HANDBOOK OF THE HOSPITAL CORPS UNITED STATES NAVY 1939 PUBLISHED BY THE BUREAU OF MEDICINE AND SURGERY UNDER THE AUTHORITY OP THE SECRETARY OF THE NAVY UNITED STATES GOVERNMENT PRINTING OFFICE WASHINGTON : 1939 For sale by the Superintendent of Documents, Washington, D. C. - - - - Price $1.75 (Buckram) Bureau of Medicine and Surgery, Navy Department, Washington, D. July 1, 1939. The Handbook of the Hospital Corps, United States Navy, 1939, is a revised edition of the former Handbook of the Hospital Corps, United States Navy, 1930, and is compiled from articles prepared by members of the Medical, Dental, Hospital, and Nurse Corps, U. S. Navy, and reviewed and revised by Commander W. J. C. Agnew, Medical Corps, and Chief Pharmacist N. L. Saunders, U. S. Navy. It is published for the instruction and guidance of members of the Medical Department of the United States Navy and for use at the Hospital Corps Schools. The use in this volume of certain portions of the text of the United States Pharmacopoeia is by virtue of permission received from the Board of Trustees of the United States Pharmacopoeial Convention. The said Board of Trustees is not responsible for any inaccuracy of quotation nor for any errors in the statement of quantities or percentage of strengths. Permission to use for comment parts of the National Formulary, Sixth Edi- tion, in this volume has been granted by the Committee on Publications by authority of the American Pharmaceutical Association. Authority for use of New and Nonofflcial Remedies, 1935 Edition, has been granted by the American Medical Association. Ross T. McIntire. Sura eon General, U. S. Navu. Page Foreword v Chapter I. History of the Hospital Corps 1 II. Anatomy and Physiology 5 III. Section 1. Minor Surgery and First Aid 85 Section 2. Bandages and Bandaging 131 Section 3. Splints and Appliances 148 Section 4. Emergency Dental Treatment 165 IV. Section 1. Materia Medica and Therapeutics 177 Section 2. Toxicology 257 V. Section 1. Nursing 271 Section 2. Ward Management 344 Section 3. Operating Room and Surgical Technique 356 VI. Section 1. Hygiene and Sanitation 371 Section 2. Allergy 469 Section 3. Genito-urinary and Venereal Diseases 490 Section 4. Prevention op Venereal Diseases 511 Section 5. Industrial Medicine and Industrial Hazards. 514 Section 6. Field Sanitation 521 Section 7. Duty With Marine Corps Expeditionary Forces. _ 564 Section 8. Landing Force 570 Section 9. Shore Patrol 574 VII. Diets and Messing for the Sick 679 VIII. Pharmacy 599 IX. Chemistry 643 X. Anaesthesia 735 XL Section 1. Administration and General Clerical Pro- cedures 749 Section 2. Hospital Supplies and Property Account- ability 774 Section 3. Commissary Supervision 804 Section 4. Deaths and Medico-Legal Matters 833 XII. Hospital Corps Technical Specialties. Section 1. Aviation Medicine 847 Section 2. Basal Metabolism „ 849 Section 3. Blood Grouping and Matching 856 Section 4. Chemical Warfare 862 Section 5. Diving and Submarine Duty 872 Section 6. Electrocardiography 879 Section 7. Embalming ; 882 Section 8. Independent Duty 887 Section 9. Laboratory Procedures and Technique 889 Section 10. Physical Therapy 917 Section 11. Recruiting - 936 Section 12. X-ray 940 Index 969 TABLE OF CONTENTS FOREWORD In this 1939 edition of the Handbook of the Hospital Corps, U. S. Navy, the subject matter has been revised, enlarged, and brought up-to-date, as nearly as possible, with the sciences which are briefly discussed in the various chapters and sections. The handbook is intended to serve as a general guide and reference book for the hospital corpsmen of the Navy, especially those performing duty independ- ent of medical officers, and as a textbook for their instruction in the Hospital Corps Schools and elsewhere. It contains information and instructions con- cerning the duties of the Hospital Corps of the Navy, but hospital corpsmen, particularly those in the upper ratings, are urged to make frequent reference to the U. S. Navy Regulations, the Manual of the Medical Department, U. S. Navy, the manuals of other Navy Department bureaus, circular letters, etc., for additional information and instructions. The principal subjects have been arranged in the order in which they occur in examinations for advancement in rating. As these subjects necessarily are presented in epitomized form, readers of the handbook should realize that the information contained in it must be supplemented by reference to the standard textbooks and professional journals usually available in the medical libraries of hospitals, ships, and stations. The Bureau of Medicine and Surgery herewith expresses appreciation to the following-named members of the Medical Department, U. S. Navy for the time and effort spent in preparing, reviewing, and revising the material for this book: Captain J. Harper, (MC), U. S. Navy — Commander G. B. McArthur, (MC), U. S. Navy Anatomy and Physiology. Commander M. D. Willcutts, (MC), IT. S. Navy_ Minor Surgery and First Aid. Bandages and Bandaging. Captain H. E. Harvey, (DC), U. S. Navy Captain W. L. Darnall, (DC), U. S. Navy Commander R. S. Davis, (DC), U. S. Navy Emergency Dental Treatment. Materia Medica and Therapeu- tics. Pharmacy. Chief Pharmacist E. G. Swann, U. S. Navy—- Chief Pharmacist A. T. Schwartz, U. S, Navy_ Pharmacist P. S. Gault, U. S. Navy •Toxicology. Chief Nurse J. Ferris, U. S. Navy Nursing. Chief Nurse P. W. Hoyle, U. S. Navy Ward Management. Commander G. A. Eckert, (MC), U. S. Navy_ Operating Room and Surgical Technique. Hygiene and Sanitation. Prevention of Venereal Diseases. Lieutenant O. L. Burton, (MC), U. S. Navy Lieut. Commander F. M. Rohow, (MC), U. S. Navy Allergy. Commander M. S. Mathis, (MC), U. S. Navy— Genito-urinary and Venereal Diseases. VI FOREWORD Commander H. L.*Shinn, (MC), U. S. Navy— Industrial Medicine and Indus- trial Hazards. Captain AV. L. Mann, (MC), U. S. Navy Field Sanitation. Commander W. T. Brown, (MC), U. S. Navy— Duty with Marine Corps Expe- ditionary Forces. Commander L. D. Arbuckle, (MC), U. S. Navy- 'Landing Force. Shore Patrol. Nurse R. Dunbar, U. S. Navy Diets and Messing for the Sick. Lieut. Commander 0. L. Bozarth, (MO), U. S. Navy Pharmacist’s mate second class, J. F. Reid, U. S. Navy >Chemistry. Captain F. L. Conklin, (MC), U. S'. Navy Anaesthesia. Chief Pharmacist N. L. Saunders, U. S. Navy__ Administration and General Clerical Procedures. Division of Finance, Bureau of Medicine and Surgery. Hospital Supplies and Property Accountability. Chief Pharmacist J. H. Bell, U. S. Navy Commissary Supervision. Captain C. W. O. Bunker, (MO), U. S. Navy— Chief Pharmacist R. Aikman, U. S. Navy Deaths and Medico-Legal Mat- ters. Commander J. C. Adams, (MC), U. S. Navy Aviation Medicine. Commander J. M. McCants, (MC), U. S. Navy_ Basal Metabolism. Commander H. E. Ragle, (MC), U. S. Navy Blood Grouping and Matching. Commander B. H. Adams, (MC), U. S. Navy— Chemical Warfare. Commander F. S. Johnson, (MC), U. S. Navy Diving and Submarine Duty. Captain C. R. Baker, (MC), U. S. Navy Electrocadiography. Embalming. (Based on the Manual of the Medical De- partment, U. S. Navy.) Chief Pharmacist O. P. Dean, U. S. Navy Independent Duty. Commander O. Wildman, (MC), U. S. Navy Laboratory Procedures and Technique. Lieutenant O. C. Welch, (MO), U. S. Navy Physical Therapy. Captain G. E. Thomas, (MC), U. S. Navy Recruiting. Commander W. A. Fort, (MO), U. S. Navy Commander F. W. Muller, (MC), U. S. Navy- X-ray. Appreciation and thanks are herewith expressed for the courtesy of the American Red Gross, the General Electric X-ray Corporation, and the follow- ing publishers in permitting the reproduction and use of certain illustrations appearing in this book: William Wood & Co., for figures 8, 9, 12, 15, 17, 18, 24, 27, 30, 32, 33, 37, 41, 47, and 52; Lea and Febiger for figures 10, 11, 16, 29, 40, 44, 56, 66, 67, 69, 70, 71, 77, 78, 81, and 123; W. B. Saunders & Co., for figures 49, 50, 57, 65, and 147; P. Blakiston’s Son & Co., for figures 13, 14, 20, 23, 48, 124, 137, 138, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, and 178; J. B. Lippincott & Co., for figures 72, 146, and 148; and The Macmillan Co., for figure 153. The courtesy of the Medical Department, U. S. Army in permitting use of the text of and the reproduction and use of the illustrations in the Manual of Splints and Appliances of the U. S. Army, is acknowledged. The assistance of Pharmacist’s mate first class 0. E. Otwell, Jr., U. S. Navy, in preparing the index and typewriting much of the manuscript and of Chief Pharmacist’s mate, J. A. McCalley, U. S. Navy, and Pharmacist’s mate third class M. J. Hadden, U. S. Navy, in preparing a number of the sketches and illustra- tions is acknowledged. CHAPTER I HISTORY OF THE HOSPITAL CORPS OF THE UNITED STATES NAVY Prior to 1898 the duties attendant upon the care of the sick and injured of the Naval Establishment were performed by certain individuals whose appointment or enlistment was provided for from time to time, under various designations and titles, by order of the Navy Department. In the earliest days of the Navy, afloat, the care of the sick and injured devolved upon the surgeon and the surgeon’s mate, with the assistance of such members of the crew as were detailed to help in emergencies. An act of Congress, approved March 2, 1799, provided: “A convenient place shall be set apart for the sick and hurt men, to which they are to be removed * * * and some of the crew shall be appointed to attend them, and keep the place clean.” The place assigned on board ships for the care of the sick, in accordance with the above act, was usually referred to as the “cockpit” and in later years it was designated as the “sickbay.” The “loblolly boy” was the title designating the man or boy first specifi- cally detailed to assist in the care of the sick and injured. The name probably originated in the British Navy, as it appears in some of the early writings on that service. The first oflicial use of the title in the United States Navy appears in the Naval Regulations published in 1814 where it is stated: “The loblolly boy is to serve the surgeon and surgeon’s mate.” The following is quoted from United States Naval Regulations, 1818: “The surgeon shall be allowed a faithful attendant to issue, under his direction, all supplies and provisions and hospital stores, and to attend the prepara- tion of nourishment for the sick. “The surgeon’s mates shall be particularly careful in directing the loblolly boy to keep the cockpit clean, and every article therein belonging to the Med- ical Department. “The surgeon shall prescribe for casual cases on the gun deck every morn- ing at 9 o’clock, due notice having been previously given by his loblolly boy by the ringing of a bell.” The loblolly boy was succeeded by a male “nurse” in accordance with a general order of the Navy Department of June 16, 1861, which stated: “There shall be allowed to each vessel commissioned for sea service, with a comple- ment of less than two hundred, one nurse, and with two hundred and over two nurses * * * to be appointed by the surgeon and approved by the commander of the ship, and to be borne upon the ship’s books for special service upon the sick.” About the year 1873 the title of “bayman” came into use, and this title was recognized officially in the United States Naval Regulations published in 1876, and it remained in effect until the organization of the Hospital Corps of the Navy in 1898. Daymen were enlisted as landsmen for general service, and rated bayman by the commanding officer on the recommendation of the surgeon, or senior inedical officer. The number was regulated by the complement of the vessel. 2 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The record of the advent of surgeon’s stewards in the Navy is more or less obscure, but this seems to have been shortly after the Bureau of Medicine and Surgery was established in 1842. The following is an extract from a letter found in the old files of the bureau under date of May 5, 1843. “A circular' is now under consideration to allow a surgeon’s steward to all hospitals and vessels, without necessity to sign articles, but to be appointed.” The Medical Journal of the U. S. S. Rapidan, 1844, bears a notation that an applicant for surgeon’s steward was found disqualified for appointment on account of physical disability. Originally surgeon’s stewards were enlisted as landsmen or seamen, and were appointed by the commanding officer on the recommendation of the surgeon of the vessel. They were classed as petty officers and could be dis- rated for incompetency or misbehavior. By general order of the Navy Department, November 11, 1861, their status was changed to “appointed petty officer”; appointments were made for the “duration of the cruise” and they were subject to discharge for misbehavior, “the fact of misbehavior to be established by a summary court.” The title of surgeon’s steward was changed to apothecary by circular order of the Navy Department, dated December 8, 1866. This order reads: “The designation of persons serving as surgeon’s steward is changed to that of apothecary, and they will be appointed for duty in the Medical Department of the Navy, ashore and afloat, in the same manner as surgeon’s stewards have heretofore been appointed. Apothecaries of the first class will rank with boatswains, * * *, Apothecaries of the second class will rank with boat- swain’s mates in charge, * * *, Apothecaries of the third class will rank with boatswain’s mates.” United States Naval Regulations, 1893, article 1683, prescribed that: “Apothecaries for shore stations shall, with the approval of the Secretary of the Navy, be appointed by the Chief of the Bureau of Medicine and Surgery.” United States Naval Regulations, 1896, article 797, prescribed that: “A candidate for examination and first enlistment as apothecary must be a gradu- ate of some recognized college of pharmacy.” The title of “apothecary” was changed to “hospital steward” by act of Congress of June 17, 1898. The Hospital Corps of the United States Navy came into existence as an organized unit of the Medical Department under the provisions of an act of Congress, approved June 17, 1898. This act established the grade of pharmacist, and the ratings of hospital steward, hospital apprentice, first class, and hospital apprentice; provided for appointments to the grade of pharmacist, and the enlisted ratings; fixed the pay and allowances; and specified the duties to be performed. An act of Congress, approved August 22, 1912, provided that pharmacists after 6 years from date of warrant and after satisfactorily passing the pre- scribed examination should be commissioned chief pharmacists, and when so commissioned, have the rank, pay, and allowances of a chief boatswain. The present organization of the Hospital Corps is in accordance with an act of Congress, approved August 29, 1916, and it is considered of sufficient importance, as a matter of general information to all hospital corpsmen, to quote the text of this act relating to the Hospital Corps in full. “Hereafter the authorized strength of the Hospital Corps of the Navy shall equal three and one-half percentum of the authorized enlisted strength of the Navy and Marine Corps, and shall be in addition thereto, and as soon as the neces- sary transfers or appointments may be effected the Hospital Corps of the United HISTORY OF THE HOSPITAL CORPS 3 States Navy shall consist of the following grades and ratings: Chief pharmacists, pharmacists, and enlisted men classified as chief pharmacist’s mates; pharmacist’s mates, first class; pharmacist’s mates, second class; pharmacist’s mates, third class; hospital apprentices, first class; and hospital apprentices, second class; such classifications in enlisted ratings to correspond respectively to the en- listed ratings, seaman branch, of chief petty officers; petty officers, first class; petty officers, second class; petty officers, third class; seaman, first class; and seaman, second class: Provided, That enlisted men of other ratings in the Navy and in the Marine Corps shall be eligible for transfer to the Hospital Corps, and men of that corps to other ratings in the Navy and the Marine Corps. “The President may hereafter, from time to time, appoint as many phar- macists as may be deemed necessary, from the rating of chief pharmacist’s mate, subject to such moral, physical, and professional examinations and re- quirements as to length of service as the Secretary of the Navy may prescribe; Provided, That the pharmacists now in the Hospital Corps of the United States Navy or hereafter appointed therein in accordance with the provisions of this act shall have the same rank, pay, and allowances as are now or may hereafter be allowed other warrant officers. “Pharmacists shall, after 6 years from the date of warrant, be commissioned chief pharmacists after passing satisfactorily such examinations as the Secre- tary of the Navy may prescribe, and shall, when so commissioned, have the same rank, pay, and allowances as now or may hereafter be allowed other commissioned warrant officers: Provided, That the pharmacists at present in the service who have served or may hereafter serve 6 or more years in that grade shall be eligible for promotion to the grade of chief pharmacist upon satisfactorily passing the examinations provided for in this act. “The Secretary of the Navy is hereby empowered to limit and fix the numbers in the various ratings. “Section three of an act entitled ‘An act to organize a Hospital Corps of the Navy of the United States; to define its duties and regulate its pay,’ approved June seventeenth, eighteen hundred and ninety-eight, be, and the same is hereby, repealed, and the pay, allowances, and emoluments of the enlisted men of the Hospital Corps shall be the same as are now, or may hereafter be, allowed for respective corresponding ratings, except the rating of turret captain of the first class in the seaman branch of the Navy: Provided, That the pay of the rating of the chief pharmacist’s mate shall be the same as that now allowed for the existing rating of hospital steward. “Hospital and ambulance service with such commands and at such places as may be prescribed by the Secretary of the Navy, shall be performed by members of said corps, and the corps shall be a constituent part of the Medical Department of the Navy; and the enlisted men thereof shall be a part of the enlisted force provided by law for the Navy. “Officers and enlisted men of the Medical Department of the Navy, serving with a body of marines detached for service with the Army in accordance with the provisions of section sixteen hundred and twenty-one of the Revised Statutes, shall, while so serving, be subject to the rules and articles of war prescribed for the government of the Army in the same manner as the officers and men of the Marine Corps while so serving.” CHAPTER II ANATOMY AND PHYSIOLOGY General introduction. If the hospital corpsman is to intelligently perform his duties in caring for the sick and injured he must not only have a good, general knowledge of the structure of the human body but he must also know considerable about the complicated mechanism that constitutes human life. In this chapter human anatomy and some simple physiology will be presented in as brief a way as is consistent with providing the elementary information which the hospital corpsman needs in his work and a ready source to which he can turn for study and review. Between the structure and function of the various parts of the body there exists an intimate relationship that cannot possibly be covered in an abridged chapter such as this must necessarily be. For the hospital corpsman in whom there is aroused a real interest in the anatomy and physiology of the human body fuller text-books must be consulted and studied. In this chapter anatomy will be discussed more completely than physiology, the discussion of which will principally concern the essentials of function. All objects existing in Nature are commonly classified into three grand divisions or groups called the animal, vegetable, and mineral kingdoms. Ob- jects in the mineral kingdom are without life, are known as inorganic, and are made up of inorganic matter. Objects belonging to the animal and the vegeta- ble kingdoms are known as organic, are made up of organic matter, and possess life, that quality or character which distinguishes an animal or a plant from inorganic or from dead organic bodies. By organic matter is implied the organization or arrangement of materials in the way that can be accomplished only through the processes of life. Any living thing, whether animal or vegetable, is spoken of as an organism. Animal organisms are distinguished from vegetable organisms by fundamental differences in their processes of life. Stated in a very general way, vegetable life builds up substances in the organism from water vapors and carbon diox- ide in the air and from solutions of mineral salts in the soil, while animal life absorbs complex substances such as proteins and carbohydrates and brings about their oxidation in the organism with absorbed oxygen. Animal organ- isms possess the attributes of sensation and voluntary motion, while vegetable organisms, though exhibiting irritability in response to stimuli, are generally without voluntary motion or true sense perception; animal organisms receive and digest solid food in an internal cavity previous to its absorption and use, while vegetable organisms make their own food from simple raw materials and utilize it directly within the tissues of the organism; at least part of the food required by animal organisms must be protein matter derived from the bodies of other animal organisms or from vegetable organisms; the life proc- esses of an animal organism must be such that oxygen is absorbed and carbon dioxide produced during its life. The building up of substances in the vegetable organism, or plant, from simple raw materials, is a process dependent on the presence of a green-colored pigment called chlorophyll in the plant and on the radiant energy of the sun. 6 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY In a chemical sense this process, which is known as photosynthesis, is one of reduction. At the same time synthesis, or reconstruction, takes place, and two of the products of the process are proteins and carbohydrates, both of which are required in the life processes of animal organisms. The oxidation of substances in the animal organisms, or animal, is, chemi- cally, a decomposition process, and two of the products are carbon dioxide and water vapor, both of which are required in the life processes of plants. For this process the presence of absorbed oxygen in the animal is necessary. The animal uses portions of plants, either dead or alive, to obtain proteins and carbohydrates. These it decomposes and returns to the air and soil as animal waste products in the form of carbon dioxide and water. The plant, through its green coloring matter and the light rays of the sun, recovers the carbon dioxide and water, synthesizes them into proteins and carbohydrates, and at the same time returns oxygen to the air. It is therefore quite evident that the life processes of plants and animals are closely related and necessary to each other. The life processes of animals and plants are largely chemical in nature and are proceeding continually in living cells. They are concerned in the building up and destruction of protoplasm, the essential substance of living cells, inci- dental to the manifestation of vital phenomena, and when considered collec- tively are spoken of as metaholism. The living organisms called animals are classified according to their natural relationships, the organization of their bodies, and their characteristics or attributes. In this classification the division of vertebrates (those with a backbone) stands first, and the highest class of vertebrate animals is that known as the mammalia (those which nourish their young with milk). One of the members of the class of mammalia is man, considered to be the highest type of animal existing or known to have existed. Of all animals man is the only one possessing the power of articulate speech and it is largely because of this power that man has the capacity of abstract reasoning, the extraordinary mental development that is the most characteristic difference be- tween man and other animals. Man is commonly spoken of as a human, or a human being, and it is the structure and life processes of the human being that will be dealt with in this chapter. The human body is composed of a combination of several systems of organs contained within a supporting framework and the whole surrounded with an external covering. The systems of organs fulfill special functions and are di- vided into their component tissues which are collections of the fundamental life unit, the animal cell. The study of the human body is divided into a number of closely related sciences which are named according to the structures or parts of the body with which they deal. Broadly speaking, anatomy is the science which treats of the structure of animals or plants. General anatomy deals with the tissues and their properties regardless of the organs into which they are formed. Because the characters of these tissues are to be made out only with the aid of the microscope, general anatomy is practically synonymous with histology. Gross anatomy deals only with the structures and characters discernible with the naked eye. Human anatomy is the study of the structure of the body of man and the relation of its parts, one to another. It is divided into descriptive anatomy, which deals with the character, form, size, and position of organs and parts, surgical anatomy, which treats of the situation and relative position of organs and parts as affecting their liability to injury and their accessibility to surgi- cal operations, and topographical anatomy, which treats of the anatomy of par- ANATOMY AND PHYSIOLOGY 7 ticuiar regions or parts of the body with reference to medical diagnosis and to surgery. It may be divided also into osteology, arthrology, myology, neurology, angiology, and splanchnology, or the anatomy of the systems of the body. Physiology is the study of the functions and activities of the various parts and organs of living bodies, and is sometimes described as “the physics and chemistry of living matter.” It is that branch of the science of biology which deals with the processes, activities, and phenomena incidental to and character- istic of life or of living organisms. These processes and phenomena include many that are chemical, physical, and mechanical, as well as others apparently of a peculiar nature, but those which are purely mental are not usually included in the ordinary scope of physiology, being considered under psychology, the science of mind. Embryology is the study of the origin and development of the body and its organs. Histology is the study of the minute structure of the normal tissues of the body. It is sometimes called microscopical anatomy and is a synonym for general anatomy. Pathology is the study of the changes in structure and function of the various parts and organs of the living body that occur in disease. Biology is the general study of all forms of life. In its broadest sense it in- cludes botany, the science of vegetable life, zoology, the science of animal life, cytology, the science of cell-formation and cell-life, anatomy, physiology, and allied sciences. It involves the study of the origin, development, structure, functions, and distribution of plants and animals, and the more generally occurring phenomena accompanying their life, growth, and reproduction. As man is but a complex animal organism it becomes apparent that in studying human anatomy and physiology one is but studying branches of general biology, and a real understanding of human anatomy and physiology must be prefaced by some knowledge of elementary biological principles. Certain of those prin- ciples have been very briefly discussed in the paragraphs pertaining to living organisms and their life processes, and the fundamental unit of life, the cell, will next be considered. The cell is the structural unit of which animals and plants are built up. Usually microscopic in size, it consists of a small mass of protoplasm called the cell body, or cytoplasm, in which is a smaller body of modified protoplasm called the nucleus, and is enclosed in a more or less resistant outer covering, the cell wall. The cell wall in animal cells, when present, is usually of soft, nitrogenous material, while in plant cells it is composed almost wholly of cel- lulose. The hard parts of animal tissues are materials secreted by the cells and are not a part of the cells. Protoplasm is the viscid, jelly-like material which constitutes the essential substance of living cells and upon which all the vital functions of nutrition, secretion, growth, reproduction, irritability, and motility depend. It is regarded as the only form of matter in which, or by which, the phenomena of life are manifested, and is hence often called the physical basis of life. The simplest forms of both animal and vegetable life are made up of only one cell. Yeast and bacteria are unicellular vegetable organisms; the amoeba is a unicellular animal organism. In an organism composed of only one cell that cell must necessarily have the full variety of characteristics that will enable it to carry out all the processes of life of the organism. Such a cell is called a simple cell, an unspecialized or undifferentiated cell. An organism so constituted reproduces by a simple and equal division of its cell into two cells, each of which grows and is capable of again dividing. 8 HANDBOOK OF THE HOSPITAL COUPS, U. S. NAYY Cells vary in the shape, size and structure of the protoplasm, in the shape, size and location, and sometimes in the number, of the nucleus within the cell, and in staining qualities. In more complex forms of life the single organism is made up of many cells with varying characteristics. Certain groups of cells are specialized to per- form special functions, one group specialized in performing one function, other groups differentiated to perform other special functions, with consequent varia- tions in structure and composition. In a given organism masses or groups of specialized cells similar in structure and function are called tissues. A delimited mass of highly specialized tissue is termed an organ. The human body is made up of animal cells, all of which, with the exception of the red blood cells, consist of the cytoplasm, nucleus, and usually the cell wall. The nucleus is highly specialized in structure and function, is enclosed in a delicate membrane, and inside of it is a network of material called chromatin. In the cytoplasm and near the nucleus is a minute structure called the centrosome which is concerned with the changes which take place when the cell reproduces (fig. 1). Figure 1.—Simple animal cell. (U. S. Naval Medical School.) The cell wall, or plasma membrane, when present as a distinct layer, is a very thin, condensed film surrounding the cytoplasm, from which it differs in some way. Frequently it can be recognized only because certain substances can and others cannot penetrate it. Animal cells all are able to grow and mature, they can be stimulated into activity, which property is known as irritability or excitability, and they can reproduce. It is known that protoplasm consists chiefly of proteins, salts, and water, and for the growth of cells these substances must be supplied in a form that can be absorbed and used. A fluid called tissue fluid, which is derived mainly from the blood and contains the food substances required, bathes the cells and is their source of nutrition. If for any reason they are deprived of tissue fluid cells cease to grow and die. After reaching maturity cells may remain indefinitely in that state or may reproduce. Cell irritability may be caused by mechanical, chemical, and nervous forms of stimulation, the action of heat and light, etc. Singly, the cause is called a stimulus, collectively, they are called stimuli. The result of cell stimulation may be noted as a movement or alteration of the shape of the cell, as in ANATOMY AND PHYSIOLOGY 9 muscular movements, by the liberation of substances secreted by the cell, as in the flow of digestive juices, and in other ways. The stimuli exciting the cell into activity usually are the impulses carried by nerves to the cell, or the action of chemical substances which reach the cell from the blood through the tissue fluid. The reproduction of cells in the human body occurs during the period when the organ or tissue of which the cell is a part is growing and lasts until the maximum growth of the whole body has been reached. After that cells may reproduce to replace those destroyed by injury or disease or that have become worn out. Cell reproduction takes place by the parent cell dividing equally into two daughter cells. Each daughter cell contains half the substances in the parent cell and exhibits all the properties of the parent cell. It is thought that new cells inherit the characteristics of the parent cell through the chromatin in the nucleus. When a cell reproduces by division the process begins by the chromatin in the nucleus elongating into structures called chromosomes and the centrosome near the nucleus developing two star-shaped structures called asters, each of which has a central mass that becomes the centrosome in the new cell, and radiating fibers called aster rays. The fibers between the two central masses of the asters begin to form a structure shaped like and called a spindle, the membrane enclosing the nucleus bursts and the chromosomes become attached to the fibers of the spindle. By the time development of the spindle is completed the chromosomes have been drawn into the equator of the spindle and begun to split into equal halves. The halves then separate and the spindle begins to divide at its equator, the chromosomes group themselves at the spindle poles, the aster rays disappear, and the cell body begins to divide. When division of the cell body is finished two new cells have been formed and the process of reproduction is complete (fig. 2). Cell reproduction by this form of division in which there are extensive preliminary changes in the nucleus is known as mitosis or mitotic division. Bacteria reproduce by a simpler form of division called amitosis or amitotic division, which is also called fission. In man the parent cell is known as the ovum, or egg. After leaving the ovary of the mother the ovum unites with the male germ cell or spermatozoon, and the union is called the fertilization of the ovum. Immediately after this union cell reproduction begins. The fertilized ovum divides into 2 daughter cells, which then divide to make 4, the 4 to make 8, £he 8 to make 16, etc. As this division or segmentation goes on, there occurs a gradual differentiation in the cells produced, so that there are cells of several different types, each capable of re- producing others of its kind. Through this process of fertilization, segmenta- tion, differentiation, and growth there is finally, brought about the complex animal organism known as man. In a preceding paragraph it was stated that when the life processes of animals and plants are considered collectively they are spoken of as metab- olism. In these life processes the cells are involved. During periods of cell activity certain parts of the cellular substance become broken down, or destroyed or decomposed. This is sometimes spoken of as destructive metabolism but is usually called katabolism. To replace the loss or repair the breakdown of cellular substance the cell takes up nutrient material in a process called assimilation and uses it to build up new protoplasm by the process known as anabolism. Tissues, as stated before, are masses or groups of specialized cells similar in structure and function. Tissues have their own characteristic intercellular 10 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Hft00tN-S9 Figure 2.—Cell reproduction by mitotic division. 1, Normal cell before commencement of process of reproduction showing network of chromatin in nucleus, and adjacent centro- some; 2, Chromatin elongated into chromosomes and centrosome developing asters and aster rays; 3, Nuclear membrane broken, spindle developing, and chromosomes attached to spindle fibers; 4, Spindle fully developed, with chromosomes in equator; 5, Chromo- somes splitting into halves; 6, Chromosomes separated and spindle beginning to divide at equator; 7, Chromosomes grouped at spindle poles, aster rays disappearing and cell body beginning to divide; 8, Cell body divided and reproduction process complete with two daughter cells formed. (U. S. Naval Medical School.) ANATOMY AND PHYSIOLOGY 11 substance which joins the cells in it together. Although a tissue may be modi- fied by situation it can always be identified when studied microscopically. The tissues in the adult human body are usually classified into five main groups: 1. Epithelial tissue; 2. Connective tissue; 3. Muscular tissue; 4. Blood and lymph; and 5. Nervous tissue. Each tissue is characterized by certain peculiarities of structure and function. The free surface of the skin, the linings of the digestive, respiratory, and urinary tracts, the linings of blood and lymph vessels and serous cavities, and certain important secreting glands as the liver, kidneys, etc., are made up of epithelial tissue, or epithelium (fig. 3). Having such different services to per- form the cells in epithelial tissue are generally di- vided according to ar- rangement and shape into five principal classes as cuboidal, columnar, flat, squamous, and ciliated. and according to function into glandular or secret- ing, and protective. The epithelium forming the various linings spoken of is commonly known as endothelium. When the cells are arranged in single layers epithelial tissue is called simple and when they are arranged in distinct layers one above another it is called strati- fied. Unlike other tissues the cells in epithelial tissue are joined together by thickened lymph in- stead of intercellular sub- stance. The epithelial cells known as ciliated have hair-like appendanges on their free edges whose function is to propel fluid or particles. These ciliated cells also are generally columnar. Other epithelial cells can produce the viscid substance called mucus and the tissues where these cells are located are known as mucous membranes. Connective tissue is the supporting tissue of the body and has a general dis- tribution (fig. 4). In this tissue the cells are scanty and the intercellular substance is considerable. The principal forms of connective tissue are: 1. Adipose, or fat, in which fat-cells are lodged in meshes of areolar tissue and fat replaces most of the cytoplasm; 2. Areolar, found beneath the skin and between muscle fibers and also called loose fibrous, in which the cells are enmeshed in a loose network of delicate, elastic fibers interlacing in every direction; 3. Cartilaginous, often called gristle, in which the cells lie in cavi- ties of an intercellular substance called the matrix which may be finely granular and translucent, be mixed with white fibrous tissue, or contain a network of yellow elastic fibers; 4. Elastic, found in the trachea and bronchi. Figure 3.—Epithelial tissue. a, Cuboidal; h, ciliated columnar; c, flat; d, stratified squamous. (U. S. Naval Medical School.) 154294°—39 2 12 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the inner coats of blood vessels, and elsewhere in the body, in which the inter- cellular substance consists of yellow, elastic fibers branching and uniting with one another; 5. Fibrous, found in tendons and ligaments and also called dense fibrous, in which the intercellular substance consists of bundles of closely Hftooetf-s<3 Figure 4.—Connective tissue, a, Adipose ; l>, areolar; c, cartilaginous ; d, elastic; e, fibrous. (U. S. Naval Medical School.) packed parallel white fibers bound firmly together and with some areolar tissue between the bundles; 6. Lymphoid, found in the tonsils, spleen, and lymphatic glands and also called reticular, in which the intercellular substance is largely fluid and consists of a loose network of white fibers containing lymphoid cells; and 7. Osseous, in which the intercellular substance is in ANATOMY AND PHYSIOLOGY 13 layers and may be regarded as white fibrous tissue in which calcium and other- mineral salts have been deposited and made it very hard. Muscular tissue is the tissue of which muscles are formed (fig. 5). It is composed of cells which have been modified and elongated to form thread-like muscle fibers held together by delicate connective tissue. Muscle fibers have a reddish color, are lightly covered by elastic, connective-tissue sheaths, are bound together in bundles or fasciculi by delicate connective-tissue envelopes, and those bundles grouped together into larger bundles or sheets to form, various muscles. Muscular tissue has the following properties: Irritability, or response to stimulations usually received from nerves; contractility, the power to become shorter and thicker; tonicity, a mild, sustained contraction giving the skeletal muscles firmness and maintaining a slight steady pull on their attachments; and extensibility, ability to be stretched. Muscular tissue is of three distinct types and the characteristics of each are imparted to the muscles they form. The muscles of the skeleton are known as striated, striped, or voluntary, and Figure 5.—Muscular tissue, a, Striated; 6, nonstriated; c, cardiac. (U. S. Naval Medical School.) the individual cells of this type are elongated, multinuclear, contain transverse striations peculiar to them, and can be controlled by the will; the muscles of hollow internal organs, blood vessels, etc., are known as nonstriated, unstriped, or involuntary, and the individual cells are plain, flattened, without striations, and cannot be controlled by the will; the muscle of the heart is known as cardiac, striated or striped but involuntary, and has short, mononucleated cells which branch and unite with adjacent cells, and have striations which are different from those in the skeletal muscles. Blood and lymph may be considered as tissues consisting of free cells in a fluid intercellular substance which does not join the cells together. Nervous tissue, composed of nerve cells, nerve fibers, and an intercellular supporting tissue, is the most highly specialized tissue in the body and will be discussed more fully in the section dealing with the nervous system. Having discussed the masses or groups of cells called tissues the delimited, or bounded, masses of tissues termed organs will next be briefly considered. An organ is that part or structure in an animal organism which is adapted for the performance of some specific function, or functions, as the heart, the kidneys, etc. In most multicellular organisms, as in man, the essential and active part of an organ is made up of the particular form of specialized tissue on which the function of the organ depends, while other tissues serve for the support, nutrition, control, etc., of the organ. Groups of organs which act together and collectively have a common function in contributing toward one of the more important and complex vital functions are known as systems, as the digestive system, the nervous system, etc. 14 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In order to understand anatomical descriptions the meaning of the following words should be known: Anterior, in front; posterior, to the back; superior, higher; inferior, lower; internal, within, inside; external, outside; lateral, at the side; medial, median, in the middle; ventral, the abdominal side; dorsal, on the back; proximal, nearest to a point; distal, farthest from a point. THE BONES AND JOINTS Osteology is the study of the structure of bones. It also includes the study of the cartilages and ligaments which bind bones together. Arthrology or syndes- mology is the study of the joints or articula- tions. It takes into con- sideration the parts forming the joints and the mechanism of each joint. The skeleton is the bony framework of the body (fig. 6). Its func- tion is to support and give shape to the body, to protect certain vital organs, to afford attach- ments for tendons, mus- cles, and ligaments, and to act as joined levers by which movements may be accomplished. Bone, or osseous tis- sue, has been stated to be one of the connective tissues in which there are deposits of calcium and other mineral salts. These salts normally constitute about 67 per cent of the weight of bone but their amount increases as the body ages with the result that bones become harder and more brittle. By dissolv- ing out the mineral salts or inorganic matter in bone by means of dilute mineral acid an organic substance called ossein remains, and this substance, which is perfectly flexible, can be bent and twisted without difficulty. Bones consist of a hard, outer shell called the compact tissue, and an inner, spongy, and porous part called cancellous tissue. In long bones a cavity called the medullary canal extends the whole length of the shaft. This cavity and 1. Cranium'. 2. Vertebral column. 3. Clavicle. 6. Scapula. 4. Ribs. 5. Sternum. 7. Humerus. 8. Radius. 9. Ulna. 10. Carpus. 11. Metacarpus. 12. Phalanges. 14. Femur. 15. Patella. 16. Tibia. 17. Fibula. 18. Tarsus. 13. Pelvis. 19. Metatarsus. 20. Phalanges. Figuee 6.—The skeleton. (Manual of Instruction, Royal Naval Sick Berth Staff.) ttMJM ANATOMY AND PHYSIOLOGY 15 the spaces in the cancellous tissue are filled with a substance called marrow which is of two types, yellow and red. Yellow marrow is composed chiefly of fat; red marrow contains little fat but is abundantly supplied with blood and in it are also found reddish-colored, nucleated cells called erythroblasts from which red blood cells are formed. The ends and facets of bones are covered with a special variety of cartilage which is called articular cartilage and forms the articulating surfaces and enters into the formation of joints. Those parts of bones not covered by articular cartilage are covered with a thin, vascular membrane of fibrous tissue called periosteum which, when it reaches the articular cartilage, continues as the perichondrium, a fibrous connective tissue covering the surface of the cartilage. Periosteum has the power of generating new bone and does so in the normal growth of bone or when the original bone has been destroyed. Bones are nourished from capil- laries in the periosteum which dip down into small pits on the bone surface and from small arteries, one or more to each bone, which enter through small openings called nutrient foramince and branch out into the marrow and bone tissue, passing through the compact tissue in small passages called canals, those located in the center of concentric rings of compact tissue being known as Haversian canals (fig. 7). Bones are classified by shape as: Long, which have two extremities and a shaft of compact tissue, thickest in the middle where the bone is the most slender and the strain the greatest, and containing the central medul- lary canal, as the femur, the humerus, etc.; short, which are small, irregularly shaped, and made of cancellous tissue throughout except for a thin layer of compact tissue covering the surface, as the bones of the wrist and the ankles; flat, which have broad or elongated flat plates of compact tissue enclosing a vari- able amount of cancellous tissue and afford extensive protection and broad sur- faces for the attachment of muscles, as some of the bones of the skull, the ster- num, the shoulder blades, and the pelvic bones; and irregular, which cannot be placed in any of the other classes because of their peculiar shape and consist largely of cancellous tissue with a thin layer of compact tissue covering the sur- face, as the vertebrae, the mandible, the hyoid. Two hundred and six distinct bones make up the skeleton of the adult. In the child there are more, some of which fuse together during growth. In the table following no sesamoid bones (small bones developed in tendons at points of much pressure) except the patellae are included. Figure 7.—Transverse section of compact tissue of bone, showing concentric rings and Haversian canals. Magnified about 150 diameters. (Sbarpey.) The Bones of the Skeleton Bones of the skull 22 Bones of the ears (auditory ossicles) 6 Hyoid bone 1 Bones of the vertebral column 26 The sternum 1 The ribs 24 Bones of the upper extremities 64 Bones of the lower extremities (including the patellae) 62 Total 206 16 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The meaning of the following words used in describing bones should be known: Process, a prominence; tuberosity, a large process; tubercle, a small process; spine, a sharp, slender process; condyle, a rounded, knuckle-like process; crest, a narrow ridge; bead, a portion of bone supported on a con- stricted part or neck; fossa, a depression or pit, a cavity; notch, a deep inden- tation ; groove, a furrow or channel; sinus, a cavity within a bone; antrum, a hollow space in a bone; foramen, a perforation or opening; fissure, a groove. The bones. The skull is the bony framework of the head, is elliptical in- shape, and Is commonly divided into two parts, the cranium and the face (tig. 8). The cranium is made up of various flat bones which are united in irregular lines called sutures, and form the cranial cavity which is more or less oval in shape and in life holds the brain. The upper wall of this cavity is called the vault of the skull; the floor is called the base of the skull and has three distinct fossa; or hol- lows, the anterior cranial fossa, the posterior cranial fossa, and the middle cranial fossa. In the base of the skull are many small foramina; for the passage of nerves and blood vessels to and from the brain. Just posterior to its mid- dle the base has a large round opening, the foramen magnum, through which the spinal cord, its coverings, certain cranial nerves, and the vertebral arteries emerge. In front and below the cranium are the bones of the face which form two orbital cavities, one on each side of the root of the nose, for the eyes, the nasal cavity for the passages of the nose, and the oral cavity for the mouth. When the skull is viewed from the side there is seen, just behind the orbital cavity of the eye, a broad depression, the temporal fossa, the whole area of which in life affords attachment for the temporal muscle, which closes the jaw. The temporal fossa is limited below by a bony arch, the zygomatic arch, or zygoma. Just below and posterior to the zygomatic arch is an opening leading into the bone, the external auditory canal, below and behind which is a bony prominence called the mastoid process. This contains the mastoid air cells, the seat of the inflammation in mastoid disease. Viewing the skull from below, the foramen magnum is seen just posterior to the middle with an articular surface on either side for articulation with the atlas, the first cervical vertebra. Anteriorly on either side are the zygo- matic arches, and directly in front, bordered on three sides by the teeth of the upper jaw, is the roof of the oral cavity, the hard palate. Just above the hard palate and opening backward are the posterior nasal apertures. Figure 8.-—Skull: a, Nasal bones; b, superior maxilla; c, mandible; d, occipital bone; e, temporal bone; f, parietal bone; g, frontal bone. (Mason.) ANATOMY AND PHYSIOLOGY 17 The Bones of the Cranium Occipital 1 Frontal 1 Parietal 2 Temporal 2 Sphenoid 1 Ethmoid 1 Bones of the ear 3X2=6 Total 14 The occipital bone forms the posterior part of the vault and the posterior fossa of the base. It contains the foramen magnum. The frontal bone is the bone of the forehead and forms the whole anterior part of the vault. At its lower anterior border it extends abruptly backward on either side to form the roof of the orbital cavity and at the same time the very front part of the floor of the cranial cavity. Just internal to the upper orbital margin on either side it contains large air cells, the frontal sinuses, which have openings leading into the nasal cavity. The parietal bones articulate with each other in the mid-line, with the occipital behind and the frontal in front, thus completing the upper part of the vault. The temporal bones are located one on each side of the base. Each has a squamous (flat, scale-like) portion extending upward to form a part of the side of the vault and at the same time a part of the floor of the temporal fossa. A process extends forward to form the zygomatic arch, and posteriorly, extend- ing downward, is the heavy mastoid process. Extending inward and forming a large part of the floor of the middle fossa of the base is the petrous (stony hard) portion of the bone. This portion contains the organ of hearing and the external auditory canal leading into the ear. Each middle ear contains three small bones named from their shape, malleus (hammer), incus (anvil), and stapes (stirrup). The sphenoid lies in the base of the skull, between the frontal bone in front, the occipital bone behind, and the temporal bone at either side and behind. The ethmoid lies anterior to the sphenoid. One part of the bone forms a small portion of the floor of the anterior fossa, lying in the mid-line between the orbital parts of the frontal bone. From this part three processes extend downward—a perpendicular plate in the mid-line to form the upper part of the nasal septum, and a process on each side to form the upper lateral wall of the nasal cavity. The Bones of the Face Maxillae 2 Palate bones 2 Vomer 1 Inferior turbinated bones . 2 Nasal bones 2 Lacrimal bones T 2 Malar or zygomatic bones 2 Mandible 1 Hyoid /— 1 Total 15 18 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The two maxillae unite to form the upper jaw. In the body of each is a large air cell, the maxillary sinus or antrum of Highmore. The lower border of the bone is the alveolar process and in this the upper teeth are embedded. Running horizontally inward from just above the alveolar process is a thin plate of bone that unites with its fellow of the opposite side to form all but the very posterior part of the hard palate. Above the hard palate the medial aspect of the bone forms the lateral wall of the nasal cavity. Each palate bone is L-shaped, the horizontal part forming the posterior por- tion of the hard palate and the vertical part forming the lower posterior portion of the lateral wall of the nasal cavity. The vomer is a thin flat bone that forms the lower posterior part of the nasal septum. The inferior turbinated bones are two small shell-like bones, lying along each lower lateral wall of the nasal cavity, forming a sort of curved shelf. The nasal bones are two small flat pieces of bone, one on each side of the root of the nose, that join in the mid- line to form the bridge of the nose. The lacrimal bones are two small bones that form a part of the wall of the orbital cavity at its inner and lower angle, one on each side. The malar bones are the cheek bones and underlie the most prominent part of the cheek. The mandible is the horseshoe shaped bone of the lower jaw. The horizontal part of the bone is called the body, and the upper part of the body, which supports the teeth, is called the alveolar process. The vertical part of the bone on each side is called the ramus. The juncture of the ramus and the body is called the angle of the jaw. Each ramus is topped by two processes—the condyloid process behind, for articulation with the temporal bone, and the coronoid process in front, for the insertion of the temporal muscle. The hyoid bone is a small U-shaped bone lying anteriorly in the neck and serving for the attachment of various muscles of the throat and tongue. The Bones of the Neck and Trunk Vertebrae (true) 24 Sacrum 1 Coccyx 1 Sternum 1 Ribs 24 Total 51 The spinal column consists of 24 movable or true verte- brae, the sacrum and the coccyx (fig. 9). Each of the latter two hones are made up of vertebral segments (false or fixed vertebrae) that are fused in adult life. The true vertebrae are irregular bones placed one on top of another with cartilage between, and named according to their location. There are 7 cervical, 12 thoracic or dorsal and 5 lumbar vertebrae. Piguee 9.—Spinal col- umn : a, Cervical; h, dorsal; c, lumbar ; d, sacrum ; e, coccyx. (Mason.) ANATOMY AND PHYSIOLOGY 19 The form of the individual vertebrae, at different levels, varies somewhat, but a typical vertebra may be described as consisting of a body, cylindrical in form; a vertebral arch, enclosing the vertebral foramen; and three processes that act as levers for the attachment of muscles. These three processes spring from the vertebral arch—one on each side, the transverse process, and one posteriorly, the spinous process (fig. 10). The spinous process may be felt underneath the skin in the mid-line of the back. There are four articular processes that also spring from the arch. The sacrum is roughly triangular in shape and is formed by the fusion of five false vertebrae. It articulates on each side with a hip bone to form, with the coccyx, the posterior wall of the pelvis. The coccyx is the lower extremity of the spinal column and consists of four, sometimes five, verte- bral segments fused together. It corresponds to the tail of lower animals. The thorax is a conical elongated bony cage formed by the sternum and costal cartilages in front, the 12 ribs on each side, and the bodies of the 12 thoracic vertebrae behind. It contains and protects the principal organs of circulation and respiration (fig. 11). The sternum occupies the middle of the upper part of the chest wall in front. It is divided into an upper part, the manubrium, a small lower part, the xiphoid process, and between these a body. It articulates above with the clavicles and on each side with the cartilages of the first seven ribs. The ribs, of which there are 12 pairs, form a series of curved bony bands that support the chest wall. Behind, they artic- ulate wfith the thoracic vertebrae. In front, each rib is provided with a costal cartilage. The first seven ribs articulate with the sternum by means of their cartilages and are called true ribs. The lower 5 ribs are not supported and are called false ribs. The eighth, ninth, and tenth are united by their cartilages to the cartilages of the seventh, while the last 2 are free at their anterior ends and are called floating ribs. The Bones of an Upper Extremity Clavicle 1 Scapula.. 1 Humerus 1 Ulna 1 Radius . 1 Carpal bones 8 Metacarpal bones 5 Phalanges 14 Total 32X2=64 Figure 10.—Seventh cervi- cal vertebra. (Gray.) Figure 11.—The thorax. Ventral view. (Gray.) 20 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The clavicle (collar bone) consists of a rounded curved shaft with enlarged ends. Medially it articulates with the sternum and laterally with the acromion process of the scapula (fig. 12). The scapula (shoulder blade) is a flat bone of roughly triangular shape. From its posterior surface there springs a shelf-like process, the spine. At the outer end of the spine is the acromion process, with an articular facet for the clavicle. At the extreme lateral root of the spine is a constriction of the upper lateral angle of the bone. This constric- tion is the neck, and beyond it is the head. The head supports the glenoid cavity, for articulation with the head of the humerus, and above this is a beak- like projection, the coracoid process (fig. 13). The| humerus is the bone of the arm (fig. 14). It articulates proximally with the glenoid cavity of the scapula and distally with the ulna and the radius. It is made up of a head, an anatomical neck, a surgical neck, a shaft, and a distal extremity. The distal extremity has on each side a prominence, the medial and the lateral epicondyles. Below these are two articular facets, one for the ulna and one for the radius. The ulna is placed on the medial side (little-finger side) of the forearm (fig. 15). It is a long bone, much larger at its proximal end, where it has a promi- ment process, the olecranon. This forms the point of the elbow. The ulna articulates with the radius at both ends and with the humerus proximally. At its very distal extremity is a styloid process, which can be felt beneath the skin on the inside of the wrist. Figure 12.—The clavicle. (Mason.) Figure 13.—Posterior aspect of right scapula. (Potter.) Figure 14.—Humerus. (Potter.) Figure 15.—Radius and ulna. (Ma- son.) The radius is placed on the lateral side (thumb side) of the forearm (fig. 15). It is a long bone, much larger below than above. It articulates above with the humerus and the ulna and below with the carpal bones and the ulna. On its lower end it has a styloid process that can be felt beneath the skin on the outside of the wrist, ANATOMY AND PHYSIOLOGY 21 The carpal bones are small six-sided bones arranged in the wrist or carpus in two rows. The distal row, or row nearest the finger tips, contains, beginning from the radial side of the wrist, the greater multangular, lesser multangular, capitate, and hamate bones. The proximal row, or row nearest the elbow, con- tains, beginning from the radial side of the wrist, the navicular, lunate, trian- gular, and pisiform bones. The metacarpal bones are located in the palm. The proximal end of each is called the base and it articulates with the carpus. The shaft extends through the palm, and the head, or distal end, articulates with the proximal phalanx of the corresponding digit. The metacarpals are numbered from 1 to 5, beginning at the thumb side. There are three phalanges in each finger and two in the thumb. The phalanx at the end of the digit is called the distal phalanx, the one next to the hand the proximal phalanx, and the one between, the middle phalanx. The Bones of a Lower Extremity Innominate bone 1 Femur 1 Patella 1 Tibia , 1 Fibula 1 Metatarsal bones 5 Tarsal bones 7 Phalanges 14 Total 31X2=62 The innominate bone (hip bone) is made up of three parts, the ilium, the ischium, and the pubis. In adult life these three parts are fused together. The pubis lies below and in front, joining with the pubic part of the opposite bone to form the symphysis pubis. The ischium lies below and to the back, while above and posteriorly is the large flat portion of the bone, the ilium. At its central part the bone is heavy and on its outer aspect there is a deep cavity, the acetab- ulum, for articula- lation with the head of the femur. Just below the ace- tabulum is a large opening, the obturator foramen. Poste- riorly the iliac portion of each bone articulates with the sacrum, and, with coccyx, forms the pelvis (fig. 16). The femur is the bone of the thigh and the longest bone of the body (fig. 17). It is composed of a proximal end, a distal end, and a shaft. The proximal end is made up of a head, a neck, and two processes called the greater and lesser trochanters. The head fits into the acetabulum to form the hip joint. The distal end is made up of two condyles which articulate with the tibia. The patella, a sesamoid bone, overlies the front of the knee joint and is in the tendon of the quadriceps muscle. Figure 16.—Pelvis (adult.) (Gray.) Figure 17.—Femur. (Mason.) 22 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The tibia, or shin bone, is the larger of the two bones of the leg and it lies to the inner side (fig. 18). The proximal end of the bone has the medial and lateral condyles for articulation with the femur. The lateral side of the outer condyle articulates with the fibula. The distal extremity is smaller than the proximal. Medially it presents a prominence, the internal malleolus, distally an articular surface for the talus, and laterally a smaller articular surface for the fibula. The fibula is the slender bone lying on the outer side of the leg (fig. 18). It has two enlarged ends. The upper end articulates with the tibia alone. The lower end articu- lates with the tibia and also with the talus. The outer prominent portion of the lower end of the bone is called the lateral malleolus. It can be felt beneath the skin. There are seven tarsal bones in each ankle, the talus, which articulates with the tibia and fibula to form the ankle joint, the calcaneus, the heel bone, the navicular, a boat-shaped bone; the first, second, and third cuneiform, and the cuboid bones. The metatarsal bones are similar to the metacarpal but are slightly longer and heavier. The phalanges of the toes are similar to those of the fingers but are shorter. The joints. Joints, or articulations, are the connections by which the various bones of the skeleton come together. There are two types of joints, the immovable, whose object is to preserve the rigidity of the bones joined together, and the movable, whose object is to permit movement of the bones joined together, and which may be either freely or partly movable. The best example of the immov- able joint is in the skull where the bones are “dovetailed” together; the hip and shoulder joints are examples of freely movable joints; and the articulations of the pubic bones in the pelvis and the lower ends of the tibia and fibula are examples of partly movable joints. The substances which enter into the formation of joints vary with the character of the joint. In every joint there are two or more skeletal elements (bone or cartilage) and a uniting substance or medium, the amount and kind of which depends on the type of the joint. The uniting substance in immov- able joints is a very thin layer of fibrous tissue which corresponds to and is continuous with the periosteum, or is of cartilage, while in movable joints it is fibrous and fibrocartilaginous material, and cartilage. Movable joints have a cavity separating the bones entering into them. Cartilage covers the articulating surfaces of the bones in movable joints and in some joints there are also discs of cartilage in the joint cavities. The bones entering into the joint are held together by strong bands of fibrous tissue called ligaments, which pass from one bone to the other on every side of the joint and form a capsule which is the external boundary of the joint cavity. This fibrous capsule is lined with synovial membrane which secretes a substance called synovial fluid that is retained in the cavity and serves to lubricate the joint (fig. 19). According to their type of movement, movable joints are known as gliding, as those between the articular processes of the vertebrae, hinge, as the elbow, knee, finger, and toe joints, ball and socket, in which the round head of one bone fits into a cup-like cavity in another as in the hip and shoulder joints, rotary, in which one bone rotates on one which is stationary, as the first and Figure 18.—Tibia and fibula. (Mason.) ANATOMY AND PHYSIOLOGY 23 HAOOE.N-39 Figure 19.—Anterior, a, posterior, 6, and lateral, c, views of left knee joint ; d, schem'a of a movable joint showing; 1, capsular ligaments ; 2, articular cartilages continuous with periosteum ; 3, disc; and 4, spaces lined with synovial membrane and containing synovial fluid. 24 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY second vertebrae, and condyloid, in which an oval head fits into a shallow ellip- tical cavity, as in the joints between the fingers and the hand. Joints permit movements of the skeletal parts with each other. These move- ments are accomplished by means of the muscles and the kinds of movement are as follows: Flexion—Bending, as in raising the forearm on the arm. Extension—Straightening or unbending. Abduction—Moving away from the mid-line of the body. Adduction—Moving toward the mid-line of the body. Rotation—Turning on its own axis, as in turning the head. Peonation—Turning downward, as in turning the palm of the hand downward. Supination—Turning upward, as in turning the palm of the hand upward. Eversion—Turning outward. Inversion—Turning inward. Myology is the study of the structure and functions of muscles. Muscles are structures composed chiefly of muscular tissue and all motion of any sort in the body, whether conscious or unconscious, is due to the action of muscles. They constitute a large part of the fleshy portions of the body, enter into the structures of many of the internal organs, form from 40 to 50 per cent of the body weight, and vary in shape according to the work they have to do. All the muscles attached to the bones of the skeleton are of the voluntary type and are termed skeletal muscles. Those used in breathing, while ordinarily acting without conscious effort of the will, may be controlled and breathing accelerated, slowed, or stopped, as desired. A typical skeletal muscle consists of a fleshy mass of parallel bundles of muscle fibers bound together by a sheath of fibrous tissue called the epimysium, each bundle or fasciculus of fibers be- ing surrounded by a delicate connective-tissue envelope called the perimysium, and each fiber being lightly covered by an elastic, connective-tissue sheath called the sarcolemma. At the ends of the muscle the epimysium and the perimysium unite with the tendons by which the muscle is attached to the bone. The attachment of a skeletal muscle which is fixed or stationary during use is known as the origin and the one which moves as the insertion. Many muscles have an insertion far from the fleshy belly. Tendons are made up of closely packed, parallel bundles of nonelastic, dense fibrous tissue, with a very small amount of areolar tissue separating the bundles. They unite with the periosteum of bones to form secure attachments of muscles and differ in shape in different muscles, some being round and thick while others are flat and thin. When tendons are of the latter shape they are called aponeuroses. Their lack of bulk makes their presence about joints desirable as joint movements are easier accomplished than if bulky muscles were present. Muscles seldom act alone and the performance of a very simple motion is usually due to the action of a whole group of muscles. Muscles and groups of muscles are named according to the type of motion they produce, as the extensor muscles of the hand, and the adductor muscles of the thigh, and for each group of muscles that produces one type of motion there is another group that produces the opposite type of motion. To keep muscles in position and place during movement they are held together by layers of areolar tissue called fascia}. The fasciae vary in density, structure, and thickness, in some places forming considerable masses, and are of two types called superficial and deep. The superficial type lies immediately beneath the skin and usually contains consider- able fat. Blood and lymph vessels and nerves of the skin are also found in THE MUSCLES ANATOMY AND PHYSIOLOGY 25 Figure 20.—Superficial muscles of the body. (After Brubaker.) 26 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY it. The deep type Is dense and tough and in addition to covering muscles, covers delicate and specialized structures such as organs and blood vessels. In many places sheets of it lie between adjacent groups of muscles thereby per- mitting the different groups to act independently and still remain in place. Each muscle has a nerve supply and it is usually through the action of its nerve that a muscle is brought into activity and its action coordinated with that of other muscles. Such a nerve is called a motor nerve and if one is destroyed by disease or injury the muscle usually becomes inactive and wastes away. In addition to the norm'al stimulation of muscles through their nerves, they may also be activated by mechanical, chemical, or electrical stimulation of the muscles themselves, and by the application of heat and cold. When a muscle contracts it uses a certain amount of energy to do a certain amount of work. In doing this work the protoplasm in the muscle cells breaks down and chemical waste products, which are toxic, are produced. If these waste products accumulate the phenomena of fatigue result, and in some cases muscular cramps may occur. To supply the energy required and restore the muscle protoplasm, carbohydrates are taken from the blood and oxidized in the muscle. During contraction, or work, carbon dioxide and water are formed by oxidation, and removed by the blood which also brings the oxygen necessary for the restoration of muscle protoplasm. In ordinary activities the blood supply to muscles is increased, thereby increasing the supply of food materials, carrying away waste products more quickly, and enabling the muscles to build up and restore their efficiency. When-muscle substance dies it becomes solid and rigid, and loses its power to react to stimulation. The stiffening and hardening of the muscles after death is due to this phenomenon, which is called rigor mortis. The muscles of the body are divided into the following groups: those of the head and face; of the neck; of the trunk, which is subdivided into those of chest, thorax, abdomen, back and perineum; those of the upper extremity; and those of the lower extremity (fig. 20). The muscles of the head and face consist of numerous groups of small muscles which act in the movements of the eyes, the face, the scalp and assist in mastication, deglutition, talking and expression. The muscles oi the neck move the head from side to side, backward and forward, and rotate it. Some of these muscles act as auxiliary muscles of respiration, assist in deglutition, in speaking, and in other complicated move- ments of the head and neck. The muscles of the hack are divided into five layers, the superficial layer and four deep layers. They act on the spinal column to keep the trunk in an erect posture, and permit movements from side to side, forward and back- ward, and a moderate amount of turning. Those of the chest and thorax, including the diaphragm, the great muscle which separates the thoracic and the abdominal cavities, are chiefly respiratory muscles. These muscles, with the exception of the diaphragm, assist in movements of the trunk, the neck and the upper extremities. The muscles of the abdomen are the external oblique, the internal oblique, the rectus abdominis, and the transversus abdo- minis. The rectus abdominis is a paired muscle situated on each side of the median line of the abdomen within the fibrous aponeurosis of the oblique muscles. It extends from the symphysis pubis to the thoracic wall. These muscles form the sides and front of the abdominal wall. They assist in mictu- rition and defecation by compressing the abdominal viscerse. They also assist in respiration and emesis, flex the thorax on the pelvis and aid in lateral flexion and rotation of the spine. HAD0£(V_59 Figure 21—ANTERIOR VIEW OF RELATION OF SKELETAL MUSCLES TO SKELETON (U. S. Naval Medical School) hAOOEW .39 FIGURE 22—POSTERIOR VIEW OF RELATION OF SKELETAL MUSCLES TO SKELETON (U. S. Naval medical School) A 1ST ATOMY AND PHYSIOLOGY 27 The inguinal ligament (Poupart’s) is a thickened band of fibers of the aponeurosis of the external oblique muscle, extending from the anterior superior spine of the ilium to the spine of the pubis. Just above this ligament and parallel to it is the inguinal canal through which pass the spermatic cord in the male, and the round ligament of the uterus in the female. The inner opening in the transversus muscle is called the internal inguinal ring; the outer opening in the tendon of the external oblique muscle is called the external inguinal ring. These openings form weak places in the abdominal wall, and are the frequent sites of a protrusion of parts of the viscera which is called a hernia or rupture. Other weak places are the umbilicus, and the femoral ring which serves as a passage for the blood vessels to the lower extremity. The muscles of the perineum are those surrounding the base of the repro- ductive organs and the rectum and form the floor of the pelvis. Their action is to assist in micturition and deflation. The muscles of the upper extremity are divided into those of the shoulder, which act to move that joint; those of the arm; those of the forearm; and those of the hand. The muscles on the front of the arm flex the forearm; those on the back extend it. The same principle applies generally to the muscles which arise from the bones of the forearm and are attached to the bones of the hands or fingers. Some of these muscles however act to pronate the hand (turn palmar surface down) and others to supinate the hand (turn the palmar surface up). The muscles of the palm and the back of the hand, flex, extend, adduct, abduct and circumduct the fingers and the thumbs. The muscles of the lower extremity are divided into those of the hip; the thigh; the leg; and the foot. The muscles on the anterior side of the hip flex the thigh on the abdomen, those on the posterior extend, those on the medial side adduct and those on the lateral side abduct. Combinations of these actions produce circumduction of the lower extremity. The muscles of the posterior portion of the thigh flex the leg on the thigh. Those of the anterior portion extend the leg. The muscles having origin on the anterior surface and on the posterior surface of the bones of the leg, flex, ex- tend, and circumduct the foot. The muscles of the dorsal and the ventral sur- faces of the foot extend and flex the toes respectively. It is not possible to present a complete study of the individual skeletal muscles in this chapter, but to show the way they should be studied a few that form important anatomical landmarks and typify the action of muscles in general will be individually described. The temporal muscle. Origin: From the whole area of the temporal fossa. Insertion; The coronoid process of the mandible. The muscle is fan-shaped, and its principal action is to close the jaw. The sternocleidomastoid muscle is an important landmark in the neck and can be easily demonstrated by bending the head forward and to the opposite side. Origin: The manubrium of the sternum and the medial third of the upper surface of the clavicle. Insertion: The mastoid process of the temporal bone. Action: When acting alone flexes head laterally and rotates it to the opposite side. Both acting together bend the head forward. (If muscles in the back of the neck hold the head extended they may act as extraordinary muscles of inspiration by raising the sternum and the clavicles.) 154294°—39 3 28 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The biceps muscle is located on the front of the arm. Origin: By two heads, which accounts for its name. The tendon of the short head is attached to the tip of the coracoid process. The tendon of the long head is attached just above the upper rim of the glenoid cavity and passes through the capsule of the shoulder joint. Insertion: By a tendon which attaches to the tubercle of the radius. Action: Draws the arm forward, flexes the elbow, and supinates the forearm. The triceps muscle is located on the back of the arm. Origin: By three heads, hence its name; the long head from the scapula, the lateral head from the upper part of the humerus, and the medial head from the lower posterior surface of the humerus. Insertion: By a tendon to the olecranon process of the ulna. Action: To extend the elbow and to adduct the arm. The deltoid muscle forms the prominence of the shoulder. Origin: From the lateral part of the shoulder girdle. Insertion: The outer surface of the shaft of the humerus at about its middle (the deltoid tuberosity). Action: To raise (abduct) the arm. The diaphragm is the muscular wall which separates the abdominal cavity from the thoracic cavity. It is vaulted upward. Its fibers arise from the bony cartilaginous chest wall, converge, and are inserted into the fibrous central por- tion. When the fibers contract they pull the central portion downward. SPECIAL MEMBRANES AND GLANDS IN GENERAL A membrane is an enveloping or lining tissue of the body. The chief mem- branes are classified as: Serous, synovial, mucous and cutaneous. Serous membranes are thin, transparent, fairly strong and elastic. Their surfaces are moistened by a fluid resembling serum. They are found lining closed cavities and passages which do not communicate with the exterior. These membranes consist of two layers; the endothelium, a modified epithelium, and the corium, a thin layer of fibrous tissue and blood and lymph vessels. They are divided into the following three classes: Serous membranes proper, which consist of a closed sac, one part of which is attached to the walls of the cavity which it lines, and the other reflected over the surface of the organs contained in that cavity. This class includes the pleurae, which cover the lungs and line the thoracic cavity; the pericardium which covers the heart; the peritoneum which lines the abdominal wall, and clothes its contained viscera; the lining membrane of the vascular system; the internal coat of the heart, blood vessels and lymphatics; the capsule of Tenon, back of the eyeball; and the arachnoid coat of the meninges. The serous mem- branes serve as a protective covering by forming a smooth slippery lining and secreting a serum which acts as a lubricating fluid. Synovial membranes are associated with joints and muscles and secrete a viscid glairy fluid called synovial or joint fluid. These membranes are articu- lar, which surround and lubricate the joints; vaginal, which form the sheaths of tendons abont some joints; and bursal, which form simple sacs interposed between soft tissue and bone. The latter may be deep seated between muscle or tendon and bone, or superficial between skin and bone, for example, the patellar bursae. Mucous membranes line the cavities which communicate with the exterior. Their surfaces are coated over and protected by mucus. The mucous membranes of the body may be divided into the gastro-pulmonary, and the genito-urinary. ANATOMY AND PHYSIOLOGY 29 The gastro-pulmonary mucous membrane covers the inside of the alimentary tract and the air passages and all cavities communicating with them. This includes the accessory sinuses of the nose; the lacrimal ducts; the conjunctiva; the auditory canals, including the middle ear and the mastoid cells; the common bile duct; the gall bladder; the biliary duets; the pancreatic duct; and the sali- vary ducts. The genito-urinary mucous membrane furnishes the inside lining of the urethra; the bladder; the ureters; the pelvis and tubules of the kidney; and all of the genital ducts including the prostatic, the seminal and the ductus deferens. Cutaneous membrane is the external covering of the body, or skin. Its structure and functions will be discussed later. A gland is an organ which secretes something essential to the system or excretes waste materials the retention of which would be injurious to the body. Glands are of three types: Simple, compound, and ductless. Simple glands are generally tubular or sacular in structure and open to the surface by a single duct, their secretions being thrown directly onto a free surface. Com- pound glands are glands the structure of which is subdivided into smaller tubu- lar or sacular structures which open by smaller ducts into a main duct. Their structure may be compared to a bunch of grapes, the branching stem of which corresponds to the ducts of the gland and the grapes to the groups of gland tissue called lobules. The secretions of compound glands are carried off through their ducts. Ductless glands are glandular structures which have no ducts and whose secretions are discharged directly into the blood or lymph. THE BLOOD AND THE BLOOD VASCULAR SYSTEM Blood is the fluid tissue which is contained and circulates in the blood vascu- lar system of the body. This system consists of the heart, arteries, capillaries, and veins, and in it the blood is kept circulating by the force of the heart beat. In the adult the quantity of blood is estimated to be about one-thirteenth of the body weight or about 6 quarts in an average adult weighing 160 pounds. It is a reddish colored, viscid, opaque fluid slightly heavier than water, normally having a specific gravity averaging 'about 1.055 and a slightly alkaline reaction. In composition blood consists of a fluid portion, the plasma or blood plasma, in which are suspended the “formed elements,” the red blood cells, the white blood cells, and the blood platelets. The blood cells are also known as blood corpuscles and the blood platelets as thrombocytes. In blood the cells are not joined together by intercellular substance as in other tissues but float freely in the plasma. The functions of the blood are numerous and all are important and neces- sary to the well-being of the body. In performing its functions blood: 1. Serves as a medium for the exchange of gases, carrying oxygen to the tissue cells and removing carbon dioxide from them; 2. Serves as a medium for the interchange of nutritive and waste mate- rials, carrying food materials absorbed from the digestive tract to the tissue cells and removing waste materials from them for elimination by the excretory organs; 3. Serves as a medium for the transmission of hormones; 4. Aids in equalizing and maintaining body temperature; 5. Aids in protecting the body against infection by contributing cellular and body-fluid factors to the defense mechanism of the body known as immunity; 6. Guards against hsemorrhage by clotting when shed; and 7. Maintains the all-important acid-base equilibrium or balance of the body. 30 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Healthy blood (plasma and blood cells) consists of about 78 per cent water and 22 per cent solids, and contains a great variety of substances, most of which are found in the plasma. Blood plasma is the fluid portion of the blood and when free from blood cells is a clear, straw-colored liquid having a specific gravity of about 1.026 and a slightly alkaline reaction. The term blood plasma should not be confused with the term blood serum for the two terms refer to quite different sub- stances, Blood plasma is the liquid part of blood before coagulation takes place. When blood escapes from its vessels it usually coagulates, or clots, and as the clot forms it generally shrinks and squeezes out a clear, yellowish liquid known as blood serum, which may be defined as the liquid part of blood after coagulation takes place. By filtration the plasma passes through the walls of the capillaries into the tissues where it is known as lymph. The composition of blood plasma is about 90 to 92 per cent water and about 8 to 9 per cent solids. In addition to water its constituents may be listed as follows: 1. Gases: Oxygen, carbon dioxide, and nitrogen ; 2. Proteins: Fibrinogen, globulins, albumins, and cell proteins, excluding haemoglobin; 3. Pigments: Haemoglobin, in red blood cells, bilirubin, in serum, etc.; 4. Nonprotein nitrogenous bodies: Urea, uric acid, creatine, creatinine, am- ino acids, ammonium salts, and an unidentified fraction; 5. Nonnitrogenous bodies: Sugar, lactates, phenols, chlolesterol and “lipoids” such as fats, soaps, and the phosphatides (phospholipoids) ; together with the intermediate products of fat metabolism (“acetone bodies”) ; 6. Inorganic salts: The chlorides, carbonates, sulfates, and phosphates of sodium, potassium, calcium, magnesium, and iron; 7. Enzymes and antienzymes: Glycolase, lipase, enterase, oxidase, antipro- tease, etc.; and 8. Special substances: Hormones, immune bodies, opsonins, complement, etc. Acid-base equilibrium. The normal metabolic processes of the body result in the continuous produc- tion of acid end-products which tend to alter the reaction of the blood when added to it, i. e., make it less alkaline. Oxidation in all tissues produces carbon dioxide which has acid properties, muscular activity produces lactic acid, and sulfuric and phosphoric acids are formed in the oxidation of proteins containing sulfur and phosphorus. In spite of such acid substances being constantly added to the blood its slightly alkaline reaction remains remarkably uniform and constant because the physiological activities of the body are so adjusted that variations in the reaction are kept within narrow limits. The maximum varia- tion in reaction that is not dangerous to life is only eight-tenths of a point. Keeping the alkaline reaction of the blood within those limits is known as maintaining the acid-base equilibrium or balance and is accomplished by neutralization of the acid products as soon as they are formed in the tissues, by the prompt elimination of excess acid through the regulating action of the lungs and kidneys, and by the presence in the blood of substances called buffers. A buffer is any substance which when present in a solution tends to prevent the reaction of the solution from changing on the addition of acid or alkali. All buffers are mixtures of a weak acid and its basic salts, or a weak base and its acid salts, and among the substances present in the blood which act as buffers carbonic acid and its bicarbonate salts and haemoglobin and its basic salts ANATOMY AND PHYSIOLOGY 31 are of chief importance; proteins in the plasma have some buffer action, and also the phosphates. The action of buffers in maintaining the acid-base equilibrium is a very com- plicated process and only a brief explanation can be given here. This action, which is spoken of as buffering, depends on the presence of substances in the blood and tissues which convert strong acids into weaker ones by chemical reaction. One of these substances is sodium, an alkali, which reacts chemi- cally with weak acids such as carbonic acid and phosphoric acid, and with proteins to form the alkaline salts sodium bicarbonate, sodium phosphate, and the sodium salts of the proteins. These salts in turn react with stronger acids to form sodium salts of the stronger acids and at the same time liberate the weaker acids. In this way the effect of the stronger acids is greatly weakened and there is prevented an increase in acidity which would tend to make the reaction of the blood less alkaline. The combination of sodium with a weak acid, mainly as sodium bicarbonate, constitutes the principal buffering mechanism of the blood, and the amount of sodium that is so combined and available for use in neutralizing stronger acids is spoken of as the alkali reserve. The principal acid added to the blood as the result of the metabolic processes in the body is carbonic acid, considerable of which is formed when carbon dioxide enters the blood from the tissues. As soon as this acid is formed most of it combines with the sodium chloride present in the blood plasma and forms sodium bicarbonate, the remainder diffuses into the red blood cells where it unites with the potassium present as potassium hsemoglobinate and forms potassium bicarbonate. The chlorine liberated in the formation of sodium bicarbonate passes to the red blood cells where it combines with the luemoglobin. The result of these reactions is an increase in the amount of bicarbonates available for the neutralization of acids. On reaching the lungs the blood becomes oxygenated or purified and the haemoglobin gives up the chlorine it had taken up. The liberated chlorine passes into the blood-plasma, reacts with the sodium bicarbonate to form sodium chloride and liberates carbon dioxide which is exhaled. Should there be any tendency toward an increase in the acidity of the blood such as would follow an increase in carbon dioxide the respiratory center is stimulated and respiration becomes more rapid with consequent increased elimination of carbon dioxide. As the neutralization of acids cannot be accomplished without lowering the alkali reserve and as acids are constantly being added to the body in foods and by the acids formed within the body, to prevent lowering the alkali re- serve to a point where it is dangerous it is necessary to eliminate the acids without losing a corresponding amount of alkali, or base. This is largely done through the secretory and excretory functions of the kidneys, which play an important part in maintaining the normal acid-base balance or equilibrium of the blood by excreting the excess of acids above the normal equilibrium. The normal acid reaction of urine as compared with the slightly alkaline reaction of blood is due to the selective ability of the kidneys to excrete weak acids and acid salts and at tlfe same time hold back a large part of the alkali base with which they are combined in the blood. The part which is held back is used to replenish the alkali reserve. Acid elimination takes place through the kidneys principally in the form of acid phosphates, and in some conditions as much as 50 per cent of the acid excreted may be free acid. Should the alkali base begin to be depleted in spite of this excretion of acid the kidneys break up urea which is accompanied by the production of ammonia. 