UNITED STATES OF AMERICA M^ WASHINGTON, D. C, GPO 16—67244-1 '^yi&^/y-v r -$ '?:""'. :^'~ ;>'• .. < «vi\% * >N _ •* • \ \ \ x ^ \VvV -I &; :J■■{ ♦4 *»>*' v- *• vr CVrc (,-:AiV^ L # t * mniDamaj aswrcHaaiBi AND ' OBSERVATIONS, UPON X THE DISEASES OF THE MIND •, BY BENJAMIN JEtUSH, M. D. Professor \f the Institutes and Practice of Medicine, and of Clinical Practice, in the University 0f Pennsylvania. SECOND EDITION. &• PHILADELPHIA. ,v t. PUBLISHED BY JOHN RICHARDSON, NO. 31, MARKET STREET. 1818. {\/0/V3 • District of Pennsylvania, to tvit: . * BE IT REMEMBERED, that on the twenty-sixth day of October, in the thirty-seventh year of Independence of the United States of America, A. D. 1812, Kimber and Richard- son, of the said District, have deposited in this office, the title of a book, the right whereof they claim as proprietors in the words following, to wit: " Medical Inquiries and Observations, ufion the Diseases of " the Mind. By Benjamin Rush, M. D. Professor " of the Institutes and Practice of Medicine, and of Cli- " nical Practice, in the University of Pennsylvania" In conformity to the act of the Congress of the United States, entitled," An act for the encouragement of learning, by secu- ring the copies of maps, charts, and books, to the authors and proprietors of such copies, during the times therein mention- ed." And also to the act, entitled, " An act supplementary to an act, entitled, u An act for the encouragement of learning, by securing the copies of maps, charts, and books, to the au- thors and proprietors of such copies, during the times there- in mentioned," and extending the benefits thereof to the arts of designing, engraving, and etching historical and other prims." ^ D. CALDWELL, Clerk of the District of Pennsylvania % 1 PREFACE. AGREEABLY to a promise made to the pub- lic some years ago, and in compliance with the so- licitations of the author's pupils, he now offers to them a volume of Medical Inquiries and Observa- tions, upon the Diseases of the Mind. The views which he has taken of the proximate cause, forms, and symptoms of those diseases, have obliged him to employ a new nomenclature to designate some of them. This becomes no less necessary where new opinions are proposed, or new symptoms described in the history of dis- eases, than an increase in the number of words, and new combinations of them, become necessary to accompany the increase of the wants and ob- jects of civilized society. Some of the facts contained in the followino pages are of an old date, and will be familiar to the medical reader, but the republication of them it is hoped will be excused, when it is perceived' that they are placed under the direction of new principles, and that new inferences of a practical nature are deduced from them. An apology may seem necessary likewise for the large number of VI PREFACE. recent facts that have been added to them. Upon subjects so interesting as the present, more than common testimony is necessary to produce con- viction. Besides, facts, or precedents, have the same effects in reasoning in medicine, that exam- ples have in morals. They compel the reader to admit the practice they are intended to establish, provided they are applied in a proper manner. The author has omitted referring to the books from which he has obtained some of his facts. His reason for doing so was, when he began to collect them, he did not expect to publish them, and of course did not mark the volumes and pages from which they were extracted. Since he formed that design, he has faithfully preserved references to them both. He has suppressed them, only be- cause their partial publication would have destroy- ed the uniformity of the work. He commits his imperfect labours, now before the reader, to his fellow citizens, with a hope that they may serve as a supplement to materials already collected, from which a system of principles may be formed that shall lead to general success in the treatment of the diseases of the mind. Experience has ex- hausted herself in abortive efforts for that purpose, and should the following attempt to co-operate with her by principles be alike unsuccessful, it must be ascribed to their being erroneous, for the author believes those diseases can be brought un- der the dominion of medicine, only by just theo- ries of their seats and proximate cause. BENJAMIN RUSH, Philadelphia, October 1812. CONTENTS. CHAPTER I. Page Of the Faculties and Operations of the Mind, and on the Proximate Cause of Intellectual Derange- ment --_-.-_. g CHAPTER II. Of its Remote, Exciting, and Predisposing Causes - 30 CHAPTER III. Of Partial Intellectual Derangement, and particularly of Hypochondriasis, or Tristimania - - - 74 Of the Remedies for Hypochondriasis or Tristimania 98 CHAPTER IV. Of Amenomania, or Partial Intellectual Derangement accompanied with Pleasure, or not accompanied with Distress -......135 CHAPTER V. Of General Intellectual Derangement - - 141 Of the Symptoms of Mania - - - - - 142 Of the different Forms of Mania - - - - 162 Of the Influence of the Moon on Mania - - - 170 CHAPTER VI. Of the Remedies for Mania.....174 CHAPTER VII. OfManicula.......„14 CHAPTER VIII. OfManalgia...... . 216 Of the Remedies for Manalgia - - - - 221 Of the Means of Improving the Condition of Mad People - - - -- - . . 241 Signs of a Favourable and Unfavourable Issue of all the Forms of Intellectual Derangement - 248 viii CONTENTS. Usual Modes of Death from them - 256 CHAPTER IX. Of Demence,or Dissociation - 259 CHAPTER X. Of Derangement in the Will - - - - 263 5 CHAPTER XI. Of Derangement in the Principle of Faith, or the Be- lieving Faculty. - - - - - ~ 2^* CHAPTER XII. Of Derangement of the Memory. - - - 276 Of the Remedies for it......283 CHAPTER XIII. Of Fatuity;.......291 CHAPTER XIV. Of Dreaming, Incubus, or Night Mare, and Somnam- bulism. - ......300 CHAPTER XV. Of Illusions........306 CHAPTER XVI. Of Reverie, or Absence of Mind. - - - - 310 CHAPTER XVII. Of Derangement of the Passions. - - - - 314 Of Love.......- - ibid OfGrief.........318 OfFear.........324 Of Anger. - ' - - - - - - - 333 Of the Morbid Effects of Envy, Malice, and Hatred. 340 Of the torpor of the Passions. .... 345 CHAPTER XVIII. Of the Morbid State of the Sexual Appetite. - - 347 CHAPTER XIX. Of the Derangement of the Moral Faculties. - 357 MEDICAL INQUIRIES AND OBSERVATIONS, ON THE DISEASES OF THE MIND. CHAPTER I. Of the Faculties and operations of the Mind, and on the Proximate Cause and Seat of Intel- lectual Derangement. J.N entering upon the subject of the following Inquiries and Observations, I feel as if I were about to tread upon consecrated ground* I am aware of its difficulty and importance, and I thus humbly implore that being, whose government extends to the thoughts of all his creatures, so to direct mine, in this arduous undertaking, that nothing hurtful to my fellow citizens may fall from my pen, and that this work may be the means of lessening a portion of some of the greatest evils of human life. B 10 ON THE DISEASES Before I proceed to consider the diseases of the mind, I shall briefly mention its different faculties and operations. Its faculties are, understanding, memory, imagi- nation, passions, the principle of faith, will, the moral faculty, conscience, and the sense of Deity. Its principal operations, after sensation, are per- ception, association, judgment, reasoning and vo- lition. All its subordinate operations, which are known by the names ol attention, reflection, con- templation, wit, consciousness, and the like, are nothing but modifications of the five principal ope- rations that have been mentioned. The faculties of the mind have been called, very happily, internal senses. They resemble the ex- ternal senses in being innate, and depending wholly upon bodily impressions to produce their specific operations. These impressions are made through the medium of the external senses. As well might we attempt to excite thought in a piece of marble by striking it with our hand, as expect to produce a single operation of the mind in a person deprived of the external senses of touch, seeing, hearing, taste, and smell. OF THE MIND. 11 All the operations in the mind are the^ effects of motions previously excited in the brain, and every idea and thought appears to depend upon a motion peculiar to itself. In a sound state of the mind these motions are regular and succeed impressions upon the brain with the same certainty and uni- formity that perceptions succeed impressions upon the senses in their sound state. In inquiring into the causes of the diseases of the mind, and the remedies that are proper to re- lieve them, I shall employ the term derangement to signify the diseases of all the faculties of the mind. As the understanding occupies the highest rank of those faculties, and as it is most frequently the seat of derangement, I shall begin by considering the causes, and all the states and forms of its diseases. By derangement in the understanding I mean every departure of the mind in its perceptions, judgments, and reasonings, from its natural and habitual order, accompanied with corresponding actions. It differs from delirium, whether acute, or chronic, in being accompanied with a departure from habitual order, in incoherent conduct, as well 12 ON THE DISEASES as conversation. The latter however is not ne- cessary to constitute intellectual madness, for we sometimes meet with the most incongruous actions without incoherent speech, and we now and then meet with incoherent speech in mad people, in whom the disease does not destroy their habits of regular conduct. This is evinced by the correct- ness with which they sometimes perform certain mechanical and menial pieces of business. Mad- ness is to delirium what walking in sleep is to dreaming. It is delirium, heightened and pro- tracted by a more active and permanent stimulus upon the brain.* Let it not be supposed that intellectual derange- ment always affects the understanding exclusively in the manner that has been mentioned. Far from it. Two or more of the faculties are generally brought into sympathy with it. and there are cases in which all the faculties are sometimes deranged in succession, and rotation, and now and then they are all affected at the same time. This occurs most frequently in the beginning of a paroxysm of * The reader will find several other distinguishing marks between madness and delirium, applicable to legal purposes, in the authors's Introductory Lecture upon Medical Jurispru- dence, published in a volume of Lectures, by Bradford and Inskeep, in the year 1810. OF THE MIND. 13 intellectual madness, but it rarely continues to af- fect the other faculties of the mind after two or three weeks, or after the liberal use of depleting remedies. Thus fever in its first attack, affects the bowels and nervous system, and in a few days settles don'into a disease chiefly of the blood- vessels. Derangement in the understanding has been divided into partial and genaral. The causes of both are the same. I should proceed immediate- ly to enumerate them, but as the seat, or proximate cause, of a disease is generally the first object of a physician's inquiry on entering a sick room, it shall be the first subject of our consideration in the present inquiry. I. The most ancient opinion of the proximate cause of intellectual derangement, or what has been called madness is that it is derived from a morbid state of the liver, and that it discovers it- self in a vitiated state of the bile. Hippocrates laid the foundation of this error by his encomium upon Democritus whom he found employed in examining the liver of a dumb animal in order to discover the cause of madness. 14 ON THE DISEASES 2. Madness has been said to be the effect of a disease in the spleen. This viscus is sup- posed to be affected in a peculiar manner in that grade of madrtess which has been called hyp- pochondriasis. For many years it was known in England by no other name than the spleen, and even to this day, persons who are affected with it are said to be spleeny, in some parts of the New England states. 3. A late French writer, Dr. Prost, in an ingenious work entitled *' Medicine Eclairee par Observation et l'Overture des Corps," has taken pains to prove that madness is the effect of a disease in the intestines, and particularly of their peritoneal coat. The marks of inflamma- tion* which appear in the bowels, in persons who have died of madness, have no doubt favoured this opinion ; but these morbid appearances as well as all those which are often met with in the liver, spleen, and occasionally in the stomach in persons who have died of madness, are the effects, and not the causes of the disease. They are induced cither, 1, by the violent or protracted exercises of the mind attracting orabsorbing the excite- ment of those viscera, and thereby leaving them in that debilitated state which naturally dis- poses them to inflammation and obstruction, OF THE MIND. IS Thus diseases in the stomach induces torpor and costiveness in the alimentary canal. Thus too local inflammation often induces coldness and in- sensibility in contiguous parts of the body. Or, 2, they are induced by the reaction of the mind from the impressions which produce mad- ness, being of such a nature as to throw its mor- bid excitement upon those viscera with so much force as to produce inflammation and obstructions in them. That they are induced by one, or by both these causes, I infer from the increased se- cretion and even discharge of bile which succeed a paroxysm of anger; from the pain in the left side, or spleen, which succeeds a paroxysm of malice or revenge ; and from the pain, and other signs of disease in the bowels and stomach which follow the chronic operations of fear and grief. That the disease and disorders of all the viscera that have been mentioned, are the effects, and not the causes of madness, I infer further from their existing for weeks, months and years in countries subject to intermitting fevers, without producing madness, or even the least alienation of mind. 4. Madness it has been said, is the effect of a disease in the nerves. Of this, dissections af- ford us no proofs; on the contrary, they generally 16 ON THE DISEASES exhibit the nerves after death from madness in a sound state. I object further, to this opinion, that hysteria, which is universally admitted to be seated chiefly in the nerves and muscles, often continues for years, and sometimes during a long life, with- out inducing madness, or if the mind be alienated for a few minutes in one of its paroxysms, it is only from its bringing the vascular system into sympathy, in which I shall say presently thfj cause of madness is primarily seated. The reaction of the mind from the impressions which produce hyste- ria, discovers itself in the bowels, in the kidneys, and in most of the muscular parts of the body. 5. and lastly. Madness has been placed exclu- sively in the mind. I object to this opinion, 1, be- cause the mind is incapable of any operations in- dependently of impressions communicated to it through the medium of the body. 2, Because there are but two instances upon record of the brain being found free from morbid appearances in per- sons who have died of madness. One of these instances is related by Dr. Stark, the other by Dr. De Haen. They probably arose from the brain being diseased beyond that grade in which inflam- mation and its usual consequences take place. Did cases of madness reside exclusively in the mind, a sound state of the brain ought to occur after nearly every death from that disease. OF THE MIND. 17 I object to it, 3, because there are no instances ©f primary affections of the mind, such as grief, love, anger, or despair, producing madness un- til they had induced some obvious changes in the body, such as wakefulness, a full or frequent pulse, costiveness, a dry skin, and other symp- toms of bodily indisposition. I know it has been said in favour of madness being an ideal disease, or being seated primarily in the mind, that sudden impressions from fear terror, and even ridicule have sometimes cured it. This is true, but they produce their effects only by the healthy actions they induce in the brain. We see several other diseases, particularly hiccup, head-ach, and even fits of epilepsy, which are evidently affections of the body, cured in the same way by impressions of fear and terror upon the mind. Having rejected the abdominal viscera, the nerves, and the mind, as the primary seats of mad- ness, I shall now deliver an opinion, which I have long believed and taught in my lectures, and that is, that the cause of madness is seated primarily in the blood-vessels of the brain, and that it depends upon the same kind of morbid and irregular ac- tions that constitute other arterial diseases, There c 18 ON THE DISEASES is nothing specific in these actions. They are a part of the unity of disease, particularly of fever ; of which madness is a chronic form, affecting that part of the brain which is the seat of the mind. My reasons for believing the cause of madness to be seated in the blood-vessels of the brain are drawn, I. From its remote and exciting causes, many of which are the same with tho.^e which induce fever and certain diseases of the brain, particularly phre- nitis, apoplexy, palsy, and epilepsy, all of which Bradmitted to have their seats in a greater or less degree in the blood-vessels. Of thirty-six dissec- tions of the brains of persons who had died of madness, Mr. Pinel says he could perceive no difference between the morbid appearances in them, and in the brains of persons who had died of apoplexy and epilepsy. The sameness of these appearances however do not prove that all those diseases occupy the same parts of the brain : I be- lieve they do not, especially in their first stage : they become diffused over the whole brain, proba- bly in their last stages, or in the paroxysm of death. Dr. Johnson, of Exeter, in speaking of the diseases of the abdominal viscera, mentions their OF THE MIND. 19 sympathy with each other, by what he very hap- pily calls "an intercommunion of sensation." It would seem as if a similar intercommunion took place between all the diseases of the brain. It is remarkable they all discover, in every part of the brain, marks of a morbid state of the blood-ves- sels. II. From the ages and constitutions of persons who are most subject to madness. The former are in those years in which acute and inflam- matory arterial diseases usually affect the body, and the latter, in persons who labour under the arterial predisposition. III. I infer that madness is seated in the blood vessels, 1. From its symptoms. These are a sense of fulness, and sometimes pain in the head ; wake- fulness, and a redness of the eyes, such as precede fever, a whitish tongue, a dry or moist skin, high coloured urine, a frequent, full, or tense pulse, or a pulse morbidly slow or natural as to frequency. These states of the pulse occur uniformly in re- cent madness, and one of them, that is frequency, is seldom absent in its chronic state. 20 ON THE DISEASES I have taken notice of the presence of this symptom in my Introductory Lecture upon the Study of Medical Jurisprudence, in which I have mentioned, that seven-eighths of all the deranged patients in the Pennsylvania Hospital in the year 1811 had frequent pulses,* and that a pardon was granted to a criminal by the president of the United States, in the year 1794, who was suspected of counterfeiting madness, in consequence of its hav- ing been declared by three physicians that that symptom constituted an unequivocal mark of in- tellectual derangement. The connection of this disease with the state of the pulse has been further demonstrated by a most satisfactory experiment, made by Dr. Coxe, and related by him in his Practical Observations upon Insanity. He gave digitalis to a patient who was in a furious state of madness, with a pulse that beat*90 atrokes in a minute. As soon * This fact was ascertained, at my request, with great accu- racy, by Dr. Frederick Vandyke. It is probable the pulsa- tions of the arteries in the brain were preternaturally frequent in the brain in the few cases in which they were natural at the wrists. Dr. Cox, of Bristol, informs us that he had found the carotid artery to be full and tense, when the radial artery was weak and soft. OF THE MIND. 21 as the medicine reduced his pulse to 70, he be- came rational. Upon continuing it, his pulse fell to 50, at which time he became melancholy. An additional quantity of the medicine reduced it to 40 strokes in a minute, which nearly suspended his life. He was finally cured by lessening the doses of the medicine so as to elevate his pulse to 70 strokes in a minute, which was probably its natural state. In short there is not a single symptom that takes place in an ordinary fever except a hot skin, that does not occur in the acute state of madness. IV. From its alternating with several diseases which are evidently seated in the blood-vessels. These are consumption, rheumatism, intermitting and puerperile fever, and dropsy, many instances of which are to be met with in the records of medicine. V. From its blending its symptoms with several of the forms of fever. It is sometimes attended with regular intermissions, and remissions. I have once seen it appear with profuse sweats, such as occur in certain fevers, in a madman in the Pennsylvania Hospital. These sweats, when discharged from his skin, formed a vapour re- sembling a thick fog, that filled the cell in which 22 ON THE DISEASES he was confined to such a degree as to render his body scarcely visible. Again, this disease sometimes appears in a typhus form, i<> which it is attended with cold» ness, a feeble pulse, muttering delirium, and in- voluntary discharge of faeces and urine. But it now and then pervades a whole country in the form of an epidemic. It prevailed in this way in England in the years 1355 and 1373, and in France and Italy in the year 1374, and Dr. Win- tringham mentions its frequent occurrence in England in the year 1719. A striking instance of the union of madness with common fever is mentioned by Lucian. He tells us that a violent fever once broke out at Abdera, which terminated by haemor- rhages, or sweats, en the seventh day. During the continuance of this fever the patients affected with it, repeated passages from the tragedy of Andromeda with great vehemence, both in their sick rooms and in the public streets. This mix- ture of fever and madness continued until the coming on of cold weather. Lucian ingeniously and very properly ascribes it to the persons affect- ed, having heard the famous player A'cs ilaus act a part in the above tragedy in the middle of sum- OF THE MIND. 23 mer, in so impressive a manner that it excited in them the seeds of a dormant fever which blended itself with derangement, and thus produced, v ry naturally, a repetition of the ideas and sounds that excited their disease. VI. From the appearances of the blood which is drawn in this disease being the same as that which is drawn in certain fevers. They are, in- flammatory buff, yellow, serum, and lotura car- mum. VII. From the appearances of the brain after death from madness. These are nearly the same as after death from phrenitis, apoplexy, and other diseases which are admitted to be primary affec- tions of the blood-vessels of the brain. I shall briefly enumerate them ; they are, 1, the absence of every sign of disease. I have ascribed this to that grade of suffocated excitement which pre- vents the effusion of red blood into the serous vessels. We observe the same absence of the marks of inflammation after several other violent diseases. Dr. Stevens in his ingenious inaugural dissertation published in 1811> has called this appa- rently healthy appearance, the " aimatous" state of inflammation. Perhaps it would be more proper to call it the " aimatous" state of disease. It is 24 ON THE DISEASES possible it may arise in recent cases of madness which terminate fatally, from the same retrocession of the blood from the brain which takes place from the face and external surface of the body, just be- fore death. But, 2. We much oftener discover in the brain, after death from madness, inflammation, effusions of water in its ventricles, extravasation and innova- tion of blood, and even pus. After chronic mad- ness, we discover some peculiar appearances which have never been met with in any other disease of the brain, and these are a preternatural hardness, and dryness in all its parts. Lieutaud mentions it often with the epithets of "durum," " praedurum," "siccum," and "exsuccum." Morgagni takes notice of this hardness likewise, and says he had observed it in the cerebrum in persons in whom the cerebellum retained its natu- ral softness. Dr. Bailie and Mr. John Hunter jbave remarked, that the brain in this state discov- ered marks of elasticity when pressed by the fin- gers. Mr. Mickell says a cube of six lines of the brain of a maniac, thus indurated, weighed seven drams, whereas a cube of the same dimen- sion of a sound brain weighed but one dram, and between four and six grains. I have ascribed this hardness, dryness, elasticity and relative weight of OF THE MIND. 25 the brain to a tendency to schirrus, such a-suc- ceeds morbid action or inflammation in glandular parts of the body, and particularly that early grade of it which occurs in the liver, and which is known by the name of hepitalgia. The brain in this c.se loses its mobility so as to become incapa- ble of emitting those motions from impressions which produce the operations of the mind. 3. We sometimes discover preternatural soft- ness in the brain, in persons who die of madness, similar to that which we find in other viscera from common and febrile diseases. This has been ob- served to occur most frequently in the kidneys and spleen. The brain in this case partakes of its texture and imbecillity in infancy, and hence its inability to receive and modify the impressions which excite thought in the mind. 4. and lastly. We sometimes discover a pre- ternatural enlargement of the bones of the head from madness, and sometimes a preternatural re- duction of their thickness. Of 216 maniacs whose heads were examined after death, Dr. Creighton says in 160 the skull was enlarged, and in 38 it was reduced in its thickness. Now the same thing succeeds rheumatism, and many D 26 ON THE D 1SE ASES othef febrile diseases which exert their action m the neighbourhood of bones. I might add further, under this head, that the morbid appearances in the spleen, liver, and sto- mach, which are seen after death from madness, place it still more upon a footing with fevers from all its cas es, and particularly from koino-mias- matic exhalations, and in a more especial manner when they affect the brain, and thereby induce primary, or idiopathic phrenitis. In short mad- ness is to phrentis, What pulmonary consumption is to pneumony, that is a chronic state of an acute disease. It resembles pulmonary consumption further, in the excitement of the muscles, and in the appetite continuing in a natural, or in a pre- ternatural state. VIII. I infer madness to be primarily seated in the blood-vessels, from the remedies which most speedily and certainly cure it, being exactly the same as those which cure fever or disease in the blood-vessels from other causes, and in other parts of the body. They will be noticed in their proper place. I have thus mentioned the facts and arguments which prove what is commonly called madness to OF THE MIND. 27 be a disease of the blood-vessels of the brain. All the other and inferior forms of derangement, whether of the memory, the will, the principle of faith, the passions, and the moral faculties, I be- lieve to be connected more or less with morbid action in the blood-vessels of the brain, or heart, according to the seats of those faculties of the mind. In placing the primary seat of madness in the blood-vessels, I would by no means confine the predisposition to it exclusively to them. It ex- tends to the nerves, and to that part of the brain which is the seat of the mind, both of which when preternaturally irritable, communicate more promptly, deranged action to the blood-vessels of the brain. I have called the union of this diffu- sed morbid irritability, the phrenitic predisposi- tion. It is from the constant presence of this pre- disposition, that some people are seldom affected with the slightest fever, without becoming deli- rious ; and it is from its absence, that many people are affected with fevers and other diseases of the brain, without being affected with derangement. I am aware that it may be objected to the proxi- mate cause or seat of madness, which has been delivered, that dissections have sometimes discov- ered marks of arterial diseases in the brain similar 28 ON THE DISEASES to those that have been mentioned, which were not preceded by the least alienation of mind. In these cases, I would supp se the diseases may have existed in parts of the brain which are not occupied by the mind, or that the mind may have been translated to ancther, and a healthy part of the brain. The senses of taste and hear- ir.g, we know, when impaired by disease, are often translated to contiguous, and sometimes to remote parts of t! e body. But did we admit the objec- tion that 1 have met, to militate against madness being an arterial disease, it would prove too much, for we sometimes discover the same morbid ap- pearances, which produce apoplexy and palsy, to be present in the brain after death, without any of the common symptoms of those diseases having been preceded by them. Many other organic diseases are occasionally devoid of their usual characteristic symptoms. Neither vomiting, nor want of appetite, have taken place in stomachs in which mortification has been discovered after death ; and abscesses have been found in the livers of persons, who have died without any one of the common symp- toms of hepatitis. By allowing the same latitude to the " confused and irregular operations of na- OF THE MIND. 29 ture," in the brain, in the production of madness, that we observe in the production of all the other diseases that have been mentioned, we can recon- cile its occasional absence, with the existence of all the organic affections in the brain which usual- ly produce it. In reviewing the numerous proofs of madness, being seated primarily in the blood-vessels, and its being accompanied so generally with most of the symptoms of fever, we cannot help being struck with the histories of the disease that have been given by many ancient and modern physi- cians. Galen, defines it to be "delirium sine ebre." Aritaeus says it is "semper sine febre." Dr. Arnold quotes a group of authors, who have adopted and propagated the same error. Even Dr. Heberden admits and reasons upon it. The antiquity and extent of this error should lead us never to lose sight of the blood-vessels in investi- gating the causes of diseases. They are, to a physician, what the meridian sun is to a mariner. There are but few diseases in which it will be possible for him to preserve the system in a heal- thy course, without daily, and often more frequent observations of the state of the blood-vessels, as manifested by the different and varying states of the pulse. CHAPTER II. OF the remote and exciting causes of intellectual derangement. I have combined both these classes of. causes, inasmuch as they most commonly act in concert, or in a natural succession to each other. In enu- merating them, I shall include such as act alike in producing partial and universal madness. They have been divided, 1, into such as act, directly upon the body ; and, 2, such as act indi- rectly upon the body, through the medium of the mind. To the first head belongs, 1, all those causes which act directly upon the brain. These are, 1, malconformation and laesions of the brain. Be- tween the latter, and the existence of madness, there is sometimes an interval of several years, A young man died in the Pennsylvania Hospital in the year 18p9, who became deranged at twenty- OF THE MIND. 31 one, in consequence of a contusion on his head by a fall from a horse in the fifteenth year of his age. A Mr. ----died of madness in the same place, from an injury done to his brain by being thrown out of his chair, between two and three years before he discovered any signs of derangement. It is remarkable that injuries show themselves more slowly in the brain than in other parts of the body. Dr. Lettsom men- tions a case, in the Memoirs of the London Medi- cal Society, of a disease in the brain, induced by a fall from a horse, which did not discover itself until two and twenty years after its occurrence. 2. Certain local disorders, induced by enlarge- ment of the bone, tumors, abscesses, and water in the brain. 3. Certain diseases of the brain, particularly apoplexy, palsy, epilepsy, vertigo, and head- ach. It occurs but rarely from the last of those causes. 4. Insolation. Two cases of madness from this cause occurred under my care between July 1807, and February lb08. 5. Certain odours. There is a place in Scot- land where madness is sometimes induced by 32 ON THE DISEASES the fumes of lead. Patients who are affected with it bite their hands, and tear their flesh upon the other parts of their bodies. It is called by the country people mill-reck. Dr. Prost describes a furious grade of madness in Peru, brought on by a mineral exhalation ,but he does not mention the metal from which it is derived. From among many other facts that might be mentioned, to show the connection of odours with a morbid state of the mind, I shall mention one more. An ingenious dyer, in this city, informed me that he often observed the men who were employed in dying blue, of which colour indigo is the basis, to become peevish, and low spirited, and never even to hum a tune, while engaged at their work. There are certain causes which induce mad- ness, by acting upon the brain in common with the whole body. These are, 1, gout, drops consumption, pregnancy, and fevers of all kinds. 2. Inanition from profuse evacuation, or from a defect of nourishment. Famine induces it in part from the latter cause. 3. The sudden abstraction of the stimulus of distension. When madness follows parturi- OF THE MIND. 33 tion, it is most commonly derived from this cause. . 4. The excessive use of ardent spirits. During the time Dr. Nicholas Waters acted as resident physician and apothecary of the Pennsylvania Hos- pital, he instituted an inquiry at my request, into the proportion of maniacs from this cause, who were confined in the Hospital. They amounted to one third of the whole number. 5. Inordinate sexual desires and gratifications. Several cases of madness from this cause have come under my notice. 