which, decided ex-
perience of its utility has been obtained, and Dr. Sims is
 now among the firm advocates for the operation.  The
 reader,  however, is entreated to perufe thefe two let-
 ters, becaufe they have been quoted by fome who did
 not advert to their being written at fo early a period of
 the bufinefs.

   Dr. Mosely has raifed fomeobje8ions to the prac*
 tice ; but it would be unkind  to repeat them at this
 time.  We have glanced at fome of his notions in the
 note at the bottom of our firft page.   One idea of his,
 however, we cannot pafs over, becaufe that too has been
 repeated among us.   Coming  cloathed in the garb of
 prudence, we mult not treat it but refpectfully.   We
 allow, fay they, that the kine-pox fecures the  confti-
 tution from the fmall-pox for a fhort time,  becaufe
 that has been proved ; but  how do we know it will fe-
 cure it for a length of time.  Dr.  Mosely, fays Mr.
 Mr. Ring,* expreffes a fufpicion,  that the cow-pox
   * See Tvlid, and Phys. Journal, vol. 2d, p. 25. 
                     [   35  ]
 can  only render the habit unfufceptible of the fmall-,
 pox "for a time"  "This, obferves Mr. R. is refut-
 ed by volumes of evidence, and a cloud of witneffes."
 Perfons who repeat  this fufpicion of Dr. Mosely,
 fhould be informed of the number now living in the
 weftern counties of England, who have had the difeafe
 from milking cows in the  early part of life, and who
 have refifted every attempt to communicate the fmall-
 pox to them after the lapfe of i§, 20, 30, and even
 50 years and upwards.   Sec the cafe of Sarah Port-
 lock, who was inoculated  ineffectually for the fmall-
 pox tzventyfeven years after receiving  the infection of
 the kine-pox from milking cows ; of Mary Barge,
 thirty-one years ; of Elizabeth Wynne, thirty-eight
 years, and  above all, of John Phillips, FIFTY-
 THREE years after.  See alfo, feveral cafes in the
 ill and 2d volumes of the  Med. Se Phys. Journal.

   This was one of the moft formidable objections
 made againft inoculation for the fmall-pox, when firft
 practifed by Dr. Boylston in Bofton, in 1721.   Yet
 the long experience of eighty years has  now effectually
 removed every fufpicion of the kind.

   Although the inoculation for the cow-pox was not
received in  England,  without a degree of caution be-
coming an enlightened age  and people, yet it may be
afferted with truth, that nothing has occurred in the 
                         [  36   ]
     annals of medicine, which has been taken up more ge-
     nerally, received more candidly, or conducted more
     prudently.  And it cannot be fuppofed, that we Ame-
     ricans fhall give it a lefs candid reception, or exam-
     ine it lefs ingenuoufly.

       The people of New-England, particularly  ofBof-
     ton, fet a noble example to their elder brethren of
     Old-England, in adopting the Turkifh practice of in-
     oculation for the fmall-pox, in 1721.   Now, the Eng-
     lifh, in their turn, lead the way in a practice ftill more
     falutiferous.  For,  although the inoculation  which
    commenced here in 1721? dripped  that horrid difeafe,
    the fmall-pox, of more than half its terrors, yet it is the.
'   kine-pox that will effect its extermination.  If, there-
    fore, it be found that the latter is every way an  eafier9
    fafer and more pleafant diftemper, and a perfect fecu.
    rity  againft the former, do, not  humanity,  regard to
    our country, the dictates of reafon, and the precepts of
    religion, urge us all to unite our  efforts to exterminate
    64 a difeafe, which has, during the laft  thoufand years,
    deftroyed full a  tenth, and probably a larger  propor-
    tion, of the human race."  To effect fo defirable a
    purpofe, I have laboured to collect, all the evidence on
    this important fubject, and to lay it before the Ameri,
    can public, in fo plain and (imple a manner, as to re-
    quire no other preparation for its admiffion than com-
    mon fenfe and an unprejudiced mind.
                         FINIS, 
[  37   ]
-frojl ■. ,..■,.■»,,
APPENDIX.
          ---------------    IMWII Hill......     -------—


 *TY professional engagements, particularly at
   this season, in the university,  rendered it
   convenient to insert in the news-paper the
   following  general answer  to  a number of
   queries put to me by letter, and otherwise,
   respecting the nature and-inoculation of the
   KINE-POX,


 ift. XVESPECTING its contagion. Iuppears,by
all the obfervations and experiments hitherto made pub-
lic, that the difeafe is not contagious or catching from
one perfon to another.  Even the cows do not take it of
each other, if an open rail-fence be interpofed between
them.   Dr. W's. children labouring under the difor-
der, flept through the whole courfe of it with thofe not
then inoculated  for it.   " It does not feem poffible,
(fays Dr.  Jenner,) for the contagious  matter to pro-
duce the difeafe from effluvia, or by any other means
than conta6t ; fo  that afingle  individual in a family
might at any time receive it without the rifk of infecting
the reft, or of fpreading a difiemper that Jills a country
with terror."

   2d.  Respecting diet previous to receiving the dif-
eafe. Dr. W. had rather inoculate perfons in the pleni- 
r  3«   ]
tude of health, without the  lcaft  alteration of diet, or-
mode of living.