32 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The ammonia so formed is then used instead of alkali base to neutralize much of the acid excreted which appears hi the form of ammonium salts. Even strong acids like hydrochloric and sulfuric are sometimes excreted as ammonium salts. This neutralizing mechanism may be so overtaxed or its activities so dis- turbed by the ingestion of unusual amounts of acid or alkali or as a result of disease that there occurs a noticeable change in the reaction of the blood and resulting conditions known as acidosis or alkalosis. Any marked change of reaction is fatal unless quickly corrected or compensated. Acid-base equilibrium or balance is also discussed in the section on Labora- tory Procedures and Technique. Immunity. The body possesses a defense mechanism termed immunity by which it can resist and overcome infection. (See section on Hygiene and Sanitation.) By immunity is meant the ability of the body to protect itself against injury by harmful bacteria or by the poisonous products of bacteria called toxins. In this defense mechanism the blood and lymph play an important part. The protec- tive function of the blood in immunity is partly due to the blood plasma and partly to the white blood cells. Any substance which, when injected into an organism, is capable of stimu- lating the production of a substance antagonistic to the substance injected is known as an antigen, and the substance produced is known as an antibody. When foreign substances such as bacteria or their toxins enter the blood they act as antigens and stimulate the production in the blood plasma of specifically antagonistic antibodies. There are various types of antibodies and they are usually designated according to the maimer in which they act against the invad- ing substance. Some of the more important types are known as bacteriolysins, which kill the bacteria themselves, agglutinins, which cause the bacteria to settle together in clumps, precipitins, which cause precipitation of the bacteria, and antitoxins, which neutralize the poisons produced by bacteria. Also produced in the blood plasma are substances called opsonins which so change bacteria that they can be more easily ingested by the white blood cells. Through their power of amoeboid movement the white blood cells are able to surround bacteria and ingest and destroy them. Often the white cells are themselves destroyed and the dead ones may be removed by other cells. When killed in large numbers the white cells form a large part of the solid or semi- solid matter called pus that is found in an abscess. Transmission of hormones. The glands of internal secretion, commonly called ductless glands, produce substances termed internal secretions or hormones which play a most important part in body functions. Because these glands have no ducts their secretions are absorbed into the blood through the walls of the capillaries present in the sub- stance of the glands and are then carried by the blood to the parts of the body where their action or effect is to be produced. As a rule the ductless glands are not located near the organs with which they are functionally associated and consequently the hormones may be car- ried considerable distances in order to produce their effects. Some hormones which have a more or less general systemic action are continually carried to all parts of the body. By this distribution of hormones the blood serves as a means of providing the coordinated function and harmonious working of the body so necessary to its well-being. ANATOMY AND PHYSIOLOGY 33 Blood coagulation. One of the most striking properties of blood is its power to coagulate or clot. Undisturbed blood circulates in the blood vascular system of the healthy body without showing any tendency to clot, but on escaping from the blood vessels it normally begins to clot immediately. Clotting is the body’s method of pre- venting excessive loss of blood in the unavoidable injuries met with in ordinary life. In the process of clotting both physical and chemical factors are involved. When blood escapes from blood vessels it leaves its natural environment and its normal physical state is changed by exposure to changes in temperature, by changes in its gas and acid-base balances, and by contact with objects foreign to its natural surroundings such as air and the skin. The chemical factors are those having to do with the formation of the clot. The blood which forms a clot is at first perfectly fluid but soon becomes viscous and then “sets” into a soft jelly which quickly becomes firm enough to act as a plug. The clot becomes more compact and gradually shrinks in volume, at the same time squeezing out blood serum. The essential part of the clot is an insoluble protein substance called fibrin which is not present in normal blood but is produced from substances in the blood plasma, blood cells, and tissues when formation of a clot is necessary. Among the protein constituents of the blood plasma was named fibrinogen which is the essential chemical factor in the formation of fibrin. Fibrinogen is a protein of the globulin type probably produced in the liver, and by itself is inert or inactive. In the generally accepted theory of clotting, when fibrinogen comes in contact with thrombin, a so-called fibrin ferment formed from pro- thrombin (or thrombogen) by the action of calcium salts, they interact and fibrin formation occurs. For prothrombin to be converted into thrombin by the action of calcium salts a third substance known as cephalin (or throm- bokinase) must be present. This substance, called a thromboplastic agent, neutralizes the substance heparin which ordinarily prevents the activation of prothrombin, and is released from the injured tissues and from blood platelets which quickly disintegrate when exposed to air. As fibrin is formed fine threads, fibrils, or needles of it traverse the escaping blood in various directions and encircle groups of blood cells. The meshes of this fibrin network draw closer together, the cells are packed more tightly together, blood serum is squeezed out, and a clot or coagulum is formed. The process of clotting may be expressed diagrammatically as follows: Cephalin >Prothrombin + Calcium salts = Thrombin | Thrombin + Fibrinogen = Fibrin Heparin The formation of a clot closes the opening of wounded blood vessels and prevents great loss of blood. A clot also closes the opening in a wound and is the basis for the growth of new tissue in the process of healing. The clotting power differs in different individuals and normally 3 to 5 minutes is sufficient time for a clot to form, but in rare cases even trivial wounds may cause severe and dangerous bleeding. The condition in which clotting of the blood is delayed is known as hcemophilia and a person having this condition is known as a hcemophiliac. The formed elements of the blood. Red blood cells, or erythrocytes, are circular, biconcave discs or bodies with- out a nucleus that give to the blood its characteristic color (fig. 23). They are about %200 of an inch in diameter and in the adult male number about 5,000,000 34 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Figure 23.—Types of blood cells ; a and 6, red blood cells ; c, polymorphonuclear basophile ; d, polymorphonuclear eosinophile; e and f, small lympho- cytes ; g, large lymphocyte; h, neutrophilic myelocyte; i, primitive type of myelocyte; j and k, monocytes; I, polymorphonuclear neutrophile; m, clump of normal platelets. (Stitt, Clough, and Clough, modified.) ANATOMY AND PHYSIOLOGY 35 per cubic millimeter of blood. Their red color is due to the presence in them of hemoglobin, a substance composed of an iron salt and a protein and which has the power of combining easily with oxygen to form oxyhemoglobin, a loose chemical combination of oxygen and haemoglobin by which oxygen is carried from the lungs to the body tissues. Haemoglobin also possesses the power of readily combining with carbon dioxide and carries it from the tissues to the lungs. The affinity of oxygen and carbon dioxide for haemoglobin depends upon the concentration of these gases at the point of exchange. In the lungs, oxygen being at a greater concentration than carbon dioxide, the haemoglobin exchanges its carbon dioxide for oxygen and forms oxyhaemoglobin, but in the body tissues carbon dioxide is at a greater concentration than oxygen and the haemoglobin exchanges its oxygen for carbon dioxide forming carb-hemoglobin. In the adult, red blood cells are reproduced in the red marrow of bone. The cells there produced have a nucleus which they lose before entering the blood stream. A large number of red blood cells are destroyed daily, in what manner it is not definitely known. It may take place in the liver, the spleen, or in the lymph nodes, and it is probable that many are broken to pieces by the buffetings they receive in the circulation. It is known, however, that a certain amount of hsematin, a decomposition product of haemoglobin, is excreted in the bile, a fact which apparently substantiates the belief that some red blood cells are destroyed in the liver. Red blood cells depend upon the percentage of salt or sodium chloride present in the blood plasma for the maintenance of their form. Normally the amount of salt is equivalent to about a nine-tenths of 1 per cent solution of sodium chloride which fluid is isotonic or has the same osmotic pressure as the tissue fluids. If the percentage of salt is less the red cells will absorb water, swell, and burst, and their haemoglobin is discharged. This is called hemolysis and it may be caused by certain bacterial products called hemolysins. If the percentage of salt is above the normal, water is extracted from the red cells and they shrivel or become crenated. These facts must be remembered in intravenous medications. In the human being the color of the blood in the arteries is bright red, because the haemoglobin in it is combined with oxygen, or is oxygenated; in the veins the color of the blood is dark red because the haemoglobin has given off its oxygen and exchanged it for carbon dioxide. White blood cells, or leucocytes, are nucleated blood cells and vary in size and shape (fig. 23). They are, in fact, almost colorless, are somewhat larger than red cells, and number about six to eight thousand per cubic millimeter of blood under normal conditions. This number may increase for various reasons and such an increase is called leucocytosis. Certain pathological con- ditions such as acute infections, malignant growths, poisonings, etc., usually cause an increase in the number of white cells. When the number of white cells drops below the normal standard the condition is known as leucopenia and is found in certain uncomplicated infections, poisonings, debilitations, etc. The principal function of the white cells is to combat disease. This they do by contributing to the formation of antibodies and by ingesting and destroy- ing bacteria, a process called phagocytosis. They also aid in the absorption of digested fat and proteins, and in the clotting of blood. Leucocytes have the striking property of amoeboid movement which enables them to alter their shape, ingest and destroy bacteria, and to move themselves and pass through the walls of blood vessels into the surrounding tissues. This passing into tissues is known as migration and is one of the phenomena of inflammation. 36 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY White blood cells are divided into three distinct groups known as granulo- cytes, lymphocytes, and monocytes, which differ from one another in origin, structure, and function. There are three varieties of granulocytes called neutrophilcs, eosinophiles, and hasophiles, all of which are polymorphonuclear (having more than one irregularly shaped nucleus). Lymphocytes are known as large and small. When stained for microscopical examination and differential counting, white blood cells show many variations of color in the nucleus and cytoplasm, and it is by these variations that the different kinds of white cells are recog- nized. When a differential count made in acute infections shows an increase in the percentage of immature white cells it is considered roughly proportional to the severity of the infection. Such an increase of immature white cells is due to the fact that infections promptly cause a demand for additional white cells to combat the infecting organism and as the reserve supply of mature or fully formed white cells is relatively small the demand for the increase is met by the production of new cells, many of which enter the circulation before their development is completed. Blood platelets, or thrombocytes, are round or oval bodies in the blood that consist only of cytoplasm (fig. 23). They vary greatly in size and shape, have no nucleus, are smaller than red blood cells, and number from 300,000 to 800,000 per cubic millimeter of blood, according to the method used to count them. They are an essential element in blood coagulation or clotting, mixing with fibrin to form a firm clot, and are be- lieved to be fragments of the cytoplasm of multinuclear giant cells of the bone marrow (megakaryocytes) that have been pinched or broken off. The blood-vascular system. The organs of the blood vascular system are the heart, the arteries, the capillaries, and the veins. These form a closed system of tubes called vessels through which the blood circulates and reaches all parts of the body, and a muscular pump which propels the blood through the vessels. The heart is a hollow, muscular organ located in the front and center of the thoracic cavity of the chest, between the lungs, with a large part of it lying directly back of the sternum or breast bone. It is about the size of a closed fist and closely resembles a strawberry in shape. The base of the heart points upward, backward, and to the right, and the pointed end, or apex, points downward, forward, and to the left (fig. 24). The heart is enclosed in an inverted sac of fibro-serous membrane called the pericardium, the inner layer of which adheres closely to the musculature of the heart. The outer surface of the pericardium turns back over the inner layer and forms a cavity which contains a small quantity of fluid known as the pericardial fluid that lubricates the surfaces of the pericardium and prevents Figure 24.—The heart. (Mason.) ANATOMY AND PHYSIOLOGY 37 friction during the movements of the heart. The inside of the heart is lined with a delicate serous membrane called the endocardium. The main portion of the heart is composed of muscular tissue called the myo- cardium. This muscular tissue is of a type found only in the heart, being striated or striped, but involuntary. Some of the muscles of the heart run transversely, others longitudinally, others obliquely, while those in the apex make a spiral turn or twist. This intricate arrangement makes possible an even and complete closing of the heart cavities during contraction. The interior of the heart is completely separated into right and left halves by a longitudinal muscular septum, and each half is divided into an upper, re- ceiving chamber, the auricle, and a lower, ejecting chamber, the ventricle. Consequently, there are four cavities in the heart. Each auricle communicates with its corresponding ventricle by means of an oval aperture called the auri- cula-ventricular opening or valve. During foetal life there is an open- ing between the auricles of the heart known as the foramen ovale, which, however, closes immediately after birth. The walls of the auricles are much thinner than those of the ventricles and the wail of the left ventricle is much thicker than that of the right ventricle. This difference in development is because the ventricles perform a greater amount of work than the auricles and the left ventricle performs more work than the right. Each of the four cavities of the heart is lined with endocardium which, by folding back upon itself, forms the valves of the heart. These valves allow the free passage of blood in the proper direction but effectually prevent its re- turn. The valves differ in the number and shape of the cusps or segments of which they are made and are named according to the number and shape of the cusps, or the openings which they guard. The right cmriculo-ventricxdar valve is also known as the tricuspid valve from the fact that it has three triangular-shaped cusps; the left auricula-ventricular valve is also known as the bicuspid or mitral valve from its two triangular-shaped cusps. Both the pulmonary valve and the aortic valve, opening respectively into the pulmonary artery and the aorta, have three half-moon-shaped cusps because of which they are known as semilunar valves. The heart is nourished by blood supplied to it through the right and left coronary arteries and its nerve supply is from the pneumogastric nerve and the sympathetic nervous system. The central nervous system can control and regulate the rhythmical, automatic contractions of the heart which are con- tinuous during life but it has nothing to do with the cause of those contractions, whose origin is not definitely known. The heart action consists of wave-like contractions, beginning in the auricles and passing to the ventricles, followed by dilatations. These contractions and dilatations are alternate and continuous and occur normally at the rate of about 72 per minute, although this rate varies according to age, sex, exercise, temperature, and in some pathological conditions. Contraction, or systole, as it is called, is a period of work; dilatation, or diastole, is a period of rest or relaxation. The time from the appearance of any feature of heart action to the appear- ance of that feature again is known as a complete cardiac cycle, during which blood is received into and ejected from the heart cavities. The events occur- ring in the heart during a single cardiac cycle and which show how the heart acts are here summarized. Ejection of blood from the ventricles having been completed, the ventricles quickly relax from the contraction which ejected the blood and the semilunar valves in the ventricles close. The’ auriculo-ven- tricular valves have been closed since the last filling of the ventricles with 38 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY blood and the auricles are now being steadily filled with blood from the large veins entering them while the ventricles are relaxed or resting. During this period of relaxation all the valves in the ventricles are closed and the ventri- cles are completely shut off on both sides for a short time. By the time the relaxation of the ventricles is complete the pressure of blood in the auricles has caused the auriculo-ver tricular valves to open and from then until the beginning of the brief auricular contraction blood from the large veins entering the auricles is flowing into and filling both the auricles and the ventricles. Soon the ventricles become more tense as the quantity of blood in them in- creases, the auriculo-ventricular valves float into position for closing, and the auricular contraction begins. At the end of the brief contraction of the auricles a sudden wave of blood is sent into the ventricles, completely filling them, the auriculo-ventricular valves close, and contraction of the ventricles begins, with the ventricles again being shut off momentarily due to all their valves being closed. The increasing pressure of the blood from the ventricular contraction causes the semilunar valves to open and blood is forced into the large arteries opening from the ventricles as long as the contraction lasts. The action of a normal heart produces two distinct sounds which may be heard by applying the ear to the chest. One is a long, booming sound caused when the auriculo-ventricular valves close and the ventricles contract; the other is a short, sharp sound, attributed to the closing of the semilunar valves. Arteries are hollow, elastic tubes that carry blood away from the heart. They have a certain amount of rigidity and consist of three layers, an inner lining of vascular endothelium, a middle muscular layer composed of involun- tary muscle tissue and elastic fibrous tissue, and an outer fibrous-tissue coat. Arteries have a nerve supply from the sympathetic nervous system by which the size of the passage-way in the arteries may be dilated or constricted. The smaller divisions of arteries are called arterioles. Capillaries are minute, hair-sized vessels through which the blood passes from the arteries to the veins. They have very thin walls of endothelium only, communicate with each other, and form a dense, interlacing network in all parts of the body. In passing through the capillaries the blood gives its nutritive materials to the tissues and takes from the tissues the various waste products that are to be carried away, the exchange taking place through the very thin walls of the capillaries. Veins are hollow collapsible tubes that carry blood to the heart. Their structure is similar to that of the arteries but their walls are much thinner, the middle layer containing less muscular tissue and elastic fibrous tissue. In many of the veins there are semilunar valves in pairs which act to prevent the backward flow of blood. They begin as minute venules formed from capillaries which have joined together. In tracing the circulation of the blood (Fig. 25) it is necessary to begin at and return to a given point. In this case the given point will be the right auricle where venous, or impure, blood is entering from the inferior and superior venae cavce. This venous blood passes from the right auricle through the right auriculo-ventricular opening past the tricuspid valve, into the right ventricle. When the right ventricle contracts the tricuspid valve closes and the blood is forced past the pulmonary semilunar valve into the pulmonary artery. This artery divides into two branches, one going to each lung where it subdivides into smaller arteries, arterioles, and capillaries which surround the alveoli, or air sacs, of the lungs. During its circulation in the lungs the blood becomes aerated and is returned through small vessels to the four pulmonary veins, two from each lung, which empty into the left auricle. From ANATOMY AND PHYSIOLOGY 39 the left auricle the blood passes through the left auriculo-ventrieular opening past the bicuspid or mitral valve into the left ventricle where, upon contrac- tion of this part, it is discharged past the aortic semilunar valves into the aorta. From the aorta the blood flows through its branches, the arteries, and the arterioles, to the capillaries in every part of the body. The blood is returned by the capillaries to the veins and finally reaches the right auricle through the veme cavse. The contraction of the left ventricle, forcing the blood into the arteries, causes a wavelike ex- pansions of the arteries which is synchronous with a heart beat. This is called the pulse, and may be felt at certain points where the arteries approach the body sur- face. The most common location is where the radial artery passes over the distal end of the radius, in each of the upper extremities. Blood pressure is the force of the blood ex- erted against the walls of the vessels in which it is contained. Although the term includes the pressure in the arteries, veins, and capillaries, the usual application of the term is to arterial pressure alone. The highest pressure—that is, that pro- duced by the forceful propulsion of the blood through the arteries at each con- traction of the ventricle—is known as the systolic blood pressure. Under normal conditions in the young adult this pressure is equivalent to about 120 millime- ters of mercury, but varies as to age, sex, and condition of arteries and heart. Roughly, systolic blood pressure equals 100 plus the age of the individual. A certain amount of blood pressure is maintained in the arteries during the period of cardiac relaxation. This is caused by the elasticity and tonicity of the arteries and by the peripheral resistance. This pressure is known as the diastolic blood pressure. In normal young adults it is equivalent to from 70 to 90 millimeters of mercury. The difference between these pressures is called the pulse pressure. The blood vessels. The system of arteries and arterioles may be compared to a tree with the trunk giving off main branches which divide and subdivide again and again Figure 25.—Schema of circulation of the blood. (American Red Cross, modified.) 40 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY until they are but minute twigs. The arteries are constantly carrying a pulsat- ing stream of blood which leaves the arterial tree at the finest subdivision and passes into the network of capillaries. In many locations in the body arteries that arise from different sources join together to form a union called anas- tomosis, a good example of which can be found in the palm of the hand. In case some important artery is injured these anastomoses provide a collateral circulation that furnishes the necessary blood supply. The main trunk of the arterial tree is the aorta with which the discussion of the arteries will begin. The aorta arises from the left ventricle of the heart, ascends a short distance, arches backward above the root of the left lung, and descends along the spinal column through the diaphragm to terminate at the level of the fourth lumbar vertebra by dividing into the right and left common iliac arteries. During its entire course the aorta is a continuous single trunk which gradually dimin- ishes in size and gives off branches at various points. The portion of the aorta which is situated in the thorax is commonly called the thoracic aorta and con- sists of the ascending, the arch, and part of the descending aorta; the remain- ing portion is called the abdominal aorta. The ascending aorta, a short part 2 to 21/4 inches long and contained within the pericardium, gives off two branches, the right and the left coronary arteries which supply the heart itself with nourishment. The arch of the aorta extends from the ascending aorta, above the root of the left lung, to the border of the fourth thoracic vertebra. During its course it gives off three branches, the innominate, the left common carotid, and the left subclavian arteries. The innominate artery is a short arterial trunk 1% to 2 inches in length arising from the right upper surface of the arch of the aorta and ascending obliquely toward the right sterno-clavicular articulation where it divides into the right subclavian and the right common carotid arteries. The left common carotid artery arises at the middle of the upper surface of the aortic arch and the right common carotid artery is one of the termi- nal branches of the innominate artery. The common carotid arteries ascend obliquely on each side of the neck to the level of the laryngeal prominence where they divide into the external and the internal carotid arteries. The external carotid arteries supply the throat, tongue, face, ears, and the walls of the cranium; the internal carotid arteries supply the brain and the eyes. The subclavian arteries, the right a terminal branch of the innominate artery and the left springing directly from the aortic arch, form the first part of the arterial trunks supplying the upper extremities. They give off branches to the back, the chest, the neck, and the brain, the principal one being the vertebral which runs upward through the transverse processes of the cervical vertebrse to the brain. Both pass upward and outward under the clavicle and over the first rib, at the outer border of which they continue as the axillary arteries. These vessels give off branches to the chest, the shoulder, and the arm. The axillary artery on passing the armpit becomes the brachial artery, which gives off branches to the bone and muscles of the arm, and terminates just below the level of the elbow by dividing into the ulnar and the radial arteries. The ulnar artery, the larger of the two branches of the brachial artery, extends along the medial side of the forearm to the palm of the hand where it forms the superficial volar arch. The radial artery extends along the outer side of the forearm to the palm of the hand where it forms the deep volar arch. The deep volar arch anastomoses with the superficial volar arch and supplies the hand with blood. ANATOMY AND PHYSIOLOGY 41 The descending aorta is from 7 to 8 inches long and extends from the arch of the aorta to the diaphragm. It gives off the following branches: 1. The intercostal arteries which are paired, 9 and 10 on each side, and supply the intercostal muscles and the adjacent structures. 2. The superior phrenic arteries, which are small branches supplying the upper surface of the diaphragm. 3. The bronchial arteries, two left and one right, which are the nutrient ves- sels of the lungs and the bronchi. 4. The mediastinal arteries which are numerous small branches supplying the lymph nodes and the areolar tissue of the mediastinum. 5. The oesophageal arteries, four or five in number, which anastomose around the oesophagus. 6. The pericardial arteries, three or four small vessels distributed to the pericardium. The abdominal .aorta begins at the aortic opening of the diaphragm at the lower level of the last thoracic vertebra, and terminates at the level of the fourth lumbar vertebra by dividing into the common iliac arteries. The branches of the abdominal aorta are divided into two groups, those which supply the viscera, the visceral arteries, and those which are distributed to the walls of the abdomen, the parietal arteries. The visceral group consists of: 1. The coeliac artery, a short wide vessel, one-half inch in length which arises from the front of the aorta just below the diaphragm and divides into three branches; the gastric, supplying the stomach; the hepatic, supplying the liver, the gall bladder, and the duodenum; and the splenic, supplying the spleen and a part of the stomach and the pancreas. 2. The suprarenal arteries, right and left, which are distributed to the suprarenal glands. 3. The renal arteries, right and left, two large trunks arising from the sides of the aorta which supply the kidneys. 4. The superior mesenteric artery which arises from the front of the aorta just below the suprarenal arteries and supplies the small intestine, except the duode- num, and half of the large intestine. 5. The spermatic arteries (ovarian in female), right and left, which are dis- tributed to the testes (ovaries in the female). 6. The inferior mesenteric artery which arises from the front of the aorta about an inch above its division and is distributed over the lower half of the large intestine and the rectum. The parietal group includes: 1. The inferior phrenic arteries, right and left, which supply the lower sur- face of the diaphragm. 2. The lumbar arteries, usually four pairs, which supply the posterior and lateral abdominal wall and muscles. 3. The middle sacral artery, a small vessel which is a direct continuation ol the abdominal aorta and supplies the sacrum and coccyx. The common iliac arteries (left and right) begin at the division of the aorta, extend downward and outward for 2 inches, when they divide into the hypogastric and the external iliac arteries. The hypogastric arteries supply branches to the pelvic walls, the pelvic viscera, the external genitals, and the biittocks. The external iliac artery forms the first part of a continuous arterial trunk which supplies the lower extremity and extends to the lower border of the inguinal ligament, where it passes from the abdomen through the femoral opening and becomes the femoral artery. The external iliac artery partially supplies the anterior abdominal wall and the external genitals. The 42 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY MAOOeM.39 Figure 26.—Schema of principal arteries and veins. (U. S. Naval Medical School.) * ANATOMY AND PHYSIOLOGY 43 femoral artery runs an oblique course along the femur inward and back- ward in the upper three fourths of the thigh to the posterior surface of the knee joint, where it becomes the popliteal artery. The femoral artery supplies branches to the muscles, the bone, and the skin of the thigh. The popliteal artery, after giving off branches anastomosing around the knee joint, divides into the anterior and the posterior tibial arteries. The anterior tibial artery, the smaller of the two branches, passes forward between the tibia and fibula, and then down the front of the leg to the ankle, where it becomes the dorsalis pedis artery which supplies the dorsal surface of the foot. The posterior tibial artery passes down the back of the leg to the ankle, where it divides into two branches which supply the sole of the foot. It gives off various branches, the largest of which, the peroneal artery, also passes to the plantar surface of the foot and supplies some of the muscles and skin of the foot and the ankle joint. The veins begin as small branches called venules which unite to form larger vessels. Veins differ from arteries in that they have a larger capacity, thinner walls, and contain valves which assist in supporting the column of blood. This is necessary because most of the cardiac impulse is lost during the course of blood through the capillaries. The veins are divided into the pulmonary, the systemic, and the portal systems. It has been shown that the pulmonary arteries end in capillaries in the walls of the alveoli of the lungs. After oxygenation, blood is collected from these capillaries by the venules which unite to form a vein from each of the five lobes of the lungs. The right lung, however, sends but two veins to the heart as does the left lung, for the veins of the superior and the median lobes of the right lung unite. There are, then, four pulmonary veins carrying blood from the root of the lungs to the left auricle of the heart. These are the only veins in the body which carry arterial, or oxygenated blood. The veins of the systemic circulation are arranged in two sets, the deep and the superficial. The deep veins as a rule accompany their corresponding arteries and usually are called by like names. The larger arteries have only one accompanying vein but the medium sized or smaller arteries usually have two accompanying veins which anastamose freely with each other. The super- ficial veins lie just under the skin where in many localities they may be easily seen, and end by entering the deeper tissues to join the deep veins. The superficial veins of the head which drain the venous blood from the scalp and face and from the cancellous tissue of the skull empty into the right and left external jugular veins. The anterior jugular vein of the neck usually empties into the external jugular veins and with them drains the neck. The external jugular veins empty into the subclavian veins. Yenous blood from the brain and the interior of the skull drains into venous channels situated between two layers of the dura mater of the brain and having the same lining as the veins which empty into them. These channels are also known as venous sinuses and the most important ones are the superior saggital sinus running from front to back across the top of the brain, the two transverse or lateral sinuses, one on each side of the brain, and the two cavernous sinuses, one on each side of the sphenoid bone. The cavernous sinuses communicate with the veins of the face through the veins of the orbits and are therefore especially receptive to the backward spread of infective organisms from the nose and cheeks with resultant clotting of blood in the sinuses and almost cer- tain death. The saggital and cavernous sinuses empty into the transverse sinuses and they empty into the internal jugular veins, one on each side of the 154294°—39 4 44 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY neck, which, with their tributaries, also drain the deep portions of the neck, the tongue, the jjharynx, and the thyroid gland. The superficial veins of the upper extremity start from the dorsal venous arch and the volar venous plexus of the hand and consist of the cephalic, basilic, median, and tributary veins. The cephalic vein passes up the outer side of the forearm and arm in front of the elbow and empties into the upper part of the axillary vein just below the clavicle. Below the elbow it gives off the median cubital or median basilic vein which passes across and joins the basilic vein. The basilic vein passes up the inner side and back of the forearm, receives the median cubital vein below the elbow, then passes upward in the arm and in the axilla joins the brachial veins to form the axillary vein. The median vein passes up the forearm to the level of the elbow where it joins the basilic vein. The deep veins of the upper extremity begin from smaller veins in the hand as the radial veins and the ulnar veins and as they pass upward receive tribu- tary veins. In front of the elbow they unite to form the brachial veins which continue upward through the arm and in the axilla unite with the basilic vein to form the axillary vein. The axillary vein passes on across the axilla and at the outer border of the first rib becomes the subclavian vein which continues on to the sternal end of the clavicle and there unites with the internal jugular vein to form the innominate vein. At this point the right subclavian vein receives the lymphatic duct and the left receives the thoracic duct. Before uniting with the internal jugular vein the subclavian vein receives the external jugular vein and sometimes the anterior jugular vein. The innominate veins, one on each side, receive numerous tributary veins draining various parts of the thorax and pass obliquely downward toward the sternum and unite to form the superior vena cava which receives the azygos vein draining most of the intercostal spaces and several small tributary veins. The superior vena cava, which returns to the heart all venous blood from the body above the diaphragm, descends on the right side of the center of the thorax, with a slight convexity to the right, and ends in the upper part of the right auricle of the heart. The blood which has supplied the heart itself with nourishment is returned as venous blood by a venous channel called the coronary sinus which lies in a groove on the back of the heart and enters the right auricle near the junction of the inferior vena cava with the right auricle. Tributary veins, most of which empty into the coronary sinus, collect the venous blood from the heart. The superficial veins of the lower extremity are the internal, great, or long saphenous vein which starts on top of the inner side of the foot and runs up the inner side of the leg and thigh to terminate just below the groin in the femoral vein, and the external, small, or short saphenous vein which starts in a similar manner on the outer side of the foot and terminates just behind the knee in the popliteal vein. Both saphenous veins are joined by numerous tribu- tary veins. The principal deep veins of the lower extremity are the anterior and posterior tibial veins, the peroneal veins, the popliteal vein, the femoral vein, and the deep femoral vein. The anterior and posterior tibial veins start from smaller veins in the foot, run upward and unite behind the knee to form the popliteal, the posterior tibial veins in the passage upward being joined by the peroneal veins which accompany the peroneal artery. The popliteal vein extends upward through the lower third of the thigh where it becomes the femoral vein, being joined shortly after its origin by the small saphenous vein. The femoral vein extends upward through the upper two-thirds of the thigh and then becomes the external iliac vein, being joined just before its termina- ANATOMY AND PHYSIOLOGY 45 tion by the great saphenous vein. The deep femoral vein communicates with the popliteal vein below and the inferior gluteal vein above. Only the principal veins of the abdomen and pelvis will be named, beginning with the external iliac vein which runs along the brim of the pelvis to the sacro- iliac joint where it unites with the hypogastric or internal iliac vein, which drains the pelvis, to form the common iliac vein. The common iliac veins, one from each side of the body, pass obliquely upward and unite on the right side of the fifth lumbar vertebra to form the inferior vena cava, into which the lumbar veins, the renal veins with the left suprarenal and left spermatic or ovarian veins, the right suprarenal and right spermatic or ovarian veins, and the hepatic veins empty. The inferior vena cava, which returns to the heart all venous blood from the body below the diaphragm, ascends along the spinal column on the right of the aorta, passes through the diaphragm into the thoracic cavity and ends in the lower part of the right auricle of the heart. The portal system of veins consists of the veins which drain blood from the stomach, the intestines (with the exception of the lower part of the rectum), the spleen, the pancreas, and the gall-bladder. Among the veins collecting blood from these viscera are the splenic and the superior mesenteric veins which unite behind the neck of the pancreas to form the portal vein, the prin- cipal one in the system as all the others ultimately empty into it. The veins communicating with the portal vein all have numerous tributary veins. The portal vein runs upward and slightly to the right to the transverse fissure of the liver where it divides into two branches which enter the right and left lobes of the liver respectively. After entering the liver the branches of the portal vein continue to branch until they end in small capillaries in blood spaces in the liver substance where the hepatic veins begin and, after leaving the liver, continue on to enter the inferior vena cava, as mentioned before. The purpose of the portal circulation is to subject the blood containing the end products of digestion to the special action of the liver prior to entering the general circulation. THE LYMPH AND THE LYMPH-VASCULAR SYSTEM Lymph is a colorless fluid, rich in white blood cells, of essentially the same composition as blood plasma, and largely the product of the filtration of blood plasma through the walls of the blood capillaries. It is found in the lymph vessels and in all of the tissue spaces of the body and serves as a medium for carrying nourishment and oxygen to the tissues and waste products from them. The tissues and organs of the body are bathed in lymph which then acts as a lubricant in aiding movement. After a meal, the lymph coming from the small intestine has a milky appearance because of the presence of fat in it and it is then called chyle. The lymph-vascular system. Lymph vessels and lymph glands constitute the lymph-vascular system which forms a network throughout the body and connects with serous and tissue spaces. There are also certain lymph trunks in the system the most important of which is known as the thoracic duct. The flow of lymph in the system is always from the tissues toward the terminal lymph vessels and is maintained in this direction mainly by the difference in pressure at the two ends of the system. The pressure is lowest at the terminal end and the termi- nal lymph vessels are the thoracic duct and the right lymphatic duct which empty into the left and right subclavian veins, respectively. 46 HANDBOOK OF THE HOSPITAL CORPS, XJ. S. NAVY The lymph vessels. In many respects the lymph vessels resemble veins and have been found in every part of the body which possesses blood vessels except the brain, spinal cord, eyeball, and internal ear. Like the veins many of the lymph vessels contain valves which prevent the backward flow of the lymph, but, unlike the veins, they communicate directly or indirectly with the great serous cavities of the body and their continuity is interrupted by interposed lymph glands. Lymph vessels find their beginning in the tissues and organs of the body where they are known as lymphatic capillaries and which unite to form larger vessels. As the lymph vessels attain a larger size their walls become stronger due to the presence of elastic tissue and the larger vessels are composed of three layers as are blood vessels. Lymph vessels are known as superficial lymph vessels and deep lymph vessels, according to their position in the body. The super- ficial vessels collect lymph from the skin and subcutaneous tissue; the deep from all other parts of the body. The thoracic duct is about the size of a goose quill and is from 15 to 18 inches long. It extends from the level of the second lumbar vertebra to the root of the neck where it empties into the left subclavian vein at its junction with the left internal jugular vein. This lymph vessel lies just in front of the spinal column and receives the lymph from all lymphatic vessels of the body except those from the right side of the head, the right upper extremity, the right chest and its contents, the right side of the diaphragm, and the upper surface of the liver, all of which finally empty into the right lymphatic duct. The right lymphatic duct, which is not always present in the body as a dis- tinct lymph trunk, is about % to % inch long, lies at the right side of the root of the neck, and empties into the right subclavian vein at its junction with the right internal jugular vein. The lymph glands. These are small bean-shaped bodies that occur in groups of from 2 to 15 along the courses of the lymph vessels except for a few in the subcutaneous tissue that are single. These groups of lymph glands are known as lymph nodes. The glands vary considerably in size, are composed of lymphoid tissue, and act partly as filters for the removal of minute infective organisms and particles from the lymph stream. They also are the source of origin of most of the white blood cells known as lymphocytes. THE RESPIRATORY SYSTEM AND RESPIRATION Respiration, or breathing, in some form is a characteristic of all living organisms and without it life cannot continue. It may be defined as the process of gaseous exchange between a living organism and the medium in which it lives. The medium in which the animals and plants of Earth live is air, the mixture of gases which surrounds the earth. One of the gases in air is oxygen which both animals and plants require for their vital processes, those functions of the body on which life is directly dependent. These vital processes, for which the term metabolism is used, are the chemical changes proceeding continually in living cells by which the energy to maintain the processes and activities necessary for life is provided. In the production of this energy, destruction or waste occurs and one of the waste products is the gas called carbon dioxide which is exchanged for oxygen in the process of respiration. In the single-celled animals and plants the exchange takes place directly between the organism and its surrounding medium but in the more complex animals some form of respiratory apparatus is necessary. Man and the air-breathing ANATOMY AND PHYSIOLOGY' 47 vertebrates are provided with lungs or gills where the waste product carbon dioxide is exchanged for oxygen present in the surrounding medium of air. The respiratory apparatus. In man the respiratory apparatus consists essentially of the lungs and the air passages leading into them (fig. 27), the nasal chambers, the mouth, the pharynx, the larynx, the trachea, and the bronchi. The thorax, the ribs, and the diaphragm and other respira- tory muscles taking part in respiratory movements may be considered as accessory respir- atory apparatus. The nasal chambers are the normal entrance for air to the respiratory tract. They are irregular, wedge-shaped cavi- ties having a vestibule, a re- spiratory region and an olfac- tory region and are covered with a highly vascular mucous membrane which in the respir- atory region serves to warm and moisten the inspired air. In the respiratory region there are many fine hairs called cilia which act as filters and remove dust particles from the air being inhaled. The nasal septum separates the two chambers, both of which open posteriorly into the pharynx. The mouth, strictly speak- ing, is a part of the alimentary canal or digestive tube, but because the back of it connects with the pharynx and respiration can therefore be carried on through it when it is open, the mouth is sometimes considered as a part of the respiratory apparatus. The pharynx, like the mouth, is really a part of the alimentary canal, of which it is the expanded upper part. In the respiratory system it serves merely as a passageway for the air as it connects above with the nasal cham- bers and below with the larynx. The larynx, or organ of voice, lies in the upper and front part of the neck between the trachea and the hyoid bone and tongue. Above it opens into the pharynx, below it becomes continuous with the trachea. It is a triangular, box-like structure made up of several cartilages connected together at certain points by ligaments and membranes, and the upper part of the largest of these cartilages, the thyroid cartilage, forms a marked prominence in the midline of the neck which is the so-called “Adam’s apple.” In the upper part of the larynx there is a space commonly called the glottis. Along the sides of this space, extending from front to back and projecting into it are two pairs of elevated folds of mucous membrane. The folds in the upper pair are called the false vocal cords; those of the lower, more definite pair are the true vocal cords, the chief agents in the production of voice. Extending upward and Figure 27.—The larynx, trachea, right and left bronchi, and the lungs. The latter have been cut open to show the method of division and subdivi- sion of the bronchi. (Mason.) 48 HANDBOOK OF THE HOSPITAL CORPS, IJ. S. NAVY backward over the upper opening of the larynx is a thin leaf-like flap of fibrous-cartilage called the epiglottis which in the act of swallowing directs the material being swallowed into the opening of the oesophagus. The trachea, or windpipe, is a wide fibro-muscular tube which extends down- ward from the larynx about 4 to 4% inches and there divides into the right and left bronchi. It lies in front of the oesophagus and its walls consist of fibro-elastic membrane and muscular tissue with a lining of mucous membrane. Because of the elasticity of its walls the trachea has considerable mobility but to prevent dragging on the roots of the lungs during movements of the head and neck the lower end is fixed in its position. Embedded in the fibro-elastic membrane of the trachea is a series of from 15 to 20 C-shaped cartilaginous bars which strengthen the tube and keep it always open. These bars are complete in front but incomplete behind and consequently the back wall of the trachea is flattened. In the mucous membrane lining of the trachea are many cilia which help to produce an upward movement of the mucus present on the surface of the mucous membrane. The bronchi begin as the two terminal branches of the trachea and are known individually as the right and the left bronchus. They are structures similar to the trachea but have cartilaginous plaques instead of bars and each bronchus enters into the corresponding lung. There they branch and rebranch like a tree, and the smallest branches, the bronchioles, end in tiny membranous sacs called air vesicles or alveoli, which are multitudinous in number and make up the greater part of the lung substance. The alveoli have very thin walls in and about which the blood capillaries are distributed in such numbers that they form the densest plexus, or network, of capillaries to be found anywhere in the body. The right bronchus is larger, shorter, and more vertical than the left and foreign bodies in the trachea are likely to be directed toward it. The lungs, two in number, occupy practically all of the cavity of the thorax, one being located in each of the two chambers called pleural cavities into which the thoracic cavity is divided by the mediastinal septum. They are light, soft spongy organs made up of the alveoli, bronchial tubes, blood vessels, lymphatics, and nerves, held together by connective tissue. The right lung has three lobes and is larger, broader, and shorter than the left which has only two lobes. The surfaces of the lungs next to the ribs are convex so as to fit the curvature of the thorax, and the other surfaces present concave hollows to fit the various organs wdiich are in contact with the lungs. One of these hollows is the pericardial concavity which is adapted to the shape of the heart. Above the back of this hollow there is a wedge-shaped depression on each lung known as the hilum, within which the bronchus, blood vessels, nerves, and lymph vessels enter and leave. These structures are bound together by a sheath of pleura to form a pedicle or stem by -which the lung is attached to the mediastinal wall of the pleural cavity. This pedicle or stem is called the root of the lung. There are two types of circulation in the lungs, the pul- monary, which brings the blood from the right heart to the lungs for the exchange of gases called oxygenation or aeration and returns it to the left heart, and that from the bronchial branches of the aorta which supply the lung tissue itself. The nerve supply of the lungs is from the vagus nerve and the sympathetic nervous system. The pleura is a serous membrane which envelopes the lungs and lines the walls of the thoracic cavity. It is without a break in its continuity and thereby forms a closed sac within which are all the organs located in the thorax. The inner surface of the pleura has a smooth, glossy appearance and is moistened with a small amount of serous fluid. The portion of the pleura which covers ANATOMY AND PHYSIOLOGY 49 tiie lungs is known as pulmonary or visceral pleura and is very firmly bound down to the surface of the lung. It is very thin and completely covers the entire surface of the lung. At the root of the lung the pulmonary pleura turns back on itself to line the walls of the thoracic cavity and it is then known as the parietal pleura or, according to the different parts of the thoracic cavity it lines, as the costal pleura, the diaphragmatic pleura, the mediastinal pleura, and the cervical pleura. Each lung is enveloped in its own pleural sac and these sacs do not communicate with each other. The serous fluid on the pleura permits respiratory movements of the lungs with little if any friction as it acts as a lubricant. The inner surface of the pleura sometimes becomes roughened by inflammation and this condition is known as pleurisy. Should the thoracic wall be perforated, thus allowing air to enter a pleural cavity, the lung of that side will collapse. The process of respiration. As has been explained at the beginning of this section, respiration is a necessity in the life of air-breathing vertebrates and it may be said that the purpose of respiration is to supply the body with oxygen and to remove carbon dioxide. This interchange of gases, which takes place in the lungs, is known as the oxygenation or aeration of the blood, and the actual exchange occurs in the alveoli of the lungs. Oxygen and carbon dioxide readily pass through the thin membranous walls of the aveoli and of the capillaries because both have the property of being able to pass through permeable and semi-permeable mem- branes in accordance with the natural laws of diffusion of gases. The gaseous exchange or absorption of oxygen and elimination of carbon dioxide that takes place in the lungs between the blood in the capillaries in the walls of the alveoli and the air in the alveoli may be called external res- piration; the similar exchange that occurs in the systemic capillaries between the blood and the tissues of the body may be called internal or tissue respira- tion. The latter is the respiration truly vital to life. In the section concerning blood it was stated that the blood carries oxygen from the lungs to the body tissues and carbon dioxide from the tissues to the lungs. The oxygen required by the tissues for their activities is carried to them principally in chemical combination with the haemoglobin in the red blood cells, only a very small amount being carried in physical solution as oxygen is not a very soluble gas. In the compound formed by the chemical combination of haemoglobin and oxygen, called oxyluemoglobin, the haemoglobin is almost completely saturated with oxygen. The carbon dioxide produced in the tissues during their metabolic activity is removed from them in chemical combination with haemoglobin and with constituents in the plasma, and in physical solution in the plasma. Carbon dioxide is a very soluble gas and upon reaching the plasma some of it dissolves to form carbonic acid which reacts with sodium chloride in the plasma and produces sodium bicarbonate, and a small amount is retained in the plasma in simple physical solution. The remaining carbon dioxide enters into chemical combination with haemoglobin to form carb-hsemoglobin. Oxygenated blood reaches the tissues through the blood capillaries at which point the oxygen content, and consequently its pressure, is higher than in the tissues. This difference in oxygen pressure causes the oxyhaemoglobin, which under those conditions has the property of dissociation, to give off free oxygen which diffuses through the thin walls of the capillaries and the lymph into the tissue cells. The blood, having given up its oxygen to the tissues, again contains uncom- bined or reduced hemoglobin, and therefore is ready to take up carbon dioxide. 50 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Being under higher pressure in the tissues than in the blood, the carbon dioxide diffuses from the tissue cells through the lymph and the capillary walls into the blood where it is taken up as previously explained. Deoxygenated or impure blood is carried to the lungs where the oxygen pressure in the alveoli is higher and the carbon-dioxide pressure lower than in the blood. In the lungs the carbon dioxide which was changed into sodium bicarbonate changes back to carbon dioxide. On reaching the capillaries in the alveoli the lower pressure of the carbon dioxide there causes that in the blood to diffuse through the thin walls of the capillaries and of the alveoli until an equilibrium in pressure between the carbon dioxide in the blood and in the alveoli is reached. At the same time the higher pressure of oxygen in the alveoli causes it to diffuse through the walls of the alveoli and the capil- laries and enter the blood where it combines with the reduced haemoglobin and oxyhaemoglobin is again present in the blood. In the lungs the blood does not ordinarily give up all its carbon dioxide as some is required for its action in the maintenance of respiration. The chemical change attendant upon the formation of sodium bicarbonate from carbon dioxide plays an important part in maintaining the slightly alkaline reaction of the blood. The ordinarily automatic, rhythmical movements of respiration are controlled by the respiratory center in the medulla oblongata which originates the impulses causing them. These impulses pass down the spinal cord to the nerves which supply the respiratory muscles. Probably the most important of these nerves is the phrenic which supplies the diaphragm, others being the vagus, supplying the larynx, and the intercostals, supplying the muscles of the thorax and abdomen. The respiratory center may be affected by. various conditions and it follows that the respiration is also affected. An increase in the amount of carbon dioxide (which has acid properties) in the blood increases the acidity of the blood and is immediately followed by increased respiratory movements. A decrease in the amount of carbon dioxide in the blood can cause all respira- tions to cease, which condition will remain until the normal amount of carbon dioxide is again present in the blood which stimulates the respiratory center and breathing is resumed. External sensations may affect the respiratory center; for example, the splashing of cold water on the face and chest often will stimulate resumption of breathing; a sudden plunge into cold water will cause a deep, gasping respiration. Emotional disturbances affecting the higher centers of the brain may alter respiration; for example, in excitement the respirations may increase while in shock they are usually shallow and sighing; laughing, crying, speaking, or singing, may to some extent modify respiratory movements. If for any reason the respiratory center loses its blood supply failure of respiration will ultimately occur. As has been stated in the section concerning muscles, the respiratory muscles ordinarily act automatically without conscious effort of the will. Activity of those muscles produces alternate inspirations and expirations of air in and out of the lungs which, with a period of rest between movements, constitutes what is called the cycle of respiration. This cycle is divided into three phases: 1. Inspiration, or the flow of air into the lungs; 2. Expiration, or the flow of air out of the lungs; and 3. A period of rest. The cycle is completed about 14 to 18 times per minute in the normal adult while at rest. In the act of inspiration the diaphragm contracts and the ribs are elevated by the accessory muscles of respiration, thus enlarging the thoracic cavity and creating a negative pressure in the cavity. This permits the lungs to expand and causes the outside air to rush in and equalize the pressure. In ANATOMY AND PHYSIOLOGY 51 expiration the diaphragm relaxes, and the elasticity of the lungs, together with the weight and the elasticity of the chest walls, causes the chest to return to its original size, expelling a certain amount of air from the lungs. The lungs, when filled to their utmost capacity, hold about 4,500 cc of air. Practically 500 cc of air is breathed out at a normal quiet expiration. This air which is changed at each respiration is called the tidal air. The amount of air breathed out or in may be increased by forceful expiration and inspira- tion. The amount of air left in the lungs after the most forceful expiration is about 1,000 cc and is known as the residual air. Under normal conditions the reserve supply of air in the lungs is about 2,600 cc. Certain sounds are produced by the entry and exit of air from the alveoli of the lungs and the bronchi. These sounds may be variously modified in lung diseases. Certain abnormal types of breathing may be noted. Dyspnoea is labored or difficult breathing. Apnoea is a condition in which there is a temporary cessa- tion of breathing. Asphyxia is the condition produced by oxygen starvation and is caused by prolonged interference with the aeration of the blood. THE DIGESTIVE SYSTEM AND DIGESTION In order to understand the processes concerned with digestion, it is necessary to know the meaning of the various terms used in describing this process. Digestion is the process or act by which various food substances are con- verted into simpler substances which can be absorbed and assimilated. Mastication is the division of food into small particles. This is accomplished by means of the teeth. Insalivation is the mixing of food with the saliva. This takes place within the mouth. Deglutition or swallowing is the act of transferring food from the mouth to the stomach. Enzymes are complex organic substances capable of effecting, by catalytic action, the transformation of some other compound or compounds. Absorption, as applied to digestion, means the taking up of digested food products, either in solution or sus- pension, by the blood and the lymph from the alimentary tract. Peristalsis is a wave-like contraction which passes along the intestinal tract. This movement moves or propels the contents of the intestine. Defsecation is the term applied to the act of expelling fgeces from the rectum. The digestive system consists of the alimentary canal and the accessory organs (fig. 28). The alimentary canal is a continuous tube extending from the mouth to the anus, 28 to 30 feet long and varying in size. It is com- posed of the mouth, the pharynx, the (esophagus, the stomach, and the small and large intestine. The accessory organs of digestion are the teeth, the tongue, the salivary glands, the liver, the gall bladder, and the pancreas. The mouth or buccal cavity is nearly oval in shape, and is formed in front by the lips; above, by the hard palate in front and the soft palate behind; at the sides, by the cheeks; and below or at the floor, by the tongue. This cavity opens posteriorly into the pharynx from which it is partially separated by the Figdeb 28.—Diagram of the alimentary tube and its append- ages. (Testut.) 52 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY uvula, a small flap of mucous membrane hanging from the soft palate, and the anterior pillars of the fauces, two curved folds of mucous membrane running from the uvula to the sides of the base of the tongue. In the small depression between the anterior and the posterior pillars of the fauces, on either side, is a small mass of lymphoid tissue called the tonsil. The semicircular borders of the upper and lower jaw bones, the alveolar processes, contain sockets for the reception of the teeth, of which there are two sets, the deciduous, or “milk” teeth, which erupt between the ages of 6 months and 3 years and are 20 in number, and the permanent teeth, which replace the first set between the ages of 6 and 21 years. In the adult there are 32 teeth, 16 in each jaw, 4 incisors, 2 cuspids (canines), 4 bicuspids, and 6 molars. The structure of the teeth is described in the section on Emergency Dental Treatment (p. 160). The tongue is a muscular organ occupying the floor of the mouth. It is covered with mucous membrane, contains the special organs of taste, is an important organ of speech, and assists in the mixing and swallowing of food. The salivary glands, consisting of three pairs, are compound glands which dis- charge their secretion, saliva, into the mouth. The parotid glands situated in front of and below the ears, discharge their secretion by way of Stensoris ducts which enter the mouth opposite the second upper molar teeth. The submaxil- lary glands, lying under the lower jaw, and the sublingual glands, lying under the tongue, discharge their secretion by way of ducts opening into the floor of the mouth and known as Wharton’s ducts. The pharynx is the expanded upper part of the alimentary canal and lies be- hind and communicates directly with the mouth, the nasal chambers, and the larynx. By means of the Eustachian or auditory tubes it also communicates with the tympanic cavities, or the middle ears. That part of the pharynx which is above the level of the soft palate is used only for respiration, the other part is used for the passage of food. It is a fibro-muscular structure and extends from the base of the skull, above, to the level of the sixth cervical vertebra below, where it joins and is continuous with the oesophagus. It is somewhat funnel-shaped with the wide part at the top. The upper part is open in front but the lower part gradually becomes tube-like, the anterior and posterior walls finally join, and the opening reduces in size until it is only a slit except during the passage of food. The oesophagus, or gullet, is a muscular tube about 10 inches long extending from the pharynx, above, to the stomach, below. It is situated practically in the median line of the body and inclines slightly to the left. Its upper part lies directly behind the trachea and in front of the vertebral column, the re- mainder in front of the vertebral column. It passes downward through the thoracic cavity and pierces the diaphragm about one-half inch above its termi- nation at the cardiac orifice of the stomach. Its walls are composed of three layers, an inner lining of mucous membrane, a middle layer of connective tissue, and an outer coat of both voluntary and involuntary muscle tissue. In addition it is surrounded by a covering of connective tissue which permits its free movement and by which it is loosely connected to the various structures adjacent to it. The remaining parts of the digestive system are located in the abdomen which will be briefly described before continuing with the digestive system. The abdomen is that portion of the trunk lying below the diaphragm and consists of a wall made up in part of bones, muscles, tendons, etc., and of the largest cavity in the body in which are contained the stomach, liver, gall blad- der, intestine, pancreas, spleen, kidneys, bladder, some of the generative organs, blood vessels, nerves, etc. This cavity is termed the abdominal cavity but for ANATOMY AND PHYSIOLOGY 53 descriptive purposes is considered in two parts, an upper, larger part called the abdomen proper, and a lower, smaller part called the pelvis. The abdom- inal cavity in the adult male is shaped much like a barrel, with the upper end bounded by the diaphragm and somewhat wider than the lower. For convenience in describing or locating the or- gans contained in the abdominal cavity the abdomen is considered as divided into nine regions by imaginary lines drawn on its ventral surface and each region is named appropriately (tig. 29). A continuous, smooth membrane known as the peritoneum covers the wall of the abdominal cavity and the sur- faces of the organs in it. The peritoneum is a thin, glistening, serous membrane composed of a layer of fibrous tis- sue covered over on the cavity side with a layer of flattened endothelium which secretes a small quantity of serous fluid known as peritoneal fluid that lubricates the inner sur- face of the peritoneum and permits movement of the structures in the cavity with the least degree of friction. In the male the peritoneum is a completely closed sac but in the female it is indirectly open to the surface. The portion of the peritoneum lining the walls of the abdominal cavity is known as the parietal peritoneum; that which clothes the organs, or viscera, therein is known as the visceral peritoneum. Parts of the duodenum, the colon, the bladder, and the kidneys are not covered with peritoneum; the remaining principal abdominal organs are completely clothed with it. Numerous folds of the peritoneum extend between the various organs and serve to connect them with the posterior wall of the abdomen and with one another, such as the various ligaments of the liver, and the mesentery which holds the intestine in place and contains the vessels which supply it. The omentum, an apron-like structure composed of four layers of peri- toneum with enclosed fat, is pend- ant from the transverse colon and is freely movable. It is of service in walling off inflammations or infec- tions within the abdominal cavity. The stomach is a hollow, mus- cular organ situated in the ab- domen between the oesophagus, above, and the small intestine, be- low (fig. 30). In shape it is much like a gourd, its wide, upper end, which is called the fundus, lying in the hollow of the diaphragm and directed upward, backward, and to the left, and its narrow, tapering end passing down- ward, forward, and to the right. The fully distended stomach of an adult is about 10 to 11 inches long, its greatest diameter is about 4 to 4% inches, and its Figure 29.—Surface markings of thorax and abdomen. (Gray, modified.) Figure 30.—The stomach. (Cunningham modified. 54 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY average capacity is about 2 to 2y2 pints. The size and shape of the stomach depend considerably upon its contents. The stomach has two openings, one at the upper, oesophageal end called the cardiac orifice, and one at the lower, intestinal end called the pylorus or pyloric orifice. The portion of the stomach about the cardiac orifice is called the cardiac part, that about the pyloric orifice the pyloric part. The portion of the stomach which extends from the fundus to the pyloric part, called the body of the stomach, forms a rounded chamber, is capable of great distension, and contracts to a narrow, tube-like structure when the stomach is empty. Surrounding the pylorus is a circular ring of muscle called the sphincter pylori which closes and opens the stomach outlet. The upper sur- face of the stomach is concave and is known as the lesser curvature; the lower surface is convex and is known as the greater curvature. The walls of the stomach consist of four layers of tissue, a thick, inner lining of mucous mem- orane, a layer of strong connective tissue closely attached to the lining and loosely to the muscular layer, a layer of muscular tissue in which the fibers are arranged circularly, obliquely, and longitudinally in sets, and an outer coat of serous membrane which is formed of the peritoneum. When the stomach is empty the three outer coats contract and the inner coat is thrown into many folds which disappear when the stomach is distended. In the inner lining are numerous glands which secrete the gastric juice. The intestine is a musculo-membranous tube about 28 feet long beginning at the pyloric orifice of the stomach and ending at the anal orifice which opens on the surface. It consists of the small and the large intestine which together occupy a large portion of the abdominal and pelvic cavities. The small intestine is about 23 feet long and is divided into three parts, the first, the duodenum, immediately succeeds the stomach and is about 1 foot long; the second, the jejunum, is about 9 feet long; and the third, the ileum, is about 13 feet long. The duodenum lies in a horseshoe-shaped curve and is closely fixed to the pos- terior abdominal wall; the jejunum and the ileum lie in a series of irregular loops which hre quite freely movable. The small intestine is made up of four layers of tissue, an inner lining of mucous membrane, a layer of loose but strong connective tissue attached to the lining and the muscular layer, a layer of muscle tissue consisting of an inner stratum of involuntary muscle fibers arranged circularly and an outer stratum of involuntary muscle fibers arranged longitudinally, and an outer coat of serous membrane which is formed of the peritoneum. The mucous membrane lining of the small intestine lies in folds, some of which disappear when the intestine is distended while others are permanent, and when examined it presents a soft, velvety appearance because of the presence on it of an enormous number of minute, fingerlike projections called villi (fig. 31). The villi contain small blood capillaries and lymph ves- sels, called lacteats, and play an important part in the process of digestion by collecting digested food products. In the mucous lining are also many simple glands which secrete a digestive fluid, the intestinal juice. The small intestine opens into the large intestine through the ileoccecal orifice at the junction of the caecum with the ascending colon. This opening is guarded by a valve called the ileoccecal valve which prevents the regurgitation of contents of the large into the small intestine. The valve consists of two cresent-shaped segments or folds that project into the caecum and are continuations of the walls of the ileum. The muscle fibers in these segments keep the opening which lies between them closed except during the passage of digested food from the small into the large intestine. The large intestine begins on the right side about 2y2 inches below the ileocaecal junction and extends to the anus. It is about 5 feet long, is larger in diameter than the small intestine, and is divided into the following parts: ANATOMY AND PHYSIOLOGY 55 the ccecum; the ascending colon, which curves at the lower border of the liver to form the hepatic flexure; the transverse colon which crosses the abdomen from right to left to the splenic region where it curves downward, forming the splenic flexure; the descending colon, which descends to the brim of the pelvis over which it curves to form the sigmoid flexure; and the rectum, the terminal dilated portion of the intestine that communicates with the outside through the anal orifice. The walls of the large intestine are arranged in the same manner as those of the small intestine, and are of the same structure, except that the longitudinal muscle fibers of the large intestine are arranged in three Capillaries Lymph trunk Lymph trunk Figure 31.—Villi of small intestine. (Cadiat.) • Lymphatic plexus bands which extend the entire length of the colon and are a little shorter than the colon, thus causing the walls to pucker. The mucous lining of the large intestine is smooth and contains no villi, but secretes a mucus which lubricates the tube. At the blind end of the caecum is a small worm-like projection called the vermiform appendix which is the seat of the pathological condition known as appendicitis. This concludes the description of the structures and organs comprising the alimentary canal and the accessory organs of digestion which have not been discussed will now be considered. The liver is the largest gland in the body and weighs from 50 to 60 ounces in the normal adult (fig. 32). This organ measures 8 to 9 inches from side to side, 4 to 5 inches perpendicularly, and 6 to 7 inches from front to back, is located in the very upper part of the abdomen, directly beneath the diaphragm, more of it lying to the right side than to the left, and is held in position by ligaments which are formed by the peritoneum. Its general shape is that of 56 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY a wedge, much thicker at the right than at the left, and with the thin edge turned forward. The upper surface of the liver is convex, conforming to the dome shape of the diaphragm. The lower surface is irregular and contains many fissures and fossae. The liver is divided into five lobes by five fissures, the largest of which' is the transverse fissure, through which the vessels, ducts, and nerves enter and leave the organ. The liver has a double blood supply, one being from the hepatic artery of the systemic circulation, and the other from the portal vein carrying absorbed food mate- rial from the intestine. The drain- age for both sets of capillaries is the hepatic vein which empties into the inferior vena cava. The liver is made up of many minute lobules of liver cells arranged concentric- ally about a central vein, which is a small venule of the hepatic vein. The lobules are held together by connective tissue which contains the capillaries of the hepatic artery and the portal vein, as well as the bile ducts, and the blood from these vessels comes in close asso- ciation with the liver cells in order to reach the central venule. In the gall-bladder fissure on the lower surface of the liver is the gall-bladder, a small, muscular, pear-shaped sac about 3 to 4 inches long which serves as a reservoir for the bile. Bile is partly an excretion which carries off certain waste products, and partly a secretion that plays an important part in the absorption of fats, and has been thought to limit putrefaction in the intestine to some extent. It is a thin, watery or a viscid, golden-yellow or dark olive colored liquid with a specific grav- ity varying from 1.050 to 1.10, a feebly alkaline reaction, and a complex composi- tion. It is secreted normally in amounts of from 500 to 800 cc per day and contains a pigment, bilirubin, which is derived almost entirely from the break- down of haemoglobin in the liver. Although formed more or less continually in the liver cells, bile enters the intestine only during periods of digestion, being prevented from entering at other times because the opening of the com- mon bile duct is closed, and it therefore backs up into the gall-bladder. Bile is collected from the liver cells by the biliary ducts which unite and gradually form larger and larger ducts that finally end in two main ducts which leave the liver and immediately join together to form the hepatic duct. The hepatic duct is soon joined by the cystic duct from the gall-bladder to form the common bile duct which enters into the duodenum with the pancreatic duct. The functions of the liver are important and numerous and are as follows: 1. Bile secreting.—It manufactures and secretes bile. 2. Glycogenic.—It manufactures glycogen from monosaccharides brought to the liver from the digestive tract by the portal vein. Glycogen is stored in the liver and is reconverted into dextrose by the action of a special enzyme at such times as body activities require it. Because it has the same chemical formula as the general one given to starch (CoBboOsK glycogen is sometimes called “animal starch.” 3. Storing of fat.—A certain amount of fat may be stored within the liver cells. Figure 32.—The liver. (Cunningham modified) ANATOMY AND PHYSIOLOGY 57 4. Urea producing.—Takes up nitrogenous waste products from the blood and converts them into urea, which is discharged back into the blood stream for elimination by the kidneys. 5. Removes by means of the bile certain other waste products, such as broken- down red corpuscles, disintegrated liver cells, and bile pigments. 6. The liver is considered as the source of fibrinogen and prothrombin. This organ is the site of origin of blood cells in the embryo. The pancreas is a compound gland, long and irregularly prismatic in shape, and situated in the abdomen behind the stomach at about the level of the second lumbar vertebra (fig. 33). It has a head, which lies in the concavity Figure 33.—Pancreas. (Mason, modified.) of the duodenum, a neck, a body, and a tail, which touches the spleen. It is about 5 to 8 inches long, the three surfaces of the body are each about 1*4 inches wide, and it secretes the pancreatic juice, a digestive fluid which is one of the chief agents in intestinal digestion, and is carried to the duodenum by the pancreatic duct. Beginning in the tail of the gland this duct runs from left to right through the body and neck into the head where it leaves and enters into the duodenum with the common bile duct. During its course through the gland the pancreatic duct receives tributary ducts from all portions of the gland and increases in size until, near the duodenum, it is about as large as a goose quill. In the connective tissue between the lobules of the gland are small areas of modified glandular tissue having no ducts which are known as the Islands of Langerhans and secrete a substance which is discharged directly into the blood stream. The function of this secretion will be described in the section on ductless glands. The process of digestion. Before describing the process of digestion the substances used as foods must be briefly considered. Foods are those substances necessary to maintain the normal composition of the body by building up tissue or, by oxidation, supplying heat and energy. Foods include: 1. Water; 2. Inorganic salts, principally of sodium, calcium, potassium, magnesium, and iron; 8. Vitamins, organic chemical compounds essential to normal life and growth; 4. Proteins, nitrogen-containing substances, chiefly lean meats and leguminous vegetables; 5. Carbohydrates, starches and sugars; and 6. Fats, animal and vegetable oils and fats. 58 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Water, inorganic salts, and vitamins are substances essential to life but have no energy-producing properties. Water and inorganic salts are necessary to maintain the normal composition of the tissues and complete withdrawal of either would cause the death of the organism. Vitamins are essential, in some as yet unknown way, to normal metabolism. The body’s energy is derived from the proteins, carbohydrates, and fats, complex organic substances whose chemical structure is known in whole or in part. After being eaten these substances must undergo various chemical changes, generally spoken of as metabolism, before they can be utilized by the body. These chemical changes take place during the jirocess known as digestion, break up the complex mole- cules of the substances into forms that the tissue cells are adjusted to act upon, and are attended by the production of heat. Foods are more fully discussed in the chapter on Diets and Messing for the Sick. The process of digestion begins in the mouth and ends in the small intes- tine and is both mechanical and chemical. The mechanical features of the process include the chewing and grinding of the food, the passage of the food along the alimentary canal by muscular action, and the mixing of the food and its dilution and solution in aqueous secretions. The chemical changes that take place in food during digestion are brought about by the action of sub- stances in the digestive fluids called enzymes, or digestive ferments, the latter term being used because they act upon foods used by the body. In the definition for these substances given at the beginning of this section it is stated they effect the transformation of other compounds by catalytic action. By catalytic action, or catalysis, is meant a reaction or change pro- duced in a substance by contact with another sitbstance called the catalytic agent or catalyst which itself appears to remain unchanged as a result of the reaction it has produced. As the enzymes which bring about the changes in foods necessary for them to be used by the body are produced in living body cells they could well be termed organic catalysts. The chemical composition of enzymes is complex, uncertain, or unknown, and although they all apparently contain nitrogen, and most of them sulfur, aboxit all that can be said positively in regard to their chemical structure is that they are organic substances derived from living cells and are colloids or so closely associated with colloids that they have not been isolated in a noncolloidal state. The action of enzymes is specific to a high degree, a given enzyme attacking only a certain compound or group of compounds. Consequently the enzymps that act upon carbohydrates cannot affect proteins or fats, those acting on proteins cannot affect fats, etc. Even closely related substances such as malt- ose and lactose seem to require their own specific enzyme. The enzymes concerned in human digestion and nutrition are classified according to the nature of the substances upon which they act, the principal classes being shown in the following table: Classes of Enzymes Name Action Example Proteolytic Amylolytic . Protein splitting - Pepsin of gastric juice; trypsin of pancreatic juice; erepsin of pancreatic and intestinal juices. Ptyalin of saliva; amylase of pancreatic juice. Lipase of pancreatic juice, of liver, connective tissue, etc. Maltese of saliva and of intestinal juice; invertase of intestinal juice; lactase of intestinal juice. Rennin of gastric juice. Lipolytic- Pat splitting - Glycolytic-. Sugar splitting Coagulating Convert soluble to in- soluble proteins. ANATOMY AND PHYSIOLOGY 59 In the table which follows the enzymes that take part in the process of digestion are arranged in groups under the class title of the substances on which they act. Name Chiefly found in Action Acting on carbohydrates: Piyalin___ Converts starch to sugar (maltose). Do. Converts cane-sugar to dextrose and levulose. Converts maltose (malt sugar) to dextrose. Converts lactose (milk sugar) to dextrose and galactose. Splits fats into fatty acids and glycerin. (Some of fatty acid and alkali forms soap which emulsifies fat.) Converts proteins to peptones and proteoses. Splits proteins, peptones, and proteoses into amino-acid compounds. Splits amino-acid compounds into their constituent amino-acids. Precipitates casein from caseinogen and makes the curd of milk. Amylase - Invertase . Intestinal juice. Maltase Lactase- Saliva, intestinal juice, pan- creatic juice. Acting on fats: Lipase (steapsin) Pancreatic juice-. ... Acting on proteins; Pepsin - .. Trypsin Pancreatic juice .. Erepsin Pancreatic juice, intestinal juice. Gastric juice Rennin.