6. Onanism. Four cases of madness occurred, in my practice, from this cause, between the years 1804 and 1807. It is induced more frequently by this cause in young men, than is commonly supposed by parents and physicians. The mor- bid effects of intemperance in a sexual intercourse with women are feeble, and of a transient nature, compared with the train of physical and moral evils which this solitary vice fixes upon the body and mind. 7. The transfusion of blood from one animal into the blood-vessels of another. This practice E 34 ON THE DISEASES was employed in France many years ago, in order to discover a method of restoring health, and re- novating life, in sick and aged people. All the persons, Dionis tells us, who were the subjects of it, died in a state of derangement. The practice was founded in error; for old age and sickness are occasioned by exhausted or diseased solids, and not by any unfitness in the quality of the blood, to support animal life. 8. Great pain. 9. Unusual labour or exercise. 10. Extremely hot and cold weather. 3. Madness is induced by corporeal causes, which act sympathetically upon the brain. These are, 1, certain narcotic substances, particularly opium, hemlock, night-shade, hen-bane, and ac- conitum, taken into the stomach. 2. The suppression of any usual evacuation, such as the menses, lochia, milk, semen, or blood from the haemorrhoidal vessels. 3. Worms in the alimentary canal. OF THE MIND. 35 4. Irritation from certain foreign matters re- tained in irritable parts of the body. I once knew some small shot which were lodged in the foot of a school boy, induce madness several years after he became a man. It has been brought on in one instance by decayed teeth, which were not accom- panied with pain. 4. Madness is sometimes induced by what is called a m tastasis of some other disease to the brain. These diseases are, 1, dropsy. A case of madness from this cause is related by Dr. Mead. 2. Consumption. All the symptoms of this disease sometimes suddenly disappear, in con- sequence of the translation of morbid excitement to the brain. 3. St. Vitus's dance. I attended a young lady some years ago, in whom this disease was sus- pended by an attack of madness. Her madness passed out of her brain, through the same channel by which it entered it, that is, in convulsions in the limbs of one side, which gradually yielded to the power of medicine. 4. Hysteria. The morbid commotions in the nervous system are sometimes transferred to the 36 ON THE DISEASES blood-vessels, and the brain, where they induce transient or chronic madness. 5. Certain cutaneous eruptions. The son of Dr. Zimmerman became deranged in conse- quence of an eruption being repelled from his skin. I attended a private patient in the Penn- sylvania Hospital, in whom madness was induced by the same cause. The healing of an old and habitual ulcer, has sometimes produced the same effect. 6. The measles. A young man, of sixteen years of age was admitted into the Pennsylva- nia Hospital, in June 1812 in a high state of de- rangement, which followed this disease. II. The causes which induce intellectual de- rangement, by acting upon the body through the medium of the mind, are of a direct and indirect nature. The causes which act directly upon the under- standing are. 1. Intense study, whether of the sciences or of the mechanical arts, and whether of real or imagi- nary objects of knowledge. The latter more fre- OF THE MIND. 37 quently produce madness than the former. They are, chiefly, the means of discovering perpetual motion ; of converting the base metals into gold, of prolonging life to the antediluvian age ; of pro- ducing perfect order and happiness in morals and government, by the operations of human reason ; and, lastly, researches into the meaning of certain prophesies in the Old and New Testaments. I think I have observed madness from the last cause, to arise most frequently from an attempt to fix the precise time in which those prophe- sies were to be fulfiled, or from a disappointment in that time, after it had passed. 2. The frequent and rapid transition of the mind from one subject to another. It is said booksellers have sometimes become deranged from this cause. The debilitating effects of these sudden transitions upon the mind, are sensibly felt after reading a volume of reviews or maga- zines. The brain in these cases is deprived of the benefit of habit, which prevents fatigue to a certain extent, from all the exercises of the body and mind, when they are confined to single ob- jects. It is worthy of notice that this cause of madness accords exactly with a symptom of one of its 38 OF THE DISEASES forms, and that is, a constant and rapid transition of tile mind to a variety of unrelated subjects. But the understanding is affected chiefly in an in- direct manner. 1. Through the medium of the imagination. It is conveyed into the understanding from this faculty, in all those people who became deranged from inordinate Aschemes of ambition or avarice. Mad-houses, in every part of the world, exhibit instances of persons who have become insane from this cause. The great extent and constant exer- cises of the imagination in poets, accounts for their being occasionally affected with this disease, 2. The understanding is sometimes affected with madness through the medium of the memo- ry. Dr. Zimmerman relates the case of a Swiss clergyman, in whom derangement was induced by undue labour in committing his sermons to memory. 3. But madness is excited in the understanding most frequently by impressions that act primarily upon the heart. I shall enumerate some of these impressions, and afterwards mention such instan- ces of their morbid effects as I have met with in the course of my reading and observations. OF THE MIND. 39 They are joy, terror, love, fear, grief, distress, shame from offended delicacy, defamation, ca- lumny, ridicule, absence from native country, the loss of liberty, property, and beauty, gaming, and inordinate love of praise, domestic tyranny, and, lastly, the complete gratification of every wish of the heart. Extravagant joy produced madness in many of the successful adventurers in the South-Sea specu- lation in England, in the year 1720. Charles the Sixth, of France, was deranged from a paroxysm of anger. Terror has often induced madness in persons who have escaped from fire, earthquakes, and shipwreck Two cases from the last cause have occurred under my notice, Where is the mad-house that does not con- tain patients from neglected, or disappointed love? Fear often produces madness, Dr. Brambilla tells us, in new recruits in the Austrian army. 40 ON THE DISEASES Grief induced madness which continued fifty years, in a certain Hannah Lewis, formerly a pa- tient in the Pennsylvania Hospital. Distress often produced this disease, Mr. How- ard tells us in the prisoners of the town of Leige. An exquisite sense of delicacy, Dr. Burton says, produced madness in a school-master, who was accidentally discovered upon a close-stool by one of his scholars. The Bedlams of Europe exhibit many cases of madness from public and private defamation, and history informs us of ministers of state and o-enerals of armies having often languished away their lives in a state of partial derangement, in consequence of being unjustly dissmised by their sovereigns. A player destroyed himself in Philadelphia, in the year 1803, soon after being hissed off the stage. The Swiss soldiers sometimes languish and die from that form of madness which is brought on by absence from their native country. OF THE MIND. 41 An ingenious modern poet mentions this dis- ease, as well as its exciting cause, with peculiar elegance. l< The intrepid Swiss that guards a foreign shore, " Condemn'd to climb his mountain-cliffs no more, " If chance he hear the song, so sweetly wild, " Which, on those cliffs, his infant hours beguil'd, " Melts at the long lost scenes, that round him rise, " And sinks a martyr to repentant sighs." It is remarkable, this disease is most com- monly among the natives of countries that are the least desirable for beauty, fertility, climate, or the luxuries of life. They resemble in this respect, in their influence upon the human heart, the artificial objects of taste which are at first disagreeable, but which from habit take a stron- ger hold upon the appetite than such as are natural and agreeable. The Africans become insane, we are told, in some instances, soon after they enter upon the toils of perpetual slavery in the West Indies. Hundreds have become insane in consequence of unexpected losses of money. It is remarka* ble this disease occurs oftener among the rich who lose only a part of their property, than F / 42 ON THE DISEASES among persons in moderate circumstances, who lose their all. An American Indian became deranged, and destroyed himself, in consequence of seeing his face in a looking glass soon after his recovery from a violent attack of the small-pox. The loss of one eye, by an affray in a country tavern, which materially affected the beauty of the face, produced derangement in a young man who was afterwards my patient in the Pennsylvania Hospital. There are other facts, which show the depth of this attachment to beauty in the human mind, and the poignancy of the dis- tress occasioned by its loss, or decay. The once beautiful lady Mary Wortley Montague tells a friend, in one of her letters, that she had not seen herself in a looking glass for eleven years, solely from her inability to bear the morti- fying contrast between her appearance in the two extremes of her life. A clergyman in Maryland became insane in consequence of having permitted some typo- graphical errors to escape in a sermon which he published upon the death of general Wash^ ington; OF THE MIND. 43 The son of a late celebrated author in England became deranged in consequence of the severe treatment he received from his father in the course of his education. Several instances of madness, induced by the cruel or unjust con- duct of school masters and guardians to the persons who were the subjects of their power and care, are to be met with in the records of medi- cine Sir Philip Mordaunt shot himself immedi- ately after succeeding to a great estate, and to the favour of his prince, and while he appeared to be in possession of every thing that could constitute the plenitude of human happiness. The eldest son of a Scotch nobleman,of high rank and large fortune, destroyed himself in the same way, a few weeks after the consummation of all his worldly prospects and enjoyments by his marriage to a most accomplished and ami- able young lady. Two instances are upon record, of persons who destroyed themselves immediately after drawing high prizes in a lottery. In all these cases death was the effect of derangement. 44 ON THE DISEASES 4. The understanding is sometimes deranged through the medium of the moral faculties. A conscience burdened with guilt, whether real or imaginary, is a frequent cause of madness. The latter produces it much oftener than the former. An instance of insanity occurred in a married woman in this city some years ago, of the most exemplary character, from a belief that she had been unfaithful to the marriage bed. An ac- cident discovered that the supposed criminal connection was with a man whose very person was unknown to her. There is further a mor- bid sensibility in the conscience in some people, that predisposes to madness from the most trifling causes. A young man, of great piety, died of this disease in our Hospital a few years ago, in consequence of his believing that he had offend- ed his Maker by refusing to say grace at the table of a friend. The most distressing grade of derangement under this head is, where real guilt, and a dis- eased imagination concur in producing it. The occasional acts of self-mutilation which deranged patients sometimes inflict upon themselves, and the painful and protracted austerities voluntarily imposed upon the body in Catholic countries. OF THE MIND. 45 appear to be the effects of the combined opera- tion of these two causes upon the understand- ing. But we sometimes observe intellectual derange- ment to occur from the moral faculties being unduly exited by supposed visions and revela- tions, instances of which will be mentioned in another place. Let not religion be blamed for ^hese cases of insanity. The tendency of all its doctrines and precepts is to prevent it from most of its mental causes; and even the errors that have been blend- ed with it produce madness less frequently than love, and many of those common and necessary pursuits, which constitute the principal enjoy- ments and business of life. To the history of the causes of derangement which has been given, I shall add, that that form of it which has been called hypocondriasis, is sometimes induced without either the patient or his friends being able to ascribe it to any cause. Dr. Nicholas Robinson, a physician who lived in the beginning of the last century, complains, in a trea- tise which he has published upon melancholy, of his sufferings from it in the following words : 46 ON THE DISEASES "When no air has blown across my affairs, and no shade obscured my sun, then am I most mis- erable." I have heard similar declarations from several of my patients, and particularly from a clergyman of the most exemplary life and con- versation. In all such cases it would be absurd to suppose the disease existed without a cause. Many diseases take place in the body from causes that are forgotten, or from sympathies with parts of the body that are supposed to be in a healthy state. In like manner, depression of mind may be induced by causes that are forgotten; or by the presence of objects which revive the sensation of distress with which it was at one time associated, but without reviving the cause of it in the me- mory. The former pupils of the author will re- collect several instances of mental pleasure, as well as pain, from association, mentioned by him in his physiological lectures upon the mind, in which the original causes of both had perished in the memory. Intellectual derangement is more common from mental, than corporeal causes. Of 113 patients in the Bicetre Hospital in France, at one time, Mr. Pinel tells us 34 were from domestic misfor- tunes, -24 from disappointments in love, 30 from the distressing events of the French Revolution, OF THE MINB. 47 and 25 from what he calls fanaticism, making in all the original number. I have taken pains to ascertain the proportian of mental and corporeal causes which have operated in producing madness in the Pennsylvania Hospital, but I am sorry to add, my success in this inquiry was less satisfac- tory than I wished. Its causes were concealed in some instances, and forgotten in others. Of fifty maniacs, the causes of whose disease were discovered by Dr. Moore and his assistant Mr. Jenney, in the month of April 1812, 7 were from disappointments, chiefly in love; 7 from grief: 7 from the loss of property; 5 from erroneous opinions in religion ; 2 from jealousy; 1 from terror ; 1 from insolation ; 1 from an injury to the head ; 2 from repelled eruptions; 5 from in- temperence ; 3 from onanism , 2 from pregnancy ; and 1 from fever; making in all 34 from mental, and 16 from corporeal causes. A predisposition to the disease was hereditary in but five of them. I shall now mention all those circumstances in birth, certain peculiarities of the body, age, sex, condition and rank in life, intellect, occu- pation, climate, state of society, forms of go- vernment, revolutions, and religion, which pre- dispose the body and mind to be acted upon by the remote and exciting causes that have 48 ON THE DISEASES been mentioned, so as to favour the production of madness. I. A peculiar and hereditary sameness of or- ganization of the nerves, brain, and blood-ves- sels, on which I said formerly the predisposi- tion to madness depended, sometimes pervades whole families, and renders them liable to this disease fromu transient or feeble operation of its causes. Application was made some years ago for the admission of three members of the same family into the Pennsylvania Hospital on the same day. I have attended two ladies, one of whom was the fourth, and the other the ninth, of their respective families, that had been affected with this disease in two generations. The following letter to the author, from Dr Ste- phen W. Williams, of Deerfield, in Massachu- setts, contains the history of two cases of here- ditary madness, which, from the singular resem- blance in their subjects, symptoms and issue, have seldom perhaps been met with in the records of medicine. OF THE MIND. 49 June 16th, 1812. Dear Sir, " Believing that " the science of medicine is related to every thing," I am induced to trans- mit to you the following incidents which have lately occurred in the vicinity of this place, hoping that some useful inductions may be drawn from them, for the benefit of our profession. " Captains C. L. and J. L. were twin brothers, and so great was the similarity in their counte- nances and appearance, that it was extremely dif- ficult for strangers to know them apart. Even their friends were often deceived by them. Their habits and manners were likewise simi- lar. Many ludicrous stories are told of peo- ple mistaking one for the other. " They both entered the American revolutionary army at the same time. Both held similar com- missions and both served with honour during the war. They were cheerful, sociable, and in every respect gentlemen. They were happy in their families, having amiable wives and children and they were both independent in their proper- ty. Some time after the close of the war, cap- tain J. removed to the state of Vermont, while captain C. remained in Greenfield, in the. vicini- 56 ON THE diseases ty of Deerfield, and 200 miles from his brother. Within the course of three years, they have both been subject to turns of partial derange- ment, but by no means rising into mania, nor sinkings into melancholy. They appeared to be hurried and confused in their manners, but were constantly able to attend to their business. About two years ago, captain J. on his return from the general assembly of Vermont, of which he was a member, was found in his chamber, early in the morning, with his throat cut, by his own hand, from ear to ear, shortly after which he expired. He had been melancholy a few days previous to this fatal catastrophe, and had complained of indisposition the evening previous to the event. " About ten days ago, captain C. of Greenfield, discovered signs of melancholy, and expresed a fear that he should destroy himself. Early in the morning of June fifth he got up, and pro- posed to his wife to take a ride with him. He shaved himself as usual, wiped his razor, and stepped into an adjoining room, as his wife supposed, to put it up. Shortly after she heard a noise, like water or blood running upon the floor. She hurried into the room, but was too ON THE MIND. 51 late to save him. He had cut his throat with his razor, and soon afterwards expired. " The mother of these two gentlemen, an aged lady, and their two sisters, the only survivors of their family, have been subject, for several years, to the same complaint." There are several peculiarities which attend this disease, where the predisposition to it is hereditary, which deserve our notice. 1. It is excited by more feeble causes than in persons in whom this predisposition has been ao- quired. 2. It generally attacks in those stages of life in which it has appeared in the patient's ancestors. A general officer, who served in the American army during the revolutionary war, once express- ed a wish to a brother officer, from whom I re- ceived the information, " that he might not live to be old, that he might die suddenly, and that if he married, he might have no issue." Upon being asked the reason for these wishes, he said, he was descended from a family in which madness had sometimes appeared about the fiftieth year 52 ON THE DISEASES of life, and that he did not wish to incur the chance of inheriting, and propagating it to a fami- ly of children. He was gratified in all his three wishes. He fell in battle between the thirtieth and fonieth years of his age, and he left no issue, although he had been married several years before his death. A similar instance of the disease ap- pearing at the same time of life, in three persons of the same family, occurred under my notice in the Pennsylvania Hospital. It came on in a father and two of his sons between the sixtieth and seventieth years of their lives. 3. Children born previously to the attack of mad- ness in their parents are less liable to inherit it than those who are born after it. 4. Dr. Burton, in his Anatomy of Melancholy, remarks, that children born of parents who are in the decline of ;ife, are more predisposed to one of the forms of partial insanity than children born under contrary circumstances. 5. A predisposition to certain diseases seat- ed in parts contiguous to the seat of madness, often descends from parents to their children. Thus we sometimes see madness in a son whose father or mother had been afflicted only with hys- OF THE MIND. 53 teria, or habitual head-ach. The reverse of this remark likewise sometimes takes place. I at- tended a respectable mechanic in this city in two remarks of madness, the last of which termi* nated his life. All his children, six in number, and now all adults, are afflicted with head ach, but none of them have ever discovered any sign of madness in their conduct or conversation. 6. There are instances of families in which madness has existed, where the disease has pass- ed by the understanding in their posterity, and appeared in great strength and excentricity of the memory and of the passions, or in great per- version of their moral faculties. Sometimes it passes by all the faculties of the mind, and ap- pears only in the nervous system, in persons de- scended from deranged parents, again we see mad- ness in children whose parents were remarkable only for eccentricity of mind. There are several diseases which attack the children of the same family, which did not exist in their ancestors. I have called them filial dis- eases. They are chiefly consumption and epi- lepsy. I have attempted to discover whether madness never appears in this way, and have heard of but two instances of it. One of them occur- 54 ON THE DISEASES red in a family in the island of Barbadoes,in which four children, descended from parents of habitual- ly sound minds, because deranged, Perhaps in tiese cases the disease had existed in their remote ancestors, or possibly it was translated from a dis- ease in some of the contiguous systems of the body. I have wished to discover whether there be any peculiarity of shape in the sculls of mad people that predisposed to derangemnnt, for which purpose I requested Dr. Vandyke, in the year 1810, to examine the dimensions of the heads of all the insane patients in our hospital in several different directions, and afterwards to measure in the same way the heads of a number of patients, belonging to the Hospital, with other diseases. The result of this inquiry was a discovery that there was no departure but in one instance from the ordinary and natural shape of the head, in be- tween sixty and seventy mad people. II. A predisposition to madness is said to be connected with dark coloured hair. Mr. Haslam informs us that this was the case in two hundred and five out of two hundred and sixty-five pa- tients in the Bethlehem Hospital. He intimates that it was possibly from their consisting chiefly of the natives of England, in whom that colour of the hair is very general; but the same connection OF THE MIND. 55 between madness and dark coloured has been discovered in the maniacs in the Pennsylvania Hospital, who consist of persons from three or four different countries, or of descendants who in- herit their various physical characters. Of nearly se- venty patients, who were examined at my request, by Dr. Vandyke, in our Hospital, in the year 1810 with a reference to this fact, all, except one, had dark coloured hair. In the month of April, 1812, I requested Dr. Vandyke to direct his inquiries more particularly to the colour of the eyes in the maniacal patients in our Hospital. He executed my request with great care and correctness, and disco- vered that fifty-six out of seventy-nine of them had light coloured eyes, of which number but six had fair hair. III. There is a greater predisposition to mad- ness between twenty and fifty, than in any of the previous or subsequent years of human life. Of the correctness of this remark, Mr. Pinel has furnished us with the following proof. Of 1201 persons who were admitted into the Bicetre Hos- pital in France, between the years 1784 and 1794, 955 were between the two ages that have been mentioned, 65 were between fifteen and twenty, 131 ""were between fifty and sixty, and 51 between sixty and seventy-one. Mr. 56 5N THE DISEASES Haslam has furnished additional evidence of the correctness of this remark. Of 1664 deranged patients who were admitted into the Bethlehem Hospital in London, between the years 1784 and 1794, he tells us 910 of them were betWeen the ages mentioned by Mr. Pinel. But the propor- tion of maniacal patients, above twenty and under fifty years of age, was much greater in the Penn- sylvania Hospital in the month of April 1812. It was ascertained by Dr. Vandyke to be 68 out of 79, that is nearly seven-eighths of their whole number. From the state of the body and mind within those periods, it is easy to account for this being the case. The blood-vessels and the nerves are then in a highly excitable state, and the former readily assume morbid or inflama- tory action from the remote and exciting causes of disease. The mind too, within those years, possesses more sensibility, and of course is more easily acted upon by mental irritants, the sour- ces of which from family afflictions, and dis- appointments in the pursuits of business, plea- sure and ambition, are more numerous in those years, than in any of the previous or subsequent stages of life. Madness, it has been said, seldom occurs under puberty. To the small number of instances of OF THE MIND. 57 it that are upon record, I shall add four more. Two boys, the one of eleven and the other of seven years of age, were admitted into our Hos- pital with this disease (the latter during the time of my attendance in 1799) and both discharged cured. I have since seen an instance of it in the year 1803, in a child of two years old, that had been affected with cholera infantum ; and another in a child of the same age, in the year 1808, that was affected with internal dropsy of the brain. They both discovered the countenance of madnes, and they both attempted to bite, first their mothers, and afterwards their own flesh. The reason why children and persons under puberty are so rarely affected with madness must be ascribed to men- tal impressions, which are its most frequent cause, being too transient in their effects, from the in- stability of their minds, to excite their brains into permanently diseased actions. It is true, chil- dren are often affected with delirium, but this is a symptom of general fever, which is always in- duced, like the few cases of madness in children that I have mentioned, only by corporeal causes. From the records of the Bicetre Hospital, in France, it appears that madness rarely occurs in old age. Doleus and Dr. Greding mention several cases of it; the latter in a man of eighty- five. 1 have attended two men between sixt: H 58 OrtJ THE DISEASES and seventy, and one woman between seventy and eighty, in the Pennsylvania Hospital, and a private patient in the eighty-first year of his age, in this disease. It has been said that maniacs seldom live to be old. I have known but few exceptions to this remark, and they were of per- sons in whom the extinction of the mind, in idi- otism, had protected the body from being worn out prematurely by its constant and preternatural excitement or depression. One of the persons was Hannah Lewis, formerly mentioned, in whom the disease was induced by grief, in middle life, from the loss of her husband. She died in our Hospital in the year 1799, in the eighty-seventh year of her age. A predisposition to longevity, which she derived from her ancestors, predomi- nated over the tendency of her long protracted disease to destroy her life. She lost one sister in the eighty second year of her age, and at the time of her death had another living who was ninety- four, neither of whom had ever been affected with madnes. There are two reasons why this disease so rarely attacks old people. Their blood- vessels lose their vibratility from age, and hence they are less liable to fevers than in middle life; and from the diminution of sensibility in their nerves and brains, the causes of madness make but a feeble and transient impression upon their minds. In the latter condition of their bodies, OF THE MIND. 59 they revert to that state which takes place in chil- dren, and which I have said protects them from the frequent occurrence of this disease. V. Women, in consequence of the greater predisposition imparted to their bodies by men- struation, pregnancy, and parturition, and to their minds, by living so much alone in their families, are more predisposed to madness than men. A woman was admitted into our Hospital many years ago, who was deranged only during the time of her menstruation, and who in one of those periods hung herself with the string of her petti- coat. Of 1664 patients admitted into the Beth- lehem Hospital, between the years 1784, and 1794, eighty-four of them were women in whom madness followed parturition. I have been con- sulted in two cases, and I have heard of a third, in which madness was induced by the solitude of a country life, in women who had been accustom- ed to live in a large social and domestic society. Of 8874 patients admitted into the Bethlehem Hospital in London, between the years 1748 and 1794, four thousand eight hundred and thirty- two were women ; nearly a fiftH more than men. In St. Luke's Hospital in London, the proportion of women to men who have been admitted in a given number of years is in the ratio of three to two. But this disproportion of women to men, 60 ON THE DISEASES who are affected with madness, is by no means universal. In a Hospital for mad people in Vi- enna, one hundred and seventeen men were ad- mitted in a given number of years, and but ninety- four women. In a Hospital of the same kind at Berlin, twice as many males were admitted in a given time as females. More of the former than of the latter have been admitted into the Penn- sylvania Hospital. In all these cases accidental circumstances, such as the want of accommda- tions suited to female delicacy, or deep rooted prejudices against public mad-houses, and a pre- ference of such as are private, may have lessened the proportion of women in the above instances, while the evils of war, bankruptcy, and habits of drinking, which affect men more than women, and which vary in their influence upon the mind in different countries, may have produced more in- stances of madness in the former than in the latter sex. Perhaps it would be correct to say, women are more subject to madness from natural causes, and men from such as are artificial. What has been said under this head applies more particularly to general madness; but, from many facts, I am led to believe that men are more subject to that grade of derangement, which has been called hypochondriasm, than women. The distressing impressions made upon the minds of OF THE MIND. 61 women frequently vent themselves in tears, or in hysterical commotions in the nervous system, and bowels, while the same impressions upon the minds of men pass by their more compact nervous and muscular fibres, and descend into the brain, and thus more frequently bring on hypochondriac insanity. If this remark be correct, it will con- firm Dr. Heberden's assertion, that men are more disposed to suicide than women, for it necessarily follows their being most subject to that state of madness. Where the instances of suicide are more frequent among women than men, it is in those cases only in which the former are exposed to sudden paroxysms of vexation and despair. VI. Single persons are more predisposed to madness than married people. Of seventy-two insane patients in the Pensylvania Hospital, whose condition relative to this question, was ascertained by my young friends Dr. Moore and Mr. Jenny, in the month of April 1812, forty-two had never been married, and five were widows and widowers, at the time they became deranged. The absence of real and present care, which give the mind leisure to look back upon past, and to anticipate future and imaginary evils, and the inverted operation of all the affections of the 62 ON THE DISEASES heart upon itself, together with the want of relief in conjugal sympathy from the inevitable distresses and vexations of life, and for which friendship is a cold and feeble substitute, are probably the reasons why madness occurs more frequently in single, than in married people. Celibacy it has been said is a pleasant breakfast, a tolerable din- ner, but a very bad supper. The last comparison will appear to be an appropriate one, when we consider further, that the supper is not only a bad quality, but eaten alone. No wonder it sometimes becomes a predisposing cause of madness. VII. The rich are more predisposed to mad- ness than the poor, from their exposing a larger surface of sensibility to all its remote and exciting causes. Even where mental sensibility is the same in both those classes of people, the disease is prevented in the latter, by the constant pressure of bodily suffering, from labour, cold, and hun- ger. These present evils defend their minds from such as are past and anticipated ; and these are the principal causes of madness. When it occurs in poor people, it is generally the effect of corporeal causes. VIII. " Great wit, and madness," are said by Dryden " to be nearly allied." If he meant by OF THE MIND. 63 this affinity between wit and madness, the rapid exercises of the mind in associating similar and dissimilar ideas of words which are peculiar to both, the remark is a correct one; but if he meant that great Wits are more predisposed to madness than other people, the remark is opposed by all that is known of the solidity of understanding, and correctness of conversation and conduct of Butler, Chesterfield, Franklin, Johnson, and many other distinguished men who possessed the talent of wit in an eminent degree. Nor is the remark true if the term wit be intended to designate men of great understandings. Their minds are sometimes worn away by intense and protracted study, but they are rarely perverted by madness. The vigorous mind of Dean Swift perished gradually only from the former cause. Where madness has been in- duced by intense and protracted application to books, it has generally been in persons of weak intellects who were unable to comprehend the subjects of their studies. IX. Certain occupations predispose to mad- ness more than others. Pinel says, poets, pain- ters, sculptors, and musicians, are most subject to it, and that he never knew an instance of it in a chymist, a naturalist, a mathematician, or a natural philosopher. The reason of this will be understood by recollecting what was said under 64 ON THE DISEASES the preceding head. The