   3d.  It is difficult to anfwer the  queries refpefting
the mildnefs or feverity of the diforder.  Dr. Water-
house  anfwers generally, that in a vaft majority of
cafes, it is incomparably milder than the inoculated
fmall-pox, and it appears from experiments in Eng-
land, that  it has become milder as it  progreffed.  Thus
according to Dr. Woodvill's laft report, out of 310
cafes, only 39 had puftules that fuppurated; viz.  out
of the firfil hundred 19 had puftules ;  out of the y*-
cond 13  ;  and out of the laft 110 only 7  had puftules.
There have been a few cafes,  however,  where it  has
proved an heavy difeafe, the patient being burthened
with between 1000 and 1500 puftules.   It is prefum-
ed, that had fuch perfons been inoculate:1 for the fma]U
pox, they would have died.

   4th.  As to the belt feafon for receiving the difeafe.
In this region,  the feafon preferred  for inoculation
of the kine-pox, as well as the fmall-pox, is from Au-
guft to November ; coolifh nights  and ripe fruit are
pleafant affiftants to the inoculator.   Very cold wea-
ther is  unfavorable to the kine-pox.   It  aggravated
the forenefs of the arm to that degree in England, that
the inoculators were obliged to poftpone their opera-
tions until warmer  weather.   Cold, combined with
dampnefs,  is worft of all.  About a  dozen perfons
palled through the difiemper at Cambridge,, when the
weather was hotter than ever was  known there fince
the afe of thermometers.

   5th. To thofe of the faculty who have  applied to
him by letter tofupply them wtih matter for inoculation^-
he  would juft  obferve, that as he has taken mucl\ 
[  39  ]
pains in this bufinefs, run no fmall rifk of reputation,
as well as of perfonal feelings, there decefew.he trufts,
that will wonder he is anxious to have the matter un-
der his own eye until the practice is more firmly  ef-
tablifhed by the public opinion.   Some unfuccefsful
cafes at the beginning, deprived Scotland of the blef-
fings of inoculation  for the fmall-pox for more than
20 years.  He hopes this idea will operai.,,?^ an ex-
cufe at prefent, even  in the minds o' jffi:i-a&vant
pupils.*                             jf^

    Dr. Wateriiouse* informs thofe wh> ffflv applied
to  him out of Cambridge, to inoculate their families,
that he declined it  only until the diforder had gone
fairly through his own family, and until fome of them
had been inoculated by  Dr. Asp in wall, and  other-
wife expofed to the fmall-pox.   But  having now con-
firmed his affertion, that the kine-pox proteds the eon*
Jtitution from the infedion of the fmall-pox, by a  fair ex-
periment, he is ready to attend  them whenever they
choofe.   Thofe who live in Bofton,  may reft affined,
that from the proximity of his refidence to the capi-
 tal, he fhall make fuch arrangements as to be able to
attend them as punctually as if he refided there.
    Cambridge,  Aug. 10, 1800.

   * Dr. W is happy to find that every gentleman of the fa-
culty in Bofton and its vicinity,  has underltood this, and con-
dueled accordingly. 
L   40   ]
                    POSTSCRIPT.

   ALTHOUGH I am convinc: 1 that the kine-pox is a fhori-
er, fafer, and jpleaiimter difea'e than the  inoculated lma'1-pox even.
when rondutted in  the moft fortunate manner, yet there  is lorne
d  ,'Sey 'JgJ^'-i'^ concG.viiig too lightly of  it.   Tlu  inoculation
of'hjjj^^giiV/ and fixty" perfons  of diffiro.it a<^ ;  and  habu-
hasll^;. W^\th
°f ^,aJ''%k «■ •  "'e11 as attention on that of the p
1 £i" C I, fllB^l.^Bl. .'inefi finininn  tint on nkftGinr
at the kivE-?ox requires fome ca c on the part ^l
 veil as attention on that of the piivf ~bn ; a;..!-**
  &' c ''^KmR/' ~u^ opinion, that an abfthiance fro.n ai.in.al
 food .-.i'^^P^r^G.nulaUng drinks, is js necelfary in the inocula-
 tion of v., '   .;- k as in that of the sma.li.-pox.  A few examples
 will illuftri.e What I wifh to convey.  Two  young  gentlemen
 were rendered fome what uncomfortable for three or four days in cpn-
 fequence of eating anddrinking as ufual.  One, the lea ft attentive
 to diiGtions. after walking to, and from Bofton in a very hot
 day, had his icbiile iymptbms very much aggravated.   His head-
ache was excrucntmg, and a flight delirium came on in tL'e even-
ing, with a it nature ;k.o:s tl*e region or tne f.omacli, vquilto what
we fometimes find in the cafual Imall-pox.  Such inr : ud:at conduft
might have deftn.yed him if inoculated for the Jh»*44-p««^  A l-try,
after eating green-corn, was crammed with fruit, under the abiird
idea that ripe fruit  can hurt no one, fo  that  with  inc
fymptoms of kine-pox was joined a  ciioi.lra morbus.   Ina- ;
nether boy,tbc.MnM?sappearedabout. the 4th day, and arreftedthe'
infection. I could add fome other inftances to prove that this now
uuGGe, mild, and iafe as it is, require/ more  of the phyfician thanf
meiv.lv putting the matter i'ltothe^nn ; but as this '1 *;ri.e i*> ad-.^'
dreuednot lb much to the phys,,4|*anj as to  the common sensb
Ox all, I p npofelv avoid profe/lional directions or criticihi.s.
                    ERRATUM.
Jnfevc:-! place! to.' -( pustles," read " tustules.'* .
 
 
 
M»4,-Hist.

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