__ In the process of digestion, food is first taken into the mouth where mastica- tion takes place. This is accomplished by the teeth and the lower jaw and after this mechanical dividing or grinding the food presents a larger surface for the action of the saliva. During mastication the saliva pours into the mouth from the salivary glands and is mixed with the food through the movements of the tongue and the muscles of the cheeks. This moistens and softens the food, and starch is converted into sugar through the action of the salivary enzymes, ptyalin and maltase. As found in the mouth, saliva is a colorless or opales- cent, turbid, and viscid liquid with a specific gravity of about 1.003 and a neutral or slightly acid reaction. The enzyme pytalin converts starch to mal- tose (malt sugar), and maltase breaks up the maltose into dextrose. The presence of food in the mouth and the sight and smell of appetizing foods act as nerve stimuli to increase the amount of saliva necessary for mouth digestion. The food taken into the mouth has there been reduced to a consistency suit- able for swallowing and has been formed into what is known as a bolus. By deglutition, or swallowing, the bolus passes from the mouth to the pharynx and thence into the oesophagus through which it is carried into the stomach. The act of swallowing is largely voluntary but the final stage and the pas- sage of the bolus through the pharynx and oesophagus is the result of involun- tary muscular action. The musculature of the oesophagus causes a contrac- tion of the tube to occur immediately after the passage of the bolus which follows the bolus from above downward like a wave, finally forcing it through the cardiac opening of the stomach. This wave-like contraction is called peristalsis. In the stomach the food which has been swallowed is thoroughly mixed with the gastric juice by muscular movements of the stomach walls. These movements, somewhat peristaltic in character, not only mix the food and the gastric juice but eject the liquefied portions of the food into the duodenum. As digestion proceeds in the stomach the food becomes a thin, liquid mass known as chyme, which periodically passes through the pylorus into the duo- denum. In the mucous membrane of the stomach are myriads of simple glands called gastric glands which secrete the gastric juice, a thin, colorless or nearly color- 1542940—39 5 60 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY less liquid with a specific gravity of about 1.002 to 1.003, a strongly acid reaction because of the presence in it of hydrochloric acid, and a characteristic odor. Two enzymes, pepsin and rennin, and perhaps a third, lipase, are found in the gastric juice. The flow of gastric juice occurs partly in response to nerve impulses sent to the stomach as a result principally of the sensory impressions of taste and smell received in the brain, and partly by the presence of chemical substances in the stomach itself. Hard work should not be performed or strenuous exercise taken immediately after eating as this retards digestion in the stomach chiefly by checking the flow of gastric juice, with gastric distress and possibly vomiting as a result. Nor should a hearty meal be eaten when physically exhausted because the nervous, circulatory and digestive systems can- not properly perform their parts in the process of digestion. The food on mix- ing with the gastric juice becomes acid in reaction. The hydrochloric acid in the gastric juice stops the action of pytalin, aids in coagulating proteins, activates the enzyme pepsin which is secreted in an inactive form, pepsinogen, and seems to favor relaxation of the pyloric sphincter, which remains closed after each ejection of chyme until the acidity of the ejected chyme in the duodenum has been neutralized. The enzyme pepsin prepares the proteins of the food for complete digestion by breaking them down into simpler chemical compounds known as peptones and proteoses. Rennin, which is present in many persons only during early life, precipitates casein from the caseinogen in milk and causes the milk to clot, or curdle, and form a curd. Lipase, which when present is in small amounts, has very little activity in the stomach, its action probably being the splitting up of the finely emulsified fat found in milk. The chyme on passing into the duodenum from the stomach consists of water, inorganic salts, partially digested foods, and the indigestible portion of meats, cereals, and fruits. The acid character of the chyme causes the secretion and discharge of the intestinal fluids secreted by glands in the mucous membrane of the duodenum and of the small intestine, the pancreatic juice, and the bile. The intestinal fluids, which are alkaline in reaction, exert a neutralizing and precipitating influence on the various constituents of the chyme and as soon as this occurs gastric digestion ends and intestinal digestion starts. Beginning in the duodenum, intestinal digestion is largely completed by the time the food reaches the ileo-csecal valve and produces the important changes in the food necessary for its absorption. In intestinal digestion the partially digested food received from the stomach is subjected to the action of the pan- creatic juice, the intestinal juice, and the hide. These secretions mix with the food from the duodenum on and they act at the same time. The pancreatic juice in man is a thin, limpid liquid with a specific gravity of about 1.0075 and an alkaline reaction. It is undoubtedly the most important digestive fluid in the body and contains four enzymes, trypsin and erepsin, proteolytic enzymes, amylase (also known as amylopsin), a starch-splitting enzyme, and lipase (also known as steapsin), a fat-splitting enzyme. Trypsin, like pepsin, is secreted in an inactive form trypsinogen, which is activated by enterokinase, a constituent of the intestinal juice. The erepsin in the pan- creatic juice is similar to that in the intestinal juice. Lipase is aided and facilitated in its action by the presence of bile. The action of the pancreatic enzymes is shown in the table on page 59. Human bile plays an important part in the digestion and absorption of fats as it accelerates the action of lipase and perhaps of amylase, and helps in the neutralizing of the hydrochloric acid of the gastric juice. It is also considered to aid in lubricating the intestine to facilitate the passage of indigestible and waste matter. 61 ANATOMY AND PHYSIOLOGY Peristaltic movement forces the contents of the small intestine along until finally they enter the large intestine through the ileo-csecal valve, at which time digestion is virtually complete. When the contents of the small intestine enter the large intestine they contain some unabsorbed food material, and, as they also contain digestive enzymes received in the small intestine, it is probable that digestion and absorption continue for a time in the large intestine. The indigestible waste material, combined with certain waste substances from the bile and intestinal secretions, passes slowly along the large intestine by peristaltic movement and rapidly loses its water content by absorption until, by the time it reaches the descending colon it has acquired the consistency of fceces. When the faeces reach the terminal portion of the large intestine they are ready to be expelled from the body by the act of defaecation. By digestion the carbohydrates, proteins, and fats contained in the various foods that have been eaten have been changed into substances of simpler chemical composition. Starches and compound sugars have been changed into simple sugars, proteins have been broken down into their constituent amino- acids, and fats have been finely emulsified and split into fatty acids and glycerin, all of which are forms suitable for absorption. In physiology absorption is a term to describe the passage of digested foods from the alimentary canal into the blood or lymph. The absorption of food takes place principally from the small intestine. There is some food absorption and a large absorption of water from the large intestine, and little or no absorption from the stomach. Absorption from the small intestine takes place by two paths: 1. By the capillaries of the villi to the blood stream; and 2. By the lymphatics to the thoracic duct and the superior vena cava. The products of fat digestion are taken up chiefly by the lymph capillaries, or lacteals, in the villi and carried by the lymph stream into the thoracic duct and finally into the blood stream at the junction of the left Internal jugular and the left subclavian veins. A small amount of fat is absorbed by the blood capillaries, part of which is appropriated by the liver for its own use and storage. The products of protein and carbohydrate digestion are taken up by the blood in the capillaries of the villi and carried through the portal circula- tion to the liver. In the liver the excess of dextrose (simple sugar) is with- drawn and changed to glycogen by the action of the liver cells, the amount of sugar in the blood remaining constant. Some of the amino-acids are also converted to glycogen by the action of the liver cells with the formation of urea, which is carried in the blood to be excreted by the kidneys. The glycogen is stored in the liver to be liberated again as dextrose when needed by the body. THE SPLEEN AND OTHER DUCTLESS GLANDS The term ductless glands is applied to those organs whose function is to produce special secretions containing hormones, which are discharged into the blood or the lymph. These organs are also called endocrine glands or glands of internal secretion and, as previously stated, are of glandular structure and have no ducts. A hormone is a chemical substance produced in a more or less distant organ which, carried by the blood or lymph to a functionally associ- ated organ, excites the latter to activity. The glands generally spoken of as ductless glands are the thyroid, the parathyroid, the thymus, the suprarenals, the pituitary iodyr or hypophysis, and the pineal body, or epiphysis. The spleen, though it has no ducts, has not been found to have an internal secre- tion, and therefore, while anatomically a ductless gland, physiologically it is not a gland of internal secretion. Some other glands in the body that have 62 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY ducts, as the pancreas and the gonads (testes in the male, ovaries in the female), also form internal secretions that are discharged directly into the blood and therefore act as ductless glands in addition to their more obvious functions. There are a few other ductless glands which will not be described in this section. The spleen is situated in the upper left part of the abdomen directly beneath the diaphragm in front of the upper part of the left kidney and behind and to the left of the stomach. Its border is roughly oval or circular in outline, its size varies greatly, and its average weight is from 5 to 8 ounces. It is a soft, highly-elastic, contractile organ, purplish in color, and composed of a fibrous capsule containing a soft substance called pulp in which nodules of lymph tissue are embedded. There are no capillaries in the spleen, the blood escaping from the arterioles into the pulp and being collected from the pulp by the small venules. The spleen is known to be active in the destruction of defective blood cells, both red and white, as well as being the source of some of the lymphocytes of the blood stream. It undoubtedly has othen functions not now definitely known. In some diseases, as chronic malaria, it becomes greatly enlarged. The thyroid gland is a highly vascular body situated anteriorly in the neck at the junction of the trachea with the larynx, and its tissue consists of spherical vesicles lined with epithelium and containing a fluid called colloidal material. It is composed of two conical lobes connected across the median line by a narrow strand of gland tissue called the isthmus, one lobe lying on each side of the larynx and extending upward. The gland secrets a sub- stance called thyroxin which contains a large percentage of iodine and has a marked influence on body growth and on nervous stability. Complete removal of this gland, leaving the parathyroids uninjured, does not cause death but does cause marked changes in metabolism and is usually followed by a state of chronic malnutrition or cachexia. Cretinism is the result of a congenital defect or atrophy of the thyroid gland, which causes the arrest of skeletal and mental development. On atrophy of this gland in the adult, a similar phenomenon called myxcedema results, the body becomes puffed and pasty, and the mentality blunted. In hyper-thyroidism, or goiter, there is an extreme nervousness, increased metabolism, quickened heart action, and in some cases protrusion of the eyeballs (exophthalmos). The parathyroids, usually four in number, are small grain-like bodies located on or near the posterior surface of the lobes of the thyroid, two on each side. The internal secretion which they furnish regulates calcium metabolism which is so essential in bones, blood, and other tissues, and is believed to aid in neutralizing certain toxic substances. Complete removal of the parathyroids is followed by acutely toxic results, muscular tetany, and death. The thymus is located in the thorax posterior to the sternum and varies greatly in size in different individuals and at different ages. It is considered to consist of two lobes, one on each side of the midline, and to reach its maximum size in childhood. While it undergoes atrophy after puberty it does not entirely disappear. Its function is obscure but it is believed it exerts an influence on body growth and the development of the reproductive organs. The suprarenals, or adrenal glands, are two flattened bodies situated in the back part of the abdomen which lie like caps over the upper pole of each kid- ney. These glands consist of two portions, an inner, highly vascular mass of tissue called the medulla enclosed within an outer portion, or capsule, of cor- tical substance called the cortex. The cortex in turn is surrounded by a capsule of fibrous tissue. Each portion has a separate secretion and function. The ANATOMY AND PHYSIOLOGY 63 secretion of the medulla, adrenalin, or epinephrine, is the better known and has a marked effect on the tone of the heart and the blood vessels. It increases blood pressure by constricting the blood vessels and slowing and increasing the force of the heart beat. Its constricting action on blood vessels causes it to be used in controlling haemorrhage. Cortin, the secretion of the cortex, regulates important phases of the mineral and water metabolism of the body, and appears to be of great value in the treatment of Addison’s disease. From the cortex was first isolated the substance known as ascorbic acid, which is the antiscorbutic vitamin 0. Removal of the cortex results in death. The pituitary body, or hypophysis, is a small, oval-shaped gland attached to the base of the brain and situated in a depression in the sphenoid bone. It consists of an anterior lobe of glandular structure and a posterior lobe com- posed chiefly of connective tissue, blood vessels, and nerve cells and to which a glandular portion, the pars intermedia, is attached. The anterior lobe is larger than the posterior, which it partly encircles, and has been called the “master gland” as it appears to influence the activity of most of the other glands of internal secretion. This gland, though its size is small and its gross structure simple, has the most complex function of the glands of internal secretion. In its secretion are a great number of hormones, some of which are far from being definitely identified. In the anterior lobe, hormones influenc- ing sex, growth, thyroid metabolism, and carbohydrate metabolism are known to be present, and in the posterior lobe hormones stimulating contractions of non- striated muscles, constricting arteries and raising blood1 pressure, and with anti-diuretic action have been found. Over or under production of the growth principle in the secretion of the anterior lobe results in pituitary giants or dwarfs. The pineal body, or epiphysis, is a small, fir-cone-shaped gland about the size of a cherry stone situated near the pituitary body but above and back of it. Little is known of the function of the pineal gland, but the general conclu- sion from evidence now at hand is that it has an internal secretion which counter- acts at least some of the functions of the pituitary, particularly the stimula- tion of the gonads. It is also necessary for the development of the eyeball, very small eyes occurring in its absence. The pancreas, mentioned elsewhere as producing digestive enzymes, also pro- duces, from areas of specialized tissue called the Islands of Langerhans, a hormone called imulin, which like other products of the glands of internal secretion, is poured directly into the blood. Insulin is essential in the regula- tion of carbohydrate metabolism. An insufficiency, relative or absolute, results in the condition called diabetes. The gonads, sex glands, male, testes, and female, ovaries, each produce, in addition to reproductive cells (spermatozoa and ova), an internal secretion which is responsible for the development of appropriate secondary sex charac- teristics in the individual. THE EXCRETIONS. The waste products resulting from the activities of the body are called excretions and are discharged to the exterior by organs known as excretory organs, some of which are arranged in systems. The discharge of the waste products of the body is called excretion and takes place by means of: 1. The urinary system, which eliminates water, and certain organic and inorganic waste products; 2. The skin, which eliminates water, organic and inorganic waste materials by means of perspiration; 3. The lungs, which eliminate cer- tain gaseous waste products, such as carbon dioxide, water vapor, and small 64 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY amounts of nitrogen; and 4. The alimentary canal, which eliminates the residue remaining after digestion and the waste products discharged into it. Normal urine of man varies in color from a pale yellow to a brownish hue, is acid in reaction, and has a specific gravity ranging from 1.015 to 1.025. The color varies according to the quantity excreted, being pale or light when the quantity is large, and dark when the quantity is small and the concentration of solids is greater. Various foods and medicinal substances also affect the pe. The pelvis of the kidney. cor. The cortex, the part between the cortex and the pelvis being the medul- lary portion. pyr. Pyramid. ca. The calices. m. r. The medullary rays. U. The ureters. B. The bladder. 0. u. The ureteral openings. 1. u. m. The internal urinary meatus. o. e. d. The openings of the ejaculatory ducts in the prostatic urethra. g. u. s. The genitourinary sinus. v. m’. The veru montanum. b. u. The bulbous urethra. d. c. Openings of the ducts of Cowper’s glands. c. c. Corpus cavernosum. c. s. Corpus spongiosum, u. Urethra. f. n. Fossa navieularis. e. u. m. External urinary meatus. Figure 34.—Anterior view of the opened genitourinary tract in the male. (Guiteras.) color of the urine. The degree of acidity varies at different periods of the day and is affected by the character of the individual’s food or by medicinal substances taken. The average daily output is from 40 to 50 fluidounces but may be more or less, depending upon many factors, among which may be mentioned atmospheric temperature, the intake of fluids, disease, medicinal substances taken, and other types of elimination of fluids, as in haemorrhage, perspiration, diarrhoea, and vomiting. Urine has a characteristic odor which is influenced by disease, vegetable foods, and other substances. The chemical composition of urine is very complex and is determined partly by tissue metab- olism and partly by the quantity and quality of foods consumed and metabo- ANATOMY AND PHYSIOLOGY 65 lized. Ordinarily it is composed of about 95 per cent of water and 5 per cent of solids comprised of nitrogenous waste products and organic and inorganic salts. The chief nitrogenous constituent of urine is urea which is present to the extent of about 2 per cent. Other nitrogen compounds are present in minor quantities. The inorganic salts are those of sodium, calcium, ammonium, potassium, and magnesium, the organic salts are lactates, acetates, and small amounts of formates. Certain abnormal constituents as albumin, sugar, indi- can, acetone, casts, and blood may be found under pathological conditions. The urinary system consists of the kidneys, the ureters, the bladder, and the urethra (fig. 34). The kidneys are two large, glandular organs situated in the posterior part of the abdominal cavity, behind the peritoneum, one on each side of the lower, SUBSTANCE- DEOULLARV SUBSTANCE -PAPILLA, RENAL VEINS RENAL ARTERIES • HILUn SINUS Figure 35.—Section of kidney. (U. S. Naval Medical School.) movable portion of the spinal column. They extend from about the level of the twelfth thoracic to that of the third lumbar vertabrse, the inferior end usually being from I1/) to 2 inches above the highest part of the crest of the ilium, and the right kidney slightly lower than the left. These organs (fig. 35) are bean-shaped and each is about inches long, 2 inches wide, and 1% inches thick. On the concave side of each is a deep, notch-like depression called the hilum, through which the blood vessels and nerves enter and leave the kidney. The hilum extends inward into the kidney to form the narrow space known as the sinus of the kidney. Each kidney is surrounded by a thin fibrous capsule and lies embedded in a mass of soft fatty tissue. The parenchyma, or special- ized glandular tissue, of the kidney is dense and friable, and consists of an inner portion called the medullary substance, or medulla, and an outer portion called the cortical substance, or cortex. The medullary substance surrounds the sinus of the kidney and appears largely in the form of conical masses known as renal pyramids, or pyramids, whose apices project into the sinus to form 66 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY small conical elevations called renal papillae, or papillae, whose rounded ends are pierced by minute openings called foramina papillaria that are the terminal apertures of the tubules of the kidney. Two or three and sometimes six or more pyramids end in one papiha, which number from 6 to 18 and cause the iloor of the sinus to be uneven. The bases of the pyramids are covered and also separated from the surface of the kidney by a layer of the cortical sub- stance of the kidney, which also extends inward towards the sinus, between the pyramids, in columns known as renal columns. In the cortical substance are an immense number of tubules called uriniferous tubules and thousands of small structures known as Malpighian bodies or renal corpuscles (fig. 36). These bodies are located in the cortical substance of the kidney and consist of an outer, spherical- shaped, membranous sac called Bowman's capsule, and an inner, minute, convoluted coil of blood capillaries called the glomerulus (fig. 36). Bowman’s capsule is an expansion of the uriniferous tubule and its membranous wall folds in so that its outer surface becomes an inner surface, as when one part of a hollow rubber ball is pushed inward. Through the opening made by the infolding of the wall a small artery enters and divides into a number of capillaries which coil and twist about to form the glomer- ulus and later unite in a single small vein that passes out through the same opening. The infolded wall of Bowman’s capsule adheres to the capillaries of the glomerulus, closely covering them and dipping into the spaces between the small coils of the glomerular capillaries. From Bowman’s capsule the uriniferous tubule immediately continues through the cortical and medullary substances until it terminates in the opening in the papilla with which it communicates. The uriniferous tubules, which may be roughly separated into a secreting part lined with several types of epithelial cells and a collecting part, are partly convoluted and partly straight and regular, and run a very complicated course before the collecting part begins in the pyramids. The collecting part of the tubule in the pyramids is straight and empties into the kidney pelvis, there discharging the urine collected. The blood supply of the kidneys is through the renal ar- teries which give off branches that, as they pass through the kidney substance, divide repeatedly into smaller branches each of which, with a few exceptions, ends in a glomerulus. The venous return is by the renal veins. The function of the kidneys is to remove certain waste materials from the blood and excrete them in the aqueous solution known as urine, thereby pre- venting the waste materials from accumulating in the blood and keeping its composition constant. They also play an important part in maintaining the normal, slightly alkaline reaction of the blood by excreting enough of sub- stances in the blood that might alter its reaction to reduce their quantity to Figure 36.—Schema of a renal pyramid show- ing enlarged nriniferous tubule, glomeruli, and blood supply, with further magnification of a glomerulus. (U. S. Naval Medical School.) ANATOMY AND PHYSIOLOGY 67 the normal level. For example, should the reaction of the blood tend to become too alkaline, the kidneys will excrete more alkali in the salts in the urine. Also, when the presence of more acid substances in the blood tends to make its reaction less alkaline, they excrete more acid. Likewise, although its removal is not concerned with the reaction of the blood, the kidneys will remove all excess sugar present in the blood. Through the kidneys the greatest part of nitrogenous waste products is excreted, that excreted elsewhere being almost negligible in quantity. The process by which substances are removed from the blood and excreted in the urine is not definitely known but the generally accepted theory is that it is a process of filtration, reabsorption, and secretion. All the substances present in the blood plasma except protein filter through the infolded wall of Bowman’s capsule into the sac-like cavity communicating with the uriniferous tubule The liquid that seeps through the capsule is known as the filtrate and consists of blood plasma without any protein. This filtrate as it passes along the course of the uriniferous tubule becomes altered in composition by the selective action of the epithelial cells lining the tubule. The selective action of the epithelium of the tubule consists very largely of a reabsorption of those substances that, at the time, are needed by the blood to maintain its normal composition, i. e., a composition having the proper aqueous dilution, the proper acid-base balance, the proper sugar concentration, etc. Also, by this mechanism those substances that are not needed in the operation of the body metabolism are thrown oft. Whether or not a certain substance is needed at a given time depends on conditions within the body at that time. Thus, when the body needs water, as may occur as a result of limited intake or from increased loss through sweating, diarrhoea, or copious vomiting, more water is reabsorbed from the filtrate and as a result the urine contains less water and its specific gravity rises. On the other hand, when the body has an excess of water, the urine contains more water and its specific gravity lowers. Similarly, if the body has need of sodium chloride that substance is selected out and reabsorbed from the filtrate in the tubule with the result that little is excreted in the urine. This occurs particularly when sodium chloride is absent from the diet. Also, ail sugar in the filtrate is normally reabsorbed in the tubule with the result that none is excreted in the urine. In blood plasma there is normally about 0.03 per cent of urea present while in urine there is nearly 67 times as much, or about 2.0 per cent. This great increase is largely due to concentrating the urea contained in a very large amount of filtrate in a relatively small amount of urine. In addition to the absorption taking place in the uriniferous tubule there is good experimental evidence showing that the epithelium which lines the tubule actually secretes some of the urinary constitutents, particularly the ammonium salts found in urine. Besides removing from the blood the waste products of normal body metahol- ism the kidneys also are able to remove surprisingly large amounts of foreign substances of a poisonous nature that may find their way into the blood stream. Outstanding examples of substances so removed are mercury, various barbituric- acid derivatives, and alcohol. Most medicinal substances given in treatment are ultimately eliminated from the body through the kidneys. These activities of the kidneys show them to be organs extremely vital to the well-being of the body. If they fail to perform their vital functions, the composition of the urine changes, substances that should be are not removed from the blood, and those substances rapidly build up to a concentration in the blood that results in toxic conditions. One of the most familiar conditions 68 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY manifesting a disturbance of kidney function is albuminuria which occurs when Bowman’s capsule fails to prevent protein from passing through it. When waste products are retained in the blood because of failure of the kid- neys to remove them, they quickly build up to a concentration in the blood that produces toxic effects. The acid-base balance is seriously disturbed and an excess of urea and other waste products accumulates. This condition is known as uraemia. The ureters (fig. 35) are two musculo-membranous tubes about 15 to 18 inches long, that begin above in a thin-walled, funnel-shaped expansion called the pelvis which lies partly within and partly without the sinus of the kidney. The part outside of the sinus gradually decreases in size until at about the level of the inferior end of the kidney its diameter is about that of a goose quill. The part within the sinus contains several cup-like divisions called renal calyces, or calyces, which enclose the papillae and receive the urine, which enters them through the openings in the papillae. The ureters connect the kidney and the bladder, leaving the kidney at the hilum and entering the bladder at the lower and back portion of the organ, where they deliver to the bladder the excretion of the kidneys. The course of the ureters through the muscular walls of the bladder is oblique so that when the bladder is distended the coats of the ureters are approximated in such a manner that regurgitation of urine from the bladder is prevented. The urinary bladder (fig. 34) is a musculo-membranous sac situated in the pelvis just behind the pubis, and does not, under normal conditions, extend above the upper border of the symphysis. It acts as a reservoir for urine until such time as micturition is convenient. When moderately distended the bladder holds about 1 pint. Upon the inner surface of the bladder in the upper part, or fundus, the mucous membrane is thrown into folds or rugae. The lower portion presents a comparatively smooth triangular surface, known as the vesical trigone, outlined by the openings of the two ureters and the urethra. Micturition, or the act of voiding urine, is an involuntary mechanism con- trolled partly by volition. The urethra (fig. 34) is a membranous tube passing from the bladder along the under surface of the penis to the distal end of that organ where it terminates in the meatus. It serves to convey the urine and, in the male, the secretions of the genital glands, to the exterior. In the male it is about 8 inches long, and is divided into three parts, the prostatic, the membranous, and the penile portions. The prostatic urethra, about 1 inch in length, is surrounded by the prostate gland and contains the orifices of the prostatic and the ejaculatory ducts. In this portion the diameter of the urethra is the largest. The mem- branous urethra is about one-half inch in length and consists of that portion which pierces the urogenital diaphragm. The penile urethra is the longest portion and lies along the base of the penis, extending to its external opening, the urinary meatus. (See section on Genito-urinary and Venereal Diseases.) The perspiration, or sweat, excreted by the sweat glands of the skin, is a clear, colorless, watery liquid with a specific gravity of about 1.004 and a slightly acid reaction. It has a salty taste and a distinctive, rancid odor or none at all. Perspiration is excreted continuously, taking place so gradually that it evaporates as fast as it is formed when it is known as insensible perspiration, or, under exposure to great heat and exercise, so rapidly that evaporation does not take care of it, and it is then known as sensible perspira- tion. Normally about 1 quart of this fluid is excreted daily, but the amount varies widely with atmospheric temperature and humidity, and the amount ANATOMY AND PHYSIOLOGY 69 of exercise taken. It consists chiefly of water with small quantities of salts, fatty acids, urea, and carbon dioxide. The skin is a tough elastic membrane forming the outer covering of the body, and contains certain appendages as the hair and nails. Certain glands, as the sweat and the sebaceous glands, discharge their secretions upon the surface of the skin. (Fig. 37). The skin is made up of two principal layers, the epidermis, or cuticle, and the derma, or true skin (cutis vera). The epidermis consists of stratified squamous epithelium and may be divided into two layers, the superficial layer being horny and hard, and the inner layer, known as the germina- tive layer, consisting of soft protoplasmic cells. The derma is a highly sensitive and vascular layer of connective tis- sue, containing blood ves- sels, hair follicles, sweat and sebaceous glands, and nerve endings. The sweat glands are coiled tubular glands, the coils of which lie embedded in the derma and surround a small tuft of capillaries. These glands are located in the subcutaneous tis- sue and open by a duct upon the surface of the skin. The sweat glands serve as excretory organs, excreting the sweat or perspiration. The sebaceous glands are compound sacular glands, the ducts of which open about the hair shaft. These glands secrete an oily substance, sebum, which keeps the skin soft and pliable. The true skin is well supplied with specialized nerve endings which carry impressions of touch, heat, cold, and pain. The true skin also contains motor nerves to blood vessels, and secretory nerve fibers to the glands. The skin serves as a protective covering to aid in the preservation of body temperature, and as an excretory organ. It contains the nerve endings pre- viously mentioned. Figure 37.—Perpendicular section of skin. (Mason, modified.) THE MALE REPRODUCTIVE ORGANS The male genital organs consist of the testes, the epididymis, the scrotum, ductus deferens, seminal vesicles, prostate, bulbo-urethral glands, urethra, and the penis, (fig. 38). The testes are two glandular organs suspended from the inguinal region by the spermatic cord and surrounded and supported by a musculo-membranous sac covered with skin, the scrotum. The testicle proper is somewhat oval in shape and is composed of tubular glands held together by connective tissue. These glands form the male generative cells, the spermatozoa. The interstitial cells of the testis produce an internal secretion which promotes the development of 70 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY masculine characteristics. The tubules of the testicles unite to form a single tube which lies as a tortuous mass called the epididymis on the posterior sur- face of the testicle and connects with the ductus deferens. The ductus deferens or vas deferens, is the excretory duct of the testicle and runs in the spermatic cord through the inguinal canal into the abdomen, thence extra-peritoneally on a convergent course to the seminal vesicles. The sper- matic cord forms the pedicle of each testicle and extends from the internal abdominal ring to the back of the testis, and is made up of the ductus deferens, spermatic arteries and veins, lymphatics, nerves, cremasteric muscle and con- nective tissue. Figure 38.—Section through male generative organs and bladder. 1, Rectum, 2, prostate; 3, bulbo-urethral gland; 4, testicle; 5, glans penis; 6, urethra; 7, symphysis pubis; 8, bladder. (Manual of Surgical Anatomy, U. S. Army, modified.) The seminal vesicles are two glandular pouches between the bladder and rectum and unite with the ductus deferens to form the ejaculatory duct. These vesicles serve as a reservoir for the semen and add a secretion of their own. The ejaculatory ducts pass from the seminal vesicles between the lobes of the prostate gland and open into the floor of the prostatic urethra. The prostate gland is a partly glandular and partly muscular organ that sur- rounds the first portion of the urethra and resembles a horse-chestnut in form. The glandular and muscular tissue of this gland is surrounded by a dense fibrous capsule. It secretes a fluid which is an essential element of the semen. The bulbo-urethral or Cowper’s glands are two small bodies about the size of a pea situated one on each side of the membranous urethra and opening into it. They secrete a fluid which forms part of the seminal fluid. The penis consists of three more or less cylindrical bodies composed largely of erectile tissue. The two corpora caveruosa lie above the corpus spongiosum which contains the urethra. The glans penis, forming the distal end of the ANATOMY AND PHYSIOLOGY 71 penis, is continuous with the corpus spongiosum and contains the external opening of the urethra, the meatus, or urinary meatus. The covering of the shaft of the penis is loose skin, but that portion reflected over the glans penis is a thin layer of skin lined with mucous membrane, and is called the prepuce. The semen is a fluid made up of the secretions of the bulbo-urethral glands, the prostate, the seminal vesicles, and the testes. THE NERVOUS SYSTEM lit order that the subject matter which is to follow may perhaps be better understood it is considered advisable to briefly describe the means by which the lower forms of animal life react to different conditions. The lowest form of animal life, the unicellular animal organism such as the Amoeba, possesses no distinctive nervous system but adapts itself to its surroundings by reason of the property of irritability which is inherent in the protoplasm of which it is composed. The single-cell animal moves about and carries out its processes of metabolism and reproduction entirely within and by itself and always reacts in the same way to any specific stimulus. A little higher form of animal life, the Metazoon, has a soft, semifluid body of protoplasm consisting of groups of cells which stick together. Most of these cells, originally derived from a single parent cell, have lost their character- istics as individual cells and become specialized for certain functions. Some are specialized so that they link the different parts of the body of this water- dwelling animal together with a primitive nervous system which deals with outside impressions, brings about necessary movements, and controls various living activities. Other cells are specialized to form a supporting substance (primitive skeleton) and others are specialized to provide for movement (prim- itive muscles). In all parts of the outer supporting substance are cells which are specialized to receive external stimuli and are known as sensory or receptor cells. From the receptor cells extend two elongated portions called processes. One, the peripheral process, passes toward the surface and may even pass be- yond it, the other, called the central process, passes inward into the body and connects with a network of cells of the nervous system called connector cells. The connector cells communicate with each other by processes and have other processes reaching still deeper into the body and connecting with motor or effector cells which have processes distributed to the primitive muscles of the animal. There is thus provided a means by which a sensation or impression of danger received by a receptor cell can he carried to a connector cell and thence, through the network of connector cells, to a number of motor cells. As a result of stimulation of the motor cells there occurs a general response of the primitive muscles and the animal moves away from the point of danger. Such a general muscular response to a local stimulus is always the same if conditions are the same. In producing the movement just described three basic nerve elements have been shown to exist; 1. The receptor or sensory cell; 2. The network of con- nector cells; and 3. The motor or effector cells. These basic elements are found in the nervous systems of all forms of animal life higher than the Metazoon, with such modifications as are necessary to permit a particular type of animal to carry out its purpose in life. When the higher stage in animal life represented by the earthworm, or Lumbricus, has been reached there has evolved from the primitive nervous system one in which there is a central, controlling part quite distinct from a peripheral portion of nerve fibers carrying impulses to or from the central part. In the earthworm this central part consists of a nerve-cord running 72 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY longitudinally through the entire length of the body, in each segment of which the nerve-cord is slightly swollen or enlarged on each side. These enlargements are collections of nerve cells called ganglia from each of which bundles of nerve fibers called nerves pass off to each side. Some of these nerves are motor and are connected with muscles; others are sensory and end in receptor or sensory cells in the covering of the body. Close to the front end of the worm is located a single pair of ganglia called the cerebral ganglia which are connected with each other by a bridge of nerve fibers. From the side of each cerebral ganglion a strand of nerve fibers curves around the side of the worm’s alimentary canal and connects with the first ganglion of the nerve-cord. In the more highly developed animals the cerebral ganglia in the worm may be said to be represented by the brain, the nerve-cord by the spinal cord, and the ganglia on the nerve-cord by the pairs of spinal nerves. In the higher animals modification and evolution of the primitive nervous system of the Metazoon has proceeded to the point where a central nervous system consisting of the brain and spinal cord and a peripheral nervous system consisting of the spinal nerves have been developed. The primitive connector cells and their processes and the primitive motor cells without their processes have collected to form the central nervous system and ganglia on sensory nerves. Nerves have evolved, the processes of the primitive receptor or sensory cells forming sensory or afferent nerves which pass into the central nervous system while the processes of the primitive motor or effector cells have formed motor or efferent nerves which pass out of the central nervous system. If, for convenience, both sensory and motor nerve fibers are carried in the same nerve trunk, that nerve trunk is known as a mixed nerve. The cranial nerves arising from the brain and the spinal nerves arising from the spinal cord are typical examples of mixed nerves. With this evolution of the nervous system there have been developed special receptors for the functions of sight, smell, hearing, etc., and in the highest forms of animal life certain parts of the brain have enlarged to enable it to properly control the many complex functions and movements of the body containing that brain. The ability of the human organism to adapt itself to its surroundings or environment, to coordinate and regulate the activities of its various parts so that they wrork harmoniously together, and to reason, is due solely to the presence in it of nerve tissue, which, as previously stated, is the most highly specialized tissue in the body. This tissue is present in every part of the body in the form of nerve cells, small masses containing nerve cells called nerve centers, or ganglia, and conducting or connecting elements called nerve fibers, bundles of which are termed nerves. These forms collectively consti- tute the complex apparatus known as the nervous system, frequently spoken of as the “ruler of the body.” For purposes of study and description in this book, the nervous system will be considered as divided into three parts, the cerebrospinal or central nervous system, the peripheral nervous system, and the sympathetic nervous system. Also, for ease in study and description, the impulses carried by the afferent or sensory nerves will be termed impressions while those carried by the efferent or motor nerves will be termed impulses. The central nervous system consists of the brain, or encephalon, contained within the cranial cavity, and the spinal cord, or medulla spinalis, which occupies the upper two-thirds of the spinal canal. Together the brain and the spinal cord dominate the entire nervous system. The peripheral nervous system consists of 12 pairs of cranial nerves attached to the brain and 31 pairs of spinal nerves attached to the spinal cord. ANATOMY AND PHYSIOLOGY 73 These nerves are associated with the functions of the special and general senses and with the voluntary movements of the body. The sympathetic nervous system is often considered as part of the peripheral nervous system with which it is intimately connected and closely intermingled. It is also known as the autonomic, vegetative, and ganglionic nervous system. Nerve tissue is made up of nerve cells, or neurones, and their processes, held together, in the brain and spinal cord, by a special supporting tissue called the neuroglia and by ingrowths of the membrane covering the brain and spinal cord, the pia mater. The nerve cell, or neurone, is the unit of struc- ture and of function in the nervous system, varies in size, shape, and structure, and consists of the cell-body, or cyton, and one or more processes extending out from the body. Nerve cells having but one process are called unipolar cells, those having more than one, multipolar cells. The cell body, made of nucle- ated protoplasm, is the seat of origin of the changes which give rise to nervous impulses, and presides over the nutrition of the cell. The processes of nerve cells are outgrowths of the cell-body and. provide the paths along which nervous impulses are carried. They are of two kinds, the axone, or axis- cylinder process, a single, unbranched process which lengthens out to become the axis cylinder, or conducting part, of a nerve, and the dendrone, dendrite, or protoplasmic process, a short process that divides into smaller and smaller branches which terminate in free ends that become lost in the nervous tissue (fig. 39). The axones vary in length, some extending only a very short dis- tance beyond the cell while others continue to distant parts of the body. The longer processes, which usually acquire protective sheaths, are known as nerve fibers, and these, arranged in bundles, form the nerves, or nerve trunks, that pass to every part of the body. Nerve fibers are the conducting elements of the nervous system and bring the nerve cells into rela- tion with each other and with the various tissues of the body. They constitute the greater part of the brain and the spinal cord, make up the nerves, and are known as medullated or white fibers and nonmedullated or gray fibers, the difference being due to the presence or absence of the white medul- lary sheath. The central and essential part of a nerve fiber is the axis cylinder which, in medul- lated fibers, is surrounded by the medullary sheath or white substance of Schwamm, and the whole enclosed in a delicate membrane called the prirni- n i . m tive sheath or neurolemma, and in nonmedullated fibers is surrounded by a delicate nucleated sheath corresponding with the neurolemma of the medullated fibers. Medullated nerve fibers form the white part of the brain and the spinal cord and the greater part of every cranial and spinal nerve; nonmedullated fibers compose most of the sympathetic nervous system and some of the central. The medullated fibers constitute the white matter of the nervous system; the non- medullated fibers the gray matter. Nerves usually are classed according to the impressions or impulses they conduct and the direction in which the impression or impulse is carried. Afferent nerves conduct impressions of pain, hunger, feeling, etc., from all parts of the body into the central nervous system, and as these impressions are spoken of as sensations, afferent nerves are also known as sensory nerves. Figure 39.—Motor nerve cell. (Howell.) *is the axone; the other branches are den- drites. 74 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Efferent nerves conduct impulses from the brain and spinal cord to the parts to which nerves are distributed. Most efferent nerves go to muscles and are commonly termed motor nerves; those that go to secreting glands are called secretory nerves; while those that restrain or check movement or secretion are called inhibitory nerves. Some nerves have both afferent and efferent fibers and are known as mixed, nerves. The cerebrospinal nervous system. The brain, the largest and most complex mass of nervous tissue in the body, weighs about 3 pounds and fills the cranial cavity of the skull (fig. 40). It is continuous with the spinal cord at the foramen magnum, is very vascular, and when observed in life is seen to pulsate. The outer layer of the brain, the cortex cerebri, is made up of gray matter and the deeper parts of white matter. The gray matter, composed largely of nerve cells, receives and stores affer- ent impressions and transforms them into efferent impulses; the white matter, consisting principally of nerve fibers, conducts the efferent impulses. The brain is covered by three membranous coats, the meninges, which, named from without inward, are the dura mater, the arachnoid, and the pia mater. The dura mater, a dense membrane of fibrous connective tissue, contains many blood vessels and is arranged in two layers, except in a few places. The outer layer of the dura mater is adherent to the inside surfaces of the bones of the skull where it forms their periosteum. The inner layer covers the brain and sends numerous prolongations inward for the support and pro- tection of the lobes of the brain. These projections form the venous sinuses through which the blood is returned from the brain to the large veins of the neck. They also form the sheath for the nerves leaving the cranial cavity. The inner layer continues through the foramen magnum into the spinal canal to there invest the spinal cord. The arachnoid, a delicate serous membrane, lies between the dura mater and the pia mater. Except in the longitudinal fissure of the brain this mem- brane does not dip down into the crevices and depressions of the brain. Between tjie arachnoid and the pia mater is a space called the subarachnoid space, in which is found a certain amount of cerebro-spinal fluid. It also continues into the spinal canal. The pia mater, a delicate membrane of connective tissue containing a net- work of blood and lymph vessels, lies under the arachnoid and extends to all crevices and depressions of the brain. It contains the blood vessels of the brain and supplies blood to all parts of the brain. It frequently is called the nutritive membrane, and continues into the spinal canal. The brain itself is divided into three main parts: The forebrain, containing the cerebral hemispheres and other bodies; the midbrain, a short constricted portion connecting the pons and cerebelhim with the forebrain; and the hind- brain, consisting of the medulla oblongata, pons, and cerebellum (fig. 40). The cerebrum, the largest part of the brain, fills the whole of the upper part of the cavity of the skull. It is composed of gray matter externally, which is the active part of the brain, and white matter internally, in which are em- bedded masses of gray matter. The outer portion of the cerebrum is made up of alternate elevations, called convolutions, and depressions, called fissures. The fissures divide the cerebrum into hemispheres and the hemispheres into lobes, the latter bearing names corresponding to the cranial bones near which they lie. The hemispheres are known as right and left. The great longitudinal fissure extends from the front to the hack of the cerebrum and completely divides it into two hemispheres except in the middle ANATOMY AND PHYSIOLOGY 75 portion where a broad transverse band of white fibers called the corpus cal- losum connects the hemispheres. The transverse fissure separates the cerebrum from the cerebellum. The fissures of the brain divide each hemisphere into sections called lobes, designated as the frontal, parietal, temporal, occipital, and central, or Island of Rcil. Among the important fissures are the fissure of Rolando, called the central sulcus, running from the top and near the middle of each hemisphere downward and forward for two-thirds of its ver- tical measurement and separating the frontal lobe from the parietal lobe; the lateral cerebral fissure (Fissure of Sylvius), separating the frontal and pari- etal lobes from the temporal lobe; and the parieto-occipital fissure separating the parietal from the occipital lobe. The function of the cerebrum is to govern all of the mental activities and coordinate body movements. This section of the brain contains the centers or seats of reason, intelligence, will, memory, and all of the higher emotions and feelings. Certain areas of the brain have a prepond- erance of control over cer- tain functions, although all areas are more or less closely connected by asso- ciation fibers; the frontal lobe is primarily the seat of reasoning or higher psychi- cal thought; that portion just anterior to the central fissure is the motor area; the temporal lobe is the seat of hearing; and the occipital lobe is the seat of vision. The white matter con- sists of fibers which run in three directions, from above downward, from the front backward, and from side to side. They form a connection between the different parts of the brain and con- nect the brain with the spinal cord. Within the brain there are four communicating cavities called ventricles. These are the two lateral ventricles, one situated within each cerebral hemi- sphere, the third- ventricle, lying in the lower middle portion of the brain and communicating on each side with a lateral ventricle, and the fourth ventricle, situated between the pons and the cerebellum, connecting above with the third ventricle and continuous through the medulla with the minute central canal of the spinal cord. The ventricles contain a clear lymph-like fluid, the cerebro- spinal fluid. There are openings between the fourth ventricle and the space between the inner and middle layers of the meninges of the brain, which space is continuous with a similar space between the meninges of the spinal cord that also contains cerebrospinal fluid. The cerebellum, sometimes called the “little brain,” lies in the lower posterior part of the skull, between the occipital lobes of the cerebrum above, and behind the pons and medulla oblongata, with all of which it is connected. It is some- what oval in form and consists of two lateral hemispheres and a central por- Figure 40.—Schema showing the connection of the several parts of the brain. (Gray.) 154294°—39 6 76 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tion called the vermis, or worm, and sometimes the middle lobe. A lai’ge, deep fissure called the horizontal fissure incompletely divides the cerebellum into an upper and a lower portion. Other deep fissures separate the hemispheres into lobes, and numerous, curved fissures, varying in depth and roughly parallel with each other, separate the lobes into layers, or leaves, the edges of which appear as fine ridges. The surface of the cerebellum therefore presents a slightly ridged and laminated, or leaf-like, appearance, instead of a convoluted one like that of the cere- brum. The substance of the cere- bellum is composed of a solid, com- pact mass of white matter in the interior over which is a layer of gray matter, and its principal function is believed to be the regulation and co- ordination of ordinary movements and the maintenance of equilibrium. The pons, or pons Varolii, is a roughly rounded, white mass situ- ated in the midline of the cranial cavity at the base of the brain, in front of the cerebellum, beneath the cerebrum, and continuous with the medulla oblongata below. It is com- posed of a ventral, or anterior por- tion and a dorsal portion, and con- sists chiefly of rope-like bundles of nerve fibers connecting with the mid- brain above and the medulla oblong- ata below, and areas of gray mat- ter. From its surfaces emerge the narrow white bands of nerve fibers that connect the medulla oblongata with the cerebrum and the cerebel- lum, the pons thus acting as the “bridge” which its name signifies. In the gray matter of the pons are located the nuclei from which arise some of the cranial nerves. The medulla ohlogata, or spinal bulb, extends in an almost vertical direction from the lower margin of the pons, above, through the fora- men magnum to the level of the upper border of the first cervical vertebra, or atlas, below, where it is continuous with the spinal cord. Shaped somewhat like a flattened pyramid or cone, it rests in and is supported by a shallow groove in the basilar portion of the occipital bone. It is divided into two lateral halves by two fissures continued ihto it from the spinal cord, the anterior one extending the entire length of the medulla and ending at the upper end, the posterior one ending in the lower half. The lateral halves are further divided longitudinally by grooves, and the surface of the medulla consequently appears convoluted. The Figure 41.—Spinal cord and nerves. (Mason.) ANATOMY AND PHYSIOLOGY 77 upper portion of the posterior surface forms the lower part of the floor of the fourtn ventricle of the brain, and the minute central canal of the spinal cord passes through the lower half of the medulla and there opens out into the lower, tapered end of the fourth ventricle. The medulla is made up largely of a continuation of bundles of nerve fibers from the spinal cord, some of which end in the medulla while others pass on into the cerebellum. Much gray matter also is present in which are located numerous nerve nuclei and the reflex centers for regulating respiration, accelerating heart action, and maintaining vascular tone. In the lower part of the medulla a large part of the nerve fibers decussate (cross to the opposite side) which is the reason why one side of the brain controls nervous activity in the opposite side of the body. The functions of the medulla are largely conduction, reflex action, and automatic action, its function of conduction being especially important as it conducts all impressions passing between the brain and the spinal cord. The spinal cord, or medulla spinalis, is that part of the central nervous system which occupies the upper two-thirds of the vertebral or spinal canal (fig. 41). It is nearly cylindrical in shape, being slightly flattened in front and behind, and extends from the level of the upper border of the atlas to the level of the lower border of the first lumbar vertebra, a distance of about 18 inches in the male. Above it is continuous with the medulla oblongata and below it ends in a cone-shaped extremity, the conus medullaris, from the point of which a slender filament, consisting mainly of fibrous tissue and called the filum terminate, extends downward about 8 inches where it is attached to the periosteum of the coccyx and so anchors the spinal cord. The nerve roots which spring from the lumbar and sacral portions of the spinal cord descend for a considerable distance in the spinal canal as a bunch of long nerve fibers which, from its resemblance to a horse’s tail, is called the cauda equina. The three coats or membranes which cover the brain extend down and cover the spinal cord, and the subarachnoid space between the arachnoid and pia mater is likewise continued and also the cerebro-spinal fluid. Between the dura mater and the vertebral column is a protective covering of fatty tissue which also serves as a protection to the spinal cord. Two fissures, the ventro-median fissure anteriorly and the dorso-median groove posteriorly, almost completely divide the spinal cord, leaving only a narrow bridge of substance connect- ing the two halves. The bridge is called the isthmus of the spinal cord and in it is contained the minute cavity called the central canal which traverses the entire cord and com- municates with the fourth ventricle of the brain. The spinal cord is made up of white matter surround- ing an H-shaped section of gray mat- ter (fig. 42). The anterior parts or horns of this H-shaped substance are short and bulky while the poste- rior ones are long and slender. The white matter is composed of bundles of nerve fibers running lengthwise of the cord, the gray of cell bodies, dendrones, axones, and collateral branches held together by neuroglia. The function of the bundles of nerve fibers is to conduct sensory impressions to and motor impulses from the brain. Figure 42.—Cross section of spinal cord at seventh thoracic vertebra. (U. S. Naval Medical School.) 78 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The peripheral nervous system. The cerebral or cranial nerves, consisting of 12 pairs, originate in the brain and supply certain definite areas of the body. They are of three varieties, sensory, motor, and mixed nerves which contain both sensory and motor nerve fibers. These cranial nerves after leaving the cranium through definite ana- tomical exits split up into branches and are widely distributed. They are numbered from before backward in the order in which they arise from the brain, and are named in accordance with their nature, function, or distribution. Number, Name, Type, Distribution, and Function of the Cranial Nerves Nerve No. Nerve name Type Distribution Function 1 Olfactory Sensory. Upper third of the nasal cavity. Sense of smell. 2 Retina of eye. _ Sight. Movements of eye. 3 Oculomotor Motor.. All eye muscles except superior oblique and external rectus. 4 Trochlear do Superior oblique muscle of eye. Do. 5 Trigeminal Mixed.. Skin of face, eyeball, lacrimal glands, mucous lining of mouth and pharynx, teeth, and tongue, muscles of mas- tication. Taste, mastication, secretion, and touch. 6 Ahducens .. Motor External rectus muscle of eye Movements of eye. 7 Facial _ _do All muscles of expression ct face; also supplies ear and part of neck. Facial expression. 8 Internal ear. Hearing and equilibrium. Glossopharyngeal-.. Mixed.. Tongue and pharynx Taste, movement of pharyngeal muscles and sensation to mucous membrane of phar- ynx. 10 Vagus .. __.do Larynx, trachea, lungs, heart, pharynx, oesophagus, and stomach. Both motor and sensory to lungs and larynx. Cardio- inhibitory. Motor to oeso- phagus and stomach. 11 Certain neck muscles . _ Movements of head. 12 Hypoglossal.- __ __.do Tongue Movements of tongue. The spinal nerves, 31 pairs in number, are named in accordance with the loca- tion of their exit from the spinal canal, there being 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal (fig. 41). Each nerve arises from the spinal cord by two roots, an anterior motor root and a posterior sensory root which contains a ganglion in which are the cell bodies of the sensory neurone. The two roots unite to form a single trunk which emerges from the spinal canal through an intervertebral foramen and immediately divides into an anterior and a posterior branch, each of which contains fibers from both the motor and sensory roots. Thus all of the spinal nerves are mixed nerves, for they carry sensory impressions and motor impulses. The posterior branches of these nerves are distributed to the skin and muscles of the back and trunk; the an- terior branches unite to form the three great plexuses known as the cervical, the brachial, and the lumbosacral, from which the nerve supply to the extremities and other parts of the body is derived. From the cervical plexus arise nerves whose branches supply the skin and muscles of the head, face, neck, upper back parts of the shoulders, and thorax, and certain organs within the thoracic cavity; from the brachial plexus arise nerves that supply the upper extremity among which are the median, ulnar, and radial nerves; and from the lumbo- sacral plexus arise nerves that supply the lower extremities, the chief ones being the sciatic (the largest nerve in the body), the femoral, and the obtura- tor nerves. ANATOMY AND PHYSIOLOGY 79 The sympathetic nervous system. This system, also called the autonomic and vegetative, innervates all the involuntary muscles and the various glands of the body, the striated muscles of the heart, and the skeletal muscles may receive some sympathetic fibers. It consists of two rows of central ganglia situated one on each side of the me- dian line, partly in front and partly at the sides, of the vertebral column and extending from the base of the skull to the coccyx, other ganglia situated in different parts of the body, and a network of small nerve trunks connecting the ganglia and ramifying to various organs. The central ganglia are joined with each other by cords of nerve fibers and each ganglion is connected with the spinal nerve of that region and with the spinal cord. A group or collection of ganglia and nerves supplying organs and structures in the body with nerve influence is called a plexus. Among the many of this system in the body are the cardiac plexus supplying the heart, the epigastric or solar plexus supplying the stomach, the pulmonary plexus, supplying the lungs, and the hypogastric plexus supplying the organs in that region of the body. Through the sympa- thetic system the movements of the viscera are regulated, the caliber of the blood vessels determined, the phenomena of secretion controlled, and the meta- bolic processes of life maintained. The activity of this system does not excite the consciousness and is almost entirely involuntary. Nerve action. The outstanding physiological property of nerve fiber is its conductivity, by which is meant the capacity of the nerve fiber to conduct impulses. For ease in description and study the impulses carried by the afferent nerves have been termed impressions throughout this section, while those carried by the efferent nerves have been termed impulses. A nerve impression may then be said to be the influence or effect on feeling, sense, or consciousness resulting from stimula- tion or excitation, and a nerve impulse the influence or effect on muscular or other tissue that incites it to action. Under normal conditions afferent nerve fibers are stimulated or excited only at their endings, called receptors, in the skin, mucous membranes, sense organs, etc., while efferent nerve fibers are stimulated only through the nerve cells from which they spring. Sensory im- pressions are converted into motor impulses in the nerve cells or nerve centers and the conversion may be totally unconscious as well as involuntary, as the emptying of the gall-bladder during digestion, or there may be consciousness of the act, as the winking of the eyelid when the eye is touched. On reaching the central nervous system sensory impressions may be carried to the brain, there to give rise to a specific sensation in the consciousness, or they may be con- ducted by a direct or a devious path within the central nervous system to a nerve cell or nerve center which converts them into motor impulses and con- ducts them away to incite response in some distant muscle or gland cell. When such a response occurs without intervening consciousness it is called reflex action, the nervous activity involved a reflex, and the path over which the impression and impulse travelled a reflex arc. The reflex is the basis of all functional ac- tivity of the nervous system, and the nervous function necessary for the con- trol of the most intricate movements and activities is probably only a com- pounding of reflexes. In reflex action it is essential that there be: 1. A receptor on which the stimulant or excitant is brought to bear; 2. A path to the central nervous system by which the sensory impression is carried; and 3. A path from the central nervous system by which the motor impulse is carried. Although 80 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the sensory impressions may be sent to and the motor impulse received from the brain in reflex action, it is believed that in most cases the impressions are received in the spinal cord and the motor impulses originated therein. Thus, in response to impressions received over the afferent or sensory nerves, the nerve cells in the spinal cord send out orders without waiting for the impression to be carried to the brain or central nervous system and the orders sent out from there. As an example, the hand is pricked by a tack (fig. 43). The receptor nerve ending receives the sensation and the afferent or sensory nerves carry it to the spinal cord and brain. Before the sensa- tion has reached the brain, however, an order to lift the hand has been originated by the nerve cells in the cord and sent out by the efferent or motor nerves. The hand is moved and the brain made conscious of the prick at about the same time. Reflexes are classed as simple reflexes, in which a single muscle or gland is involved, as in the corneal reflex; complex reflexes in which several muscles or glands are involved, the action remaining per- fectly coordinated, as in the patellar reflexes; spreading reflexes in which a large number of muscles are involved; tonic reflexes or continu- ous reflexes in which a reaction is repeated a number of times as in swallowing, coughing, hiccoughing, etc.; and association or perception reflexes in which a mental picture produces reaction, as in the flow of saliva or gastric juice when well-cooked food is seen or smelled, or when one person yawning causes others to do likewise. The special senses. Various kinds of external stimuli produce nerve impressions which give rise to the phenomenon in consciousness known as sensation. Stimuli within the body give rise to such sensations as thirst, hunger, fatigue, and many other less well-defined sensations. The body is equipped with various mechanisms especially adapted to receive specific forms of stimuli from external surround- ings. These mechanisms are called the organs of the special senses. The skin contains various forms of sensory nerve endings, which, when acted upon by specific stimuli, give rise through the nerve impulses generated to such sen- sations as heat, cold, pressure, and pain. Other more elaborate mechanisms similarly provide for the senses of sight, hearing, smell, and taste. Figure 43.—Diagram of reflex action: a. Tack pricking hand; 6, h', afferent nerves; c, c', c", nerve cells; d, d', efferent nerves; e, muscle moving hand; f, white matter; g, gray matter; h, spinal cord; i, medulla oblongata; k, brain. ANATOMY AYD PHYSIOLOGY 81 The visual apparatus consists of the eyeballs, the optic nerves, and the visual centers in the brain, together with certain associated organs, as the eyelids, eyebrows, muscles of the eyeball, and the lacrimal apparatus. The eyelids are two thin movable folds projecting from above and below, placed in front of the eye. They are covered externally by skin, and internally by a mucous membrane, the conjunctiva. This internal lining, the conjunctiva, is reflected over the front of the eyeball. The interior of the eyelid is com- posed chiefly of connective tissue, part of which is dense fibrous tissue which forms the tarsal cartilage. Several small glands, the Meibomian glands, are situated in this connective tissue. The upper eyelid contains a small muscle which acts to elevate or lower it. On the margin of each lid are double or triple rows of short hairs or cilia called the eyelashes. The function of the eyelids is to afford protection to the eyes. They are movable shades which may exclude light, dust, and other injurious substances. The lacrimal apparatus consists of the lacrimal glands, the canaliculi, the lacrimal sac, and the nasal duct. The lacrimal gland is situated at the up- per and outer angle of the orbit and secretes tears which flow to the surface of the conjunctiva via several small ducts. This secretion passes over the eye- ball and is collected by the canaliculi at the inner angle of the conjunctiva. These canaliculi communicate with the lacrimal sac from which the tears are discharged into the nose through the nasal ducts. The orbits are bony cavities in which the eyeball and its muscles are con- tained. They are shaped like a four-sided pyramid and are made up of seven bones, the zygomatic, maxilla, palate, ethmoid, frontal, sphenoid, and lacrimal. The orbit contains two openings posteriorly, the optic foramen for the passage of the optic nerve and the ophthalmic artery; and the sphenoidal fissure for passage of the ophthalmic veins and of nerves to the muscles of the eye. There are six extrinsic muscles of the eye the function of which is to move the eyeball. These are the internal, external, superior, and inferior recti muscles, and the inferior and superior oblique muscles (fig. 44). The innerva- tion of these muscles has been given under the cranial nerves. The general shape of the eye- ball is spherical, or, more exactly, it “is composed of the segments of two spheres of different sizes, the anterior being the segment of a small sphere forming about one- Figdee 44.—Muscles of the right orbit. (Gray.) Figure 45.—The right eye in horizontal section. (Toldt.) sixth of the eyeball and the posterior being the segment of a much larger sphere and forming about five-sixths of the globe” (fig. 45). The surface of the eyeball is made up of three distinct coats or layers. The outer layer consists of the sclera and the cornea. The sclera or “the white of the eye” is a dense, tough, fibrous 82 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY membrane covering the posterior five-sixths of the eyeball and pierced posteriorly by the optic nerve. In front where the light enters the eye the sclera changes to a transparent membrane having no blood vessels, which covers the remaining sixth of the eyeball and is known as the cornea. The middle layer is composed of the choroid and the iris. The choroid is a thin, vascular, chocolate-colored membrane lining the sclera and containing a network of blood vessels and pierced in the back by the optic nerve. It is folded inward and arranged in radiating folds about the lens of the eye. These folds form the ciliary processes and are well supplied with nerves and blood vessels and the ciliary muscle is contained therein. The iris is a thin, circular, contractile disc directly back of the cornea and suspended in front of the lens but not in contact with it, and perforated near its center by a circu- lar opening called the pupil. It divides the space between the cornea and the lens into anterior and posterior chambers which contain a watery substance called the aqueous humor. The iris is composed of connective tissue, pigment cells, blood vessels, and contains two sets of muscles. One set of muscle fibers contracts the pupil, the other dilates it. The function of the iris is to regu- late the amount of light entering the eye—by contracting, it decreases the amount of light entering, by dilating, it increases it. This is the part that gives the eye its characteristic color. The inner layer of the eye is the retina, which is essentially the expanded fibers of the optic nerve. It is the screen on which the images fall, is most essential to vision, and is a transparent, purplish-colored membrane situated between the inner surface of the choroid and the outer surface of the vitreous body, a transparent jelly-like substance nearly filling the cavity of the eyeball and separated from the retina by the hyaloid membrane. The retina consists of eight layers of cells, the most important of which is the first or external layer, called the “layer of rods and cones,” in which the cells act as end organs to the optic nerve. The crystalline lens is a solid transparent body enclosed in a transparent capsule or membrane and held in place by a ligament. It is situated between the iris in front and the vitreous body behind. The lens is an elastic body which hardens and loses its elasticity with age. It is kept normally tense by the pull of the suspensory ligament on the capsule. When the eye is adjusted for near vision, the ciliary muscle contracts, drawing the choroid forward, relaxing the suspensory ligament and allowing the lens to change its shape. This is called accommodation. Common defects of accommodation are: 1. Hypermetropia, or farsightedness, a condition in which the focal point for near objects is behind the retina. 2. Myopia, or nearsightedness, a condition in which the rays are brought to a focal point before the retina is reached. 3. Presbyopia, a condition similar to hypermetropia, found in old age and due to loss of elasticity of the lens. 4. Astigmatism, a condition in which the curvature of the cornea or lens is defective, causing a dispersion of rays and a blurring of the image. The ear or the organ of hearing is composed of three parts: The external, the middle, and the internal ear (Fig.46). The external ear consists of the auricle and the external auditory canal, which extends from the outside to the eardrum, or tympanic membrane. This membrane separates the external from the middle ear. The middle ear (tympanic cavity) is a small, irregular, air- filled cavity located in the temporal bone. It communicates with the pharynx, by the Eustachian or auditory tube, and also with the mastoid air cells, and ANATOMY AND PHYSIOLOGY 83 is separated from the internal ear by a thin bony plate containing two small openings, one of which is closed by a thin membrane. The other opening, the fenestra ovalis, is the connection between the middle and the internal ear, and is occupied by the base of the stapes, one of the ear ossicles or bones located within the middle ear. These bones form a chain extending from the tympanic membrane to the fenestra ovalis. The internal ear contains the perceptive organ of hearing and consists of a ~bony labyrinth hollowed out of the petrous portion of the temporal bone. This labyrinth is lined with a membrane, contains a fluid called endolymph, and is divided into the vestibule, the semicircular canals, and the cochlea. The semicircular canals and vestibule receive nerve endings from the ves- tibular branch of the auditory nerve and have to do with the sensation of equilibrium. The end organs of hearing are located in the cochlea. Hearing is accomplished by sound waves which strike against the eardrum and are transmitted by the ear ossicles to the endolymph of the internal ear, the movement of which stimulates the end organs of hearing. The center of hearing is in the temporal lobes of the brain. The sense of smell is accomplished by emanations from certain substances coming in contact with special nerve endings of the olfactory nerve which are distributed to the mucous membrane of the upper part of the nasal chambers. Taste is accomplished by certain end organs known as taste buds, which are groups of modified epithelium cells of the tongue around which terminate nerve fibers. The perceptive portions of the tongue are the tip, the borders and the posterior portion of the dorsum. The nerves concerned with the sense of taste are the chorda tympani branch of the facial, the lingual branch of the trigeminal, and the glossopharyngeal. There are four fundamental tastes: salt, sweet, acid, and bitter. The pleasing variations which commonly are called taste are usually combinations of taste and smell. It is necessary for a substance to be in solution to stimulate the nerve endings concerned with taste. Certain special functions and activities. Speech, or the expression of coherent thought is brought about by a com- bination of several acts under control of a certain brain center. The center of speech is considered to be located deep in the left temporal lobe df the brain. The larynx contains folds of mucous membrane called vocal chords, which are controlled by muscles which separate or bring these folds together according to the pitch of tone desired. When air is forced from the lungs past these folds certain sounds are produced, and in conjunction with the movements of the pharynx, tongue, lips, and cheeks articulate speech results. Sleep is a period of more or less unconsciousness, during which most of the higher psychical powers are quiescent, but during which the physiological activities continue. It usually is considered a period of rest, in which the constructive processes exceed the disassimilitory or katabolic changes. Certain changes take place during sleep; respiration is slowed, the pulse slowed, and less blood is sent to the brain and greater amounts to the extremities. The cause and necessity for definite periods of sleep is not thoroughly understood. Heat regulation, or maintenance of constant body temperature is a two- sided process, and consists of controlling the loss of heat as well as the pro- duction of heat. Heat is lost through the excreta, through expired air, by Figueb 46.—Section through right, external, middle, and internal ear. (Howell.) 84 HANDBOOK OF THE HOSPITAL CORPS, V. S. NAVY evaporation of sweat, and by radiation and conduction from the skin. Heat is produced by physiological oxidations within the body. This is effected by muscular exercises and partly by the variety and quantity of food. The preservation or elimination of heat is controlled chiefly by the sympa- thetic nervous system, by nerves to sweat glands and vasomotor nerves. An increase of blood to the skin, increases the loss of heat by radiation. The opposite effect may be produced by vasoconstriction or decrease of blood to the skin. Pever is an abnormal condition of increased temperature, the exact cause of which is unknown. Generally it is considered to be a metabolic disturbance caused by certain toxic substances which act upon a possible heat center in the brain and influence the sympathetic nervous system. References Anatomy.—Gray. Text Book of Anatomy.—Cunningham. Human Anatomy.—Piersol. Elementary Anatomy and Physiology.—Whillis. Textbook of Physiology.—Howell. Zoology for Medical Students.—Kerr. A Textbook of Histology.—Bailey. Textbook of Biochemistry.—Harrow & Sherwin. Practical Bacteriology, Haematology and Animal Parisitology.—Stitt, Clough, and Clough Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. CHAPTER III Page Section 1. Minor surgery and first aid 85 Section 2. Bandages and bandaging 131 Section 3. Splints and appliances 148 Section 4. Emergency dental treatment 165 Section 1.—MINOR SURGERY AND FIRST AID Minor surgery is that part of surgery which includes procedures not endan- gering life. The application of bandages, splints, dressings and sutures, coun- terirritation, cauterization, and similar simple surgical measures are all considered as being within the scope of minor surgery. First aid is the emergency treatment of the sick or injured before regular medical or surgical attention can be given. It should neither supersede nor take the place of proper medical or surgical attention and should consist of furnishing temporary assistance to a sufferer pending the arrival of medical aid. In rendering first aid there are certain things that are to be done in all cases of Injury or illness. After taking charge of the situation the hospital corpsman should: 1. Send for a medical officer or somebody capable of giving the proper treatment. 2. Have somebody keep bystanders far enough away to give room to work without hindrance. 3. Lay the patient on a blanket, or clothing spread out flat, with the head level with the body; do not permit him to sit or stand up. 4. Loosen the patient’s clothing about the neck, chest, and abdomen. 5. Examine the patient to determine the nature of the injury or illness, paying particular attention to evidence of haemorrhage, stoppage of breathing, poisoning, wounds, fractures, dislocations, burns, etc. If necessary, cut or rip clothing to get it away from the injured part. In making the examination look at or feel of the chest to determine whether the patient is breathing, note the color of the face, especially the lips and cheeks, look for bleeding from the nose and ears, deter- mine if he is conscious by asking questions of him, examine the lips and mouth for burns, discoloration, or bloody froth and the tongue for cuts, smell the breath for evidence of alcohol or poisons, and feel for the pulse to determine the character of the circulation. 