studies of the former, exercise the imagination, and the passions, while the studies of the latter interest the understand- ing only. Dr. Arnold tells us, he has observed mechanics to be more affected with madness than merchants and members vof the learned profes- sions. This may arise from the vague and dis- tracting exertions of genius, unassisted by educa- tion ; or from corporeal causes, to which their em- ployments expose them more than the classes of men that have been mentioned. Of the effects of the former of those causes, I once saw an instance in a house carpenter, who became de- ranged in consequence of an unsuccessful attempt to contrive a new kirtH of stair-case. More far- mers it has been said become deranged than per- sons of the same grade of intellect and indepen- dence in cities. If this be the case, it must be ascribed to the greater solitude of their lives, more especially in the winter season, and to their being more exposed from labour and accidents, to its corporeal causes. X. Certain climates predispose to madness. It is very uncommon in such as are uniform- ly warm. Dr. Gordon informed me in his vi- sit to Philadelphia in the year 1807, that he had never seen nor heard of a single case of madness during a residence of six years in the OF THE MIND. 65 province of Berbice. It is a rare disease in the West Indies. While great and constant heat increases the irritability of the muscles, it gra- dually lessens the sensibility of the nerves and mind, and the irritability of the blood-vessels, and in these I formerly supposed the predis- position to madness to be seated. It is more common in climates alternately warm and cold, but most so, in such as are generally moist and cold, and aecompained at the same time with a cloudy sky. Instances of it are said to be most frequent in England in the month of November, at which time the weather is unusually gloomy from the above causes. Even the transient oc- currence of that kind of weather in the United States has had an influence upon this disease. In the month of May in the year 1806 it pre- vailed to a great degree, during which time three patients in the Pennsylvania Hospital made un- successful attempts upon their lives, and a fourth destroyed himself. Two instances of suicide oc- curred in the same month in Philadelphia. XI. Certain states of society, and certain opin- ions, pursuits, amusements, and forms of govern- ment, have a considerable influence in predispos- ing to derangement. It is a rare disease among savages. Baron Hombolt informed me, that he i 60 ON THE DISEASES did not hear of a single instance of it among the uncivilized Indians in south America. Infidelity and atheism are frequent causes of it in christian countries. In commercial countries, where large fortunes are suddenly acquired and lost, madness is a common disease. It is most prevalent at those times when speculation is substituted to regular commerce. The mad-houses in Eng- land were crowded with patients before, and af- ter the bursting of the South Sea bubble in the year 17 0. In the United States, madness has encreased since the year 1790. This must be ascribed chiefly to an increase in the number and magnitude of the objects of ambition and avarice, and to the greater joy or distress, which is pro- duced by gratification or disappointments in the pursuit of each of them. The funding system, and speculations in bank scrip, and new lands, have been fruitful sources of madness in our country. Sixteen persons perished from suicide in the city of New York, in the year 1804, in most of whom it was supposed to be the effect of mad- ness, from the different and contrary events of speculation. Even the profit and losses of regular trade and agricultural labour, now and then pervert the understanding. A respectable merchant died of madness in the Pennsylvania Hospital, in the OF THE MIND. 67 year 1794, induced by a successful East India voyage. A farmer near Albany, who refused to take twenty shillings a bushel for a large quantity of wheat, in the year 1798, became insane from the sudden reduction of its price. Suicide was induced in a farmer of great wealth, in York county, in Pennsylvania, in the spring of 1812, by a similar disappointment, in obtaining a less price than he had been previously offered for a quantity of clover seed. Gaming is an occasion- al cause of madness in some countries At Pe- nang in the East Indies, where men often stake their wives upon the issue of a game, this disease is very common. The unfortunate gambler often rises from his seat in a fit of derangement, and sallies out into the street with instruments of murder in his hands. A bell is rung at this time, which drives people into their houses, to avoid being killed. A late German writer has remark- ed, that nervous diseases increase in the cities of Germany in proportion to the fondness of their citizens for seeing tragedies. It is easy to con- ceive they may extend their effects a little fur- ther, so as to excite morbid commotions in the blood-vessels of the brain. I have heard the greater frequency of madness in England, than in some other countries, ascribed in part to its inhabitants preferring tragedy to comedy, in their 68 ON THE DISEASES stage entertainments. The real emotions excited by these exhibitions of imagnary distress are never accompanied with an effoi t to relieve it, by which means there is an accumulation and reflux of sensation in the mind, that cannot fail of affect- ing the nerves and brain, and thereby to predis- pose to, or induce madness. Certain forms of government predispose to madness. They are those in which the people possess a just and ex- quisite sense of liberty, and of the evils of arbi- trary power, against which complaints are stifled by a military force. The conflicting tides of the public passions, by their operation upon the un- derstanding, become in these cases a cause of derangement. The assassination of tyrants and their instruments of oppression is generally the effect of this diease. That madness is thus in- duced, I infer from its occurring so rarely from a political cause in the United States. I have known but one instance of it, and that was in a gentleman who had been deranged some years before from debt, contracted by extravagant living. In a government in which all the power of a country is representative, and elective, a day of general suffrage, and free presses, serve, like chimnies in a house, to conduct from the indi- vidual and public mind, all the discontent, vexa- tion, and resentment, which have been generated OF THE MIND. 69 in the passions, by real or supposed evils, and thus to prevent the understanding being injured by them. In despotic countries where the public passions are torpid, and where life and property are se- cured only by the extinction of the domestic affections, madnesc is a rare disease. Of the 'mth of this remark I have been satisfied by Mr. Stewart, the pedestrian traveller, who spent some time in Turkey : also by Dr, Scott, who accom- panied lord M'Cartney in his embassy to China; and by Mr. Joseph Roxas, a native of Mexico, who passed nearly forty years of his life among the civilized but depressed natives of that coun- try. Dr. Scott informed me that he heard of but a single instance of madness in China, and that was in a merchant who had suddenly lost 100,0001. sterling by an unsuccessful speculation in gold dust. Mr. Carr, in his Northern Summer, tells us, that madness is an uncommon disease in Russia. It is a rare thing, says this professional traveller, to see a Russian peasant angry. He even per- suades and reasons with his horse, when he wishes him to quicken his gait. It is to the long pro- tracted civil and ecclesiastical tyranny of the late 70 ON THE DISEASES government of Spain, that we must ascribe the small number of maniacs in all the hospitals in that country. They amounted, according to Mr. Townsend, in the year 1786, to but 664, in a population which produces in Great Britain be- tween 4,000 and 5,000 ; 2,600 of whom are in the city and neighbourhood of London. Habits of oppression in all those cases expend the ex- citability of the passions, and prevent their re-act- ing upon the brain. But in some instances the understanding decays with the passions, in des- potic countries. This state of the mind has been called fatuity. It is very common in Turkey and China. The inirritable or non-estic state of the brain upon which this disorder depends, is induced in those countries without previous morbid excite- ment in the same manner that the disorder called hepatalgia is induced, without previous hepatisis or obvious and sensible inflammation in the liver, in the East and West Indies. XII. Revolutions in governments which are often accompanied with injustice, cruelty, and the loss of property and friends ; and where this is not the case, with an inroad upon ancient and deep-seated principles and habits, frequently mul- tiply instances of insanity. Mr. Volney informed me, in his visit to this city in the year 1799, that OF THE MIND. 71 there were three times as many cases of madness in Paris in the year 1795, as there were before the commencement of the French Revolution.- It was induced, I shall say hereafter, in several in- stances, by the events of the American Revolu- tion. XIII. Different religions, and different tenets of the same religion are more or less calculated to induce a predisposition to madness. Dr. Sheb^- beare says there are fewer instances of suicide (which is generally the effect of madness) in catholic, than in protestant countries. He as- cribes it to the facility with which the catholics relieve their minds from the pressure of guilt, by means of confession and absolution. This assertion and the reasoning founded upon it are rendered doubtful by 150 suicides having taken place in the catholic city of Paris in the year 1782, and but 32 in the same year in the pro- testant city of London. It is probable however the greater proportion of infidels in the former, than in the latter city at that time, may have occasioned the difference in the number of deaths in the two places, for suicide will naturally fol- low small degrees of insanity, where there are no habits of moral order from religion, and no belief in a future state. Dr. Shebbeare's asser- 72 ON THE DISEASES tion is rendered still less probable, by considering the usual effects of solitude upon the human mmd, and this we know acts with peculiar force in the cells of monks and nuns. This remark is not the result of reasoning a priori. Of between 240 and 250 deranged people, who were confined at one time in a mad-house in the city of Mexico, Mr. Roxas informed me, in a great majority of them the disease had been contracted in those re- cluse and gloomy situations. There are certain tenets held by several protes. tant sects of christians which predispose the mind to derangement. They shall be noticed in another place. I shall conclude the history of the remote ex- citing and predisposing causes of madness by the following remarks." 1. Its remote causes generally induce predis- posing debility. Its exciting causes more com- monly induce that morbid excitement in the blood-vessels of the brain in which madness is seated, but the sudden and violent action of a re- mote cause is often sufficient for that purpose without the aid of an existing cause. OF THE MIND. 73 2. Both the remote and exciting causes of mad- ness produce their morbid effects more certainly^ prompdy, or slowly, according as the system is more or less predisposed to the disease by the causes formerly mentioned, 3. The predisposing causes of madness some- times act with so much force, as to induce it without the perceptible co-operation of either a remote or an exciting cause. The remote causes of madness likewise act with so much force in some instances as to induce it without the perceptible co- operation of a predisposing or exciting cause. 4. The predisposing causes of madness in like manner sometimes act with so much force as to induce it without the perceptible co-operation of a remote or an exciting cause. K CHAPTER III. Of Partial Intellectual Derangement, and par- \ ticularly of Hypochondriasis* PARTIAL derangement consists in error in opi-, nion, and conduct, upon some one subject only; P± with soundness of mind upon all, or nearly all ether subjects. The error in this case is two-fold. It is directly contrary to truth, or it is dispropor- tioned in its effects or expected consequences, to the causes which induce them. It has been divid. ed by the nosologists according to its objects. When it relates to the persons, affairs, or condi- tion of the patient only, and is attended with dis- tress, it has been called hypochondriasis. When it extends to objects external to the patient, and is attended with pleasure, or the absence of dis- J tress, it has been called melancholia. They are different grades only of the same morbid actions ^ in the brain, and they now and then blend their symptoms with each other. OF THE MIND. 75 I wish I could substitute a better term than hypochondriasis, for the lowest grade of derange- ment. It is true the hypochondriac region is dis- eased in it j so it is after autumnal fevers, and yet we do not designate the obstructions induced by those fevers by that name. It would be equally proper to call every other form of madness hypo- chondriasm, for they are all attended with more or less disease or disorder in the liver, spleen, sto- mach and bowels, from which the name of hypo- chondriasm is derived. But I have another ob- jection to that name, and that is, it has unfortu- nately been supposed to imply an imaginary dis- ease only, and when given to the disease inques- tion is always offensive to patients who are affect- ed with it. It is true, it is seated in the mind ; but it is as much the effect of corporeal causes as a pleurisy, or a bilious fever. Perhaps the term tristimania might lie used to express this form of madness when erroneous opinions respect- ing a man's person, affairs, or condition, are the subjects of his distress. I object likewise to the term melancholia, when used, as it is by Dr. Cullen, to express partial mad- ness from external causes. 76 ON TUE DISEASES 1. Because it is sometimes induced by causes that arc not external to the patient, but connected with his person, affairs, or condition in life; and, 2. Because it conveys an idea of its being seated in the liver and derived from vitiated or obstructed bile. Now the seat of the disease, '\ from facts formerly mentioned, appears to be in the brain, and morbid or obstructed bile is evi- dently an accidental symptom of it. Perhaps it would be more proper to call it amenomania, from the errors that constitute it, being ge- f nerally attended with pleasure, or the absence of distress. The hypochondriasis, or tristimania, has some- times been confounded with hysteria, but differs from it, 1. In being induced chiefly by mental causes, and particularly by such of them as act upon the understanding, through the medium of the passion and moral faculties. Hysteria is pro- t duced chiefly by corporeal causes. Its paroxisms only are excited by such as are mental. The -i chronic operation of the passions, so far from in- ducing it, sometimes cures it, or changes it into hypochondriasis OF THE MIND. 77 2. In affecting men more than women. 3. In affecting chiefly persons of sedentary em- ployments. 4. In the absence of globus hystericus. 5. In affecting the blood-vessels of the brain as well as the nerves. Hysteria affects the nerves and muscles only, and never the blood-vessels, so as to produce derangement, except for a short time, and only during its paroxysms. 6. The nerves in hypochondriasis are in a re- verse state from that which takes place in hysteria. In the former they are torpid, or in what Themi- son calls a strictum state. In the latter disease they are highly excitable, or what the same author has called a laxum state. These terms correspond with what Dr. Boerhaave has since denominated a rigid and lax state of the fibres. 7. Hypochondriasis is generally attended with costiveness or diarrhoea, and durable distress of mind, which are transient affections only in hyste- ria ; and, 78 ON THE DISEASES 8. Hypochondriasis is relieved by warm wea- ther and warm drinks. Hysteria is made worse by each of them. Hypochondriasis, or tristimania, is to hysteria what a typhus fever is to inflammatory fever. It is often combined with it, and sometimes alter- nates w uh it, and, when cured, it passes cut of i the system with symptoms of hysteria, in all those 1 cases in which it was preceded by them. I beg «' the attention of the reader to this view of these ^ two forms of disease. It is intended to destroy ' the nosological distinctions between them. As well might we divide the first and last stages of a fever by specific characters, as divide those two grades of morbid excitement by specific names. I shall now deliver a history of the most cha- racteristic symptoms of the two different forms of partial derangement that have been mentioned, and afterwards take notice of the remedies proper for each of them. I shall begin with hppochondri- ? asis, or tristimania. The symptoms of this form of derangement as they appear in the body are, dyspepsia; costive- ness or diarrhoea, with slimy stools; flatulency OF THE MIND. 79 pervading the whole alimentary canal, and called in the bowels borborigmi; a tumid abdomen, es- pecially on the right side; deficient or preterna- tural appetite; strong venereal desires, accompa- nied with nocturnal emissions of semen; or an absence of venereal desires, and sometimes impo- tence ; insensibility to cold ; pains in the limbs at times, resembling rheumatism ; cough; cold feet; palpitation of the heart; head-ach; vertigo; teni- tus aurium ; a thumping like a hammer in the tem- ples, and sometimes within the brain; a disposi- tion to faint; wakefulness, or starting in sleep ; indisposition to rise out of bed, and a disposition to lie in it for days, and even weeks; a cool and dry skin, and frequently of a sallow colour, from the want of a regular discharge of bile from the liver, and its absorption into the blood. While the alimentary canal is thus depressed, and the blood-vessels, nerves and muscles, robbed of nearly all their excitement, or possess it in parts of the body only, the lymphatic system is often preternaturally excited; hence we frequendy observe in this disease a constant and increased discharge of urine. The characteristic symptom of this form of derangement, as it appears in the mind, is distress, 80 ON THE DISEASES the causes of which are numerous, and of a per- sonal nature. I shall enumerate some of them, as they have appeared in different people. They relate, 1, to the patients body. He erroneously believes himself to be afflicted with various dis- eases, particularly with consumption, cancer, stone, and above all, with impotence, and the venereal disease. Sometimes he supposes himself to be poisoned, or that his constitution has been ruined by mercury, or that the seeds of the hydrophobia «! are floating in his system. 2. He believes that he has a living animal in his body. A sea captain, formerly of this city, believed for many years that he had a wolf in his liver. Many persons have fancied they were gradually dying, from animals of other kinds preying upon different parts of their bodies. 3. He imagines himself to be converted into an ani- mal of another species, such as a goose, a cock, a dog, a cat, a hare, a cow, and the like. In this case he adopts the noises and gestures of the ani- mals into which he supposes himself to be trans- formed. 4. He believes he inherits, by transmigration, ■* the soul of some fellow creature, but much oftener of a brute animal. There is now a mad- OF THE MIND. 81 man in the Pennsylvania Hospital who believes that he was once a calf, and who mentions the name of the butcher that killed him, and the stall in the Philadelphia market on which his flesh was sold previously to his animating his present body. 5. He believes he has no soul. The late Dr. Percival communicated to me, many years ago, an account of a dissenting minister in England who believed that God had annihilated his soul as a punishment for his having killed a high-way man by grasping him by the throat, who attempt- ed to rob him. His mind was correct upon all other objects. 6.He believes he is transformed into a plant. In the Memoirs of the Count de Maurepas we are told this error took possession of the mind of one of the princes of Bourbon to such a degree, that he often went and stood in his garden, where he insisted upon being watered in common with all the plants around him. 7. The patient afflicted with this disease some, times fancies he is transformed into glass. t 82 ON THE DISEASES 8. He believes, that by discharging the con- tents of his bladder, he shall drown the world. 9. He believes hinself to be dead. It is worthy of notice, in all these cases of erroneous judgment, the patients reason correctly, that is, draw just inferences from their errors. Thus the prince of Bourbon, when he supposed himself to be a plant, reasoned justly when he insisted upon being watered. In like manner, the hypocondriac who supposes himself to be dead, reasons with the same correctness when he stretches his body and limbs upon a bed or a board, and assumes the stillness and silence of the shroud. It is remarkable further, that all the erroneous opinions persons affected with this form of de- rangement entertain of themselves are of a de- grading nature. Put again. The distress of a hypochondriac is derived from errors respecting, 1, his out- ward circumstances as they relate to his property. 2. The conduct of his friends, relations, or a mistress. OF THE MIND. 83 3. His birth place, and society of his family, when absent from them. 4. The state of his country. 5. His spiritual state. The mind, in its distress from all the above caus- es, is in a reverse state from that which was justnow mentioned, in drawing erroneous, or dispropor- tionate, conclusions from just premises. Thus the hypochondriac who possesses an income which he admits to be equal to all the exigencies of his family, reasons unjustly when he anticipates end- ing his days in a poor-house. In like manner the derangedfpenitent judges correctly when he be- lieves that he has offended his Maker, but he rea- sons incorrectly when he supposes he has exclu- ded him from his mercy. In the hypochondriasis from all the causes that have been mentioned, the patients are for a while peevish and sometimes irascible. The lightest noises, such as the grating of a door upon its hinges, or its being opened and shut suddenly, produce in them anger or terror. They quarrel with their friends and relations. They change their physicians and remedies, and sometimes thev 84 ON THE DISEASES discover the instability of their tempers by settling and unsettling themselves half a dozen times in different parts of their native country, or different foreign countries, in the course of a few years, leaving each of them with complaints of their climate, provisions, and the manners of their in- habitants. The hypochondriasis, or tristimania, like most other diseases, has paroxysms, and remissions or intermissions, all of which are influenced by many circumstances, particularly by company, wine, exercise, and, above all, the weather. A pleasant season, a fine day, and even the morning sun, often suspend the disease. Mr Cowper who knew all its symptoms by sad ex- perience, bears witness to the truth of this re- mark, in one of his letters to Mr. Haley. "I rise," says he, " cheerless and distressed, and brighten as the sun goes on." Its paroxysms are sometimes denominated " low spirits" They continue from a day, a week, a month, a season, to a year, and sometimes longer. The intervals differ, 1, in being accompanied with preternatu- ral high spirits. 2. In being attended with remis- sions only ; and, 3, with intermissions, or, in OF THE MIND. 85 other words, with correctness and equanimity of mind. The extremes of low and high spirits which occur in the same person, at different times, are happily illustrated by the following case. A phy- scian in one of the cities of Italy was once con- sulted by a gentleman who was much distressed with a paroxysm of this intermitting state of hy- pochondriasm. He advised him to seek relief in convivial company, and recommended to him in particular to find out a gentleman of the name of Cardini, who kept all the tables in the city to which he was occasionally invited in a roar of laughter. " Alas ! Sir," said the patient, with a heavy sigh, "I am that Cardini." Many such characters, alternately marked by high and low spirits, are to be found in all the cities in the world. But there are sometimes flashes of apparent cheerfulness, and even of mirth, in the intervals of this disease, which are accompanied with la- tent depression of mind. This appears to have been the case in Mr. Cowper: hence, in one of his letters to Mr. Hayley, he says, " I am cheer- ful upon paper, but the most distressed of all 86 ON THE DISEASES creatures." It was probably in one of these oppo- site states of mind that he wrote his humerous bal- lad of John Gilpin. In the history of hypochondriasm, as far as it has been given, there is a combination of some of the symptoms of hysteria from the nervous system being partially or alternately in a strictum or lax- um, or, in other words, in an inirritable or irrita- ble state, and from the blood-vessels being alter- nately in a diseased and sound state. This mixture of the symptoms of hypochon- driasis and hysteria, in those two opposite states of the system, is described with great accuracy in the following letter from a gentleman in Virginia, which I received a few years ago, containing the history of his own case. January 25, 1808. Sir, " I write you to seek relief in a case of disease of the most inveterate, though not uncommon, nature. It is a nervous affection of the most ob- stinate kind. An apathy and torpor of the bowels and stomach, and a susceptibility of the mind ex- ceeding all description: loss of sleep to an alarm- OF THE MIND. 87 ing degree at times, and the consequent debility, despair, subsultus tendinum, and paralytic sensa- tions in many parts of my body, are the principal evils I suffer. My mind is liable to be excited by trifling and unsubstantial causes ; disposed to cleave to unpleasant usages, to dwell on dreadful consequences from really trifling circumstances, to be appalled with vain apprehensions, and to cherish disgusts and disagreeable associations ; indeed, to labour under a fixidity of ideas which causes my misery. I was attacked in the winter 1800 and 1801, and since that time have suffered an immensity of distress, with long intervals, how- ever, of capacity for enjoyment. Moral causes are the sources of my afflictions. The barriers of reason are cobwebs to oppose to the intrusion of this host of enemies. Am I in a convivial com- pany ? I think of some unpleasant circumstance. Do I eat heartily? I still think; my mind can- not rise above its customary state of feebleness. When I lie down, this fixed image presents it- self. I am distressed, alarmed, my blood circu- lates rapidly, my brain is fired, a train of distress- ing ideas enter, and seize my mind : I am, as it were, all nerve ; the least noise is like a shock of thunder, so that for seven years 1 have been in the constant habit of stopping both ears with wax ; with intervals, however, of strength to bear noise, 88 ON THE DISEASES and sometimes even I am, as I think, almost well. I am within a few days of forty-four years of age; my appetite is always good ; I eat every thing, drink moderately of wine, have found no good from any regimen, though I have not pursued any regimen but a very short time. " I go to bed, my mind is distressed, I get a little quiet, and perhaps I am disposed to rest; at the moment of forgetfulness, which produces sound sleep, this image strikes my mind; I know what I am to suffer, am alarmed ; my blood rushes through the jugular vessels ; I hear my heart beat, and feel it thumping the whole night; my mind on fire, able to pursue no train of pleasant thought a moment; 1 get worse ; despair ; think of nothing but my wretched condition, till at last I lose seve- ral nights sleep; my pulse is low and threaded, and at last nature makes an effort and gradually restores me. Such is almost always my course. u I can assure you that no case of distress vexes my mind in which my conscience or my honour is implicated, or which would be even noticed by others. If I could indulge in religious duties and contemplations, to which my heart, my judgment, and natural disposition would lead me, it wouid, I really believe, cure me; but pre- OF THE MIND. 89 vious to my first attack, near eight years ago, in a previous state of debility and nervous affection, which pressed hard on my spirits, I wished to read on religious subjects, until all at once im- pious and profane ideas struck my mind : my soul recoiled, was shocked ; I tried to banish them; nothing would do; not a moment were those ideas absent; at last they seized so fast, that I lost many nights and days sleep ; and I was brought near the grave. I got better, and overcome, in some sort, this immoral influence ; but shall never be able to indulge as I wish in religious duties. My heart often expands with enthusiasm, and then I taste of the joys of heaven Now, Sir, can this dread- ful state of mind be cured ? Can I be made to possess less feeling, and more resolution to resist moral influences on the mind; to bear vexatious or distressing incidents : and to break this associ- ation, this fixidity of ideas ? " My feet, particularly my left foot, are always cold ; and when I labour under great anxiety, both feet have, when warm in bed, a sensation as if they were asleep (as we say) which is very distress- ing. My whole left side is affected more than the other; the auditory nerve of my left ear is affect- ed curiously, and unpleasantly, with sharp sounds, M 00 ON THE DISEASES as if the body touched the nerve: I cannot well describe it. " If I could be tranquil, 1 should be well. Whenever I can be moved by ambitious pros- pects, or entertain a desire for distinction, or any such passion, I am well. This is sometimes the case. When hopes or wishes of this sort take possession of my mind, they drive out other im- pressions ; then I feel well. Active employment, if I could get in it, would cure me, but I know of none. When I feel well, I am uncommonly cheer- ful, playful, and happy. " Now, Sir, I beg you, in consideration of suf- fering humanity, to take my case into your serious consideration, and extend to me the benefit of your advice." In proportion as the hypochondriac disease ad- vances, the symptoms of the hysteria, which are generally combined with it in its first stage, dis- appear, and all the systems in which the disease is seated acquire a uniformly torpid or irritable state. The remissions and intermissions which have been described, cease, and even the tran- sient blaze of cheerfulness, which now and then escapes from a heart smothered with anguish, OF THE MIND. 91 is seen no more. The distress now becomes constant. " Clouds return after every rain." Not a ray of comfort glimmers upon the soul in any of the prospects or retrospects of life. " All is now darkness without and within." These poignant words were once uttered by a patient of mine with peculiar emphasis, while labouring un- der this stage of the disease. Neither nature nor art now possess a single beauty, nor music or poetry a single charm. The two latter often give pain and sometimes offence. In vain do love and friendship, and domestic affection, offer sympa- thy or relief to the mind in this awful situation. Even the consolations of religion are rejected, or heard with silence and indifference. Night no longer affords a respite from misery. It is passed in distracting wakefulness, or in dreams more terrible than waking thoughts; nor does the light of the sun chase away a single distressing idea. " I rise in the morning," says Mr. Cowper, in a letter to Mr. Haley, " like an infernal frog out of AcHeron, covered with the ooze and mud of me- lancholy." No change of place is wished for that promises any alleviation of suffering. " Could I be translated to paradise," says the same elegant historian of his own sorrows, in a letter to Lady Hesketh, " unless I could leave my body behind me, my melancholy would cleave to me there.'' 92 ON THE DISEASES But the last and worst stage of this form of de- rangement remains yet to be described. After it has completely put off all its hysterical symp- toms, the patients fly for relief to such stimuli as act upon the body, in order to counteract the in- supportable pressure of distress upon their minds. They take snuff, or chew tobacco. They eat voraciously, and drink wine and spirits, or take laudanum, in large quantities, when they are able to procure them. Sometimes the pain of a bodily disease suspends for a short time their mental distress. Mr. Boswell, in his life of Dr. John- son, relates a story of a London tradesman, who, after making a large lortune, retired into the country to enjoy it. Here he became deranged with hypochondriasis, from the want of employ- ment. His existence became finally a burden to him. At length he was afflicted with the stone. In a severe paroxysm of this disease, a friend sympathised with him. " No, no," said he, " don't pity me, for what I now feel is ease, com- pared with that torture of mind from which it re- lieves me." A woman in this city bore a child, while she was afflicted with this disease. She declared, immediately afterwards, that she felt no more pain from parturition, than from a trifling fit of the colic. Where counteracting pains of the body are not induced by nature or accident, «F THE MINB. 93 to relieve anguish of mind, patients often inflict them upon themselves. Walking barefooted over ground covered with frost and snow was resorted to by a clergyman of great worth in England for this purpose. Carden, an eminent physician of the fifteenth century, made it a practice to bite his lips, and one of his arms, also to whip his legs with rods, in order to ease the distress of his mind. Kempfer tells us that prisoners in Japan, who often became partially deranged from distress, used to divert their mental anguish by burning their bodies with moxa. The same degree of pain, and for the same purpose, is often inflicted upon the body, by cutting and mangling it in parts not intimately connected with life. But bodily pain, whether from an accidental disease, or in- flicted by the patients upon themselves, is some- times insufficient to predominate over the distress of their minds. Dr. Heberden mentions an in- stance of a man who was naturally so much afraid of pain that he dreaded even being bled, who in a fit of low spirits cut off his penis and scrotum with a razor, and declared, after he recovered the natural and healthy state of his mind, that he felt not the least pain from that severe operation. A similar instance of insensibility to bodily pain is related by Dr. Ruggicri, an Italian physician, of a hypochon- driac madman of the name of Loval, who fixed \ 94 ON THE DISEASES himself upon a cross, and inflicted the same wounds upon himself, as far as he was able, that had been inflicted upon our Saviour. He was discovered in this situation, and taken down alive. During the paroxysms of his madness, he felt no pain from dressing his wounds, but complained as soon as they were touched, in the intervals of his disease. But this is not all. Hypochondriac distress seeks relief in an evil still greater than bodily pain. Can any thing be anticipated more dreadful than universal madness ? and yet I once attended a lady in this city, whose sufferings from low spirits were of such a nature, that she ar- dently wished she might lose her reason, in order thereby to be relieved from the horror of her thoughts. This state of mind was not new in this disease. Shakspeare has described it in the following lines, in his inimitable history of all the forms of derangement, in the tragedy of King Lear. They are as truly philosophical, as they are poetical. --------" Better I were distract; So should my thoughts be sever'd from my griefs. And woes, by wrong imaginations, lose The knowledge of themselves." OF THE MIND. 95 But the most awful symptom of this disease remains yet to be mentioned, and that is despair. The marks of the extreme misery included in this word are sometimes to be seen in the coun- tenances and gestures of hypochondriacs in a Hospiial; but as it is difficult to obtain from such persons a history of their feelings, I shall en- deavour to give some idea of them in the follow- ing account, communicated to me by a clergyman who passed four years and a half in that state of mind. He said " he felt the bodily pains and mental anguish of the damned; that he slumbered only, but never slept soundly, during the long period that has been mentioned ; that he lost his appetites, and passions, so as to desire and relish nothing, and to love and hate no one ; that his feet were constantly cold, and the upper part of his body warm; that he lost all sense of years, months, weeks, days, and nights and even of morning and evening; that in this respect, time was to him, no more." During the whole period of his misery, he kept his hands in constant motion towards his head and thighs, and ceased not constantly to cry out, " wretched man that I am ! I am damned; oh, I am damned everlastingly." 96 ON THE DISEASES Terrible as this picture of despair is, the dis- ease has symptoms which mark a still greater de- gree of misery. It sometimes creates such a dis. gust of life, as to make the subjects of it wish to die. How undescribable, and even incomprehen- sible, must be that state of mind, which thus ex- tinguishes the deep seated principle of the love of life ! In the exquisite tortures of the stone, and colic, and even under the progress of an ex- cruciating and mortal cancer, men are willing, nay anxious, to live; of course the sufferings from the anguish of mind I have described, exceed the sufferings from those diseases. But there is a symptom of despair which places its horrors beyond a mere wish to die. It often drives the distracted subject of it to precipitate the slow approaches of death with his own hand. A pis- tol, a razor, a river, a mill-dam, a halter, or laud- anum, are the means usually resorted to for this purpose. Sometimes the instruments of death are of a more painful nature. I have once seen the bodyof a Russian officer mangled with thirteen wounds inflicted by himself. He had fallen into despair in consequence of debts contracted in a foreign country. Sometimes a horror is enter- tained by persons in this situation at the crime of suicide, but, in order to escape from life, they provoke death from the hands of go- OF THE MIND. 97 vernment by committing murder; many instances of this kind are to be met with, not only in the records of medicine, but in nur public newspapers. Dreadful as this state of mind is, there is one still more distressing, and that is the desire, and fear of death operating alternately upon the mind. I have seen this state of hypochondriasm. It was in the lady who wished to be relieved from the horror of her thoughts by the complete loss of her reason. After the history that has been given of the distress, despair, and voluntary death, which are induced by that partial derangement which has been described, I should lay down my pen, and bedew my paper with my tears, did I not know that the science of medicine has furnished a reme- dy for it, and that hundreds are now alive, and happy, who were once afflicted with it. Blessed science! which thus extends its friendly empire, not only over the evils of the bodies, but over those of the minds, of the children of men ! N 98 ON THE DISEASES CHAPTER IV. Of the Remedies for Hypochondriasis or Tristi- mania. THE remedies for this form of derangement di- vide themselves into two classes. I. Such as are intended to act directly upon the body; and,, II. Such as are intended to act indirectly upon the body, through the medium of the mind. I. Before we proceed to administer the reme- dies that are indicated under our first head, it will be proper carefully to review the history of all the remote and exciting causes of this disease, and, when possible, to remove them. If this be im- practicable, or if the disease continue from habit after all its causes have been removed, recourse should be had to, OF THE MIND. 99 1. Bloodletting, if the pulse be tense, or full; or depressed, without either fulness, or ten- sion. I have prescribed this remedy with success, and thereby in several instances suddenly pre- pared the way for its being cured in a few days by other medicines. I was led to use it by the following fact, communicated to me by the late Dr. Thomas Bond. A preacher among the Friends called upon him, to consult him in this state' of madness. He said he was possessed of a devil, and that he felt him constantly in aches and pains in every part of his body. The Doctor felt his pulse, which he found to be full and tense. He advised him to sit down in his parlour, and per- suaded him to let him open a vein in his arm. While the blood was flowing the patient cried out, " I am relieved, I felt the devil fly out of the orifice in my vein as soon as it was opened." From this time he recovered rapidly from his derangement. The advantages of bleeding are evinced still fur- ther by the relief obtained in this disease by the loss of blood from the haemorrhoidal vessels, and by other accidental haemorrhages. But, if expe- rience had not thus established the efficacy of this remedy, its use would be suggested by the habits of such patients, of indulging their appetites, not only to satisfy hunger, but to suspend their dis- tress ; and by congestions of blood in the liver 100 ON THE DISEASES and spleen, which usually takes place in this dis- ease. After bleeding, if it be required. 2. Purges should be given. They are indi- cated by the obstructions of the viscera, and torpor of the alimentary canal. They often bring away black bile, and sometimes worms. The more ac- tive purges, particularly aloes, jalap, and calomel, should be preferred in this disease. The daughters of Praetus, v ho supposed themselves to be cows, were cured by Melampus by means of hellebore, which is of a purging nature. The medicine has ever since bore his name. 3. Emetics, by exciting the stomach, often remove morbid excitement from the brain, and thus restore the mind to its healthy state. They moreover assist purges in exciting the alimentary canal, and in dislodging obstructions from the ab- dominal viscera. 4. A reduced diet, consisting of food and drinks that contain but little nourishment should be combined with the three remedies that have been mentioned. As the stomach is frequently in a dyspeptic state, the aliment and drinks should OF THE MIND. 101 consist of such articles as are least disposed to in- crease or produce a morbid acid in it. After reducing the action of the blood-vessels to a par of debility with the nervous system, or, to borrow an allusion from a mechanical art, after plumbing those two systems, the remedies should consist, 5. Of STIMULATING ALIMENT, DRINKS and MEDICINES, The diet should consist of solid animal food, with such vegetables as are least disposed to aci-j dity, and both should be rendered palatable by condiments. The drinks should consist of old Madeira or sherry wine, and porter diluted with water, or taken alone, provided the stomach be not affected with a morbid acid. I have once known this disease cured by the liberal use of Madeira wine. In some cases, old claret is better received by the stomat*h» than the white wine£, from its containing less fermentable matter in it. The drinks should be taken warm, for the stonv.dh is generally too weak to react under the sedative operation of such as arc cold. Warm tea and cof- fee, made weak, are generally grateful to thgr sto- mach, and should be advised, when it i^not af- 102 ON THE DISEASES fected with dyspepsia. The celebrated Mr. Burke often relieved the low spirits which were induced by the solicitude and vexations of his political life, by sipping a tea-cup full of hot water. In cases of dyspepsia, or indigestion, as little drink as possible should be taken with food. The me- dicines proper in this disease should be the differ- ent preparations of iron. I know they have been said to be hurtful in it. It is true they are often ineffectual, but this is because the system is re- duced below their stimulus in their ordinary doses. When given in large doses, mixed with ginger, or black pepper, and the common bitters of the shops, and persisted in for several months, they are powerful medicines. Tar, in the form of pills, or infused in water, and garlic in substance, or infused in peppermint tea, afford great relief in this disease, more especially when the stomach is affected. Magnesia, lime-water and milk, and the alkaline salts, should be given to relieve aci- dity in the stomach, should that symptom of dys- pepsia call for them. Assafcetida is an excellent medicine in this depressed state of the system, and preferable to any of the common foetid gums that are in use to exhilarate the spirits. But our principal reliance for this purpose should be upon opium. Mr. Cowper says, ten drops of laudanum, taken occasionally, saved him from being " de- OF THE MIND. 103 voured by melancholy." This noble medicine, which has been happily called " the medicine of the mind," has many advantages over ardent spirits as a cordial. It affords more prompt re- lief ; a habit of attachment to it is more slow- ly formed, and more easily broken. It does not pollute the breath, nor does it ever tend to excite, or increase that hysterical irritability of temper which is sometimes connected with this disease. However useful ardent spirits may be in transient diseases, they cannot be used in such as are of a chronic nature, without inducing such a fondness for them as not only to prevent their acting as remedies, but to convert them into poisons, often alike fatal to the soul and body. 6. The warm bath, applied in the form of water, or vapour, and rendered more stimulating, if necessary by the addition of saline or aromatic substances to it. The heat of the water should be a little above that of the body. It does most ser- vice when it induces sweats. Mr. Cowper was always relieved by that discharge from his skin. 7. The cold bath. This remedy should not be advised until the system has been prepared for it by the previous use of the warm bath. 104 ON THE DISEASES 8. Frictions to the trunk of the body and limbs. These tend very much to excite the cu- taneous extremities of the nerves and blood-ves- sels, and thus to equalize the excitement of the system. I have known two instances in which a recovery from this disease succeded an attack of the itch. The remedy to this case was proba- bly the pleasurable sensation excited by scratch- ing, in order to relieve it. 9. Exercise, especially upon horseback. La- bour is still more useful, particularly in the open air. 10. The excitement of pain. I mentioned the accidental effects of the pain of a stone in the bladder, and of burning moxa on the body, in suspending anguish of mind in the history of this disease. It may be excited in various ways. Mustard to the feet is generally sufficient for this purpose. I once attended a gentleman from Bar- badoes, who suffered great distress of mind from a hypochondriac gout which floated in his nerves and brain ; but no sooner did the gout fix, and ex- cite pain in his hands or feet, than he recovered his spirits and became pleasant and agreeable to all around him. OF THE MIND. 105 11. Salivation. Mercury acts in this dis- ease, ', by abstracting morbid excitement from the brain to the mouth. 2, By removing visceral obstructions. And, 3, by changing the cause of our patient's complaints, and fixing them wholly upon his sore mouth. The salivation will do still more service if it excite some degree of resent- ment against the patient's physician or friends. The effects of mercury in this disease, have some^ times been compared to those of a handful of shot shaken in a bottle, lined with filth and dirt, in or- der to clean it. It stimulates every part of the body, renders the vessels pervious to their natural juices, conveys morbid action out of the body by the mouth, and thus restores the mind to its na- tive seat in the brain. 12. Blisters and issues have been found useful in this form of madness. They are calcu- lated to excite the action of the skin, and to pro- duce what has been happily called a centrifugal direction of the fluids. They are more particularly indicated, if the disease have been induced by eruptions repelled from the skin. II. We come next in order to mention the remedies for the body, which are intended to act through the medium of the mind. The o 106 ON THE DISEASES first thing to be done by a physician, under thi- head, is to treat the disease in a serious manner. To consider it in any other light, is to renounce all observation in medicine. However erroneous a patient's opinion of his case may be, his dis- ease is a real one. It will be necessary, therefore, for a physician to listen with attention to his tedious and uninteresting details of its symptoms and causes. In some cases, patients wish to think their diseases are trifling, and attended with no danger, but in hypochondriasis they are always best satisfied in believing their disease to be difficult and dangerous. A physician should carefully avoid likewise speaking lightly of his patient's disease to his friends and neighbours, for he will take uncommon pains to discover, from them, his opinion of his case, and if it be differ- ent from that which has been given to him, he will not only reproach him with a want of can- dour, but will immediately seek relief from ano- ther physician. I once knew an instance of this kind in this city. The patient refused to see the physician afterwards, who had thus deceived him. In the worst grade of this disease, he will not bear contradiction, and hence it will be neces- sary to conform our remedies as much as possi- OF THE MIND. 107 ble to his erroneous opinions of the nature of his disease. If he believe himself to be affected with any of the diseases that were formerly named, medicines must be prescribed for them, and ad- ministered in a manner calculated to act upon his principle of faith, and to beget his confidence in them. In the more moderate grade of his errors upon the subject of his disease, contradic- tion, and reasoning, may be opposed to them. When these means are employed, the conduct of a physician should correspond with them. I once injured myself, and my patient, who sup- posed himself to be affected with the venereal disease, by prescribing for him a few mercurial pills, in compliance with his earnest solicitations, after having assured him that he had not a parti- cle of its virus in his system. I have in several instances removed all doubt upon the subject, by advising matrimony, or a renewal of conjugal in- tercourse, if my patients were married, and by offering them at the same time a bond for a large sum of money, if any bad consequences should follow their obedience to my advice. In this way I have made many gentlemen happy, and never in a single instance incurred the least discredit or blame. 10& on the diseases Persons afflicted with this form of derangement, I said formerly, now and then believe themselves to be poisoned. In this case it is sometimes ne- cessary to humour their error, and to prescribe suitable means to remove it. Dr. Cox, in his Treatise upon Insanity, has furnished us with an excellent precedent for this purpose. A gentle- man in England supposed a shirt which he had worn had been poisoned by his maid, and deter- mined to subject her to the punishment of the law. His physician humoured his belief and re- sentment, by pretending to have discovered a poisonous matter in his shirt, by means of some chymical experiments upon it, and concurred with him in prosecuting his maid for an intended mur- der. A new course was hereby given to his thoughts, and a new action excited in his brain, by which he was perfectly cured. Terror once cured, for a while, a patient of mine, of a belief that he had been poisoned by taking arsenic as a medicine, and that it had eaten out his bowels. A student of medicine to whom he told his tale, attempted to convince him of his error, upon which he begged him to open him, and to satisfy himself by examining the cavity of his belly. After some preparation, the student laid him upon a table, and drew the back of a knife OF THE MIND. 109 from one extremity of his belly to the other. " Stop, stop," said my patient, " I've got guts," and suddenly escaped from the hands of his ope- rator. His cure would probably have been dura- ble, after the use of this remedy, had not real dis- tress from another cause brought back that which was imaginary. If our patient imagine he has a living animal in' his body, and he cannot be reasoned out of a be- lief of it, medicines must be given to destroy it; and if an animal, such as he supposes to be in his body, should be secretly conveyed into his close stool, the deception would be a justifiable one, if it served to cure him of his disease. If our patient should believe himself to be transformed into an animal of another species by transmigration, or in any other way, our remedies should be accommodated to the grade of his mad- ness, and the nature of the animal into which he supposes himself to be changed. Ridicule has sometimes been employed with success in such cases. Mr. Pinel mentions an instance of its sudden efficacy in curing a watch-maker in Paris, who believed that his head had been cut off, and that he carried the head of a man who had been guillotined, instead of his own. 110 ON THE DISEASES A physician, formerly of this city used to di- vert his friends, by relating the history of a cure which had been performed of a patient in this form of madness, who believed himself to be a plant. One of his companions, who favoured his delusion, persuaded him he could not thrive with- out being watered, and while he made the patient believe, for some time, he was pouring water from the spout of a tea-pot, discharged his urine upon his head. The remedy in this case was resentment and mortification. Cures of patients, who suppose themselves to be glass, may easily be performed by pulling a chair, upon which they are about to sit, from un- der them, and afterwards showing them a large collection of pieces of glass as the fragments of their bodies. An unwillingness to discharge the contents of the bladder, from the cause that has been men- tioned, was once cured by persuading the patient that the world was on fire, and that nothing but his water would extinguish it. This error was cured by Dr. Ferriar by means of an emetic, which, by its action up :m the stomach, destroyed the command of the patient's will over the spinc- ter of the bladder. OF THE MIND. Ill I have heard of a person afflicted with this dis- ease, who supposed himself to be dead, who was instantly cured by a physician proposing to his friends, in his hearing, to open his body, in order to discover the cause of his death. In all the cases that have been mentioned, of error and distress which relate to the body only, similar advantages would probably arise from ex- citing fear or anger, or any other powerful emo- tion of the mind. I attended a young man in the year 1806, who cherished an obstinate hypochondriac belief, a fter his recovery from the autumnal fever, that he should die, and felt at the same time a great dread of death. I assured him over and over that he was in no danger, but without being able to in- spire him with the least expectation of life. In one of my visits to him, I asked him upon enter^ ing his room, how he was ; " very bad," said he, and repeated his belief that he should soon die. His nurse, who sat by him, added, that he had fixed upon an hour in the approaching night as the time for his dissolution, After pausing a few moments, I asked him if I should send a joiner to measure him for his coffin. This question in- stantly gave a new current to his feelings, and from 112 ON THE DISEASES that time he recovered rapidly nor did he evei mention an apprehension of dying to me, in any of my subsequent visits to him. Anger had uni- formly the same beneficial effects upon a gentle- man in Maryland, who, when in health, was ac- customed to speculate upon controverted subjects in religion. There was an opinion held by one sect of christians, which he held in great abhor- rence. His friends, who knew this, always con- trived, when they saw him unusually dejected, to provoke a controversy with him upon the subject that was hateful to him. It never failed to rouse his resentment, and thereby to banish, for a while, a paroxysm of his disease. If debt be the cause of our patient's disease, we may presume it has been incurred with a clear conscience, and a fair character, for a dishonest man seldom feels distress enough from this cause to bring on disease. In this case we must advise our patient to take the benefit of our insolvent and bankrupt laws. Many men have been thus saved from a miserable death, and restored to health, and usefulness to their families and society. If the disease has been induced by the suppo- sed or real ingratitude, neglect, or ill usage of friends or relations there are two modes of treat- OF THE MIND. 113 ing it; one consists in advising forgiveness, or contempt of the injury; the other, in exciting a moderate degree of anger against the persons who have offended or injured our patients. This an- ger, by its stimulus, counteracts the depression both of the body and mind. It should be care- fully guarded from venting itself in acts of malice or revenge. If the disease be induced by nostalgia, or what is called home-sickness, the patient should be ad- vised to visit his native country. It was once cured by this means in a Welch soldier in the British army. When this remedy cannot be em- ployed, it should be opposed, by exciting a pow- erful or active counter passion. In the year 1733 General Praxin led a Russian army to the banks of the Rhine. At this remote distance from their native country, five or six soldiers became unfit for duty every day from home sickness. The Ge- neral issued an order to bury alive all who were affected with it. This punishment was inflicted in two or three instances, in consequence of which the disease instantly disappeared from the army. Fear, excited by a far less cruel remedy, I have no doubt would have had the same effect. p 114 ON THE DISEASES The remedies for this disease, when brought on by disappointed love, and by grief, shall be mentioned, when we come to treat of the cure of the diseases of the passions. It will naturally occur to the reader that the three last causes of hypochondriac madness will be concealed by a patient from the knowledge of a physician. But they must be extorted, by di- rect or indirect means, or the appropriate remedies cannot be employed to remove their hurtful influ- ence upon the system. If the derangement of our patient has been in- duced by the real or supposed distresses of his country, it will be proper to advise him to avoid reading news-papers, and conversing upon political subjects, and thereby to acquire a total ignorance of public events. But if he object to this reme- dy, he should be advised to take a part in the disputes which divide his fellow citizens. In favour of this conduct, 1 shall mention a single fact. There was a form of this disease, well known during the revolutionary war in several of the States by the names of the tory rot, and the protection fever. It was confined exclusively to those friends of Great Britain, and to those timid Americans who took no public part in the war. OF THE MIND. 115 Many of them died of it, but not a single whig nor royalist, who took an active part in the revo- lution, was affected with it. This was the more remarkable, as many of them lost their fortunes and former rank in society, by their exertions in support of the principles and measures to which they had devoted their passions or their lives. By eating garlic, we become insensible of the breath of persons that have been rendered offensive by it. In like manner, by imbibing a portion of party spirit, we become insensible of the vices and fol- lies of our associates in politics, and thus dimi- nish more or less than one half (according to the number of our party) this source of hypochon- driacal derangement. Happily for our citizens, the disease that has been named has passed away with the events of the Ameri n revolution, and from the general operation of the above remedies, as well as from causes formerly mentioned, it has rarely been succeeded by any other form of poli- tical hypochondriasm in the United States. If the disease be derived from a sense of guilt, it is generally connected with ignorance, or erro- neous opinions in religion, i he former must be removed, by advising the visits of a sensible and enlightened clergyman. The latter consist, gene* rally in our patient's believing one or both the 116 ON TUE DISEASES following errors : 1. That he is excluded from the divine mercy by an irreversible decree of the Supreme Being, or, in other words, that he was created on purpose to be made miserable for ever. The second error believed by our patient is, that he has committed the unpardonable sin. To the first error we may reply, that there is no pagan opinion more contrary to nature and reason, and to the whole tenor, as well as to the most con- sistent interpretations, of the Scriptures, than the doctrine of men being called into existence on purpose to endure the pains of eternal misery. To the second error we may reply, that no two divines agree in what constitutes the unpardona. ble sin; that many wise and good men believe it is not possible to commit it, in the present state of the gospel dispensation, and all divines agree that " no man had committed it, who was afraid he had." It is of consequence to a physician, to be fully prepared upon the subjects of the two errors that I have named, for they are the two principal causes of religious hypochondriasm. In the application of all these remedies to the mind, it is of consequence to know that there are acquiescing, reasoning, contradicting, and ridi- culing points in this disease, above which they re- spectively do harm, and below which they are of no efficacy. OF THE MIND. 117 In all cases it will be proper to seduce patients from conversing upon their disease "Conver- sation upon melancholy," says Dr. Johnson," feeds it;" for which reason he advices his friend Bos- well, who was subject to it, " never to speak of it, to his friends, nor in company. There are several other remedies which act up- on the body through the medium of the mind, and that are proper, in this disease from all its causes. The first of these is, the destruction of all old associations of ideas. Every thing a hy- pochondriac patient sees or hears, becomes tinc- tured with some sad idea of his disease. Hence the same objects and sounds never fail of renew- ing the remembrance of it. Change therefore his dress, his room, his habitation, and his company, as often as possible. A gentleman in South Caro- lina used to cure himself of a fit of low spirits by changing his clothes. Even change his per- son as much as possible. Long nails, along beard, and uncombed hair, often become exciting cau- ses of a paroxysm of this disease. The)- should therefore be carefully prevented or removed. 2. Employment, or business of some kind. Man was made to be active. Even in paradise he was employed in the healthy and pleasant ex- 118 ON THE DISEASES ercises or cultivating a garden. Happiness, con- sisting in folded arms, and in pensive contempla- tion, beneath rural shades, and by the side of purl- ing brooks, never had any existence, except in the brains of mad poets, and love-sick girls and boys. Hypochondriac derangement has always kept pace with the inactivity of body and mind which follows wealth and independance in all countries. It is frequently induced by this cause in those citizens, who retire, after a busy life, into the country, without carrying with them a relish for agriculture, gardening, books, or literary society. Building, commerce, a public employment, an executorship to a will; above all, agriculture, have often cured this disease. The last, that is, agriculture, by agitating the passions by alternate hope, fear, and enjovment, and by rendering bodi- ly exercise or labour necessary, is calculated to produce the greatest benefit. Great care should however be taken, never to advise retirement to a part of the country where good society cannot be enjoyed upon easy terms. In those cases in which the body cannot be employed, the mind should be kept constantly busy. Mr. Cowper often relieved his melancholy by reading novels. Hence he has well said, of the mind. 119 " Absence of ocupation is not rest. A mind quite vacant is a mind distj-est." I knew a lady in whom this disease was brought on by a disappointment in love, who cured her- self by translating Telemachus into English verse. The remedy here was, chiefly, constant employ- ment. Dr. Burton, in his Anatomy of Melancholy, de- livers the following direction for its cure : " Be not idle; be not solitary." Dr. Johnson has im- proved this advice by the following commentary upon it. " When you are idle, be not solitary ; and when you are solitary, be not idle." The illus- trious Spinola, upon hearing of the death of a friend, inquired of what disease he died ? " Of having nothing to do," said the person who men- tioned it. " Enough," said Spinola, " to kill a a general." Not only the want of employment, but the want of care, often increases, as well as brings on this disease. This was exemplified in the two instances, formerly mentioned, of suicide being induced by situations in which the heart wished and cared for nothing. Concerts, evening parties, and the society of the ladies, to gentlemen affected with this disease, ISO ON THE diseases have been useful. Of the efficacy of the last, Mr. Green has happily said, " With speech so sweet, so sweet a mein, They excommunicate the spleen." 3. Certain amusements. Those should be perferred, which, while they interest the mind, afford exercise to the body. The chase, shooting, playing at quoits, are all useful for this purpose. The words of the poet, Mr. Green, upon this subject, deserve to be committed to memory by all physicians. " To cure the mind's wrong bias, sfileen, Some recommend the bowling green. Some hilly waljcs—all exercise, Fling but a stone—-trie giant dies." Chess, checkers, cards and even push-pin, should be perferred to idleness, when the weather forbids exercise in the open air. The theatre has often been restorted to, to remove fits of low spirits : and it is a singular fact, that a tragedy oftener dissi- pates them than a comedy. The remedy, though distressing to persons with healthy minds, is like the temperature of cold water to persons benumb- ed with frost; it is exactly proportioned to the excitability of their minds, and it not only ab- QF THE MIND. 121 stracts their attention from themselves but even revives their spirits. A female patient of mine, in whom this disease had several times been excited by family afflic- tions, lost a favourite child in November 1811, which produced many of its symptoms. Soon afterwards her husband became sick. The lighter and dissimilar distress occasioned by this event suddenly removed her disease, and she regained, with the recovery of her husband, her usual health and spirits. Mirth, or even cheerfulness, when employed as remedies in low spirits, are like hot water to a frozen limb. They are disproportion- ed to the excitability of the mind, and, instead of elevating, never fail to increase its depression, or to irritate it. Mr. Cowper could not bear to hear his humorous story of John Gilpin read to him in his paroxysms of this disease. It was to his " heavy heart," what Solomon happily com- pares to the conflict produced by pouring vinegar upon nitre, or in other words, upon an alkaline salt. Certain objects, distinguished for their beauty or grandeur, often afford relief in this disease.. Mr. Cowper experienced a transient elevation of spirits, from contemplating the ocean from the 122 ON THE DISEASES house of his friend Mr. Haley ; and the unfortu- nate Mrs. Robinson soothed the gloom of her mind, by viewing the dashing of the waves of the same sublime object, by the light of the moon, at Brighton. Certain animals suspend the an- guish of mind of this disease by their innocence, ingenuity or sports. Mr. Cowper sometimes, found relief in playing with three tame hares, and in observing a number of leeches to rise and fall in a glass with the changes in the weather. The poet says, " Laugh and be well. Monkeys have been Extreme good doctors for the spleen. And kitte'i-—if the humour hit, Has harliquin'd away the fit." The fsmous Luther was cheered under his fits of low spirits by listening to the prattle, and ob- serving the sports and innocent countenances of young children. The tone of their voices is probably a source of a part of the relief derived from their company. Mr. Cowper was always exhilarated by conversing with Mr. Hay ley's son, only because he was pleased with the soft and musical tones of his voice. 