6. Proceed with first-aid treatment at once, treating serious haemorrhage first, stoppage of breathing next, and other conditions in the order of their seriousness. Remember to keep the patient warm. 7. Note the location of the accident or of the patient; inquire of the patient or bystanders as to what happened; get the time the accident or ill- ness occurred and the names of the patient and witnesses; be pre- pared to receive an ante-mortem statement and be sure to have at least two others hear such statement, it may be the patient’s non- cupative or oral will. 86 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY A hospital corpsman giving first aid should do so with evident display of self- assurance and authority born of knowledge, with decision, calmness, alacrity, and alertness of mind, thereby obtaining the confidence of the patient and of interested bystanders. INFLAMMATION Inflammation may be described as the changes which occur in living tissue when it is injured, providing that the injury is not of such a degree as tends to destroy the structure and vitality of the patient. When tissue is injured, the following changes take place: Engorgement of the blood capillaries in the injured tissue and a seepage through the dilated capillary walls of blood fluids and blood cells, particularly white blood cells (phagocytes). Nature brings about these changes with the object in view of bringing aid of a repara- tive and a nutritive nature to the cells which make up the tissue injured. Inflammation manifests itself by certain local signs and symptoms which are produced by changes in the injured tissue. These symptoms are heat, pain, discoloration, swelling, and disordered function of the part involved. Heat and discoloration are due to the enlargement of the blood capillaries, the swelling to the throwing out of blood fluids and cells into the injured tissues, and the pain to the pressure of pent-up fluids on the nerve ends in the area affected. There may also be constitutional symptoms, as increase of tem- perature and increase of white hlood cells (leucocytosis) which depend in a large measure upon the cause of the inflammation and the absorption into the general circulation of the broken-down products of this inflammation. The causes of inflammation are: Traumatic, such as blows and mechanical irritation; chemical, such as stings of insects, mustard, venom of serpents, ivy poisoning, etc.; thermal, heat and cold; microorganisms, such as staphy- lococcus, streptococcus, etc.; and agencies, such as electricity, X-rays, actinic rays of the sun, etc. The general principles involved In the treatment of inflammation are: 1. To remove the exciting cause; 2. To keep the inflamed part at rest; and 3. To reduce the local blood pressure by elevation of the part. Other agencies employed in the treatment of inflammation are heat and cold, wet dressings, and ointments. Heat acts by softening the tissues and hastening the carrying away of the products of inflammation, thus decreasing the pressure on the nerve ends in the inflamed area* Cold acts by contracting the dilated blood capillaries and thus decreasing tension. Wet dressings and ointments act by softening the tissues and frequently contain some agent lo rid the inflamed area of the specific cause of the inflammation—some micro- organism, for instance. The conditions in which inflammation plays a very important part are: Fractures, dislocations, sprains, strains, wounds, burns, frostbite, and many kinds of infection. Inflammation due to microorganisms or bacteria differs from inflammation due to other causes in that the cause of septic inflammation, or inflammation due to bacteria, is a living organism which multiplies and throws off poisons in increasing quantities until such time as the white blood cells and blood fluids thrown out from the dilated capillaries can overpower it. In the case of aseptic inflammation the cause is other than bacterial. The principal danger in a septic inflammation is that the white blood cells and blood fluids will not be able to overcome the microorganisms which may gain access to the circulation and set up areas of inflammation elsewhere in the body. The term applied in this condition is sepsis. MINOR SURGERY AND FIRST AID 87 Bacteria which cause infection or sepsis are present in myriads on the surface of the body and on every article touched, unless it has been ster- ilized. The skin and mucous membranes protect from infection and sepsis, and it is only when there is a break in these tissues that the bacteria of sepsis gain entrance and start septic inflammation. All bacteria of infection and sepsis do not cause the same degree of inflammation, some causing mild and others very severe inflammation. In the case of some it is easy for blood fluids and white blood cells to limit the inflammation locally, while with others it is difficult for them to do so. An abscess is a localized area of infective inflammation containing live and dead microorganisms, live and dead phagocytes (white blood cells which have been combating the microorganisms), fluids forced out from the blood capil- laries, and the broken-down products of dead tissue cells. The content of an abscess is called pus. The treatment of an abscess is in accordance with the rules for treating other inflammations, but with the added rule that the pus when formed must he evacuated. Abscesses should be incised and drainage instituted, in order to reduce pressure on the tissues, rid the tissues of the irritating products of in- fective inflammation, and lessen the chances of the infecting organism gaining access to the general circulation and causing further trouble. Strict care must be taken not to introduce further infective organisms when the incision is made; that is, an aseptic technique must be employed. The incision must be large enough to allow good drainage. Never squeeze an abscess as this tends to break down Nature’s barrier and to spread the infection. Depending on the severity of the inflammation, more or less of this tissue may die, and this dead tissue is spoken of as slough. When the slough includes the skin or mucous membrane, an ulcer results. A boil, or furuncle, is an abscess in the true skin in which the infecting microorganism generally gains access by way of a sebaceous or a sweat gland, and in which there is a small slough in or beneath the true skin. A boil at the end of the nose or within the nostrils is very dangerous because, as a result of handling, incision, or other trauma, the infection enters the blood and is very easily carried by veins to the large venous channels on each side of the sphenoid bone (the cavernous sinuses) and thence spreads to the brain to form abscesses, or to the meninges to cause meningitis, or into the general circulation to result in septicaemia and possibly death. A carbuncle is a boil or furuncle, in which there are multiple sloughs often coalescing in one beneath the true skin. When the pus from these sloughs finds its way to the surface an opening occurs, hence the numerous foci of pointing (called “coming to a head”). Carbuncles, wherever they are located, are very dangerous, those about the face being especially so on account of the ease with which the infection can be carried to the cavernous sinuses and thence to other parts of the body as explained in the preceding paragraph. A patient suffering from one should be brought immediately under the care of a medical officer. If a furuncle breaks, one opening results; i f a car- buncle breaks, numerous openings result. Diabetes, Bright’s disease, and conditions of lowered resistance brought about by living in impure air, on improper foods, etc., render an individual particularly susceptible to boils. Boils and carbuncles should be treated by first placing the site of the furuncle or carbuncle at rest, and putting the patient to bed is advisable. X-ray therapy is the ideal treatment when the boil or carbuncle is in the indurated state, that is, before it has “come to a head.” If X-ray therapy is not avail- able the treatment should be: 1. Rest and avoidance of trauma; 2. Applica- 88 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tion of heat by hot wet-dressings; 3. Relief of pain (aspirin or codeine may be given); 4. Ample fluid intake and high-caloric diet; 5. When there is definite fluctuation make a small incision to evacuate the pus. When there is a medical officer present and in the absence of X-ray facilities, early, radical, and complete excision is curative. No attempt should ever be made to treat a boil at the end of the nose or within the nostrils as over or faulty treatment may result in death. The best treatment for boils in these areas, except that ordered by a medical officer, is to leave them strictly alone; they may be looked at but not touched or handled. SHOCK Shock is a sudden depression of the vital functions of the body. The ner- vous system, which controls these vital functions, may be likened to a system of electric wiring. If too heavy an electric current is made to traverse the wires in an electric system they are likely to be burned out, or fuses blown. Similarly, if too violent impulses traverse the nerve paths in the body, there may be death from complete nonfunctioning of the nervous system, or there may result a much milder condition in which there is only partial functioning of the same. As the nervous system controls all the vital functions, so in shock they are all more or less affected. Practically any impulse traversing the nerve paths, if severe enough, may cause shock. There is emotional shock, where the impulses originate in the brain; traumatic shock, which results from a severe blow in the solar plexus or testicle, or from crushing or cutting a large nerve trunk, or from some severe injury; and electrical shock resulting from a heavy electric current traversing the nerve paths. One of the main effects of too violent impulses on the nerve track is the loss of nerve control over the blood vessels, resulting in the circulating blood col- lecting in the veins, especially the large veins of the abdomen and depriving the brain and other parts of the body of their normal supply. More or less shock occurs from all injuries. Depending upon the stability of the nervous systems of individuals, what might cause a mild case of shock in one could cause a severe case in another. Symptoms. A person suffering from severe shock lies in a drowsy condition, with the limbs limp, but generally is not totally unconscious. The skin is pale and cold; the temperature is subnormal; the pulse is feeble, fluttering, and rapid, and may be irregular and barely perceptible; the respirations are shallow and sighing; the pupils are generally dilated. Great thirst is frequently an accom- paniment of shock. The sensibility of these patients often is lowered and they do not feel pain as acutely as in a normal condition. Shock may result in immediate death from heart failure, or a condition known as reaction may be established. This state frequently is ushered in by vomiting and is characterized by a gradual return of color to the skin and a rise of body temperature accompanied by an improvement in the heart’s action and fuller and deeper respirations. After reaction is established, it is not unusual for the patient to fall into a sound sleep. In a case of mild shock, there may be nothing more than momentary paleness, weakness, and perhaps some temporary confusion of the thought. Other names applied to conditions of shock are faintness and collapse. Concealed haemorrhage resembles shock very closely, and always must be kept in mind in all cases of severe shock. MINOR SURGERY AND FIRST AID 89 Treatment. The principle underlying the treatment of shock is to bring the blood which has accumulated in the large abdominal veins back into the general circu- lation, to bring the proper blood supply back to the brain where the vital centers are situated and to the surface of the body, and to administer proper stimulation. If the shock is at all severe, a medical officer should be sum- moned immediately, but treatment must be started at once without waiting for his arrival. This may be accomplished by placing the patient in the proper position, applying warmth and administering stimulants. The position in which the shocked person is to be placed is on the back with the head low in order that the blood will tend to run into the brain. A good way to do this is to raise the foot of the bed or bench on which lying. Never raise the head of a shocked person by placing it on a pillow. The application of warmth acts as a stimulant, and also tends to bring the blood to the surface of the body. Warmth should be applied both externally and internally. Externally, warmth is applied by friction and rubbing of legs and arms briskly toward the trunk, by putting the patient on a bed in a warm room, covering with blankets and surrounding with hot-water bags, hot bricks or stones. Care must be taken that the latter are properly covered and not so hot as to burn the patient. Loss of body heat always increases shock; therefore, never remove more clothing than necessary from a shocked person, and when possible spread blankets or coats over him. Be careful, while rubbing, that the patient is not uncovered. Warmth is applied internally by hot drinks such as coffee or hot beef tea in small amounts, given frequently, and hot enemas, such as 2 pints of hot saline solution. Care must be taken not to burn the patient Stimulants used hy mouth are one-half teaspoonful of aromatic spirit of ammonia in one-half glass of hot water, hot coffee, hot tea, hot beef tea, or plain hot water; hypo- dermically, one-thirtieth grain of strychnine, or caffeine and sodium benzoate, 2 to 5 grains; and by inhalation, smelling salts or ordinary water of ammonia. Unconscious persons or those unable to swallow should never be given any thing by mouth. The inhalation method is particularly useful in such cases. The most important treatment in electrical shock is artificial respiration which should be continued at least 4 hours in all cases. Shocked patients who have resumed breathing often later stop breathing, and they should be watched closely for hours after treatment. It must be borne in mind in the treatment of all severe injuries that they are accompanied by more or less shock, and that the treatment of this shock is perhaps just as important as the treatment of the injury itself. HAEMORRHAGE Haemorrhage or bleeding is the escape of blood from the heart or< blood vessels due to a break in their walls. Haemorrhage is spoken of as arterial, venous, and capillary, depending upon whether the escape of blood is from arteries, veins, or capillaries. In arterial haemorrhage the blood is bright red in color, and escapes in jets; in venous haemorrhage there is a rapid flow of dark blood, a welling up, as it were, without any spurting; and in capillary haemorrhage there is a steady oozing of red blood from the entire wounded surface. Nature’s method of arresting haemorrhage is by the clotting of blood, thus forming a plug at the point of bleeding. In the average healthy person, it takes from 3 to 5 minutes for blood to clot. There are, however, some abnormal people whose blood-clotting time is very much lengthened and the 90 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY arrest of haemorrhage in them is very difficult. These people are spoken of as hwmophiliacs or bleeders. The clot of blood which arrests the haemorrhage eventually organizes and permanently plugs the break in the vessel wall if it remains undisturbed. Certain factors favor and hasten the formation of a clot at the point of bleeding, such as the stopping or slowing of the blood stream, at that point, and the obliteration or decrease in size of the opening in the blood vessel where the haemorrhage is occurring. When an artery is cut or torn, the muscular wall contracts, thus decreasing the size of the opening. With the increase in loss of blood, the pressure within the circulatory system becomes lower and lower. When the haemorrhage occurs in a confined space, the pres- sure of exuding blood in the surrounding tissue and on the blood-vessel wall tends to slow the current of blood and close the opening in the blood-vessel wall. Treatment. It is possible to assist Nature in arresting haemorrhage by elevation of the bleeding part, thus decreasing the pressure of blood at the point of haemorrhage with the help of gravity; by keeping the patient at complete rest so that the blood clot at the point of bleeding will not be disturbed and so that the blood pressure at that point will be as low as possible, due to the slow beating of the heart; by the application of heat or cold, which tends to cause the blood-vessel wall to contract; by the use, at the point of haemorrhage, of styptics, medicinal substances which act to hasten blood clotting or cause contraction of blood-ves- sel walls; by the use of pressure to close the bleeding vessel; and by the use of ligation or torsion, also to close the bleeding vessel. Do not give stimulants in treatment of haemorrhage, as they increase the blood pressure and tend to cause the dislodgment of the clot at the bleeding point. Capillary haemorrhage is treated by elevating the part and applying very hot or very cold water, followed by the application of uniform pressure by means of a gauze compress and bandage. In some cases it may be necessary to apply a styptic, such as epinephrine (adrenalin). Epistaxis, or nosebleed, and bleeding from a tooth socket after extraction of the tooth are examples of capillary haemorrhage. In epistaxis, or nosebleed, keep the patient quiet and in a sitting position; remove collar or any constriction about the neck; apply cold or ice to the back of the neck, and instruct the patient to breathe through his mouth and not to blow his nose. The cold application to the back of the neck causes a reflex contraction of the blood vessels of the nose. Styptics, such as a solution of alum or of epinephrine, may be snuffed up the nose. Put a roll of paper under the upper lip, between it and the gum. If bleeding still con- tinues, the nostril must be packed by taking some soft material—cotton, linen, or lint—and gently forcing it well back into the nose. If bleeding continues, the person is probably a haemophiliac, and a medical officer should be sum- moned. In severe bleeding from a tooth socket, pack the cavity tightly with cotton or linen saturated with some styptic, such as epinephrine or alum; then have the jaws closed tightly and apply a Barton or a four-tailed bandage. In venous haemorrhage, elevate the part (so little velocity is there in the venous current that often this procedure alone will stop the bleeding). If bleeding continues, make pressure directly over the wound with a sterile compress. If venous haemorrhage is from an extremity, the limb should be bandaged from toes or fingers up to the bleeding point in addition to pressure over the point. A common location for severe venous haemorrhage is from varicose veins of the legs. In the treatment of arterial haemorrhage prompt and decisive measures are required, particularly in the case of haemorrhage from the large arteries. MINOR SURGERY AND FIRST AID 91 Haemorrhage from the femoral artery may result fatally in a few minutes. The main reliance must be on the more strenuous methods, viz., pressure, liga- tion, and torsion. Ligation is the tying off of an artery with sutures, and torsion consists in twisting the end of the vessel with forceps or an artery clamp for five or six rotations; these two methods should be left to a medical officer ordinarily and should not be undertaken by the first-aid man unless absolutely necessary. This leaves the pressure methods available as the main reliance of the first-aid man. Pressure to control arterial haemorrhage always must be applied at some point between the bleeding point and the heart, preferably at a point where the bleed- ing artery can be compressed against bone. Pressure may be applied by means of the fingers, spoken of as digital pressure, or by means of compresses or by the application of a tourniquet. Digital pressure can serve only for a short time, as the fingers soon become tired. This pressure should be made with the thumbs and should be firm enough to arrest the bleeding; it should be made ever the clothes, as too much time may be lost in removing them. One will know that he is pressing on the right place by feeling the artery beating beneath the thumbs and by the arrest of the bleeding; if the artery cannot be found, make pressure directly over the bleeding point. As pressure with the thumb soon becomes tiresome, an assistant should relieve the first-aid man who should prepare to apply other pressure methods, either tourniquet or com- press. A tourniquet is a constricting band, and there are various kinds. The principle of all tourniquets is a pad over the artery to bring the pres- sure on the artery and take it off the veins, a band around the limb and over the pad, and some means of tightening the band. There are a num- ber of special tourniquets, but as they are not usually at hand, a suitable one must be improvised. An excellent one may be improvised with a rubber bandage, a number of turns being made about the limb and the rolled portion of the bandage then placed under the last turn in such a position as to press directly on the artery. The most common improvised tourniquet is the so-called Spanish windlass, in which arrangement any rounded, smooth, hard object, such as a stone, a cork, or a roller bandage, is used as a compress; for the band, a handkerchief, a suspender, a waistbelt, a bandage, or anything of the sort may oe used. To tighten the band, a stick, bayonet, or scabbard, or something of the kind, is passed under the band and twisted until the bleeding ceases, and the ends are then tied to the limb to prevent the band from becoming untwisted. Pressure t>y means of compresses may be effected as follows: A number of small pieces of gauze or linen, or a tampon, previously rendered sterile or antiseptic, are placed in the wound, one on top of the other, until there are a sufficient number to compress the bleeding vessel; a bandage then is applied firmly to hold them in place and exert the necessary pressure. Sometimes more effective pres- sure can be obtained by employing a compress of gradually increasing size (cone- shaped with apex nearest the vessel). Compresses may be applied in the same manner along the course of the vessel. The dangers in the use of tourniquets and constricting bands for the control of haemorrhage are that if applied tight enough to stop arterial haemorrhage they cause pain and swelling of the limb, and if left long enough may cause gan- grene or death of the part below the constriction. Therefore they should be watched and loosened from time to time, at about half-hour intervals. If on loosening the tourniquet the bleeding starts again, tighten it up; if there is no appearance of bleeding leave the loose tourniquet in place with an attend- ant instructed to tighten it should the bleeding recur. The tourniquet method is the most effective in the majority of cases, but due to the attendant after- 154294°—39 7 92 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY dangers, in all but the most severe haemorrhages of the larger arteries arrest of the bleeding by elevation of the part and the compress method should be tried first. All possible care should be taken not to infect the tissue with dirty applications, but sometimes in tremendous haemorrhages all these precautions have to be laid aside to save the person’s life. In all cases of severe haemor- rhage the measures mentioned are only preliminary to arrival of a surgeon. With great loss of blood the patient suffers severe collapse and must be given treatment for shock, except that stimulants must not be given unless the blood vessel has been safely secured against recurrence of the haemorrhage. After severe haemorrhage tremendous thirst generally is complained of and should be relieved with frequent, small drinks. This may be termed the con- stitutional treatment of haemorrhage. The specific treatment for haemor- rhage from certain parts of the body is described immediately following: Bleeding from the scalp.—Apply pres- sure over wound with compress and bandage. Arterial bleeding from the lips.— Grasp lips between thumb and fingers on each side of wound, as the arteries to the lips come from both sides. Arterial haemorrhage in other parts of the face.—Apply digital pressure on the facial artery against the lower jaw midway between the ear and chin where its pulsation can be felt (fig. 47). Arterial haemorrhage from neck.— Apply digital pressure with the thumb on the carotid artery against the verte- brae. (A tourniquet cannot be used in this location.) (Fig. 47.) Arterial haemorrhage from the arm- pit.—Place a compress in the armpit and bind the arm tightly to the side. If this fails, compress the subclavian artery behind the clavicle (collar bone) between the thumb and first rib, or compress it with a key, the handle of which has been padded (fig. 47). Arterial haemorrhage of arm, forearm, or hand.—Apply digital pressure on the brachial artery on the inner side of the biceps, and then apply a tourniquet a little higher up. In case of arterial haemorrhage of the forearm, a pad may be placed in the bend of the elbow and the forearm forcibly flexed on the arm. In case the haemorrhage is from the palm, either of these two methods may be used, or a large firm compress may be placed in the hand with the fingers very tightly closed over it and bandaged in place (fig. 47). Figure 47.—Skeleton with black and dotted lines showing the course of the arteries and x indicating the pressure points. (Mason.) MINOR SURGERY AND EIRST AID 93 Arterial haemorrhage from the thigh, leg, or foot.—Compress the femoral artery against the head of the femur just below the middle of the groin with both thumbs, then apply a tourniquet to replace the thumbs. In case the haemorrhage is in the leg or foot, another method is to put a pad behind the knee, flex the leg forcibly, and tie it in that position. With arterial haemor- rhage in the foot, in place of these two methods, compression can be made, when the bleeding point is on the dorsal surface, on the anterior tibial artery at the instep; and, when the bleeding is on the plantar surface, on the posterior tibial artery behind the internal malleolus (fig. 47). Haemoptysis is haemorrhage from the lungs. It may result from wounds of the lung but more often is due to disease of these organs. The patient usually is seized by a fit of coughing and spits up bright red, frothy blood. Unfortu- nately, nothing can be done to arrest the haemorrhage quickly. The treatment consists of immediately summoning a medical officer, and in the meantime keeping the patient absolutely quiet, at rest, and giving ice by mouth. Listen over the chest, and where rattling is heard, apply an ice bag. Avoid all stimulants. Haemorrhage from the stomach.—The vomited blood is usually dark in color and may be mixed with food. It always should be remembered that vomited blood does not necessarily indicate haemorrhage from the stomach; blood coming from the back of the nose and throat may have been swallowed, and inquiry should be made to find out if there has been any nosebleed. The blood from pulmonary haemorrhage contains air and is frothy while blood from the stomach is not. The treatment is the same as for haemorrhage from the lungs, except that the ice bag is applied over the upper abdomen. Internal haemorrhage, also called concealed haemorrhage, may occur in any of the cavities and from any of the organs of the body as the result of injuries or disease. It is a condition which may be very difficult to diagnose, as the bleeding cannot be seen. Frequently the only symptoms are those of shock. In such cases summon a medical officer immediately; in the meantime, place the patient flat on his back and keep him absolutely quiet. Opiates are indi- cated in haemorrhage of this nature, their purpose being to produce quietness. Primary haemorrhage occurs immediately on receipt of a wound or injury. After the arrest of primary haemorrhage, a recurrence may occur, caused by dislodgement of the clot, the slipping of a ligature, or from the opening of a blood vessel by separation of a slough. Recurrence of haemorrhage within 24 hours is spoken of as consecutive or intermediate, and recurrence after that time is spoken of as secondary haemorrhage. WOUNDS A wound is defined as the forcible solution of continuity of any of the tissues of the body. The principal kinds of wounds are: Clean or aseptic wounds; infected or septic wounds; and poisoned wounds. A clean or aseptic wound is one to which no germs have gained access; the best example of it being a wound made by the surgeon’s knife. An infected or septic wound is one in which there have been introduced pus-producing organisms (see inflammation), or such organisms as produce tetanus or lockjaw, gas gangrene, or hydro- phobia. A poisoned wound is one in which some nonliving poison, as distin- guished from bacteria or microorganisms, has been introduced by the agent causing the wound; e. g., bites of insects, scorpions, snakes, etc. An incised wound is one made by a sharp cutting instrument, the class of wounds commonly known as cuts. A lacerated wound is the result of the tear- 94 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY ing of the skin and underlying tissues by blunt instruments or machinery and presents ragged edges, which do not retract much, and which, as a rule, consist of masses of torn tissues, frequently with dirt ground into them. A contused wound is one in which the division of tissue is accompanied by more or less severe crushing. A punctured wound is deep and narrow; e. g., stabs are punctured wounds. Crushed wounds are more serious than they first appear, due to the fact that the dead tissues are an excellent culture medium for the growth of microorganisms of infective inflammation, resulting sometimes not only in loss of the part but also in general infection of the body, that is, septicaemia or blood poisoning. The term gunshot wound is applied to any wound inflicted by the missile of a weapon of warfare, such as by rifles, pistols, cannon, etc. When the skin and underlying tissues are divided, blood vessels, generally capillaries, also are divided, and there is more or less bleeding from the cut surfaces of the tissue, a clot forming between the cut surfaces. Young connective-tissue cells and capillary buds grow into this clot from the edges of the wound, replacing the blood elements. These young connective- tissue cells and the young capillaries form what is known as granulation tissue or “proud flesh.” Later the young connective-tissue cells and capillary buds develop into the mature connective tissue, and the epithelium of the skin grows over it from the edges of the wound. When the cut surfaces are so close together that there is very little granulation tissue required to heal the wound, healing is said to be by first intention; when the wound is gaping and considerable granulation tissue is required, healing is said to be by second intention. Pus Infection causes gaping of wounds, therefore in wounds infected with pus bacteria, healing is by second intention. Con- nective tissue filling in a gaping wound forms the so-called “scar.” Unless cut ends of tendons are brought together, the two ends will be so retracted, and there will be so much connective tissue formed between them in the healing of the wound, that the function of the tendon will be lost. Unless the cut ends of a nerve trunk are brought together, the function of that nerve will be lost forever. Nerve fibrils making up a nerve trunk re- generate centrifugally, and if the pathway for this regeneration is blocked by a wall of connective tissue, these fibrils can never reach the part they are supposed to innervate. The local factors preventing and delaying the healing of wounds are: Infection with pus bacteria; the presence in the wound of foreign bodies, such as dirt, bits of clothing, etc.; and a lowered vitality of the edges of the wound due to crushing and tearing of the tissues, etc. General and constitutional factors also prevent and delay healing, among these factors being poor circu- lation of blood, diabetes, Bright’s disease and syphilis. General principles underlying the treatment of wounds. Stop haemorrhage and treat shock; so handle the wound as not to introduce fresh bacteria of infection; remove foreign bodies, such as dirt, bits of cloth- ing, etc., from the wound; if infective bacteria already have been introduced into the wound, take measures to eliminate them or prevent their development. If the wound is an aseptic one, bring the edges together so that it can heal by first intention; if the wound is an infected one, keep the wound open and furnish drainage {see inflammation) ; if the wound is a poisoned one, neutralize the poison in it and prevent its entrance into the general circulation; treat any constitutional condition which may delay or prevent healing. There are two main types of bacteria commonly causing infection in wounds: Aerobic and anaerobic. The former are bacteria that live and multiply in the MINOR SURGERY AND EIRST AID 95 presence of air, while the latter are bacteria that live and multiply in the absence of air. The principal bacteria which cause infective inflammation and septiccemia or blood poisoning are Streptococci, some varieties of which are haemolytic (destroy red blood cells), Staphylococci, and Pseudomonas aeru- ginosa (Bacillus pyocyaneous), frequently called the bacillus of green or blue pus; these are aerobic. There are several anaerobic bacteria which are fre- quently present in wounds. They commonly inhabit the intestinal tracts of man and other animals and are often found in soils which have been fertil- ized with animal manure. Among those occurring in wounds, especially in war wounds, are the Clostridium welchii, commonly termed the “gas bacillus’’ and causing gas gangrene, the Clostridium sporogenes, the Clostridium cedematiens, and the Clostridium histolyticum. The Clostridium tetani, or tetanus bacillus, is common in the faeces of horses and cattle and consequently is found with great frequency in soils fertilized with manure from those animals. It is often associated with Clostridium welchii in wounds and it produces a toxin which is one of the most powerful poisons known, being said to be 20 times as poisonous as dried cobra venom. The filtrable virus causing rabies, often termed hydrophobia (fear of water, and a common symtom of the disease) is nonpathogenic and perhaps anaerobic in character. Inasmuch as the bacteria of pus infection are present everywhere, any wound is likely to be infected with them. However, contused and lacerated wounds are most likely to suffer from infective inflammation, owing to the lowered vitality of the tissues. The bacteria of tetanus or lockjaw and of gas gangrene are found in exceptional numbers in the intestinal contents of herbivorous animals, such as horses and cattle, and, for that reason, wounds inflicted by objects which have been contaminated by manure or by heavily fertilized soil are most liable to have introduced into them the bacteria of these diseases. In badly lacerated wounds and in punctured wounds there is great likelihood of absence of air due to the flapping1 back of the torn tissues after infliction of the wound, and for this reason these types of wounds afford a very favorable environment for the development of tetanus or gas gangrene. Tetanus, or lockjaw, frequently occurs after stepping on a nail near a bam or a stable, the nail previously having become infected with Clostridium tetani from the excretions of horses or cattle. The virus of rabies is found in the saliva of a rabid animal and is introduced by its bite. These bites generally are either lacerated or punctured wounds, with their associated anaerobic conditions. A wound dressing consists of everything used to cover or dress a wound. The pad which is put directly over the wound is called a compress. In ordinary emergency treatment a wound dressing consists of a compress with bandage to hold it on. A dressing may be either dry or wet, aseptic or antiseptic. An aseptic dressing is one which is sterile, that is, one with no bacteria on it. An antiseptic dressing is one which, in addition to being sterile, contains some sub- stance for killing bacteria. A wet dressing generally is an antiseptic dressing. A wet antiseptic dressing generally is used in wounds where infective inflam- mation is going on, whereas a dry sterile dressing is used to cover a fleeent wound which is considered to be free from infection. The purpose of a wound dressing is to stop haemorrhage, to prevent introduction of bacteria, and to prevent further injury to the wound. The Navy supplies a first-aid packet which is a hermetically sealed tin can containing a dry sterile dressing. This is excellent for a small wound. The directions for its use are contained in the packet. For large wounds, sick bays aboard ship are furnished with large and small shell-wound dressings. All these dressings consist of a sterile gauze compress with bandage attached Any 96 HANDBOOK OF THE HOSPITAL CORPS, U, S. NAVY piece of cloth, such as gauze, cotton, linen, muslin, or a handkerchief, is suit- able for a compress in case of emergency, provided it is rendered sterile, and anything that can be used for bandaging is suitable as a bandage. The most vital point about material used as the compress of a wound dressing is that, before it is applied to a wound, it should be rendered sterile. The part of the dressing which is to come in contact with the wound must be kept absolutely sterile; i. e., it must not be touched with any part of the body or anything else except sterile Instruments before its application to the wound. In an emergency, material to be used in a wound dressing may be sterilized by boiling it for 10 minutes. When a patient can be brought under the care of a medical officer in the very near future, the procedure necessary in the first-aid treatment in the case of ordinary wounds is: Stop the haemorrhage, treat the shock, and apply a sterile dressing to the wound. If a surgeon is not available, the wound must be further treated as described hereafter. In treating a freshly made wound suspected of being contaminated (all wounds should be suspected of contamination by infective organisms unless made under strictly aseptic precautions) the following procedure is recommended; Cleanse one’s own hands as thoroughly as possible by a thorough scrubbing with soap and hot water, followed, if possible, by immersion of the hands in hot 1-2,000 bichloride of mercury solution and then in 70 per cent alcohol. Sterilize all in- struments to be used in removing foreign bodies such as dirt, glass, splinters, etc., or for shaving the skin about the wound. If there is much bleeding, arrest the haemorrhage. If there is much hair about the part, remove it by cutting or shaving for a distance of several inches from the cut edges. If there is much grease in and about the wound, remove it with turpentine or gasoline. Remove all foreign particles with sterile forceps. Clean the skin about the wound with a sterile damp cloth, and, while doing this, protect the wound with a piece of sterile gauze. Dry the wound and skin about it with sterile dry cloth or cotton. Apply tincture of iodine to all parts of the wound and to the skin about the wound for a distance of about one-half inch beyond the wound edges. After the skin has been well dried, the wound edges are brought together and a dry wound dressing applied. There is no substance which should be used by the first-aid man to wash a wound. In the first place, he only washes in more dirt than he washes out, and, secondly, ordinary water is dangerous, as it contains many bacteria; this applies equally to soap and water. Strong antiseptics such as bichloride of mercury or phenol (carbolic acid) will destroy the cells of the body which dispose of the pus bacteria before they kill the latter, and should never be used except in certain wounds described later. Peroxide of hydrogen is not strong enough to kill all bacteria, and in a large or deep wound it washes some of these bacteria to un- infected parts which then become infected. Therefore, use none of these prepa- rations in a wound, which should be covered with a sterile cloth, while cleaning the skin around the wound as described before. If, however, there is much greasy dirt rubbed into the wound, the latter should be gently swabbed out with sterile gauze or a cotton applicator, saturated with benzine or gasoline, and for- eign bodies picked out with sterile forceps. Tincture of iodine is the only sub- stance to be used in an ordinary fresh wound by the first-aid man, aside from benzine and gasoline to cut grease, if present. The tincture of iodine should be used within two hours after the wound is inflicted, as after that time it is probably valueless. Tincture of iodine is best applied with a camel’s-hair brush, but a bit of cotton on a stick answers the purpose very well; the brush or cotton need not be sterilized, us the iodine accomplishes this. The tincture MINOR SURGERY AND FIRST AID 97 of iodine may be poured into a wound. Iodine can be used in wounds practi- cally anywhere in tbe body except in or near the eyes, where it must never he used. It must not he used in conjunction with bichloride of mercury. Attempts to bring the wound edges together should not be made when the patient can be brought under the care of a surgeon in the very near future, but if hours or days must elapse before the service of a medical officer can be obtained, coaptation shoidd be done in cases requiring it. The edges of a wound should not be brought together before foreign bodies and dirt have been re- moved and wound edges cleaned. Wounds in which infective inflammation is going on should be left open and allowed to drain. The two methods by which coaptation may be accomplished are by means of sutures and by means of adhe- sive strips. The former is preferable, as by the latter method bacteria of in- fective inflammation most probably will be introduced. As a rule, the edges of large deep wounds should not be too tightly apposed. Some chance of escape should be left for the serum and blood which are sure to be present, that is, means for drainage should be supplied. This may be done by the use of small pieces of sterile rubber tubing, strands of catgut or silkworm gut, or a narrow strip of gauze which has been sterilized by boiling. These drains should be placed in the lower angle of the wound. Wounds which are dirty and look badly should be left wide open. The materials ordinarily used for sutures are plain catgut, chromicized cat- gut, kangaroo tendon, silkworm gut, silk, or linen; sometimes horsehair also is used. Suture material, also called ligatures, is divided into absorbable and nonabsorbable ligatures. Ahsorhahle ligatures are those which can be left in a wound, inasmuch as the tissues absorb them, and included in this class are catgut and kangaroo tendon. Silkworm gut, silk, linen, and horsehair are non- ahsorhahle ligatures and must be removed after 6 or 7 days. Chromicized cat- gut is catgut which has been so treated that it is not as quickly absorbed as plain catgut. Catgut is the ligature to be preferred in the suturing of wounds. Needles used in the suturing of wounds are; Curved, straight, and round, or cutting. Where the skin must be pierced, the curved cutting needle is preferable. The main point about all suture material to be used in a wound is that it must be sterile. In case of emergency, an ordinary sewing needle with cotton or silk thread, well sterlized by boiling, may be used. This suture is nonabsorbable and must be removed after 6 or 7 days. With the operator’s hands, and also the wound, well cleansed, the needle, threaded with the suture, is passed through the skin about one-eighth of an inch from the cut edge and on out through the opposite side at a corresponding point The suture then is tied, and the ends cut leaving about one-quarter of an inch remaining; care should be taken in tying the suture to use but little tension, sufficient only to bring the cut edges in accurate approximation. The remaining stitches are inserted in the same manner at a distance of from one-quarter to one-half of an inch apart until the wound is closed. When a tendon or large nerve has been cut, the ends must be brought together and sutured with catgut be- fore the wound is closed. Suturing of tendons and nerves should be done by medical officers. The manner in which a wound showing evidence of infective inflammation is treated, is: Elevate the part; put it at rest; remove foreign bodies, if pres- ent; remove enough sutures, if present, to obtain good drainage; insert drain; apply a wet antiseptic dressing; and treat the constitutional symptoms. Wet antiseptic dressings generally are made up of a layer of sterile gauze, saturated with an antiseptic solution, to be applied directly on the wound. A layer of sterile cotton is then applied, some impervious material such as oiled 98 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY silk or waxed paper put over the dressing in order to retain the moisture, and a bandage over all. The dressing should he kept wet with the antiseptic solu- tion, either by frequent changing or by having perforated rubber tubes between the gauze and cotton through which the dressing can be periodically moistened with the antiseptic solution. The antiseptic solutions usually employed in wet dressings are: Bichloride of mercury solution 1-5,000; saturated solution of boric acid; and Dakin’s solution. Bichloride of mercury solution should not be applied on a wound freshly painted with tincture of iodine, as a corrosive iodide of mercury is formed which causes a very severe inflammation followed by ulceration. If the symptoms of an infected wound are severe, put the patient to bed, clear out the bowels with a brisk purgative, and apply an ice cap to the head to reduce the fever. The measures taken in fresh wounds suspected of being infected with tetanus or gas gangrene are: The wound is cleaned and treated as has been described, and kept freely open for a time in order that anaerobic conditions may not exist for the growth of these bacteria. As a further precautionary measure, tetanus antitoxin is given. A punctured wound suspected of being infected is frequently cauterized and a dry wound dressing applied. Symptoms and treatment of special types of wounds. Wounds inflicted by an animal suspected of being rahid or of having rabies are to be treated in the following manner: Thoroughly cauterize the wound with filming nitric acid and neutralize with sodium hydrate solution, 1 per cent, or sodium bicarbonate solution, 10 per cent. The Pasteur treatment may be given later. In the absence of fuming nitric acid, a red-hot needle may be used to cauterize the wound. Do not use silver nitrate or phenol for cauterizing these wounds as they coagulate the albumin in the tissues thereby producing the anaerobic conditions necessary for infective organisms and retarding their destruction. Apply a dry wound dressing. Poisoned wounds due to causes other than to bites of poisonous snakes include ordinary insect bites, such as those produced by mosquitoes, fleas, ants and bees. These bites require but little treatment. Sometimes the sting of a bee is broken off and remains in the skin. In treating these cases always search for the sting and remove it if it be present. As the poison of insects is composed chiefly of an acid, the local application of some alkali should be employed; either water of ammonia or a solution of washing soda affords great relief. Bites of the more poisonous spiders, centipedes, tarantulas, and scorpions require prompt treatment. Tie a ligature or tourniquet about the injured part between the wound and the heart to prevent the absorption into the general circulation; enlarge the bite by making an incision at its site, suck out the wound to produce bleeding, and apply crystals of potassium permanganate or tincture of iodine. If there be abrasions or open lesions in the mouth, it is not advisable to suck the wound. Release the tourniquet after a time to permit temporary restoration of circulation, replace it and repeat this process every half hour as long as may be necessary. Apply a wound dressing to the wound and treat shock which sometimes occurs in these cases. Poisonous snakes are classified into viperine snakes and colubrine snakes. To the viperine family belong the rattlesnake, the copperhead, the water moc- casin, and the viper; to the colubrines belong the cobra and the coral snake. In poisonous snakes the teeth are arranged in two rows, with a fang on each side, outside the teeth near the point of the jaw. Nonpoisonous snakes have four rows of teeth without fangs (fig. 48). The imprint of the wound often MINOR SURGERY AND FIRST AID 99 will tell whether a person has been bitten by a poisonous or a nonpoisonous snake. The venom of different poisonous snakes differs in its action. The poisonous constituents are neurotoxin, a nerve poison, and hcemorrhagin, which injures the lining of the blood vessels so that an escape of blood occurs into the surrounding tissues; a third constituent is hcemolysin, which destroys red blood cells. The venom of colubrine snakes is made up principally of neurotoxin and that of viperine snakes of haemorrhagin. In colubrine poisoning, the local symptoms are not marked, though there are at times severe pain and some Figure 48.—1, Single row of scales, posterior to vent (poisonous snake—water moccasin) ; 2, double row of scales of harmless snake (Natrix) ; 3, side view of head of pit viper; 4, side view of head of harmless snake; 5, dorsal view of pit viper; 6, dorsal view of harmless snake; 7 and 9, bite puncture and skull of Elaps; 8 and 10, the same of harmless snake; 11, poison apparatus of rattlesnake. (Stitt.) tenderness, swelling, and discoloration at the site of the bite; then in l1 to 2Vz hours the patient begins to feel tired and drowsy, there often being some nausea and vomiting; paralysis sets in, generally affecting the extremities first and then becoming more generalized, finally affecting respiration, so that the patient’s breathing becomes slow and shallow and finally ceases; convulsions also may be present. In viperine poisoning there is pain at the seat of the bite, which soon becomes excrutiating, with rapid swelling and discoloration; there is at the same time a feeling of nausea and faintness, while a sense of depression takes hold of the individual; the pulse becomes rapid and feeble. 100 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY and the breathing is labored; in fatal cases, death may occur in 24 to 48 hours. The severity of the symptoms and final outcome depend upon the amount of venom injected and absorbed into the general circulation, which in a large measure depends on the size of the snake. The treatment of wounds inflicted by a poisonous snake follows: If the wound is in an extremity, tie a bandage or handkerchief tightly about the single-bone part of the limb between the wound and the heart; incise the wound freely and suck out as much of the poison as possible. If there be abrasions or open lesions in the mouth it is not advisable to suck the wound. With a hypodermic syringe, inject a 2-per cent solution of potassium permanganate into and about the bite to destroy any poison which is left. Meanwhile, give stimulants in the shape of coffee and strychnine, one-thirtieth grain. The ligature should be loosened about every half hour to allow restoration of the circulation, but should be tightened up immediately if symptoms of general poisoning occur. There are antivenin serums available for the treatment of poisoning by snake bite, one which neutralizes neurotoxin and another which neutralizes hsemorrhagin. They are injected hypodermically or intravenously and are very effective if properly used; that is, serum to combat the venom of a colubrine snake must be used against that type of snake bite, and the specific serum for the viperine snake venom used to combat the toxin of that type of snake, in order to get results. Gunshot wounds inflicted by bullets.—Always look for the wounds of entrance and of exit and apply a sterile dressing to each. Concealed haemorrhage and injury to internal organs are the most dangerous results of these wounds and depend on the course taken by the bullet. The wounds of entrance and exit caused by high-velocity bullets may be so small as to be hardly visible, or the wound of entrance may be very small and the wound of exit large, due to the explosive effect of the bullet on the tissues. Never probe a bullet wound, as a bullet is very likely to be sterile, and by probing one is almost sure to introduce germs of infective inflammation. Symptoms and treatment of penetrating wounds of the chest.—The symptoms are the presence of air bubbles in the wound, difficult breathing, coughing, and spitting of blood. The first-aid treatment consists in laying the patient on the injured side, firmly bandaging the chest, summoning medical aid, and the gen- eral treatment for wounds. Symptoms and treatment of wounds of the abdomen with injury to the intes- tines and stomach.—The signs of Injury to the intestines are the escape of gas or faeces through the wound and the passage of blood in the stools. Injury of the stomach may result in the escape of its contents through the wound and the presence of bloody vomitus. Keep the patient absolutely quiet and place under the care of a surgeon as soon as possible, as every moment’s delay in surgical treatment lowers his chance of recovery. With a large abdominal wound from which more or less of the abdominal contents escape, place a sterile cloth over the wound and the extruded intestines; bandage in place and keep the dressing wet with sterile physiological salt solution until the patient can be placed under the care of a surgeon. Treatment for wounds of the eye.—Remove the foreign body, if present, as described under removal of foreign bodies. Never use tincture of iodine or other strong antiseptics in the eye. Boric acid solution or an organic silver prepa- ration (silvol or argyrol) are the only antiseptics to be used in the eye. All eye wounds should be brought under the care of a medical officer as soon as possible. In the meantime cover both eyes with absorbent cotton or soft cloths so as to keep the eyelids still, and hold the dressing in place with bandages MINOR SURGERY AND FIRST AID 101 around the head. Be careful not to put on these bandages so tightly that they will cause pressure on the eyeball. In case some time must elapse before the services of a medical official can be obtained, the dressing should be kept wet with cool saturated solution of boric acid, and if secretions are present, the eye should be irrigated at frequent intervals with warm saturated solution of boric acid. In lifting the eyelid do not press on the lid, but lift the upper lid by traction on the region above it; this prevents scratching of the cornea by pressure. CONTUSIONS, STRAINS, AND SPRAINS A contusion, or as it is commonly termed, a bruise, is a crushing and tear- ing of the tissues, usually without a break in the skin. It is characterized by swelling, tenderness, and discoloration, due to the rupture of blood vessels in the neighborhood of the injury. At first the discoloration is red, then blue or black, and finally turns yellow or green, commonly called black and blue spots. The change in color is due to the chemical change in the coloring matter of the blood haemoglobin. The rapidity in the formation of the swelling and its size depends on the number and size of the blood vessels ruptured. Contusions vary in extent from an ordinary black and blue spot to the almost complete purification of a limb with laceration of blood vessels and nerves such as sometimes occurs in railway or other accidents. A “black eye” is an example of a contusion. Slight contusions as a rule require no treatment. With severe contusions there is more or less shock which must be treated. For the contusion itself, the treatment is to stop the subcutaneous haemorrhage; this can be done by rest and elevation of the part; by very hot or cold applications; and if the injury is in a limb, firm, even pressure of a bandage may be effective. Later, when the bleeding has ceased, the absorption of the extravasated blood may be hastened by hot fomentations and massage. In the case of severe contu- sions and in contusions in elderly people, hot water is much better than cold, as the latter ends to lower the vitality of injured tissue. A strain is the overstretching of a muscle or tendon with an attendant rupture of the muscle or tendon fibers. In severe strains, small blood vessels often are ruptured, resulting in the escape of blood into the muscles in the same way that, in the case of a bruise, blood escapes beneath the skin. It is generally the result of violent exertion or sudden unexpected movement. The symptoms are pain in the affected muscle, stiffness, lameness, and more or less swelling. If complete rupture occurs, there will be loss of power of the affected muscle and on examination there will be found a distinct gap with considerable swelling above it, due to retraction of the muscle fibers. For slight strain, the treatment consists of strapping with adhesive plaster or bandaging, which, with rest, gives the most comfort. After 2 or 3 days, graduated massage may be given. If rupture occurs, in the absence of sur- gical assistance immobilize the part by splints or bandages and place the part in such a position that the muscles are relaxed, thus allowing the torn fibers to come together. A sprain is an injury to a joint due to wrenching or twisting its ligaments and adjacent soft parts. There usually is a momentary dislocation and auto- matic reduction of the joint affected. There also may be injury to cartilages, and even portions of bone to which the ligaments are attached may be torn away. Accompanying these injuries there is more or less escape of blood into the joint itself and surrounding tissues, resulting in severe pain and marked swelling of the injured part. Later, discoloration develops at the site 102 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of injury. sprains of the ankle and wrist are the most common. Frequently it is difficult to determine whether or not a sprain is not complicated with fracture. An X-ray examination is always advisable to determine the presence of a fracture in these cases. In the treatment of sprains all severe cases should he brought under the care of a medical officer, particularly as the condition may be complicated witn fracture. Elevate the joint and apply very hot or very cold water for one-half an hour to an hour to stop the subcutaneous haemorrhage; then apply a tight bandage and keep the joint at rest in order to give the torn ligaments and tissues a chance to heal and the effused blood to be absorbed. Treat- ment of a sprain of the ankle by immediate strapping of the joint and allowing the patient to walk about may be practiced in the less severe uncomplicated cases. For this purpose strips of adhesive plaster 1 to iy2 inches wide and about 18 inches long should be obtained. A strip is started well behind at the junction of the lower and middle third of the leg of the injured side, and is carried down under the heel with considerable tension, across the sole and up the other side of the joint. (Fig. 49.) The middle of another strip is applied to the point of the heel and the two ends are carried forward over the foot, but not far enough to meet. Leg strips and foot strips alternate, inter- lacing with each other and overlapping about one-third of the previous strip each time until the ankle joint is covered. (Fig. 50.) Strapping in this manner furnishes pressure and at the same time fixes the joint and gives support to the torn ligaments. If any individual is unable to walk immediately after injury to the ankle, the injury should be considered as a fracture until proved otherwise. DISLOCATIONS A dislocation is a slipping away from each other of the bones which form a joint, resulting usually in a, locking of the bones in a new position. Neces- sarily the dislocation is attended with tearing of the ligaments, and often with rupture of the muscular attachments as well, except in a joint which, on ac- count of frequent prior dislocations, has had its ligaments so stretched that not only is dislocation easy but no tearing of the ligaments results. As a result of the tearing of structure about the joint, there is also rupturing of the blood vessels, with consequent swelling and discoloration. Dislocations must be differentiated from fractures and sprains. In all three conditions there may be swelling and pain in the neighborhood of a joint. In fracture there is an unnatural movement of the bone between the joints instead of immobility at the joints as in dislocations, and the movement is attended with a grating sound and sensation; the deformity is in the bone be- tween the joints in fractures, whereas the deformity is at the joint in dislocations. In dislocations there is immobility at the joint and between Figure 49.—Strapping of ankle; first step. (Owen.) Figure 50.—Strapping of ankle; completed. (Owen.) MINOR SURGERY AND FIRST AID 103 the joints, and the head of the dislocated bone may be felt in an abnormal position. In sprains there is absence of any of the symptoms of dis- location except swelling and pain. As a rule sprains are momentary dis- locations in which the head of the bone has slipped back into place. All cases, if facilities are available, should be X-rayed before and after treatment. The treatment consists in restoring the bones to their normal positions, spoken of as “reducing the dislocation,” and then so confining the parts that a recur- rence of the trouble will be improbable. The joint should be immobilized until the rents in the ligaments have healed. While some dislocations slip easily back into place, to properly reduce the majority requires considerable knowledge, skill, and either local or general anaesthesia. Without careful manipulation blood vessels and nerves not only may be injured but a simple dislocation may become complicated with fracture. In view of this, if surgical aid can be obtained within a day or two, do not attempt to reduce a dislocation, except perhaps in case of the jaw and finger; loosen the clothing about the injured part and support it as comfortably as possible in the new position, or if the patient must be moved, support the limb in a sling or by splints and bandages, and summon surgical assistance. If, however, surgical assistance cannot be had for some time, 3 or 4 days, careful attempts should be made to reduce the dislocation, as the head of the bones concerned most probably will become bound by connective tissue formation and then reduction will become next to impossible without an operation. Shock is often present with major dislocations and should be treated. Treatment of certain dislocations. Dislocation of the jaw.—In this condition the patient cannot speak or close his jaws. The dislocation is due generally to a blow upon the mouth when open or by yawning or laughing. This dislocation usiially is reduced without much difficulty, but there is great danger of the thumbs of the operator being bitten. Wrap the thumbs well with a handkerchief or bandage, stand in front of the patient, and while pressing with the thumbs in the mouth just back of the last lower molars, at the same time lift up the chin with the fingers. The jaw usually will snap at once into place, and the thumbs must be quickly withdrawn to prevent them from being bitten. After reduction, no fur- ther treatment is indi- cated, but the patient should be advised to open the mouth no oftener than necessary. Dislocation of finger joints.—With a dislocated finger joint, pull on the dislocated end, at the same time bend- ing it backward if the dislocation is forward, or for- ward if the dislocation is backward, and pushing the joint into place; strap or splint the finger (fig. 51). Dislocation of the shoulder.—In this dislocation the arm is held rigid, the elbow stands off a distance of 3 or 4 inches from the body, and the shoulder appears flat with a marked depression beneath the point of the shoul- der. In addition there is pain and swelling at the site of injury, and the head of the humerus can be felt in an abnormal position as compared with the other side. Do not try to reduce this dislocation if surgical assistance can be had in a few days; if not, try one of the three methods following. Figure 51.—Backward disloca- tion of finger ; reduction by extension. (Hamilton.) Figure 52.—Subglenoid dislocation of the shoulder. (Mason.) 104 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY (a) Stimson’s method.-—Place the patient on a canvas cot or stretcher lying on the injured side, arm hanging through a hole made in the cot or stretcher in the median line at a distance of about 18 inches from the head end. The cot or stretcher first should be elevated from the floor by means of chairs or blocks so that the arm does not touch the floor. Fasten a 10-pound weight on the dependent arm, and, in from 5 to 10 minutes, the muscles usually have become sufficiently relaxed to allow the head of the bone to slip into its proper place of its own accord. If it should not do so, the weights should be removed and the arm carefully brought to the patient’s side against the operator’s fist, held in the armpit. This should force the head of the bone back in place. Ap- ply a Velpeau or Desault bandage without the pad in the armpit and keep the arm bandaged for a week. (ft) Kocher’s method.—The patient should be in either the sitting or stand- ing posture, preferably the former. Grasping the affected arm at the elbow and wrist, flex the elbow to a right angle and press the arm against the chest (fig. 53). Turn the forearm as far as possible from the chest by external Figure 53.—Kocher’s method of reduction by manipulation: a. First movement, outward rotation; b, second movement, elevation of the elbow; c, third movement, inward rota- tion and lowering of the elbow. (Ceppi.) (outward) rotation of the humerus. Maintaining this external rotation, carry the elbow slowly inward across the front of the chest to the center line of the body. With the arm in this position quickly rotate the forearm inward until the hand touches the sound shoulder. Lower the elbow. Immobilize the entire arm by the application of a special bandage of the chest or a Velpeau bandage without the axillary pad. (c) Reduction by traction or extension.—Place the patient upon his back on the deck or table. The operator takes off one shoe, inserts his heel under the armpit of the dislocated side, and makes traction upon the arm downward and slightly toward the patient’s body. In doing this, care must be taken not to employ too great leverage action upon the arms, as a fracture might be produced. After reduction, immobilize the joint with a Velpeau or Desault bandage without the pad in the armpit, and keep the arm bandaged for a week. If a dislocation fails to be reduced by these methods, do not persist in attempt- ing reduction, as it is then a case for operative surgery. Dislocation of the elbow, hip, and knee.—These dislocations are not as com- mon as shoulder dislocations. The bones may be displaced in various directions and their reduction is difficult and often dangerous. First-aid treatment con- sists in obtaining surgical assistance, making the patient comfortable with pillows, etc., and treating for shock, if present. Compound dislocations are those in which the head of the bone has been forced through the skin and underlying tissues. Here not only the dislocation MINOR SURGERY AND FIRST AID 105 but also the wound must be treated. A complicated dislocation is one in which a large blood vessel or nerve has been injured. FRACTURES A fracture is the forcible solution of the continuity of a bone. Fractures are classified as simple or closed, and open or compounfi. A simple or closed fracture is one in which there is no opening to the outside air. An open or compound fracture is one in which, by a break in the overlying skin and other tissues, there is direct communication between the outside air and the broken bone. A compound fracture is always very serious, owing to the likelihood of infection. In an infected compound fracture not only is it difficult to obtain union of the bones but there is danger to life from the infection itself. This element of infection is absent in simple fractures. Careless handling of fractures may convert a simple into a compound frac- ture, and there is grave danger of injuring blood vessels, nerves, and other tissues in the neighborhood of the fracture (complicated fracture). Figure 54.—Green-stick fracture. Figure 55.—Comminuted fracture. Figure 56. — Impacted fracture of femur. (Wharton.) A complete fracture is one in which the bone is severed through its entire thickness. An incomplete or green-stick fracture is one in which the bone is broken or bent, but not broken entirely through (fig. 54). (It resembles the condition obtained from an effort to break a green stick.) A multiple fracture is one in which the bone is broken into more than two fragments, the lines of fracture not, however, communicating with each other. A comminuted fracture is one in which the bone is broken into several pieces, the lines of fracture communicating with one another (fig. 55). A complicated fracture is one accompanied by an injury to some surrounding part, as an injury to* a joint, muscle, nerve, or blood vessel. An impacted fracture is one in which one fragment of the bone is driven into the other, the two remaining tightly wedged (fig. 56). When a bone breaks, there is always an injury to the periosteum, or bone covering, and to the surrounding tissues. There is also haemorrhage about the ends of the fragments, and the space between the two fragments rapidly be- comes filled with a blood clot. This blood clot becomes organized as described in the healing of wounds, forming a callus which surrounds the ends of the 106 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY fragments, and, as it were, glues them together. At first the callus consists only of fibrous tissue, but later there is growth of bone cells, and a deposit of lime salts which changes the callus into dense bone. The following factors may prevent the union of fractures; Infection pre- venting the formation of a callus; the interposition between the fragments of muscle or other tissue; improper reduction of the fracture; general constitu- tional conditions such as syphilis, tuberculosis, diabetes, Bright’s disease, and an inability on the part of the patient’s body to deposit bone in the callus. This latter condition in which fibrous tissue, but not bone, is deposited in the callus is spoken of as ‘“fibrous union.” In the diagnosis of fracture the following conditions usually will be found: 1. There is a loss of power in the part, for example, if the leg is broken, the man has fallen and cannot arise; 2. The part is in unnatural position, and comparison of a fractured limb with the uninjured one will show that there is a deformity between the joints and that the injured limb is probably shorter; 3. Movement can be obtained where normally there is no motion, with grating of the broken.ends of the bone (if an attempt to move the limb is made it will be found that there is movement in the bone between the joints where there should be none, and the broken ends of the bone grating together (crepitus) can be felt and heard) ; 4. There is history of violence and the patient will say that he heard the bone crack and, give way; and 5. The patient complains of great pain and tenderness at the seat of fracture and there is swelling present, due to bleeding from the broken ends. Whenever a fracture is suspected or doubtful, an X-ray picture of the part should be obtained, as this is the surest means of determining fracture. General principles for the treatment of simple fractures. The patient should be brought under the care of a medical officer as soon as possible. The object of treatment before a medical officer can take charge of the case, if his services cannot be had promptly, is to prevent further in- jury, especially to blood vessels and nerves, and, puncture of the skin by the sharp, knife-like edges of the broken bone, and to treat shock if it is present. The patient should be placed in a comfortable position while waiting for the medical officer or surgeon, and if it is necessary to move the fractured part in doing this or in treating shock, one hand should support the broken bone on each side of the break. The bone must not bend at the break while the patient changes his position to a more comfortable one. Support the broken bone in a natural position on a pillow or folded coat, great care being taken that it is not bent or does not drag on the point of fracture. If there is doubt as to whether or not a fracture is present, do not manipulate the part, but treat it as a fracture until the arrival of a surgeon. Do not move the patient more than is necessary before the fracture has been set and secured. If the injured person is wearing thin summer clothing, it will not always be necessary to re- move it; if thick clothing is worn, however, it is difficult to determine whether or not a fracture has occurred or the character of the injury. In the latter case, never try to take off the clothing, but cut it in the seams with a sharp knife or scissors. If the patient cannot be brought under the care of a surgeon for a day or more, the fracture must be set and immobilized as described hereafter. If a fracture is not set, it will unite in bad position and the bone will have to be refractured to secure proper 'alinernent. In the treatment of compound fractures the services of a medical officer should be obtained as soon as possible. In the meantime, treat the shock and the wound as described in the section on wounds. After treatment of the MINOR SURGERY AND FIRST AID 107 wound, treat the fracture as described before. In case no surgeon is available for a day or more, the fracture may be set as described hereafter, always keeping in mind the proper treatment of the wound while so doing, thus pre- ATenting, as far as possible, infection which is a serious complication in fractures. The setting of a fracture consists of bringing the two fragments in apposition and in holding them in that position. The force which keeps the fragments out of apposition and which must be overcome in order to bring them into appo- sition is muscular contraction. This muscular contraction is overcome by exten- sion and counterextension. Extension is pulling the far or distal end of the limb, and counterextension is merely holding the near or proximal end next the trunk. Extension and counterextension must be applied until the deformity and shortening disappear and the two limbs look alike. Where the muscular contraction is great, as in fractures of the thigh, the fragments frequently can- not be brought into apposition without relaxation of the muscles by a general anaesthetic or by gradual tiring out of the muscles by a steady pull with weights and pulley. In these cases extension and counterextension frequently have to be applied for some time after the fracture has been set in order to maintain the fragments in apposition. The fragments of a fractured bone are held in apposition by means of splints, plaster of Paris bandages, ordinary bandages, etc. Splints are agents for immobilizing a fractured part. There are two general classifications of splints, traction splints, and coaptation splints. Traction splints are those which, in addition to immobilizing a fracture, are constructed in such a manner that by their use extension and counterextension can be ap- plied without the use of other apparatus for this purpose. Coaptation splints are those which are used solely to immobilize the fracture. Traction splints are indicated in fractures where there is much muscle pull tending to displace the fragments. The most common traction splints are: The Thomas leg splint and modifications of the same, the Jones humerus traction splint, the Army hinged half-ring thigh and leg splint {Keller), the wire ladder splint, and the Cabot posterior vnre splint. To obtain extension by use of these splints, adhesive strips or tapes are fastened to the skin and attached to the distal end of the splint, while counterextension is obtained by the push of the other end of the splint against the body. In emergency any material which has sufficient firmness to give support to a limb will answer for coaptation splints. Examples are umbrellas, canes, swords, scabbards, guns, cigar boxes, wire, leather, laths, tent pins, pillows, or a folded coat. In fractures of the thigh and leg, the sound limb may be used as a splint. Plaster of Paris bandage may be used. Adhesive plaster generally is used to splint a fractured rib. The materials used for splints must be light but sufficiently rigid to prevent bending; long enough to fix into the joints above and below the fracture; broad enough to prevent pinching of the limb in bandaging; and sufficiently padded to protect the part from undue pressure. Coaptation splints may be applied temporarily over the clothing and should always be well padded, as a hard board against an injured limb soon becomes very painful. Oakum, cotton, grass, moss, portions of clothing, or any soft material will answer for the padding. If possible, two splints should be applied to a limb, while in fractures of the leg three generally are used, one on each side and one behind. In applying splints, have an assistant hold them in position and then firmly fasten them to the limb by several turns of a roller bandage, adhesive strips, handkerchiefs, pieces of rope, or portions of clothing. While splints should be applied snugly, care should be taken 154294°—39 8 108 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY not to apply them too tightly for fear of cutting off the blood circulation; leave the tips of the fingers and toes exposed and watch the circulation. If the tips of the fingers are blue and cold, or if, upon pressing upon the nails, the normal pink color does not quickly return, the dressing is too tight. Remember that although a splint may be applied with the proper degree of snugness, later swelling of the fractured limb may cause it to be too tight. The use of plaster of Paris as splinting material should be left to the surgeon. Fractures of the skull are classified as fractures of the vault and fractures of the base of the skull. Fractures of the skull are dangerous on account of the probability of injury to the brain. In fractures of the vault, the danger lies in tearing of the brain tissue itself by the fragments of bone, and in tearing of the blood-vessel walls, resulting in haemorrhage, with the result- ing compression of the brain. Compression of the brain also may result from the displaced fragments of broken bone. In fractures of the base of the skull, the principal dangers are rupture of the meningeal arteries, result- ing in intracranial haemorrhage and compression of the brain. Both types of fracture may be compound, while there is the added danger of infection which, in fractures of the vault, occurs through injury to the overlying tissue at the site of fracture and, in fractures of the base, to infection from the nose and ears due to a tearing of the mucous membrane of the nose and middle ear. In fractures of the skull, unless compound or depressed, all the usual symp- toms of fracture are absent, or entirely overshadowed by the injury to the brain. The most prominent brain symptoms are loss of consciousness and paralysis; if the loss of consciousness is sudden, it is probably due to con- cussion or to the pressure of a piece of bone; if it comes on slowly, it is apt to be the result of haemorrhage from a torn blood vessel. In fracture of the base of the skull, there may be bleeding from the nose or ears, or into the orbits, or under the conjunctiva; the escape of cerebrospinal fluid—a clear, watery serum—from the ears is considered a sure sign of fracture of the base. In the treatment of a fracture of the skull obtain the services of a medical officer as soon as possible. In the meantime, keep the patient quiet, in a re- cumbent position, and apply an ice bag to the head; if the fracture is compound treat the wound. Avoid stimulants. In fractures of the spine the spinal cord is generally injured or cut across, with resulting paralysis to all parts below the fracture. On passing the fingers down the spine, irregularity of the spinous processes with deformity will usually be noted, as well as local pain over site of fracture. Keep the patient perfectly quiet, and lying flat on his face until surgical aid can be obtained. If it is necessary to move him, it should be done with extreme care to prevent any additional injury to the spinal cord, and keeping him in a prone position, face down. Symptoms and treatment for a fractured nose.—There is usually considerable deformity, the bridge of the nose being depressed and pushed to one side, crepitus generally can be felt, and there is considerable nosebleed. Return the bones to their normal position if possible, by gentle manipulation. To hold the bones in position, apply two very small rolls of narrow bandage on either side of the nose and hold the rolls in place with short strips of adhesive plaster. Check the bleeding by syringing the nostril with hot or cold water, or, if necessary, pack the nostrils with cotton. Warn the patient not to blow his nose. Symptoms and treatment of fracture of the lower jaw.—In fracture of the lower jaw the line of teeth is irregular and there may be bleeding from the mouth.; the patient cannot open his mouth, and by passing the fingers along MINOR SURGERY AND FIRST AID 109 the line of the lower jaw localized pain and deformity can be noted (fig. 57). Push the bones into place and apply a four-tailed or Barton bandage. The patient must be fed through a tube and the mouth kept clean, as these frac- tures are generally compound. Place the patient under the care of a surgeon as soon as possible. Symptoms and treatment of fracture of the rib.—The symptoms are pain or “stitch” in the side, and some difficulty in breathing. Pain may be especially severe if the patient coughs or sneezes, or breathes deeply. The danger in rib fracture is injury to the lung, and with this complication there may be spitting up of blood and escape of air beneath the tissues of the chest wall, a condition called emphysema. On examination, by passing the fingers along each rib in successipn, one will be able to find a local point of tenderness, and often a false point of motion or grating in one or more of them. By placing the ear against the injured side and asking the patient to take a deep breath, grating may be heard distinctly. As it is impossible to Figure 57.—Fracture of lower jaw, show- ing loss of alignment of teeth. (Scudder, modified.) Figure 58.—Application of the first adhesive strap in fracture of rib (note elevation of arm and shoulder and application of strap from below upward). splint only one or two ribs, in order to immobilize the fracture it is necessary to immobilize the whole side on which the fracture has occurred. This splinting can be temporarily accomplished with a broad binder of muslin, a triangular HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY bandage, or an ordinary roller bandage applied firmly around tbe cbest, but the best method is to strap the chest with adhesive plaster. Procure a strip of plaster wide enough to cover the injured side, about 8 or 9 inches wide, and long enough to extend from the spine behind to just beyond the median line in front, and apply as follows: With the patient standing with arms above the head, tell him to let all his breath out, and as he does this quickly apply the plaster to the injured side, starting just a little to the other Figure 59.—Strapping of chest for fracture of rib ; completed. side of the spine in the back and bring the strap to just beyond the middle line in front. The plaster is applied at the end of a forced expiration because at this time the broken fragments are more nearly in apposition. In place of a single strip of plaster several strips, each about 2% inches wide, may be applied, beginning well below the fracture and gradually working up (figs. 58 and 59). Apply each strip with firmness, at the end of a forced expiration, allowing it to overlap one-third of the one below. When there is injury to the lungs accompanied by spitting up of blood, keep the patient quiet in bed and give cracked ice by mouth. MINOR SURGERY AND FIRST AID 111 Symptoms and treatment of fracture of the clavicle or collar hone.—In fracture of the clavicle the attitude of the patient is characteristic; the shoulder drops downward, inward, and forward, and he attempts to support it by holding the elbow of the injured side in the hand of the sound side. The collar bone lying immediately under the skin, the fracture is easily made out from the deformity and localized pain and tenderness. As an emergency dressing until the patient comes under the care of a surgeon, all that is required is a large arm sling with a pad in the armpit and the arm bound to the side. Later treatment, in the absence of a surgeon, consists in the application of any dressing which will keep the shoulder up, back, and outward, thereby holding the fragments in their normal position. This may be done by means of the Velpeau or Desault bandages or the Sayre dressing (see section on Bandages and Bandaging) or by the T-splint (see section on Splints and Appliances). Symptoms and treatment of fracture of the humerus or arm bone.—Fracture of the humerus has all the general signs and symptoms of fracture. A fracture of the neck or upper third of the bone may be put up temporarily by placing a pad or folded towel in the armpit and securing the arm to the side with a bandage; then place a sling about the wrist. With this dressing the weight of the arm and forearm acts as an extension. Fracture in the middle of the shaft of the bone may be treated by the use of two broad splints or, better, four narrow ones, placed about the seat of injury and secured by a bandage or strips of adhesive plaster, the wrist being supported by a sling. Care must be taken that the splint does not extend too high in the armpit, as thus it might compress the blood vessels or at least be exceedingly painful. A fracture near the elbow joint may be dressed temporarily by simply applying a large arm sling and securing the arm to the body. Fractures in this locality are serious from the liability of the joint to become stiff, and the patient should be brought under the cax*e of a surgeon as soon as possible. Symptoms and treatment of fracture of the bones of the forearm.—When both bones of the forearm are fractured all the usual signs of fracture are present. When only one bone is broken, the other acts as a splint and but little deformity will be apparent, but there is inabilty to use the forearm, and on examination, tenderness and a false point of motion can be discovered at the seat of injury. With a fracture of the radius alone, low down and just above the wrist, there is a well- marked deformity, termed silver-fork deformity (fig. 60), which is a symptom of the fracture of the radius spoken of as Colics' fracture. In this frac- ture the tip (styloid process) of the lower end of the ulna Is often broken off, there may be rupture of the internal lateral ligament of the wrist, and as the bones are usually impacted, no grating or crepitus is present. In treating fractures of the forearm, the limb should be put up with the elbow bent at a right angle, the forearm across the chest, with the palm of the hand turned in and thumb pointing upward. First reduce the deformity by gentle traction upon the hand, and then apply two well-padded splints to the seat of fracture, having them long enough to extend from the elbow to below the wrist; bandage the splints, and support the forearm by means of a sling. It is very important that all cases of Colles’ fracture should be brought under the care of a surgeon as soon as possible, as, unless the fracture is prop- erly reduced and treated, the deformity is apt to be permanent. Figure 60.—Deformity at the wrist consequent upon dis- placement backward of the lower fragment of the radius after fracture at its lower extremity. (Levis.) 112 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Symptoms and treatment of fracture of the metacarpals, or wrist bones.—De- formity and pain are the most prominent symptoms. Apply splints on the back and front of the hand, reaching from the finger tips halfway up the forearm. Treatment of fractured fingers.—If only one finger is fractured, a narrow splint, such as a wooden tongue depressor (fig. 61), should be applied to the palmar surface of the finger and secured by strips of adhesive plaster. If sev- eral fingers are broken, it is better to place a pad in the palm of the hand and apply two well-padded splints, extending from below the tips of the fingers well up on the forearm. Figure 61.—Tongue depressor as a splint for fracture of finger. Symptoms and treatment of fractures of the pelvis.—The patient is unable to sit up or stand and complains of great pain and a sense of coming apart. Crep- itus may be felt on strong pressure. These fractures generally are accompanied with injury to internal organs and more or less shock. With injury to the bladder blood is passed in the urine. When fracture of the pelvis is suspected have the patient lie quietly on his back, apply a tight binder or bandage to the hips, and also fasten the knees together. He should be moved with great care and transported on a stretcher which will not sag. The patient’s bed should be fixed so that it will not sag under his pelvis and the thighs should be supported with pillows. In case of bleeding from the bladder, which indi- cates a rupture of that organ, a catheter should be introduced and left in, so that the urine will not accumulate and escape into the peritoneal cavity. A urinary antiseptic (methenamine (urotropin)) should be administered by mouth. Symptoms and treatment of fractures of the femur or thigh.—The patient usually lies with the toes of the injured limb pointing outward; any attempt to move the limb results in a spasm of the muscles and causes the patient ex- cruciating pain; there is loss of power in the limb, the patient being unable to lift it. Ou examination, if the fracture is on the shaft of the bone, a false point MINOR SURGERY AND FIRST AID 113 of motion is discovered. By measurements the fractured limb is found to be shorter than the other one, due to the pull of the powerful thigh muscles. Measurement should be made on each limb and compared by stretching a string from the anterior superior spine of the ilium to the internal malleolus with the patient on his back. Emergency treatment consists in applying two splints, one on the outside reaching from the armpit to beyond the foot and one on the inside from the crotch to the foot (fig. 62). The splints should be tied in five places—around the ankle, over the knee, just below the hip, around the pelvis, and just below the axilla. It is well also to tie the two limbs together. The Figure 62.—Service rifle as emergency splint for fracture of femur. patient must be brought under the care of a surgeon as soon as possible, as an amesthetic is frequently necessary to effect reduction, and a traction splint or other means of extension is generally required. Do not move these cases with- out splinting. \ Symptoms and treatment of fracture of the patella or knee cap.—In a frac- ture of the patella the patient cannot stand or walk, the upper fragment is drawn up to the thigh by the powerful muscle attached to it, and the gap can be felt readily; the joint swells up at once. Put the limb up straight with a well padded splint behind the thigh and leg. The two fragments can be brought together by strips of adhesive plaster, one strip passing above the upper frag- ment and the other below the lower one, or in place of the adhesive plaster a figure-of-eight bandage may be applied. The patient should be put to bed with the injured leg elevated on a pillow, and ice should be applied to the joint with the object of limiting and decreasing the swelling. Place the patient under the care of a surgeon as soon as possible. Symptoms and treatment of fracture of the leg.—When both bones of the leg are broken, the usual signs and symptoms of fracture are present. These 114 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY fractures often are compound. If only one bone is broken, the other acts as a splint and deformity will not be so marked, but there will be present a local point of tenderness, swelling, and probably discoloration of the skin. Fracture of the lower end of the fibula is spoken of as Pott’s fracture (fig. 63). Pott’s fracture generally is accompanied by tearing of the internal lateral ligaments of the ankle joint or by a fracture of the internal malleolus, in which case there is great deformity and turning out (eversion) of the foot. In case it is purely a fracture of the lower end of the fibula, there may be few of the usual signs of fracture and the in- jury may be mistaken for a sprain. For treatment of fractures of the leg, reduce any deformity by traction in the long axis of the limb, and then apply three well-padded splints, two side splints, and a posterior one (in case of Pott’s fracture, do not apply a posterior splint). The latter is to give support and prevent a backward sagging at the seat of fracture. A pillow and two side splints also make an excellent temporary dressing; a pil- low covered by a pillow case is placed upon the deck, and the injured leg is laid carefully upon it; the edges of the pillow then are brought un around the foot and limb and are pinned in place; finally the two side splints are applied outside of the pillow and are secured in place by straps of adhesive plaster or strips of bandage. Treatment for fracture of the foot.—Apply a light splint to the sole of the foot, and keep it immobilized by two side splints extending up each side of the leg from below the foot. Place the patient under a surgeon’s care, so that a plaster of Paris bandage may be applied. INJURIES DUE TO HEAT AND COLD Injuries due to heat are classified as general which embraces heat cramps, heat stroke (or sunstroke), and heat exhaustion, and local which includes burns and scalds. Heat cramps are painful, spasmodic contractions of the muscles, usually those of the abdomen or of the extremities, and are caused by exposure to heat and to conditions causing muscular fatigue and loss of body fluids and salts. They may be considered the mildest form of generalized body injury from heat and their treatment is essentially the same as that for heat exhaustion. Heat stroke (sunstroke or insolation) is due to prolonged exposure to exces- sive heat, usually to the heat of the sun. It may, however, occur in not rooms, particularly in firerooms aboard ship. Exhaustion and improper clothing pre- venting the proper elimination of heat from the body surface are powerful con- tributing factors; hence this condition is especially apt to occur to men on the march, particularly when marching in close formation. The warning symptoms are headache, dizziness, irritability, frequent desire to urinate, and seeing things red or purplish. With or without these symptoms, the patient sud- denly falls unconscious; the skin is dry and intensely hot; pupils contracted; pulse full and strong; respirations snoring; there may be convulsions; if the temperature of the body can be taken it usually will be found to be very high, Figure 63.—Pott’s fracture. MINOR SURGERY AND FIRST AID 115 105° to 109° F., or higher. The condition is very serious, and unless immedi- ately relieved terminates in death. The treatment has for its object the rapid reduction in temperature. The patient should be brought to the coolest acces- sible spot, in the shade, if out of doors; on deck if in the fireroom of a ship; the clothing removed; an ice bag applied to the head and cold water poured over the patient continually. At the same time the body may be rubbed with ice, and if a tub is available, immersed in cold water. The treatment should continue until the temperature is reduced. If the patient is able to swallow, cold, not iced, water should be given to drink, and this should be repeated as often as possible. Besides these measures for reducing the body temperature cool water to which table salt has been added, one-half teaspoonful to the glassful, should be given as freely as the patient will take it. In very severe cases, with the patient unconscious and unable to take fluid by mouth, give copious and frequent enemeta of 1,000 to cc of cool, salt water, 1 tea- spoonful of table salt per pint of water, every 30 minutes or hourly depending on the patient’s response in recovering consciousness and on the drop in his body temperature. Serious results are liable to follow a sunstroke, even when death does not occur; the most common of these after effects are permanent headache, paralysis, mental confusion, or even insanity. Moreover, one who has had a sunstroke is ever after very susceptible to the action of the sun. Heat exhaustion is due to the same causes that produce heat cramps and heat stroke. Under the same conditions, one man may get heat cramps, another heat stroke, and still another heat exhaustion. The warning symptoms are dizziness, often with nausea and vomiting associated in some instances, par- ticularly in flrerooms aboard ship, with cramps in the muscles. The patient suddenly falls; is not unconscious and may be easily aroused; temperature is subnormal; the face is pale, skin cool and moist; pupils dilated or normal; pulse very weak; respirations shallow, perhaps sighing; and perhaps one or several sets of muscles in painful contraction. In this condition of heat exhaustion certain muscles or groups of muscles frequently are thrown into violent con- tractions which cause excruciating pain. This condition is relieved by hot applications, immersion of the part of the person’s body in a hot bath, or by the administration of an opiate (hypodermic injection of morphine). The treatment for heat exhaustion consists in moving the patient into the shade or on deck, loosening the clothing, keeping the head low, and giving him salt and stimulants; hot salt water or coffee to which one-half teaspoonful of table salt to each cupful or glassful has been added should be given freely. After removal to the sick-bay or hospital, the patient should be kept perfectly quiet in bed, with hot-water bottles and blankets around him if necessary. The prophylaxis or prevention of heat cramps, heat stroke, and heat ex- haustion is most important. It is now known that most of these general reactions to the effects of heat are due in great measure to the loss of body salts, chiefly sodium chloride, in the perspiration or sweat. A person per- spiring freely for some time will not so readily taste salt in his drinking water which shows the loss of it in his body. Persons working in compart- ments in high temperatures, such as engine rooms and flrerooms, especially in the tropics, should replace lost salt by taking ordinary table salt by mouth. One Navy sodium chloride tablet per glassful of water may be used, but in the absence of these tablets ordinary table salt should be taken freely under conditions where heat cramps, heat stroke, and heat exhaustion are likely to occur. The number of cases of heat cramps, heat stroke, and heat ex- haustion can be reduced to a minimum by the adequate prophylactic use of sodium chloride in the drinking water. 116 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Burns and scalds.—Burns are produced by flame, hot solids, hot fluids, caustics such as strong acids and strong alkalies, wires charged with a heavy electric current, sun’s rays, and X-rays; scalds are produced by hot liquids. Burns and scalds differ only in that in the former the hairs are removed, whereas in the latter they are not; the treatment is the same for both. Burns usually are said to be of the first, second, and third degree; those which cause merely redness are of the first degree; if blisters are raised, they are of the second degree; if there is charring and destruction of tissue, the burn is of the third degree. The symptoms of burns are shock, which may be profound, chilly sensations, and pain; the pain may be agonizing or slight. The result of the burn depends more upon the extent of surface affected than upon its depth, a burn of the first degree being almost fatal if two thirds of the body surface be affected, and one of the second degree if one third of the body is burned. The chances of recovery are much less in children and elderly people. With extensive burns of the body surface, the danger in the first 24 hours is from shock, after that from internal congestion and inflam- mation, suppression of urine from nonfunctioning of the kidneys, ulcerations of the duodenum, intestinal haemorrhage, and finally exhaustion or infection. If the entire thickness of the skin is destroyed, terrible deformities are apt to follow the contraction of the skin which follows healing. As the result of inhalation of live steam from bursted steam pipes, the respiratory tract may suffer from burns, causing death in many instances from suffocation or shock. X-ray burns are particularly slow in healing. The treatment of burns is both constitutional and local. The constitutional treatment consists in the treatment of shock and pain, on the one hand, and, on the other hand, in measures to prevent suppression of urine, in combating the toxaemia and the effects of infection, etc. In addition to local measures for the treatment of pain, the administration of morphine, one-fourth grain, hypodermically, is frequently necessary. The bowels must be kept open, and plenty of water given by mouth, and also at times by rectum, so that the kidneys will continue to act. The smaller the area of body surface burned the less necessity there is for constitutional treatment. The object of the local treatment is to remove the cause, to allay pain, prevent infection, and promote healing. The deeper the burn, the more important do the methods for the prevention of infection become, and vice versa. The greatest factor in the causation of pain in burns is the movement of air over the inflamed area, and therefore local treatment in first-degree burns consists of covering the burned surface so that air is excluded. This may be done by means of tannic-acid jelly1 dressings or by use of any fresh, bland oil, such as cream, vaseline, liquid petrolatum, olive oil, etc. If the burn has been caused by a caustic such as an acid or an alkali, the acid should be neutralized with bicarbonate of soda or ordinary baking soda, and the alkali by a weak solu- tion of acetic acid or ordinary vinegar before the burned area is covered. In burns of the second and third degree the quickest temporary means of excluding air is to immerse the part or the entire body in warm water; then, having everything in readiness, carefully cut away the clothing, leaving such as may be sticking to the burned skin; blisters should be left undis- turbed unless they are very tense and painful, when they may be punctured by a sterilized needle, and the content allowed to escape. The application of tannic-acid jelly dressings should then follow and the patient be put to 1 Tannic-acid jelly is carried as an item on the Supplementary Supply Table and a good supply should always be kept on hand and available for immediate use. 117 MINOR SURGERY AND FIRST AID bed. Later, the raw areas where the outer tissues have been destroyed may be treated by a freshly prepared 5 per cent aqueous solution of tannic acid applied either by an atomizer or by sterile cotton applicators. Several coats of the tannic acid solution are applied to all raw areas while an assistant fans the areas to promote the “tanning” process. The solution of tannic acid is use- less for the treatment of first-degree burns in which the skin is intact for it will “tan” only raw areas. Following several repeated applications of the tannic acid solution the whole area is next treated with a 10 per cent silver nitrate solution applied with sterile cotton swabs. After the application of the silver nitrate solution, which is germicidal in its action and helps prevent infective organisms from growing beneath the “tanned” areas, a black pellicle of skin quickly forms beneath which new tissues grow and spread. Whenever possible burns should first be treated by the tannic-acid method. (See formulas under Tannic Acid in section on Materia Medica.) In this method the tannic acid unites with and “tans” the tissues in the raw areas. When “tanning” is complete the burned areas have become dark-brown in color, and when they have dried they are covered with a hard, leathery crust of a dark- brown or black color. This crust: 1. Keeps the burned areas aseptic except when infected material has been covered over by it; 2. Lessens the possibility of infection as ordinarily infective organisms cannot penetrate through it; 3. Protects sensory-nerve endings from external stimuli and thereby lessens pain and suffering; 4. Prevents loss of water from the injured tissues and loss of body heat; and 5. Serves as a protective covering for the new tissues forming and growing to replace those which have been destroyed. Unless infection occurs beneath it the crust should not be disturbed until it begins to curl up at the edges and to peel off of its own accord, when the loosened parts may be cut away with sterile scissors. The effectiveness of this method of treating burns is seriously interfered with if oils, ointments, or other greasy substances have previously been applied to the burned areas. Any oil, ointment, or grease that is present must be gently but thoroughly removed with sterile swabs and the area sponged with a weak solution of sodium bicarbonate before the tannic-acid treatment is begun, even though it may cause considerable suffering. In rendering first aid at a fire the points to be kept in mind are: Prevent drafts from fanning the fire. Shut and keep shut all doors and windows. If one’s own clothing catches afire, do not run, as this fans the flames; lie down on the deck or a bed and roll up as tightly as possible in a rug, shawl, overcoat, blanket, or other woolen cloth, leaving only the head out; if nothing can be obtained in which to wrap up in, lie down and roll over slowly, at the same time beating out the fire with the hands. If another person’s clothing is on fire, throw him to the ground and smother the fire with a coat, blanket, rug, or the like; in doing this care should be taken to stand at the head, and, holding down with one foot one edge of the blanket or whatever is used, to throw it toward the feet of the individual; the flames thus are swept away from the rescuer and from the face of the burning person. Remember that the air within 6 inches of the deck is free from smoke, so when unable to breathe a rescuer should crawl along the floor with the head low, dragging anyone who has been rescued behind him. The rescuer should tie a wet handkerchief or cloth over the mouth and nose to minimize the danger of suffocation. Cold or chilling.—Injuries due to cold are classified as general, or consti- tutional, not local. Prolonged exposure to extreme cold results in a general depression or lowering of the vitality, a gradual chilling of the body, and a congestion of the internal 118 HANDBOOK OF THE HOSPITAL, CORPS, U. S. NAVY organs. The body and limbs first feel numb and heavy, and then become stiff; drowsiness and an irresistible desire to sleep take hold of the individual. If left alone, unconsciousness rapidly follows. When found in such a condi- tion, life not yet being extinct, a person should be taken into a cold room, all clothing removed, and the body rubbed briskly with sheets or towels wet with cold water. As soon as the stiffness is removed artificial respiration should be performed; and when the patient is able to swallow, warm drinks should be given. When there are signs of returning consciousness and cir- culation the body may be enveloped in a* blanket and the temperature of the room gradually raised. The reason why a frozen person must not be removed to a warm room is that the sudden restoration of the circulation gives rise to violent congestions and often to sudden death from the formation of clots in the blood vessels. , In intense cold, frostbite not infrequently occurs without one’s knowing it, but usually the ears, fingers, etc., become painfully cold, and then one sud- denly realizes that no longer is there any feeling in the parts. The color of the frozen part is white or grayish white. The object of treatment is to bring the frozen part gradually to its normal temperature. The danger of sudden thawing is congestion and bursting of the capillary walls which have been weakened by freezing, and resulting in gangrene or death of the part; therefore the patient should not go into a warm room or near a fire. Rub the part vigorously with wet snow or ice water; never with dry snow, as the temperature of the dry snow may be much below freezing and rubbing with it would aggravate the condition. When the pain and redness return use warm water gradually. Chilblain is a condition of acute or chronic con- gestion occurring especially in the feet and due to bringing cold feet near the fire too suddenly or merely following exposure to cold in persons with poor circulation. On the part affected are red spots, more or less swollen, which burn and itch intensely. The treatment consists in stimulating applications, such as liniments and tincture of iodine. Susceptible persons should wear woolen socks. REMOVAL OF FOREIGN BODIES Either inanimate objects such as splinters, cinders, marbles, peas, beans, etc., or animate objects such as insects, maggots, ticks, etc., may gain access to the tissues and cavities of the body. With regard to the removal of inani- mate foreign bodies, if their removal is difficult or liable to be attended with much damage to the tissues, the patient should be brought under the care of a surgeon as soon as possible for the removal of the foreign body. If the services of a medical officer are not to be had for some time, then the first-aid man must be guided by the probable relative benefit to the patient of having him wait the required time for expert treatment or of doing the operation himself. The main principle to be kept in mind in the removal of an inanimate foreign body is to avoid infecting the tissues, by using sterile appliances, and to do as little damage to the tissues as possible. The main principle underlying the treatment of conditions where insects, etc., have gained access to tissues and cavities of the body is to kill the object first and then remove it. Creatures such as Insects and ticks are best killed by putting some bland oil, such as olive oil or liquid petrolatum, into the cavity to which they have gained access, the oil covering over their breathing pores and thus suffocating them, after which they usually may be easily washed out. Foreign bodies in the eye.—Foreign bodies, such as particles of dust, cinders, etc., may lodge under the lids, upon the conjunctiva, or upon the cornea. In MINOR SURGERY AND FIRST AID 119 the latter situation they are seen and removed with the greatest difficulty, and the removal ordinarily should not be attempted by other than a medical officer. To remove a foreign body from the eye one end of a wooden appli- cator should be wrapped with cotton and dipped in boric acid solution, and then drawn lightly across the eyeball or eyelid with a wiping movement. Never attempt to lift off or dig out a foreign body from the eye. Probably the best improvised article for removing a foreign body from the eye, and one that nearly always is at hand, is a match, which may be used in the same way as a wooden applicator, the plain end being covered with cotton or with a clean handkerchief. Or, the match may be lighted, allowed to burn a moment, and the flame blown out; then, with a clean handkerchief and a rolling movement of the fingers twist off the charred end which leaves a soft, clean, splinterless surface with which to wipe away the foreign body. To examine the lower lid, draw it down with the fingers, at the same time having the patient look up; if the foreign body is not found there, evert the upper lid by standing behind the patient with the head upon your chest, and telling the patient to look down; at the same time press a match or the end of the finger firmly against the outside of the lid about a quarter of an inch behind its margin. Draw the lid down by the lashes, and turn it upward and outward over the match or finger tip. If the particle still is not visible, search thd ball of the eye carefully for it, and when it is found, lift it off gently by a quick movement with the point of the match. If the eye is very irritable, it may be necessary to put in a few drops of 2 per cent cocaine solution. It is important to remember that even after a foreign body is removed from the eye there is often for some time a sensation as if it were still there. After removing a foreign body the eye should be irrigated with boric acid solution and a few drops of 5 to 10 per cent silvol solution instilled. Foreign bodies in the ear.—The foreign body may be an insect, a pea, a grain of wheat, a pebble, a plug of hardened wax, etc. An insect in the ear by its movements and buzzing often causes the most intense annoyance. Hold the head over on one side with the ear containing the insect uppermost; drop in 5 or 10 drops of bland oil, such as olive oil or liquid petrolatum, and then syringe the ear; or fill the canal with water which will cause the insect to float to the surface from where it can easily be removed. If the foreign body is vegetable, such as a pea, water should not be used, as it may cause the pea to swell and thereby render its extraction more difficult. If the pea is visible, bend the loop of a fine hairpin and try to get beyond it so as to hook it out. As there is always danger of injuring the eardrum when instruments are pressed into the ear, it should be a guiding rule that no instrument should be passed beyond the point where its tip can be seen. Hardened wax may be softened with a few drops of hydrogen peroxide, then removed by syringing with a warm 5 per cent solution of soda. Foreign bodies in the nose.—Children and insane persons often push peas and other foreign bodies into the nose, and occasionally flies deposit their eggs there with the result that maggots develop in the nasal cavity. Foreign bodies are best removed by closing the free nostril with the finger and forcibly blowing through the obstructed side; snuffing a little powdered tobacco or pepper will cause sneezing and aid in the expulsion; if this does not succeed and the body can be seen, it may be hooked out with a bent hairpin in the same manner as described for the ear. Should these measures fail to remove the foreign body it should be left alone until the patient can be brought to a medical officer. The presence of maggots in the nose is a very serious condition, which 120 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY may result in death. Let the patient inhale through the nose a half teaspoon- ful of chloroform, and while the maggots are stupefied syringe them out with warm physiological salt solution. Foreign bodies in the throat.—Foreign bodies in the throat are usually bones or masses of food. If the bone dan be seen and reached, it may be removed by fingers or forceps; if not, it may be carried down by eating dry bread. If the obstruction is a mass of food, it may be dislodged by forcible blows on the back between the shoulders or the fingers may be passed into the throat to hook it out or to cause its ejection by vomiting. Foreign bodies in the air passages cause violent coughing and difficult breathing; the case is urgent, and in the case of a child, he may be held up by his heels and shaken; if an adult, inversion also may be attempted and the case treated as described for foreign body in the throat. Foreign bodies in the stomach.—Foreign bodies sometimes are swallowed and reach the stomach and intestine. Such cases are not usually serious. If the body is angular or pointed, such as a tack or pin, feed the patient on sub- stances which leave considerable residue to cover and protect the sharp points— potatoes, bananas, bread, etc. Do not give laxatives, as they will render the bowel movements liquid and thus leave sharp points exposed and because the in- creased peristalsis favors injury to the intestinal walls. The patient should, however, be brought under the care of a surgeon. Foreign bodies in the skin.—Here are found splinters, thorns, needles, pins, fishhooks, pieces of glass, gunpowder, etc. For splinters and thorns pass the point of the blade of a pocketknife under them; with the thumb-nail press the splinter against the blade and draw it out; or use a pointed dissecting or dressing forceps. If the splinter is buried, open up the skin a little with the point of a knife or a needle until it can be reached; if under a nail, cut a notch in the nail so as to expose it. If a needle or a pin is broken off in the skin and cannot be grasped with forceps, cut a small hole in the end of a cork and press it down over the point of entrance of the needle; this may cause the needle to emerge so far that it can be grasped. The needle may be so situated that it is best to push it through and extract it on the other side. If the needle or pin is in the foot or the hand and cannot be extracted, the patient should be directed not to use the part, as muscular action will cause it to work in deeper. A fishhook or an arrow cannot be drawn out on account of the barbs; they must be pushed through. Gunpowder is removed best by a thorough scrubbing with soft soap and a stiff brush, the remaining grains being picked out with a needle. ASPHYXIA Asphyxia is a condition where respiration, or breathing, has ceased. It may be the result of either abnormal physiological or physical causes. When due to the latter it may be spoken of as suffocation. Among the physiological causes of asphyxia are: Lack of stimulation of the respiratory center in the medulla oblongata, paralysis of the respiratory center, and inability of the blood to absorb oxygen from the lungs or to effect the normal exchange of gases in the body tissues. In asphyxia resulting from physical causes the lungs are deprived of air because of stoppage of the air passages mechanically, as by water in drowning, by a foreign body, by a diphtheritic membrane extend- ing into the larynx, by a tumor, by swelling of the mucous membranes follow- ing inhalation of live steam or an irritating gas, by a constricting band around the neck compressing the trachea; or because of the presence or irrespirable gases in the air. 121 MINOR SURGERY AND FIRST AID The treatment is to first remove the cause or remove the patient from the cause, then give artificial respiration, and later treat for shock. Artificial respiration.—There are several accepted methods of applying arti- ficial respiration but the best and probably the least dangerous is the prone pressure or Schaefer's, method (fig. 64). No reliance should he placed upon Expiration ; pressure on. Inspiration ; pressure off. Figure 64.—Prone pressure or Schaefer’s method of artificial respiration. (Keen.) any special mechanical apparatus, as it is frequently out of order and often is not available when most needed. The prone pressure method of artificial respiration is as follows: Lay the patient face downward on a blanket or clothing spread out flat with the head turned to one side. The arm on the side toward which the face is turned is extended beyond the head, the other is bent at the elbow and the hand or forearm placed beneath the head. The operator kneels astride of both or of one of the patient’s thighs, facing toward the head and places the palms of his hands on the lower part of the thorax, the little fingers touching the lowest ribs and the ends of the fingers just out of sight. (If only one thigh is straddled it should be the one on the side toward which the patient’s face is turned so that his face can be easily observed.) Then, keeping the arms straight, the operator swings his body slowly forward, causing the hands to press upward and inward. This compresses the abdomen and the lower part of the thorax, forces out the air in the lungs' and produces an expiration. At the end of the forward swing the operator’s shoulders should be directly above the heels of his hands. Hold the pressure momen- tarily and then quickly remove it by swinging backward to the original position, which permits the thorax to expand and produces inspiration. After a wait of a couple of seconds swing forward again. The alternate compression and release movements together should take about 4 or 5 seconds and should be repeated rhythmically 12 to 15 times a minute. As an aid in timing the movements the operator may repeat the following words to himself: “Forward slow, hold it, swing back, wait a second.” In swinging backward the operator’s hands should not be removed from the patient, and he should adjust his position so that he can easily maintain his balance during the movements. The patient’s mouth should be cleared of any obstruction such as chewing gum or tobacco, false teeth, or mucus so that there is no interference with the entrance and escape of air. To keep the patient warm during artificial respiration is most important and it may be necessary to cover him with blankets and work through them, as well as to apply hot-water bottles, hot bricks, etc. Artificial respiration may be required in those persons apparently drowned; asphyxiated by gases, fumes, or noxious vapors, and anaesthetics; electric shock; shock or collapse; freezing or exposure to extremes of heat or cold; cases of poisoning, etc.; in other words, in all cases in which breathing is temporarily suspended. The symptoms by which the necessity for artificial 122 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY respiration may be recognized' are: Cyanosis (blueness of tbe skin and mem- branes) ; suspension of respiration; or shallow breathing in some cases of poisoning. Artificial respiration should be continued for at least 4 hours with- out interruption or until the patient is pronounced dead by a medical officer. Treatment for a person apparently drowned.—Every minute and second counts, so waste no time. Have bystanders move away to give the victim all the air possible. Loosen clothing about neck, chest, and abdomen. With handkerchief or towel in hand, gently swab out the mouth and throat to remove mud or mucus. Turn the patient over, face downward, place the hands under the abdomen, one on either side, and lift the patient, in an endeavor to drain the lungs and stomach, then with a large roll of clothing under the abdomen, and by making firm pressure upon the loins, continue the efforts to expel the water from the lungs and stomach. If the individual then does not breathe, proceed immediately with artificial respiration. It is well at the same time to try to stimulate respiration by having an assistant hold ammonia or smelling salts to the nostrils. Recovery from drowning has occurred where persons have been submerged for some minutes; the statements of observers as to length of time of immersion can never be accepted, as in emergencies of this sort minutes seem like hours. When breathing has been reestablished, remove wet clothing and treat the shock. Treatment for a person asphyxiated by hanging or by strangulation.—Promptly remove any constriction from the neck and also clothing from around the chest. Attempt to excite breathing by dashing cold water on the face and body; if this fails, proceed with artificial respiration. Treatment for a person asphyxiated by choking.—The choking may he due to a foreign body or to such a thing as a diphtheritic membrane. Make an attempt to remove the offending material as described in a previous paragraph. In many of these cases it will be necessary to do a tracheotomy, that is, cut a hole in the windpipe, or in diphtheritic cases, to do either an intubation or a tracheotomy. This, however, must be done by a surgeon and no time whatsoever must be lost in bringing the patient under his care. After removal of the obstructing material, perform artificial respiration in the manner described previously. Treatment for asphyxiation from poisonous gases.—Illuminating gas and the exhaust gases from gasoline engines are the most common causes of gas poison- ing. It is the carbon monoxide in these gases which is responsible for the dam- age. When carbon monoxide is in sufficient concentration in the air being breathed it forms a stable compound with the haemoglobin of the blood; this prevents the haemoglobin from taking up oxygen and carrying it to the tissues. The patient must be removed as soon as possible into the fresh air and artificial respiration instituted. In the meantime send for a medical officer, as it often becomes necessary to let out some of the patient’s blood and substitute therefor good blood from some one else (transfusion). A person poisoned with carbon monoxide presents a cherry-red appearance on cheeks and lips. Insensibility and unconsciousness are one and the same thing. There are varying degrees of unconsciousness, and the same agent causing partial un- consciousness, if further applied, may cause total unconsciousness. There are numerous causes for unconsciousness, and in order to properly treat it the cause must be discovered. To treat a case of unconsciousness is one of the most difficult things that may fall to the lot of the first-aid man. In all UNCONSCIOUSNESS 123 MINOR SURGERY AND FIRST AID cases of unconsciousness strenuous efforts should be made to bring the patient under the care of a medical officer as soon as possible. To ascertain the cause of unconsciousness, the first-aid man should be very observant of the surroundings as well as of any evidence on the person of the patient which might give a clue to the cause. If there are any observers on the ground or any who are acquainted with the patient’s habits and past history, all informa- tion possible should be obtained from them. The patient’s body should be ex- amined for evidences of injury, bleeding, or paralysis. It should be noted whether the skin is moist and cold, or hot and dry. The character of the respirations should be noted, whether deep, strong, and fast, or whether weak, shallow, and slow. It should be noted whether the pulse is weak and shallow, or whether it is bounding and strong. The condition of the pupils should be noted; whether they are even or uneven, dilated or contracted. The breath should be smelled for evidence of alcohol, and a note made whether there is frothing at the mouth or injury to the tongue. The common causes for unconsciousness are asphyxiation, bleeding, shock, electric shock, heat exhaustion, freezing, sunstroke, epilepsy or fits, apoplexy and injury to the brain (concussion and compression), alcoholism and certain other poisons, hysteria, and uraemia. For the symptoms and treatment of suffocation, bleed- ing. shock, heat exhaustion, sunstroke, and freezing, see previous paragraphs. Electric shock is caused by coming in contact with a “live wire”; spasmodic contraction of the muscles occurs so that the person cannot let go. Depend- ing on the strength of the current in the wires in contact with the patient, sud- den death or insensibility, with or without severe burns, may be caused. The first thing to be done is to rescue the patient by setting him free from the wire, and this must be done with great care, as to touch him with bare hands will cause the rescuer to get the same shock. With a single quick motion, free the victim from the current. Use any dry nonconductor (clothing, rope, board) to move either the victim or the wire. Beware of using metal or any moist ma- terial. While freeing the victim from the live wire have every effort also made to shut off the current quickly. Immediately start artificial respiration, and when voluntary breathing returns, treat for shock. The burns must be treated as other burns. Lightning stroke causes similar symptoms to the foregoing and the treatment is the same. Epilepsy or fits.—In epilepsy there may be fits with insensibility, or a mere momentary unconsciousness with slight muscular twitching, but in which the patient does not fall. In the severe form, with or without warning signs, the person suddenly cries out in a peculiar manner and falls in a fit; at first the entire body is rigid, then there are general convulsions with jerking of the limbs, contortion of the face, and foaming at the mouth. After a few minutes the convulsions are followed by profound stupor, and this generally passes off into a deep sleep. During the attack the eyeballs may be touched without the patient flinching, the pupils are dilated, the patient often bites his tongue, and there may be involuntary evacuations of the bowels and bladder. Epileptic un- consciousness may be distinguished from other forms by the history of the fit, and of other previous fits, by the foam at the mouth and the bitten tongue and by the absence of any paralysis. As far as treatment goes, nothing can be done to stop the fit or to control it; all that can be done is to prevent the patient from hurting himself and to make him as comfortable as possible; do not attempt to hold him, but twist a handkerchief, passing it between his jaws, and tie it at the back of the neck until after the fit is over to keep him from biting his tongue. After the fit is over let the patient sleep as long as he will. One must be on the 154294°—39 9 124 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY lookout in the service for men feigning epileptic fits in order to obtain a dis- charge. The feigned attacks usually occur at night when no one can see them; the man does not fall so as to hurt himself, does not bite his tongue, flinches when the eyeball is touched, the pupils are not dilated and the patient can be aroused. When there is foaming at the mouth a piece of soap often will be found inside the mouth. A pail of cold water suddenly thrown upon the man’s head and shoulders usually makes the diagnosis; it promptly revives the malingerer, but has little or no effect on the epileptic. Concussion of the brain.—Concussion of the brain is a condition present when a man has been ‘“knocked senseless” or “stunned.” It is a jarring and shaking of the brain due to blows or falls upon the head or falls upon the feet; the brain almost stops working for a time. The symptoms are un- consciousness, pallor of the face, breathing so quiet and shallow that it hardly can be detected, pulse fluttering, pupils equal and usually contracted. The degree of insensibility varies. Sometimes the patient can be aroused, but is irritable, and lapses again into unconsciousness which may last minutes or hours. Vomiting and turning on the side are favorable symptoms. The treatment consists in perfect rest in a dark, quiet room; warmth applied externally if the surface is cold; and aromatic spirits of ammonia by inhalation if there is much depression. Compression of the brain and apoplexy.—Compression of the brain is, as the term implies, a pressure on the brain. This pressure is due usually to either a piece of bone or to a haemorrhage from a torn vessel within the cranium, and as the blood cannot leave the cranial cavity it compresses the brain. This compression prevents certain parts of the brain from working. When the bleeding is the result of injury the condition is called compression of the brain; when it is the result of the bursting of a diseased blood vessel without any violence it is called apoplexy; the result and the symptoms are practically the same. The symptoms of compression are profound unconscious- ness ; loud, snoring breathing; slow pulse; pupils usually unequal and not reacting to light; and usually paralysis on one side of the body. If the compression is due to a piece of broken bone, the symptoms come immediately after the injury, while if it is due to bleeding they may come on later and gradually. The treatment of both compression and apoplexy consists of keep- ing the patient absolutely quiet, at rest in a comfortable position, and applying cold applications to the head during the acute stage. Do not administer stimulants. When convalescent, regulate diet, recommend a very moderate amount of exercise, and instruct the patient to avoid worry and excitement. Hysterical unconsciousness.—-Hysteria is a disease, of the nervous system accompanied by loss of control over the emotions. It usually is seen in women, but also may be present in nervous men. The disease is manifested in a great variety of ways, but the only form that will be mentioned here will be that accompanied by convulsions. In this form hysteria may closely resemble epilepsy. The patient usually has an attack of laughing and crying and gradually “works himself up” to such an extent that he falls in a con- vulsion. The attacks sometimes are prolonged for several hours, and upon recovery, it is not uncommon to find the patient laughing or sobbing for some time after. He appears to be unconscious, but in falling he always picks out some soft spot or chair to fall upon, and is careful not to injure himself. The tongue rarely is bitten in hysteria. Hysteria may be mistaken for epilepsy, but in the latter condition the fall is sudden, and the sufferer fre- quently receives painful scalp wounds or injuries to the tongue. While hysteria is a disease, the patient nevertheless should be treated with firm- 125 MINOR SURGERY AND FIRST AID ness. The subjects usually crave sympathy. To sympathize with such a patient is the worst possible thing one can do and simply prolongs the attack or hastens another. The best thing to do is to leave the patient alone —of course seeing that no harm can come to him. When he recovers and finds himself alone and without sympathy it is not likely that he will repeat the attacks. In prolonged convulsions, throwing -water in the face usually will terminate the seizure. Uraemia or the insensibility of Bright’s disease.—The insensibility of Bright’s disease is really an acute poisoning from the retention of the waste products which the diseased kidneys are not able to eliminate. The unconsciousness often is attended with delirium and convulsions. The pupils are contracted, the pulse is slow, there is a peculiar odor of the breath, and the breathing is loud and snoring. The distinguishing characteristics are the history of Bright’s disease, the waxy color of the skin, sometimes dropsy, abnormal urine (albumin, casts, etc.), and ordinarily the absence of paralysis. Emergency treatment consists in applying cold cloths to the head and a hot mustard poultice to the back over the kidneys. If the services of a medical officer are not available within a brief period of time, catheterize, and give an enema and a hot pack. Unconsciousness caused by acute alcoholism.—The use of alcohol, if carried to excess, produces a condition of unconsciousness which is very likely to be confounded with other similar conditions. Too great care cannot be taken in examining these cases thoroughly, as mistakes are of frequent occurrence, and cases of fractured skull or apoplexy often are pronounced mere alcoholism. Do not be led astray by the fact that a person has an odor of liquor about him. He may have been drinking and had a stroke of apoplexy, or may in falling have fractured his skull. If there is the least doubt, it is better to give the patient the benefit than to run any risks. A person suffering from alcoholic coma lies in a stupor, but usually can be partially aroused and made to answer questions. The face is flushed, the pulse is first full and rapid then feeble and slow, and the respirations are deep. The pupils usually are dilated and the breath has the heavy odor of alcohol. Ordinary intoxication rarely requires any treatment besides rest and sleep. If the patient is in an exhausted state, it is well to wash out the stomach, then cover him warmly and apply heat to the extremities. If coma is present, try to arouse the patient by cold douching or striking with wet towels. If the pulse is weak, stimulants should be given; inhalations of ammonia and the internal use of strychnine or caffeine may be employed if the patient is conscious. The use of strong coffee by the rectum is often of great service. When unable to diagnose exactly the cause of unconsciousness determine, if possible, that it is due neither to a poison, to bleeding, nor to sunstroke, for each of these demands immediate special treatment, nor to suffocation, for which it would be necessary, of course, to give artificial respiration. Then, unless it is necessary to give the special treatment, if the patient is pale and weak, have him lie down with his head low, apply warmth and stimulate him in every way possible; on the contrary, if the face is red and pulse is very strong, while the position for the patient should also be lying down, the head should be raised. No stimulants should be given in the latter condition, and cold water should be sprinkled on the face and chest. After a patient has been taken to the sick bay or the hospital Bogan’s test to determine the amount of alcohol per cubic centimeter of circulating blood or in the urine may be used in doubtful cases of unconsciousness where alcoholism is suspected, but this test does not rule out poisoning, head injury, etc., which can and frequently do accompany alcoholism. 126 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY ACUTE ABDOMINAL CONDITIONS The most common, serious, acute abdominal conditions are acute appendi- citis, perforating ulcers of the stomach or duodenum, intestinal obstruction, gall-stone colic, kidney-stone colic, and poisoning by infected food or by other poisons. Pain and tenderness in the abdomen, general or localized or both, nausea and vomiting, and more or less shock are symptoms common to these conditions. Beginning pneumonia, lead poisoning (painters’ colic), and inflam- mation of the testicle are conditions outside of the abdomen which may produce similar symptoms. Acute indigestion and constipation are compara- tively mild conditions which may be confused with these conditions. Many cases of acute appendicitis, obstruction of the bowels, and acute pancreatitis that have been diagnosed as acute indigestion or constipation have resulted in the death of the patient. All cases presenting symptoms of abdominal pain or nausea and vomiting, particularly when associated with more or less shock, should be brought under the care of a medical officer as soon as possible, as time is a very important element in averting a fatal end in many of these conditions. One always should suspect something more than ordinary indigestion or constipation if there is much prostration, shock, or elevated temperature, or if the symptoms persist for any length of time. Many a person suffering from acute appendicitis or obstruction of the bowels will ascribe the condi- tion to something that has been eaten, but do not be deceived by such a statement. Get all the information possible as to how the attack started, history of previous attacks, and symptoms prior to the present attack, whether the patient has vomited blood or not, and when the bowels last moved; take the temperature and pulse rate; lay the patient flat with the abdomen bared and determine by gentle and careful palpation where the pain and tenderness are most marked. Make a white blood count if possible. Acute appendicitis.—Appendicitis is an inflammation of the appendix. A patient frequently complains for several days before the attack of indiges- tion, loss of appetite, constipation or diarrhoea, and uneasiness in the abdo- men, or the attack may come on suddenly. The pain may start in the pit of the stomach, then become generalized over the abdomen, and finally, after several hours, become localized in the right lower quadrant of the abdomen with marked tenderness on pressure and rigidity of muscles over that point. Vomiting generally comes on 3 or 4 hours after the beginning of the attack. The temperature may be subnormal from mild shock or be elevated to 100° or 101° F. There is generally an increase in white blood cells to above 10,000 per cubic millimeter. In acute appendicitis the appendix becomes full of pus and the danger lies in its rupture with resulting peritonitis. Many cases never rupture, whereas others often rupture in 3 or 4 hours after the attack starts. The object is to remove the appendix before its rupture, as otherwise death may ensue from peritonitis, or the abdomen may have to be drained for months with or without final recovery and perhaps result- ing in the formation of adhesions, making the patient more or less a permanent invalid. The treatment consists in placing the patient under the care of a surgeon as soon as possible. In the meantime put to bed, giving nothing by mouth, not even hot water; give a soap and water enema very low and under very little pressure, and put a hot-water bag over the appendix. Do not use an ice bag. In case no medical officer is available for some time, liquids in small amounts may be given after 48 hours. Never give a cathartic to a person suspected of having acute appendicitis. MINOR SURGERY AND FIRST AID 127 Acute intestinal obstruction.—In this condition, a loop of bowel becomes constricted, resulting in the inability of the intestinal contents to move beyond the point of constriction and cutting oft the blood supply to the loop of the bowel with resulting gangrene or death to the bowel. This condition is followed by absorption of poisons from the intestine, peritonitis, and death if the condition is not relieved. Two very common ways for the bowel to become constricted are by means of adhesions within the abdomen and by a loop of bowel becoming strangulated in a hernia, or rupture, as it is commonly called. The symptoms are inability to pass gas or faeces by the rectum, pain in the abdomen, vomiting becoming more and more frequent, and intense shock. The abdomen may be distended above the point of constriction and be flat below that point. There is generally a leucocytosis as in appendicitis. The loop of bowel must be relieved of its constriction or death will ensue. Place the patient under the care of a surgeon at the earliest possible moment. In the meantime, take the following measures: 1. If the obstruction is due to a strangulated hernia, and the case has not gone too far, put the patient in a hot tub with the buttocks elevated in order to relax the inguinal ring, and exert gentle pressure over the tumor; 2. Put the patient to bed, give a soap and water enema, and nothing by mouth. Never give a person suspected of suffering from obstruction of the bowels a purgative. Perforated gastric or duodenal ulcer.—Generally, though not always, a person suffering from perforated ulcer of the stomach or duodenum gives a long his- tory of stomach trouble. Acute pain “in the pit of the stomach,” associated with more or less shock, is suddenly felt. The pain is sudden and intensely violent, which is greatly increased by swallowing fluids, by vomiting, by turn- ing the body, by coughing, by respiration, and by pressure. This pain may radiate throughout the abdomen, but the chief tenderness is in the region of the stomach. Vomiting occurs in about one-half the cases at the time of perforation. Shock may be severe following the perforation, but, as a rule, does not last long. A board-like rigidity of the muscles of the abdomen is present, and the temperature is usually normal or subnormal. The danger from per- forated ulcer of the stomach or duodenum is peritonitis, due to the escape of stomach or duodenal contents into the peritoneal cavity. The treatment con- sists in bringing the patient under the care of a surgeon as soon as possible before peritonitis sets in; in the meantime, put the patient to bed, give abso- lutely nothing by mouth, and put an ice bag over the stomach; and treat shock and haemorrhage if present. Gall-stone colic.—Gall-stone colic is due to the passage, or the attempt at passage, of a gall-stone from the gall bladder to the intestines. Depending on the location of the stones, a person with gall-stones may or may not be jaundiced. The patient frequently gives a history of stomach trouble with or without jaundice and may give a history of previous gall-stone colic. The colic consists of spasmodic, excruciating pain over the stomach and liver, radiating upward over the right half of the thorax, frequently up under the right shoulder blade. The patient is very nauseated, and usually vomits, and often the vomiting is violent. The abdomen is distended and a condition of collapse soon comes on. The respirations are shallow, the patient groans, cries out, or flings about the bed, often assuming strange contorted positions, trying to obtain relief, frequently holding one hand over the liver region. The pain is one of the most excruciating a human being can experience. The usual duration of an attack is from 4 to 20 hours, although it may last much longer. The temperature is usually normal or subnormal. The patient should be brought under the care of a medical officer as soon as possible. If one is not 128 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY at hand, give one-fourth grain of morphine hypodermically, followed in an hour by another one-fourth grain, and place a hot-water bag over the liver at the lower border of the ribs. Kidney-stone colic.—This condition is due to a small stone from the kidney entering into the ureter, which it blocks, tears, or distends. The pain is gradual or sudden in onset, is fearful in intensity, and runs from the lumbar region down the corresponding thigh and testicle and into the abdomen and back. There are nausea, vomiting, collapse, and sometimes unconsciousness or con- vulsions. Frequent attempts at urination result in j)ain but little urine. The urine is often smoky or red from injury to the ureter. After a time the pain vanishes, due to the stone falling back into the pelvis of the kidney or to its passing on into the bladder. Treatment consists of bringing the patient under the care of a medical officer, and, in the meantime, putting to bed, giving plenty of water by mouth to increase the flow of urine, putting a hot-water bag on the affected side of the abdomen, and, if necessary, giving morphine, one-fourth grain hypodermically. Poisoning causing acute abdominal symptoms.—If the condition is due to eat- ing infected foods containing toxins or harmful breakdown products formed by the action of bacteria on the food it is probable that more than one person will apply for treatment. The symptoms are vomiting, diarrhoea (at times bloody), fever, abdominal cramps, and sometimes considerable prostration. In the ab- sence of a medical officer, clear out the intestine with a good dose of castor oil. If a severe case occurs, put the patient to bed, give a purge, and allow nothing by mouth except plenty of water, until symptoms abate, then increase diet gradually. Should severe constipation be present an enema of soap and water may be given. In case the acute abdominal symptoms are due to inflammation of the testicles, there usually will be a history of urethral infection, or mumps, or injury to the testicle, and on examination the part wall be seen to be tender and swollen. Lead poisoning may resemble in its symptoms any acute abdominal condition mentioned, particularly acute intestinal obstruction and appendicitis; in this case, however, there is a history of working with lead, paint, or in compart- ments laden with lead paint chippings; the so-called “blue line” at the margin of the gums most likely will be present, and a blood smear stained with Wright’s stain will show stippled red cells and probably anaemia. In case the symptoms are due to a beginning pneumonia, there usually will be a histpry of chills a short time before, the respiration will be increased with a rising fever, and perhaps a beginning cough with sputum. There is generally a high leucocytosis, even up to 80,000. The main principles a first-aid man should remember when treating a ease with acute abdominal symptoms are: 1. No purgative should be given when appendicitis or intestinal obstruction is suspected; 2. The time elapsing before surgical aid can be obtained is of the greatest importance for the future welfare of the patient; 3. No morphine or opium should be given for pain except in frank eases of gall-stone and kidney-stone colic, as this will mask the symptoms for the surgeon when he arrives. SOME COMMON EMERGENCY SYMPTOMS Fever is a name given to a group of symptoms consisting of a rise of temper- ature above normal (98.6° F.), with attendant increase in the pulse rate and a rise in the number of respirations per minute; associated with which are generally headache and flushing of the face, a feeling of weakness, irritability, MINOR SURGERY AND FIRST AID 129 and loss of appetite. Fever is simply a group of symptoms and is not a disease in itself. Fever is one of the main symptoms of all infectious diseases and infections and for some time may be the only evidence of an infection or an infectious disease. It may, however, simply be due to the results of constipa- tion, with absorption of poisonous products from the intestine, but as a rule the temperature in these cases does not go above 101° F. In handling a fever case, if possible bring the patient under the care of a medical officer. The problem in a case of fever is to find the cause if possible. Get the history of the ease, how long there has been fever, what other symptoms have been or are present; if there has been exposure to an acute infectious disease, or con- stipation ; and examine the throat and skin for evidences of the cause. If no other symptoms are present but an acute fever, which is not very high, and if the patient is not particularly sick, a good purgative probably will give relief. Do not load up the patient with drugs. Constipation with fever is spoken of as autointoxication. If the patient has a high fever and is sick, give a brisk purgative, put to bed on a liquid diet, and put an ice bag on the head. In the meantime try to obtain the services of a medical officer and watch the patient carefully for symptoms which will point the way to ascertaining the cause of his fever. In case the beginning of an infectious disease is suspected the patient, of course, should be isolated. A cold.—The term “cold” is applied to a group of symptoms consisting of a running at the nose, lacrimation (overflow of tears), and fever, generally with headache and malaise (opposite of well-being). These symptoms may be due to a so-called common cold or they may be forerunners of such infectious diseases as influenza, measles, infantile paralysis, or cerebrospinal fever. If the patient is quite sick, fever high, and depression is marked, particularly if there has been exposure to the above-mentioned infectious diseases, suspect that it is something more than a common cold, and, if possible, place the patient under the care of a medical officer. Find out whether the patient has been recently exposed to such diseases, and by questions and examina- tion ascertain whether further symptoms are present which may lead to a diagnosis. Give the patient a brisk purgative; isolate, and keep on the lookout for further symptoms. If the case is one of common cold, a brisk purgative should be given early, the patient advised to drink plenty of water, and hot drinks given at night, possibly with 10 grains of aspirin, or Dover’s powder, to stimulate perspiration. Headache.—Headache may be due to a great variety of causes. It is a con- stant accompaniment of fever, of acute infectious diseases, of autointoxication, and of head injuries. It frequently is due to eye strain. In all eases of headache it is well always to take the temperature and to inquire into the condition of the patient’s bowels. There must be a cause, and the problem is to find it. Do not try to cure headaches with drugs without trying to find out the cause, except perhaps in emergency 10 grains of aspirin may be given after a good purgative. Patients with frequent headaches should always consult a medical officer when available- Diarrhoea.—Diarrhoea is a term applied to a condition characterized by the passage of frequent, watery stools. It may be due to diseases such as dysen- tery, meat or other poisoning, typhoid or other fever, or simply to the presence in the intestine of some irritating material from fermentation and putrefac- tion. Always take the temperature of a person suffering from diarrhoea; ques- tion and examine for any other symptoms present or for information able to be given. All cases of severe or continued diarrhoea should be brought 130 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY under the care of a medical officer. In case the diarrhoea is due to overeating, with consequent absorption of the products of intestinal putrefaction, adminis- ter a brisk cathartic to get rid of the offending material. Hiccough.—Hiccough usually is due to overeating and indigestion. It is caused by spasmodic contractions of the diaphragm, the great muscle which separates the chest from the abdomen. This is the reason that holding the breath as long as possible usually will cure this condition, as the air in the chest forces the diaphragm down so that it does not contract. Drinking a large glass of water in small sips while holding the breath has exactly the same effect. A sudden fright occasionally stops a hiccough, because it causes the patient to take a long breath. If none of these methods are successful, removal of the irritating material from the stomach by vomiting almost always will cure the hiccough. It may, however, be due to some constitutional disease, such as Bright’s disease, and persistent cases should be brought under the care of a medical officer. Convulsions.—Convulsions are most commonly due to epilepsy, hysteria, and various kinds of poisoning. The treatment consists in summoning a medical officer, keeping the patient from biting the tongue or inflicting other injury, and finding out all one can to ascertain the cause. Earache.—Earache may be due to a diseased molar tooth, to beginning mumps, to a stoppage of the Eustachian tube from an inflammation of the throat, and from inflammation or abscess of the external auditory canal, of the ear drum or of the middle ear. In treating examine the teeth and if there is a molar tooth diseased on the affected side, treat it as described in the section on Emergency Dental Treatment. Examine the throat, and if it is inflamed treat it as described under Sore Throat. Examine for begin- ning mumps by feeling back of the angle of the jaw for tenderness and swell- ing and put a very little diluted acetic acid on the back of the tongue to see whether it causes pain and aching in that locality. Pull the ear upward and backward and see if there is swelling and redness in the external audi- tory canal; if so, the earache is due to inflammation there or in the middle ear. Inflammation of the middle ear is dangerous, owing to the possibility of extension of the process into the mastoid cells and from there to the brain unless prompt surgical attention is given. If the earache is due to inflamma- tion of the middle ear, get the patient under the care of a surgeon as soon as possible, as the ear drum probably will have to be incised. In the mean- time, for inflammation of the external auditory canal or middle ear, put the patient to bed with hot applications or a hot-water bottle on the af- fected ear. Chills.—Chills may be simply the result of overexposure to cold and wet, or may be the forerunner of pneumonia, or part of an attack of malarial fever or other disease. Always watch the patient with a chill for other symptoms during and after the chills. The immediate treatment consists of putting the patient in bed between hot blankets, using hot-water bags, and giving hot drinks. Sore throat.—Sore throat may be one of the symptoms in quite a large number of diseases, particularly ordinary tonsillitis, diphtheria, scarlet fever, Vincent’s infection, and syphilis. Always have these diseases in mind in a case of sore throat, and never fail to examine the throat thoroughly in all cases. If a membrane is present in the throat, the case may be one of ordi- nary tonsillitis, of diphtheria, or of scarlet fever. If ulcers are present on the throat, syphilis may be the cause. A good treatment for an ordinary sore throat is to give a brisk cathartic, have the patient gargle his throat BANDAGES AND BANDAGING 131 every hour with Dobell’s solution or diluted vinegar. When possible, always make a smear and stain from the throat of a case of tonsillitis and examine for diphtheria organisms. When in doubt about a case, isolate it and bring it under the care of a medical officer as soon as possible. Modern Surgery.—Da Costa. Traumatic Surgery.—Moorhead. The Treatment of Injuries.—Owen. Accidents and Emergencies.—Dulles. Operative Surgery.—Binnie. References Section 2.—BANDAGES AND BANDAGING Bandages are employed to hold dressings applied to the surface of the body, to secure splints in the treatment of fractures and dislocations, to create pres- sure, to immobilize joints, and to correct deformity. Various materials are employed in making bandages, such as gauze, flannel, crinoline, muslin, linen, rubber, and elastic webbing. Gauze frequently is used because it is light, soft, thin, porous, readily adjusted and easily applied. Flan- nel, being soft and elastic, may be applied smoothly and evenly, and as it absorbs moisture and maintains body heat, is very useful for certain conditions. Crinoline, rather than gauze, is used in making plaster of Paris bandages, as the mesh of the crinoline holds the plaster more satisfactorily than gauze. Muslin is employed in making bandages because it is inexpensive and readily obtainable. It should be soaked in water to cause shrinkage, dried, and finally ironed to remove wrinkles. A large piece of this material easily may be torn into strips of the desired width. Rubber and elastic webbing are used to afford firm support to a part. The webbing is preferable to the pure rubber bandage, as it permits the evaporation of moisture. It is of the greatest importance that a hospital corpsman should become familiar with the general rules of bandaging and profiicient in the application of the various types of bandages. The comfort of a patient, the security of the dressing, and the professional reputation of hospital corpsmen depend upon the proper application of a bandage. A neatly and properly applied bandage is an indication that the dressing covered by the bandage has been properly performed. An untidy, uncomfortable, insecure, improperly applied bandage reasonably may lead one to suspect that the underlying dressing is of the same character and can result only in adverse criticism. Various types of bandages, commonly used, are the roller bandage, the trian- gular bandage, and the many-tailed bandage. The roller bandage is made from one of the afore-mentioned materials, the width and length depending upon the part to be bandaged. For convenience and ease of application, the strip of material is rolled into the form of a cylin- der. Each bandage of this type should consist of only one piece, free from wrinkles, seams, selvage, and any imperfections that may cause discomfort to the patient. Although there are various types of mechanical appliances used in winding bandages, it is essential that hospital corpsmen should be able to roll a bandage by hand. The strips of bandage material should be folded at one extremity several times to form a small, firm cylinder. This cylinder is held by its extremities with the index finger and thumb of the left hand. The free end of the band- age is held between the index finger and thumb of the right hand, close to the 132 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY cylinder. With this hand the bandage then is revolved around the cylinder, which is held in the left hand, the free fingers of which aid in turning the cylindrical roll. The amount of tension exerted upon the free end will deter- mine the firmness of the completed roller. A roller bandage consists of the free end or initial extremity, the body, and the terminal extremity in the center of the cylinder. The length and width of bandages vary according to the purposes for which they are employed. The sizes most frequently used are: 1 inch wide, 3 yards long, for the hand, fingers, and toes; 2 inches wide, 6 yards long, for head band- ages ; 2y2 inches wide, 7 yards long, for extremities; 3 inches wide, 9 yards long, for thigh, groin, and trunk. GENERAL RULES FOR BANDAGING In applying a roller bandage tbe roll should be held in the right hand so that the loose end is on the bottom; the outside surface of the loose or initial end is next applied to and held on the part by the left hand; and the roll is then passed around the part by the right hand, which controls the tension and application of the bandage. Two or three of the initial turns of a roller bandage should over-lie each other in order to secure the bandage and keep it in place. In applying the turns of the bandage it is often necessary to trans- fer the roll from one hand to the other. Bandages should be applied evenly, firmly, and not too tightly. Excessive pressure may cause interference with the circulation and may lead to disastrous consequences. In bandaging an extremity it is therefore advisable to leave the fingers or toes exposed in order that the circulation of these parts may be readily observed. It is likewise safer to apply a large number of turns of a bandage rather than to depend upon a few too-firmly-applied turns to secure a splint or dressing. In applying a wet bandage, or one that may become wet in holding a wet dressing in place, it is necessary to allow for shrinkage. The turns of a band- age should completely cover the skin, as any uncovered areas of skin may become pinched between the turns, with resulting discomfort. Bandages should be applied in such a manner that skin surfaces are not brought in contact, as perspiration will cause excoriation and maceration of the skin. In bandaging an extremity it is advisable to include the whole member (arm and hand, leg and foot), excepting the fingers and toes, in order that uniform pressure may be maintained throughout. It is also desirable in bandaging a limb that the part be placed in the position it will occupy when the dressing is finally completed, as variations in flexion or extension of the part will cause changes in the pressure of certain parts of the bandage. The initial turns of a bandage of an extremity (including spica bandages of the hip and shoulder) always should be applied securely, and, when possible, around the part of the limb that has the smallest circumference. Thus in bandaging the arm or hand the initial turns usually are applied aroiind the wrist, and in bandaging the leg or foot the initial turns hre applied immediately above the ankle. The final turns of a completed bandage usually are secured in the same manner as are the initial turns, by the employment of two or more overlying circular turns. As both edges of the final circular turn are necessarily ex- posed, they should be folded under to present a neat, cufflike appearance. The terminal end of the completed bandage is turned under and secured to the final turns by either a safety pin or adhesive tape. When these are not avail- BANDAGES AND BANDAGING 133 able, the end of the bandage may be split lengthwise for several inches, and the two resulting tails secured around the part by tying. When the turns of a bandage cross each other, as in the figure-of-eight, the spiral reverse, and the spica, the line of crossings should be straight, and if practicable, should be in the center line of the part bandaged, but the line of crossings should not be over a bony prominence. The exposed portions of the turns should be of approximately the same width. In removing a bandage, it may be cut, preferably with bandage scissors. In doing so the operator should be careful to avoid interference with the underlying dressing and the affected area. If the bandage is removed without cutting, its folds should be gathered up in first one hand and then the other as the bandage is unwound. This procedure will facilitate removal and the rewinding of the bandage, if that be desirable. APPLICATION OF BANDAGES AND THEIR USES Circular bandage.—After anchoring the initial turns of the bandage, as de- scribed in a previous paragraph, a series of circular turns is made around the part. Each turn should overlie accurately the turn beneath it, neither ascend- ing nor descending. Uses: Retention of dressings to a limited portion of an extremity, the neck, or the head; compression to control venous haemorrhage and to promote venous stasis. Spiral bandage.—After anchoring the initial turns, each turn is applied in a spiral direction in such a manner as to overlie one-third of the preceding turn. As usually applied to an extremity the upper edge of each turn of an ascending spiral is tighter than the lower edge with resulting Inequality of pressure. For this reason many surgeons object to its use on an extremity. However, this apparent fault may be overcome to a great extent by applying the bandage in the manner described in a preceding paragraph. Uses: Retention of dressings of the arm, chest, and abdomen (fig. 65). Oblique bandage.-—A series of ob- lique turns is applied around a part in such a manner as to have an uncov- ered area between turns. The width of the uncovered area should be uni- form throughout. Uses: Retention of thick dressings or of temporary dress- ings which require frequent removal. Recurrent bandage.—In applying this bandage, the roller, after securing the primary turns, is carried com- pletely over a part to a point opposite its origin, and then reflected and brought back to the starting point, where it is secured by one or more cir- cular turns (fig. 66). In the recurrent bandage of the hand, the bandage is secured at the wrist, carried over the back of the hand, around the tips of the fingers, across the palm to the wrist. Held at this point by the disengaged hand of the operator, the bandage is carried across the palm around the tips of the fingers, across the back of the hand to the wrist, where it is held by the thumb of the opera- tor’s disengaged hand. Each turn overlies one-third of the preceding turn. FlGDRE 66-~TRecur' rent bandage of stump. (Whar- ton.) Figure 65.—Spiral bandage. (Owen.) 134 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The original turn over the fingers may cover the middle and ring fingers, with each succeeding turn applied alternately over the other fingers first to one side and then to the other of the middle finger; or the original turn over the fingers may be applied over the first finger or over the little finger, each subsequent turn covering a portion of the remaining exposed fingers. The reflected portion of the bandage at the wrist is then secured by a number of circular turns. It is customary to complete such a bandage with a figure-of-eight bandage enclos- ing the entire hand. Figure-of-eight bandage.—This is undoubtedly the most useful bandage and with its various modifications, probably is employed more frequently than any other bandage. The hospital corpsman should perfect himself in the applica- tion of this bandage, as, with a few exceptions, the majority of bandages are applied on the principle of the figure-of-eight. Its name is derived from the fact that the turns are applied so as to form a figure 8. Although it is em- ployed commonly in bandages of the joints (elbow, knee, and ankle), it fre- quently is applied in bandaging the neck and axilla, the head and neck, and the head and jaw (Barton). If properly applied, it may be used very successfully in bandaging the extremities. Figure-of-eight of hand and wrist.—After anchoring the bandage with two circular turns about the wrist the bandage is carried across the back of the hand to the base of the fingers, then into the palm, across the palm to the back of the hand, and across the back of the hand to the starting point at the wrist, where one circular turn is made. This general course is followed with several similar turns, each one overlying about one-third of the preceding turn on the back of the hand. After a sufficient number of turns has been made, the bandage is terminated with a circular turn around the wrist. Uses: Retention of dressings on the back of the hand or in the palm (fig. 67). Figure-of-eight of forearm.—This bandage may be the continuation of the figure-of-eight of the wrist and hand, or may be started with primary circular turns of the wrist. The bandage is car- ried obliquely upward across the back of the forearm and around the arm in its natural course, where it forms the upper loop of the figure-of-eight. The bandage then is carried in an oblique direction downward, across the back of the arm, where it crosses the upward turn of the bandage. Then it is carried around the lower end of the forearm to complete the lower loop of the figure-of-eight. The same process is re- peated several times until the elbow is reached, each turn overlapping the upper one-half or three-quarters of the preceding turn. The bandage is terminated finally with two or more circular turns at the elbow. The final circular turn, with both upper and lower edges of the bandage folded under, should be applied firmly and should present a neat cufflike appearance at the upper end of the completed bandage (fig. 67). During the application of this bandage there is always considerable slack in one edge of the bandage where it is carried around the arm. As the bandaging proceeds, however, these loose edges are covered by the ascending turns of the bandage. Uses: Retention of dressings and covering of splints. Figure 67.—Figure-of-eight bandage. (Wharton, modified.) BANDAGES AND BANDAGING 135 Spiral reverse bandage of the arm.—This bandage is in reality a modification of the figure-of-eight, in that only the lower loop or one-half of the figure-of- eight is completed. After anchoring the primary turns, the bandage is carried obliquely upward on the back of the arm. When this turn reaches the center line of the arm, the thumb of the disen- gaged (usually the left) hand is placed upon the body of the bandage to hold it securely in place upon the arm. The operator then unrolls about 5 or 6 inches of bandage which is held slack and is folded upon itself by changing the posi- tion of the hand holding the roller from supination to pronation. The band- age then is carried obliquely downward across the arm to a point opposite that from which the ascending turn started. It then is tightened slightly to conform to the part accurately, then is carried around the limb and the procedure is repeated. It is necessary to retain the thumb upon the point of reverse until the succeeding turn reaches that point. As in the figure-of-eight, each turn should overlie at least one-third of the preceding turn, and the reverses should be in a straight line (fig. 68). Complete bandage of the hand.—After securing the initial turns around the wrist, a recurrent bandage of the hand is applied. The bandage then is carried obliquely across the back of the hand to the tip of the index finger. A circular turn is made around the ends of the fingers. The fingers and hand then are covered by a figure-of-eight or spiral reverse bandage, which finally is com- pleted by two or more circular turns around the wrist. This bandage may or may not be applied to include the thumb. Uses: Retention of dressings of the hand (fig. 69). Demigauntlet bandage.— Using a 1-inch bandage, secure the initial turns at the wrist and carry the bandage across the back of the hand to the base of the thumb, around the thumb, across the back of the hand to the wrist, where a circular turn is made. The same proce- dure is repeated succes- sively for each finger and the bandage finally terminated with a circular turn around the wrist. Uses: Retention of dressings on back of hand (fig. 70). Gauntlet bandage.—The demigauntlet bandage may be extended to include the entire thumb and fingers with either simple spiral turns or spiral reverse turns of each digit (fig. 71). Figure-of-eight bandage of the elbow.—With the elbow in the desired posi- tion, the initial end is secured by circular turns around the forearm just below the elbow. The bandage then is carried upward over the flexure of the elbow Figure 68.—Spiral reverse. (Eliason.) Figure 69.— Complete bandage of hand. (Wharton.) igure 71.— Gauntlet bandage of hand. (Whar- ton.) Figure 7 0.—Demi- gaunlet of hand. (Wharton.) 136 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY in an oblique direction and passed around the arm just above the elbow, where a circular turn is made, and then is carried obliquely downward across the flexure and passed around the forearm. This procedure is repeated, with each turn overlying the preceding turn, the turns on the forearm ascending and those on the arm descending until the entire joint is covered. The final turn is a circular one around the elbow joint itself. This bandage may be started with a circular turn around the joint followed by figure-of-eight turns covering the upper part of the forearm and the lower part of the arm. Uses; Retention of dressings around the elbow joint. Spica bandage of right shoulder (ascending).—After securing the initial end by two circular turns around the arm opposite the axillary fold, the bandage is carried diagonally across the arm and front of the chest to the axilla of the opposite side, then around the back of the chest, across the arm, and across the upward turn to the point of origin. After- carrying the bandage around the arm, this procedure is repeated, each turn over- lying about two-thirds of the preceding turn until the entire shoulder is covered. The turn should cross in a straight line extending up the center line of the arm over the point of the shoulder. Likewise the turns across the chest and back should overlap each other uniformly, and the turns in the opposite axilla should overlap each other exactly. The bandage may be secured by either a pin or adhesive tape. Uses: Retention of dressings of shoulder and axilla and of shoulder cap (fig. 72). Bandages of the lower extremity.—The bandages described in the preceding paragraphs may be applied to the corresponding parts of the lower extremity. However, a description of a few of the special bandages of the lower extremity is considered advisable. Spica bandage of the groin (ascending).—After securing the initial turns around the upper part of the thigh just below the groin, the bandage is carried obliquely upward across the lower abdomen to the iliac crest of the opposite side, transversely across the back and then downward obliquely across the front of the thigh, across the upward turn of the bandage and around the thigh to the point of origin, thus completing a figure-of-eight. This is repeated several times until the entire groin is covered, each turn overlying about two-thirds of the preceding turn. The same care in regard to the line of crossings of the turns and to the uniform overlapping of the bandage on the abdomen should be observed, as is noted in the description of the spica bandage of the shoulder. Uses: Retention of dress- ings in region of the groin (fig. 73). Spica bandage of the foot.—The initial end is secured by two circular turns around the leg just above the ankle. The bandage then is carried across the dorsum of the foot to the base of the toes where a circular turn is made around the foot. After two or three spiral reverse turns are made the bandage is carried across the dorsum of the foot, backward alongside of the Figure 72.—Spica of the shoulder. Spica loops of the shoulder. (Eliason.) Figcse 73.-—Ascending spica ; descend- ing spica. (Bliason.) BANDAGES AND BANDAGING 137 heel, around the heel, forward along the other side of the heel across the pre- ceding upward turn on the dorsum of the foot, and around the foot to the starting point of the turn. This process is repeated, the turns gradually ascending on both the foot and the heel, the crossings of bandage being in the midline of the dorsum of the foot. The bandage finally is carried upward around the ankle and secured by two or more circular turns at its original starting point. It is possible to apply this bandage without the use of the spiral reverse turns by employing the figure-of-eight throughout. Uses: Re- tention of dressings on the foot and support for sprained ankle (fig. 74). Bandage of foot, not covering the heel (French).—After securing the initial end by two circular turns around the leg just above the ankle the bandage is carried obliquely across the dorsum of the foot to the base of the toes, where a circular turn is made around the foot. The bandage is carried up the foot by a few spiral reverse turns crossings in the center line, and then applied as a figure-of-eight around the ankle and instep. The bandage may be terminated just above the ankle or be extended up the leg as far as may be necessary. It is frequently practicable to apply this bandage without employing the spiral reverse turns, the figures-of-eight being applied following the circular turns at the base of the toes. Uses: Retention of dressings of foot. This bandage usually is employed in application of bandages covering the entire leg. Figure 74.—Spica of the foot (first step) ; spica of the foot (completed). (Eliason.) Special bandages. Velpeau bandage.—The fingers of the affected side are placed upon the opposite shoulder, a pad placed in the axilla, and the skin surfaces separated by sheet wadding. Place the initial end of the bandage on the shoidder blade of the sound side, carry the bandage across the outer portion of the affected shoulder, downward over the outer and posterior surface of the flexed arm, behind the point of the el- bow, obliquely across the back of the forearm and chest to the opposite axilla, and around to the point of origin. After repeating this turn once the bandage is carried from the point of origin across the back and side of chest, in front of the flexed elbow and transversely across the front of the chest. Then it is carried around the other side of the chest, diagonally across the back to the affected shoul- der. The first turn then is repeated, followed by a second circular turn around the chest and flexed arm. Each vertical turn over the shoulder overlaps two- thirds of the preceding turn, ascending from the outer part of the shoulder to the neck and from the upper posterior surface of the arm inward toward the point of the elbow. Each transverse turn also overlies one-third of the preceding turn. These transverse turns are continued until the last turn covers the wrist. Figure 75.—Vel- peau (start). (Eliason.) Figure 76.—Velpeau (posterior view). (Eliason.) 138 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The bandage is finally secured with pins, both where it ends and at various points where the turns of the bandage cross each other. (The initial turns of this bandage may be secured by circular turns around the chest under the arm of the affected side.) Uses: Fixation of arm in treatment of fractured clavicle and fixation of humerus after reduction of dislocated shoulder joint (figs. 75, 76, 77). Barton bandage.—With the initial end of the bandage applied to the head just behind the right mastoid process the bandage is carried under the bony prominence at the back of the head, upward and forward back of the left ear, obliquely across the top of the head, downward in front of the right ear, under the chin, upward in front of left ear, obliquely across the top of the head, crossing the first turn in the midline of the head, thence backward and downward to the point of origin behind the right mastoid. Then it is carried around the back of the head under the left ear, around the front of the chin, under the right ear to the point of origin. This procedure is repeated several times, each turn exactly overlying the preceding turn. The bandage is secured with a pin or strip of adhesive tape, and either a pin or adhesive may be applied at the crossing on top of the head. Uses: Fracture of lower jaw; retention of dressings of chin (fig. 78). Recurrent bandage of head.—The initial turns are applied around the head, passing around the nape of the neck, above each ear and around the forehead. When the bandage has reached the center of the forehead on the third turn, its free margin is held by a finger of the left hand and the bandage is reversed and carried over the top of the head in the center line to the nape of the neck. With an assistant holding the bandage at the latter point, it is re- flected forward over the top of the head covering i he right half of i he pre- ceding turn. When it reaches the forehead in the midline it again is reflected over the top of the head, overlying the left half of the first turn. At the nape of the neck in the center line it is again reflected and carried forward overlying the outer half of the second turn. This process is repeated until the entire head is covered, the turns alternating to the right and left of the center line. The bandage finally is completed by several circular turns overlying the original turns and fixing the ends of antero- posterior turns at the nape of the neck and on the fore- head, where pins should be applied to provide additional security. Uses: Reten- tion of dressings of wounds of the scalp, of fractures and operative wounds of the skull (fig. 79). (This bandage may be applied with the turns over the head in a transverse direction extending from ear to ear. Figure 77.—Velpeau bandage. (Wharton.) Figure 78.—Barton bandage. (Wharton.) Figure 79.—Recurrent turns. (Eliason.) BANDAGES AND BANDAGING 139 Crossed bandage of one eye.—The initial extremity is secured by a circular turn around the head below the bony prominence at the back, above both ears and across the forehead. The bandage then is carried from the back of the head, below the ear, obliquely across the outer part of the cheek to the base of the nose at its junction with the forehead, over the opposite side of the head and downward behind the mastoid process. A circular turn then is carried around the head, overlying exactly the original turns. A second turn under the ear and across the face and head then is applied, overlapping the upper two-thirds of the preceding turn. These alternating turns are repeated until the eye (and if more comfortable, the ear on the same side) is completely covered. The bandage is completed with a final circular turn around the head. Uses: Retention of dressings of the eye (fig. 80). Crossed bandage of both eyes.—The initial turns are applied as for one eye, and the bandage carried forward below the right ear, diagonally upward across the cheek to the base of the nose and over the opposite side of the head above the left ear, and downward behind the left mastoid process. Then a circular turn is applied. When the roller reaches the back of the head below the bony prominence it is carried obliquely forward and slightly upward over the right ear across the forehead and downward over the left eye, the lower margin of the bandage crossing the previous turn at the junction of the nose with the forehead. The bandage then is carried across the left cheek below the left ear and backward to the nape of the neck. Then a circular turn is made, followed by a repetition of the previous turns across the eyes, each circular turn accurately covering its predecessor and each oblique turn overlying the upper one-half of the preceding turn, until both eyes are completely covered. The ears may or may not be included in the bandage, which is completed by two circular turns around the head. Pins are placed at the intersections of the bandage (fig. 80). Sayre’s dressing.—This consists of two strips of adhesive plaster 3 inches wide and 2 yards long. Two circular turns of a flannel bandage 4 inches wide are applied to the arm of the affected side just below the axillary fold. The end of one adhesive strip is looped around the arm (overlying the flannel bandage) and pinned, with the loop sufficiently large not to constrict the arm. With the arm drawn upward and backward, the strip of plaster is carried across the back and around the opposite side of the chest. It may end here or be carried com- pletely around the chest. The hand of the injured side now is placed as near as pos- sible to the shoulder of the sound side, the skin surfaces being separated by sheet wadding. The end of the second strip is applied over the scapula of the affected side (some surgeons start this strip at the top of the posterior surface of the arm of the affected side; Figure 80.—Crossed bandage (figure-of- eight) of the eye; crossed bandage of both eyes. (Eliason.) Figure 81.—Sayre’s dressing for fracture of the clavicle, showing application of first and second strips. (Wharton.) 