4. Music has often afforded great relief in this disease* Luther, who was sorely afflicted with it, OF THE MIND. 123 has left the following testimony in its favour. " Next to Theology, I give the highest place to music, for thereby all anger is forgotten ; the devil, also melancholy, and many tribulations and evil thoughts are driven away." For the same reason that tragedies afford more relief than comedies, plaintive tunes are more useful than such as are of a sprightly nature. I attended a citizen of Phila- delphia, occasionally, in paroxysms of this disease, who informed me that he was cured of one of them by hearing the old hundred psalm tune sung in a country church. His disease, he said, instantly went off in a stream of tears. Dr. Car- dan always felt a suspension of the anguish of his mind from the same cause ; and Mr. Cowper tells his friend Mr. Hayley, in one of his letters, that he was " relieved as soon as his troubles gushed from his eyes." The tears in these cases acted by indirectly depleting from the brain. It is remarkable, that sprightly tunes are as offensive as comic representations in this disease. This was once exemplified by a Mr. Derberow, formerly a patient in the Pennsylvania Hospital. In a fit of low spirits, he heard the sound of a lively tune from a flute in an adjoining room. He suddenlv rushed into it, snatched the flute from 124 ON THE DISEASES the gentleman's hands who was playing upon it and broke it in pieces upon his head. 5. Committing entertaining passages of prose and verse to memory, and copying manuscripts, have been found useful in relieving hypochon- driasm, They divert and translate attention and action from the understanding to a sound part of the mind. Reading aloud has nearly the same effect. 6. Dr. Burton recommends, in the highest terms, the reading of the bible to hypochondriac patients. He campares in to an apothecary's shop, in which is containd remedies for every disease of the body. I have frequently observed the lan- guor and depression of mind which occur in the evening of life, to be much relieved by the variety of incidents, and the sublime and comfortable passages, that are contained in that only true histo- ry of the origin, nature, duties, and future destiny of man. A Captain Woodward, of Boston, who lately suffered all the hardships of shipwreck on an inhospitable island in the East Indies, found great comfort in revolving the history of Joseph and his brethren in his mind. A captain Ingle- £ field revived his spirits, and those of his crew, in a similar situation, by telling them pleasant stories. OF THE MiIND. 125 The mind requires a succession of connected events to divert it from itself, and this is the reason why stories of all kinds, which require constant attention to comprehend them, are so useful in this disease. Where there is no relish for the simple and in- teresting stories contained in the Bible, the read- ing of novels should be recommended to our pa- tients. They contain a series of supposed events which arrest the attention, and cause the mind to forget itself. It is because they so uniformly pro- duce this effect that they are often resorted to by old people even of elevated understandings, in order to divert themselves from the depression of spirits which the death or treachery of friends, bodily pain, and the dread of futurity, create in their minds. 7. Mentioning the name of a parent, rela- tion or friend, from whom the patient has received acts of kindness, protection, or relief, in early life. We fly from habit to those persons, when in dis- tress in any part of our lives, who have succoured us under the pains and distresses of childhood. These persons are generally our parents. I once assisted in performing the operation of lithotomy upon a young gentleman in this city, whose only 126 ON THE DISEASES cry during the operation was, " O! my father, my father !" I have heard a woman utter the name of her mother only, during the whole time of the ex- cision of a cancerous breast. I attended a young gentleman in our hospital in the year 1803 in this disease, who had lived with a most indulgent grandfather when a boy. In the lowest stage of his depression, the mentioning the name only, of his grandfather revived him, and often drew him into pleasant conversation. The same advantages might probably be derived, from carrying a pa- tient's memory and imagination back to the in- nocent and delightful sports and studies of early life. 8. Matrimony, if our patients are single. The constant pursuits and wholesome cares of a family generally prevent and cure such as are transient and imaginary. 9. Terror, by the concussion it gives to both body and mind, has sometimes cured this disease. A lady in New York, in whom it was induced by the habitual use of opium, was cured by this re- medy, administered by the hand of her physician. In one of his' visits to her, he took a large snuff- box out of his pocket. She looked at it as if she wished for a pinch of snuff. The physician put it OF THE MIND. 127 into her hands. Upon opening it, an artificial snake that had been coiled up in it, suddenly leap- ed upon her shoulder. She was convulsed with terror, and from that time left off the use of opium, and rapidly recovered. She lived forty years after- wards in good health, and finally died about eighty years of age. 10. Travelling. Long journies should be preferred to short excursions from home. They relieve the mind from a monotomy of objects, and awaken a constant succession of new ideas. They moreover create a necessity for constant bodily exertion, and they remove the patient from the society of his friends, who, by being obliged to listen to his complaints, add fuel to his diease. The journies in those cases should be to a warm climate, and the patient should be advised, before he leaves home, to change every article of his dress, even the furniture of his pockets, that he may see nothing while abroad, that can revive his disease by association. In the history of this disease I remarked that there is in hypochondriacs a disposition to inflict pain upon their bodies by means of wounds, in order to suspend anguish of mind. This should 128 . ON THE DISEASES be prevented by removing all the instruments out of their way that are usually employed for that purpose. Sometimes this anguish of mind, I have said, leads its miserable subjects to seek to put an end to their existence by their own hands. This should be prevented, not only by depriving them of all the" means of destroying themselves, but by securing the windows and doors in which they are confined, and never permitting them to be alone ; also by such other means as accident or design have proved to be successful, and which act upon the mind through the medium of the body, and upon the body through the medium of the mind. These are wine, blood-letting, an un- expected sense of pain, compassion, a sudden and violent exertion of the active powers of the body and mind, terror, a sense of shame, and, lastly, infamy. I shall briefly mention instances of the efficacy of each of them in preventing suicide. 1. A gentleman afflicted with this disease went with a loaded pistol into a tavern in London, with a design to destroy himself. To conceal his in- tention, he called for a small decanter of wine, and, after locking the door of the room into which he had been conducted, cocked his pistol, but before he discharged its contents through his OF THE MIND. J.29 head, determined to try the quality of his wine. Perceiving it to be very good, he drank a second, and then a third glass, after which he uncocked his pistol, and finished the whole decanter. Find- ing such a prompt remedy for his despair in this cordial liquor, he continued to use it freely, and was thereby cured. 2. In the year 1803 I visited a young gentle- man in our hospital, who became deranged from remorse of conscience in consequence of killing a friend in a duel. His only cry was for a pistol, that he might put an end to his life. I told him, the firing of a pistol would disturb the patients in the neighbouring cells, and that the wound made by it would probably cover his cell with blood, but that I could take away his life in a more easy and delicate way, by bleeding him to death, from a vein in his arm, and retaining his blood in a large bowl. He consented at once to my proposal. I then requested Dr. Hartshorn, the resident physi- cian and apothecary to the hospital, to tie up his arm, and bleed him to death. The Doctor in- stantly feigned a compliance with this request After losing nearly twenty ounces of blood, he fainted, became calm, and slept soundly the ensu- ing night. The next day when I visited him, he was still unhappy; not from despair and a hatred rf R 130 ON THE DISEASES life, but from the dread of death ; for he now com- plained only, that several persons in the hospital had conspired to kill him. By the continuance of depleting remedies, this error was removed, and he was soon afterwards discharged from the hospital. It will naturally occur to the reader, that this remedy, and the use of wine, should be regulated by a strict attention to the state of the pulse. 3. A maniac in the Pennsylvania Hospital, some years ago, expressed a strong desire to drown himself. Mr. Higgins, the present steward of the hospital, seemed to favour this wish, and pre- pared water for the purpose. The distressed man stripped himself and eagerly jumped into it. Mr. Higgins endeavoured to plunge his head under the water, in order, he said, to hasten his death. The maniac resisted, and declared he would prefer being burnt to death. " You shall be gratified," said Mr. Higgins, and instantly applied a lighted candle to his flesh. " Stop, stop," said he, " I will not die now;" and never afterwards attempt- ed to destroy himself, nor even expressed a wish for death. It has been said that persons who make unsuc- cessful attempts to destroy themselves, seldom OF THE MIND. 131 nepeat them. If this remark be true, I suspect it is only in those cases in which the attempt, like the one above mentioned, has been accompanied with pain, 4. The famous actress Mrs. Bellamy, in an hour of despair, was restrained from suicide by hearing the cry of distress from a child, near a bridge from whence she was preparing to throw herself into the river Thames. 5. Mr. Pinel mentions an instance of a gentle- man who was kept from drowning himself in the same river, by an attempt of two or three ruffians to pick his pocket, and which he defeated by a singular exertion of strength and courage. 6. Zacutus relates the history of a hypochon- driac who had made several unsuccessful attempts to destroy himself by fire. His physician, in or- der to cure him, wrapped him in a fresh sheep- skin, which he had previously wetted with spirit of turpentine. He applied fire to this skin, which instantly enveloped him in a blaze, that so terrified him, that he never attempted afterwards to put an end to his life. 132 ON THE DISEASES 7. Suicide was prevented in the virgins of Mi. letus, among whom it was common from the in* fluence of a new and false opinion in religion, by exposing their naked bodies in a public part of the city. 8. Dr. John Hunter tells us, in his account of the diseases of Jamaica, that the negroes, when they become deranged, sometimes destroy them- selves by eating large quantities of earth. After '♦* many fruitless attempts to put a stop to it, it was finally prevented, by cutting off the heads of the negroes who died in this manner, and exposing them to view in a public part of the Island. Sometimes patients in this state of derange- ment destroy themselves by abstinence from food and drinks. 1 have twice seen death induced in this way in the Pennsylvania Hospital, and once in a private patient. Persuasion and force were alike ineffectual in prevailing upon them to take nourishment. Perhaps some such means as the following might be more effectual for that purpose. 1. In the Memoirs of Count Maurepas, it is related of the same prinee of Bourbon who fancied OF THE MIND. 133 himself to be a plant, that he sometimes supposed himself to be dead, at which time he refused to take any food, for which he said he had no further occasion. To cure this alarming delusion, they contrived to disguise two persons who were intro- duced to him as his grandfather, tnd Marshal Luxemburg, and who, after conversing with him for some time about the shades that inhabited the place of the dead, invited him to dine with Mar- 1 shal Turene. The prince followed them into a cellar prepared for the purpose, where he made a hearty meal, which immediately restored him to a belief that he was alive. A similar case of a man being cured of a belief that he was dead, by being prevailed upon to eat, is related by Dr. Turner, in his Treatise upon the Diseases of the Skin. 2. Mr. Pinel mentions an instance of a man who determined to put an end to his life by ab- stinence from food only, but who continued to drink as usual. His attendants withheld drinks from him until he consented to take food with them. The bodily pain of thirst, in this case, predominated over the anguish of his mind, which had disposed him to seek for death in this mode of suicide. 134 ON THE DISEASES 3. Leaving food in a patient's cell, or room, and carefully avoiding importuning him to eat. The constant sight of food will tend to excite his ap- petite, and a consciousness that he possesses his free agency may induce him to eat, when the most powerful arguments for that purpose would not have that effect. I have heard of a criminal in Scotland who attempted to destroy himself by famine, in whom it was completely prevented by this practice. 4 It is a singular fact in the history of suicide, that it has sometimes been hereditary in families. There are two families in Pennsylvania, in which three of their respective branches have perished by their own hands, in the course of a few years. Similar instances of this issue of family derange- ment are to be met with in other countries. In watching patients so as to prevent their in- juring, or destroying themselves, it is of impor- tance, to know that the paroxysms of despair that prompts to both often comes on suddenly, and is sometimes preceded by unusual tranquility of mind, and even by high spirits. OF THE MIND. 135 CHAPTER IV. Of Amenomania, or the second form of partial Intellectual Derangement. 1 HIS form of madness is a higher grade of hy- pochondriasis, and often succeeds it. It differs from it, 1. In the absence of dyspepsia, or in its cessa- tion, in consequence of the increase of morbid ex- citement in the brain, predominating over that disease in the stomach. » 2. In a difference, or change, of the patient's opi- nions respecting his health, affairs and condition. Instead of supposing himself to be diseased, he now denies that he has any disease ; and instead of feeling, or complaining of misery, he is now hap- py in the errors which accompany his madness. 3. The errors in this form of derangement are more deeply seated than in hypochondriasm. As 136 ON THE DISEASES a proof of this, wc observe, when it arises from love, the sight, or possession of the object beloved relieves or causes it in the latter disease, but it has no effect in the former. I have seen it tried to no purpose in a young gentleman in this city. Dr. Nicholas Robinson mentions an instance, in which even the marriage of a young woman to the man whom she loved was so far from curing her, that she attempted to murder him immediately afterwards. Let it not be supposed that amenomania uni- formly succeeds hypochondriasis. It often pre- cedes it, and they both frequently blend their symptoms together. They likewise alternate with each other. There is moreover, now and then, a mixture of some of the symptoms of hysteria with amenomania, as well as with hypochondriasis. These successive changes and combinations of those forms of disease are to be ascribed to irri- tability or inirritability being different in the sys- tems in which they are seated, and, in some in- stances, to their being different in different parts of the same system. Amenomania is a common form of partial in- sanity. We see it in the enthusiastic votaries of all the pursuits and arts of man. The alchymists, 6F THE MIND. 137 the searchers after perpetual motion, the astrono- mers, the metaphysicians, the politicians, the knight errants, and the travellers, have all in their turns furnished cases of this form of derangement. I once met with a striking instance of it, from aU chymical pursuits, in a gentleman, at the table of Mr. Wolfe, in London. He related the issue of several experiments, in which some of the base metals had been converted into gold, and he de- clared, further, his belief that there was at that time a man living in India, whose life had been pro- longed above 600 years by an elixir that had been discovered by an alchymist. Upon other subjects he was rational and well informed. Dr. Johnson has given a just picture of this disease in the cha- racter of an astronomer, in his Rasselas, prince of Abyssinia. Several of the nations of Europe have lately furnished instances of men deranged, from a belief in the possibility of producing perfection in human nature, and in civil government, by means of what they absurdly called the omnipotence of human reason. But we see this disease of the mind most frequently in the enthusiasts in religion, in whom it discovers itself in a variety of ways; particularly, 1* In a belief that they are the peculiar favour- ites of heaven, and exclusively possessed of just s / 138 ON THE DISEASES opinions of the divine wi 1, as revealed in the Scriptures. 2. That they see and converse with angels, and the departed spirits of their relations and friends. 3. That they are favoured with visions, and the revelation of future events. And, 4. That they are exalted into beings of the highest order. I have seen two instances of per- sons, who believed themselves to be the Messiah, and I have heard of each of the sacred names and offices of the Father, Son, and Holy Ghost, having been assumed at the same time by three persons, under the influence of this partial form of derange- ment, in a hospital in Mexico. There was a time when persons thus deranged were subjected to fines, imprisonment, the extir- pation of their tongues, and even to death from fire and the halter. To the influence of the sci- ence of medicine we are indebted, for teaching that these opinions are generally as devoid of im- piety as an epileptic fit; and for consigning, by that humane discovery, the deluded subjects of them to the cells of a hospital instead of a jail, and to the hand of a physician, instead of the hands of i OF THE MIND. 139 the last officer, of what has improperly been called, criminal justice. In all these cases of partial derangement, the understanding is not only sound upon subjects unconnected with that which produced the disease^ but all the other faculties of the mind are unim- paired ; nor do we observe the subjects of it, as in general madness, to be irritated, or unusually ex- cited, by conversing upon the single and original subject of their disease. It is remarkable that all the errors of amenoma- nia are the reverse of those of tristimania, formerly mentioned, in elevating the patient above his ordi- nary rank and condition of life. The physical remedies for this form of partial derangement are nearly the same as those which have been recommended for tristimania, particu- larly bleeding, purging, emetics, and low diet, in an excited state of the blood-vessels, and, after they are reduced, stimulating diet, drinks and me dicines, and a change of company, pursuits, and climate. The errors which predominate in the mind should be soothed, diverted, or opposed by reasoning or ridicule, according to their force. There is one error, which is sometimes opposed 140 ON THE DISEASES by reasoning with success, and that is, a belief which patients in this pleasant state of derange- ment now and then entertain, that they are favour- ed with extraordinary revelations, and particularly a knowledge of future events. In these cases they should be told, that supernatural knowledge of that kind has generally been revealed to two or more persons at the same time, and that it has always been accompanied with a power of work- ing miracles. Even the Saviour of the world did not rest the credibility of his divine origin, and the objects of his mission, upon his single testi- mony in favour of himself, nor yet upon the su- preme and miraculous power he exercised over spirit and matter; but condescended to receive the testimony of his twelve apostles in favour of the former, and compelled a belief in the latter, by endowing them with a power, similar to his own, over all the operations of nature. Both tristimania and amenomania often continue for months and years, in the form in which they have been described, but they are as often follow- ed by derangement in every part of the under- standing, and in all, or a part of, the other faculties of the mind. When this is the case, it is called general madness, which is the next subject of •ur inquiries and observations. OF THE MINI. 141 CHAPTER V. Of General Intellectual Derangement, ] SHALL divide this general form of derange- ment into three grades or states. I. Mania, by which I mean what has been called tonic madness by some writers, and mania furibunda by Vanswieten. II. Manicula, or madness in a reduced, and most commonly, in a chronic, state. III. Manalgia, or that state of general mad- ness, in which a universal tgrpor takes place in the body and mind. This division of general madness into three states, accords with similar divisions, which have lately been adopted of several other diseases, parti- cularly rheumatism, and inflammation of the liver; 142 ON THE DISEASES The former is known by the names of rheuma- tismus, rheumaticula, and rheumatalgia, and the latter by the names of hepatitis, hepaticula, and hepitalgia. The propriety of thus conforming madness to the divisions of those two diseases will appear when we consider the unity of their proximate cause, and that they all depend upon similar morbid actions in the blood-vessels. Rheu- matism and hepatisis, therefore, may be consider- ed, if I may be allowed the illustration, as mad- ness in the joints, or liver; and madness, as rheu- matism, or hepatitis, in the brain. I. I shall begin with the history and cure of general madness of the first grade, or of what I have called mania. Its premonitory signs are, watchfulness, high or low spirits, great rapidity of thought, and eccentricity in conversation, and conduct; sometimes pathetic expressions of horror, excited by the apprehension of approaching mad- ness ; terrifying or distressing dreams ; a great ir- ritability of temper ; jealousy ; instability in all pur- suits ; unusual acts of extravagance, manifested by the purchases of houses, and certain expensive and unnecessary articles of furniture, and hosti- lity to relations and friends. The face is pale or flushed, the eyes are dull, or wild, the appetite is increased, the bowels are costive, and the pa- OF THE MdND. 143 tient complains sometimes of throbbing in the temples, vertigo, and head-ach. The gentleman formerly mentioned, in whom madness was ex- cited by a number of small shot lodged in his foot, when a school boy was afflicted with deaf- ness. A sudden return of his hearing was always a premonitory sign of an approaching attack of derangement. The remedies in this case should be, 1, The removal of all the remote and exciting causes of the disease, and particularly to abstract the patient from study and business, if they have produced it, and to substitute in their room re- laxation and amusements. Dr. Boerhaave once passed several weeks without sleep, and discover- ed other signs of approaching derangement. He was cured by being torn from his books, and al- lured into agreeable company. 2. Changing the subjects of our patients stu- dies, when they are abstruse and difficult, to such as are of a lighter nature. Rousseau often re- moved, by this means, the premonitory symptoms of madness. The celebrated Mr. M'Laurin, the friend and cotemporary of sir Isaac Newton, made it a practice to relieve his mind, when debilitated 144 ON THE DISEASES by hard study, and thereby predisposed to thife disease, by reading novels and romances; and such was his knowledge of them, that the late Dr. Gregory informed me he was often appealed to for the character of every work of that kind that appeared in the English language. 3. Low diet, and a few gentle doses of purging physic, and, if the pulse be full or tense, the loss often or twelve ounces of blood. By means of these remedies, I have in many instances prevented an attack of madness. The symptoms of this state of derangement, when completely formed, as they appear in the body, are, a wild and ferocious countenance, en- larged and rolling eyes, constant singing, whist- ling or hallooing, imitation of the noises of dif- ferent animals, walking with a quick step, or standing still, often with the hands and eyes ele- vated towards the heavens; wakefulness for whole nights, weeks, months, and, according to Dr. Morely's account of a boy at Naples, for years ; great muscular strength, uncommon adroitness in performing certain acts, and uncommon swiftness in running. The nerves are insensible to cold, heat, and to irritants of all kinds. I am aware that insensibility to cold is denied by Mr. Hal- OF THE MIND. 145 flwl Jj&>pl%, who have attempted to destroy them- selves by cutting their throats, or otherwise open-1^' ing large blood-vessels, have been cured by the profuse haemorrhages which have succeeded those acts. Of this, several instances have occurred with- in my know ledge. 6. By the morbid appearances of the blood which has been drawn for the cure of this form of madness. It is generally diseased beyond that grade in which it exhibits a buffy coat. Of 200 patients bled by Mr. Halsam, in the Bethlehem Hospital, the blood was sizy in but six cases, and from the cause that has been assigned. I have seen nearly all the morbid appearances of the blood which I have enumerated in my defence of blood -letting, and never a single instance in which it put on a natural appearance, 7. Blood-letting is indicated by the extraordi- nary success which has attended its artificial use OF THE MIND. 187 in the United States, and particularly in the Penn- sylvania Hospital. In the use of bleeding in this state of madness, the following rules should be observed : 1. It should be copious on* the •first attack of the disease. From 20 to 40 ounces of blood may be taken at once, unless fainting be induced before that quantity be drawn. It will do most service if the patient be bled in a standing pos- ture. The effects of this early and copious bleeding are wonderful in calming mad people. It often prevents the necessity of using any other remedy, and sometimes it cures in a few hours. 2. It should be continued not only while any of those states of morbid action in the pulse re main which require bleeding in other diseases, but in the absence of them all, provided great wake- fulness, redness in the eyes, a ferocious coun- tenance, and noisy and refractory behaviour con- tinue, all of which indicate a highly morbid state of the brain. We bleed in the same natural state of the pulse in the pneumonia notha. We do the same thing in a similar form of hepatitis 188 ON 1"HE DISEASES The propriety of bleeding in this mania notha, il I may be allowed to use a term founded upon the Unity of its cause (that is, congestion of blood without inflammation) with the causes of the above diseases of the lungs and liver, has often been demonstrated in the Pennsylvania Hospital. Its advantages, I* well recollect, attracted the attention of the pupils of the hospital in the year 1805, in a more than ordinary manner, in the case of a man of the name of Pickins. His madness was recent, his skin was cool, and his pulse natu- ral, but his eyes suffused with blood, and he was unable to sleep. I bled him copiously, after which his pulse became frequent and tense. I repeat- ed the bleeding, and gave him several doses of purging physic, which cured him in a few days 3. It should be more copious in phrenimania and synochomania, than in simple madness. Its liberal use is particularly indicated in the latter, when it is formed by the union of madness with pregnancy, or with the autumnal or puerpe- ral fever, in all which the blood-vessels labour under disease in other parts of the body, as well as the brain. i 4 It should be less copious in madness from drunkenness, than from any of its other causes, OF THE MIND. 189 all the circumstances that call for it being equal. For the reasons for this caution, the reader will please to consult the defence of blood-letting, in the third volume of the author's Medical Inquiries and Observations. 5. It is indicated no less in the seventh and eighth forms of general mania, formerly described, than in those which preceded them. I think I once prevented suicide by it, in a young gentle- man descended from a family in which several of its members had perished by their own hands. 6. The quantity of blood drawn should be greater than in any other organic disease. This is indicated not only by most of the reasons for bleeding formerly given, but by the strong and uncommon hold which the disease takes of the brain. Many circumstances prove this to be the case, but none more than its not being cured, and scarcely suspended, by the acute and painful dis- ease of parturition, several instances of which have come under my notice. From among many cases of the successful issue of profuse bleeding in this form of madness, I shall select but two : the former was in Mr. T. H. of the state of New Jersey, a man of sixty-eight years of age, from whom I drew nearly 200 ounces of blood, between the 190 ON THE DISEASES 20th of December and the 14th of February in the year 1807: the latter was in Mr. D. T. of the state of New York, who lost about 470 ounces, by my order, by 47 bleedings, between the months of June 1810, and April 1811. Both these gen- tlemen were my private patients in the Pennsyl- vania Hospital. Were it necessary I could add to these cases several others, communicated to me by my pupils, particularly by Dr. Wallace, of Virginia, and Dr. Anan, of Maryland, in which a similar practice had been attended with the same success. After all the symptoms which call for blood- letting have disappeared, we sometimes observe the disease to continue. In this case morbid ex- citement becomes insolated, but still so considera- ble as not to yield to purges or blisters. Here cupping is indicated. The cups should be ap- plied to the temples, behind the ears, and to the nape of the neck. Leeches may be used for the same purpose, and to the 'same places. They may likewise be applied to the haemorrhoidal ves- sels with advantage, in persons who have been subject to the piles. The sympathy of the brain with these vessels is so intimate, that the disease yields as readily to the loss of blood from them, » OF THE MIND. 191 as from the parts that have been mentioned near the brain. Arteriotomy performed upon the temporal arte- ry, it is said, is more useful than venesection, or local bleeding with cups and leeches. I can say nothing in its favour from my own experience. I have only to add to these remarks upon the use of cups and leeches, that they are not only useless, but often hurtful, if applied before the ac- tion of the pulse is reduced. By inducing de- bility in the blood-vessels of the brain, they invite morbid excitement to it from the blood-vessels of the trunk and extremities of the body, provided they retain a predominance, or even an equality of action with the blood-vessels of the brain. 3. Solitude is indispensably necessary in this state of madness. The passions become weak by the abstraction of company, and by refraining from conversation. For this reason visitors should be excluded from the cells and apartments of highly deranged people, and there are times in which the visits of a physician, and of the cell-keeper or nurse, should be as seldom and short as are con- sistent with the proper treatment and care of the patient. 192 ON THE DISEASES 4. Darkness should accompany solitude in the first stage of this disease. It invites to silence, and it induces a reduction of the pulse, by the abstraction of the stimulus of light, and by the influence of fear which is naturally connected with darkness. There are four cells in the Pennsylva- nia Hospital, so formed that it is possible to ren- der them dark with but little trouble. 1 have seen the happiest effects from confining noisy patients in them. 5. An erect position of the body. There is i a method of taming refractory horses in England, by first impounding them, as it is called, and then keeping them from lying down or sleeping, by thrusting sharp pointed nails into their bodies for ' two or three days and nights. The same advan- tages, I have no doubt, might be derived from keeping madmen in a standing posture, and awake, ' for four, and twenty hours, but by different and more lenient means. Besides producing several of the effects of the tranquillizing chair, it would tend to reduce excitement by the expenditure of excitability, from the constant exertion of the ^ muscles which support the body. The debility thus induced in those muscles would attract mor- bid excrement irom the brain and thereby re- j lieve the disease. That benefit would arise from OF THE MIND. 193 preventing sleep, I infer from its alutarys effects in preventing delirium, and from delirium being always increased by it in fevers of great morbid excitement. 6. Low diet, consisting wholly of vegetables, and those of the least nutritious nature. What would be the effect of fasting for two or three days in this state of madness? I am dispo- sed to think favourably of it, from a fact com- municated to me by a gentleman who resided twenty years in the interior parts of India. He informed me that the wild elephants, when taken, are always tamed by depriving them of food, un- til they discover signs of great emaciation. They are then fed with mild aliment, and soon acquire their usual flesh, but without the least return of their ferocity. Fasting is calculated to act in two ways, in the cure of tonic madness: 1, by lessening the quantity of blood by the abstraction of aliment; and 2, by exciting the disease of hunger in the stomach to such a degree, as to ena- ble it to predominate over the disease of the brain, and by that means attract it to a less vital part of the body. The effects of this severe remedy in curing inflammatory dropsy, render it still more probable that it might be employed, with advan- tage, in this disease of the brain. Against its use b b 194 ON THE DISEASES it may be said that the ferocity of certain wild animals is increased by hunger; this is true, but ferocity is not derangement. It is possible it might exist for a little while, and be attended with symptoms totally different from those which lake place in madness, and of a nature that would yield more easily to the power of medicine. The drinks of a patient in this state of madness should be of the most simple kinds. 