154294°—39 10 140 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY others apply the initial end of this strip on the shoulder of the sound side) and is carried downward on the posterior surface of the arm of the affected side, under the point of the elbow, diagonally across the chest on the posterior surface of the forearm and hand over the sound shoulder down the back where it joins the first strip of plaster. A small hole is cut in this strip to receive the point of the elbow, which must be protected by a layer of cotton or sheet wadding. Then the entire dressing is covered with a Velpeau ban- dage. Uses; Treatment of fractures of the clavicle (fig. 81). “T” bandage.—This bandage consists of a horizontal bandage to which is attached, about its middle, a vertical bandage of approximately one-half the length of the horizontal bandage. The horizontal portion is employed to secure the bandage to the body, the vertical portion being used to retain dressings. This bandage is very useful in retaining dressings about the perineum and anal region. When used for this purpose, the horizontal band is applied around the abdomen above the iliac crests, in such a manner that the vertical portion is placed exactly in the midline of the back directly over the spine. The vertical portion then is brought forward between the thighs and secured to the hori- zontal portion in front of the abdomen. The vertical portion may be split longitudinally to form two strips of equal width. Double “T” bandage.-—This differs from the foregoing in having two vertical strips instead of only one. The horizontal portion may be of any desired width. It frequently is used for the retention of dressings of the chest, breast, and abdomen. When so employed the two vertical strips are carried over the shoulders from the back to the front and secured by pins to the horizontal portion. Many-tailed bandage.—The four-tailed bandage readily is made by splitting a strip of muslin or other material of the desired width, lengthwise, within a few inches of the center of the strip. This provides a bandage with a body and four tails. The many-tailed bandage is prepared in a similar manner, by splitting the muslin or other material into several strips, having a sufficiently large area in the center for the retention of dressings, etc. The number of tails on each side should be the same. Plaster of Paris bandage.—These bandages are prepared by impregnating the meshes of crinoline with plaster of Paris of the extra calcined, dental variety, A strip of crinoline about 3 or 4 inches wide, and usually 4 or 5 yards long, is placed on a table. Plaster of Paris then is dusted upon the strip, and evenly rubbed into the meshes of the fabric. A very satisfactory method of preparing this bandage is by constructing a wooden box, 12 inches long, 6 inches wide, and 3 inches deep, and at each end, just above the bottom of the box, cutting a slit 5 inches long and one-eighth to one-fourth inch wide. The end of the bandage is drawn into the box through one slit, across the bottom of the box, and out of the box through the other slit. A sufficient quantity of the plaster of Paris to cover the bandage with a layer of powder 1 inch deep is placed in the box. As the bandage is drawn through plaster of Paris is rubbed into the meshes with the hand or preferably with a smooth piece of wood approximately 4 inches in length. The bandage may be loosely rolled into a cylinder as it emerges from the box. If the bandages are not to be used within a few hours they should be wrapped in paper to prevent absorption of moisture. Application of the plaster of Paris bandage.—The part to be encased in plaster of Paris should be covered with a suitable bandage of soft material, preferably flannel. The bony prominences should be well protected with cotton. Care should be taken to remove all creases in the dressing and bandage. BANDAGES AND BANDAGING 141 Two rolls of the plaster of Paris bandage are placed in warm water. When bubbles cease to arise from the bandage one roll is removed from the water, the excess water being expressed by grasping the roll at its two ends and exerting pressure with the hands. This method prevents the loss of a consid- erable amount of plaster through the ends of the roll. {Note.—As soon as a bandage is removed from the water replace it with another bandage.) The bandage should be applied rapidly and evenly to the limb. No special form of bandage is necessary as it is sufficient that the part be properly cov- ered. The second bandage is applied as soon as the first has been completed. During the application of the bandage it should be rubbed with the hands in order to provide a smooth even surface. It also is desirable to rub some loose plaster into the dressing. When the final roller has been applied the surface of the completed dressing should be rubbed evenly with liquid plaster prepared by addition of water to dry plaster until it has the consistency of thick cream. In many cases, such as compound fractures, it is frequently necessary to provide access to certain areas of the encased limb. After the bandage has partially set a “window” or trap may be cut in the bandage over the desired area. Removal of a plaster of Paris bandage may be accomplished with the aid of a plaster saw. If none is available the plaster may be softened with a small amount of peroxide of hydrogen, hydrochloric acid, or vinegar, and then may be cut with a knife. Uses: Fixation of fractures; ambulant treatment of fractures; fixation and treatment of injuries and diseases of joints. Starched bandage.—This bandage may be obtained already prepared or it may be prepared in the following manner: Starch is mixed with cold water until a thin, creamy mixture results. This is heated to form a clear muci- laginous liquid. The part should be covered with a flannel bandage over which a gauze bandage is applied. The starch then is rubbed evenly into the meshes of the material. A second gauze bandage is applied and again treated with the starch mixture. This may be repeated until the desired thickness of the bandage is obtained. Bandages impregnated with starch may be moistened and applied wet to a part. This type of bandage is occasionally useful in the treatment of sprains of the thumb or fingers. Triangular bandage.—This bandage, also known as the handkerchief bandage, is used for the temporary or permanent dressing of wounds, fractures, disloca- tions, etc., and for slings. It is very valuable in first-aid work as it is quickly and easily applied, stays on well, and can be improvised from any kind of cloth, as a piece of a shirt, an old sheet, a large handkerchief such as the Navy-uniform neckerchief, etc. Unbleached muslin is generally used in making triangular bandages although linen, woolen, silk, etc,, will answer the purpose. In making them a square of material about 3 by 3 feet or slightly more is folded diagonally to make one bandage or may be cut along the fold to make two bandages. The long side of the triangle is called the t>ase, the point opposite the base is called the apex, and the points at each end of the base are called the ends or extremities. These bandages may be used either as a triangle or as a cravat, the latter being made from the triangle by bringing the apex to the base and folding it upon itself a sufficient number of times to obtain the width desired (fig. 82). The names of these bandages indicate the part of the body to which the base is applied, the location'of the apex, and the shape. For example, in the fronto-occipital triangle the base of a triangular bandage is 142 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY applied to the forehead and the apex is carried to the occiput, and in the mento-vertico-occipital cravat the middle of the base is placed under the chin and the ends carried over the vertex of the skull to the occiput. A few of the more commonly used triangular bandages will now be described. Figure 82.—Folding cravat from triangle. Fronto-occipital triangle.—Place the middle of the base of the triangle on the forehead so that the edge is just above the eyebrows and bring the apex back- ward over the head, allowing it to drop over the occiput. Bring the ends of the triangle around to the back of the head, above the ears, cross them over the apex at the occiput, and carry them around to the forehead and there tie them in a square knot. Finally, turn up the apex toward the top of the head and pin with a safety pin, or turn up the apex and tuck it in behind the crossed part of the bandage. Uses: To retain dressings on the forehead or scalp (fig. 83). Triangle of chest or hack.—Drop the apex of the triangle over the shoulder on the injured side and bring the bandage down over the chest (or back) to the level desired and so that the middle of the base is directly below the shoulder. Carry the ends around the body and tie in a square knot on the back. Finally, bring the apex down on the back (or chest) and tie it in a square knot to one of the ends. Uses: To retain dressings on burns or wounds of the chest or back (fig. 84). BANDAGES AND BANDAGING 143 Brachio-cervical triangle, or arm sling.—The arm to be put in the sling should first be bent at the elbow so that the little finger is about a hand’s breadth above the level of the elbow. Drop one end of the triangle over the shoulder on the uninjured side and let the bandage hang down over the chest with the base Figure 83.—Fronto-occipital triangle. (First-aid Textbook, A. E. C., modified.) toward the hand and the apex toward the elbow. Slip the bandage between the body and the arm, carry the lower end up over the shoulder on the injured side and tie the two ends together at either side of the neck, using a square knot. Draw the apex of the bandage toward the elbow until it is snug, bring it around the elbow to the front, and after folding back a little fasten it to the front of the bandage with a safety pin. The lower end of the bandage may be passed between the arm and the body and under instead of over the injured 144 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY shoulder before tying to the other end. The ends of the fingers should extend slightly beyond the base of the triangle (fig. 85). Triangle of hand.—Place the middle of the base of the triangle well up on the palmar surface of the wrist, carry the apex around the ends of the fingers Figure 84.—Triangle of chest or back. (First-aid Textbook, A. R. C., modified.) and over the dorsum of the hand to the wrist or forearm, fold each half of the part at the sides of the hand back toward the opposite side of the wrist, cross the ends around the wrist and tie in a square knot. Uses: To retain dressings of considerable size on the hand (fig. 86). Triangle of foot.—Place the middle of the base of the triangle on the ankle well above the heel, carry the apex around the ends of the toes and over the BANDAGES AND BANDAGING 145 dorsum of the foot to the ankle, fold each half of the part at the sides of the foot back toward the opposite side of the ankle, cross the ends around the ankle and tie in a square knot. Uses: To retain dressings of considerable size on the foot (fig. 87). Gluteo-femoral triangle.—To apply this bandage requires two bandages, one a triangle, the other a cravat. First fasten the cravat around the waist. Place Figure 85.—Brachio-cervieal triangle or arm sling and showing lower end passing between arm and body. (First-aid Textbook, A. R. C., modified.) the base of the triangle in the gluteo-femoral fold, and carry the ends around the thigh to the front where they are tied with a square knot. The apex is then carried upward and passed under the cravat around the waist, turned HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Figure 86.—Triangle of hand. (First-aid Textbook, A. R. C., modified.) BANDAGES AND BANDAGING 147 down and fastened to the triangle with a safety pin. Uses: To retain dressings on the buttock or hip (fig. 88). Mento-vertico-occipital cravat.—After making a triangle into a cravat of the proper width, place the middle of the cravat under the chin, carry the ends Figure 87.—Triangle of foot. (First-aid Textbook, A. K. C., modified.) upward in front of each ear to the vertex of the skull crossing them there and continuing downward to the occiput where they are tied in a square knot. Uses; To retain dressings on the chin, cheeks, and scalp, and as a temporary dressing to secure fixation of the parts in fracture or dislocation of the jaw (fig. 89). Figure 88.—Gluteo-femoral triangle. (U. S. Naval Medical School.) Figure 89.—Mento-vertico-occiptal cra- vat. (U. S. Naval Medical School.) Bis-axillary cravat.:—After making a triangle into a cravat of the proper width, place the middle of the cravat in the axilla, carry the ends upward to the top of the shoulder crossing them there and continuing across the back and chest respectively to the opposite axilla where they are tied in a square knot. Uses: To retain dressings in the axilla or on the shoulder (fig. 90). 148 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Cravat of head or ear.—After making a triangle into a cravat of the proper width, place the middle of the cravat over the point desired, carry the ends to the opposite side of the head, cross them, and bring them back to the starting point and tie with a square knot. Use: To apply pressure to control serious haemorrhage from wounds (fig. 91). Figure 90.-—Bis-axillary cravat. (U. S. Naval Medical School.) Figure 91.—Cravat of head or ear. (U. S. Naval Medical School.) References Minor and Operative Surgery, Including Bandaging.—Wharton. Bandages and Bandaging for Nurses.—Cowan. American Red Cross First Aid Textbook. Section 3.—SPLINTS AND APPLIANCES The illustrations and most of the text in this section are taken from the Man- ual of Splints and Appliances of the U. S. Army, and the courtesy of the War Department, Office of the Surgeon General, in permitting the use of that manual is herewith acknowledged. In the foreword to the third edition of the Manual of Splints and Appliances of the U. S. Army it is stated that the number of splints and appliances is confined to as few as possible for adequate treatment and the designs meet the qualifications of efficiency and correct mechanical principles; simplicity of design and low cost of construction; and transportability, so that an efficient splint may be applied and remain in place until the patient reaches the hos- pital for definitive care. Many of the splints and appliances in the Manual have the outstanding advantages of quick manufacture and ease of distribution, the combination of traction and fixation in the same apparatus, and constancy of type and simplicity of mechanical principle, making it readily understood and easily applied. Splints should be applied so as to assure fixation and traction, thereby re- ducing the chances of infection and minimizing the pain and shock during transportation. SPLINTS AND APPLIANCES 149 THE SPLINTING OF FRACTURES FOR TRANSPORTATION The necessity of splinting of fractures before’ transportation is attempted cannot be over-estimated. It lessens pain, shock, and additional damage to bone and soft parts. Compound fractures are not further contaminated, shortening is prevented, and reduction is made less difficult. The primary mortality fate of 50 per cent in compound fractures of the femur in the British Army during the World War was reduced to 15 per cent by proper splinting alone. Every major fracture in the long bones should be splinted “where they lie” before transportation is attempted. The proper splinting of peace-time fractures is equally as essential as the care of war-time injuries. Army hinged half-ring thigh and leg splint.— (Keller leg splint). The side arms of the splint are made of %-inch cold rolled steel or Bessemer steel rod. The half-ring of same material % inch in diameter. Figure 92.—Army hinged half-ring thigh and leg splint (Keller). (U. S. Army.) The half-ring is covered with an inner layer of %-inch felt and an outer layer of %-inch felt. The felt is covered with first-cut horse hide, cream color, not oiled or dressed, and free from material that might irritate the skin. The leather is neatly and securely sewed with waxed linen thread, using a baseball stitch (about four to the inch). The covering is so stitched that the surface coming into contact with the patient is smooth. The finished padded portion is about 1% inches in diameter. The inner layer of felt stops at the joint, being tapered for a distance of about 1% inches just above the joint to allow for the thickness of the webbing strap over which it is sewed. The outer layer of felt stops 1% inches below the joint, the ends being tapered for a distance of approximately 2 inches and cut transversely to permit passage of the webbing strap. The stitching is continuous and is carried through the webbing (fig. 92). 150 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Uses.— Transportation and fixed traction of— 1. Fractures of the femur. 2. Fractures and injuries of the knee. 3. Fractures of the tibia above the ankle Definitive care.—Suspension traction treatment of fractures of— 1. The femur. 2. The tibia and fibula. 3. Other injuries and orthopedic conditions of the lower extremity. Splint strap, adjustable traction. This is accessory to the Army hinged half-ring splint for transportation. The adjustable traction splint strap is made of 1-inch nonelastic webbing. It consists of a main loop, a retention strap with buckle, and an extension strap with swivel. The loop is 14 inches in circumference and is designed to fit over the instep. A 12-inch strap without buckle and a 2%-inch strap Figure 93.—Splint strap, adjustable traction. (U. S. Army.) with a 1-inch chrome-plated nickel-steel release buckle are sewred to the loop in a manner which will retain the loop in proper position across the instep when the 12-inch strap is passed back of the ankle and buckled just posterior to the external malleolus. A 40-inch strap attached to the loop by means of a swivel is provided for the purpose of applying extension (fig. 93). The adjustable traction strap is applied over the shoe of the patient and attached to the lower end of the Army hinged half-ring splint to secure fixed traction. Traction is increased by the Spanish windlass principle. The illustrated ankle hitch or the Collins’ hitch, using a muslin bandage may be used as a substitute (fig. 94). The shoe should never be removed in the field. When clothing has been removed the extremity should be shaved and skin traction applied as shown in figure 108, the rope from the spreader being fixed to the end of the splint to obtain traction. Splint support and foot rest. This appliance (fig. 95) is made of cold rolled steel or Bessemer steel rod and its efficiency depends upon its spring—therefore the rod should be worked cold, as heat will remove the temper. For use two are required. One is attached to the lateral bars of the Army hinged half-ring splint, with the arms of the appliance toward the distal end SPLINTS AND APPLIANCES 151 of the splint after the leg has been fixed in the splint. It supports the distal end of the splint, allowing the leg to be suspended in the splint and not resting oh the ground, litter, or table. A second one is secured in a similar manner with the arms extending upward and to it the foot is secured by a triangular bandage. Figure 95.—Splint support and foot rest. (U. S. Army.) Allow the splint support to rest on the canvas of the litter and secure it to the stirrups of the litter by means of straps or bandages. See figures 96 and 97 for use of this appliance, supported by old-type stretcher bar. Application of immobilization by traction-fixation of major fractures of the lower extremity for transportation. For this purpose the following equipment is required: Army hinged half- ring splint; adjustable traction splint strap; two splint support and foot rests; and five triangular bandages. In the application of the traction-fixation splints for transportation, two men “A” and “B”, work together and carry out the following procedures: 1. “A” grasps and makes traction on the foot of the patient while “B” applies the traction strap or ankle hitch over the shoe. 152 HANDBOOK OF THE HOSPITAL CORPS, U. S. N’AYY 2. While traction is continued by “A”, if the fracture be compound, “B” cuts away clothing about the wound, applies tincture of iodine and then an occlusive dressing (first-aid packet). Figure 96.—Immobilization of fractured femur for transportation. (U. S. Army.) Figure 97.—Immobilization of fractured femur for transportation. (U. S. Army.) SPLINTS AND APPLIANCES 153 3, While traction is continued by “A”, “B” adjusts the Army hinged half- ring splint (right or left), locking the half-ring at a right angle to the bars of the splint, slides the splint in under the leg and secures the ring against the tuberosity of the ischium, tightening the anterior strap to hold it there. 4. “B” secures the traction strap to the end of the splint and increases trac- tion by the Spanish windlass method. “A” lets go his traction on the foot. 5. “A” attaches the splint support to the splint which elevates splint from the ground and assists “B” in securing the extremity to the side bars of the splint, using four or more triangular muslin bandages. 6, “A” attaches the foot support to the splint and ties the foot in position against it, using a triangular bandage. 7. “A” and “B” place the patient on the litter and rest the splint support on the canvas of the litter, securing it to the stirrups of the litter by means of straps or bandages. (If a litter bar is attached to the litter the splint support is locked in the groove on the bar.) Pierson attachment for Army hinged half-ring leg splint. This attachment (fig. 98) is constructed of cold rolled steel or Bessemer steel rod and is U-shaped, 24 to 25 inches long, 6% inches wide at the open end and 4% inches at the other. To each open end is attached a metal hinge, Figure 98.—Pierson attachment for Army hinged half-ring leg splint. (U. S. Army.) freely moveable on the Pierson attachment and which will lock the attach- ment to a fixed place on the Army hinged half-ring splint. Its uses are in supracondylar fractures wThere knee flexion is necessary for the reduction of the fracture in conjunction with skeletal traction, and in suspension-traction treatment of all thigh and leg fractures to allow early knee motion, and in other conditions when traction and knee motion are desired. Splint, Liston long interrupted. This splint (fig. 99) is interchangeable, right and left, and consists essentially of a long member, a short member, a vertical foot piece, and a T-shaped cross member, constructed of ash or other suitable wood, and an offset metal U-shaped member. Dimensions and other details are illustrated in figure 100. 154 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Construction.—The long and short members are jointed together by the offset metal U-shaped member which is fastened thereto by a T-shaped attach- ment upon each side arm. The attachment of this metal member is effected by means of four %-inch head bolts with square nuts. On the inner side of Figure 99.—Liston long, interrupted splint. (U. S. Army.) the splint g’s-inch rectangular reinforcement plates, or suitable washers, are interposed between the wood and the bolt heads. It is important that the cross arm at the top of the splint be secured with four screws as well as glued. Figure 100.—Detailed drawing of Liston long, interrupted splint. (U. S. Army.) Uses.- 1. Fractures of the femur, knee or tibia with injury about the ischial tuberosity so that the half-ring splint cannot be applied. 2. Injury to the pelvis and hip where fixation is required. This splint is reinforced by additional bandages or slings for the support of the leg or thigh when indicated. Additional splinting, using the wire ladder splint or pieces of the basswood splint board, is added as indicated. Splint, wire ladder (fig. 101). Construction.—The frame is made in the form of three sides of a rectangle, 3% by 31 inches, one short side missing, made of No. 9 B&S gauge malleable iron wire. 2. The cross pieces are made of one continuous piece of No. 15 B&S gauge malleable iron wire shaped in the form of a gridiron with parallel bars about % inch apart. SPLINTS AND APPLIANCES 155 3. The gridiron section of wire is attached to the frame by tightly wrapping with a malleable iron wire of about 22 B&S gauge. Three turns to each lateral section and two in between. Ends are well wrapped and secured. 4. Following assembly the splint is heavily galvanized. Figure 101.—Wire ladder splint. (U. S. Army.) Uses.— 1. Splinting for transportation of Pott’s fractures, injuries and frac- tures about the ankle and foot. (Gauze-cotton pads in peace time and first-aid packet, large, in war are used as padding. The splints, when padded and applied, are held in position by a bias muslin bandage.) 2. As coaptation splints in the field or in hospital. 3. Where a malleable light splint is required for a temporary period, as for the shoulder, elbow, or wrist, to maintain a fixed position other than that of extension. Splint, Thomas, arm, hinged, traction. This splint (fig. 102) is made of ti-inch cold rolled or Bessemer steel rod, gray saddle felt, and NS—3 horse hide. The ring is protected with gray saddle felt covered with first-cut horse hide, cream color, not oiled or dressed and free from material that might irritate the skin. The leather is neatly and securely sewed with waxed linen thread, using a baseball stitch (about four to the inch). The covering is so stitched that the surface coming into contact with the patient shall be smooth. The finished padded portion is about 1% inches in diameter. Uses.— 1. Injuries to the shoulder joint. 2. Injuries to the shaft of the humerus. 3. Injuries to the elbow joint. 4. Injuries to the upper one-third of the forearm. 154294°—39 11 156 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY A hitch about the wrist to obtain traction is forbidden. A method of application to the upper extremity, using two persons, “A” and “B” follows: 1. “A” grasps the hand and makes traction. “B” determines site of fracture, removes all clothing to shoulder and if the fracture is compound, iodizes the wound and applies an occlusive dressing. 2. “B” applies adhesive traction to the dorsal and volar surfaces of the arm from the fracture point or above down to the wrist. The adhesive is doubled back on itself over the hand, so that it will not- adhere—2or 3-inch Figure 102.—Thomas hinged, traction arm Splint for right or left arm. (U. S. Army.) adhesive is used and is covered with a gauze bandage to promote adherence. A short piece of light or %-inch braided cotton rope is tied to the end of each of the two adhesive straps. 3. While “A” still makes traction, “B” threads the arm through the ring of the hinged ring traction splint until it rests against the chest wall and shoulder girdle. He then ties the ropes from the adhesive traction straps to the end of the splint. A small sliver of wood is passed between the adhesive straps at the finger tips to prevent tortion of the adhesive on the hand, while “B” increases traction with a second wooden sliver between the ropes by the Spanish windlass method. 4. “A” and “B”’ secure the arm and forearm to the side bars of the splint, using three or more triangular bandages. SPLINTS AND APPLIANCES 157 Figure 103.—Thomas hinged, traction arm splint applied. (U. S. Army.) SPLINTS AND APPLIANCES FOR DEFINITIVE CARE OF BONE AND JOINT INJURIES Balkan Frame Bag, buckshot, 3-inch, holds 1 pound 10 Bag, buckshot, 5-inch, holds 5 pounds 10 Bag, buckshot, 8-inch, holds necessary number of 1- and 5-pound shot bags 5 Buckshot, coarse pounds 50 Clamp, large (Detail C) 10 Clamp, small (Detail D) 10 Hammock for suspension of pelvis, large 1 Hammock, small 1 Poles (Detail A) set— 1 4 feet by 1% by 1 inch 3 6 feet by 1% by 1 inch 5 8 feet by 1% by 1 inch 4 Pulley assemblage (Detail B) 8 Rope, %6-inch, braided cotton, unglazed yards— 30 Details of metal parts and timber are shown in figure 104. Uses.—The Balkan Frame is used for suspension of; Upper extremity; lower extremity; fractures of the pelvis; and the whole body when in plaster, The following material is required for erection and use of a Balkan Frame; 158 HANDBOOK OF THE HOSPITAL, CORPS, U. S. NAVY Figure 104.—Balkan Frame ; details of metal parts and timber. (U. S. Army.) Figure 105.—Balkan Frame; side view. (U. S. Army.) When assembled (fig. 105), the middle over-head pole of the frame from which the leg is suspended is placed parallel with the long axis of the leg. Sufficient weight (1- and 5-pound shot bags) is placed in the open-mouthed bag to balance the weight of the splint and leg. The rope going over the pulley at the head of the bed carries sufficient weight (about 8 pounds) to hold the ring of the splint in position against the ischial tuberosity. SPLINTS AND APPLIANCES 159 Figure 106.—Balkan Frame in use lor fractured femur; thigh in abduction. (U. S. Army.) Figure 107.—Balkan Frame in use for fractured humerus. (U. S. Army.) 160 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Traction is obtained by the use of adhesive plaster through the rope over the pulley at the end of the frame (25 to 30 pounds). The extremity is suspended in the splint by the use of 5-inch canton-flannel bandages as slings, using large safety pins for fixation. Length is obtained by weight and pulley traction, alignment by abduction, adduction, flexion, or extension of the distal end of the splint (distal frag- ment). Alignment is also changed by adjusting the position and tightness of the supporting canton-flannel slings. Figure 106 shows the Balkan Frame in use for an intertrochanteric fracture of the femur treated in extreme abduction, using skin traction. The frame allows any position of abduction or adduction. All four ex- tremities may be suspended at one time or any combination, including a fractured pelvis. The foot of the bed is ordinarily elevated so that the body will better act as a counter weight against traction. If there is a wound in the region of the ischial tuberosity the half-ring of the splint may be reversed to the anterior surface of the thigh and dressings held in place behind by the strap and buckle. A “monkey bar” made of a broom handle and suspended from the frame by rope so that it hangs within reach of the patient is a welcome aid to him in changing his position in bed. Figure 107 shows the Balkan Frame in use for a fracture of the humerus treated by skin traction in abduction. The humerus is suspended in a canvas hammock 8 by 30 inches, with four eyelets above and a piece of board through both of which laces are passed. The forearm and hand are suspended from a wooden spreader, made locally, using four 1-inch steel buckles and sufficient 1-inch nonelastic webbing. A piece of broom stick makes an excellent hand hold. Position of the distal fragment is changed by abducting or adducting the arm and likewise by changing the supporting pole of the suspending frame and by increasing or decreasing the weight attached to the forearm or that attached to the hammock. Skin traction. Application.—The skin is prepared by shaving, cleansing with gasoline and alcohol, and drying. A strip of adhesive is rolled from a 3-inch spool and doubled on itself suffi- ciently so that this double thickness will extend from above the malleolus to the buckle of the spreader. The strip is then cut the length desired. A second strip is likewise prepared. A third strip is split in half to be used as the spiral. The lateral and mesial straps extend upward to the fracture site and are applied and bound by the spiral straps. It is applied evenly, wrinkling being avoided as it produces blisters (fig. 108). The spiral should avoid the peroneal nerve over the neck of the fibula, the suprapatellar bursa, and not be bandaged tightly about the ankle. The leg is then bandaged with a gauze bandage to promote adhesion. For below-knee traction, the adhesive extends only to the knee. The spreader and foot support (fig. 108) are made locally from: Sheet aluminum; Webbing, 1%-inch, gray, nonelastic; Buckle, 1%-inch, two-prong; Wood, 4% by 1% by % inch pine; and necessary Tacks, rivets or screws. The design of the spreader is from the Massachusetts General Hospital. SPLINTS AND APPLIANCES 161 Figure 108.—Skin traction using zinc oxide adhesive. (U. S. Army.) Splint, wire, Cabot posterior leg. A figure approximating but not exactly that of a parallelogram, is constructed of %-inch cold rolled or Bessemer steel rod, with the free ends welded. One end, the welded, will measure inches, the other end 4% inches. The small Figure 109.—Cabot posterior, wire leg splint. (U. S. Army.) end of the frame is bent at a right angle to the plane of the frame 12 inches back from this end. The two sides measure 30 inches. The large end which has been brazed or welded, shall present concavity 2% inches at its center. This splint (fig. 109) is used for immobilization of the knee, ankle, foot, and soft parts of the leg. 162 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Application.—A hammock is formed on which the extremity is supported in the steel frame by wrapping about it, not too tightly, a bias muslin bandage. Additional padding may he added, using gauze and cotton pads as desired. The extremity should at no place rest on the metal bars of the splint. The splint may be bent at the knee to give any amount of flexion desired. The extremity is bound to the splint, using additional muslin bandages. T-splint for fractured clavicle. This splint (fig. HO) is made locally of the following material: Wood, maple or hickory, 3 by 18 inches, 2 pieces; buckles for 1%-inch webbing, 6; felt, saddle, gray; stockinette, 3-inch; webbing, 1%-inch; and necessary carpet tacks, rivets or screws. Figure 110.—T-splint with straps; for fractured clavicle. (U. S. Army.) Construction.—The T is framed by mortising and fixing with rivets or screws the end of one piece of the wood with the middle of the other. Straps and buckles are secured to the wooden T-splint by carpet tacks, as indicated. Padding of saddle-felt covered with stockinette may be sewed to the straps which cause pressure under the axilla and to the abdominal strap, or, gauze cotton pads may be used, being pinned to the straps using safety pins. These dimensions of the T are used for the average patient: Larger, 20-inch, and smaller, 16-inch; splints should be made up and available. For infants and young children T-splints are made from basswood splint board, tacked together, padded, and fixed to the child with bandages and adhesive. Application.—In fractures of the clavicle the shoulder drops downward, for- ward, and inward. The proximal fragment is usually pulled slightly anterior and upward. The splint is padded with saddle felt, or gauze cotton pads, held in place by adhesive. SPLINTS AND APPLIANCES 163 Traction is made upward, outward, and backward on the shoulder to reduce the fracture. The splint is applied to maintain immobilization. The inner strap on each side is brought up under the splint and over the shoulder at the base of the neck of the patient, crossed over the chest and secured to the two upper buckles on the lower end of the vertical arm of the splint. The abdominal strap is applied. Both shoulders are now pulled up- ward, backward, and outward by the axillary strap and fixed in this position. Straps are adjusted daily and skin under splint cared for. Aeroplane or abduction splint. This splint (fig. Ill) is made locally of the following material: Buckles, 1%-inch, two-prong, 3; rod, steel, Bessemer or cold rolled, 12 foot lengths; sheet aluminum, 16-gauge; and webbing, gray, nonelastic. Its measurements are— 1. Width of lower end of splint, average 7 inches, convex curve. 2. Distance from just below anterior superior spine of ilium to anterior axillary fold. 3. Length of arm, measured from anterior axillary fold to flexed elbow, arm in abduction. 4. Length of forearm, measured from flexed elbow to middle of palm of hand. 5. Line across palm, average 3 inches. Figure 111.—Aeroplane or abduction splint. (XL S. Army.) Construction.—The steel rod is bent cold (easily accomplished by use of vise and hammer). The rod is joined and fixed under hand piece by fixing ends of the rod in an aluminum cylinder. The aluminum cylinder is formed from a piece of aluminum % by 2% inches, which is fashioned around a %-inch steel rod using a vise and hammer. Three nonelastic webbing straps and buckles are attached to the splint by sew- ing, as illustrated. 164 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Canvas is sewed over the metal bars of the splint forming a hammock which supports the splint against the pelvis and chest wall and the arm and forearm on the splint. Gauze-cotton pads are added, as indicated. A bias muslin band- age may be used in lieu of canvas. The arm and forearm may be secured to the splint by a bias muslin bandage. Uses.—The aeroplane or abduction splint is used for— 1. Brachial-plexus injuries; 2. Paralysis or weakness of abductor muscles of shoulder; 3. Shoulder-joint injuries (other than dislocation) ; 4. Fractures of the scapula, of the surgical and anatomical necks of the humerus, and convalescent fractures of the shaft of the humerus; 5. Subacromial-bursitis; and 6. Acromio-clavicular dislocations. Splint, basswood. This splint material is used in the splinting of forearm and carpal fractures, and for coaptation splints. When a splint is to be prepared for a Colics’ fracture it should extend from just below the flexed elbow to the metatarsal-phalangeal joints, so as to allow free motion in these joints, and should be cut away over the thenar eminence so as not to produce “flat hand”. Figure 112.—Splinting of lower forearm fractures. (U. S. Army. The good forearm and hand, with hand in ulnar deviation, is placed palm down on a piece of splint board and outlined with pencil as shown in figure 112. The broken line is marked in after hand is removed from board. The posterior splint is marked out in a similar manner. The splints are now cut out from the splint board, using a plaster knife, a pocket knife, or scroll saw, and sufficient layers of sheet wadding are laid on each splint and cut with a pair of bandage scissors to fit the splint. The pad- ding is then secured to the splints with three or more narrow strips of adhesive. In splinting a Colles’ fracture after reduction, two additional pads are formed of sheet wadding. One, the longer of the two, is placed against the proximal EMERGENCY DENTAL TREATMENT 165 fragment and the palmar splint is placed in position. The second and smal- ler pad is placed over the distal fragment and the dorsal splint applied. While the splints are held in position an adhesive strap, 1 to 1% inches wide, is placed around the wrist, to be followed by a second one around the upper end of the splint, and a third around the lower end securing the hand in ulnar deviation. A gauze bandage is then applied. Splints should show a “spring” when compressed by the operator’s hand to insure that they do not bind too tightly. For other forearm fractures splints are applied as in Colies’ fractures, except that ulnar deviation may or may not be desired, and the position and size of the supplemental pads are changed as indicated to maintain reduction of frag- ments. Section 4.—EMERGENCY DENTAL TREATMENT Dental first-aid consists of skilled or semiskilled emergency treatment given to sufferers from disease and accidents involving the dental structures until regular dental care can be given. The treatment here suggested is intended only for the temporary relief of pain in the absence of a dental officer or when treatment facilities are inadequate. The effectiveness of dental first-aid depends upon an accurate diagnosis of the trouble to be treated and upon the correct application of the remedies indicated. All cases receiving dental first-aid should be referred to a dental officer as soon as possible for further treatment. Pain, apart from accidents such as bruises and fractures, is a symptom or expression of some deeper pathological change within the tissues and is evidence of the need for further treatment. The purpose of dental first-aid treatment is to relieve pain, to prevent its recur- rence, and to prevent the development of infection. Hospital corpsmen on independent duty should do all in their power to remedy conditions which later may result in dental emergencies. Quite frequently naval personnel are on types of duty which preclude the possibility of obtain- ing skilled dental treatment within a reasonable length of time. It is for this reason that intelligent forethought should be exercised and the following sug- gestion considered very seriously in the interests of the comfort and welfare of the crew. Personnel of craft of any description for whom it is anticipated dental service will not be available should, prior to departure from a yard or base, have dental examinations and treatment. Until very recently (1936) this advice would have been impracticable on account of the limited number of dental officers in the Navy, but the allowance of these officers has been in- creased and it is now practicable to carry this suggestion into effect to a greater extent than ever before. Health records should be examined to see if they contain up-to-date dental records, and if lacking, these should be supplied. This is most important because it not infrequently happens that dental records fur- nish the only means of identification. Whenever possible officers and men should be sent to a dental officer every 6 months for examination and treatment. Advantage should be taken at isolated stations of the visits of naval or Coast Guard vessels carrying dentists. The services of Army, Public Health, Veterans’ Administration, and Indian Service dental officers may be obtained in cases of emergency. Dental treatment by dentists in civil life may be obtained in accordance with instructions contained in the Manual of the Medical Department. This manual authorizes emergency dental treatment for the relief of pain prior to authoriza- 166 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tion by the Bureau of Medicine and Surgery, but ordinarily prior authorization must be obtained from the bureau. Read the manual, especially when in doubt. Dental first-aid to be effective must be rendered by one who is acquainted with the structural and functional characteristics of the dental tissues. It is therefore absolutely necessary for the hospital corpsman to know the funda- mental facts regarding the teeth and the related tissues. Dental tissues. The word dental is derived from the Latin word dens, meaning tooth. The dental tissues are those involved in the formation and structure of the teeth, and in their support in normal function. They consist of the enamel, dentin, cementum, pulp, peridental membrane, alveoli of the jaws, and gums or gingivae. Deciduous dentition. It is interesting to know that the baby or deciduous teeth begin their forma- tion during foetal life. The crowns of the two upper and two lower deciduous incisors are almost completely formed when the baby is born. There are 20 teeth in a deciduous set, 10 upper and 10 lower. Each jaw has 4 incisors, 2 canines, and 4 molars. While these teeth are being used for mastication the permanent teeth are forming in the jaw just below them. As the crowns of the permanent teeth grow the roots of the baby teeth are resorbed which accounts for the fact that, when shed normally, baby teeth do not have roots. Permanent dentition. There are 32 teeth in the normal permanent set, 16 in each jaw as follows: 4 incisors, 2 canines, 4 premolars or bicuspids, and 6 molars. In the average mouth the third molars often fail to erupt and make their way through the gum and so do not take their normal working occlusion. This does not decrease the efficiency of the masticating organ. Figure 113.—United States Navy method of numbering teeth. In the Navy, for the purpose of uniformity of records, the teeth are num- bered from 1 to 32, beginning with the upper right third molar and continuing to the left side of the upper jaw, the third molar there being number 16, dropping to the lower right third molar for number 17 and continuing around the lower jaw to the left, the third molar there being number 32 (tig. 113). The teeth. Each tooth is usually considered to consist of two main parts, the crown and the root, which are connected by a third, the neck. The crown is that part of a tooth which projects above the gum and is the masticating part of EMERGENCY DENTAL TREATMENT 167 a tooth. The shape of the crown varies in the different teeth and on the masticating surface of the molars and premolars are from two to five rounded prominences called tubercles, or cusps, which are separated by grooves. The neck is the faintly constricted part of a tooth between the crown and the root and it is surrounded, collar-like, by the gum. The root is that part of a tooth which is embedded in the alveolus of the maxillae or mandible, supports the crown, and is designed to withstand the forces of mastication. The end of the root is called the apex and through an opening in it the nerve and blood supply enter the tooth. The number of roots on a tooth varies according to the amount of work done by it in mastication, the molars and premolars, or grinding teeth, therefore having two or three roots while the incisors, or cutting teeth, and the canines have but one. The alveolus is the cavity or socket in the maxillae and the mandible which receives the root or roots of a tooth. It varies in size and depth according to the tooth whose root or roots it contains, and is lined with the peridental membrane which also covers the root. When a tooth is cut in half vertically through the center (fig. 114) a cavity will be found in the crown and center of each root which connects with the opening in the apex. The larger part of this cavity in the crown and neck is called the pulp cavity, the long, slender part in the root is known as the root canal, and both are filled with a soft, loose connective tissue, the dental pulp, which contains the blood vessels and nerves of the tooth. In the molar and premolar teeth the pulp cavity is extended into the bases of the cusps and in the incisor teeth it extends out toward the angles of the crown. In structure, a tooth is composed of both hard and soft tissues, the hard tissues being the enamel, dentin, and cementum and the soft the dental pulp and peridental membrane. Surrounding the neck of the tooth and covering the alveolus is a firm tissue called the gingiva, or gum. Enamel is the white, glistening substance which covers the crown of the tooth and extends to the commencement of the root. It is thickest on the masticating surface of the crown and gradually thins as it approaches the neck where it is slightly overlapped by the cementum. Enamel is the hardest, most compact, and most resistant substance in the body and is composed of “slender, prismatic rods, irregularly five or six sided,” which lie parallel with one another and, generally speaking, at right angles to the junction of the enamel with the dentin, being vertical on the summit of the crown and hori- zontal on the sides. The enamel rods are held together by a cementing sub- stance which, like the rods, is composed of inorganic salts. According to Noyes the chemical composition of enamel is as follows: Calcium phosphate and fluoride 89. 82 Calcium carbonate 1 4. 37 Magnesium phosphate 1. 34 Other salts * . 88 Organic matter 3. 39 Fat . 20 Total 100.00 Per cent Dentin is the hard, yellowish-white substance which composes the greater portion of the tooth and is a modification of osseous tissue but from which it differs in structure. It is highly elastic and very tough, gives strength to the tooth, and consists of the matrix, into which fine fibrils of the dental 168 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Figure 114.—Vertical section of an incisor tooth. 169 EMERGENCY DENTAL TREATMENT pulp extend, and the dentinal tubules which traverse the matrix everywhere, whose walls are called the dentinal sheaths of Newman, and which contain the den- tinal fibers, prolongations of the outermost cells of the dental pulp. Accord- ing to Noyes the chemical composition of dentin is as follows; Per cent Calcium phosphate and fluoride 66. 72 Calcium carbonate 3. 36 Magnesium phosphate 1. 08 Other salts . 83 Organic matter 27. 61 Fat . 40 Total 100.00 Cementum is the outer covering of the root of the tooth and begins as a very thin layer slightly overlapping the enamel at the neck and increasing in thickness as it nears the apex which is composed entirely of this substance. In structure and chemical composition it closely resembles bone and is formed around the root in layers which are deposited one on top of another. To it the fibers of the peridental membrane are attached thereby securing the root in the alveolus. The dental pulp which occupies the pulp cavity and the root canal is com- posed of branched connective tissue cells whose branches anastamose and form a fine network within which is a jelly-like material and the blood vessels and nerves of the tooth. The outermost cells of the dental pulp are known as odontoblasts, whose function is to form dentin and which have processes that are prolonged and extend into the dentinal tubules in the dentin. The func- tion of the nerves in the dental pxdp is largely sensory and they respond to thermal and chemical changes and traumatic irritation. A very rich blood supply is necessary for the normal functioning of the pulp and consequently there are numerous blood vessels in it which form a capillary plexus within the odontoblasts. The peridental membrane, also called the periodontal membrane and alveolar periosteum, is a 1'ayer of fibrous, nonelastic connective tissue which lines the alveo- lus and covers the root of the tooth. It is continuous with the fibrous structure of the gum and its fibers are attached on one side to the cementum of the root and on the other to the bone of the alveolus. The root is thus firmly fixed in the alveolus and may be said to rest in the peridental membrane as if in a ham- mock. It is obvious that the peridental membrane permits a very slight move- ment of the teeth in mastication. When this membrane is diseased the tooth movement becomes excessive and the tooth is loose or feels high. Pain will be experienced when the tooth feels high. The gingiva, or gum, is the soft but firm tissue surrounding the neck of the tooth. It is a dense fibrous tissue continuous with the peridental membrane lining the alveolus and is covered with a smooth and vascular mucous mem- brane. On each tooth there is a shallow trough or crevice which is formed by the free margin of the gum and is called the gingival trough or crevice. The gum is held snugly to the tooth by circular fibers which act as elastic bands, is firm to the touch, and normally is a pale pink in color. Damage done to the gum during a prophylaxis contributes to a breaking down of the tissues composing the gum, and wiien the tone (elastic effect) of the gum is lost, food has a ten- dency to fill the gingival trough. The pressure exerted by the packing of food in the trough, together with the activity of the bacteria incorporated in the food, leads to an inflammatory condition of the gums called gingivitis when 170 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY in the acute stage and pyorrhoea when in an advanced and chronic stage. Another factor of importance in the health of the gum is the hard incrustation of mineral and organic matter which forms on the teeth and sometimes on the gum called tartar or calculus. Tartar is of two kinds, salivary calculus, which forms above the gum, and serumal calculus, which forms below the gum line. If the teeth are not kept free from tartar formation, the gums become inflamed, recede, and are subject to attacks by dangerous organisms. The oral cavity. In considering the mouth from the standpoint of cleanliness, it must be re- membered that more types of bacteria are to be found there than in any other part of the body. In the vernacular it might be said that the mouth is a “club house” for bacteria, as the presence of food, and the air, moisture, and temperature in the mouth make conditions there most favorable for their growth. All bacteria found in the mouth are not harmful to man, and the body’s resist- ance to the invasion of bacteria is its natural protection against these lower forms of life. The harmful bacteria are the ones that are of most interest to the dentist and physician in their practice of the healing arts, and they, as well as the con- ditions they produce, can be recognized. Before any treatment is given the bacteria present should be identified so that measures to combat them may be taken. It is with this thought in mind that the following oral conditions are briefly described so that the semiskilled person may render first aid in the absence of a dental officer. It should be remembered that it is important to prevent the spread of in- fectious bacteria from one individual to another and when, through failure to properly cleanse the hands or to sterilize instruments such transference of bac- teria occurs it is known as cross infection. The spread of disease in this man- ner is the result of carelessness or ignorance and is inexcusable and culpable. Bacteria from the mouth of a patient may be transferred to the operator or to another patient unless the rules of asepsis and sterility are observed. Numerous cases are on record of syphilitic lesions appearing on the fingers of dentists and physicians and infections of this type wTere quite frequent before the advent and use of rubber gloves. Special attention should be paid to the fact that many diseases of the mouth are very contagious and an individual may carry very dangerous bacteria with- out exhibiting any of the symptoms of the disease. If, in some manner, such bacteria are transferred from the person carrying them to another, serious complications may arise through the appearance of the disease in the person to whom the bacteria have been transferred. It is therefore of paramount importance that the fingers and all instruments and materials used in a patient’s mouth should be absolutely clean. It is impracticable and unnecessary to have instruments sterile for dental operations except in those that are of a surgical nature, but they must be clean, that is, they must have been cleaned and steril- ized since they were used in the mouth of a previous patient. Briefly, all in- struments used in an operation must be washed and sterilized following their use. They should be thoroughly washed, then boiled for 15 minutes in an in- strument sterilizer, dried with a clean towel, and handled as little as possible while stowing awray in the instrument cabinet and before being used again in a mouth. Hospital corpsmen must realize how important it is to be clean in the handling of dental instruments and materials and should exercise care in disposing of waste materials. There is but little possibility of cross infection if this routine is followed. EMERGENCY DENTAL TREATMENT 171 Changes in the structure of the teeth may result from the action of putrefac- tive agents in particles of food lodged in the spaces between and around the teeth and also from the presence of various bacteria. In addition to causing decay of the teeth, these agents may cause irritation of the gums. The pre- vention of these changes is considered a part of dental first aid. Decay of the teeth and irritation of the gums to a large degree can be pre- vented by attention to and the execution of a few simple principles. “A clean tooth never decays” is a well-known slogan, which, while not true in its en- tirety, has so much in its favor that it is well worth keeping in mind. Decay occurs most frequently in places which are not kept clean. The sur- faces of the teeth which are seen when the mouth is opened are kept clean and polished, to a great extent, by the cheeks on one side and the food and tongue on the other. The spaces between the teeth, however, are not kept free from debris by the above means or by rough food, which well might serve that purpose. Attention is, therefore, to be directed to these spaces. In the usual procedure of brushing the teeth the surfaces which are kept clean by the tongue, food, and cheeks are the only ones which also are scrubbed with the toothbrush. The spaces which are vital in the prevention of decay of the teeth as a rule are not cleansed. To clean these spaces it is necessary to get in between the teeth and remove from these spaces food debris,. bacteria, and the products of decomposition. Several methods for the attainment of this result have been advocated, among which the use of dental floss has been the most satisfactory. By its use the individual may remove much of the offending material. A much simpler and more efficient method is that in which a small brush with the bristle tufts not set too closely together is laid against the neck of the teeth, bristle ends toward the teeth, and the bristles gently worked into the spaces between the teeth with a sort of oscillating motion. This is to be repeated several times in each vicinity. To help keep tone in the gums the brush should be passed briskly over all surfaces of mucous membrane in the mouth, including the tongue. Using salt on the brush or salt water is a good routine practice, though no objection exists to the use of the most popular denti- frices. Brushing the teeth and gums four times a day, upon arising and after each meal, is given as ideal, hut most persons must be content with a night and morning brushing. EMERGENCY DENTAL TREATMENT The most common dental conditions for which a dental technician or hospital corpsman may be called upon to render first-aid treatment when the services of a dental officer are not immediately available, will now be described. The descriptions of the symptoms and of the first-aid treatment are necessarily brief and are intended to serve only as a reference to assist the hospital corpsman in diagnosing and treating the dental conditions with which he has to deal. Hospital corpsmen should never attempt to administer dental treatment beyond the simplest measures which will relieve pain or render first aid in the event of an accident. Painful cavities. Decay or simple caries is a localized cavity containing decalcified tooth substance. Simple caries is usually painless except when subjected to thermal changes (usually cold), sweets, or pressure from some foreign material such as food within the cavity. The offending cavity may be seen by inspection of the mouth, it may be discovered through exploration with instruments, and often can he located only by transillumination especially when the enamel 154294°—89 12 172 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY apparently is intact and the cavity is within the enamel. Such cavities are often disclosed by the enamel breaking off while eating. Food and soft debris in the cavity should be gently removed with suitable instruments, the cavity washed with warm water, dried with small pellets of cotton, and a small pellet of cotton moistened with dentalone or eugenol placed in the cavity. If temporary stopping is available it may be heated and used to fill the remainder of the cavity. If desired the cavity may be filled with a paste made by mixing zinc oxide and eugenol on a slab to a fairly thick consistency. This paste hardens when it comes into contact with saliva, and if mixed to a putty-like consistency will serve as a temporary filling material for several weeks, and in the meantime will exert a sedative action on the tooth substance. Occasionally a patient points to a perfectly sound tooth and complains that it aches. It is possible, of course, that nerve trouble does exist in that tooth, but it is always advisable to look at the other teeth on the same side of the jaw, both above and below, for a cavity, and if one is found, to cleanse it and apply a sedative, which will often relieve the pain in the tooth pointed out by the patient. Such pain in sound teeth is termed reflected pain. Dental pain resulting from inflamed pulp. The most common type of severe dental pain is toothache from an inflamed pulp which has become infected through a cavity in the tooth. This infection, with the attending inflammation and congestion, compresses the sensitive pulp tissue against the unyielding sides of the pulp cavity. The pain is apt to be sharp and lancinating, tends to increase on lying down, and is accentuated by temperature changes, particularly cold. The tooth is not noticeably tender to percussion (light blows struck with the handle of ail instrument), and does not strike opposing teeth first when bringing the teeth together. Food and soft debris should be gently removed from the cavity with suitable instruments, the cavity washed with warm water, dried with small pellets of cotton, and a small pellet of cotton moistened with dentalone or eugenol, first touched to another piece of cotton to remove excess fluid, inserted into the cavity. The pellet should be small enough to go into the tooth and leave a portion, of the cavity unfilled. Then take another piece of cotton large enough to fill the remainder of the cavity, dip this into compound tincture of benzoin or into sandarac varnish, remove the excess as above, and pack lightly over the sedative dressing. The benzoin or sandarac varnish on cotton will form a gummy, impervious mass when it comes into contact with saliva, thus tending to prevent dissipation of the medicament, will protect the pulp from tempera- ture and pressure changes and will keep out foreign material. This treatment should be renewed every day or two until dental attention is available. Alveolar abscess. If the treatment previously outlined fails to afford relief the pain probably is caused by a pulp which is partially or wholly putrescent, as a result of which gases have formed which are exerting pressure through the root canal into the area around the apex. This forces bacteria and their toxins into the tissues at the end of the root and sets up an inflammation in the structures surrounding the root apex. As this inflammation is outside of the tooth in the alveolus, any medicament applied to the tooth or in the cavity will likely fail to afford relief. The pain will continue until drainage is naturally or artificially established. This type of toothache (alveolar abscess) requires the services of a dental officer to establish drainage through the root canal EMERGENCY DENTAL TREATMENT 173 or through the soft tissues and alveolar wall to the site of the abscess. When swelling becomes apparent pain usually ceases, and the swelling indicates an opening through the tissues has been made by the pus working its way to the surface. Heat may be locally applied on the face. Digital examinations of the tissues of the mouth should be made at inter- vals to determine if a point of fluctuation has developed; when this is found an incision should be made through it directly toward the bone in the direction of the apex of the tooth for the evacuation of pus. Twenty-four to seventy-two hours may elapse between onset of pain and the appearance of swelling. Sedatives may be administered for the relief of pain pending the appearance of the swelling. Gum abscesses. These small abscesses are commonly called gum-boils, are frequently present and appear as small pimples or openings on the gums. This condition, as a rule, is painless, but by no means should it be neglected as in most cases it iftdicates the presence of a dead nerve in a nearby tooth. Gum-boils should receive professional attention at the flrst opportunity in order that the health of the individual may not be menaced. Inflammation of lower third molar regions. The lower third molar teeth (wisdom teeth) often are the cause of pain and swelling during their eruption. Upon looking into the mouth toward the angle of the jaw and just back of the last tooth, occasionally a part of a tooth may be seen coming through the gum with swelling and redness in the vicinity. To relieve this condition, wrap a small instrument or blunt probe firmly with a thin layer of cotton, dip this in half-strength tincture of iodine and gently force between the gum and tooth, working it carefully around the crown of the tooth. This simple treatment will sometimes result in an evacuation of a small amount of pus and relief will be afforded. The patient should be instructed to hold salt water, as hot as can be borne, in the mouth, forcing it back and forth over this area. This should be repeated frequently. Many times this area becomes infected with Vincent’s micro- organisms and treatment in these cases should be watched carefully for any spread of the infection. Using a 10-per cent solution of arsphenamine in glycerin, carry the solution gently around the tooth and under the gum on a probe wrapped with cotton. The mouth should be sprayed with a warm solu- tion of sodium perborate or a half-strength solution of hydrogen peroxide. As a pocket is usually formed distal to these teeth, it is advisable in many cases to drain the pocket, which is done by lightly placing a very small piece of iodoform gauze in the pocket, without pressure. This will maintain drain- age and act as an antiseptic and deodorant until the patient can be seen by a dental officer. Postoperative treatment for haemorrhage following extraction of teeth Haemorrhage may occur from a few hours to several days following the extraction of a tooth. It may originate from a socket or from the surrounding gum tissue. The origin of the bleeding must be determined and treatment applied in that area. The best means of controlling haemorrhage is pressure, and if bleeding occurs from a socket it should be packed with gauze. The socket is first syringed with warm water to dislodge the blood clot and a strip of gauze saturated with epinephrine or thromboplastin is firmly packed into the socket until it is filled. Several gauze napkins, 6 by 6 inches, may 174 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY be folded to produce a pack of appropriate size which, when placed over the socket and between the adjacent teeth, will exert a firm pressure when the jaws are closed. Pressure must be maintained and the compress should not be disturbed for at least 30 minutes. If bleeding persists the treatment should be repeated. The patient should be instructed to avoid all excitement and to remain throughout the day in a sitting or reclining position. The jaws may be held closed by means of a Barton bandage. Sedatives may be given but stimulants should be avoided. Postoperative treatment for pain following the extraction of teeth. It occasionally happens that a day or more after the extraction of teeth severe throbbing pain occurs in the socket from which the tooth has been removed. This condition, known as “dry socket,” indicates that a normal blood cot has failed to form and the socket is empty or is filled with debris. The socket should be gently cleansed by irrigation with warm saline or mild antiseptic solution and a small piece of plain or iodoform gauze moistened with dentalone, eugenol, or coated with dental-analgesic paste very gently inserted in the socket, taking great care not to exert pressure by packing in the gauze. Some relief should be experienced immediately but the pain and discomfort may persist for several days. The irrigation and gauze medi- cation should be renewed daily. If a rise in temperature is observed and the patient seems very ill, osteomyelitis may be suspected and the patient should be taken to a medical officer immediately. Vincent’s infection, oral, or trench month. The symptoms of this disease vary according to the degree of virulence of (he infection and the resistance of the patient. The patient usually complains of pain and discomfort and bleeding of the gums when eating or brushing the teeth. It is characterized by a very red, inflamed appearance of the gums about the teeth, and a film of deadened, white or grayish tissue over the gums and between the teeth which bleeds readily when touched. The condition may be acute with considerable pain and discomfort or it may be less acute with only a thin line of red, inflamed tissue about the teeth, and the grayish-white film noticeable principally between the teeth with very little or none on the gums. In general this disease exhibits a dirty, grayish membrane covering shallow ulcers, with a distinctive, foul breath and excessive bleeding. Vincent’s infection is a highly contagious disease and its spread throughout a group of men may be very rapid if strict precautions are not instituted. Mess gear and all items which might come in contact with the mouth secre- tions must be sterilized immediately after use and before being washed. The sterilization should be done by boiling, or by sterilizing with steam. It is advisable that mess gear be washed and handled by the patient and kept apart from other mess gear throughout the treatment. Measures should be instituted to insure that this is done, and the patient warned that the disease may be transmitted by anything which comes in contact with the mouth, as pipes, tags on tobacco bags, drinking cups, etc. Refer to appendix D, Manual of the Medical Department for further information concerning this condition. The treatment consists in the gentle application of medicaments which will destroy or reduce the causative organisms. No one method of treatment is effective for all cases. One level teaspoonful of sodium perborate dissolved in half a glassful of warm water as a mouth wash, prepared freshly for use every 4 hours, has been found effective in many cases. The solution of sodium perborate, however, in some instances causes additional irritation of oral tissues and this fact should be borne in mind. EMERGENCY DENTAL TREATMENT 175 Equal parts of peroxide of hydrogen and warm water also may be used as a mouth wash, and should be retained in the mouth for at least 2 minutes in order to get the benefit of the oxidizing action. Another treatment is the application several times daily of a 10 per cent solution of arsphenamine in glycerin to all inflamed surfaces, allowing it to remain in contact several minutes and then rinsing the mouth with warm water. When applying arsphenamine solution place cotton rolls or absorbent cotton in the mouth to protect the cheeks and tongue while the medicament is being applied and while it remains in the mouth. The patient should be referred to a dental officer upon the first available opportunity. Symptoms and treatment for fractures of the jaw. Fractures of the jaws exhibit the symptoms of fractures in other bones and in addition there may be an irregularity in the line of occlusion of the teeth. As in other fractures, reduction and immobilization are indicated. If teeth are present they will serve as the best guide for proper reduction and immobiliza- tion, the teeth of one jaw serving as a splint for the other. The bandage type of splint is useless as a permanent method of fixation and dental assistance should be secured as soou as practicable. As a first-aid meas- ure the Barton bandage is not suitable for fractures of the lower jaw though it may be useful in fractures of the upper jaw. The bandage turn in the front of the chin is the objectionable feature of the Barton bandage for fractured mandibles; this turn may be omitted by making a figure-of-eight modified Barton passing under the chin, over the head and down back of the occiput, and repeating six or eight times, which will serve as a temporary support for the mandible. As a rule if the bandage is tight enough to serve as a splint it is too tight for normal circulation. The mouth should be kept clean and liquid diet administered. Operative Dentistry.—Black. Anatomy of the Human Body.—Gray. Refeeences CHAPTER IV Section 1. Materia medica and therapeutics 177 Section 2. Toxicology 257 Page Section 1.—MATERIA MEDICA AND THERAPEUTICS Many of the substances used in the treatment of disease are obtained from the animal, vegetable, and mineral kingdoms. These substances generally are spoken of as medicines, commonly termed drugs, and in studying them it is necessary to consider their source, composition, physical characteristics, chemi- cal properties, preparation and administration,, and physiological and toxicolog- ical action. The science which treats of the substances used as medicines is materia medica. That particular science which relates to the properties of medicinal sub- stances and the application of remedial agents in the treatment of disease is known as therapeutics. In addition to the use of drugs as remedial agents, electricity, water, serums and vaccines, light rays, heat, physical, mechanical, and operative measures, and hygienic agents are employed for curative pur- poses. Therapeutics is divided into three classes known as rational, which is based upon known laws of the remedies and the diseases; empirical, based en- tirely on the results of clinical observation and experience, and general, when remedial agents other than drugs or medicines are used. Medicines may be divided into two general groups—stimulants, which increase the functional activity of the body or of any organ or tissue, and sedatives, which lessen or reduce the functional activity and, according to their composition, are inorganic or organic. The various preparations of drugs or the different forms in which they may be used and the names given to substances of vegetable origin are discussed in the chapter on Pharmacy. Medicinal substances usually are described according to their actions and effects on the body or its organs and tissues, and following is a list of the terms used, with definitions of the therapeutic action of each. Alteratives.—Medicines used to modify processes of nutrition so as to overcome morbid conditions. •Analgesics or anodynes.—Medicines used to allay pain. Anaesthetics.—Medicines used to produce local or general insensibility. Anaphrodisiacs.—Medicines which depress the sexual appetite and function. Anhydrotics.—Medicines which are used to diminish perspiration. Antacids.—Medicines used to neutralize acid in the stomach and intestine. Anthelmintics.—Medicines used to destroy or expel intestinal worms. Antidotes.—Medicines or agents which act upon poisons in such a manner as to alter their composition, rendering them less poisonous, and so preventing their toxic action from being exerted upon the organism.. Antiemetics.—Medicines used to arrest vomiting. Antiperiodics.—Medicines used for the relief of periodically recurring dis- eases, such as malaria. 178 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Antiphlogistics.—Medicines or agents which reduce or dissipate inflam- mation. Antipyretics.—Medicines used in the reduction of body tenqierature in fevers. Antiseptics.—Substances which have the power of preventing the growth and development of bacteria. Antisialics.—Medicines or agents which reduce the secretion of the saliva. Antispasmodics.—Medicines used for the relief of nervous irritability and minor spasms. Antisyphilitics.—Medicines used in the treatment of syphilis. Aperients.—Mild cathartics. Aphrodisiacs.—Medicines which stimulate sexual appetite and function. Aromatics.—Medicines characterized by a fragrant or spicy taste and odor and which stimulate the gastrointestinal mucous membrane. Aromatic hitters.—Medicines which unite the properties of the aromatics and the simple bitters. Astringents.—Medicines which produce shrinkage of mucous membranes or raw tissues, decreasing the amount of exudation from them. Bitters, simple.—Medicines which have a bitter taste and have the effect of stimulating the gastrointestinal mucous membrane without affecting the general system. Cardiac depressants.—Medicines used to lessen the force and frequency of the heart’s action. Cardiac stimulants.—Medicines used to increase the force and frequency of the heart’s action. Carminatives.—Medicines which aid in the expulsion of gas from the stomach and intestine by increasing peristalsis, stimulating circulation, etc. Cathartics.—Medicines which increase or hasten the evacuation of the intes- tine. They are classified according to their power, as follows: Laxatives or aperients, simple purgatives, drastic purgatives, saline purgatives, hydrogogues, cholagogues. Cerebral depressants.—Medicines which lower or suspend the functions of the higher brain after a preliminary stage of excitement. Cerebral excitants.—Medicines which, if given in proper doses, increase the functional activity of the cerebrum without causing any subsequent depression or suspension of the brain function. Correctives.—Medicines which are used to correct or render more pleasant the action of other remedies, especially purgatives. Deliriants.—Medicines which excite the functional activity of the higher brain to such a degree as to disorder the mental faculties and produce intellectual confusion, loss of will power, delirium, and even convulsions. Demulcents.—Substances usually of oleaginous or mucilaginous natures, which soothe and protect the parts to which they are applied. Deodorants.—Substances which destroy or hide foul odors. Diaphoretics.—Medicines which produce increased excretion of sweat. Digestants.—Ferments and acids which have the power of aiding in the solution of food. Disinfectants.—Substances which have the power of destroying disease germs. Diuretics.—Medicines which increase the secretion of the urine. Emetics.—Medicines which produce vomiting. Escharotics or caustics.—Substances which destroy the tissue to which they are applied and produce a slough. Expectorants.—Medicines which increase bronchial secretion. MATERIA MEDTCA AND THERAPEUTICS 179 Febrifuges.—Medicines which lessen fever. Haemostatics.—Medicines which arrest haemorrhages (usually applied to in- ternal bleeding). Hepatic stimulants.—Medicines which increase the functional activity of the liver cells and the amount of bile secreted. Hypnotics.—Medicines which, in the proper doses, produce sleep without nar- cotic or deliriant effects. Irritants.—Substances which, when applied to the skin, produce more or less vascular excitment. When employed to excite a reflex influence on a part remote from the place of application they are termed counterirritants. Rube- facients, the mildest of this group, cause redness (congestion) of the skin. Vesicants or blistering agents produce decided inflammation of the skin and the accumulation of serum between the epidermis and the derma. Motor depressants.—Medicines which lower the functional activity of the spinal cord and the motor apparatus, and in large doses paralyze them directly. Motor excitants.—Medicines which increase the functional activity of the spinal cord and motor apparatus, producing heightened reflex excitability, dis- turbances of motility, and when given in large doses, tetanic convulsions; their ultimate effect being motor paralysis from overstimulation. Mydriatics.—Medicines which cause dilation of the pupil. Myotics.—Medicines which cause contraction of the pupil. Narcotics.—Drugs which “lessen the relationship of the individual to the ex- ternal world.” At first excitant to the higher brain they soon cause profound sleep, characterized by increasing stupor, and if the dose is sufficient, coma, in- sensibility, and death by paralysis of the nerve centers which control organic life. Neurotics.—Medicines which act upon the nervous system. Nutriants.—Medicines which modify the nutritive processes. Nutrients.—Substances which give nourishment to the system. Parasiticides,—Medicines which destroy the various animal and vegetable parasites. Prophylactics.—Medicines which prevent the taking or the development of disease. Pulmonary sedatives.—Medicines which relieve cough and dyspnoea by lessen- ing the irritability of either the respiratory center or the nerves of respiration. Purgatives.—Medicines which produce free evacuation of the bowels. Refrigerants.—Medicines which impart a sensation of coldness and thereby allay thirst and restlessness. Renal depressants.—Medicines or agents which lessen the secretion of the urine. Respiratory depressants.—Medicines which lower the action of the respiratory center. Respiratory stimulants.—Medicines which exalt the function of the respiratory center in the medulla oblongata, quickening and deepening the breathing. Sialogogues.—-Medicines which increase the secretion of the salivary glands (the secretion of the mouth). Soporifics.—Hypnotics. Specifics.—Medicines which have a direct curative influence on certain indi- vidual diseases. Stomachics or gastric tonics.—Medicines which increase the appetite and pro- mote gastric digestion. Styptics.—Medicines or applications to control external haemorrhages. Tseniacides.—Medicines which kill tapeworms. 180 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Tonics.—Medicines which augment gradually and permanently the strength and vital activity of the body or its organs, increasing the vigor of the entire system. Vermicides.—Medicines which kill intestinal worms. Vermifuges.—Medicines which cause the expulsion of intestinal worms. Vesical sedatives.—Medicines which lessen the irritability of the bladder, decreasing the desire to urinate, and relieving vesical pain and tenesmus. Vesical tonics.—Medicines which increase the tone of the muscular fibers in the wall of the bladder, consequently the power for contracting and expelling the urine is increased. Administration of medicines. The normal or adult dose of medicine is based upon the condition that the individual must be 24 years of age and weigh about 150 pounds. Persons under 24 and over 60 years of age require smaller doses in proportion. In computing the dose for persons under 24 years of age, the following rules are applicable. Young's rule directs that the age of the person be taken as the numerator of the fraction and the age plus 12 as the denominator. Thus for a child B years old 3 would be the numerator and 3 plus 12, or 15 the 3 denominator, =1/5 of adult dose. Cowling's rule directs that the age 3+12 at next birthday be taken as the numerator of the fraction, and 24 (the age of the adult) as the denominator of the fraction. In using either of these rules it should be remembered that children usu- ally require larger doses of purgatives, diaphoretics, and diuretics, and smaller doses of narcotics than is called for. When the dose of a drug is spoken of, the amount necessary to produce a medicinal effect in an adult, or the therapeutic dose, ordinarily is meant. The doses given in the Pharmacopoeia and the National Formulary are the average therapeutic doses. In addition, there are the minimum dose, the smallest quantity which can produce a medicinal effect, the maximum dose, the largest quantity which can be given without probable poisoning or harmful effects, the toxic dose, which is the amount producing poisoning, and the lethal dose, which is the smallest dose that will produce death. The average dose is the one usually learned. In the administration of medicines there are many factors which affect the dose, the method of administration, and the frequency of the doses. These conditions, briefly described, are: 1. Age.—Children (see preceding rules) and aged adults as a rule require less than the normal adult dose. 2. Sex.—Females require smaller doses than males. 3. Race.—Negroes usually require larger and Asiatics smaller doses than white people. 4. Physical condition.—Strong, burly patients require larger doses than weak patients. 5. Temperament.—Sanguine (ardent, cheerful, full-blooded) temperaments require smaller doses of stimulants than phlegmatic (heavy, dull, stolid, apathetic) temperaments. 6. Idiosyncrasy.—This is the peculiarity of constitution of individuals to react differently to drugs or other influences. 7. Climate.—People in warm climates, as a rule, require smaller doses of purgatives. 8. Occupation.—Men working out of doors at hard labor will require larger doses than those who sit at a desk all day. 181 MATERIA MEDICA AND THERAPEUTICS 9. Habitual use.—This modifies the dose by lessening the medicinal power of the drug, and the dose must be increased greatly to obtain a medicinal effect (opium, morphine, and cocaine users). 10. Disease.—Disease conditions modify the dose, as in tetanus and peri- tonitis, when larger doses of narcotics are tolerated. 11. Form of the drug.—This controls largely the rate of absorption, as all substances must be reduced to solution before entering the circulation. 12. Time of administration.—Drugs given before a meal are more quickly absorbed than those administered upon a full stomach. 13. Mode of administration.—-As a rule drugs administered hypodermically are used in much smaller quantities. 14. The frequency of administration.—It is obvious that the dose of a drug is less if administered frequently than if administered at long intervals. Medicinal substances may be introduced into the circulation by any one of the following methods: By mouth.—This is the most common of all methods and is usually the most desirable except when very rapid action is required. Subcutaneously.—This method, in which medicines are injected under the skin, frequently is used when rapid action is desired or when the stomach will destroy the virtue of the drug if given by mouth. By rectum.—This method is used when it is impossible to administer drugs by mouth because of vomiting, semi or unconsciousness, delirium, or certain diseases of the gastrointestinal tract. By inunction.—This consists of applying ointments or oily combinations to the skin and rubbing them in. Intravascularly or intravenously.—By this means preparations of drugs are introduced directly into a vein. Inhalation.—By this method medicated vapors or drugs, such as ether or chloroform, are inhaled into the respiratory system. Fumigation.—In this manner easily volatilized drugs are applied directly to the skin, except the head, by means of a vapor bath. By hypodermoclysis.—This consists of introducing solutions of saline into the loose tissues about the breasts, abdomen, or below the scapulae. Intramuscularly.—This consists of injecting readily absorbable, sterile prep- arations of drugs into the muscle tissue. In order to obtain the greatest benefit of their action, as a general rule, hitters are administered before meals; alkalies, if to increase the flow of gastric juice, before meals; if to neutralize the acidity of the gastric juice, after meals; acids, one-half to one hour before meals; laxatives, before retiring; active cathartics, the first thing in the morning; hypnotics, from one-half to two hours before sleep is required; slowly acting drugs (digitalis), at long intervals; rapidly acting drugs (ammonia, nitroglycerin) at very short inter- vals ; such drugs as mercury, arsenic, iron, iodides, not on an empty stomach, but from one-half to one hour after meals. Following is a brief description of drugs in common use, and on the Naval Medical Supply Table, grouped in the various chemical classes to which they belong. INORGANIC MATERIA MEDICA The official Latin and English titles, the common names or synonyms, and the symbolic formulas, if any, appear in black face type in the following descriptions of medicinal substances. Those official in the Pharmacopoeia are indicated by the letters U. S. P. following the names, those recognized by the National Formulary by the letters N. F., and those in New and Nonoffieial Rem- edies by the letters N. N. R. 182 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Iodine and its preparations. lodum, Iodine, I, U. S. P.—Iodine contains not less than 99.5’ per cent of I. Preserve iodine in glass bottles closed with stoppers resistant to corrosion, and in a cool place, protected from light. Properties : Heavy, grayish-black, brittle plates, having a metallic luster and a characteristic odor. One gram is soluble in 2,950 cc of water, in 12.5 cc of alcohol, in 80 cc of glycerin, and in 4 cc of carbon disulfide. It is freely soluble in chloroform, in carbon tetrachloride, and in ether, and is dissolved by aqueous solutions of iodides. Iodine unites actively with iron and other metals. In weighing iodine use a hone or rubber spatula, and paraffined paper on the scale pans. With starch paste iodine gives a deep blue color. Iodine stains may be removed from linen by the application of a solution of sodium thiosulfate. Source: Iodine is now obtained principally from the mother liquors obtained in the purification of crude Chili saltpeter (sodium nitrate). Some iodine is obtained from the ashes obtained by burning seaweeds. A new source of iodine is the brine issuing from the oil in petroleum oil-wells. In Chili salt- peter iodine occurs as sodium iodate mixed with sodium nitrate. Action and Uses; See preparations of iodine. The antidote is starch paste. Average dose: 0.01 Gm, or % grain. Tinctura lodi, Tincture of Iodine', U. S. P.—An alcoholic solution of iodine and potassium iodide. One hundred cc contains not less than 6.5 Gm. nor more than 7.5 Gm. of I, and not less than 4.5 Gm. nor more than 5.5 Gm. of KI. Preserve it in glass bottles, closed with stoppers resistant to corrosion, and in a cool place, protected from light. Preparation : See U. S. P. Action and Uses: It is applied externally as a counter-irritant, disinfectant, and parasiticide. It may be applied to any part of the body externally except the eye. An alcoholic solution (half strength) containing equal parts of the tincture and alcohol is employed in the disinfection of the skin before opera- tions. It penetrates into the pores and acts as a powerful germicide. It should never be painted over a surface that previously has been washed with bi- chloride of mercury solution, because in the presence of the bichloride new compounds are formed which are intensely irritating, especially under a dress- ing, and blistering of the skin is liable to occur. To get the best germicidal results from tincture of iodine, it should not be applied to a surface wet with water. Internally tincture of iodine is used as an alterative. It acts as an irritating poison in large doses. The antidote is starch paste or starchy foods, such as bread and mashed potatoes. Iodine stains can be removed from linen with a solution of sodium thiosulfate. Average dose: 0.1 cc or iy2 minims (diluted with water). Tinctura lodi Mitis, Mild Tincture of Iodine, U. S. P.