7. Purging, Cremor tartar, salts, senna, calomel and jalap, have all been employed for this purpose. Their use is indicated by the obstruc- tions in the viscera, and torpor of the alimentary , ( canal, which generally accompany this form of madness. There are cases in which the purges should be given daily, so as to excite an artificial diarrhoea. Nature, as I shall say presently, some- times cures madness in this way. It is much in favour of this chronic mode of purging, that L w persons are ever delirious in their last moments, who die of discharges from their bowels. In the mixture, which sometimes takes place, of mania with the synochus form of bilious fever, purging should be employed more freely than in simple madness. Calomel and jalap should be preferred for that purpose. OF THE MIND. 155 8. Emetics are spoken of very differently by authors. Some commend, while others condemn, them. When they have done harm, it must have been by giving them before, or after, the system was reduced below the emetic point. When giv- en at that point, they have done good in many cases. I mentioned formerly their manner of operating, in treating of their efficacy in partial de- rangement, 9. Nitre has done the same service in this disease, that it has done in other diseases, which af- fect the blood-vessels. Its efficacy is increased by such additions of tartarized antimony and ca- lomel to it, as shall increase its disposition to act upon the bowels and skin. 10. Blisters, like emetics, have been con- sidered as remedies of doubtful efficacy; but it is only because they have not been employed in the manner, or at the precise time, that was necessary to obtain benefit from them. In a letter which I received in the year 1794, from Dr. Willis, senr. he informed me that he always applied them to the ancles in this disease, instead of the head or neck. He gave no reason for this practice, but it imme- diately suggested a principle to me, from which I have derived great advantages, not only in the 196 ON THE DISEASES treatment of madness, but of several other diseases. In the first stage of tonic, or violent, madness, the disease is intrenched, as it were, in the brain. It must be loosened, or weakened, by depleting remedies, before it can be dislodged, or transla- ted to another part of the body. WThen this has been effected, blisters easily attract it to the lower limbs, and thus often convey it at once out of the body. The same reasoning applies, with equal force, and the same practice with equal success, to all the violent diseases of the breast and bowels. The blisters do the same service, when appliedrto the wrists, and still more, when applied at the same time, or alternately, to both extremities. After the complete reduction of the pulse, they may be applied with advantage to the neck and head. 11. Cold, in the form of air, water and ice. The cold air should be applied both partially and generally. To favour its partial action, the hair should be cut off, and shaved from every part of the head. Dr. Moreau, a French physician, has related a cure of madness performed by this sim- ple remedy alone. How far the hair, by its sym- pathy with the brain, which it discovers by pre- ternatural dryness in the forming state of many diseases, and by the alteration in its figure, co- OF THE MIND. 197 lour, and quantity, from the influence of certain emotions and passions of the mind, may increase this disease, we know not; but we are certain, by cutting off, we not only expose the head to a greater degree of cold, but we favour by it, at the same time, depletion from the brain, by means of insensible perspiration*; for, however strange it may appear, there is a grade of action in the per- spiring vessels, in which their discharges are in- creased by the sedative operation of cold. Cold air, by its action upon the whole body. has likewise done service in this state of mad- ness. I have heard of two instances, in which it was cured by the patients escaping from their keepers in the evening, and passing a night in the open air in the middle of winter. One of them relapsed ; in the other the cure was permanent. Cold water should be applied in like manner to the head, and the whole body. To the former it should be applied by means of cloths, or a blad- der, to which ice, when it can be obtained, should be added ; for the head, from its greater insensi- bility % cold than any other part of the body, feels, in but a feeble degree, the coldness of sim- ple water. I have found this to be a more effec- tual, as well as a more delicate, mode of applying 193 ON THE DISEASES cold to the head, than by means of the clay cap, as advised by Dr. Cullen. The water, or ice, should be frequently renewed, and they should be continued for several days and nights. The sig- nal for removing them should be, when they pro- duce chilliness, and sobbing or weeping in the patient. The advantages of these cold applica- tions to the head will be much increased, by pla- cing the feet at the same time in warm water. The circulation is thereby more promptly equalized. The reader will find a striking instance of the efli. cacy of using cold and warm water in this man- ner to the two extremities, by my advice, in a case of mania published by Dr. Spence, of Dumfries, in Virginia, in Dr. Cox's Medical Museum. In order to derive benefit from the application of cold water to the whole body, it should be im- mersed in it for several hours, by which means we prevent the reaction of the system, and thus render the sedative effects of the water perma- nent. Pumping for an hour or two upon a pa- tient acts -in the same way; but as it has some- times been employed in curing a fit of drunken- ness, and may be considered as a punfghgient, rather than a remedy, immersion of the body should be preferred to it. The patience and in- sensibility of the system to cold, in this state of OF THE MIND. 199 tlie system is illustrated by a striking fact, men- tioned by Dr. Currie in his Medical Reports. He. tells us, a deranged young woman slept upon a cold floor during a whole night, so cold as to freeze water and milk upon her cable, without suf- fering the least inconvenience from it. 11. A salivation. I mentioned the manner in which this remedy operated upon the brain, the bowels, and the mind, in treating of the cure of hypochondriac derangement. Too much cannot be said in its favour in general madness. I once advised it in a case of this disease from parturi- tion, in which the patient conceived an aver- sion from the infant that had been the cause of her suffering. On the day she felt the mercury in her mouth, she asked for her infant, and press- ed it to her bosom. From that time she rapidly recovered. It is sometimes difficult to prevail upon patients in this state of madness, or even to compel them, to take mercury in any of the ways in which it is usually administered. In these cases I have suc- ceeded, by sprinkling a few grains of calomel daily upon a piece of bread, and afterwards spreading over it a thin covering of butter. 200 ON THE DISEASES 12. The Peruvian bark. In all those ca- ses in which mania is complicated with the in- termitting fever, or with those prostrate states of fever, in which bark is usually administered, this medicine may be given with advantage. I have thus enumerated the principal remedies, which have been employed in reducing the pre- ternatural excitement of the system which takes place in tonic madness. There are some others which have been employed for the same purpose, upon which I shall make a few remarks. 12. Opium. From an erroneous belief in the supposed sedative power of this medicine, it has been prescribed in this state of derangement, but I believe always with bad effects. When given in small doses, so as to prevent sleep, and by that means gradually to waste the excitability, or what Dr. Darwin calls the sensorial power of the sys- tem, it may be useful. 14. Digitalis. I have occasionally adminis- tered this medicine in tonic madness, but never with any radical or permanent success. 15. Camphor has been supposed to pos- sess specific virtues in this state of madness. I OF THE MIND. 201 have often prescribed it when a young practitioner, but without any obvious advantage. I should feel some hesitation in bearing a testimony against this, and the preceding medicine, had I not lately discovered that my experience of their inefficacy in this disease, accords with that of the ingenious Dr. Ferriar. They have both derived their cerdit in madness from their lessening the frequency 0 of the pulse, in which, disease has very improper- ly been supposed to consist. But the frequency of a pulse may be lessened, without a reduction of its force, and even both may be effected by these medicines upon the pulse on the wrist, and yet ir- regular action in the blood-vessels of the brain, which constitutes the disease, still continue, and until this be removed, they are calculated to do harm, by inducing obstruction in the brain, and thereby perpetuating the disease When madness arises from drunkenness, those medicines are safer and more useful, than when it arises from those causes which require copious blood-letting. In addition to them, volatile salts, bitters, and small quantities of ardent spirits, may be given with advantage, provided the system be first moderately reduced by the use of depleting re- medies. c c 202 ON THE DISEASES I suspect many, and perhaps all, the cures that have been performed by opium, digitalis, and cam- phor, have been of madness from the intemperate use of strong drink. The disease in most of these cases partakes of the nature of a soap bubble. With all its apparent force, it is both feeble, and transient, and not only bears stimulants with safe- ty, but sometimes requires them immediately after gentle evacuations of any kind. 16. Hellebore has been famed, for many centuries, as a specific for madness. It is gene- rally admitted that it is useful, only, when it acts as a purge. 17. Dr. Gregory, senr. used to relate, in his lectures, a method of curing tonic madness, which was practised by a farmer in the neighbourhood of Aberdeen, in Scotland. It consisted in yoking a number of madmen in a plough, and compelling them, by fear or force, to plough his fields. This remedy acted, by reducing and expending the morbid excitement of the system. Refractory domestic animals are sometimes subdued in the same way ; but experience has taught us that they may be tamed by more gentle means. Ex- perience has proved, in like manner, that the system in tonic madness may be ruduced by remedies that offer less violence to huma- OF THE MIND. 203 nity, and that do not add to the affliction of the disease, by degrading the patient to a level with our domestic animals. 18. As soon as the disease shows signs of abatement, the patient should be relieved from his confinement, in order to partake of the bene- fits of fresh air and exercise. Swinging, riding in a carriage, and moderate walking, will be high- ly proper in this state of his disease. To these should be added, 19. The shower bath. Thisrexcellent reme- dy acts upon the head, by the stimulus arising from the weight and momentum of the water, and by the reaction of the blood-vessels after the sedative effects of the water are over. I have seen very happy results from it. To do much service, it should be used two or three times a day. _0. The diet and drinks of the patient should now be of a cordial nature ; and where obstinate wakefulness or restlessness attends, opium may be given at bed-time with safety and advantage. 21. When the disease affects the nervous and muscular systems, in common with the blood-ves- sels, with hyst'-in'.al orcon vulsive symptoms ; as- safcetida, ca^o/, and the oil of amber, should be 204 ON THE DISEASES given with all the remedies that have been men- tioned. II. We come next to mention the remedies that are proper to act upon the body through the medium of the mind. 1. The first remedy under this head is to divert the ruling passion or subject which oc- cupies the mind, if it be one, and fix it upon some other. Nothing effectual can be done without great attention to this direction. The author has endeavoured to show, in an inquiry into the influence of physical causes upon morals, how much the possions may be made to neutral- ize and decompose each other, and thus to lessen their influence upon the body. History furnishes several examples of the truth of this remark. I mentioned formerly the effects of opposing the fear of shame to a false opinion in religion, in pre- venting suicide in the virgins of Miletus. Achil- les was diverted by his mother Thety s from gratify- ing his revenge upon the body of Hector, by sup- planting that baneful passiou by the passion of love. Anger, and even rage, have often been op- posed with succes by terror and fear, and delibe- rate malice by a delicate stroke of wit. Where OF THE MIND. 205 the mind is deranged upon all subjects, we should endeavoured to fix it upon but one. In order to do this, it will be necessary to find out the favourite studies and amusements of our patients. The late Dr. Ash, Dr. Priestly informed me, was cured of derangement upon a variety of sub- jects, by seducing him to the study of mathema- tics, of which he had been fond in early life. The distracted mind of the poet Cowper was composed, while he was employed in the single business of translating Homer; and I have heard of a wo- man who was cured of madness, by keeping her constantly employed for several days in play- ing cards, to which it was known she had always had a strong attachment. There are few persons so much deranged, as not to exhibit, for a half an hour or more, marks of correctness of mind, when drawn into conversation upon some subject not connected with their derangement. I admit that this diversion of the passions and understanding cannot be effected, where the whole mind, and all the passions, are under the influence of mad- ness. Thus the virgins of Miletus could not have been cured by an appeal to the female sense of shame, had their moral faculties partaken of the dis- ease of their other passions ; nor could Dr. Ash have been cured of his intellectual derangement by 206 ON THE DISEASES by the study of mathematics, had he lost all his re- collection of quantity and numbers. 2.^A sudden sense of the absurdity, folly, or cruelty of certain actions, produced by con- versation, has sometimes cured madness. The cure in this case bears a resemblance to the sud- den reduction of a dislocated bone. Some years ago a maniac made several attempts to set fire to our hospital. Upon being remonstrated with, by Mr. Coats, one of its managers, he said, " I am a sal- amander ;" " but recollect (said Mr. Coats) all the patients in the hospital are not salamanders;" that is true, said the maniac, and never afterwards attempted to burn the hospital. Many similar instances of a transient return of reason, and some of eures, by pertinent and well directed conver- sations, are to be met with in the records of medi- cine. 3. Madness has sometimes been cured by the influence of place, time, and company, upon the human mind. In favour of the benefits of as- sociation from place I shall mention the following facts. Van Swieten relates a story of a cabinet- maker, who always recovered his reason as soon as he entered his work-shop. A certain Mrs. D----, of this city, formerly a patient of mine, on OF THE MIND. 207 the 27th of March 1792, was suddenly seized with derangement on her way from market. She rambled for two hours up and down the city, and at length was conducted to her own house. The moment she looked around her, she recovered her reason, nor did she relapse afterwards. I have known one clergyman, and have heard of another, who were deranged at all times, except when they ascended the pulpit, in which place they discover- ed in their prayers and sermons, all the usual marks jof sound and correct mind. I once attend- ed a judge, from a neighbouring state, who was rational and sensible upoft the bench, but con- stantly insane when off it. Time by its influence upon a deranged mind, sometimes produces heal- thy and regular associations of ideas and conduct. The late Rev. Dr. ----, of Baltimore, was ob- served to be less deranged on Saturdays, than on any other day of the week, probably from that day being formerly devoted exclusively to retirement and study, in preparing for the exercises of the ensuirtg Sabbath. Company has a similar effect in restoring healthy and regular associations in the mind. It should always be of that kind which produced respect in former times. It will readily occur to the reader, that all these remedies, deri- ved from association, will be proper only in the de- clining and moderate state of the disease. 208 ON THE DISEASES 4. Great care should be taken by a physician, to suit his conversation to the different and vary- ing states of the minds of his patients in this dis- ease. In its furious state, they should never be contradicted, however absurd their opinions and assertions may be, nor should we deny their re- quests by our answers, when it is improper to grant them. In the second grade of this disease we should divert them from the subjects upon which they are deranged, and introduce, as if it were ac- cidentally, subjects of another, and of an agreea- able, nature. When they are upon the recovery, we may oppose their opinions and incoherent tales by reasoning, contradiction, and even ridicule. I attended a lady some years ago in our hospital, in whom this practice succeeded to my wishes. Jn the first and raving state of her disease, she said the spirit of general Washington visited and conversed with her every night. I took no notice of this assertion, but prescribed only for the ex- cited state of her pulse. After this was reduced, I entered into conversation with her, and instantly obtruded a subject foreign to the nightly visits of the spirit of general Washington, whenever she mentioned it. One day, when she appeared ra- tional upon all the subjects upon which we con- versed, she lifted up the skirt of her silk gown, and said, " See what a present general Washing- OF THE MIND. 209 ton made me last night!" O! fie ! said I, Madam, I thought you had more understanding than to suppose general Washington would leave his pre- sent abode, to bring a silk gown to any lady upon the face of the earth. She laughed at this rebuke, and never mentioned the name of general Wash- ington to me afterwards, nor discovered any other mark of the remains of her disease. From the history of this case, we see there are the same acquiescing, divertino;, and opposing points in this grade of madness, that were men- tioned in treating upon the cure of tristimania, and amenomania, all of which should be carefully at- tended to in conversing with persons who are af- fected with it. We see further from this case, that the cure of mental and bodilv diseases is to be effected by the same means. We first reduce the system, then create revulsive actions, and finally remove sub- sequent debility, or feeble morbid actions, by stimulating remedies. From the nature of the last of these remedies, the necessity of rescuing maniacal patients from solitude must be verv ob- vious in order *o their producing a salutary effect. Indeed they should never be confined a day after Dd 210 ON THE DISEASES they cease to be disposed to injure themselves or others. 5. The return of regularity and order in the operations of the mind will be much aided, by obliging mad people to read with an audible voice, to copy manuscripts, and to commit interesting passages from books to memory. By means of the first, their attention will be more intensely fixed upon one subject than by conversation. In this way only, they read when alone, and in this way only, they comprehend what they read. They revert in this respect to the state of childhood. By copying manuscripts, the attention will be still more fixed to one subject, and abstracted from all others. I have witnessed the most salu- tary effects from it, particularly in a gentleman from New England, whose cure was completed by transcribing a volume of lectures for a student of medicine. Committing select passages from books to memory will be more useful than either of them, inasmuch as it requires greater efforts of mind to accomplish it. To facilitate this mode of exciting and regulating the faculties and opera- tions of the mind, a few entertaining books of history, travels and prints, should compose a part of the shop furniture of every public and private mad-house. OF THE MIND. 211 6. Music has been much commended in this state of madness. History records two cures of royul patients being affected by it. Dr. Cox men- tions a striking instance of its power over the mind of a madman. It should be accommodated to the state of the disease. In that grade of it which is now under consideration, the tunes should be of a plaintive, that is, of a sedative nature. 7. Terror acts powerfully upon the body, through the medium of the mind, and should be employed in the cure of madness. I once advi- sed gentle exercise upon horseback, in the case of a lady in Virginia who was deranged. In one of her excursions from home, her horse ran away with her. He was stopped after a while by a gate. The lady dismounted, and when her at- tendants came up to her, they found her, to their great surprise and joy, perfectly restored to her reason, nor has she had since, the least sign of a return of her disease. A fall down a steep ridge cured a mania of twenty years continuance. Dr. Joseph Cox relates three cures of madness by nearly similar means. Dr. M. Smith, of Georgia, inform- ed me, that a madman had been suddenly cured in Virginia, by the breaking of a rope, by which he had been let down into a well that was employed as a substitute for a bathing tub. He was nearly drown- 212 ON THE DISEASES ed before he was taken out. The cures in all these cases were effected, by the new acdons induced in the brain by the powerful stimulant that has been mentioned. In the use of it, great care will be necessary to suit its force to the existing state of the system. 8. Fear, accompanied with pain, and a sense of shame, has sometimes cured this disease. Banhoiin speaks in high terms of what he calls " flagellation" in certain diseases. I have heard of several instances of its efficacy in tonic mad- ness. Two soldiers were cured by it in the American army, during the revolutionary war. A madman, who escaped from his keepers in Mary- land, ran to one of his neighbours with an in- tention to kill him. His neighbour met him with a heavy whip, and beat him until he fell upon his knees, and implejred him to spare his life. He rose from his knees in a sound state of mind, and had no symtom of his disease afterwards. In mentioning the cures performed by the whip, let it not be supposed that I am recommending it in this state of madness. Fear, pain, and a sense of shame, may be excited in many other ways, that shall not leave upon the memory of the patient the distressing recollection, that he owes his recovery o such a degrading remedy. OF THE MINB. 213 9. How far artificial grief might be employed with advantage in this disease, I shall not deter- mine, but I have heard of its having been sus- pended for several days, in a clergyman now in the Pennsylvania Hospital, by the death of one of his children ; and of mania of five years standing, descending to manalgia, in a lady in New York, by hearing of the death of her husband. It caused her to weep for several weeks, The disease in this case, which had been diftused through all her passions, was suddenly concentrated in but one of them, and in her understanding, from whence it gradually passed out of her sjstem. If these facts should not be deemed a sufficient warrant to cre- ate artificial grief, they will show that relief may be expected, from communicating to persons af- fected with this grade of madness the intelligence of the death of their relations and friends. 10. Convalescents from derangement should be defended from the terrifying or distressing noises of patients in the raving state of this dis- ease, by removing the latter to small lodges, re- mote from the hospital, or private mad-houses, or by confining them in cells that are made with double walls, doors, and windows, so as to ob- struct the passage of sound. A relapse has often been induced by the neglect of this caution. 214 ON THE DISEASES CHAPTER VII. II. Of Manicula. XHIS second grade of general madness, which I have called manicula differs from mania, as chronic rheumatism differs from that which is acute, that is, in being accompanied with a more moderate degree of the same symptoms. The pulse is usually synocula, typhoid or typhus. It is in this state of madness that we discover that peculiar sensibility to cold, which is generally ab- sent in its highest and lowest grades. Shaks- peare, who saw this disease in common life, and out of the restraints and conveniences of a hospi- tal, has very happily illustrated this symptom in the character of Edgar, whom he often makes to exclaim in, counterfeiting madness, " poor Tom's a cold," From the operations of fresh exciting causes, manicula now and then rises into mania, in which state it is sometimes cured, but it of. tener descends in a few days or weeks to its chro- nic, or habitual form. It is now and then com- OF THE MIND. 215 bined with typhus fever, in which state it has been called b) Dr. Cullen typhomania. We see it oc- casionally in the last stage of the puerperal, the jail, and autumnal fever. The remedies for this grade of madness should be the same in its inflammatory state as for ma- nia, but of less force. In its typhoid and typhus states, they should be the same as in the declining state of mania, with the addition of garlic in sub- stance or infusion, and the different preparations of iron. In the typhomania, the remedies should be combined with those usually employed in the treatment of typhus fever, particularly bark and opium. The latter is an invaluable medicine in such cases. The dose of it should be much lar- ger than in common diseases of the same grade of action. 216 ON THE DISEASES CHAPTER VIII. III. Of Manalgia. THE symptoms of this third and last form of ge- neral madness are, taciturnity, downcast looks, a total neglect of dress and person, long nails and beard, dishevelled or matted hair, indifference to all surrounding objects, insensibility to heat and cold. A remarkable instance of insensibility to the I iter occurred in a certain Thomas Perrin, who was admitted into the Pennsylvania Hospital, with manalgia, in March 1765, and who died there in September 1774, during all which time he ate and slept in the cupola of the hospital, and never, in the coldest weather of nine winters, came near to a fire. A fixed position of the body sometimes at- tends this form of madness. Of this there have been two rem.rkahle instances in our hospi- tal. In one of them, the patient sat with his body bent forward for three years without moving, except when compelled by force, or OF THE MIND. 217 / the calls of nature. In the other, the patient ac- cupied a spot in a ward, an entry, or in the hospi- tal yard, where he appeared more like a statue than a man. Such was the torpor of his nervous system, that a degree of cold, so intense as to produce inflammation and gangrene upon his face and limbs, did not move him from the stand he had taken in the open air. ', he cause of this young man's insanity was as singular as its nature. It was induced by his father's selling a pleasant farm, upon the Delaware, in the neighbourhood of Philadelphia, on which he was born, and had pass- ed his youth, and which he expected to inherit af- ter the death of his father. The skin in manalgia is dry, cold, pale, yellow, brown, livid, and dark coloured and now and then covered here and there with black spots. The eyes, when originally dark, acquire a light colour in this disease I took no- tice formerly of the prevalence of this colour in the deranged patients in the Pennsylvania Hospi- tal. It probably arises from the tendency of the system to dissolution, for we frequently see it in the last stage of pulmonary consumption, and it rarely fails to take place in old age. The appe- tite in manalgia is inordinate or weak, the bowels are costive, the urine is scanty in quantity, and there is sometimes a discharge or slabbering of saliva. This symptom with one other, was select- e e 218 ON THE DISEASES ed by David, when he counterfeited madness in order to prevent the discovery of his per- son by the king of Gath, after his escape from the hands of Saul. "And he changed his behaviour before them (says the sacred historian) and feign- ed himself mad, and scrabbled upon the doors of the gate, and let his spittle fall down upon his beard." The discharge of saliva in this case ap- peared to be involuntary, and in this we perceive a distinguishing mark between manalgia and tonic madness, in the latter of which, I said for- merly, the saliva is discharged with difficulty by spitting. The respiration is slow, the breath and perspiration, have a peculiar and offensive smell and the pulse is languid and frequent, but some- times natural. Nebuchadnezzar seems to have been affected with this low grade of madness. He was said to resemble a beast, probably from the uncommon growth of his hair, beard, and nails. A strong attachment to tobacco is common in the patients who have been previously in the habit of using it. They frequently abk strangers for it, or a few cents to buy it. These are the usual symptoms of manalgia in hospitals, but when persons who are affected with OF THE MIND. 219 it posses their liberty, they rather seek for, than shun human society. They are often admitted by private families to pass nights in their kitch- ens, garrets, or barns. Sometimes they wander through neighbourhoods in the capacity of beg- gars. Shakspeare has described this state of de- rangement, very accurately, in the character of Edgar, in King Lear, when he makes him adopt the resolution of counterfeiting the character of a madman. " I will (says Edgar) take the basest and poorest shape, That ever penury, in con empt of man, Brought near to beast. My lace I'll grime with filth. Blanket my loins, tie all my hair with knots, And, with presented nakedness, out-face The winds, and persecutions of the sky : And with this horrible object, from low farms, Poor pelting villagers, sheep cotes, and mills, ' Sometimes with lunatic bans, sometimes with prayers, Enforce their charrity." There are some instances in which the moral faculties are impaired in manalgic patients, in which case they are mischievous and vicious, but they are more generally inoffensive, and disposed to be kind, and even useful, in hospitals and fa- milies. In some of them, the sense of Deity is not only unimpaired, but in an elevated state. The mad poet, Christopher Smart, often kneel. 220 ON THE DISEASES ed down and prayed in the streets of London, when he was permitted to leave his house, and he never suffered any of his visitors to leave him, Avithout requesting them to pray with him. A late poet has described this pious form of manalgia, in a young woman, very happily in the following lines : " But her praise was still, to be "Where holy congregations bow. Wrapt in wild transports, while they sang; And when they pray'd, would bow her low." Madness in this form sometimes continues for ten, fifteen, twenty, and even fifty years, when not accompanied with paroxysms, but it more generally terminates in death in a shorter time, and frequently by diseases, to be mentioned here- after. The equanimity of temper, together with the want of exercise, and the inordinate appetite, which generally accompany this disease, sometimes pro- duce obesity. They had that effect, Dr. Johnson tells us, upon Mr. Smart. I have seen two in- stances of it in Pliladelphia. OF THE MIND. 221 The REMEDIES for MANALGIA should COU- sist, like those under a former head, of such as act, I. Upon the mind, through the medium of the body;and, II. Upon the body, through the medium of the mind. I. To the first head belong, 1. Cordial food and drinks. The former should be made savoury and grateful to the taste, and the stimulus from the pleasure imparted by it should be increased by its variety. The latter should consist of wine, cyder and malt liquors. Ardent spirits should be given with great caution, lest a destructive fondness should be acquired for them. There is least danger of this being the case, when they are given in an undiluted state once or twice a week. I have seen the most beneficial effects from them, when administered in this manner. To patients in whom this form of madness has been induced by intemperance in drinking, they may be given daily, and in liberal quantities. 222 ON THE DISEASES 2. The warm bath. The water should be heated above the natural temperature of the body, in which state it acts powerfully upon the arterial system. I have once known it induce 150 strokes in the pulse in a minute, and excite the brain into delirium, in an experiment made u; on himself by a student of medicine in the university of Penn- sylvania. From the occasional effects of fevers, which act in a similar way upon the blood vessels, I have been led to think highly of the remedy. An epidemic fever, many years ago, pervaded the cells of our hospital, which restored the greater part of the maniacs to their reason. These accidental cures struck the late Dr. Bond so lorcibly, that he attempted to excite a fever in several of his patients in manalgia afterwards, by sending them to the swamps of Gloucester county, near to the city, in the state of New Jersey. With what success I have never heard. 3. The cold shower bath. The impulse imparted to the head by the descent of the water upon it adds very much to its efficacy, and gives it great advantages over the plunging bath. 4. The cold shower bath, in succession to the warm bath. While 1 attended the Pennslyvania Hospital, in the summer of 1765,1 often employ- OF THE MIND. 23 ed these two remedies in the manner 1 have men- tioned. 1 kept my torpid patient in the warm bath for an hour or two, and then led him, smoke- ing with vapour to the shower bath, which gave a most powerful shock to his system. It extorted cries and groans from persons that had been dumb for years. In one case it relieved, and in another, it restored reason to my patient; but from his being confined in a damp cell, he died some time after his recovery from his madness, of a pulmo- nary consumption. 5. Exciting an artificial diarrhoea. In the tonic state of madness, purging, I said formerly, acted as a depleting remedy. In manalgia it does good, by exciting a revulsive action or disease, in a less delicate part of the body than the brain. Nature, I said formerly, sometimes cures manalgia in this way. An instance of a cure from this cause oc- curred in our hospital some years ago, in a woman who had been deranged nine years. An acute dysentery cured it in a women in Chester county, after it had continued two years. It may be ex- cited by a laxative diet, or any gently opening medicine. 