—Mild Tincture of Iodine contains, in each 100 cc, not less than 1.8 Gm. and not more than 2.2 Gm. of I and not less than 2.1 Gm. nor more than 2.5 Gm. of Nal dissolved in 50 per cent alcohol. Preserve it in the same manner as Tincture of Iodine. Action and Uses; This weak tincture is actively antiseptic and when applied to the abraded surface is not so painful as the strong tincture. The presence of iodides in both the strong and the weak tinctures improves their stability and increases their penetrability. With acetone iodine forms an irritating compound. A solution containing 1 cc of Mild Tincture of Iodine to 100 cc of 70 per cent alcohol is used as a local application in the treatment of trichophytosis (athlete’s foot). MATERIA MEDIOA AND THERAPEUTICS 183 liquor lodi Compositus, Compound Solution of Iodine (LugoTs Solution), U. S. P.—Compound Solution of Iodine is a solution containing, in each 100 cc, not less than 4.5 Gm. and not more than 5.5 Gm. of I, and not less than 9.5 Gm. and not more than 10.5 Gm. of KI. Preserve it in glass bottles, closed with stoppers resistant to corrosion, and in a cool place, protected from light. Action and Uses: It is given internally for the preoperative treatment of toxic goiter. It should be highly diluted with water, when given by mouth, to prevent gastric irritation. Average dose: 0.2 cc or 3 minims. Oxygen and its compounds with hydrogen. Oxygenum, Oxygen, 0, U. S. P.—It contains not less than 99 per cent of O by volume. For convenience it is usually supplied in compressed form in metallic cylinders. Properties: A colorless, odorless, tasteless gas, which supports combustion more energetically than air. It is slightly soluble in water. Preparation : Oxygen is separated from the air by extreme cold and high pressure. When liquid air is allowed to vaporize the nitrogen escapes first be- cause of its greater volatility, and the gas that comes off last is nearly pure oxygen. Action and Uses : It is employed to relieve difficult respiration as in pneumo- nia. It is administered by inhalation in the treatment of poisoning by carbon monoxide. It is used with nitrous oxide in anaesthesia to prevent cyanosis. When the oxygen tent is being used great care must be exercised to prevent persons entering the room with a lighted cigarette. Aqua, Water, H20, U. S. P.—A clear, colorless, practically tasteless and odorless liquid. It has a pH of not less than 5.8 and not more than 8.3. Ordinary water contains in solution or suspension traces of salts, organic matter, and gases, vary- ing in amounts with different localities. These impurities in limited amounts do not render water unfit for drinking purposes or for making pharmaceutical preparations containing some drugs, but their presence is objectionable in cer- tain cases. Aqua Destillata, Distilled Water, H20, U. S. P.—Water purified by distillation. It is a clear, colorless liquid, without odor and taste. It has a pH between 5.8 and 7. Aqua Destillata Sterilisata, Sterilized Distilled Water, U. S. P.—It is freshly distilled water recently sterilized. See U. S. P. page 66. It should be used with- in 24 hours after sterilization when stored in stoppered containers. Aqua Redestillata, Redistilled Water, Triple Distilled Water, U. S. P.—Redis- tilled water is free from nonvolatile matter and gases; also from microorganisms or other oxidizable matter. Redistilled water intended for intravenous use should be sterilized within 2 hours after its redistillation and should be pre- served in a suitable manner against contamination. It should be used for intravenous use only on the same day it is sterilized. Hard, insoluble glass flasks previously rinsed with triple distilled water should be used for sterilizing triple distilled water. See Pyrogen, page 1650 of Remington’s Practice of Pharmacy, eighth edition. Nitrogen, compounds. Nitrogenii Monoxidum, Nitrogen Monoxide (Nitrous Oxide), N20, U. S. P.— It contains not less than 95 per cent by volume of N20. It is supplied in com- pressed form in metallic cylinders. It is a colorless gas, having a slight, char- acteristic odor and in aqueous solution a somewhat sweetish taste. It supports the combustion of many substances. One volume of the gas dissolves in 1.5 184 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAYiT volumes of water under normal pressure and at 20° C. It is more freely soluble in alcohol than in water. Action and Uses: It is a quick-acting anaesthetic, requiring only a few in- halations to produce unconsciousness. It is usually given mixed with oxygen. Sulfur. Sulfur Suhlimatum, Sublimed Sulfur (Flowers of Sulfur), S, U. S. P.—It con tains 99.5 per cent S. Properties : A fine, yellow, crystalline powder having a faint odor and taste. It is insoluble in water and nearly insoluble in alcohol. It is soluble in carbon disulfide, ether, and in olive oil. It burns in air to form sulfur dioxide gas. Action and Uses : Sublimed sulfur is not given internally. It is used in the preparation of Washed Sulfur. Sulfur Lotum, Washed Sulfur, U. S. P.—It contains not less than 99.5 per cent of S. Washed sulfur is sublimed sulfur which has been treated with ammonia water. Ammonia water removes traces of arsenic and sulfuric acid which may be present in sublimed sulfur. After the removal of these impuri- ties sulfur is fit for internal use. Action and Uses: Used internally as a laxative in Compound Powder of Senna, U. S. P. Average dose: 4 Gm., or 1 dram. Sulfur Prsecipitatum, Precipitated Sulfur, U. S. P.—It contains not less than 99.5 per cent of S. Properties : A very fine, pale yellow, amorphous or microcrystalline powder without odor or taste. Action and Uses: The particles are lighter and more easily suspended than washed or sublimed sulfur. Ointments made with precipitated sulfur are smoother than those made with sublimed sulfur. It is used in making Sulfur Ointment, U. S. P. It is suitable for internal administration. Average dose: 4 Gm., or 1 dram. ITnguentum Sulfuris, Sulfur Ointment, U. S. P.—It contains not less than 13.5 per cent and not more than 16.5 per cent of S. Composition : Precipitated sulfur, 15 Gm., wool fat, 5 Gm., yellow wax, 5 Gm., white petrolatum, 75 Gm. Action and Uses: It is used externally as a parasiticide against scabies; and in seborrheal diseases. When applied to the face it should be diluted with 5 parts of Unguentum, U. S. P. Carbon. Carbo Activatus, Activated Charcoal, U. S. P.—The residue from the de- structive distillation of various organic materials, treated to increase its adsorptive power. When Carbo Ligni is prescribed, Carbo Activatus may be dispensed. Preserve Activated Charcoal in well closed containers. Description : A fine, black, odorless, and tasteless powder, free from gritty matter. It is estimated that 1 cc of finely divided charcoal possesses a total surface of approximately 1,000 square meters. Action and Uses : It is given internally as an adsorbent of gases in intestinal fermentation. It is used in pharmaceutical manufacturing as a decolorizing agent. It is one of the substances found in most all gas masks used in chemi- cal warfare. (Chemical Warfare, Fries and West, p. 242.) Average dose: 2 Gm., or 30 grains. Carbonei Dioxidum, Carbon Dioxide, C02, U. S. P.—It contains not less than 99 per cent by volume of COs. It is supplied in compressed form in metallic cylinders. MATERIA MEDICA AND THERAPEUTICS 185 Description : A heavy, odorless, colorless gas. The taste of an aqueous solu- tion of the gas is faintly acid. One volume of carbon dioxide dissolves in about one volume of water. Carbon dioxide extinguishes a flame. Action and Uses : It is a stimulant to respiration. It is added to oxygen in varying proportions, from 1 to 5 per cent carbon dioxide and from 95 to 99 per cent oxygen, for supplying artificial respiration and as a stimulant to the re- spiratory center. The proportion of carbon dioxide to oxygen must be carefully regulated because an excess of carbon dioxide causes death by asphyxia. Boron. Acidum Boricum, Boric Acid (Boracic Acid), HsBOs, U. S. P.—Boric acid con- tains not less than 99.5 per cent of HsBOs. Preserve it in well closed containers. Properties : Colorless scales of a pearly luster, or crystals, or a white powder, slightly unctuous to the touch. It is odorless and is stable in the air. One gram is soluble in 18 cc of water, and in 18 cc of alcohol, and in 4 cc of glycerin. An aqueous solution is slightly acid to litmus paper. Action and Uses : Boric acid is a mild antiseptic. Externally it is used as a dusting powder either alone or with diluents such as starch or talcum. An aqueous solution containing from 2 to 4 per cent is used as an eye lotion. Boric acid solution has caused death in infants when given internally by mistake. Unguentum Acidi Borici, Boric Acid Ointment, U. S. P.—It contains not less than 9 per cent and not more than 11 per cent of H3BO3. Each 100 grams of oint- ment contains 10 Gm. boric acid, 5 Gm. wool fat, 5 Gm. white wax, and 80 Gm. white petrolatum. Average dose: 0.5 Gm., or 8 grains. Action and Uses : It is used as an emollient and protective on superficial wounds and abrasions. Its antiseptic properties are very slight. Inorganic or mineral acids. These compounds all contain hydrogen which is replaceable by metals forming salts, having a characteristic sour taste and corrosive action, and change the color of blue litmus to red. When acted upon by a base (alkali) they are neutralized and in turn neutralize the base, forming a salt and water. This is why an acid is used as an antidote for poisoning by a base, and a base as the antidote for acid poisoning. An acid is defined as a compound of hydrogen with an electronegative element or radical. Sulfur (S) is an electronegative element and when it is combined with hydrogen produces ELS, hydrosulfuric acid; SO* is the electronegative sulfate radical, and when it is combined with hydrogen produces ELSCb, sulfuric acid. The strong inorganic acids should be handled with great care because they are very corrosive and poisonous. When given internally they should be highly diluted, and should be taken through a glass tube to prevent injury to the teeth, followed by rinsing the mouth with a solution of sodium bicarbonate. The chemical antidote for acid poisoning is any mild alkali; as lime water, milk of magnesia, chalk, bicarbonate of soda, etc. Acidum Hydrochlorieum, Hydrochloric Acid, HC1, U. S. P.—An aqueous solu- tion containing not less than 35 per cent nor more than 37 per cent of HCi. Preserve it in glass-stoppered bottles. It should be noted that about 64 per cent of the liquid is water and only 36 per cent (by weight) is hydrochloric acid (gas). Absolute HOI is a gas and this preparation is a solution of HCI gas in water. Preparation: It is made by acting on sodium chloride (common salt) with sulfuric acid. (1) 2NaCl+H2S04=HCl+NaCl+NaHS04; (2) NaCl+NaHS04= HCl-t-Na2S04. 186 HANDBOOK OF TEE HOSPITAL CORPS, II. S. NAVY Properties : It is a colorless, fuming liquid having a pungent odor and an intensely acid taste. The fumes and odor disappear on adding the acid to twice its volume of water. It is strongly acid to litmus. Salts of hydrochloric acid are known as chlorides (sodium chloride). An aqueous solution containing not less than 9.5 Gm. nor more than 10.5 Gm. of HC1 in each 100 cc is known as diluted hydr®chloric acid. Action and Uses: Hydrochloric acid is a normal constituent of the gastric juice and sometimes is administered to make up any deficiency of this substance in the gastric juice. Its principal use is in the manufacture of chlorides (salts), many of which are used in medicines. It is used with nitric acid in making nitrohydrochloric acid. Average dose: 1 cc or 15 minims of the 10-per cent diluted acid. It should be diluted further with 1 fluidounce of water and taken through a glass tube, to avoid injury to the teeth. Acidum Sulfuricum, Sulfuric Acid, H2SO4, U. S, P.—A liquid containing not less than 94 per cent nor more than 98 per cent of H2SO4. Preserve it in glass-stoppered bottles. Properties : A colorless, odorless liquid, of oily consistence, very caustic and corrosive; strongly acid to litmus even when highly diluted. Specific gravity about 1.84 at 25° C. Miscible with water or alcohol with the evolution of much heat; the acid must he added ivith great caution to the diluent. In mix- ing water and sulfuric acid the acid always should he added sloioly with stirring to the water, and not the water to the acid. When mixed in a glass vessel the acid should be added slowly to avoid a sudden increase of tempera- ture with possibility of breaking the glass vessel. Because of its great affinity for water it is used as a desiccating (drying) agent. Being one of the strongest acids known, it is capable of decomposing salts of other acids, forming salts of sulfuric acid, and setting free the other acids. This principle is demonstrated in the making of hydrochloric and nitric acids. Preparation: There are several methods now employed in the manufacture of sulfuric acid, the principles involved being practically the same. Sulfur is burned with the oxygen of the air forming sulfur dioxide; the sulfur dioxide is oxidized by the action of either an oxidizing agent (nitric acid) or a catalytic agent (platinum sponge) to sulfur trioxide. The sulfur trioxide then is brought in contact with steam in a leaden chamber (sulfuric acid does not act on lead), forming sulfuric acid. The simplest expression of the reactions involved is as follows: (1) s+o2 =so2. (2) 3S02+2HN03 =3S0.+Ha0+N,01 (3) SO3+H2O =H2S04. Diluted sulfuric acid is an aqueous solution containing not less than 9.5 Gm. nor more than 10.5 Gm. of H2S04 in each 100 cc. Action and Uses : Sulfuric acid rarely is given internally. Its principal use is in manufacturing other preparations. Not only is it used in the prepara- tion of salts (sulfates) of sulfuric acid, but also in the manufacture of other acids from their salts. Average dose of the diluted acid is 1 cc or 15 minims, Acidum Nitricum, Nitric Acid (Aqua Fortis), HN03, U. S. P.—An aqueous solution containing not less than 67 per cent nor more than 70 per cent of HNOs. Preserve it in glass-stoppered bottles protected from light, and in a cool place. Properties: Nitric acid is a fuming liquid, very caustic and corrosive, and has a peculiar, somewhat suffocating odor. It should be handled with extreme care. MATERIA MEDICA AND THERAPEUTICS 187 Preparation: Made by the action of sulfuric acid on sodium nitrate. NaN03+H2S0i=NaHS04+HN03. Action and Uses : Nitric acid rarely is given internally. It is used in the manufacture of salts of nitric acid (nitrates) and in the manufacture of ex- plosives (trinitro-phenol, glyceryl trinitrate, trinitro-toluol, etc.). It is an extensively used oxidizing agent, breaking down in the presence of oxidizable substances, as follows: 2HN03=H20+N202-|-3C). Applied to tissues it acts as an energetic caustic and is used for cauterization and to remove warts. It is used with hydrochloric acid in the preparation of nitrohydrochloric acid. When applied to the skin it produces a yellow stain due to the formation of xanthoproteic acid. The alkali elements and their compounds The alkali metals are potassium, sodium, lithium, and the radical am- monium. Chemically they are strongly electropositive, being directly opposite to the halogens. They are monovalent, soft, waxlike in consistence, having a low melting point, readily oxidize in the air and decompose water forming strong hydroxides (alkalies). These strong alkalies are very caustic and poisonous. Nearly all the salts of these alkalies (formed by their union with acids) are soluble in water. Potassium, sodium, and lithium as such have no special medicinal action of value. The medicinal properties of their chemical compounds are exerted by the acid radicals with which they are combined; therefore the medicinal properties of the alkali salts vary greatly. The chemical antidote for th& strong alkalies is any weak acid, as citric acid, vinegar, diluted acetic acid, etc. Neutralization of the acid should be followed by giving large doses of cottonseed oil. When acids and alkalies are brought together in solution they neutralize each other forming new compounds (salts). In this way they act as antidotes for each other. Potassii Hydroxidum, Potassium Hydroxide (Caustic Potash), KOH, U. S. P.— It contains not less than 85 per cent of KOH. Preserve it in well-closed con- tainers. If bottles are used they must be made of hard glass, and cork stoppers should be paraffined. Properties : Potassium hydroxide occurs in dry, white, or nearly white flakes, fused masses, or sticks; is hard, brittle and odorless. Great caution is necessary in handling it, as it rapidly destroys organic tissue. When exposed to the air it rapidly absorbs carbon dioxide and moisture and deliquesces. It is very soluble in water, alcohol and glycerin. (All the salts of potassium are soluble in water except potassium bitartrate). It is strongly alkaline to red litmus, turning it blue even in a very dilute solution. Preparation : It is made by electrolysis (passing an electric current through potassium chloride). Action and Uses: Pure potassium hydroxide is not given internally. If a large quantity should he swallowed accidentally, give vinegar or lemon juice as the antidote. Potassium hydroxide is used in making soap (soft soap). Lye may be composed of potassium hydroxide, although it usually contains sodium hydroxide, a cheaper substance. It sometimes is used as a caustic, but its principal use in medicine is in the manufacture of potassium salts. Potassii Acetas, Potassium Acetate, CHsCOOK, U. S. P.—It contains when dried to constant weight at 150° C. not less than 99 per cent of CH3COOK. Preserve it in airtight containers. Properties : It is very deliquescent on exposure to the air, and is very soluble in both water and alcohol. An aqueous solution is alkaline to litmus. 154294°—39 13 188 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Preparation : It is made by tbe action of acetic acid on potassium bicarbonate. KHCOa+CHsCOOE^CHaCOOK+COz+EUO. Action and Uses: Used as a diuretic, diaphoretic, and to render tbe urine alkaline. In large doses it acts as a laxative. It is decomposed in tbe system, forming carbonates. Average dose: 1 Gm. or 15 grains. Potassii Bicarbonas, Potassium Bicarbonate, KHCOs, U. S. P.—It contains, when dried to constant weight in a desiccator over sulfuric acid, not less than 99 per cent of KHOOs. Preserve it in well closed containers. Properties : It is very soluble in water, but almost insoluble in alcohol. When a solution of potassium bicarbonate is heated it is converted into potas- sium carbonate. An aqueous solution is slightly alkaline to litmus. Preparation: It is made by passing carbon dioxide through a solution of potassium carbonate until it is fully saturated. K2C03-)-C02+H20—2KHC03. Action and Uses: Its action when given internally is very much like that of potassium acetate. It renders the blood and urine alkaline. In manufac- turing pharmacy it is used in the preparation of many of the other potas- sium salts. Average dose: 1 Gm. or 15 grains. Potassii Bitartras, Potassium Bitartrate (Cream of Tartar), EOOC.CHOH. CHOH.COOH, U. S. P.—It contains, when dried to constant weight at 100° C., no less than 99.5 per cent of KOOC.CHOH.CHOH.COOH. Preserve it in well- closed containers. Properties: Occurs as a colorless or slightly opaque, gritty powder, odor- less, and having a pleasant acidulous taste. It is very slightly soluble in water (the only sparingly soluble potassium salt in common use), and insolu- ble in alcohol. A saturated solution is acid to litmus. Preparation : It is made by purifying tartar, a substance deposited in wine casks during fermentation of grape juice in making grape wines. Action and Uses: Occasionally given as a hydragogue cathartic. It is one of the constituents of baking powders. In baking powder it acts slowly on bicarbonate of sodium, liberating carbon dioxide, which becomes entangled in the dough and causes it to rise. It sometimes is used as a diuretic and laxative. Tartrates are not oxidized in the system like citrates and acetates and do not act as alkalizers. Average dose: 2 Gm. or BO grains. Potassii Chloras, Potassium Chlorate, KClOs, U. S. P.—It contains not less than 99 per cent of KClOs. Preserve it in well-closed containers. Great caution should be observed in handling it, as dangerous explosions are liable to occur when it is heated or subjected to concussion or trituration with organic substances (cork, tannin, dust, sugar, etc.) or with sulfur, sulfides, hyposulfites, or other easily oxidizable substances. Properties: It occurs as colorless crystals or a white granular powder, odorless, and having a peculiar cooling taste. It is soluble in 16.5 parts of water, soluble in glycerin, and insoluble in alcohol. It is capable of yielding oxygen when heated. Preparation : It is made by boiling together a solution of potassium chlor- ide and calcium hypochlorite. Action and Uses: Applied locally in aqueous solution it acts as an anti- septic and stimulant to mucous membranes. It is decomposed easily by septic matter, yielding nascent oxygen, to which it owes its antiseptic properties. It is used in the following inflammatory conditions of mucous membranes: Catarrhal inflammations of the mouth and fauces, ulcerative and mercurial MATERIA MEDICA AND THERAPEUTICS 189 stomatitis, nursing sore mouth, and tonsillitis. When given internally in large doses it is likely to cause destruction of the red blood cells. Average dose: 0.25 Gm. or 4 grains (rarely used internally). Potassii et Sodii Tartras, Potassium and Sodium Tartrate (Rochelle Salt), U. S. P.—It contains, when rendered anhydrous by drying at 150° C., not less than 99 per cent of KOOC.CHOH.CHOH.COONa. It contains not less than 21 per cent and not more than 26 per cent of water. Preserve it in well-closed containers. Properties: Occurs as colorless, transparent crystals or a white granular powder, odorless, and having a saline taste. Very soluble in water and almost insoluble in alcohol and slightly efflorescent in dry air. Its aqueous solution is slightly alkaline to litmus. Preparation : Made by adding potassium bitartrate to a solution of sodium carbonate. 2KHC4H406+NasCOs^KNaCJUOo+C02+H20. Action and Uses : Rochelle salt is an extensively used purgative in the form of Seidlitz powder, U. S. P. A Seidlitz powder consists of two powders, one wrapped in white paper, and the other wrapped in blue paper. The contents of the blue paper are: Rochelle salt, 115 grains, and sodium bicarbonate, 38 grains. The white paper contains 33 grains of tartaric acid. When adminis- tered the contents of the two powders are dissolved separately, each in half a glass of water, and then poured together and taken while effervescing. The effervescence is caused by the action of the tartaric acid on the bicarbonate of sodium. In this reaction sodium bitartrate is formed. Average dose: 10 Gm. to 2% drams. Potassii lodidum, Potassium Iodide, KI, U. S. P.—-It contains, when dried to constant weight at 100° C., not less than 99 per cent of KI. Preserve it in well closed containers. Properties : It is very soluble in water and glycerin; slightly soluble in alcohol. Slightly deliquescent in moist air. Its aqueous solution is slightly alkaline to litmus. Preparation : It is made by the action of iodine on an aqueous solution of potassium hydroxide. (1.) 6K0H+3I2=5KI+KI03+BH20. (2.) KIOs+SC— KI+3CO. Action and Uses: A valuable and much used alterative. It is used in the treatment of syphilis, rheumatism, and arteriosclerosis. It also is used for chronic lead', mercury, and arsenic poisoning, forming with these metals double soluble salts which are eliminated easily. Average dose: 0.3 Gm. or 5 grains. Give small doses for chronic lead poisoning and large doses for syphilis. Potassii Permanganas, Potassium Permanganate, KMn04, U. S. P.—It contains, when dried to constant weight in a desiccator over sulfuric acid, not less than 99 per cent of KMn04. Preserve it in glass-stoppered bottles. Potassium per- manganate when in solution or in the dry condition must not be brought into contact with organic or other readily oxidizable substances, as dangerous ex- plosions are liable to occur. Properties: It occurs as slender prisms, of a dark purple color, odorless and having a disagreeable astringent taste. It is stable in the air. It is soluble in 14.2 parts of water. An alcoholic solution cannot be made because it is decomposed by alcohol. It is a powerful oxidizing agent, two molecules in acid solution yielding five atoms of oxygen. When it comes in contact with organic matter it is decomposed with the liberation of oxygen. This property makes it a valuable antiseptic and disinfectant. 190 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Preparation: It may be made by fusing together a mixture of potassium hydroxide, manganese dioxide, and potassium chlorate, forming potassium manganate. When the potassium manganate is boiled with water potassium permanganate is formed. (1) 3Mn02+6K0H+KC103=3K2Mn04+KCI+3H20. (2) 3K2Mn04+3H20=2KMn04+Mn02+4K0H+H20. Action and Uses : It is used as an antiseptic astringent irrigating fluid, es- pecially for the urethra and bladder, in strengths of from 1—4,000 to 1-10,000. It seldom is used externally, largely on account of the objectionable stain which it leaves. A 5 per cent solution is used in the treatment of poisoning by ven- omous snakes by injection into the wound. It also is used in the treatment of morphine poisoning. It has been used with formaldehyde solution to volatilize formaldehyde gas in disinfection of rooms, but is has been displaced for this pur- pose by barium dioxide, a cheaper substance. Average dose: 0.06 Gm. or 1 grain. Sodii Hydroxidum, Sodium Hydroxide (Caustic Soda, Sodium Hydrate), NaOH, U. S. P.—It contains not less than 95 per cent of NaOH. Preserve it in well- closed containers. If bottles are used as containers they must be made of hard glass, and cork stoppers should be paraffined. Properties ; It occurs in dry, white or nearly white fused masses or sticks, hard and brittle, showing a crystalline fracture. Exposed to the air, it rapidly deliquesces, absorbs carbon dioxide, and becomes covered with a coating of sodium carbonate. Great caution is necessary in using it, as it rapidly destroys organic tissue. It is very soluble in water and alcohol. It closely resembles potassium hydroxide in its properties, being a very strong alkali. Preparation : It is made by electrolysis of sodium chloride; also by the action of slaked lime on a solution of sodium carbonate. (Na2C03+Ca(0H)2=2Na0H +CaC03.) Action and Uses: It is used in the preparation of compound cresol solution, solution of sodium hydroxide, and magma magnesia. It seldom is used in- ternally, because it is too caustic. As a caustic it may be used like potassium hydroxide. The antidote is vinegar, diluted acetic acid, citric acid, lemon juice, etc. Sodium hydroxide is used extensively in a crude, impure form, for house- hold cleaning under the name of lye. Sodii Bicarbonas, Sodium Bicarbonate (Bicarbonate of Soda, Baking Soda), NaHCOs, U. S. P.—It contains, when dried to constant weight in a desiccator over sulfuric acid, not less than 99 per cent of NaHCOs. Preserve it in well-closed containers in a cool place. Properties: It is a white, crystalline powder, odorless and having a cooling, mildly alkaline taste. It is stable in dry air, but slowly decomposes in moist air. When its aqueous solution is heated, even mildly, it loses carbon dioxide and is converted into sodium carbonate as follows: 2NaHC03=Na2C03+H20 +C02. It is fairly soluble in water, and insoluble in alcohol. Its aqueous solu- tion is alkaline to litmus, and the alkalinity increases as the solution stands, is agitated or heated. When treated with acids it effervesces (the same thing oc- curs when any carbonate is treated with an acid). Preparation: It is made by the Solvay process (ammonia soda process). A concentrated solution of sodium chloride is mixed with ammonia water; carbon dioxide under pressure is forced into this mixture, resulting in the formation of sodium bicarbonate and ammonium chloride. Sodium bicarbonate is precipi- tated (being less soluble) and the ammonium chloride remains in solution. The reaction may be expressed: This MATERIA MEDICA AND THERAPEUTICS 191 process also may be used in making sodium carbonate. After making the bicar- bonate this may be heated, driving off carbon dioxide and water, leaving behind sodium carbonate. Action and Uses : A valuable and popular antacid. It is given frequently for hyperacidity of the stomach (heartburn), but it must be remembered that while it neutralizes the acid contained in the stomach it also causes increased secretion of more acid, and may defeat the purpose for which it is given if ad ministered over a long period. When used for heartburn it usually is com- bined with ammonium carbonate and oil of peppermint and given in tablet form (soda-mint tablets). It is used externally in saturated aqueous solution for the treatment of burns and poisoning by poison ivy. It may be used in the prepara- tion of other compounds of sodium. It is the principal ingredient in baking powder. In making bread this substance, when acted upon by either alum or cream of tartar, liberates carbon dioxide, which becomes entangled in the dough and causes it to rise. The term “soda” very often is applied to this compound, but “soda” is an indefinite term and might mean sodium carbonate or even caustic soda. For the preparation of sterile solution of sodium bicarbonate for in- travenous use see U. S. P. page 468. A solution for intravenous use should be colorless with phenolphthalein. Average dose: 1 Gm. or 15 grains. Sodii Biphosphas, Sodium Biphosphate (Sodium Dihydrogen Phosphate, Sodium Acid Phosphate), NaH2P04, U. S. P.—Sodium biphosphate, when dried to constant weight at 100° C., contains not less than 98 per cent of NaH2P04. It contains not less than 10 per cent and not more than 15 per cent of water. Preserve it in air-tight containers. Description : Colorless crystals or a white, crystalline powder. It is odorless and is slightly deliquescent. It is freely soluble in water but is practically in- soluble in alcohol. An aqueous solution of the salt is acid to litmus paper and effervesces with sodium carbonate. Action and Uses : It is given to increase the acidity of the urine. It is given in conjunction with methenamine, not at the same time but between the methe- namine doses, in order to render the urine acid when the methenamine is ex- creted by the kidneys. The acid urine decomposes the methenamine setting free formaldehyde which acts as an antiseptic in the urinary tract. If sodium biphosphate and methenamine are given at the same time decomposition be- tween the two will take place in the stomach which is not desired. If sodium biphosphate is not available use sodium phosphate and to each gram of sodium phosphate in solution add 1 cc of diluted hydrochloric acid or 4 cc of diluted phosphoric acid. Average dose; 0.6 Gm. or 10 grains. Sodii Boras, Sodium Borate (Borax, Sodium Tetraborate, Sodium Pyroborate), U. S. P.—It contains not less than 52.32 per cent nor more than 54.92 per cent of anhydrous sodium borate (sodium biborate or tetraborate), corresponding to not less than 99 per cent of the crystallized salt (Na2B407+10H2O). Pre- serve it in well-closed containers. Properties : It occurs as colorless, transparent prisms, or as a white powder, odorless, and having a sweetish alkaline taste. It is slightly efflorescent in warm, dry air. It is fairly soluble in water, very soluble in glycerin, and in- soluble in alcohol. Its aqueous solution is alkaline to litmus. It has the prop- erties of an alkali but is milder than sodium carbonate. When mixed with glycerin it decomposes alkali bicarbonates with effervescence (this accounts for the effervescence in the preparation of Dobell’s solution). An aqueous solution shows an alkaline reaction toward litmus, but when dissolved in glycerin it 192 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY gives an acid reaction, and when the glycerin solution is largely diluted with water the reaction is changed back to alkaline. Preparation: Sodium borate is found native (as sodium borate) as a crys- talline deposit in the blue mud at the bottom of Clear Lake and near Death Valley in California, and in lakes in other parts of the world. It can be made by treating crude boric acid with sodium carbonate. Action and Uses ; Sodium borate possesses mild antiseptic and cleansing properties, and because of them it is used very often in alkaline mouth washes and gargles. It is one of the ingredients in compound solution of sodium borate, N. F. (Dobell’s solution). It rarely is used internally. As a household clean- ing agent (borax) it is used extensively where a mild alkali is desired in the cleaning of delicate fabrics. It also is used as a food preservative. A 1 per cent solution in distilled water is used as an eye lotion in conjunctivitis. Sodii Bromidum, Sodium Bromide. NaBr, U. S. P.—It contains, when dried to constant weight at 100° 0., not less than 99 per cent of pure NaBr. Preserve it in well-closed containers. Properties : It occurs as colorless, or white, cubical crystals, or as a white powder, odorless, and having a saline taste. It is very soluble in water and fairly soluble in alcohol. Its aqueous solution is neutral or faintly alkaline to litmus. It absorbs moisture from the air without deliquescing. Preparation: It can be made by methods like those employed in making potassium bromide, using NaOH instead of KOH. Action and Uses : It is used as a cerebral depressant and nerve sedative. Its action is much like that of potassium bromide, but less irritating to the stom- ach and less depressing. It is useful for quieting nervous excitability in neu- rasthenia and hysteria. It is given as an adjunct to hypnotics such as chloral. When given for a long time it disturbs the digestion and produces irritation of the skin. Average dose: 1 Gm. or 15 grains. Sodii Carbonas Monohydratus, Monohydrated Sodium Carbonate, NaaCOs+ILO, U. S. P.—It contains, when rendered anhydrous by gentle ignition, not less than 99.5 per cent Na2C03, and not less than 10 per cent and not more than 15 per cent of water. Preserve it in well-closed containers. Properties : It is a white, crystalline, granular powder, odorless and having a strong alkaline taste and reaction. When exposed to the air, under ordinary conditions, it absorbs only a slight percentage of moisture; exposed to warm, dry air at or above 50° 0., the salt effloresces, and at 100° C. it becomes anhydrous. It is very soluble in water and glycerin, and is insoluble in alcohol. An aqueous solution is strongly alkaline to litmus paper. Preparation ; There are three methods by which sodium carbonate may be made: LeBlanc’s process, the Cryolite process, and the Solvay process. The Solvay process has been explained under sodium bicarbonate. (The chemical reactions involved in the LeBlanc and the Cryolite processes are too compli- cated to treat in this book. The student is referred to standard textbooks on pharmacy for further information.) Action and Uses ; Because of its strong alkaline reaction and irritating effect on the stomach, sodium carbonate seldom is given internally; sodium bicar- bonate is preferred when the internal antacid effect of soda is desired. Added to water in which instruments are being boiled (1 teaspoonful to a gallon of water), it prevents their rusting (sodium bicarbonate and borax will do the same thing). It is used in washing clothes when a strong alkali is desired. (“Washing soda” is a term applied to sodium carbonate containing 10 molecules of water of crystallization.) MATERIA MEDICA AND THERAPEUTICS 193 Average dose: 0.25 Gm. or 4 grains. Sodii Chloridum, Sodium Chloride (Common Salt), NaCl, U. S. P.—It contains, when dried to constant weight at 110° C., not less than 99.5 per cent of pure NaCl. Preserve it in well-closed containers. Properties ; It occurs as colorless, cubical crystals, or white crystalline pow- der, odorless, and having a saline taste. Its aqueous solution is neutral to litmus. It is very soluble in water, fairly soluble in glycerin, and slightly soluble in alcohol. Its solubility in water is not increased by heating the water. Preparation: It occurs in the native state as rock salt in large deposits throughout the world. Sea water contains about 3 per cent of this salt mixed with other salts. The waters of Great Salt Lake in Utah contain about 20 per cent of NaCl. It must be purified and freed from other salts before it is fit for medicinal or domestic use. Action and Uses : A tablespoonful to a glassful of tepid water is used as an emetic. As a condiment it is almost a daily necessity in the human economy. It is found in all fluids and tissues of the body. A weak aqueous solution is used as a gargle and nasal douche. It is used in the preparation of physi- ological solution of sodium chloride, U. S. P. This solution contains in every 1,000 cc, 8.5 Gm. of sodium chloride, and is commonly known as normal salt solution. While usually used in this strength solutions up to 21 per cent may be given if necessary. Nearly all drugs that are injected into the system, either hypodermically or intravenously, are dissolved in physiological salt solution, or one slightly weaker, in order that they will be isotonic (same salt density as the blood) when injected into the circulation. Average dose: 15 Gm. or 240 grains dissolved in warm water as an emetic. Liquor Sodii Chloridi Physiologicus, Physiological Solution of Sodium Chloride (Physiological Salt Solution, Normal Salt Solution), U. S. P.— Sodium chloride 8. 5 Gm. Distilled water, a sufficient quantity To make 1000. 0 cc. Dissolve the sodium chloride in sufficient freshly distilled water, neutral to litmus paper, to measure 1,000 cc, and filter, returning the filtrate until free from foreign particles. Transfer the solution to a sterile flask of insoluble glass having a capacity of about 1,000 cc, and stopper with a plug of purified, non- absorbent cotton, wrapped in gauze. Fasten stout, nonabsorbent paper or tin- foil over the top of the cotton and the lip of the container, and sterilize in an autoclave under steam pressure, maintaining a temperature of not less than 115° C. for 30 minutes. This solution must be protected from contamination and should be used intravenously within 24 hours after its preparation and sterilization. Sodii Citras, Sodium Citrate, U. S. P.—It contains not less than 99 per cent of C3H4.(OH) .(COONa)s and not less than 10 per cent nor more than 13 per cent of water. Preserve it in well-closed containers. Properties: Occurs as a white granular powder, odorless, and having a cooling saline taste. It is very soluble in water, and is insoluble in alcohol. An aqueous solution is slightly alkaline to litmus. It has the property of holding in solution certain insoluble substances, a property possessed by other alkaline citrates. Preparation ; It is made by the action of citric acid on sodium carbonate, 2CsH4(OH) (C00H)3+3Na3C03=2C3H(0H) (C00Na)3+3C02+3H20. 194 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY Action and Uses : An aqueous solution has the property of preventing coag- ulation of the blood and delaying the curdling of milk. A solution containing 2 grains of sodium citrate and 20 grains of sodium chloride to 1 fluidounce of water (Wright’s solution) is used for the irrigation of wounds and as a local application for furunculosis. For modifying cow’s milk in infant feeding to prevent the formation of large curds, 1 grain of sodium citrate to 1 fluid- ounce of milk may be used. Its action in preventing coagulation of the blood and delaying milk curdling is supposed to be due to the formation of calcium citrate, which does not ionize and is therefore inactive. It is used in Pharmacy as a buffer agent. Average dose: 1 Gm. or 15 grains. Sodii lodidum, Sodium Iodide, U. S. P.—It contains not less than 99 per cent of Nal. Properties : Colorless, odorless crystals, or a white, granular powder. In moist air it cakes and then deliquesces, and frequently undergoes decompo- sition, developing a brown tint. It is very soluble in water, alcohol, and glycerin. It should be preserved in airtight containers. Action and Uses: It has the same action as potassium iodide but is less irritating to the stomach. The “iodized table salt” sold in the United States contains 0.1 Gm. of sodium iodide in each 1,000 Gm. of sodium chloride. Average dose: 0.3 Gm. or 5 grains. Sodii Perboras, Sodium Perborate, U. S. P.—It contains not less than 9 per cent of available oxygen, corresponding to about 86.5 per cent of NaB03.4H20. Preserve it in well-closed containers. Properties: It occurs as white, crystalline granules or as a white powder. It is odorless and has a saline taste. It is stable in cool dry air, but is de- composed with the evolution of oxygen in warm or in moist air. One gram is soluble in 40 cc of water. In aqueous solution sodium perborate is decom- posed into sodium metaborate and hydrogen peroxide, the solution gradually evolving oxygen. Oxygen is evolved more rapidly if the solution is warm. A saturated aqueous solution is alkaline to litmus paper. Action and Uses: It is used as a cleansing mouth antiseptic. It is used in tooth pastes, tooth powders, and mouth washes. Solutions of sodium per- borate should be prepared fresh as they easily decompose on standing. Average dose: 0.06 Gm., or 1 grain. Sodii Phosphas, Sodium Phosphate, Na2HP04-f 7H20, U. S. P.—It contains, when dried to constant weight at 110° C., not less than 98 per cent of Na2HP04. It contains not less than 43 per cent and not more than 50 per cent of water. Preserve it in well-closed containers in a cool place. Properties : Occurs as a colorless or white, granular salt, efflorescent in warm, dry air. It is very soluble in water and slightly soluble in alcohol. An aqueous solution is alkaline to litmus. If sodium phosphate is stored in a warm store- room, much of the water of crystallization separates and the sodium phosphate settles in the bottom of the bottle, forming a hard mass that cannot be removed without breaking the bottle. This hard mass, having lost most of its water of crystallization, is much stronger than the granular salt. Preparation: Sodium phosphate is made from the inorganic part of animal bones. Bones contain a large amount of calcium phosphate (Ca3(P04)2), which by a series of reactions is converted into sodium phosphate. Sodium phosphate, if not properly prepared, may contain arsenic as an impurity through the use of impure sulfuric acid in its manufacture. MATERIA MEDICA AND THERAPEUTICS 195 Action and Uses: It is used as a saline cathartic, acting much like mag- nesium sulfate. It is administered dissolved in warm water and given before breakfast. It is considered an excellent remedy in catarrhal jaundice and chronic gastric catarrh. Average dose: 4 Gm. or 60 grains. Sodii Salicylas, Sodium Salicylate, NaCiHsOs, U. S. P.—It contains, when dried to constant weight at 100° C., not less than 99.5 per cent of pure CdL.OH.COONa. Preserve it in well-closed containers, protected from heat and light. Properties ; Occurs as a white powder, or scales, or an amorphous powder, colorless or with a faint pink tinge, odorless, and having a sweet saline taste. Soluble in 0.9 part of water, 9.2 parts of alcohol, and in 4 parts of glycerin. An aqueous solution is neutral or faintly acid to litmus. Preparation : It is prepared by mixing pure salicylic acid with sufficient distilled water to form a paste and then with pure, crystallized sodium car- bonate (uneffloresced), the reaction being: 2G;H4(OH)COOH-f-NaaCOs=2043-1 (OH) COONa+H20+COa. Action and Uses: It is used as an antirheumatic, analgesic, and antipyretic. It is a valuable remedy in the treatment of rheumatism, tonsillitis, and influ- enza. It should be given with sodium bicarbonate to prevent precipitation of salicylic acid by the hydrochloric acid in the stomach. Average dose: 1 Gm. or 15 grains. Sodii Thiosulfas, Sodium Thiosulfate (Hypo, Sodium Hyposulfite) NaaSaOs+SHaO, U. S. P.—It contains, when rendered anhydrous by drying to constant weight at 100° C., not less than 99 per cent of Na2S203. It contains not less than 32 per cent and not more than 37 per cent of water. Preserve it in well-closed containers. Properties : Occurs as large, colorless crystals or a coarse crystalline powder. It is permanent in the air below 33° C., but effloresces in dry air above that temperature; deliquescent in moist air. Soluble in 0.5 part of water and insoluble in alcohol. When an aqueous solution is boiled the salt is decomposed rapidly. When brought in contact with a solution of iodine it immediately decolorizes the iodine, forming new compounds. It is capable of dissolving the halogen compounds of silver, as ; AgBr-fNa2S203=NaAgS203-l-NaBr. An aqueous solution is faintly alkaline to litmus paper. Preparation : It can be made by treating calcium thiosulfate with sodium car- bonate, CaS203+Na2C03—CaC03+Na2S203. Action and Uses: An aqueous solution of 1 in 10 may be used for various parasitic diseases of the skin. In the absence of starch it may be used for iodine poisoning. An aqueous solution is the best agent for removing iodine stains from linen. It is used extensively in photography as a fixing bath. Average dose: 1 Gm. or 15 grains. Sodii Sulfas, Sodium Sulfate (Glauber’s Salt), U. S. P.—When rendered anhy- drous by drying at 120° C. it contains not less than 99 per cent of Na2S04. It contains not less than 51 per cent and not more than 57 per cent of water. Preserve it in well-closed containers. Description : Large, colorless, odorless, transparent crystals or a granular powder. The salt effloresces rapidly in the air. One Gm. is soluble in 1.5 cc of water. It is insoluble in alcohol but is soluble in glycerin. It liquefies in its water of hydration at about 33° C., and at 100° 0. it loses all of its water of hydration. An aqueous solution of the salt is neutral to litmus paper. 196 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Action and Uses : It is used as a saline cathartic. It is sometimes given with other salts. See Artificial Carlsbad Salt, N. F. Average dose: 15 Gm. Liquor Sodii Hypochloritis, Solution of Sodium Hypochlorite, U. S. P.— Caution : This solution is not suitable for application to wounds. Description : A clear, pale, greenish-yellow liquid, having a slight odor of chlorine. The solution first colors red litmus paper blue and then bleaches it. The addition of diluted hydrochloric acid to the solution causes evolution of chlorine. Preserve it in well-stoppered bottles in a cool place protected from light. Action and Uses: This solution is used in preparing the Diluted Solution of Sodium Hypochlorite, U. S. P. Liquor Sodii Hypochloritis Dilutus, Diluted Solution of Sodium Hypochlorite, U. S. P.—An aqueous solution of chlorine compounds of sodium containing in each 100 cc not less than 0.45 Gm. and not more than 0.50 Gm. of NaOCl, equivalent to not less than 0.43 Gm. and not more than 0.48 Gm. of available chlorine when prepared as directed in the U. S. P. Description: A colorless or faintly yellow liquid having a slight odor sug- gesting chlorine. Preserve it in well-stoppered bottles in a cool place pro- tected from light. Action and Uses : This is Modified Dakin’s Solution. It is used for continu- ous irrigation of infected founds. This solution can also be prepared by passing chlorine gas through a solution of sodium carbonate. Aqua Ammoniac Fortior, Stronger Ammonia Water, U. S. P.—An aqueous solution of ammonia (NH3) containing not less than 27 per cent nor more than 29 per cent by weight of NH3. This solution deteriorates rapidly in open con- tainers. Preserve it in a cool place in glass-stoppered or rubber-stoppered bottles made of hard glass, free from lead. Great caution should be used in handling this liquid because of its caustic and irritating properties and it must never be tasted or smelled unless very greatly diluted. Properties : It has an excessively pungent, characteristic odor and a very caustic and alkaline taste. In its chemical properties it closely resembles the solutions of potassium or sodium hydroxide, being a strong, caustic alkali. If kept in a warm place, ammonia (NHS) is liberated and held in the upper part of the bottle; therefore great care should be exercised in opening the bottle to see if the stopper has been secure and has not allowed the gas to escape. There is danger of the sudden escape of a large amount of gas, which might cause injury to the eyes or mucous membranes of the nose and throat by inhalation. Preparation: Ammonia is a by-product in the manufacture of illuminating gas. When coal is subjected to destructive distillation ammonia is one of the products formed. The gases formed are passed through an acid solution (sul- furic or hydrochloric) and an ammonium salt is formed (ammonium sulfate or chloride, according to the acid used). This salt then is heated with lime, ammonia (NH3) is set free, and after passing it through quicklime it is passed into water until a saturated solution is formed. Action and Uses: Stronger ammonia water is never given internally. It is used in making the weaker solution of ammonia, known as ammonia water. Ammonia water is an aqueous solution of ammonia (NHS) containing not less than 9.0 grams nor more than 10.0 grams of NH3 in each 100 cc. This solution is used in making aromatic spirit of ammonia and ammonia liniment. The antidote for ammonia water is weak acids the same as for other alkaline hy- droxides. Inhalations of ammonia gas stimulate the heart and respiratory cen- 197 MATEEIA MEDICA AND THERAPEUTICS ter. CEdema of the glottis, resulting in obstructed breathing, might result in giving inhalations of concentrated ammonia gas; therefore care should be exercised in giving inhalations to an unconscious patient. Ammonii Chloridum, Ammonium Chloride (Sal Ammoniac, Ammonium Mu- riate), NH4CI, U. S. P.—It contains, when dried for 24 hours over sulfuric acid, not less than 99.5 per cent of NH4C1. Properties: It is soluble in 2.6 parts of water, 100 parts of alcohol, and 8 parts of glycerin. On heating it does not melt, but passes directly to the gaseous state. It occurs as colorless crystals or a white, crystalline powder, having a cool saline taste. It is somewhat hygroscopic. Preparation : It is chiefly made from gas liquor, the ammoniacal liquid ob- tained from gas works during the destructive distillation of coal in the manu- facture of illuminating gas, and neutralized with hydrochloric acid: NHs+ HC1=NH4C1. Action and Uses: It is a valuable stimulant expectorant and often is used in cough mixtures (Brown mixture with ammonium chloride). Large doses lower the alkali reserve of the blood and increase the acidity of the urine. Large doses irritate the stomach and must be given in capsules coated with stearic acid or other enteric coating. Average dose: 0.3 Gm. or 5 grains. Ammonii Carhonas, Ammonium Carbonate, U. S. P.—It consists of a mixture of acid ammonium carbonate (NH4HC03) and ammonium carbamate (NH4NH2 CO2) in varying proportions, and yields not less than 30 per cent nor more than 32 per cent of NH3. Preserve it in airtight containers in a cool place pro- tected from light. For medicinal purposes use only the translucent portions. Properties : It occurs in white, hard, translucent masses, having an ammo- niacal odor. On exposure to the air the salt loses both ammonia and carbon dioxide, becoming opaque, and finally is converted into friable, porous lumps or a white powder. It is soluble in 4 parts of water and is decomposed by hot water with the elimination of carbon dioxide and ammonia. Alcohol dissolves the carbamate, but leaves the acid ammonium carbonate. An aqueous solution is alkaline to litmus. Preparation : At present it is made principally by the sublimation of a mix- ture of ammonium sulfate and calcium carbonate, 2(NH4)2S04+2CaC03=2CaS04 +NH4HCa.NH4NH2C02-f-NH3+H20. Action and Uses: It is used in making aromatic spirit of ammonia and solution of ammonium acetate. It is a stimulant expectorant and heart stim- ulant, and is used in expectorant mixtures and smelling salts. It should never be given in powdered form because it is irritating. Mixed with an equal bulk of stronger ammonia water and scented with oil of lavender, it con- stitutes the common smelling salts. Average dose: 0.3 Gm. or 5 grains. Spiritus Ammoniac Aromaticus, Aromatic Spirit of Ammonia, U. S. P.—It con- tains in each 100 cc, not less than 1.7 Gm. and not more than 2.1 Gm. of total NH3; and ammonium carbonate, corresponding to not less than 3.5 Gm. and not more than 4.5 Gm. as (NH4)2C03. Preserve it in glass-stoppered bottles, in a cool place and protected from light. Description: A nearly colorless liquid when freshly prepared, but gradually acquiring a yellow color on standing. It has the taste of ammonia, and an aromatic and pungent odor. Action and Uses : It is used as a reflex stimulant to prevent fainting, and to relieve nausea or sick headache caused by hyperacidity of the gastric juice. 198 HANDBOOK OF THE HOSPITAL CORPS, 17. S. NAVY It should be given well diluted with water. It contains from 62 to 68 per cent of alcohol. Average dose: 2 cc or 80 minims. The alkaline earth elements and their compounds, The alkaline earth elements are magnesium, calcium, strontium, and barium. They are called alkaline earth elements because their oxides have marked alka- line (basic) properties, and the compounds of these elements are found abund- antly in the earth. They are all divalent and are strongly electropositive. Their compounds are not nearly as soluble as the compounds of the alkali elements; in fact, many of their compounds are insoluble in water. The hydroxides, carbonates, and sulfates (except magnesium sulfate) are insoluble or only slightly soluble in water. Their alkaline properties are not as intense as in the case of the alkali elements (sodium, potassium, lithium), and their hydroxides are classed as mild alkalies (milk of magnesia and lime water). Magnesium compounds. Magnesii Carbonas, Magnesium Carbonate, U. S. P.—Basic hydrated magne- sium carbonate, equivalent to not less than 39.2 per cent and not more than 41.5 per cent of MgO. Properties: It occurs as light, white, friable masses, or a white, bulky powder, odorless, and having a slight earthy taste. It is practically insoluble in water and alcohol. It is stable in the air. Preparation : It is made by mixing cold dilute solutions of magnesium sulfate and sodium carbonate: 5MgS04-l-5Na2C03H-H20=4MgC03.Mg(0H)2-f5Na2S04+ C02. Action anp Uses: It is used in making solution of magnesium citrate and magnesia magma. It is given internally as an antacid and as an antidote for acid poisoning. Average dose: 3 Gm. or 45 grains. Magnesii Sulfas, Magnesium Sulfate (Epsom Salt) MgS04.7H20, U, S. P.—It contains, when rendered anhydrous by ignition, not less than 99.5 per cent of MgSCh. It contains not less than 45 per cent and not more than 52 per cent of water. Preserve it in well-closed containers. Properties : It occurs as small, colorless needle-like prisms, without odor, and having a cooling, saline, and bitter taste. It is soluble in 0.8 part of water, almost insoluble in alcohol, and is slowly efflorescent in warm, dry air. Preparation: One of the methods of making magnesium sulfate is by the action of sulfuric acid on magnesium carbonate (mineral magnesite), MgCOs+ H2S04=MgS04+H20+C02. Action and Uses : It is an extensively used saline cathartic. It should be given before breakfast in a saturated aqueous solution. It acts both by pre- venting absorption of fluid from the bowel and by drawing more fluid from the blood into the intestine. Applied externally in saturated solution on lint to swollen joints in acute arthritis, to swollen testicles in orchitis, and to boils, it relieves pain and congestion by extracting fluid from these parts. It is the chemical antidote for poisoning by lead acetate, producing an insoluble lead sulfate, and is also used in phenol poisoning. Magnesium sulfate can be made more pleasant to take by mixing it with sodium bicarbonate, citric acid, and tartaric acid. This mixture is known as Effervescent Salt of Magnesium Sul- fate, N. F. Average dose: 15 Gm. or 4 drams. MATERIA MEDICA AND THERAPEUTICS 199 Magma Magnesias, Magnesia Magma (Milk of Magnesia), U. S. P.—It is an aqueous suspension of magnesium hydroxide containing not less than 7 per cent and not more than 8.5 per cent of Mg (OH) 2. For the purpose of mini- mizing the action of the glass container on Magnesia Magma, 0.1 per cent of citric acid may be added. One-half cc of a volatile oil or a blend of volatile oils suitable for flavoring purposes may be added to each 1,000 cc of Mag- nesia Magma. It should be stored in a cool place where the temperature is not above 35° C. It should not be permitted to freeze. Description: A white, opaque, more or less viscous suspension from which varying amounts of water usually separate on standing. It is alkaline to litmus and to phenolphthalein test solution. Action and Uses: It is used as an antacid and mild laxative and for other purposes for which magnesium oxide is used. Average dose: 4 cc or 1 fluidram as an antacid; 15 cc or 4 fluidrams as a laxative. Liquor Magnesii Citratis, Solution of Magnesium Citrate, U. S. P.—It contains in each 100 cc an amount of magnesium citrate corresponding to not less than 1.6 Gm. and not more than 1.9 Gm. of MgO. Description: A slightly yellow, clear, effervescent liquid, having a sweet, acidulous taste, and a lemon flavor. Keep the bottle on its side in a cool place, preferably in a refrigerator. Action and Uses: It is an agreeable saline purgative. Average dose: 200 cc or 7 fluidounces (1 glassful). Magnesii Oxidum Ponderosum, Heavy Magnesium Oxide (Heavy Magnesia), U. S. P.—Heavy Magnesium Oxide contains after ignition, not less than 96 per cent of MgO. Its loss in weight, during ignition, does not exceed 10 per' cent. Preserve it in well-closed, moisture-proof containers. Description; In the form of a white powder. It absorbs moisture and car- bon dioxide when exposed to the air. Action and Uses : Used as an antacid to neutralize excessive acidity in the gastric juice, or acidity due to fermentation in the intestines. It is a good antidote for corrosive acid poisoning. Average dose: 0.25 Gm. or 4 grains as an antacid; 3.0 Gm. or 45 grains as a laxative. Talcum Purificatum, Purified Talc, U. S. P.—A purified, native, hydrous mag- nesium silicate, sometimes containing a small amount of aluminum silicate. Properties : It is a very fine white or grayish-white crystalline powder which adheres to the skin, free from grittiness and unctuous to the touch. When used as a filtering medium it should not be finer than No. 100 powder. Preparation; It is prepared by treating ordinary talcum with several wash- ings of diluted hydrochloric acid, which dissolves out aluminum, iron, and other salts of magnesium. Action and Uses: It forms the base of nearly all cosmetic powders. It is an excellent dusting powder, and is used in pharmaceutical operations as a filtering medium. When perfumed or medicated, or both, it is sold as talcum powder. Calcium compounds. Calx, Lime (Calcium Oxide, Quicklime), N. F.—When freshly ignited to con- stant weight with a blast lamp, it contains not less than 95 per cent of OaO. It loses not more than 10 per cent of its weight on ignition. Keep lime in air- tight containers, in a dry place. 200 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Description : Lime occurs in hard, white or grayish white masses or gran* ules or a white powder. It is odorless. One gram is soluble in 840 cc of water at 25° C. and in 1,740 cc of boiling water. It is soluble in glycerin and syrup, but is insoluble in alcohol. When moistened with water, lime becomes heated and is gradually converted into a white powder (calcium hydroxide or slaked lime). When this slaked lime is mixed with about three or four times its weight of water, it forms a smooth magma (milk of lime). Water when agitated with lime becomes alkaline to litmus paper. Action and Uses : Lime is used in making Solution of Sulfurated Lime, N. F. It may be used in making Lime Water, but the Pharmacopoeia now provides Calcium Hydroxide for this purpose. {See Calcium Hydroxide.) Quick-lime (lime) is used to disinfect excreta in outdoor toilets. Calcii Hydroxidum, Calcium Hydroxide (Slaked Lime), U. S. P.—Calcium hydroxide contains not less than 95 per cent of Ca(OH)2. Preserve it in airtight containers. Description : A soft, white crystalline powder, possessing an alkaline, slightly bitter taste. One gram of calcium hydroxide dissolves in 630 cc of water at 25° C., and 1 gram dissolves in 1,300 cc of water at the boiling temperature. It is soluble in glycerin and in syrup but is insoluble in alcohol. When mixed with about three or four times its weight of water, it forms a smooth paste (milk of lime). Action and Uses : It is used in making Solution of Calcium Hydroxide, U. S. P. Liquor Calcii Hydroxidi, Solution of Calcium Hydroxide (Lime Water), U. S. P.—Solution of Calcium Hydroxide is an aqueous solution containing in each 100 cc at 25° O., not less than 0.14 Gm. of Ca(OH)2. The content of calcium hydroxide varies with the temperature at which the solution is stored, being about 0.17 Gm. per 100 cc at 15° C., and less at a higher tem- perature. Preserve it in well-filled, tightly-stoppered bottles, in a cool place. Description ; A clear, colorless, odorless liquid with a sweetish, alkaline taste. The solution is strongly alkaline to litmus paper. It absorbs carbon dioxide from the air, a film of calcium carbonate forming on the surface of the liquid. When heated, it becomes turbid, due to the separation of calcium hydroxide. Calcium hydroxide is less soluble in hot water than in cold water. Action and Uses ; Lime Water is an antacid. It is added to milk to prevent formation of large curds in the stomach, 1 part of Lime Water to 4 parts of milk. It is an antidote for corrosive acid poisoning; however, because it is a very dilute solution, a very large amount would have to be given to neu- tralize a considerable amount of acid. Average dose: 15 cc or 4 fluidrams. Calcii Chloridum, Calcium Chloride, U. S. P.—Calcium Chloride is a hydrated salt, containing not less than 75 per cent and not more than 85 per cent of CaCl2. Preserve it in airtight containers. Description : White, slightly translucent, hard, odorless fragments or gran- ules. It is very deliquescent. One gram is soluble in 1.2 cc of water, and in about 10 cc of alcohol. An aqueous solution of the salt (1 in 20) is neutral or slightly alkaline to litmus paper. Action and Uses : In internal haemorrhage, certain bone diseases, and for lime deficiency anywhere in the body. Other salts of calcium are preferred for oral administration. It has been given intravenously in certain haemorrhagic conditions. Average dose: 1 Gm. or 15 grains. Greta Praeparata, Prepared Chalk, (Drop Chalk), U. S. P.—Prepared Chalk is a native form of calcium carbonate freed from most of its impurities by MATERIA MEDICA AND THERAPEUTICS 201 elutriation, and containing, when dried to constant weight at 200° C., not less than 97 per cent of CaCCh. Description : A white to grayish-white, micro-crystalline powder often formed into “conical drops”. It is odorless and tasteless, and is stable in the air. It is practically insoluble in water and is insoluble in alcohol. Action and Uses : It is used in the preparation of Mercury with Chalk, Chalk Mixture, and Compound Chalk Powder. Prepared Chalk possesses a stickiness causing it to adhere to irritated mucous surfaces of the intestinal tract. This property accounts for its preference for internal use over Precipitated Calcium Carbonate. It is a valuable antacid. It is used in tooth powders and pastes. It is a very good antidote for corrosive acid poisoning, particularly oxalic acid poisoning. Average dose: 1 Gm. or 15 grains. Calcii Carbonas Praecipitatus, Precipitated Calcium Carbonate (Precipitated Chalk), U. S. P.—Precipitated Calcium Carbonate, when dried to constant weight at 200° C., contains not less than 98 per cent of CaCo3. Description : A fine, white, micro-crystalline powder, without odor or taste. It is stable in the air. It is practically insoluble in water. Its solubility in water is increased by the presence of any ammonium salt and by the presence of carbon dioxide. It is insoluble in alcohol. Action and Uses: It is an antacid and detergent, but Prepared Chalk is pre- ferred for internal use. It is used in tooth powders. It is also used in dusting powders to neutralize acid secretions. It is the best Known antidote for poison- ing by oxalic acid. It is also a good antidote for poisoning by inorganic acids. Calcii Gluconas, Calcium Gluconate, U. S. P.—Calcium Gluconate is the normal calcium salt of gluconic acid. It yields not less than 12.4 per cent and not more than 12.8 per cent of CaO. Preserve in well-closed containers. Average dose : 1 Gm. or 15 grains. Description : A white, crystalline or granular powder. It is odorless, taste- less, and is stable in the air. One gram is slowly soluble in 30 cc of water. It is insoluble in alcohol. An aqueous solution (1 in 50) is neutral to litmus paper. Action and Uses: It increases the blood calcium. It is used in all calcium deficiencies. It is also used before surgical operations to lessen blood coagu- lation time. It may be given intravenously, and by mouth. Solutions of calcium gluconate are less irritating than the chloride and are preferred, for subcutaneous injection. Average dose: 5 Gm. or 75 grains, orally; 1 Gm. or 15 grains, intravenously. Calcii Lactas, Calcium Lactate, U. S. P.—Calcium Lactate is a hydrated salt containing not less than 25 per cent and not more than 30 per cent of water. When rendered anhydrous by drying to constant weight at 120° C., it contains not less than 98 per cent of (CH3.GH.OII.COO) 2Ca. Preserve it in well-closed containers. Description : A white, almost odorless powder. It is somewhat efflorescent and at 120° Co. becomes anhydrous. One gram is soluble in 20 cc of water. It is practically insoluble in alcohol. Action and Uses : It increases the blood calcium. It is used for the same purpose as the gluconate. Average dose: 1 Gm. or 15 grains. Barium compounds. Barii Sulfas, Barium Sulfate, U. S. P.—In directing the use of Barium Sulfate the title should always be written out in full to avoid confusion with the poisonous barium sulfide or sulfite. 202 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Description : A fine, white, odorless, tasteless, and bulky powder, free from grittiness. It is insoluble in water, in organic solvents and in aqueous solutions of acids and of alkalies. Action and Uses : It is used in making X-ray pictures of the stomach and intestine. It passes unchanged through the gastro-intestinal tract. It should be remembered that soluble salts of barium are poisonous. Barium Sulfate is nonpoisonous because it is insoluble in water or in the juices of the intestinal tract. The New and Nonofficial Remedies describes the method of admin- istration as follows: “For Roentgen Examination of the Stomach.—The evening before the exam- ination, the patient receives 1 fluidounce of castor oil. In the morning an ordinary portion of wheat-meal porridge, with which 2 ounces of barium sulfate has been well mixed, together with a little sugar and cream, is admin- istered by mouth. The patient is then directed to abstain from further food. The examination is made 6 hours later. “For Roentgen Examination of the Colon.—An enema consisting of 16 ounces of mucilage of acacia, 3 pounds of condensed milk, and 8 ounces of barium sulfate is warmed to body temperature and injected into the rectum from a height of from 3 to 6 feet (90 to 180 cm). The examination is made with a fluoroscope while the injection is passing into the rectum.” Zinc compounds. Zinci Oxidum, Zinc Oxide, ZnO, U. S. P.—It contains, when freshly ignited not less than 99 per cent of ZnO. Properties: It is a very fine, amorphous, white or yellowish-white powder, free from gritty particles, without odor or taste. It gradually absorbs carbon dioxide from the air; is insoluble in water or alcohol, but soluble in ammonia and ammonium carbonate test solutions, and in dilute acids. Preparation: It is made by calcination of pure zinc carbonate: 2ZnCOs. 3Zn (OH) 2+heat=5Zn0+3H20+2C02. Action and Uses: Zinc oxide is a nontoxic protective and is mildly astringent and slightly antiseptic. It may be employed either in the form of a dusting powder, in a paste, in an ointment, or suspended in an aqueous mixture. The most popular of these is zinc-oxide ointment, which is composed of 20 per cent zinc oxide, 10 per cent liquid petrolatum, 5 per cent wool fat, 5 per cent white wax, and 60 per cent white petrolatum. Zinci Sulfas, Zinc Sulfate (White Vitriol), ZnS04+7H20, U. S. P.—It contains not less than 55.86 per cent nor more than 58.63 per cent of zinc sulfate, corre- sponding to not less than, 99.5 per cent of the hydrated salt (ZnSCb+'iTELO). Preserve it in well-closed containers. Properties: It occurs in colorless, transparent prisms, or small needles, or as a granular, crystalline powder, odorless, and having an astringent and metallic taste. It is efflorescent in dry air. Soluble in 0.6 parts of water, 2.5 parts of glycerin, and insoluble in alcohol. An aqueous solution is acid to litmus paper. Preparation: Made by treating metallic zinc with, diluted sulfuric acid; Zn+H2S0*=ZnS04+H2. Action and Uses : It is employed as an astringent and emetic. A weak aqueous solution 1-400 may be used as an eye wash, gargle, or urethral injection in gonnorhoea. It acts as a prompt emetic in 15-grain doses but as other drugs are preferred, it seldom is used. It is used in the Navy prin- cipally as an astringent eye wash, 1 grain dissolved in 1 fluidounce of dis- tilled water. Average dose; 1 Gm. or 15 grains. (As an emetic.) MATERIA MEDICA AND THERAPEUTICS 203 Calamina Prseparata, Prepared Calamine, N. F.—Prepared Calamine is zinc oxide with a small amount of ferric oxide, and contains, after ignition, not less than 98 per cent of ZnO. Description : Prepared Calamine is a pink powder which will pass through a number 100 sieve. It is odorless and almost tasteless. It Is insoluble in water but dissolves almost completely in mineral acids. Action and Uses : It is mildly astringent and soothing when applied to the inflamed skin. It is used in ointments, lotions, and powders. Zinci Chloridum, Zinc Chloride, U. S. P.—Zinc Chloride contains not less than 95 per cent of ZnCh. Preserve it in glass-stoppered bottles. Description : A white, or nearly white, odorless, crystalline powder, or in porcelain-like masses, or molded into pencils. It is very deliquescent. One gram is soluble in 0.25 cc of water, and in about 1.3 cc of alcohol. It is soluble in 2 parts of glycerin. An aqueous solution of the salt (1 in 10), is acid to litmus paper. Solutions of Zinc Chloride when diluted with much water become turbid, owing to hydrolysis. This turbidity disappears upon the addition of a small quantity of hydrochloric acid. Action and Uses: It is antiseptic, astringent, and escharotic. Solution of Zinc Chloride should be filtered through glass wool, because it dissolves paper filters. If an eye solution of zinc chloride becomes turbid it should not be cleared up with hydrochloric acid. The antidote for zinc chloride poisoning is sodium bicarbonate followed by milk or white of egg. A 1 to 2 per cent solution is used as a dental astringent and antiseptic. It is not given internally. Zinci Stearns, Zinc Stearate, U. S. P.—Zinc Stearate is a compound of zinc with variable proportions of stearic acid and palmitic acid, corresponding to not less than 13 per cent and not more than 15.5 per cent of ZnO. Description ; A fine, white, bulky powder, free from grittiness, and having a faint, characteristic odor. It is insoluble in water and in alcohol. Action and Uses: Used as an infant dusting powder but must be used with care to avoid inhalation of the fine dust,' which is toxic, causing inflammation of the baby’s lungs. It is also used in ointments. Aluminum compounds. Alumen, Alum, U. S. P.—It contains not less than 99.5 per cent of A1NH4 (S04)2+12H20; or A1K(S04)2+12H20. The label of the container must indi- cate whether the salt is ammonium alum or potassium alum. Properties : It occurs as large, colorless crystals, crystalline fragments, or as a white powder, odorless, and having a sweetish, strongly astringent taste. Soluble in 5.2 to 7.2 parts of water, insoluble in alcohol, and fairly soluble in glycerin. Potassium alum is more soluble in water than ammonium alum. An aqueous solution of alum is acid to litmus. Ammonium alum can be distinguished from potassium alum by heating a small quantity of a sample with lime. If it is ammonium alum, ammonia will be set free from the mix- ture. When a hot concentrated solution of alum is poured into a hot concen- trated solution of an alkaline carbonate the carbonate is decomposed with the liberation of C02 (similar to the action of an acid on a carbonate). This reaction is taken advantage of in the manufacture of cheap baking powders; alum mixed with sodium bicarbonate is mixed with the dough used in making bread. When the dough begins to bake the reaction starts, liberating C02 which, in rising, carries the dough with it for a certain distance. 154294°—39 14 204 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Preparation: Made principally from aluminum clay (silicate) by treat- ment with sulfuric acid and then adding potassium or ammonium sulfate, forming the double salt. Action and Uses: It is used as an astringent both internally and externally. Used as a local styptic in epistaxis, external haemorrhages and bleeding from mucous membranes, to which the powder can be applied drectly. In nosebleed a saturated solution on pledgets of cotton sometimes is used in the nares. Barbers use it for bleeding caused by shaving. When powdered it is used as an emetic. Alum is used in making exsiccated alum U. S. P. (burnt alum), which is alum deprived of its water of crystallization. The properties of exsic- cated alum are the same as those of alum except that they are more intensified. Average dose: 0.5 Gm., or 8 grains. Alumen Exsiccatum, Exsiccated Alum (Burnt Alum), U. S. P.—Exsiccated Alum, when recently dried to constant weight at 200° C., contains not less than 96.5 per cent of Ammonium Alum (A1NH4(SO<)*) or of Potassium Alum (AIK(864)2). The label of the container must indicate whether the Exsiccated Alum was m'ade from Ammonium Alum or Potassium Alum. Preserve it in airtight containers. Description : A white, odorless power. It has a sweetish, astringent taste, and absorbs moisture on exposure to air. Action and Uses : It is almost twice as strong as Alum, U. 8. P., which contains water of crystallization. Its astringent and caustic action is due largely to its great affinity for water. It is used by barbers to stop bleeding caused by razor cuts. It is not given internally. Iron compounds. Iron forms two series of chemical compounds, in one of which it has a valence of three and the compounds are known as ferric; in the other it has a valence of two and the compounds are known as ferrous. The ferric compounds are distinguished by their brown color, the ferrous compounds are green. The ferric compounds are fairly stable; the tendency of the ferrous compounds is to change to the ferric condition, especially in the presence of oxidizing agents. The ferric compounds are oxidizing agents; the ferrous compounds are reducing agents. Ferrous compounds are made by the action of an acid on an electronegative element, such as iodine, on metallic iron, excluding the air (oxygen), which is an oxidizing agent, to prevent oxidation to the ferric state. Ferric compounds are made by oxidizing ferrous compounds. The principal effect of iron on the system is that it increases the amount of hsematin in the haemoglobin of the blood resulting in an improvement in the functions of the various organs of the body, to which its tonic effect is due. Both locally and internally iron acts as an astringent. The astringent properties of the different compounds vary, some being very active while others are very mild. Most of the compounds of iron are soluble in water. The oxide, hydroxide, and carbonate are insoluble. Tinctura Ferri Chloridi, Tincture of Ferric Chloride (Tincture of Iron), U. 8. P.—A hydroalcoholic solution containing in each 100 cc, about 13 per cent of ferric chloride (FeCU), corresponding to not less than 4.5 per cent of Fe. Protect tinc- ture of ferric chloride from light, in a cool place, in glass stoppered bottles. Properties: A bright, amber-colored liquid, having a slightly ethereal odor, a very astringent, styptic taste, and an acid reaction. Preparation ; It is made by diluting 850 cc of solution of ferric chloride with sufficient alcohol to make 1,000 cc. Action and Uses: It should be administered well diluted with water, and taken through a glass tube. The mouth should be thoroughly rinsed to avoid Materia medica a ad therapeutics 205 injury to the teeth. It is a valuable chalybeate (iron) tonic and styptic. It also has slight diuretic properties. It is used in making solution of iron and ammonium acetate (Basham’s mixture), N. F. Average dose: 0.5 to 2 cc or 8 to 30 minims. Tincture of Ferri Citrochloridi, Tincture of Ferric Citrochloride (Tasteless Tincture of Ferric Chloride, Tasteless Tincture of Iron), N. F.—It is a hydroal- coholic solution made by dissolving sodium citrate in solution of ferric chloride and adding a small amount of alcohol and much water. It resembles in proper- ties the scale salts of iron, except that it is a solution. It contains, in each 100 cc, ferric citrochloride equivalent to not less than 4.48 Gm. of Fe. Action and Uses: It is used in making Elixir of Iron, Quinine, and Strych- nine, N. F. Its medicinal properties are practically the same as those of tincture of ferric chloride, U. S'. P., except that it is milder. Magma Ferri Hydroxidi, Magma of Ferric Hydroxide (Arsenic Antidote), U. S. P.—This preparation is used only as a chemical antidote for poisoning by arsenic. Average dose: 0.5 cc, or 8 minims. Preparation : Forty cc of Solution of Ferric Sulfate is mixed with 125 cc of distilled water and placed in a large, well-stoppered bottle. Ten Gm. of Mag- nesium Oxide is rubbed with cold water to a smooth, thin mixture, placed in a bottle capable of holding 1,000 cc, and 750 cc of distilled water then added. When needed, shake the mixture of magnesium oxide to a thin, creamy consist- ence, slowly add the diluted solution of ferric sulfate, and shake together until a uniformly smooth mixture results. A solution of Sodium Carbonate or Milk of Magnesia added to Tincture of Ferric Chloride, and the precipitate strained through cheesecloth, may be used if the official antidote is not available. Action and Uses : The antidotal action of this preparation is presumably due to the adsorption of arsenic. It is efficient only when freshly prepared, and, as it must be administered promptly, the two solutions should always be on hand ready for use. Piluae Ferri Carbonatis, Pills of Ferrous Carbonate (Bland’s Pills), U. S. P.— Each pill contains not less than 0.06 gram (1 grain) of FeCOa. Average dose: 120 cc or 4 fluidounces. Preparation : Made by the action of potassium carbonate on ferrous sulfate, FeS04+K2C0a=FeCO3+K2S04. The pills do not keep unless well coated to exclude oxygen. If kept on hand for a long time the ferrous carbonate is changed to the ferric state. When these pills are made in the dispensary they should be used as soon as possible after their preparation. They never should be prepared and kept in stock for issue, or dispensed if they are reddish-brown in color within. These pills are on the Supply Table, in tablet form, chocolate coated. Action and Uses: Valuable iron tonic. Used in the treatment of anaemias. Average dose: 3 pills. Ferri et Ammonii Citrates Virides, Green Iron and Ammonium Citrates, U. S. P.—Green iron and Ammonium Citrates contains ferric citrate equivalent to not less than 14.5 per cent and not more than 16 per cent of Fe. Preserve it in well-closed containers and protected from light. Description: Thin, transparent, green scales or granules. It is odorless and has a saline, mildly ferruginous taste. It is deliquescent in air, readily soluble in water, and insoluble in alcohol. An aqueous solution of the salt (1 in 20) is acid to litmus paper. Action and Uses: It is a suitable compound of iron for hypodermic adminis- tration. Average dose: 0.015 to 0.1 Gm. or 14 to 1% grains. (By parenteral injection.) 206 HANDBOOK OF THE HOSPITAL CORPS, tf. S. NAVY Arsenic compounds. Arseni Trioxidum, Arsenic Trioxide (White Arsenic), U. S. P.—When dried to constant weight at 100° C., it contains not less than 99.8 per cent of AS2O3. Pow- dered Arsenic Trioxide when administered in solid form, as in powders, tablets, and pills must consist of particles not greater than 0.0125 mm. in diameter. Properties: A white powder, or irregular masses of two varieties, one amorphous, transparent and colorless, like glass; the other crystalline, opaque and white, resembling porcelain. Frequently the same piece has an opaque, white outer crust enclosing the glassy variety. Contact with moist air gradu- ally changes the glassy into the white, opaque variety. All varieties are odorless. It is slowly soluble in water, freely soluble in glycerin, and slightly soluble in alcohol. It is dissolved by hydrochloric acid and by solutions of alkali carbonates. Caution : Arsenic trioxide is extremely poisonous. Actions and Uses : It irritates the mucous membrane of the stomach and intestine. Toxic doses cause nausea, vomiting, colicky pains in abdomen, watery diarrhoea, fatty degeneration of the liver and other organs. Large doses pro- duce great depression and collapse. It is thought that arsenic stimulates the action of the blood-forming organs, especially the bone marrow, and for this reason is considered useful in the treatment of anaemia. Some skin conditions such as psoriasis and chronic eczema are apparently improved by proper doses of arsenic. The physiological effect of arsenic is due to the arsenic trioxide ion and not to the element arsenic. In cases of poisoning, wash out the stomach and give large doses of Magma of Ferric Hydroxide, U. S. P. Average dose: 0.002 Gm. or %o grain. liquor Potassii Arsenitis, Solution of Potassium Arsenite (Fowler's Solution), U. S. P.—An aqueous solution of potassium arsenite containing in each 100 cc the equivalent of not less than 0.950 Gm. nor more than 1.050 Gm. of AS2O3. Pre- serve the solution in amber-colored bottles. Properties: A clear, colorless liquid, alkaline to litmus. Preparation ; It is made by boiling together potassium bicarbonate and arsenic trioxide in the proportion to give a finished solution having the given strength. It is held that the following reaction takes place: AS2O3-fIKHCCb = 2K2HASO3+H2O+4CO2. Action and Uses: It is a useful remedy against protozoal affections. Used in the treatment of malaria and relapsing fever; in the treatment of certain chronic skin affections such as psoriasis, lichen planus, chronic eczema, chronic urticaria, etc. It stimulates the action of the blood-forming organs, especially the bone marrow, by its alterative and tonic properties. It is a poison and must he handled with great care. Average dose: 0.2 cc or 3 minims, diluted with water. Arsphenamina, Arsphenamine (Diaminodihydroxyarsenobenzol hydrochloride), U. S. P.—Also known as salvarsan, 606, arsenobenzol and arsaminol. Contains not less than 30 per cent of arsenic (As). Its manufacture is under the control of the U. S. Public Health Service. Properties: A light yellow, hygroscopic powder, very unstable in air, and put up in sealed ampules. Action and Uses: A specific remedy for syphilis in all stages, but it is more efficient the more recent the infection; also useful in various spirillum diseases, such as relapsing fever, Vincent’s angina, etc. Average dose: 0.3 to 0.6 Gm. or 5 to 9 grains, administered intravenously. Neoarsphenamina, Neoarsphenamine (Neosalvarsan), U. S. P.—The name ap- plied to a mixture, sodiumdiaminodihydroxyarsenobenzenemethanolsulfoxylate MATERIA MEDICA AND THERAPEUTICS 207 with inert, inorganic salts. It contains not less than 19 nor more than 22 per cent of arsenic (As) and complies with the requirements of the National Institute of Health, U. S. Public Health Service. Preserve it in sealed tubes of colorless glass, from which the air has been excluded either by the production of a vacuum or by displacement with a nonoxidizing gas, in a cool place, prefer- ably not above 10° C. Action and Uses: Essentially the same as those of arsphenamine, although many observers claim better results. It differs from arsphenamine in that it dissolves readily in sterile water, making a neutral solution which can at once be injected. Water not warmer than from 20° to 22° C. (68° to 71.6° F) should be used in dissolving the drug and the injections should be made at once, as it oxidizes rapidly and becomes toxic. The solution should not be shaken and it must not be administered subcutaneously. Properties : A yellow powder, and is very unstable in air. Average dose: 0.6 to 0.9 Gm. or 9 to 14 grains. Tryparsamidum, Tryparsamide, U. S. P.—It contains not less than 25.1 and not more than 25.5 per cent of arsenic (As) when dried to constant weight at 110° G. Properties : A white, odorless, crystalline powder. One gram is soluble in 2 cc of water. It is slightly soluble in alcohol. It should be preserved in well- closed containers protected from light. The arsenic in this compound is penta- valent (having a valence of five). Action and Uses : It is used in the treatment of syphilis of the central nerv- ous system where arsphenamine and neoarsphenamine have failed to produce favorable results. It is given intravenously, intramuscularly, or subcutane- ously dissolved in distilled water or salt solution. It was first used in the treatment of trypanosomiasis. Average dose: 2 Gm. or 30 grains (Caution: Never give by mouth). The directions on the package should be followed in its administration. Sulfarsphenamine, N. N. R.—It contains 19 to 24 per cent of arsenic in the trivalent form. Properties : It is an orange-yellow powder possessing an odor resembling that of sulfur dioxide and arsine. It is readily soluble in water yielding a yel- low solution which is acid to litmus. Action and Uses: It is used in the treatment of syphilis where it is desired to administer arsenicals intramuscularly. It may also be given by subcutaneous injection. Average dose: 0.4 Gm. or 6 grains (intramuscularly). Antimony compounds. Antimonii et Potassii Tartras, Antimony and Potassium Tartrate (Antimonyl Potassium Tartrate, Tartrated Antimony, Tartar Emetic), U. S. P.—It contains not less than 99 per cent of KOOC.CHOH.CHOH.COO(SbO)+V2H2O. Preserve it in well-closed containers. Properties: Occurs as a white, granular powder or colorless, transparent crystals. Disagreeable metallic taste, odorless. The crystals effloresce on ex- posure to air. Soluble in 12 parts of cold water, 3 parts of boiling water, 15 parts of glycerin, and insoluble in alcohol. Its aqueous solution is slightly acid to litmus paper. Preparation ; It is made by boiling antimony oxide with potassium bitartrate. 2KHC4IUO6+Sb=03=2K (SbO) C*H«0«+HaO. Action and Uses: It is used chiefly as an expectorant and a diaphoretic, rarely as an emetic, and is of value in African sleeping sickness. It is one 208 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of the ingredients in Compound Mixture of Opium and Glycyrrhiza, U. S. P. (Brown Mixture). Average dose: 0.003 Gm. or %o grain. Bismuth compounds. Bismuthi Subnitras, Bismuth Subnitrate, U. S. P.—A basic bismuth nitrate of varying chemical composition, which, when dried for 24 hours in a desiccator over sulfuric acid, yields, upon ignition, not less than 79 per cent of bismuth oxide (Bi2Oa). Preserve it in well-closed containers protected from light. Properties: A heavy white powder, odorless, tasteless, and slightly hygro- scopic. Almost insoluble in water and insoluble in alcohol, readily soluble in hydrochloric or nitric acid. It is slightly acid in reaction. Preparation : It is made by dissolving metallic bismuth in nitric acid and treating the resulting solution with sodium carbonate which precipitates the bismuth as subcarbonate (here the bismuth is freed from arsenic) ; the sub- carbonate is redissolved with nitric acid, forming bismuth nitrate, which is converted to the subnitrate by treatment with ammonia water; the precipitate then is collected, washed, and dried. Action and Uses : It is used internally in the treatment of gastric and intes- tinal disorders as a sedative astringent, especially in diarrhoea and putre- factive conditions. In large doses it coats the mucous membranes of the intestine and acts as a protective. Very large doses are given in X-ray work for the purpose of outlining the stomach and intestine. However, bismuth sub- carbonate is better than the subnitrate for this purpose because it is less toxic. When applied to wounds or mucous membranes it acts as a protective, astrin- gent, and antiseptic. It is also given by parenteral Injection in the treatment of syphilis. Average dose: 1 Gm. or 15 grains; 0.125 Gm. or 2 grains as antisyphilitic. Bismuthi Suhcarhonas, Bismuth Subcarbonate (Basic Bismuth Carbonate), U. S. P.—It is a basic salt, which, when dried to constant weight at 100° C., yields upon ignition not less than 90 per-cent of Bi203. Protect it from the light in well- closed containers. Properties : A white or pale yellowish-white powder. It is odorless and taste- less, and is stable in the air. It is insoluble in water and in alcohol. Action and Uses : It is protective, slightly antiseptic, astringent, and ant- acid. It is used in the treatment of hyperacidity of the stomach and in the treatment of ulcers of the stomach and intestine. It is used in making X-ray pictures of the intestinal tract. It is less toxic than the subnitrate and may be given in larger doses with greater safety. It is used as an antiseptic and protective application in the treatment of skin diseases, old ulcers, and sup- purating wounds. Its external application to the broken skin must be watched for possible toxic symptoms due to absorption of the drug. Average dose: 1 Gm. or 15 grains. Bismuthi Subsalicylas, Bismuth Subsalicylate (Basic Bismuth Salicylate), U. S. P.