6. A Caustic applied to the back of the neck, or between the shoulders, and kept open for i224 ON THE DISEASES months or years. This remedy acts by the pre- manent discharge it induces from the neighbour- hood of the brain. Four patients have been cu- red of manalgia h\ our hospital, by abscesses in different parts of the body. One of them had passed a third of his life in the hospital. Dr. Johnson tells us, in his Lives of the Poets, that Dean Swift had a temporary return of his reason during the continuance of an abscess in his eye. 7. A salivation. I know it is difficult to excite this disease in the throat and mouth in ma- nalgia, but the mercury, if given ineffectually for this purpose, will be useful as a general stimulant and tonic. It will moreover serve to remove visceral obstructions, which so generally succeed madness. Where it excites a salivation, it seems to recusitate the mind. I have seen two instan- ces in our hospital, in which a taciturnity of a year's continuance was removed by it. Speech was excited, in one of them, on the very day on which the mercury affected the mouth, and the use of reason followed in a few days afterwards. 8. Exercise. This should consist of swing- ing, seesaw, and an exercise discovered by Dr. Cox, which promises more than either of them, and that is, subjecting the patient to a rotatory mo- OF THE MIND. 22S lion, so as to give a centrifugal direction of the blood towards the brain. He tells us he has cured eight persons of torpid madness by this mode of exercise. I have contrived a machine for this purpose in our hospital, which produces the same effects upon the body which are mentioned by Dr. Cox. These are vertigo and nausea, and a general perspiration. 1 have called it Gyrater. It would be more perfect, did it permit the head to be placed at a greater distance from its ctntre of motion. It produces great changes in the pulse. In one experiment made with it, it increa- sed the pulse from 4 to 88 strokes in one minute, and to 120 in two minutes. It increased its full- ness at the same time. In a second experiment made upon a manalgic patient, it increased the fre- quency of the pulse from 104 in two minutes to 150. In a third experiment it reduced the pulse from 108 in three minutes to 100, and lessened its force. In this patient, the pulse was preternatural- ly active before he entered the gyrater. From the strong impression this mode of ex- ercise makes upon the brain, there is reason to believe it will be a useful remedy in manalgia. A cheap contrivance, to answer all its purposes, might easily be made, by placing a patient upon a board moved at its centre upon a pivot, with his Ff 226 ON THE DISEASES head towards one of its extremities, and then giv- ing it a rotatory motion. The centrifugal fo'ce of the blood would exceed, in this way, that which it receives from the chair employed by Dr. Ccx, or from the gyrater in the Pennsylvania Hospital. In addition to these exercises, pleasant amuse- ments should be contrived for this class of mad people. If they are unhappy, these amusements will suspend their misery. If they are in a tor- pid state, a transient sen-e of pleasure will be ex- cited by them, which may serve to remind them that the chain is still unbroken which united them with their fellow men. 9. Labour has several advantages over exer- cise, in being not only more stimulating, but more durable in its effects, whereby it is more calculated to arrest wrong habits of act on, and to restore such as are regular and natural. It has been remarked, that the maniacs of the male sex in all hospitals, who assist in cutting wood, ma- king fires, and digging in a garden, and the females who are employed in washing, ironing, and scrubbing floors, often recover, while persons, whose rank exempts them from performing such services, languish away their lives within the walls of the hospital. In favour of the benefits of la- bour, in curing this disease, I shall select one lrom OF THE MIND. 227 among many facts that might be mentioned. In the year 1801 I attended an English gentleman, soon after his arrival in America, who was afflicted with this grade of madness. My prescriptions relieved, but did not cure him. He returned to his family in Maryland, where, in the time of hay harvest he was allured into a meadow, and pre- vailed upon to take a rake into his hands, and to assist in making hay. He worked for some time, and brought on thereby a profuse sweat, which soon carried off his disease. This account of his remedy and cure I received from himself, in a very sensible letter written a few weeks after his recovery. I have often wished, and lately ad- vised, that the mad people in our hospital should be provided with the tools of a number of me- chanical arts. Some of them should be labori- ous, and employ the body chiefly; others ingeni- ous, and of a nature to exercise and divert the mind more than the body. None of them should be carried on by instruments, with which it would be easy for the maniacs to hurt themselves or others. For certain exploits of industry or skill, they should receive such rewards in food, or dress, as accord most with their inclinations, for few of them are capable of any higher or other gratifica- tion. The advantages of thus p oducing a cur- rent of new actions, both corporeal and mental. 228 ON THE DISEASES which should continue for weeks and months, and perhaps years, could not fail of being, accompa- nied with great advantages. Some emolument might likewise be derived from their labour to their friends, or to the institution that supported them. What a different view would a number of mad people exhibit, all thus imitating the habits of rational industry, compared with the antic gestures, the rapid or sauntering walks, the list- less attitudes and the vociferous or muttering conversations they hold with themselves, with which they excite pity or horror in all who see them. In both the exercises and labours of mad people, they should be as much separated from each other as possible. We are naturally imitative animals; and our minds are formed in a degree by ambient cir- cumstances; for which reason mad people should associate and work only with persons of sound and healthy minds. 10. Music should not be omitted as a remedy in this state of madness. The tunes employed for this purpose should be of the most invigora- ting nature. OF THE MIND. 229 11. Great pain. Mr. Stewart, the pedestrian traveller, informed me, that he or.ee saw a tran- sient interval of reason induced upon several idiots in Italy, by means of torture, inflicted from pious, but superstitious motives, by some priests. Dr. Cox mentions an instance of chrome madness beini^ cured by trepanning, and of the same good effects being produced by accidental contusions of the head. It is probable that both acted only by inducing pain. The return of reason which I shall say hereafter sometimes takes place in the last hours of life, is probably occasioned, in part, by the bodily pains which attend the passage out of life. Should this remedy be resorted to, it should be induced by means that are not of a de- grading nature, and which are calculated at the same time to excite some violent passion or emo- tion of the mind. 12. Erbhines. These are suggested by the general absence of secretion in the nose in mad people, and by the relief which the discharge of a lew drops of tears affords in tristimania. The insensibility of the nose to the stimulus of com- mon snuff, from its habitual use by that class of patients, forbids us to expect any benefit from it, for which reason the sulphate of mercury, and the L2$0 ON the diseases muriate of ammonia, mixed with a little flour, should be preferred for that purpose. 13. Certain odours. The dyer, formerly mentioned, informed me, that he had often observ- ed the men that were employed in dyeing scarlet to be uncommonly cheerful, and sometimes to sing from morning till night, The odour which produces this effect is derived from a mixture of cochineal with a solution of tin in the nitric acid. The exhilaration produced by the fragrance of a flower garden in the spring of the year, and of the Spice Islands in the Indian Ocean, favours the idea still more, of exciting the brain by means of plea- sant odours applied to the organ of smelling. 14. What would be the effect of loud and un- common sounds, acting through the ears, upon the brain and mind in this disease ? Menalgic pa. tients, it has been observed, are much excited by the military music that sometimes passes by the Pennsylvania Hospital. It is still more in fa- vour of loud sounds, or noises, in manalgia, that in the lowest stage of typhus fever, they have re- called departing life; and in asphixia, restored it from its apparent extinction in death. OF THE MIND. 231 15. Exciting certain stimulating passions and emotions, also the domestic affections. I mentioned several instances of the good effects of terror, in tristimania, and in tonic madness in its declining state. To be useful in manal- gia, it should be often repeated. Of the good benefits of anger, I shall mention a striking instance. Mr. Derborow, whose name was men- tioned formerly, during his long confinement in our hospital, in a state of manalgia, became silent for several months. Many attempts were made to compel him to speak, but to no purpose. The late Dr. Thomas Bond at length contrived to force him to break his long and obstinate silence. It was the practice of Mr. Derborow to amuse him- self occasionally during this time in drawing. One day the doctor looked over his shoulder, and saw the picture of a flower under his pencil. 'A very prettv cabbage," said the Doctor. "You are a fool and a liar," said Mr. Derborow, " it is a flower." From that time he continued to speak as usual. Reading aloud and incorrectly to pa- tients in this situation has sometimes induced a transient feeling of uneasiness or irritation, which has unsealed their lips, and revived their former habits of conversation. 232 ON THE DISEASES The advantages to be expected from exciting the domestic affections will appear from die fol- lowing fact. A woman in our hospital was de- livered, many years ago, of a fine child during her derangement, which was of a chronic and tor- pid nature. The affection which was suddenly awakened for this child, removed her disease for several days. The child was taken from her breast, lest it should contract the seeds of madness from her milk. Her disease immediately returned, and she is now, and probably always will be, an incu- rable tenant of our hospital. There are several medicines which have been given in this disease, upon which 1 shall make a few remarks. These are, 16. Opium, iron, the datura stammonium, strong infusions of green tea and green coffee, garlic, va- lerian, the nitrous oxyd, and electricity. "I have administered all these medicines in this disease in the Pennsylvania Hospital, and some of them for sever/tl months, but never in a single instance with success, when given alone. Garlic now and then produced a temporary frequency and fulness in the pulse, and elt ctricity nas pro- duced a transient excitement in the temper, but OF the mind. 233 neither of them made a permanent impression upon the disease. Where a recovery has suc- ceeded the use of any of those medicines, I have supposed the disease was cured by time, instances of which will be mentioned hereafter. In thus stating the inefficacy of the above medicines in manalgia, I would by no means rej -ct them alto- gether. They may be given as auxiliaries to those more powerful and rational remedies which agitate .the whole body and mind. In the use of all our remedies for manalgia, an advantage will arise from prescribing them in suc- cession and rotation, and in choosing certain sea- sons of the year, according to the habits of the pa- tient, for their exhibition. To encourage us to persevere for years in the use of remedies for this disease, or to wait for a cure from the hand of time, founded upon those spontaneous changes that are always going forward in the human body, I shall select two cases of re- coveries from among many others, the one from the former, the other from the latter cause. 1. In the year 1795 a young man of *the name of Donaldson, from York county, in Pennsylva- nia, was admitted into our hospital, in the lowest g c 234 ON THE DISEASES state of manalgia. He had been in that situation between four and five years. He appeared to have no mind, and scarcely any locomotive powers. When placed at the head of a pair of stairs, he rolled to the bottom of it. By means of most of the remedies I have recommended, he was nearly cured. He acquired the use of his speech, knew his attendants, and called me by my name when I visited him. Unhappily, in his progress to a per- fect cure he was attacked with a malignant fever, and died in the hospital on the fifth day of his disease. 2. The following account of a spontaneous re- covery was communicated to me, many years ago, by Dr. A. Hunter, with his History of the lunatic Asylum in York, in Great Britain. "On the twenty-fifth of October, 1778, a sea- faring person, about forty years of age, was re- commended to the Lunatic Asylum for cure. About two years before that time he hue sustained a considerable loss by sea, which operated so vio- lently upon his mind, as to deprive him almost instantly, of all his reasoning faculties. In that state of insensibility he was received into the Asy- lum. During his abode there, he was never ob- served to express any desire for nourishment; and OF THE MIND. 235 so great was his inattention to this particular, that for the first six weeks it was necessary to feed him in the manner of an infant. Food and medicines were equally indifferent to him. A servant un- dressed him at night, and dressed him in the morning ; after which he was conducted to his seat in the common parlour, where he remained all day with his body bent, and his eyes fixed upon the ground. From all the circumstances of his behaviour, he did not appear to be capable of re- flection. Every thing was indifferent to him ; and from the fairest judgment that could be formed, he was considered by all about him as an animal converted nearly into a vegetable. In this state of insensibility he remained till the morning of Tues- day the fourteenth of May, 1783, when, upon en- tering the parlour, he saluted the recovering pa- tients with a " Good morrow to you all." He then thanked the servants of the house, in the most affectionate manner, for their tenderness to him ; of which, he said, he began to be sensible some weeks before, but had not till then the resolution to express his gratitude. A few days after this unexpected return to reason, he was permitted to write a letter to his wife, in which he expressed himself with decency and propriety. At this time he seemed to have a peculiar pleasure in the enjoy- ment of the open air, and in his walks conversed 236 ON THE DISEASES with freedom and serenity. Talking with him on what he felt during the suspension of reason, he said that his mind was totally lost; but that about two months before his return to himself, he began to have thoughts and sensations; these, however, only served to convey to him fears and apprehen- sions, especially in the night time. With regard to his medical treatment, I shall only observe, that the medicines usually prescribed for melancholic persons were, in his case, studiously avoided, and instead of evacuants, c ordials and a generous diet were constantly recommended. Had the natural powers been weakened, I am satisfied that the mind never would have regained her empire. During the remainder of his stay in the Asylum, he con- tinued to- behave himself with steadiness and pro- priety. He ate and drank moderately, and upon all occasions shewed a gentle and benevolent dis- position. Finding his mind sufficiently strong, he returned to his family on the 28th of May, 1783. Soon after this he was appointed to the command of a ship employed in the Baltic Trade, in which service he is at this time engaged." I shall dismiss the history of all the different forms of madness, and of their respective remedies, by remarking that they do not always occur in the order in which they have been described. OF THE MIND. 237 Partial and general madness sometimes precede and sometimes succeed each other. Manicula sometimes exists without mania, and both, with- out being succeeded by manalgia. There are in- stances in which manalgia has preceded mania, and manicula; and lastly, we now and then see thtm all combine, and alternate with each other. From this view of the successive and alternate changes of the different forms of madness into each other, we derive fresh proofs of the unity of its cause, and the necessity of renouncing all prescrip- tions for its names, and of constantly and close- ly watching the disease, in order to vary our re- medies with its varying forms. I shall now make a few remarks, which are alike applicable to all the forms of general madness-. 1. Great regard should be had to cleanliness in the persons and apartments of mad people. This i indispensably necessary, not only for their com- fort, but their cure. A deranged man, with a ragged dress, a dirty skin, long nails and beard, and uncombed hair, or with his dress and person in neat order, in a filthy room, loses his consci- ousness of his personal identity ; and until this be restored, it is in vain to expect a return of the na- tural habits of his mind. A close stool, with a s 238 ON THE DISEASES pan half filled with water, in order to suffocate the fcetor of his evacuations, should be fixed in his room, with a cover, which should fall down of it- self upon the stool after it is used. 2. Mad people should never be visited, nor even seen by their friends, and much less by stran- gers, without being accompanied by their physcian, or by a person t© whom he shall depute his power over them. The dread of being exposed, and gazed at in the cell of a hospital by an unthinking visitor, or an unfeeling mob, is one of the great> est calamities a man can anticipate in his tendency to madness. The apprehension of it was so dis- tressing to a young gentleman in this city in a fit of low spirits, that he prevented it, by discharg- ing the contents of a loaded musket through his brain. But there is another ad vantage from con- cealing the persons of mad people from the eyes of visitors and the public. The di rase is supposed to fix something of a repelling nature upon per- sons and families, and hence it i; often concealed or denied. Now, by rendering the place in which mad people are confined, private—I had almost said sacred—-members of families may be sent there without its being known. Nay, they will be sent there upon the first appearance of the disease, *n order to prevent its being known, and the dis- OF THE MIND. 239 ease thereby be more frequently cured. This pri- vacy would act with peculiar force upon the fe- male sex. The obliquity and convulsions of the moral faculties, which sometimes take place in madness, would in this way never be known, or if known, would be forgotten, or never divulged. To render a hospital still more agreeable, or less the object of aversion by the female sex, they should be carefully separated from the men, and they should be nursed only by women. 3. In the history of all the forms of general madness, it was remarked that they were all attend- ed, now and then, with the cheerfulness of ameno- mania, but oftener with the distress of hypochon- driasm. In the latter case, it will be necessary to use all the precautions to prevent suicide, that were recommended in treating upon that disease. 4. We should be careful to distinguish between a return of reason and a certain cunning, which enables mad people to talk and behave correctly for a short time, and thereby to deceive their at- tendants, so as to obtain a premature discharge from their place of confinement. To prevent the evils that might arise from a mistake of this kind, they should be narrowly watched during then convalescence," nor should they be discharged, un 240 ON THE DISEASES til their recovery had been confirmed by weeks of correct conversation and conduct. Three in- stances of suicide have occurred in patients soon after they left the Pennsylvania Hospital, and while they were receiving the congratulations of their friends upon their recovery. The disease, in these cases, was probably revived by two causes, 1. By means of association, from the sight of persons or objects that first excited it, or that were first connected with it; and, 2. By exchanging the large and noisy society of the hospital, for the comparative soilitude and silence of a private family. The madness of Dr. Zimmerman, which had been suspended for three months by travelling, returned on the day he entered his own house. To prevent this fatal or distressing recurrence of madness, it would be a good practice to send pa- tients abroad, or to reside for some time among strangers, before they returned to their families. All the means of destroying themselves should, at the same time, be kept out of their way. OF THE MIND. 241 The recurrence of madness, after it has been cured, is no objection to the power of medicine over it. There are frequent returns of catarrh, pleurisy, and intermitting fever, after they have been cured, and yet we do not ascribe them to the uncertainty or imperfection of our science. Of twenty-five persons that were cured of madness, by Mr. Pinel, but two relapsed in the course of five years, which is probably much less than the relapses which occur from the other diseases that were mentioned. I cannot conclude this part of the subject of these Inquiries, without lamenting the want of some person of prudence and intelligence in all public receptacles of mad people, who should live constandy with them, and have the exclusive di- rection of their minds. His business should be to divert them from conversing upon all the sub- jects upon which they had been deranged, to tell them pleasant stories to read to them select pas- sages from entertaining books, and to oblige them to read t • him ; to superintend their labours of body and mind ; to preside at the table at which they take their meals, to protect them from rude- ness and insults from their keepers, to walk and ride with them, to partake with them in their amuse- ments, and to regulate the nature and measure of 242 ON THE DISEASES their punishments. Such a person would do more good to mad people in one month, than the visits, or the accidental company, of the patient's friends would do in a year. But further. We naturally imitate the manners, and gradually acquire the temper of persons with whom we live, provided they are objects of our respect and affection. This has been observed in husbands and wives, who have lived long and happily together, and even in servants, who are strongly attached to their masters and mistresses. Similar effects might be expect- ed from the constant presence of a person, such as has been described, with mad people, indepen- dently of his performing for them any of the ser- vices that have been mentioned. We render a limb that has been broken, and bent, straight, only by keeping it in one place by the pressure of splints and bandages. In like manner, by keep. ing the eyes and ears of mad people under the constant impressions of the countenance, gestures, and conversation of a man of a sound understand- ing, and correct conduct, we should create a pres- sure nearly as mechanical upon their minds, that could not fail of having a powerful influence, in conjunction with other remedies, in bringing their shattered and crooked thoughts into their original and natural order. OF THE MIND. 243 In reviewing the slender and inadequate means that have been employed for ameliorating the con- dition of mad people, we are led further to la- ment the slower progress of humanity in its efforts to relieve them, than any other class of the afflict- ed children of men. For many centuries they have been treated like criminals, or shunned like beasts of prey; or, if visited, it has been only for the purposes of inhuman curiosity and amusement. Even the ties of consanguinity have been dissolv- ed by the walls of a mad house, and sons and brothers have sometimes languished or sauntered away their lives within them, without once hear- ing the accents of a kindred voice. Happily these times of cruelty to this class of our fellow- creatures, and insensibility to their sufferings, are now passing away. In Great Britain, a humane revolution dictated by modern improvements in the science of the mind, as well as of medicine, has taken place in the receptacles of mad people, more especially in those that are of a private nature. A similar change has taken place in the Pennsyl- vania Hospital, under the direction of its present managers, in the condition of the deranged sub- jects of their care. The clanking of chains, and the noise of the whip, are no longer heard m their cells. They now taste of the blessings of air, and light and motion, in pleasant and shaded walks 244 ON THE DISEASES in summer, and in spacious entries, warmed by stoves in winter, in both of which the sexes are separated, a id alike protected from the eye of the visitors of the hospital. In consequence of these advantages they have recovered the human figure, and, with it, their long forgotten relationship to their friends and the public. Much, however, remains yet to be done for their comfort and relief. To animate us in filling up the measure of kind- ness which has been solicited for them, let us re- collect the greatness of its object. It is not to feed nor clothe the body, nor yet to cure one of its common diseases, it is to restore the disjoint- ed or debilitated faculties of the mind of a fellow- creature* to their natural order and offices, and * The following short extract, taken down by Mr. Coats, from the constant conversation of a young man of a good ed ucation, and respectable connexions, now deranged in the Pennsylvania Hospital, will exhibit an affecting specimen of this disjointed state of the mind, and of the incoherence of its operations. " No man can serve two masters. I am king Philip of Macedonia, lawful son of Mary queen of Scuis, born in Philadelphia. I have been happy enough ever since I have seen general Washing- ton with a silk handkerchief in High-street. Money com- mands sublunary things, and makes the mare go; it will buy salt mackerel, made of ten-penny nails. Enjoyment is the happiness of virtue. Yesterday cannot be recalled. 1 can only walk in the night-time when I can eat pud- OF THE MIND. 245 to revive in him the knowledge of himself, his family, and his God. But in performing this achievement of skill and humanity, we not only confer a positive good, but we remove a positive evil, which has no par- rallel in the list of human sufferings. If there were no other reason to believe this was the case, than the distress which takes place from a slight irregu- larity in the circulation of the blood in the brain ding enough. I shall be eight years old to-morrow. They say R. W is in partnership with J. W. I believe they are about as good as people in common—not better, only on certain occasions, when, for instance, a man wants to buy chincopins, and to import salt to feed pigs. Tanned leather was imported first by lawyers. Morality with vir- tue is like vice not corrected. L. B. came into your house and stole a coffee-pot in the twenty-fourth year of his ma- jesty's reign. Plum-pudding and Irish potatoes make a very good dinner. Nothing in man is comprehensible to it. Born in Philadelphia. Our forefathers were better to us than our children, because they were chosen for their honesty, truth, virtue and innocence. The Queen's broad R originated from a British forty-two pounder, which makes two large a report for me. I have no more to say. I am thankful I am no worse this season, and that I am sound in mind and memory, and could steer a ship to sea, but am afraid of the thiller. ****** ****** son 0f jyrarv queen of Scots. Born in Philadelphia. Born in Philadel- phia. King of Macedonia. 246 ON THE DISEASES in a great majority of our dreams, it would be sufficient to render their assertion probable ; but we have many proofs of its being strictly true. The tearing of clothes, so common in this disease, was one of the instituted signs of deep distress among the Jews, and it was so probably, from its being one of its natural signs among the nations of the East. The hallooing, stamping with the feet, and the rattling of chains, so generally practi- sed by mad people, are all resorted to, in order to excite such counter-impressions upon their ears, as shall suspend or overcome, by their force, the anguish of their minds. They wound and man- gle their bodies for the same purpose. Even in those solitary cases of general madness, which are accompanied with singing and laughter, there is good reason to believe the heart is depressed with sadness. Nor are the silence, and seeming apa- thy of manalgia, always signs of the absence of misery. The " willow weeps," says the poet, w but cannot feel; the torpid maniac feels, but cannot weep." In maintaining the general exist- ence of misery in all the forms of derangement, I am supported, not only by the acts that have been mentioned, but by the authority of Shakspeare, in the following view of the images and feelings that usually harrow up the imaginations of mad peo- ple. OF THE MIND. 247 « Who gives any thing (says Edgar) to poor Tom, Whom the foul fiend has led through fire, And through flame, through ford, and whirlpool, Ovf r bog and quagmire, that hath laid Knives under his pillow, and halters in his pew, Set r*t's-bane by his porridge, made him to Ride upon a bay trotting horse, over four-inch Bridges, and to course his own shadow for a traitor." And again, Lear, in a language still more ex- pressive of suffering, complains, -« I am bound Upon a wheel of fire, that mine own tears Do scald like molten lead." It is no objection to the correctness of this de- cription of the distress and horror which distracts the minds of mad people, that they often have no recollection of them after their recovery. Happily for them! this is prevented, by derangement af- fecting the memory as well as the understanding. Even in those cases of manalgia in which the mind loses its sensibility to misery, and the sub- jects of it cease to be objects of our sympathy, they do not forfeit their claims to our good offices. Though insensible of mental pain, they are still sensible of kindness, and of corporeal pleasure. A pleasant look, a kind word, an orange, an apple, or even a flower, presented to them in an affection- 248 ON THE DISEASES ate manner, are cordials and donations of inestima- ble value. With these transient and casual favours should be united savoury food. This is the more necessary to them, as their senses of smell and touch, and often of hearing, are so much im- paired as to cease to afford them any pleasure. Perhaps their food is more enjoyed by them upon that account. I shall now mention the signs of a favourable and unfavourable issue of madness, in all the forms of it which have been described. The longer its remote and predisposing causes have acted upon the brain, and mind, the more dangerous the disease, and vice versa. General madness which succeeds tristimania, or that comes on gradually, is more difficult to cure, than that which comes on suddenly. Here we see its affinity to fever. Madness, which arises from a hereditary pre- disposition, is said to be more difficult to cure, than that which follows a predisposition to it that has been acquired. It is certainly excited more easily, and is more apt to recur when cured, but OF THE MIND. 249 in general, its paroxysms yield to medicine as readi- ly as madness from an acquired predisposition. Madness from corporeal causes is more easily cured than from such as are mental. The younger the subject, the more easy the cure. Of 467 persons cured in Bethlehem Hos- pital, between the years 1784 and 1794, who were between 20 and 50 years of age, 200 of them were between 20 and 30. It is rarely cured in old people. Mr. Halsam says, of 31 persons in advanced life, who were ad- mitted into Bethlehem Hospital, but four were cu- red in the course of ten years. Persons who have children are more difficult to cure than those who are childless. It is more easily cured in women than in men. Mania yields more readily to medicine than ma- nicula, or manalgia. An 100 patients in mania in its furious state, and the same number in its chronic state, were selected in the Bethlehem Hos- pit-'.l, in order to determine their relative danger and obstinacy. Of the former 62 were cured, and of the latter but twenty-seven, i i 250 ON THE DISEASES A paroxysm of mania succeeding manicula, or manalgia, is favourable. A fever succeeding bleeding is favouable. It shows a suffocated disease to be changed into a diffused one. A malignant fever, I remarked for- merly once cured a number of maniacs in our hospital. Remissions andi ntermissions of violent mental excitement, are always favourable. Lucid intervals in manicula and manalgia are likewise favourable. They show that torpor has not completely taken possession of the brain. Abscesses in any part of the body are favoura- ble. I formerly mentioned instances of recove- ries which succeeded them. A running from, or moisture in thenose, after it has been long dry, is favourable. Warm and moist hands, after they have been long cold and dry, are favourable. A cessation of burning in the feet is favourable. OF THE MIND. 251 General anasarca is favourable, provided it has been preceded by bleeding. It was followed by a recovery in two cases in the Pennsylvania Hospi- tal in the year 1811. The continuance of hysterical symptoms, or their revival, after being long absent, is always fa- vourable. The latter shows the diseases to be passing from its seat in the blood-vessels to the nerves. A moderate degree of obesity occuring dur- ing a remission of the disease is favourable. A greater degree of it is unfavourable. A return of one regular stool daily, and at an habitual hour, is favourable. A diarrhoea, when moderate, is favourable. Madness, from the common causes of fever, from parturition, and from strong drink, generally yield to the power of medicine. Madness from laesions of the brain is seldom cured, 252 ON THE DISEASED Madness which succeeds epilepsy, or that is alternated with it, is, I believe, always incurable. Madness which succeeds head-ache, palsy, and fatuity, is generally incurable. Madness from emotions of the mind, such as an- ger, joy and terror, is more easily cured than when it arises from the passions. From the former causes it comes on suddenly, from the latter gra- dually. Madness is difficult to cure, when it arises from the revival of an old and dormant passion, excited by association, especially when that passion is love or grief. It is remarkable, that the love which causes madness does not revive with its cure. Gaiety, timidity, and good humour, are favour- able. Ill-temper is favourable. Weeping is favourable, when the disease has been preceded by hypocondriasm. It shows it to be" changing into the less dangerous and dis- tressing disease of hysteria. Pensiveness and taciturnity often accompany and succeed a recovery from this disease. This OF THE MIND. 253 is elegantly described in Orlando Furioso, after his recovery from madness induced by the unfaithful- ness of his beloved Angelica. Slow recoveries are most favourable. A discharge of blood from the hsemorrhoidal vessels, and the return of the menses, where they have been obstructed, are aways favourable. In three cases of madness that have occurred du- ring pregnancy, within my knowledge, parturition did not cure nor even mitigate them. A return of spelling correctly, after it had been suspended, is favourable ; so is a return of delica- cy, more especially in the famale sex. The return of an habitual disease or appetite, shows an abatement of the violence of madness and is always favourable. The return of an habitual employment or of any of the habits of the under- standing or the affections, that had been suspend- ed, is still more favourable. I shall mention in- stances of each of them. Sir George Baker declared the king of Great- Britain to be convalescent from his first attack 254 ON THE DISEASES of madness, as soon as he heard him speak with a rapidity that had always been natural to him, and which he had lost during his insanity, I attended a young man of the name of Wilki- son, in the Pennsylvania Hospital, in whom a ha- bit of stammering was suspended during his de- rangement, but which returned as soon as he be- gan to mend. The return of diseases that are painful, such head-ach, the rheumatism, the piles, or cough, also of tremors, and cutaneous eruptions, is still more favourable than the two cases of disease that have been mentioned. A revival of an appetite for gingerbread, in a young man in our hospital, who had been fond of it when in health, was soon afterwards followed by his complete recovery. A young lady in the neighbourhood of Phila- delphia, who had been my patient for several weeks in an attack of madness from a fever, was observ- ed by her family to call for her pen, ink, and common-place book, upon a Sunday. She had been in the practice of copying select pieces of poetry into it, for^many years, upon that day of the OF THE MIND. 255 weelc. At this time she discovered none of the common signs of the return of reason by her con- duct or conversation. Trifling as this incident appeared, I encouraged her parents to expect from it a favourable change in her disease. It took place as I expected, and she recovered perfectly in the course of a few weeks. A female patient of mine, who had acquired pious habits when a child, practised them with great regularity during her derangement. Her recovery was marked by the gradual neglect of her devotion, and by a return of the gay and dissi- pated practices of her middle life. A Mrs. D----, whom I supposed, for several months, had recoverd from madness, under my care, said to me one day, in passing by her in our hospital, upon my asking her how she was, " that she was perfectly well, and that she was sure this was the case, for that she had at last ceased to hate me," A similar instance of a perfect recovery suc- ceeding the revival of domestic respect and affec- tion occurred in a Miss H, L, who was confined in our hospital in the year 1800. For several weeks she discovered every mark of a sound mind 256 ON THE DISEASES except one. She hated her father. On a certain day she acknowledged, with pleasure, a return of her filial attachment and affection for him ; soon after she was discharged cured. Spontaneous recoveries now and then occur, af- ter the disease has continued 18 and zO years. A recovery after the former period has lately taken place in a German farmer, in the county of Mont- gomery, in this state. Maniacal patients sometimes die of its tonic or acute state, but in its chronic forms they more commonly die of some one of the following dis- eases. 1. Atrophy. Dr. Greding says 68 out of 100 patients die of this wasting disease. 2, Pulmonary consumption. It is remarkable that this disease does not so often suspend mad- ness, as madness does pulmonary consumption. 3. Dropsy, particularly hydrothorax and ana- sarca, where they have not been preceded by bleed- ing-. The latter disease aided madness in put- ting an end to the miserable life of Mr. Cowper, OF THE MIND. 257 4. A single convulsive fit, epilepsy, palsy, and apoplexy. 5. Fevers. 6. The disease induced by fasting. It has been remarked, that patients who have long been confined in mad houses sometimes lose their hearing, but seldom their sight. I remarked formerly, that the ears are oftener affected with false perceptions than the eyes, in mad people ; and from the nature of the disease which produces those false perceptions, it is easy to conceive that the sense of hearing must sooner perish than the sense of sight. Most of mad people discover a greater or less degree of reason in the last days or hours of their lives. Cervantes therefore discovers both obser- vation and judgment, in bringing Don Quixote to his senses just before he dies. Thus the sun, after a cloudy day, sometimes darts a few splendid rays across the earth just before he descends be- low the horison. I have ascribed this resuscita- tion of reason in the paroxysm of death to the k k 258 ON THE DISEASES diseased blood-vessels relieving themselves by an effusion of water in the ventricles of the brain, or to the remains of the excitement of the system, awakened by fever, or pain, taking refuge in the mind. OF THE MIND. 259 CHAPTER IX. Of Demence, or Dissociation. RELATED to intellectual madness is that dis- ease of the mind, which has received from Mr. Pinel the name of demence. The subjects of it in Scotland are said to " have a bee in their bonnets." In the United States, we say thev are "flighty," or hair-brained," and, sometimes, a " little cracked. I have preferred naming it, from its principal symptom, dissociation, It consists not in false perception, like the worst grade of madness, but of an association of unre- lated perceptions, or ideas, from the inhability of the mind to perform the operations of judgment and reason. The perceptions are generally exci- ted by sensible objects; but ideas, collected toge- ther without order, frequently constitute a parox- ysm of the disease. It is always accompanied with great volubility of speech, or with bodily gestures, performed with a kind of convulsive ra^ 260 ON THE DISEASES pidity. We rarely meet with this disease in hos- pitals; but there is scarely a city, a village, or a country place, that does not furnish one or more instances of it. Persons who are afflicted with it are good tempered and quarrelsome, ma- licious and kind, generous and miserly, all in the course of the same day. In a word, the mind in this disease may be considered as floating in a balloon, and at the mercy of every object and thought that acts upon it. It is constant in some people, put it occurs more frequently in parox- ysms, and is sometimes succeeded by low spirits. The celebrated Lavater was afflicted with it; and although he wrote with order, yet his conversa- tion was a mass of unconnected ideas, accompa- nied with bodily gestures, which indicated a de- gree of madness. I shall insert an account of a visit paid to him at Zurich by the Rev. Dr. Hun- ter, an English clergyman, in which he exempli- fied the state of mind I wish to describe. " I was detained," says he, the whole morn- ing by the strange, wild, excentric Lavater, in various conversations. When once he is seta going, there is no such thing as stopping him till he runs himseli out of breath. He starts from subject to subject, flies from book to book, from OF THE MIND. 261 pictuie to picture; measures your nose, your eye, your mouth, with a pair of compasses; pours forth a torrent of physiognomy upon you ; drags you, for a proof of his dogma, to a dozen of clo- sets, and unfolds ten thousand drawings; but will not let you open your lips to propose a difficulty ; crams a solution down your throat, before you have uttered half a syllable of your objection. He is as meagre as the picture of famine; his nose and chin almost meet. I read him in my turn, and found little difficulty in discovering, amidst great genius, unaffected piety, unbounded benevolence and moderate learning, much ca- price and unsteadiness ; a mind at once aspiring by nature, and grovelling through necessity; an endless turn to speculation and project; in a word, a clever, flighty, good natured, necessitous man." I said formerly, that hysteria consisted in mo- bility of the nervous and muscular system. Dis- sociation seems to be occasioned by a similar mobility of that part of the brain which is the seat of the mind. The remedies for it, when it is attended with great excitement, as it generally is, should be, \ 262 ON THE DISEASES bleeding, low diet, purges, and all the other reme- dies for reducing morbid excitement in the brain, recommended formerly for the cure of intellectual madness. When the disease is periodical, bark, and other tonics, should be given in its intervals. OF THE MIND. 263 CHAPTER X. On Derangement in the Will. TWO opinions have divided philosophers and divines upon the subject of the operations of the will. It has been supposed by one sect of each of them to act freely ; and by the others to act from necessity and only in consequence of the stimulus of motives upon it. Both these opini- ons are supported by an equal weight of argu- ments ; and however incomprehensible the union of two such opposite qualities may appear in the same function, both opinions appear to be alike true. The will is affected by disease in two ways. I. When it acts without a motive, by a kind of involuntary power. Exactly the same thing takes place in this disease of the will, that occurs when the arm or foot is moved convulsively without 264 ON THE DISEASES an act of the will, and even in spite of it. The undersanding, in this convulsed state of the will, is in a sound state, and all its operations are per- formed in a regular manner. When the will be- comes the involuntary vehicle of vicious actions, through the instrumentality of the passions, I have called it moral derangement. For a more particular account of this moral disease in the will, the reader is again referred to a printed lecture de- livered by the author, in the university of Penn- sylvania., in November 1810, upon the study of Medical Jurisprudence, in which the morbid ope- rations of the will are confined to two acts. viz. murder and theft. I have selected those two symptoms of this disease (for they are not vices) from its other morbid effects, in order to rescue persons affected with them from the arm of the law, and to render them the subjects of the kind and lenient hand of medicine. But there are several other ways, in which this disease in the will dis- covers itself, that are not cognizable by law. I shall describe but two of them. These are, lying and drinking. 1. There are many instances of persons of sound understandings, and some of uncommon talents, who are affected with this lying disease in the will. It differs from exculpative, fraudulent and OF THE MIND. 265 malicious lying, in being influenced by none of the motives of any of them. Persons thus diseased cannot speak the truth upon any subject nor tell the same story twice in the same way, nor de- scribe any thing as it has appeared to other people. Their falsehoods are seldom calculated to injure any body but themselves, being for the most part of a hyberbolical of boasting nature, but now and then they are of a mischievous nature, and injuri- ous to the characters and property of others. That it is a corporeal disease, I infer from its some- times appearing in mad people, who are remarka- ble for veracity in the healthy states of their minds, several instances of which I have known in the Pennsylvania Hospital. Persons affected with this disease are often amiable in their tempers and manners, and sometimes benevolent and cha- ritable in their dispositions. Lying, as a vice, is said to be incurable. 1 in same thing may be said of it as a disease, when it appears in adult life. It is generally the result of a defective education. It is voluntary in child- hood, and becomes involuntary, like certain mus- cular actions, from habit. Its only remedy is, bodily pain, inflicted by the rod, or confinement. L L 266 ON THE DISEASES or abstinence from food ; for children are incapable of being permanently influenced by appeals to rea- son, natural affection, gratitude, or evena sense of shame. 2. The use of strong drink is at first the effect of free agency. From habit it takes place from necessity. That this is the case, 1 infer from per- sons who are inordinately devoted to the use of ardent spirits being irreclaimable, by all the con- siderations which domestic obligations, friendship, reputation, property, and sometimes even by those which religion and the love of life, can sug- gest to them. An instance of insensibility to the last, in a habitual drunkard, occured some years ago in Philadelphia. When strongly urged, by one of his friends, to leave off drinking, he said, " Were a keg of rum in one corner of, a room and were a cannon constantly discharging balls between me and it I could not refrain from pass- ing before that cannon, in order to get at the rum." The remedies for this disease have hitherto been religious and moral, and they have some- times cured it. They would probably have been more successful, had they been combined with OF THE MIND. 267 such as are of a physical nature. For an account of several of them, the reader is referred to the first volume of the author's Medical Inquiries and Observations. To thataccount of physical reme- dies I shall add one more, and that is, the esta- blishment of a hospital in every city and town in the United States, for the exclusive reception of hard drinkers. They are as much objects of public humanity and charity, as mad people. They are indeed more hurtful to society, than most of the deranged patients of a common hos- pital would be, if they were set at liberty. Who can calculate the extensive influence of a drunken husband or wife upon the property and morals of their families, and of the waste of the former, and corruption of the latter, upon the order and hap- piness of society ? Let it not be said, that confin- ing such persons in a hospital would be an in- fringement upon personal liberty, incompatible with the freedom of our governments. We do not use this argument when we confine a thief in a jail, and yet, taking the aggregate evil of the greater number of drunkands than thieves into consideration, and the greater evils which the in- fluence of their immoral example and conduct introduce into society than stealing, it must be obvious, that the safety and prosperity of a com- » 268 ON THE DISEASES munity will be more promoted by confining them, than a common thief. To prevent injustice or oppression, no person should be sent to the con- templated hospital, or sober house, without be- ing examined and committed by a court, consist- ing of a physician, and two or three magistrates, or commissioners appointed for that purpose. If the patient possess property, it should be put into the hands of trustees, to take care of it. With- in this house the patient should be debarred the use of ardent spirits, and drink only, for a while, such substitutes for them, as a physician should direct. Tobacco, one of the provocatives of in- temperance in drinking, should likewise be gradu- ally abstracted from them, Their food should be simple, but for a while moderately cordial. They should be employed in their former re- spective occupations, for their own, or for the pub- lic benefit, and all the religious, moral, and physi- cal remedies, to which 1 have referred, should be employed at the same time, for the complete and radical cure of their disease. 2. Besides the disease in the will, which has been described, it is subject to such a degree of debility and torpor, as to lose all sensibility to the stimulus of motives, and to become incapable of OF THE MIND. 269 acting either freely, or from necessity. In this respect it resembles a paralytic limb. We some- times say of persons who are governed by their friends, or a favourite, that " they have no will of their own." This is strictly true. If left to themselves, they would neither buy nor sell, nor transact any kind of business. They xoill and prefer nothing, and they do nothing, but what is closely connected with their animal existence. It is from the habitual want of exercise in the will in slaves, that it is so apt to acquire this paralytic state; and it is because we are deprived of its co-operation with our medicines in a desire of life, that we are less successful in curing their diseases tinder equal circumstances, than the dis- eases of freemen. Animal magnetism, Mr. Bris- set informed me, performed many cures of light diseases upon the white people in the West In- dies, but not a single slave was benefited by it, and probably from the cause that has been men- tioned. I have never been consulted in this disease of the will, but I have no doubt stimulating and tonic remedies, preceded by depletion, would be useful in it. Persons afflicted with this disorder of the mind should be placed in situations, \v 270 ON THE DISEASES which they will be compelled to use their wills, in order to escape some great and pressing evil. A palsy of the limbs has been cured by the cry of fire, and a dread of being burned. Why should not a palsy of the will be cured in a similar way9 OF THE MIND. 271 CHAPTER XI. Of Derangement in the Principle of Faith, or the Believing Faculty. AS this faculty has not yet found its way into our systems of physiology, I shall briefly remark, that 1 mean by it that principle in the mind, by which we believe in the evidence of the senses, of reason, and human testimony. It is as much a native faculty as memory or imagination. The objects of human testimony are extensive and important. St. Paul alludes to them in the fol- lowing passage of the eleventh chapter of his Epistle to the Hebrews. " Through faith we un- derstand that the worlds were framed by the word of God, so that things which are seen were not made of things which do appear." The greatest part of all we believe of history, geography, and public events, and all that we believe of our rela- tion to our parents, brothers and sisters, by the ties of consanguinity, are derived from it. Hap- pily for us! its operations are involuntary in it? 272 ON THE DISEASES sound state. Happily for us, likewise ! a source of knowledge, so necessary to individual comfort and social existence, has not been made depen- dant upon our senses, nor left to the slow induc- tions of reason. The world could not exist in its present circumstances without it. It is no objection to its necessity and usefulness, that we are sometimes deceived by it. The same objec- tions applies with equal force to our senses and reason, as sources of knowledge. Persons affected with this disease in the principle of faith, as far as relates to human testimony, believe and report every thing they hear. They are inca- pable of comparing dates and circumstances, and tell stories of the most improbable and incongru- ous nature. Sometimes they propagate stpries that are probable, but false; and thus deceive their friends and the public. There is scarcely a village or city, that does not contain one or more persons affected with this disease. Horace de- scribes a man of that character in Rome, of the name of^pella. The predisposition of such persons to believe what is neither true, nor proba- ble, is often sported with by their acquaintances, by which means their stories often gain a currency through whole communities. OF THE MIND. 273 It is probable the confinement of persons afflict- ed with this malady, immediately after they hear any thing new, might cure them. Perhaps ridi- cule might assist this remedy. 1 think I once saw it effectual in an old quidnunc during the revo- lutionary war. This faculty of the mind is subject to disorder as well as to disease ; that is, to an inability to be- lieve things that are supported by all the evidence that usually enforces belief. Mr. Burke has de- scribed the conduct of persons affected with the disorder in the following words : " They be- lieve nothing that they do not see, or hear, or mea- sure by a twelve inch rule." An Indian once ex- pressed the state of mind in which this torpor in the principle of faith takes place, by saying, when a truth was proposed to his belief, " that it would not believe for him." This incredulity is not confined to human testimony. It extends to the evidence of reason, and (it has been said) of the senses. The followers of Dr. Berkley either felt, or affected, the last grade of this disorder in the principle of faith. That it is often affected, I infer from persons who deny their belief in the utility of medicine, as practised by regular bred m m 274 ON THE DISEASES physicians, believing implicitly in quacks ; also from persons who refuse to admit human testimo- ny in favour of the truths of the christian religion, believing in all the events of profane history; and, lastly, from persons who contradict the evidence of their senses in favour of matter, being as much afraid of bodily pain from material or sensible causes as other people. The remedy for this palsy of the believing fa- culty, should consist in proposing propositions of the most simple nature to the mind, and, after gaining the assent to them, to rise to propositions of a more difficult nature. The powers of oratory sometimes awaken the torpor of the principle of faith. This was evinced, in a remarkable manner, in the speech which king Agrippa made to St, Paul, after he had heard his eloquent oration in favour of Christianity ; *' almost thou persuadest me to be a Christian." Perhaps great bodily pain would have the same, or a greater, effect in cur- ing this disorder of the mind. It has often cured paralytic affections ot the body, and of other facul- ties of the mind. Sometimes a strong passion, or emotion, by pre-occupying the mind, prevents the exercise of belief. Thus we read, that the disciples of our OF THE MIND. 275 Saviour could not believe the news of his resur- rection " for joys." In such cases the predomi- nating passion, or emotion, should be abstracted, or weakened, before an appeal is made to the prin- ciple of faith. 276 ON THE DISEASES CHAPTER XII. Of Derangement in the Memory, THIS disease is attended with die following grades : 1. There is an oblivion of names, and vocables of all kinds. 2. There is an oblivion of names and vocables, and a substitution of a word no ways related to them. Thus I knew a gentleman, afflicted with this disease, who, in calling for a knife, asked for a bushel of wheat. 3. There is an oblivion of the name of sub- stances in a vernacular language, and a facility of calling them by their proper names in a dead, or foreign language. Of this Wepfer relates three instances. They were all Germans, and yet they called the objects around them only by Latin OF THE MIND. 277 names. Dr. Johnson, when dying, forgot the words of the Lord's prayer in English but at- tempted to repeat them in Latin. Delirious per- sons from this disease in the memory often ad- dress their physicians in Latin, or in a foreign language. 4. There is an oblivion of all foreign and ac- quired languages, and a recollection only of a vernacular language. Dr. Scandella, an ingeni- ous Italian, who visited this country a few years ago, was master of the Italian, French and Eng- lish languages. In the beginning of the yellow fever, which terminated his life in the city of New York, in the autumn of 1798, he spoke English only; in the middle of his disease, he spoke French only; but on the day of his death, he spoke only in the language of his native country. 5. There is an oblivion of the sound of words, but not of the letters which compose them. I have heard of a clergyman in Newbury Port, who, in conversing with his neighbours, made it a prac- tice to spell every word that he employed to con- vey his ideas to them. 6. There is an oblivion of the mode of spelling the most familiar words. I once met with it as a 278 ON THE DISEASES premonitory symptom of palsy. It occurs in old people, and extends to an inability, in some in- stances, to remember any more of their names dian their initial letters. I once saw a will subscrib- ed in this manner, by a man in the eightieth year of his age, who, during his life, always wrote a neat and legible hand. 7. There is an oblivion of the qualities or num- bers of the most familiar objects. I know a man in this city, who has never been able to remember the difference between a jug and a pitcher ; and I know a physician, who for many years could not recollect that the umbilical cord consisted of two arteries and one vein, without associating the for- mer with the double a in the last syllable of the name of Dr, Boerhaave. There appears to be something like a palsy in the memory quoad these specific objects. 8. There is an oblivion of events, time and place, -with a perfect recollection of persons and names. This is the case with the Rev. Dr. Ma- gaw, formerly minister of St. Paul's church in this city. This disease in his memory was in- duced by a paralytic affection. OF THE MIN». 279 9. There is an oblivion of names and ideas, but not of numbers. We had a citizen of Philadel- phia, many years ago, who, in consequence of a slight paralytic disease, forgot the names of all his friends, but could designate them correctly by mentioning their ages, with which he had pre- viously made himself acquainted. 10. However strange it may appear, it has been remarked, that there is sometimes an oblivian of the most recent, the most important, and the most interesting events. Of this I could mention se- veral instances that have come within my own knowledge. One of them occurred to Dr. Priest- ly. I have ascribed the oblivion of such events, to the memory being over stimulated from an undue effort to retain them. Something similar to it occurs in the inability of lovers to dream of each other. The objects of knowledge either perish, or sleep, only in the mind. In the latter case, they are re- vived by means to be mentioned presently. Wepfer takes notice of the following symp- toms occurring with the loss or suspension of memorv. 280 ON THE DISEASES A sense of pain or heaviness in the forehead, a disposition to rub it with the hand, a formication, that is, a sense of something creeping up the left, arm, and the fingers of both hands, a disposition to weep, and an involuntary flow of urine. The causes of the weakness and loss of memo- ry are corporeal and mental. To the first belong, 1. Intemperance in eating. Suetonius tells us the Roman emperor Claudius lost his memory so entirely from this cause, that he not only forgot the names and persons to whom he wished to speak, but even what he wished to say to them. 2. Intemperance in drinking. It was from the effect of strong drink, in weakening or destroying the memory, that an old Spanish law refused to ad- mit any person to be a witness in court that had been convicted of drunkenness. 3. Excess in venery. 4. Fevers, particularly such as are of a malig- nant nature, or that affect the brain. The Rev. William Tennent, formerly the pastor of a Pres- byterian church at Freehold, in New Jersey, for. got every thing he had learned, even the letters OF THE MIND. 281 of the alphabet, in consequence of an attack of a. fever when he was about eighteen years of age. 5. Vertigo, epilepsy, palsy, and appoplexy. 6. Drying up an issue. Lassions of the brain, 7. The use of snuff. It was induced by this cause in Sir John Pringle. II. The mental causes are, 1. Grief. I once met with a woman, who had recently lost her husband and several children, who told me she forgot, at times, even her own name, 2. Terror. Artemidorus, a celebrated gram- marian, was so terrified with the sight of a croco- dile, that he immediately lost all the knowledge that he had treasured up in his memory in the course of his life. 3. Oppressing the memory in early life with words and studies disproportioned to its strength. The Latin and Greek languages, and the prema- ture application of the mind to mathematics, I n n 282 ON THE DISEASES believe, have weakened or destroyed not only me- mory, but even intellect, in many young minds. 4. The undue exercise of the memory upon any one subject often weakens it, upon all others. The famous African calculator Thomas Fuller, of Virginia, whose memory was exercised exclusive- ly upon numbers, had so little recollection of faces, that he was unable to recognize the persons who had spent hours in conversing with him, and lis- tening to his calculations, the next day after he saw them. Overcharging the memory with words has the same effect. A celebrated player in London, his son informed me, lost the recol- lection of the names of all his children, from this cause. 5. Neglecting to exercise the memory. 6. Cessation from study. Sir Isaac Newton forgot the contents of his " Principia" by ceasing to exercise his mind in study. The famous Mr. Hudde had spent several years in close application to conic sections. Leibnitz, in returning from his travels called to see him, and expected to have been highly entertained by conversing with him upon the subject of his stu- OF THE MIND. 283 dies. "Here," said Mr. Hude, sighing, "look over this manuscript. I have forgotten every thing in it since I became burgomaster of Am- sterdam." The remedies for this disease are corporeal and mental. To the First, or corporeal remedies, belong, 1. Absracting all its exciting cause. Sir John Pringle's memory was restored, in a great degree, by leaving off the use of snuff. 2. Depleting remedies, if plethora attend, and the pulse be tense or oppressed. These should be bleeding, purges, and low diet. After the re- duction of the system, the remedies should be, 3. Blisters. Wepfer speaks in high terms of their efficacy, when applied to the elbows and calves of the legs, in this disease. 4. Issues in the arms. 5. Errhines 284 ON THE DISEASES 6. Certain aromatic medicines. Etmuller says, when a young man, he greatly improved his me- mory by swallowing three or four cubebs cx^ry day. The cardamon seeds are said to have the same effect. Lavender and rosemary, or cloves may be substited for both of them. 7. The cold bath and cold weather. Milton's memory was always improved by the latter. 8. Exercise. Mr-. Pope commends a trotting horse above all things in order to excite dormant ideas. It is from the motion excited in the brain, by means of a fever, that persons in that disease, often recollect events and speak languages, which appeared to have perished in their memories. The late Mr. Frederic A. Muhlenberg inform- ed me that his father, who was for many years mi- nister of the Lutheran church in Philadelphia, in visiting the old Swedes who inhabited the south- ern district of the city upon their death beds, was much struck in hearing some of them pray in the Sweedish language, who he was sure had not spoken it for 50 or 60 years before, and who had proba- bly entirely forgotten it. It was revived by the stimulous of the fever in their brains which attend- OF THE MIND. 285 give you rest." 10. Are bodily sensibility and irritability weak- ened, or destroyed, by the protracted application of morbid stimuli to sensible and irritable parts ? The same thing takes place from the long applica- tion of vicious impressions to the moral faculties of the mind. They become, in such cases, to use the words of one of the apostles. " dead," and "seared with a red hot iron." A disease resem- bling a palsy effects them all. I might go on further, and mention, more par- ticularly, the analogy between bodily and moral diseases, and the propriety of adapting specific remedies to specific vices ; but enough I hope has been said to show the truth and importance of the subject, and the practicability of the undertaking, by persons whose professional studies and employ- ments are more nearly related to it than the au- thor's. However useful the rational and physical OF THE MIND. 365 remedies that have been mentioned may be to pre- vent or cure vice, they never can perform that work completely, without the aid of that superna- tural and mysterious remedy which it hath pleased God to unite with them in his moral government of his creatures, and that is, the forgiveness of it. In vain have legislators substituted the exter- minating axe and halter, and the influence of ig- nominious or painful corporeal punishments, for this divine mode of curing moral evil. The dan- ger and mortality of the venereal disease were en- creased, in former times, by the contempt, neglect, and corporeal chastisement, to which persons af- fected with it were exposed. Since the pain and shame of the disease have been considered as its ample punishments, and the subjects of it resto- red to public favour, the disease has every where declined, and is now rarely attended with danger, or the loss of life. The abolition of the punishment of death, and of cropping, branding, and public whipping, and substituting for them, confinement, labour, simple diet, cleanliness, and affectionate treatment, as means of reformation and forgiveness, have produced similar moral effects in the jail of Philadelphia. If this original an humane institu- tion, in which science and religion have blended theif resources together, has not been attended with uni- 366 ON THE DISEASES form success, it must be ascribed wholly to the imperfect manner with which the principles that, suggested it have been carried into effect. They have been rendered abortive, chiefly, by the crimi- nals sleeping in the same room, and by the facility and frequency with which pardons are obtained for them. The former prevents the resuscitation of conscience, and all moral and religious reflec- tion. The latter is opposed to the great axioms upon which the penal law of Pennsylvania is founded ; that " punishments should be certain, but not severe, and that a pardoning power should not be lodged in any department of a go- vernment." May this christian system of criminal jurispru- dence spread, without any of its imperfections, throughout the world! and may the rulers of na- tions learn from it, that the reformation of crimi- nals, as well as the prevention of crimes, should be the objects of all punishments, and that the latter can be effected much better by living than by dead examples! Here the reader and the author must take leave of each other. Before I retire from his sight, I shall only add, if I have not advanced, agreeably OF THE MIND. 367 to my wishes, the interests of medicine by this work, 1 hope my labours in the cause of humanity will not be alike unsuccessful ; and that the suf- ferings of our fellow creatures, from the causes that have been mentioned, may find sympathy in the bosoms, and relief from the kindness, of every person who shall think it worth while to read this history of them. T$g END^ •^braS Books, and all object! of Natural History A. E. FOOTE, M. 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