—It is a basic salt containing not less than 62 per cent and not more than 66 per cent of BizOs when dried to constant weight at 100° C. Preserve it in well-closed containers protected from light. Properties ; A white, or nearly white, amorphous or crystalline powder. It is odorless and is stable in the air. It is practically insoluble in water. Action and Uses : It is given intramuscularly in the treatment of syphilis. It is administered suspended in oil. The preparation on the Supply Table known as Bismuth Subsalicylate in Oil contains 0.13 Gm. of Bismuth Sub- salicylate in each cubic centimeter of the mixture when thoroughly mixed by shaking. The oil is composed of 10 per cent camphor, 10 per cent creosote, and MATERIA MEDICA AND THERAPEUTICS 209 80 per cent olive oil. One cubic centimeter of this mixture is given each week until eight doses have been given. Average dose: 0.125 Gm. or 2 grains (intramuscularly). Bismuthi et Potassii Tartars, Bismuth and Potassium Tartrate, U. S. P.—It is a basic bismuth potassium bismuthotartrate containing the equivalent of not less than 71 per cent and not more than 75 per cent of BisOa. Preserve it in well- closed containers protected from light. Properties : A granular, white, odorless powder, having a sweetish taste. It darkens on exposure to light. One grain is soluble in 2 cubic centimeters of water. Action and Uses: It is given intramuscularly in the treatment of syphilis. A similar preparation is on the Supply Table by the name “Solution of Potas- sium and Sodium Bismuthotartrate (Bismosol)”. Average dose: 0.15 Gm. or 2grains (intramuscularly). Thio-Bismol, Sodium Bismuth Thioglycollate, N. N. R.—A salt formed by the interaction of sodium thioglycollate and bismuth hydroxide. It contains about 38 per cent of bismuth. Properties; It is a canary yellow, hygroscopic, noncrystalline but granular substance possessing a garlic-like odor. It is freely soluble in water but the solutions are not stable. It is on the Supply Table in the form of a 0.2 Gm. ampule which is to be dissolved in 1 cubic centimeter of sterile distilled water before administration. Action and Uses : It is used in the treatment of syphilis. It is a water solu- ble compound, readily absorbable, and produces very little local injury when injected. Average dose; 0.2 Gm. or 8 grains, administered intramuscularly twice a week for a series of 12 doses. Lead compounds. Plumbi Acetas, Lead Acetate (Sugar of Lead), U. S. P.—It contains not less than 85.31 per cent nor more than 89.57 per cent of anhydrous lead acetate, corresponding to not less than 99.5 per cent of the hydrated salt (CHa.COOL Pb+3H20. Preserve it in well-closed containers. Properties: It occurs as colorless, shining, transparent prisms or plates, or heavy, white, crystalline masses, or granular crystals, faintly acetous odor, and is efflorescent and absorbs carbon dioxide from the air; therefore it must be kept in well-closed containers. It is soluble in 1.6 parts of water, about 30 parts of alcohol, and is freely soluble in glycerin. An aqueous solution is slightly alkaline to litmus. Preparation: It is made by adding lead oxide to acetic acid and gently heating the mixture until combination takes place. PbO-f 2HC2H302= Pb (C2H3O2) 2+H2O. Action and Uses: It is used internally combined with opium (lead and opium pill containing 1 grain each), as a sedative astringent in diarrhoea. It is used in the preparation of Lotion of Lead and Opium, N. F., which is used externally as a sedative astringent application to sprains and bruises. A 1 per cent solution in alcohol is used externally for ivy poisoning. It is a very poisonous drug. The best antidote is magnesium sulfate which forms with the lead acetate an insoluble lead sulfate. The lead sulfate so formed must he washed out of the stomach with a stomach tube. Average dose: 0.06 Gm. or 1 grain. Mercury compounds. Hydrargyrum, Mercury (Quicksilver), Hg, U. S. P.—It contains not less than 99.5 per cent of Hg. Preserve it in strong, well-closed containers. 210 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Properties : A shining, silver-white, metal, liquid at ordinary temperatures. It solidifies at —38.8° O. and boils at 358° C. Its specific gravity is 13.596. Insoluble in ordinary solvents, but readily soluble in nitric acid. Mercury forms two series of compounds; Mercurows, in which mercury has a valence of one, and merur/c, in which it has a valence of two. Preparation: It is made by roasting sulfide of mercury (cinnabar), form- ing mercury and sulfur dioxide. Action and Uses : In its massive form mercury has very little action on the system, but when reduced to a fine state of subdivision it is capable of absorption either by the skin or mucous membranes and produces the physiolog- ical effects of its salts. It is contained in a fine state of subdivision, diluted with various vehicles in the following preparations: Mercury with Chalk, U. S. P.; Mass of Mercury, U. S. P.; Strong Mercurial Ointment, U. S. P.; Mild Mercurial Ointment, U. S. P. Hydrargyrum Ammoniatum, Ammoniated Mercury (White Precipitate), HgNHaCl, U. S. P.—'It contains mercurammonium chloride (HgNH2Cl) corre- sponding to not less than 78 per cent nor more than 80 per cent of Hg. Pre- serve it in well-closed containers, protected from light. Properties : A white, amorphous powder, odorless, and having an earthy, afterwards styptic metallic taste; permanent in the air; insoluble in water or alcohol. Preparation ; Made by precipitating a solution of mercuric chloride with ammonia water. HgCl2+2NH40H=HgNH2Cl+2H20+NH4Cl. Action and Uses: Taken internally it acts as an irritant poison. It is used externally in the form of an ointment (from 2 to 10 per cent) in the treatment of parasitic skin diseases. It acts as an antiseptic and local stimulant. Hydrargyri Bichloridum, Mercury Bichloride (Corrosive Sublimate, Corro- sive Mercuric Chloride, Bichloride of Mercury), HgCl2, U. S. P.—When dried for 24 hours over sulfuric acid, it contains not less than 99.5 per cent of HgCl2. Preserve it in well-closed containers. Description ; Heavy, colorless, odorless crystals or crystalline masses, or a white powder. One gram is soluble in 13.5 cc of water, in 3.8 cc of alcohol, in about 12 cc of glycerin, and in 22 cc of ether. An aqueous solution of mercury bichloride (1 in 20) is acid to litmus paper, but becomes neutral upon the addition of sodium chloride. When heated it volatilizes. Caution : Mercury Bichloride is extremely poisonous. Action and Uses : As an antiseptic application to the skin it may be used in strengths varying from 1-1,000 to 1-5,000 dissolved in water. The injection of bichloride solution into body cavities or its application to raw surfaces should be done with great caution. When used for irrigation of the vagina it may be absorbed in sufficient quantity to produce poisoning. A solution of bichloride corrodes instruments. If an aqueous solution of bichloride is exposed to light it undergoes partial decomposition with precipitation of calomel. This may be prevented by the addition of a few drops of hydro- chloric acid or ammonium chloride. Bichloride in solution with potassium iodide is given by mouth and it is also injected intramuscularly in the treat- ment of syphilis. Poisoning by bichloride, taken by mouth, is treated by immediate administration of whites of eggs followed by emetic and washing out the stomach. See section on Toxicology. Average dose: 0.004 Gm. or Vis grain. Hydrargyri Chloridum Mite, Mild Mercurous Chloride, (Calomel, Mercurous Chloride, Protochloride of Mercury, Subchloride of Mercury), HgCl, U. S. P.— MATERIA MEDICA AND THERAPEUTICS 211 It contains, when dried to constant weight in a desiccator over sulphuric acid, not less than 99.6 per cent of HgCL Preserve it in well-closed containers, protected from light. Properties : It is a heavy, white, impalpable powder, turning yellowish white on being triturated with pressure; odorless, tasteless, and permanent in the air. Insoluble in water, alcohol, ether, or cold diluted acids. It should not contain the slightest trace of bichloride of mercury. It undergoes changes when exposed to light, or in contact with alkaline chlorides, bromides, or iodides, resulting in the production of mercuric salts which are toxic. Preparation : The process for making calomel is similar to that for making bichloride except that metallic mercury is added. Mercury, mercuric sulfate, and sodium chloride are heated together in a retort, resulting in the formation of calomel, which is sublimed and condensed in a separate container. Hg+ HgS04+2NaCl=2HgCl+Na2S0i. After sublimation the calomel is washed sev- eral times with distilled water to free it from bichloride of mercury. Action and Uses : Used externally as an antiseptic dusting powder and in ointments (33% per cent) as a venereal prophylactic. Internally it is used as an alterative, cathartic, and diuretic. When calomel is given for its pur- gative effect it should be followed from 4 to 6 hours after administration by a normal dose of Epsom salt. Average dose: Laxative 0.15 Gm. or 2.5 grains; alterative 0.015 Gm. or % grain. Hydrargyri Oxidum Flavum, Yellow Mercuric Oxide, U. S. P.—It contains, when dried to constant weight at 110° C., not less than 99.5 per cent of HgO. Preserve it in well-closed containers, protected from light. Properties : An orange-yellow, heavy, impalpable powder ; odorless and having a metallic taste; turns darker on exposure to light, and is almost insoluble in water; insoluble in alcohol. Preparation ; Made by precipitating a solution of mercuric chloride with sodium hydroxide: HgCl2+2Na0H=Hg0-j-H20+2NaCl. Action and Uses : It is not given internally. In the form of an ointment it is used in the treatment of inflammation of the eyelids. Yellow Mercuric Oxide Ointment, U. S. P., contains 1 per cent of mercuric oxide. Hydrargyri Salicylas, Mercuric Salicylate (Mercuric Subsalicylate), U. S. P.— A compound of mercury and salicylic acid containing not less than 54 per cent nor more than 59.5 per cent of Hg. Preserve it in well-closed containers protected from light. Properties : A wdiite or slightly yellow or slightly pink powder; odorless and tasteless; insoluble in water or alcohol. Soluble in warm solutions of alkali halides forming double salts. Preparation : It may be made by heating yellow mercuric oxide with salicylic acid and a little water until a white mixture results. Action and Uses : Used in the treatment of syphilis. It is given intramuscu- larly suspended in neutral oil (1 grain to 10 minims of oil). It possesses the advantage of being less irritant than the other salts of mercury, both to the intestinal tract and when given intramuscularly. It is absorbed slowly. Toxitabellae Hydrargyri Bichloridi Magnse, Large Poison Tablets of Mercury Bichloride, U. S. P.—Each tablet contains an average of not less than 0.45 Gm. and not more than 0.55 Gm. of HgCh, with a sufficient quantity of a suitable excipient or diluent. Average dose: 0.06 Gm. or 1 grain. These tablets must be of a distinctive color, not white; they must be of an angular or irregular shape, not discoid. When sold in small quantities suitable 212 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY for household use, they must be dispensed in glass containers of a distinctive, angular shape having irregular or roughened sides or edges. On the exterior of each container must be placed a red printed label bearing the word “POISON”, and a statement indicating the amount of mercury bichloride in each tablet. Uses : These tablets are used for convenient preparation of bicholoride solu- tion. One tablet dissolved in 500 cc of water makes a 1 in 1,000 solution. Toxitabellse Hydrargyri Bichloridi Parvae, Small Poison Tablets of Mercury Bichloride, U. S. P.—Each tablet contains an average of not less than, 0.1125 Gm, and not more than 0.1375 Gm. of HgCh, with a sufficient quantity of a suitable excipient or diluent. These tablets must be of a distinctive color, not white; they must be of an angular or irregular shape, not discoid. When sold in small quantities suitable for household use, they must be dispensed in glass containers of a distinctive angular shape having irregular or roughened sides or edges. On the exterior of each container must be placed a red printed label bearing the word “POISON”, and a statement indicating the amount of mercury bichloride in each tablet. Uses : These tablets are used for convenient preparation of small quantities of bichloride solution. One tablet dissolved in 500 cc of water makes a 1 in 4,000 solution. Unguentum Hydrargyri Forte, Strong Mercurial Ointment, U. S. P.—It con- tains not less than 49 per cent and not more than 51 per cent of Hg. The globules of mercury should be so fine that they are not visible under a lens magnifying 10 diameters. The base is composed of oleate of mercury, white wax, wool fat, and petrolatum. It is used in the preparation of Mild Mer- curial Ointment. Action and Uses: It is rubbed into the skin in the treatment of syphilis. Four grams of the ointment should be rubbed into a selected area of the skin at night and the part should be cleaned in the morning. A new area should be selected for inunction the following night to avoid irritation of the skin. If the ointment is irritating it should be diluted with wool fat. Unguentum Hydrargyri Mite, Mild Mercurial Ointment (Blue Ointment), U. S. P.—It contains not less than 29 per cent and not more than 31 per cent of Hg. In each 100 Gm. there are 60 Gm. of Strong Mercurial Ointment, 2 Gm. of white wax, and 38 Gm. of white petrolatum. Action and Uses: It is a paraciticide and is rubbed on the skin to destroy lice. Hydrargyri Oxycyanidum, Mercuric Oxycyanide, Hg(CN)2 HgO, N. N. R.—It is a basic mercuric salt of hydrocyanic acid containing from 51.7 to 56 per cent of mercuric cyanide (Hg(CN)2) and from 44.3 to 48.0 per cent of mercuric oxide (HgO). Protect it from light in well-closed bottles. Properties : It is a white or nearly white, microcrystalline powder. One part is soluble in 80 parts of water yielding a solution which is alkaline to litmus paper. Action and Uses: It is an antiseptic which does not precipitate albumin, and in dilute solution does not attack surgical instruments. It is used in the dis- infection of surgical instruments that cannot be boiled. It is used in genito- urinary work for the disinfection of cystoscopes, 1 part of mercuric oxycyanide to 1,000 parts of water. Mercurochrome, Mercurochrome soluble, N. N. R.—It is the disodium salt of dibromohydroxymercurifluorescein containing 24 to 26 per cent of mercury. MATERIA MEDICA AND THERAPEUTICS 213 Properties : It occurs as iridescent, green scales or granules, odorless, and permanent in the air. It is freely soluble in water and practically insoluble in alcohol. The aqueous solution is stable in the air, does not precipitate pro- teins and does not respond to the usual tests for mercury ions. Action and uses : It is nonirritating, moderately active, antiseptic. It stains the skin red. The stains can be removed by washing with sodium hypochlorite solution or 3 per cent hydrochloric acid in alcohol. Mercurochrome Solution (Scott’s Solution) for disinfection of the skin before operation is composed of 2 parts mercurochrome, 35 parts distilled water, 55 parts alcohol, and 10 parts acetone. Merthiolate, Merthiolate Sodium, Sodium Ethylmercuri Thiosalicylate, N. N. R.— Merthiolate contains about 49 per cent of mercury in organic combination. Properties : It is a light, cream colored, crystalline powder, having a slight odor. It is stable in air but unstable in sunlight. One part is soluble in 1 part of water, or in 8 parts of alcohol. Action and Uses : It has high germicidal potency against spore-bearing and non-spore-bearing bacteria and is also’ a fungicide. It does not precipitate with serum proteins and does not irritate. For disinfection of the skin use 1 in 1,000 alcoholic solution; for wounds use 1 in 1,000 water solution; for instru- ments use 1 in 1,000 water solution. Silver compounds. Argenti Ultras, Silver Nitrate, AgNo3, U. S. P.—It contains, when powdered and dried to constant weight in a desiccator over sulfuric acid, in the dark, not less than 99.8 per cent of AgNOa. Preserve it in dark amber-colored, glass- stoppered vials, protected from light. Properties : Occurs in colorless, transparent, tabular, rhombic crystals, be- coming gray or grayish black on exposure to light or in the presence of organic matter; odorless, and having a bitter, caustic, and strongly metallic taste. Soluble in 0.4 part of water and in 30 parts of alcohol. An aqueous solution is clear, colorless, and neutral to litmus paper. Preparation : It is made by dissolving silver in nitric acid with the aid of heat, 3Ag+4HN03=3AgN03+2H20+N0. Action and Uses: Solutions of silver nitrate should be made with distilled water. Weak solutions are astringent and antiseptic to mucous membranes and strong solutions are caustic. The mucous membrane should always be cleaned before applying solutions of silver nitrate. A 1 per cent solution is instilled into the eyes of the newborn immediately after delivery to prevent gonorrhoeal conjunctivitis. The action of silver nitrate can be immediately stopped by the application of sodium chloride (salt) solution and this is often done when it is desired to limit the action of local application to the eye or throat. Silver nitrate forms on tissue a dense film of coagulated albumin. This film prevents deeper action of the silver nitrate. The film is at first white but soon becomes black due to the reduction of the silver. A 4 per cent solution is used for application to the mucous membrane of the throat, mouth or nose. Argenti Nitras Induratus, Toughened Silver Nitrate (lunar Caustic), U. S. P.— Toughened Silver Nitrate contains not less than 94.5 per cent of AgNOs. Pre- serve it in glass-stoppered bottles, in a cool place and protected from light. Average dose: 0.01 Gm. or % grain. Description : White, crystalline masses generally molded as pencils or cones. It breaks with a fibrous fracture. On exposure to light in the presence of organic matter Toughened Silver Nitrate becomes gray or grayish-black. It contains about 5 per cent silver chloride. 214 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Action and Uses : It is used as a caustic on excessive granulations, chanc- roids, and ulcers. The mode of application consists of dipping the stick into distilled water and applying to the part according to the degree of action desired. Argentum Proteinicum Forte, Strong Protein Silver (Strong Silver Protein), U. S. P.—A compound of silver and protein, containing not less than 7.5 per cent and not more than 8.5 per cent of Ag. Preserve it in well-closed containers and protected from light. CAUTION: Solutions of Strong Protein Silver should he freshly prepared with distilled water and should he dispensed in amher-colored bottles. Description : A brown, odorless powder, usually somewhat hygroscopic. It is freely soluble in water, but almost insoluble in alcohol. Sodium chloride does not precipitate silver from a solution of silver protein. With mercuric chloride test solution a white precipitate is formed and the supernatant liquid becomes colorless or nearly so. Action and Uses: It is used in one-half of 1 per cent aqueous solution for injection into the urethra for the prevention and treatment of gonococcus infection of the urethra. The solution should be made in small quantities as needed. It is more irritating than Mild Silver Protein. Linen stains may be removed with 1-1,000 bichloride of mercury solution. Argentum Proteinicum Mite, Mild Protein Silver (Mild Silver Protein), U. S. P.—Silver rendered colloidal by the presence of, or combination with, protein. It contains not less than 19 per cent and not more than 25 per cent of Ag. CAUTION: Solutions of Mild Protein Silver should he freshly prepared with distilled water and should he dispensed in amher-colored hottles. Preserve it in well-closed containers and protected from light. Description : Dark brown or almost black shining scales or granules. It is odorless, and is frequently hygroscopic. It is freely soluble in water, but almost insoluble in alcohol. With sodium chloride solution, a solution of silver protein does not precipitate silver. With mercuric chloride test solution a white precipitate is formed and the supernatant liquid becomes colorless, or nearly so. Penis syringes should not be kept in a bichloride of mercury solution if they are to be used with either the strong or the mild silver protein. Action and Uses: In the preparation of solutions of silver protein they are likely to gum together if water is poured upon them; they then dissolve very slowly, but solutions can be made quickly if they are sprinkled upon the water and immediately shaken for a minute or two. Solution is also aided by wetting them first with glycerin. It is nonirritating and soothing, but less active as an antiseptic than Strong Protein Silver. It is used in the treatment of inflamed sensitive mucous membranes of the urethra, eye, and throat. It is usually used in strengths of from 5 to 20 per cent in distilled water. Copper compounds. Cupri Sulfas, Copper Sulfate, (Blue Vitriol, Bluestone, Cupric Sulfate), Cu'S04.5H20, U. S. P.—It contains not less than 63 per cent nor more than 66.8 per cent of CuSCL, corresponding to not less than 98.5 per cent of the hydrated salt (CUSO4+5H20). Preserve it in well-closed containers. Properties: It occurs as deep blue triclinic crystals, or as blue crystalline granules or power, having a nauseous, metallic taste; slowly efflorescent in dry air; soluble in 3 parts of water, 500 parts of alcohol, and 2.8 parts of glycerin. Its aqueous solution is acid to litmus. Preparation: It is made by the action of sulfuric acid on copper. Cu+ 2HaS04=CuS04+S02+2H20. MATERIA MEDICA AND THERAPEUTICS 215 Action and Uses: Internally it is used as an emetic, an astringent, or tonic, and an antidote for phosphorus poisoning. In small doses it acts as an as- tringent, while in large doses it is an irritant and is nauseating. It is astrin- gent and antiseptic even in a strength of 1 to 1,000. Its aqueous solution is very destructive to the lower forms of plant life (fungi). It is used in the preparation of Fehling’s solution, a reagent used in testing for the presence of sugar in urine. Average dose: 0.3 Gm. or 5 grains as an emetic; 0.01 to 0.03 Gm. or % to Y2 grain as an astringent or tonic. ORGANIC MATERIA MEDICA In the study of inorganic materia medica it was found that most of the substances were obtained or derived from the mineral kingdom. In the study of organic materia medica it will be found that most of the substances are obtained or derived from the vegetable and animal kingdoms or are made synthetically. Organic materia medica is the study of those compounds of carhon that are used in medicine. In this chapter only those used in the Medical Department of the Navy are discussed. The substances have been divided into groups, as far as practicable, according to chemical classification. Hydrocarbons. Hydrocarbons are chemical compounds formed by the union of the elements hydrogen and carbon. There are hundreds of these compounds, but only a few are on the Supply Table. For the general properties of the hydrocarbons refer to the chapter on Chemistry. Petrolatum, Petrolatum (Petroleum Jelly), U. S. P.—A purified mixture of semisolid hydrocarbons, obtained from petroleum. Properties : It is an unctuous mass; yellowish to light amber in color; trans- parent in thin layers; free from odor and taste. It is insoluble in water, almost insoluble in alcohol, soluble in ether, chloroform, oil of turpentine, benzine, or in most fixed or volatile oils. It melts between 38° and 54° C. Chemically it is very stable and does not turn rancid like vegetable oils and animal fats. It remains unchanged when brought in contact with strong acids or alkalies. Preparation ; It is an intermediate product in the distillation of crude petroleum. It comprises a part of the residue left after distillation of the lighter substances. Action and Uses ; It is used as a bland, neutral, protective dressing, and as a base for ointments. The absorption and rapidity of action of drugs is re- tarded when incorporated with petrolatum; therefore it should not be used alone as an ointment base when absorption of a drug is desired. Given in- ternally it is not absorbed from the intestinal tract; it acts as a lubricant and may be used in gastrointestinal irritation. White Petrolatum, U. S. P., is petrolatum that has been decolorized. Petrolatum Liquidum, Liquid Petrolatum (Mineral Oil, Liquid Paraffin), U. S. P.—A mixture of liquid hydrocarbons obtained from petroleum. Preserve it in well-closed containers, protected from light. The U. S. P. recognizes two kinds of liquid petrolatum—heavy liquid petrolatum having a viscosity of not more than 0.381, which is intended to be used as a laxative, and light liquid petrolatum having a viscosity of not more than 0.370 and intended to be used as a solvent in making sprays. Properties; Both varieties are colorless, transparent, oily liquids; free or nearly free from fluorescence, odorless and tasteless when cold; insoluble in water or alcohol, but soluble in ether, chloroform, benzine, and volatile oils. 216 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY It is miscible with most fixed oils and dissolves menthol, camphor, and similar substances. Preparation" : It is made from crude petroleum after removal of the lighter hydrocarbons (gasoline, kerosene,, etc.) by distilling the residue between 330° and 390° O. It should be noted that the definition does not state that it is a mixture of hydrocarbons of any particular chemical series. Action and Uses : Largely used in the treatment of constipation. Its action is mechanical, as it is not absorbed. It simply oils the entire intestinal tract and facilitates the passage of the fsecal mass. Used as a vehicle in the prepa- ration of the oil sprays for the nose and throat and in the preparation of petroxolins (N. F. preparations). Average dose: 15 cc or 4 fluidrams. Paraffinum, Paraffin, U. S. P.—A purified mixture of solid hydrocarbons obtained from petroleum. Properties : It is a colorless or white, more or less translucent mass, crystal- line when separating from solution, without odor or taste, and slightly greasy to the touch. It is insoluble in water or alcohol, but freely soluble in ether, benzene, volatile oils, and most fixed oils when warm. Like petrolatum, it is chemically inactive and resistant to the action of other chemicals. It melts between 50° and 57° G. Preparation : It is made by distilling the residuum obtained from the refining of crude petroleum and collecting and purifying the distillate. Action and Uses: It is used in ointments in hot climates to raise their melt- ing points; in making paraffin paper; for sealing bottles; in making candles; and in the preparation of paraffin-wax compounds. Paraffin Dressing, N. F., is used as a surgical dressing for burns. Ichthammol (Ammonium Ichthosulfonate), N. F.—It is obtained by the destructive distillation of certain bituminous schists, sulfonating the distillate, and neutralizing the product with ammonia. Ichthammol yields not less than 2.5 per cent of ammonia, not more than 8 per cent of ammonium sulfate, and not less than 10 per cent of total sulfur. Properties: It is a reddish-brown to brownish-black, viscous fluid with a strong, characteristic, empyreumatic odor. It is soluble in water and in glycerin, and is miscible with fixed oils and fats. It is partly soluble in alcohol or ether, and entirely soluble in a mixture of equal volumes of alcohol and ether. Action and Uses : It is weakly antiseptic and emollient. It is used in oint- ments (Ointment of Ichthammol, N. F.) for the local treatment of furunculosis (boils). It is not given internally. Halogen derivatives of hydrocarbons. Halogen derivatives of hydrocarbons are compounds formed by substituting one or more halogen atoms (chlorine, bromine, fluorine, or iodine) for a cor- responding number of hydrogen atoms in hydrocarbon compounds. The sub- stitution may be done directly or indirectly. {See chapter on Chemistry.) The simplest hydrocarbon known is methane, CH4, which contains four hydrogen atoms united to one carbon atom. Substituting three chlorine atoms for three of the hydrogen atoms in methane produces a compound known as trichlor- methane, CHCL (chloroform) ; if the substitution is with three iodine atoms, a compound known as triiodomethane, CHL (iodoform) results; if one chlorine atom is substituted for one hydrogen atom in ethane (OsHs), a compound known as monochlorethane, C2H5CI (ethyl chloride), is formed, etc. Chloroformum, Chloroform, CHCL, U. S. P.—A liquid consisting of not less than 99 per cent nor more than 99.5 per cent by weight of OHCU and the 217 MATERIA MEDICA AND THERAPEUTICS remainder consisting of alcohol. Preserve it in well-stoppered bottles in a cool place protected from light. Caution : Care should he used in vaporizing chloro- form in the presence of a naked flame, as noxious gases are produced. Chloro- form for anaesthesia must he preserved in glass bottles. Properties; A clear, colorless, mobile liquid, of a characteristic, ethereal odor and burning, sweet taste. Soluble in 210 parts of water; miscible with alcohol, ether, benzene, petroleum, benzine, or with fixed or volatile oils. Specific grav- ity, 1.474 to 1.478 at 25° C. It is volatile at a low temperature and boils at about 81° C. It is not inflammable, but its heated vapor burns with a green flame. Chloroform is decomposed when exposed to light and air, liberating chlorine, hydrochloric acid, phosgene, and other compounds. The presence of a small amount of alcohol tends to prevent this decomposition. Chloroform that has been exposed to light and air should not be used for anaesthesia. Preparation : It is usually made by the action of chlorinated lime on acetone. Action and Uses: Used in surgery as a general anaesthetic by inhalation; internally as a carminative and sedative; externally as a rubefacient and vesicant. It is used in the preparation of Chloroform Water, U. S. P., Chloro- form Liniment, U. S. P., and Spirit of Chloroform, U. S. P. lodoformum, Iodoform, CHI3, U. S. P.—Triiodomethane. Preserve it in well- closed containers, in a cool place and protected from light. Average dose: 0.3 cc or 5 minims. Properties: It occurs as a fine, lemon-yellow powder or in lustrous crystals of the hexagonal system having a peculiar, very penetrating and persistent odor and an unpleasant, slightly sweetish taste suggestive of iodine. It is nearly insoluble in water, but soluble in 60 parts of alcohol, 80 parts of glycerin, 10 parts of chloroform, 7.5 parts of ether, 2.8 parts of carbon disulfide and in 34 parts of olive oil. The unpleasant odor may be partially disguised in ointments by adding 5 drops of oil of peppermint to the ounce. The odor of iodoform on utensils may be partially removed by wiping them off with oil of turpentine, followed by washing with soap and water. Preparation : Made by the action of iodine upon alcohol or acetone in the presence of an alkali or alkali carbonate. Action and Uses: It is used externally in the form of dusting powder, oint- ment, or iodoform gauze as an antiseptic and stimulating dressing to wounds and ulcers. Its antiseptic properties are due to iodine, of which it contains over 96 per cent by weight. Iodoform gauze may be made by saturating surgi- cal gauze with a 5 per cent solution of iodoform in ether and allowing to dry. Average dose: 0.25 Gm. or 4 grains. (Rarely given internally.) ASthylis Chloridum, Ethyl Chloride, CH3CH2CI, U. S. P.—Monochlorethane. Preserve it in hermetically sealed containers in a cool place, remote from fire and protected from light. Properties : At low temperatures or under pressure ethyl chloride is a color- less, mobile, very volatile liquid, having a characteristic ethereal odor and a burn- ing taste. It boils between 12° and 13° C. It burns with a smoky, greenish flame with the production of hydrochloric acid. When liberated at room tem- perature from its sealed container it vaporizes at once. Caution: The gas is very inflammable and must not be used in proximity to fire. Preparation : Ethyl chloride may be made by the action of hydrochloric acid upon alcohol: C2H50H+HC1=C-.H5C1+H20. Action and Uses: When inhaled it produces general anaesthesia promptly and may be used for operations that require only a few minutes. Sprayed on a part of the body it produces refrigeration and is used as a local anaesthetic in minor operations. 218 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Carbonei Tetrachloridum, Carbon Tetrachloride, (Tetrachlormethane), CC14, U. S. P. Properties : A clear, colorless, mobile liquid. It has a characteristic, ethereal odor, resembling that of chloroform. It is not inflammable. It is slowly de- composed by light, and by various metals if moisture is present. It is almost insoluble in water. It is miscible with alcohol, chloroform, ether, benzene, petroleum benzine, and dissolves most of the fixed and volatile oils. It has a high specific gravity and a low boiling point. It should be preserved in well- closed containers and protected from light. Preparation : It is made by the action of chlorine upon carbon disulfide under the influence of a catalytic agent. Action and Uses : It has narcotic and anaesthetic properties somewhat similar to those of chloroform. It is given internally as a vermifuge in the treatment of hookworm disease, and also removes some other intestinal 'worms. Its ad- ministration should be followed in 3. hours by a purgative dose of magnesium sulfate. It is used as a fire extinguisher (pyrene). When used as a fire extin- guisher, poisonous gases—phosgene and hydrochloric acid—are formed by the heat, and unless these gases are blown away from the man using the fire extin- guisher poisoning is likely to occur. It should not be used in unventilated spaces or closed compartments. Average dose: 2.5 cc or 40 minims. (This is a single dose for an adult as an anthelmintic and is not to be repeated under 3 weeks.) Chloramina-T, Chloramine-T, U. S. P.—Sodium paratoluenesulfonchloramide containing the equivalent of not less than 11.5 per cent and not more than 13 per cent of active chlorine (01). Preserve it in well-closed containers protected from light. Properties: A white or faintly yellow, crystalline powder, having a slight odor of chlorine. It slowly decomposes on exposure to air, losing chlorine. One gram is soluble in 7 cc of water. It is soluble in alcohol but the solution decomposes on standing. Action and Uses : It is used in 0.1 to 4 per cent aqueous solution as an anti- septic wound dressing. It was first used during the World War as a substitute for Dakin’s Solution (Solution of Sodium Hypochlorite). It has the advan- tage over Dakin’s Solution of greater stability, is easier to prepare, and pro- duces less irritation. It lacks the solvent action of the alkaline hypochlorites. Alcohols. Alcohols are compounds formed by the replacement of one of more hydrogen atoms of a paraffin hydrocarbon with an equal number of hydroxyl (OH) groups. If one hydroxyl group is substituted for one hydrogen atom in methane (CH4) an alcohol known as methanol (CHsOH) (methyl or wood alco- hol) results; if one hydroxyl group is substituted for one hydrogen atom in ethane (GHa) an alcohol known as ethanol (GH5OH) (ethyl or grain alcohol) is obtained; if three hydroxyl groups are substituted for three hydrogen atoms in propane (GHS) an alcohol known as glycerol (GH5(OH)s) (glyceric alcohol or glycerin) occurs. Alcohols are designated monatomic, diatomic, triatomic, etc., accordingly as they contain one, two, three, etc., hydroxyl (OH) groups. Alcohols are related closely to hydroxides or bases in inorganic chemistry, and sometimes they are referred to as organic hydroxides. When acted upon by an acid they form a salt (ester) and water which is analogous to the reaction that takes place when an acid acts on a base (hydroxide). They have a neutral reaction to litmus if pure. Alcohol, Alcohol (Ethanol, Ethyl Alcohol), C2H50H, U. S. P.—A mixture of alcohol and water containing not less than 92.3 per cent by weight or 94.9 per MATERIA MEDICA AND THERAPEUTICS 219 cent by volume at 15.56° C., of C2H5OH. Preserve it in well-closed containers in a cool place, remote from fire. Properties : It is a transparent, colorless, mobile, and volatile liquid, having a slight characteristic odor and a burning taste. Miscible in all proportions with water, ether, and chloroform. Specific gravity not above 0.816 at 15.56° G. (the United States Government standard temperature for alcohol). It is easily volatilized at low temperature and boils at 78° C. It is inflammable and burns with a pale blue, smokeless flame. Preparation: Alcohol is made by the fermentation of starch contained in grain. In making U. S. P. alcohol, rectified spirit is macerated with dehydrat- ing agents (quicklime) .to remove water, and then is.distilled. Action and Uses: Alcohol is used as a diffusible stimulant and hypnotic. Large doses cause intoxication by depression and, finally, paralysis of the cen- tral nervous system. Externally alcohol is used as a refrigerant in giving baths and alcohol rubs. It is a valuable bacteriostatic and is used extensively in surgery in 70 per cent strength. In pharmacy it is used as a solvent in making spirits, tinctures, elixirs, and fluid extracts. Average dose: 10 ce or 2.5 fluidrams. Alcohol Dilution, Diluted Alcohol, U. S. P.—A liquid containing from 41 to 42 per cent by weight, or from 48.4 to 49.5 per cent by volume at 15.56° C. of C2H5OH. Preserve it in well-closed containers, in a cool place, remote from fire. Preparation ; It is made by mixing equal volumes of U. S. P. alcohol and distilled water. When 500 ce of alcohol and 500 cc of distilled water are mixed, instead of getting 1,000 cc of dilute alcohol only about 970 cc are obtained due to contraction in volume when these two liquids are mixed. Alcohol Dehydratum, Dehydrated Alcohol, U. S. P.—A liquid commonly known as absolute alcohol and containing not less than 99 per cent by weight of C2H5OH. Preserve it in well-closed containers, in a cool place, remote from fire. If the stopper is removed, it should be securely replaced as soon as possible to prevent the absorption of water from the air. Preparation ; It is made from ordinary alcohol by redistillation after per- colation through lime. There is still remaining 1 per cent of water, which is allowed. Alcohol Methylic, Methyl Alcohol (Wood Alcohol, Wood Naphtha, Wood Spirit, Carbinol, Methanol), CH30H.—Methyl alcohol is made by the destructive distil- lation of wood. Action and Uses : Absolute alcohol is used in microscopical work. Action and Uses : It is used in microscopical work. It is an excellent solvent, but is unfit for use in pharmacy because it is a dangerous poison, pro- ducing blindness and death. It is used in denaturing ethyl alcohol and in making formaldehyde. Caution : It should never he used internally. Spiritus Frumenti, Whisky, U. S. P.—An alcoholic liquid obtained by the distillation of the fermented mash of wholly or partly malted cereal grains, and containing, at 15.56° C., not less than 47 per cent and not more than 53 per cent, by volume, of CJUOH. It must have been stored in charred wood containers for a period of not less than 4 years. Properties : A light to deep amber-colored liquid, having a characteristic odor and taste, and an acid reaction. Action and Uses : It is given Internally as a diffusible stimulant. Diluted Alcohol may be used internally in the place of Whisky. Glycerinum, Glycerin, (Glycerol), C3Hr,(0H)3, U. S. P.—A liquid obtained by the hydrolysis of vegetable or animal fats, or fixed oils; purified by distillation. 154294°—89—15 220 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY and containing not less than 95 per cent of the trihydric alcohol C3Hs(OH)3 or CH2OH.CHOH.CH2OH. Preserve it in well-closed containers. Properties : It is a clear, colorless liquid, of a thick, syrupy consistency, having not more than a slight characteristic odor; sweet to the taste and producing a sense of warmth in the mouth; when it is exposed to the air it absorbs moisture. It is miscible with water or alcohol in all proportions; insoluble in chloroform, ether, benzene, petroleum benzine, and fixed or volatile oils. Preparation ; Glycerin is a by-product in the manufacture of soap. When- ever an alkali acts on a fixed oil or an animal fat a soap and glycerin are formed. The process is called saponification. Action and Uses: It is extensively used in pharmacy as a solvent. It pos- sesses the advantages of easily mixing with alcohol and water; is slightly antiseptic and preservative; has a sweet taste, and will dissolve many me- dicinal substances. It is used in making glycerin suppositories, glycerinated gelatin, and glycerites. It tends to keep substances from becoming hard. Aldehydes and aldehyde derivatives. The word “aldehyde” is derived from alcohol dehydrogenatum, meaning alcohol from which hydrogen has been extracted, and referring to the method of preparing aldehydes. If two atoms of hydrogen are extracted from methyl alcohol (CHs.OH—H2=H.CHO), formic aldehyde or formaldehyde is formed. The extraction of the hydrogen usually is accomplished by bringing some substance in contact with the alcohol that has a greater attraction for the hydrogen than has the carbon. Such a substance is oxygen, and the process of extracting the hydrogen is called oxidation; therefore it is said that for- maldehyde is made by the oxidation of methyl alcohol. When an aldehyde is oxidized (th,is time the oxygen is added to the carbon instead of taking something from it), it is converted into an acid: (2H.CHO+02=::2H.COOH) ; when acetic aldehyde is oxidized it is converted into acetic acid: (2CH3.CHO + 02=2CH3C00H). The aldehyde group is CHO and is contained in all aldehydes. , Liquor Formaldehydi, Solution of Formaldehyde (Formalin), H.CHO, U. S. P.— An aqueous solution containing not less than 37 per cent by weight of H.CHO with varying amounts of methanol to prevent polymerization. Preserve it in a moderately warm place, protected from light. Properties: It is a clear, colorless, or nearly colorless liquid having a pungent odor and a caustic taste; its vapor acts as an irritant upon mucous mem- branes. It is miscible with water or alcohol. On long standing, especially in the cold, Solution of Formaldehyde sometimes loses its transparency, the cloudiness being due to the separation of paraformaldehyde (polymerization). Chemically it is a reducing agent. Preparation: It is made by the oxidation of methyl alcohol: 2CH3.0H+02= 2H.CH0+2H20. Action and Uses : It is a powerful antiseptic and disinfectant. It acts as a disinfectant in aqueous solution in strengths of from 1 to 2 per cent (per cent here refers to the amount of absolute formaldehyde, H.CHO). This strength may be used in the disinfection of the hands, linen, or surgical instruments having cutting edges. A 1 to 10 solution in alcohol is used for the preser- vation of tissue. A solution composed of 13.5 cc of formalin, 5 Gm. of borax, and sufficient water to make 100 cc is used as an embalming fluid. It is used as a room disinfectant with barium dioxide. Five hundred cc of formalin mixed with 250 Gm. of barium dioxide in a suitable container will generate sufficient 221 MATERIA MEDICA AND THERAPEUTICS formaldehyde gas to disinfect 1,000 cubic feet of air space. Formaldehyde is one of the few true deodorants. Methenamina, Methenamine (Hexamethylenetetramine). U. S. P.—A con- densation product of ammonia and formaldehyde containing not less than 99 per cent of (CH2)aN4. Preserve it in well-closed containers. Pkopektibs : It occurs as colorless, lustrous, odorless crystals, or a white, crystalline powder; soluble in 1.5 parts of water and in 12.5 parts of alcohol. Its aqueous solution is alkaline to litmus. Preparation : It is made by the action of ammonia on formaldehyde. Action and Uses: It is a urinary antiseptic, its antiseptic action being due to the liberation of formaldehyde in the normally acid urine in the bladder. Unless the urine in the bladder is acid there will not be enough formaldehyde set free to do any good and it is therefore often given in conjunction with acid sodium phosphate which renders the urine acid and permits more formaldehyde to be liberated. It has produced hsematuria and should be used cautiously. Average dose: 0.25 Gm. or 4 grains. Chloralis Hydras, Chloral Hydrate (Chloral), U. S. P.—A compound of trichloracetaldehyde or chloral, with the elements of one molecule of water. It contains not less than 99.5 per cent of C2H3O2CI3. Preserve it in tightly stoppered bottles, in a cool place, protected from light. Properties : It occurs in colorless, transparent crystals having an aromatic, penetrating, and slightly acrid odor, and a bitterish, caustic "taste. It is slowly volatilized when exposed to the air. It is soluble in 0.25 part of water, 1.3* parts of alcohol, 2 parts of chloroform, and 1.5 parts of ether; very soluble in olive oil, freely soluble in oil of turpentine. It is decomposed by alkalies, liberating chloroform. Preparation : It is made by passing chlorine gas through absolute alcohol, resulting first in the conversion of alcohol to acetaldehyde, and then the acetal- dehyde is converted into trichloracetaldehyde (chloral). (1) CH3CH2OH+Cl2=CH3CHO+2HCI (2) CH3CHO+SCI2 = CClaCHO -f BHC1 Action and Uses : It is a powerful nerve sedative and hypnotic and is used in insomnia, hysteria, the various forms of insanity, and delirium tremens. It usually is given with bromides. It is used to cause muscular relaxation in tetanus and strychnine poisoning, when large doses are necessary. It is a habit-forming drug and should be used cautiously. It is one of the 11 drugs mentioned in the Federal Pure Food and Drugs Act and the amount contained in any preparation must appear on the label when it enters interstate commerce. Average dose: 0.5 Gm. or 8 grains. Ethers. Ethers may be defined as oxides of hydrocarbon radicals. There are simple ethers and mixed ethers. Simple ethers are formed by the union of two like hydrocarbon radicals with one oxgen atom; (C2H5)20 is diethyl ether (ether) ; compound ethers are formed by the union of two unlike hydrocarbon radicals with one oxygen atom, (CH3)(02H5)0 is methyl-ethyl ether. Ethers in organic chemistry are analogous to oxides in inorganic chemistry. The term very often is applied erroneously to esters. It should be understood clearly that ethers and esters are two different and distinct classes of organic compounds. Ethers are organic oxides, while esters are organic salts. (See chapter on Chemistry.) .ffither, Ether (Sulfuric Ether), (C2H5)20, U. S. P.—A liquid containing not less than 96 per cent nor more than 98 per cent of ethyl oxide ( the re- 222 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY mainder consisting of alcohol and water. Preserve it in partially filled, well- closed, light-proof containers, in a cool place, remote from fire. When ether is to be used for anaesthesia it is to be dispensed only in small, well-closed con- tainers and is not to be used for this purpose if the container has been opened longer than 24 hours. Properties : Ether is a transparent, colorless, mobile liquid, having a char- acteristic odor and a burning sweetish taste. It is soluble in 12 parts of water and is miscible with alcohol, chloroform, petroleum benzine, benzene, or fixed and volatile oils. It boils at about 35° C. It is highly volatile and inflam- mable. Its vapor when mixed with air and ignited may explode violently. It is slowly oxidized by the action of air, moisture, and daylight. Preparation :It is made by the action of sulfuric acid on alcohol. (1) C2H50H+H2S04=C2H5HS04+H20 (2) GJ1-M S O.+C2H5OH= (C2H3)20+H2S04 Action and Uses : It is administered by inhalation to produce general anaesthesia. In the administration of ether great care should be exercised to see that a flame is not brought near the vapor. In pharmacy it is used as a solvent in the preparation of oleoresins and in the assay of alkaloids. Given internally it acts as a cardiac stimulant, carminative, and antispasmodic. Sol- vent Ether was admitted to the Eleventh Revision of the U. S. P. under the name “Ethyl Oxide”, and may be purchased in larger containers at a lower cost than ‘‘Anaesthetic Ether.” The tests for aldehydes and peroxides in Ethyl Oxide are less rigid than for ASther, U. S. P. Phenols and phenol derivatives. Phenols may be defined as compounds formed by the substitution of one or more hydroxyl (OH) groups for a corresponding number of hydrogen atoms that are connected directly with carbon atoms in the benzene nucleus (C6H8). A phenol formed by substituting one hydroxyl (OH) group for one hydrogen atom in benzene (C8H8) is known as a monatomic phenol (CJELOH), ordinary phenol; the substitution of two hydroxyls for two hydrogens would give a diatomic phenol (C8H4(OH)2), resorcinol; the substitution of three hydroxyls for three hydrogens would give a triatomic phenol (C8H3(OH)3), pyrogallol. The substitution of three nitro groups for three of the hydrogen atoms in phenol (GiHsOH) gives a compound known as trinitro-phenol (G8H.0H(N02)3, or picric acid. It should be understood clearly that phenols are a distinct class of compounds. The term “phenol” is the name given to the most impor- tant member in this class, just as “alcohol” is the name applied to the most important member in the class of alcohols and the term “ether” to the most important member of the class of ethers. Some of the phenols are liquids and some are solids; they all have a characteristic odor; they act like weak acids, forming salts with strong alkalies, but they do not decompose carbonates, and their reaction to litmus is neutral or only faintly acid. They are nearly all very poisonous; most of them are disinfectants or antiseptics; are soluble in alcohol and sparingly soluble in water. Some are found in the vegetable kingdom (thymol) and some are formed when complex carbon compounds are subjected to destructive distillation; wood tar and coal tar, the residues resulting from the destructive distillation of wood and coal, contain phenols (phenol and cresol). A general measure against the caustic action of phenols (externally) is ethyl alcohol (grain alcohol), which dilutes the phenol, thereby weakening its action as well as making it easier to remove. Wash off - the phenol thoroughly wnth alcohol and. then apply cotton-seed oil dressings. Oils prevent penetration of 223 MATERIA MEDICA AND THERAPEUTICS phenol into the tissues and absorb phenol from the tissues. For the treatment of poisoning by phenol when it has been swallowed see section on Toxicology. Phenol, Phenol (Carbolic Acid), CsHsOH, U. S. P.—It is obtained from coal tar or made synthetically. It contains not less than 98 per cent of C«H5OH. Preserve it in well-closed containers, protected from light. Properties : It occurs as colorless, interlaced or separate needle-shaped crystals, or as a white, crystalline mass, sometimes acquiring a red tint, hav- ing a characteristic, somewhat aromatic odor. When undiluted it cauterizes and whitens the skin and mucous membrane. It is soluble in 15 parts of water; very soluble in alcohol, glycerin, chloroform, ether, and in fixed or volatile oils. When heated it melts, forming a highly refractive liquid. It also is liquefied by the addition of about 8 per cent of water. Preparation ; It is obtained from coal tar by fractional distillation and subsequent purification. It also is made synthetically. Phenol Liquefaction, Liquefied Phenol (Liquefied Carbolic Acid), U. S. P.—A liquid containing not less than 88 per cent of CgILOH and about 10 per cent of water. Preserve it in well-closed containers, protected from the light. Action and Uses. See Liquefied Phenol. Properties : It is a colorless liquid, which may develop a red tint upon keeping, having a characteristic, somewhat aromatic odor. When undiluted it cauterizes the skin and mucous membrane. It is miscible with ether, alcohol, and glycerin. When it is diluted with an equal volume of glycerin the mixture is miscible with water. Preparation: It is made by melting crystallized phenol on a water bath. It then is poured into a tared vessel and weighed, and to every 9 Gm. of phenol is added 1 Gm. (1 cc) of distilled water, mixed thoroughly. Action and Uses: It is a valuable antiseptic and disinfectant. A 5 per cent solution may be used for the disinfection of the hands, soiled linen, stools, urine, bedpans, urinals, etc. In concentrated form it acts as a caustic and local anaesthetic. Applied in a tooth cavity on a small pellet of cotton that has first been touched to another piece of cotton to remove excess fluid, it relieves toothache. If pure phenol is spilled on the skin or in the mouth, it should be washed off immediately with alcohol. The concentrated phenol coagulates albumin, but its weaker aqueous solutions do not. Concentrated liquefied phenol is used for the disinfection of cutting-edged instruments which are damaged by boiling; after taking the instruments out of the phenol they are rinsed in alcohol to remove all the phenol. When phenol is to be mixed with a fixed oil, liquid petrolatum, or petrolatum, use melted crystalline phenol in- stead of liquefied phenol, because the water in liquefied phenol is insoluble in these solvents. Average dose: 0.05 cc or 1 minim. Cresol, Cresol (Tricresol), U. S. P.—A mixture of isomeric cresols, CeH4.CH3.OH, obtained from coal tar. Preserve it in well-closed containers, protected from light. Properties: It occurs as a colorless or yellowish to brownish-yellow, highly refractive liquid, becoming darker or assuming a reddish tint with age and on exposure to light, and having a phenol-like, sometimes empyreumatic odor. It is soluble in 50 parts of water; miscible with alcohol, ether, glycerin, ben- zene, or petroleum benzine. It also is dissolved by solutions of the fixed alkali hydroxides and soap solutions. Action and Uses: The action of cresol is similar to that of phenol except that it is stronger. It is a good disinfectant in the strength of 2 per cent solution for urinals, bedpans, stools, sputum cups, etc. It is used principally Preparation ; It is obtained from the phenol-distillates of coal tar. 224 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY in the form of Saponated Solution of Cresol, U. S. P. for disinfection of utensils, hands, and in obstetrical work, in strengths of from 1 to 3 per cent. The poisonous effects of cresol are similar to those of phenol and the treat- ment is the same as for phenol poisoning. Liquor Cresolis Saponatus, Saponated Solution of Cresol (Compound Solution of Cresol), U. S. P.—Preserve it in well-closed containers. It contains 50 per cent cresol in linseed-oil soap. Properties: It forms a clear solution with water. With water containing calcium or magnesium it forms a slightly cloudy solution due to the precipita- tion of insoluble soaps of these metals. Action and Uses: It is twice as strong as phenol as a germicide. It is less caustic but equally as poisonous as phenol. A weak aqueous (1 per cent) solu- tion is used as a vaginal douche. A 2 per cent aqueous solution may be used for disinfecting the hands. Instruments that cannot be boiled may be disinfected by using a 5 per cent aqueous solution. If accidentally swallowed, give an emetic followed by magnesium sulfate and demulcent drinks. Trinitrophenol, Trinitrophenol (Picric Acid), (C.iH20H(N02)3, U. S. P.—Pre- serve it in well-stoppered bottles, in a cool place, remote from fire. Caution: For safety in transportation it usually is mixed with about 20 per cent of water. Properties; It occurs in pale yellow, rhombic prisms or scales; odorless, and having an intensely bitter taste. Caution: It explodes when heated rapidly and when subjected to percussion. It is soluble in 78 parts of water, 12 parts of alcohol, 35 parts of chloroform, 65 parts of ether, and in 10 parts of benzene. Its aqueous solution is acid to litmus. Preparation : It is made by the action of nitric acid on phenol, resulting in the substitution of the nitro groups (N02) for three hydrogen atoms in phenol. Action and Uses: It is astringent and antiseptic. Its saturated aqueous solution is used mainly in the treatment of burns. Gauze saturated with the solution is applied to the burned area. A 5 per cent alcoholic solution is used (like tincture of iodine) in the first-aid treatment of wounds as a disinfectant. Picric acid solution should not be used in the treatment of burns covering a large area of the body as poisoning may occur. Resorcinol, Resorcinol (Resorcin), (C«H4(0H)2), U. S. P.—Meta-dihydroxyben- zene. It contains not less than 99.5 per cent of C«H4(OH)2. Preserve it in well- closed containers, protected from light. Properties: It occurs as colorless, or nearly colorless, needle-shaped crystals, or as a powder, having a faint peculiar odor and a sweetish, followed by bitter taste. It acquires a pink tint on exposure to air and light. It is soluble in 0.9 parts of water, 0.9 parts of alcohol, freely soluble in glycerin or ether, slightly soluble in chloroform. Actions and Uses: It is antiseptic and antizymotic. It seldom is given internally. It is used in the form of an aqueous solution, and an ointment in the treatment of subacute and chronic skin diseases. The action after absorp- tion is similar to that of phenol. Average dose: 0.125 Gm, or 2 grains. (Rarely given internally.) Creosotum, Creosote (Creasote), U. S. P.—A mixture of phenols obtained from wood tar. Preserve it in tightly-stoppered bottles, in a cool place and pro- tected from light. Properties : It is an almost colorless or yellowish, highly refractive, oily liquid, having a penetrating smoky odor, and a burning caustic taste; it does not readily become brown on exposure to light. It is slightly soluble in water, but is miscible with alcohol, ether, and fixed or volatile oils. It is inflammable. MATERIA MEDICA AND THERAPEUTICS 225 Action and Uses : It is given internally as an antiemetic, an expectorant, and an intestinal antiseptic. The poisonous symptoms are like those of phenol and the treatment is the same. Locally it acts as an anaesthetic and antiseptic which makes it suitable for use in dental practice to stop toothache. Average dose: 0.25 cc or 4 minims. When given freely it should be adminis- tered in emulsion or dissolved in milk in order to overcome its irritating local effect. / Creosoti Carbonas, Creosote Carbonate (Creosotal), U. S. P.—A mixture of the carbonates of various constituents of creosote. Properties: It is a clear, colorless or yellowish, viscid liquid, odorless and tasteless, or having a slight odor of creosote. It is insoluble in water and freely soluble in alcohol and fixed oils. Action and Uses: Being less irritating it is a good substitute for creosote internally. It is an expectorant. Average dose: 1 Gm. or 15 grains. Guaiacol, Guaiacol, U. S. P.—A liquid consisting principally of the mono- methylether (C«H4(OH) (OCH3)) of ortho-dihydroxybenzene obtained from wood- tar creosote, or a solid, consisting almost entirely of CoH4(OH) (OCH3), usually prepared synthetically. Properties : It is a colorless or yellowish, strongly refractive liquid or a crystalline solid having an agreeable aromatic odor. It is soluble in 60 to 70 parts of water, 1 part of glycerin, and is miscible with alcohol, chloroform, ether, and glacial acetic acid. Solid guaiacol melts at about 28° O. Preparation : It is made by the fractional distillation of wood-tar creosote. It also is made synthetically. Action and Uses : It is used externally as an antipyretic by applying locally on the skin; 1 to 3 cc painted on the chest, thigh, or abdomen of a fever patient will cause a fall of several degrees in the temperature of the body in an hour followed by excessive sweating and depression. It produces partial local anaesthesia when applied externally and sometimes is used for superficial neural- gias. It is used internally as an expectorant in bronchitis and tuberculosis. Acetophenetidinum, Acetophenetidin (Phenacetin), U. S. P.—The monoacetyl derivative (CsH4(OC2H5) .NH.CHsCO) of para-aminophenetol. Properties : It occurs as a white crystalline powder, odorless, and having a bitter taste. It is soluble in 1,310 parts of water and 15 parts of alcohol. Action and Uses: It is antipyretic, analgesic, and a cardiac depressant. It is used extensively as a headache remedy. Average dose: 0.5 cc or 8 minims. Average dose: 0.3 Gm. or 5 grains. Organic acids and their esters. Organic acids are compounds formed by the union of a hydrocarbon radical with a carboxyl group (COOH). They also are called carboxylic acids. They are not made by directly connecting the carboxyl group to a hydrocarbon radical but by the oxidation of an alcohol to an aldehyde, and further oxida- tion of the aldehyde to an organic acid. The reactions taking place in the formation of acetic acid from ethyl alcohol may be expressed as follows: 2C2H5.0H+02=2CH3.C0H+2IL0 ; then, 2CH3.C0H+02=20ILC00H. If the acid contains only one carboxyl group (COOH) it is a monobasic acid; if it con- tains two, it is a dibasic acid; if it contains three, it is tribasic, etc. The only hydrogen that is replaceable by a metal or basic radical in an organic acid is the hydrogen in the carboxyl group. They possess the general properties of inorganic acids; they are sour to the taste, usually soluble in water, and have a strong acid reaction to litmus. 226 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Some are liquids and some are solids. They are not as corrosive as the inorganic acids, some being very mild in their acid properties. They decom- pose carbonates and combine with metals and basic radicals to form salts. Esters are compounds formed by the union of an organic and inorganic acid !with a basic hydrocarbon radical. Erroneously they sometimes are called ethers. Examples of esters are ethyl acetate, ethyl chloride, phenyl salicylate, methyl salicylate, ethyl sulfate, etc. They frequently are called organic salts. Acidum Aceticum Glaciale, Glacial Acetic Acid, CH3.COOH, U. S. P.—A liquid containing not less than 99 per cent of CH3.COOH. Preserve it in glass- stoppered bottles. Properties : It is a clear, colorless liquid with a strong, vinegar-like, pungent odor and an acid taste. It is miscible with water or alcohol. Preparation : It is one of the products resulting from the destructive dis- tillation of wood. It may be made by oxidation of methyl alcohol. Action and Uses: It is a very energetic acid and acts as a caustic. It is used principally in the preparations of the weaker acids (acetic acid, U. S. P., 36 to 37 per cent, and diluted acetic acid, U. S. P., 5.7 to 6.3 per cent). It is used in the preparation of salts of acetic acid (acetates). When dropped upon the skin or mucous membranes it forms blisters and erodes the tissues beneath. It should be washed off the skin quickly with running water or soda solution. If swallowed accidentally give magnesium oxide mixed with water. Average dose: The 99 per cent acid is not given internally. The dose of the diluted acid is 2 cc or 30 minims. Acidum Benzoicum, Benzoic Acid, U.S.P.—It contains not less than 99.3 per cent of CgHs.COOH. It is found naturally in benzoin, balsam of tolu, balsam of Peru, storax, and other resinous substances from which it may be obtained by sublimation, but most of it is now produced synthetically. Preserve it in well-closed containers, in a cool place and protected from light. Properties : Colorless crystals, as scales or needles. It is odorless or may have a slight odor of benzaldehyde or benzoin. It is somewhat volatile when warmed. One gram is soluble in 275 cc of water, 2.3 cc of alcohol, and 3 cc of ether. It is soluble in fixed and in volatile oils. Action and Uses : In high dilutions it inhibits the growth of many organisms and in stronger solutions it is actively germicidal. It is sometimes used in mouth washes and is used in Whitfield’s Ointment with salycilic acid for ring- worm infections. It is stimulant, expectorant, and irritant to the mucous mem- branes. Benzoic acid and its salts, the benzoates, are used as food preservatives. Average dose: 1 Gm. or 15 grains administered in thick mucilage or syrup. Acidum Citricum, Citric Acid, U.S.P.—A tribasic organic acid usually obtained from the juice of limes or lemons. It contains not less than 99.5 per cent of C3H4(OH) (COOH)3 + H20. Preserve it in well-closed containers. Properties : It occurs as colorless, translucent crystals or as a white crystal- line powder, odorless and having an acid taste, and is efflorescent in dry air. It is soluble in 0.5 part of water and 1.8 parts of alcohol. Action and Uses: It is used in the preparation of citrates (solution of mag- nesium citrate, U. S. P.) and in the preparation of effervescent salts. It may be used as a substitute for lemon juice. Acidum Salicylicum, Salicylic Acid, U. S. P.—Orthohydroxybenzoic acid. It exists naturally in combination in various plants but generally is prepared synthetically. It contains, when dried at 100° C. for 2 hours, not less than 99.5 per cent of GeEMOEOCOOH, Preserve it in well-closed containers, in a cool place, protected from light. MATERIA MEDICA AND THERAPEUTICS 227 Properties : It occurs as colorless crystals, usually in fine needles, or a fluffy, white crystalline powder having a sweetish, afterwards acrid, taste. Synthetic salicylic acid is white and odorless; when prepared from methyl salicylate it may have a slight yellow tint and a slight gaultheria-like odor. It is soluble in 460 parts of water, 2.7 parts of alcohol, and 3 parts of ether. Action and Uses: Used as an antipyretic and antirheumatie. It is used principally in the preparation of the salicylates (phenyl salicylate, U. S. P., sodium salicylate, U. S. P., and acetylsalicylic acid) which are preferred for internal use. It is used externally for the treatment of skin diseases in the form of ointment, alcoholic solution, and dusting powder. It is used in skin diseases for its antiseptic effect and also its power of softening the horny, hard layer of the skin. It is contained in many corn collodions. Acidum Acetylsalicylicum, Acetylsalicylic Acid (Aspirin), U. S. P.—The acetyl derivative, of salicylic acid. Preserve it in well-closed containers. Average dose: 0.5 Gm. or 8 grains. Properties : It is a white crystalline powder or colorless crystals, odorless, and stable in dry air. It is sparingly soluble in water and freely soluble in alcohol. In moist air gradually hydrolizes into acetic and salicylic acids. It is decom- posed by alkalies. Action and Uses : It is used extensively as an antipyretic and antirheumatic. It is an excellent headache remedy. It must be used with caution because some individuals are easily poisoned by it, due probably to an idiosyncrasy. It should not be dispensed in solution because its aqueous solution slowly de- composes on standing. Average dose: 0.3 Gm. or 5 grains. Phenylis Salicylas, Phenyl Salicylate (Salol), U. S. P.—The phenyl ester (C.jHi (OH) COOCTIb) of salicylic acid. Preserve it in wrell-closed containers in a cool place, and protected from light. Properties: A white crystalline powder, having an aromatic odor and a characteristic taste. It is practically insoluble in water, soluble in 6 parts of alcohol, very soluble in chloroform, ether, and fixed or volatile oils. Preparation: It is made by the action of dehydrating agents on a heated mixture of phenol and salicylic acid. Action and Uses: It is used as an Intestinal antiseptic. In the intestine, when in contact with alkaline fluids, it is decomposed into its component parts of phenol and salicylic acid which there exert their antiseptic action. It is given with bismuth subnitrate for diarrhoea. It passes through the stomach unchanged, but breaks down in the intestine, and because of this property it is used for coating enteric pills, protecting them from the action of the stomach juices. Average dose: 0.3 Gm. or 5 grains. Acidum Tannicum, Tannic Acid (Tannin, Gallotannic Acid), U. S. P.—A tannin usually obtained from nutgall. Preserve it in well-closed containers in a cool place, protected from light. Properties : It is a yellowish-white to light brown, amorphous powder, glistening scales, or spongy masses, nearly odorless, and having a strong astringent taste. It is soluble in 1 part of glycerin and is very soluble in water or alcohol. Action and Uses: It is an astringent, and haemostatic. It is used in the form of an ointment for the treatment of haemorrhoids and in an aqueous solution as an astringent mouth wash and gargle. It is an alkaloidal precipi- 228 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tant and may be used as a chemical antidote in certain cases of alkaloidal poisoning. It is used extensively in the treatment of burns in the form of an aqueous solution or a jelly. It acts as an astringent, hinders the growth of bacteria, and “tans” the tissues in the burned areas, forming a crust over them which prevents the escape of fluids from the body. Fantus and Dyniewicz in the Journal of the American Medical Association of July 17, 1937, favorably report the use of Compound Solution of Tannic Acid in the treatment of burns and state that the solution does not decompose and may be kept on hand for use in the emergencies occasioned by extensive burns, the salicylic acid pre- venting deterioration. Following is their formula: Potassium chloride 0. 42 Gm. Calcium chloride 0. 84 Gm. Acid salicylic 1. 00 Gm. Sodium chloride 10. 50 Gm. Acid tannic 100. 00 Gm. Distilled water to make 1, 000. 00 cc Mix and permit to stand with occasional agitation until dissolved; filter. Two formulas for the preparation of tannic-acid jelly are given in which phenol is used to prevent deterioration. Both may be prepared in quantity to be kept on hand for use in emergency. 5 per cent Tannic-Acid Jelly with Tragacanth and % per cent Phenol Phenol 0. 500 Tragacanth 3. 000 Glycerin 42. 500 Alcohol, 95 per cent 8. 000 Tannic acid 5. 000 Menthol , O'. 080 Distilled water 79. 000 Dissolve tannic acid in the water, add the glycerin and phenol, and heat until the solution is hot. Dissolve menthol in the alcohol. Mix the tragacanth with the alcoholic solution and while stirring add the aqueous solution. Continue stirring until a uniform jelly results. 5 per cent Tannic-Acid Jelly with Starch and % per cent Phenol Tannic acid 5. 000 Phenol 0. 500 Starch 5. 500 Glycerin 42. 000 Distilled water 47. 000 Mix the starch with 10 cc of cold water. Mix the glycerin and the remaining water, dissolve the tannic acid and the phenol in this solution and heat to boiling. Continue the boiling, hdd all the starch mixture at once, and stir until a homogeneous jelly results before removing from heat. Note: Failure to jell will usually be due to withdrawal of heat too soon after starch mixture is added. Acidum Tartaricum, Tartaric Acid, U. S. P.—A dibasic organic acid obtained from impure acid potassium tartrate (argol) in wine lees, by the action of MATERIA MEDICA AND THERAPEUTICS 229 calcium carbonate and sulfuric acid on acid potassium tartrate, or by synthesis. It contains not less than 99.5 per cent of G-H- (OH)2 (COOH)2. Pkopeeties : It occurs in colorless, translucent crystals, or as a white, fine to granular crystalline powder, odorless, and having an acid taste. It is soluble in 0.75 parts of water, 3 parts of alcohol, and almost insoluble in chloroform and ether. It is stable in the air. Preparation : It is made from the deposit in wine casks, which is composed principally of acid potassium tartrate. This acid potassium tartrate is con- verted into normal calcium tartrate (insoluble) in order to remove other impurities, then the pure calcium tartrate is treated with sulfuric acid, forming calcium sulfate and tartaric acid. The calcium sulfate is precipitated and the tartaric acid remains in solution, from which it is obtained by filtration and evaporation. Action and Uses : It is used in the preparation of effervescent salts and drinks. It is contained in the white packet of a Seidlitz powder. Salts of tartaric acid are laxative (cream of tartar and Rochelle salt). Cinchophenum, Cinchophen, N. F.—Cinchophen contains, when dried to con- stant weight at 100° C., not less than 99.5 per cent of phenyl-quinoline-car- boxylic acid (OsHsN.CeHs.COOH). Average dose: 0.5 Gm. or 8 grains. (Rarely given internally.) Properties : It occurs in small, white or almost white, needle-like crystals or a fine powder, odorless, and has a bitter taste. It is stable in the air, is almost insoluble in cold water, but slightly soluble in hot water; slightly soluble in cold alcohol, but more readily soluble in hot alcohol. Action and Uses: This compound is sold under the trade name of Atophan. It stimulates the kidneys to excrete morel urine and has a selective action on the excretion of uric acid, which is increased in greater ratio than the increase in the amount of urine. Because of this selective action in increasing uric acid elimination it is used in the treatment of gout. Care must be taken in using it because it may cause damage to the kidney and sometimes has a dangerous effect on the liver. Amylis Nitris, Amyl Nitrite, U. S. P.—A liquid containing not less than 80 per cent of CsHuONO. Preserve it in hermetically sealed glass bulbs or tightly stoppered vials, in a cool place, protected from light. Average dose: 0.05 Gm. or 8 grains. Properties : It is a clear, yellowish liquid, of a peculiar ethereal, fruity odor and a pungent, aromatic taste. It is almost insoluble in water, but is miscible with alcohol or ether. It is very volatile even at low temperatures and is inflammable. Action and Uses: Amyl nitrite, like other nitrites (glyceryl nitrite, etc.), is a vasodilator (dilates the blood vessels). Amyl nitrite is given by inhalation to relax spasms of blood vessels in angina pectoris, asthma, and other painful affections due to arterial spasms. It is supplied to the Navy in the form of glass pearls (ampules) containing 5 minims each. When it is to be administered the pearl is crushed in a handkerchief and the volatile amyl nitrite inhaled. Its action is almost instantaneous. Average dose: 0.2 cc or 3 minims by inhalation. Spiritus .ffithylis Nitritis, Spirit of Ethyl Nitrite (Sweet Spirit of Nitre), U. S. P.—An alcoholic solution of ethyl nitrite (C2HsONO) containing not less than 3.5 per cent nor more than 4.5 per cent of C2H5ONO. Preserve it in well-filled, small, tightly-stoppered bottles, in a cool and dark place, remote from fire. Properties : It is a clear, mobile, volatile, and inflammable liquid of a pale yellow or faintly greenish-yellow tint, having a fragrant, ethereal, and pungent 230 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY odor, free from acridity, and a sharp, burning taste. When kept for a long time, or upon exposure to light and air, it acquires an acid reaction. Action and Uses : It is a diuretic and diaphoretic. It is one of the ingredi- ents contained in Brown Mixture. It frequently is given with solution of ammonium acetate. Average dose: 2 cc or 30 minims. Volatile oils, volatile-oil drugs, and preparations made from volatile-oil drugs Volatile oils are a class of substances having in common the properties of being volatile and almost insoluble in water; most of them are lighter than water, are soluble in ether and alcohol, have a highly characteristic odor, and possess antiseptic properties. They do not leave a permanent stain on paper like that left by a fixed oil. Most of them are obtained from plants where they exist naturally or are formed when the plant is brought in contact with water. They vary greatly in their chemical composition. The follow- ing classes of chemical compounds are found in volatile oils: Hydrocarbons, alcohols, aldehydes, esters, ketones, phenols and phenol derivatives, sulfur com- pounds, etc. All these classes of compounds are not found in any one oil but a volatile oil may contain one or more compounds belonging to one or more of the classes named. Oil of peppermint contains menthol which is an alcohol; oil of thyme contains thymol, which is a phenol; oil of gaultheria contains methyl sal- icylate, which is an ester, etc. The medicinal properties of the volatile oils vary greatly, due to the difference in their chemical composition. Oleum Menthae Piperitae, Oil of Peppermint (Peppermint Oil), U. S. P.—A volatile oil distilled from the flowering plant of Mentha piperita, rectified by steam distillation, and yielding not less than 5 per cent of esters, calculated as menthyl acetate and not less than 50 per cent of total men- thol (CioHri.OH), free and as esters. Preserve it in well-stoppered bottles, in a cool place, protected from light. Properties : It is a colorless liquid, having a strong odor of peppermint and a pungent taste, followed by a sensation of cold when air is drawn into the mouth. It is very slightly soluble in water, but is soluble in 4 parts of 70 per cent alcohol. Action and Uses : It is used as a flavoring, and as an aromatic stimulant and carminative. It is contained in Soda Mint Tablets. Average dose: 0.1 cc or iy2 minims. Menthol, Menthol, U. S. P.—An alcohol (CioHwOH), obtained from oil of pep- permint or other mint oils, or prepared synthetically. Preserve it in well-closed containers in a cool place, protected from light. Properties: It occurs in colorless, hexagonal crystals, usually needle-like, having a strong odor and taste like peppermint. When tasted it produces a sen- sation of warmth followed by cold when air is drawn into the mouth-. It is slightly soluble in water; very soluble in alcohol, chloroform, ether, or in petro- leum benzine; freely soluble in liquid petrolatum, fixed or volatile oils. When triturated with about an equal weight of camphor, thymol, or hydrated chloral the mixture becomes liquid. Preparation : It is made by placing oil of peppermint in a freezing mixture; when the temperature reaches —22° C. the menthol precipitates from the oil. Action and Uses : Externally it is applied to the skin as a local anaesthetic and cooling application for the relief of superficial neuralgias. It is exten- sively used in nose and throat sprays. It is applied in solution or ointment for the relief of itching skin diseases. Average dose: 0.06 Gm. or 1 grain. MATERIA MEDICA AND THERAPEUTICS 231 Spiritus Aurantii Compositus, Compound Spirit of Orange, U. S. P.—It con- tains oil of orange, oil of lemon, oil of coriander, oil of anise, and alcohol. It should be kept in completely filled, well-stoppered bottles in a cool, dark place. Action' and Uses: It is used as a flavoring and in the preparation of aromatic elixir. Oleum Caryophylli, Oil of Clove (Oil of Cloves, Clove Oil), U. S. P.—A vola- tile oil distilled from the dried flower buds of Caryophyllus aromaticus and yielding not less than 82 per cent, by volume, of eugenol (C10H12O2). Preserve it in well-stoppered bottles, in a cool place, protected from light. Properties : It is a colorless or pale yellow liquid, becoming darker and thicker by age and by exposure to air, having the odor and taste of clove. It is soluble in two parts of 70 per cent alcohol. Action and Uses : Internally it acts as a stimulant and carminative. Ex- ternally it is employed as a local anaesthetic, parasiticide, and counterirritant. In dental practice it is used to stop toothache by applying it, on a piece of cotton, to a previously cleaned tooth cavity. In microscopy it is used to clear tissues for mounting. Average dose: 0.1 cc or 1% minims. (When given internally it should be diluted with five times its volume of cottonseed oil.) Eugenol, Eugenol, U. S. P.—An unsaturated, aromatic phenol, C0H3.C3H5. OOHs.OH, obtained from oil of clove and from other sources. Preserve it in well-closed containers, in a cool place, protected from light. Properties : It is a colorless or pale yellow, thin liquid, having a strongly aromatic odor of clove and a pungent and spicy taste. It becomes darker and thicker on exposure to air. It is soluble in two parts of 70 per cent alcohol; miscible with alcohol, chloroform, ether, or fixed oils. Action and Uses: It is used in dental practice as a substitute for oil of clove. Average dose: 0.1 cc or 1% minims. Tinctura Cardamomi Composita, Compound Tincture of Cardamom, U. S. P.— It contains the aromatic, carminative principles from cardamon seed, cinnamon, and caraway. It is colored red with cochineal. The menstruum is diluted alcohol containing a little glycerin. Action and Uses: It is used as a carminative and flavoring agent. Average dose: 0.4 cc or 1 fluidram. Oleum Picis Rectificatum, Rectified Oil of Tar, U. S. P.—A rectified volatile oil distilled from pine tar. Properties : It is a liquid having a reddish brown color and a strong, empy- reumatic odor and taste. It is soluble in alcohol and insoluble in water. Preparation : It is made from wood tar by subjecting it to distillation and collecting that portion of the distillate which is lighter than water. It is a mixture of phenols, hydrocarbons, acetic acid, and oil of turpentine. Action and Uses : It is given internally in the treatment of chronic bron- chitis, administered in the form of an emulsion; externally it is used in the treatment of skin diseases, in the form of an ointment. Average dose: 0.2 cc or 3 minims. Eucalyptol, Eucalyptol (Cineol), U. S. P.—An organic compound (CwHisO) obtained from the volatile oil of Eucalyptus Globulus and from other sources. Preserve it in well-closed containers, in a cool place protected from light. Properties : It is a colorless, oily liquid, having a characteristic, aromatic, and distinctly camphoraceous odor, and a pungent, spicy taste, It is very slightly 232 HANDBOOK OF THE HOSPITAL CORPS, XT. S. NAVY soluble in water, miscible with alcohol, chloroform, ether, glacial acetic acid, and fixed or volatile oils. Action and Uses : It is a stimulant expectorant, mild antiseptic, and anthel- mintic. It is given in the treatment of chronic bronchitis and pulmonary tuber- culosis. A mixture of 2 parts eucalyptol, 4 parts chloroform, and 45 parts of castor oil is used internally (given in two doses) in the treatment of uncinariasis (hookworm). Used locally in throat and nasal sprays and in the treatment of chronic skin diseases. Average dose: 0.3 cc or 5 minims. Fluidextractum Zingiberis, Fluidextract of Ginger, U. S. P.—Each 100 cc of the fluidextract contains not less than 4.5 Gm. of ether-soluble extractive, and each cc represents the medicinal activity of 1 gram of the drug (ginger). The active substances in ginger are a volatile oil and an aromatic resin. Action and Uses: It is used in the preparation of syrup of ginger. It acts as a warm, stimulating carminative when taken internally and is a valuable remedy in the treatment of abdominal cramps. Average dose: 0.5 cc or 8 minims (diluted with water). Camphora, Camphora, U. S. P.—A ketone (CaHieCO) obtained from Cinnamo- mum Camphora, or produced synthetically. Preserve it in well-closed contain- ers in a cool place, protected from light. Properties ; It occurs as white, translucent masses of granules of a tough consistence having a penetrating, characteristic odor and a pungent, aromatic taste. It is readily pulverizable in the presence of a little alcohol, ether, or chloroform. It is slightly soluble in water and freely soluble in alcohol, chloro- form, ether, or in fixed or volatile oils. Preparation: It is obtained by treating the branches and chipped wood of the camphor tree with steam. The camphor in the wood is volatilized by the hot steam and then condensed. Action and Uses: It is a circulatory stimulant, mild antiseptic, slight rube- facient, and carminative. As a circulatory stimulant it is given hypodermically in sterilized oil. It is used as a mild antiseptic in nose and throat sprays, as a rubefacient in liniments, and as a carminative in diarrhoea mixtures (Squibb’s Diarrhoea Mixture). Average doses: By mouth 0.2 Gm. or 3 grains; by hypodermic 0.1 Gm. or 1 % grains. Methylis Salicylas, Methyl Salicylate (Oil of Teaberry. Oil of Wintergreen, Oil of Sweet Birch), U. S. P.—It contains not less than 98 per cent of CelUtOIDCOO.CHs. It is produced synthetically or is obtained by distillation from Gaulthcria procumbens or from Betula lenta. The label must indicate whether the methyl salicylate has been made synthetically or distilled from either of the plants mentioned. Preserve it in well-stoppered bottles in a cool place, protected from light. Properties : It is a colorless, yellowish or reddish liquid having the charac- teristic odor and taste of gaultheria. It is sparingly soluble in water, miscible with alcohol and glacial acetic acid, and is soluble in 7 parts of 70 per cent alcohol. Action and Uses: It is antirheumatic and slightly antiseptic. Given inter- nally its antirheumatic action is like that of the other salicylates. It is rapidly absorbed when rubbed on the skin or applied to the skin on a cloth. It is applied locally for the relief of rheumatic pains in the joints. The synthetic oil is on the Supply Table. It is cheaper than the natural oil and is believed to be identical in its medicinal properties. Average dose: 0.75 cc or 12 minims. MATERIA MEDICA AND THERAPEUTICS 233 Thymol, Thymol, U. S. P.—A phenol (Cells(CH3) (OH) (C3H7) oecuring in the volatile oil of Thymus vulgaris and in some other volatile oils. Preserve it in well-closed containers. Properties : It occurs in large colorless crystals, having an aromatic, thyme- like odor and a pungent, aromatic taste, with a slight caustic effect upon the lips. It is soluble in 1,000 parts of water, 1 part of alcohol, 0.7 part of chloro- form, 1.5 parts of ether, 1.7 parts of olive oil, and in glacial acetic acid and in fixed or volatile oils. When triturated with about an equal weight of camphor or menthol, the mixture liquefies. Action and Uses: Thymol is used as an anthelmintic and antiseptic. As an antiseptic it is employed in mouth washes, gargles, and sprays. As an anthelmintic it is given for the cure of hookworm disease. Oils should not be given while thymol is in the intestinal tract because they cause it to be absorbed, with resulting symptoms of poisoning. Its administration should be preceded and followed by administrations of magnesium sulfate. Average dose: Antiseptic, 0.125 Gm. or 2 grains; anthelmintic, 1 Gm. or 15 grains. Thymolis lodidum, Thymol Iodide (Aristol), U. S. P.—Chiefly dithymoldi- iodide (O0H2.CH3.C3H-.01). It contains, when dried to constant weight over sulfuric acid, not less than 43 per cent of iodine. Preserve it in well-closed containers, protected from light. Properties : It is a reddish-brown, or reddish-yellow bulky powder with a very slight, aromatic odor. It is insoluble in water or glycerin; slightly soluble in alcohol and very soluble in chloroform, ether, and in fixed or volatile oils. Preparation : It may be made by adding an aqueous solution of iodine and potassium iodide to an aqueous solution of sodium hydroxide and thymol with constant stirring. Thymol iodide is precipitated from this mixture. Action and Uses: It is a valuable antiseptic dusting powder. It is used in surgery as a substitute for iodoform, and as an external application to ulcers and skin diseases, either in the form of dry powder or ointment. It commonly is known as Aristol. Emplastrum Sinapis, Mustard Plaster (Mustard Paper), U. S. P.—A uniform mixture of powdered black mustard (deprived of its fixed oil) and a solution of rubber, spread on paper, cotton cloth, or other fabric. It should be one square decimeter (16 square inches) in size and contain not less than 2.5 grams of black mustard deprived of its fixed oil. Properties: When moistened thoroughly with tepid (not hot) water and applied to the skin, the plaster produces a decided warmth and reddening of the skin within 5 minutes. The irritating effect is produced by the volatile oil of mustard. This oil is liberated when mustard is mixed with water. Action and Uses : It is an extensively used counterirritant. It is used for the relief of congestion and pain in the chest, abdomen, joints, or muscles. Tinctura Capsici, Tincture of Capsicum, U. S. P.—It is a 10 per cent tincture, made by exhausting the active principles contained in Cayenne pepper with alcohol. It has a light reddish color and the fiery taste of Cayenne pepper. Action and Uses : Taken internally it stimulates the secretions of the salivary, gastric, and intestinal glands. It is especially valuable in gastritis due to alcoholism. Oleum Santali, Oil of Santal (Santalwood Oil, Oil of Sandalwood), U. S. P.— A volatile oil distilled from the dried heart-wood of Santalum album, yielding pot less than 90 per cent of alcohols, calculated as santalol (C10H2A)). Preserve Average dose: 0.5 cc or 8 minims. 234 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY it in well-stoppered, amber-colored bottles in a cool place, protected from light. Properties : It is a pale yellow, somewhat viscid, oily liquid; soluble in 5 parts of 70 per cent alcohol and having the characteristic odor and taste of sandal- wood. Action and Uses: It is given internally as a stimulant and disinfectant to the mucous membranes of the genito-urinary tract. In overdoses it is very irritating to the genito-urinary tract, and therefore should be given with care. Its principal use is in the treatment of chronic gonorrhoea. Average dose: 0.5 cc or 8 minims (in capsules, three times a day). Resins, oleoresins, gum-resins, balsams, and their preparations. Resins are natural, solid or semisolid plant exudations which usually are the oxidation products of the terpene group of volatile oils. They are complex in chemical composition, in which they show no uniformity, and apparently have as their chief constituents resin acids, resin esters, and resenes. Some are acid in character and form resin soap when combined with alkalies. They are hard, brittle, noncrystalline solids, fusible but not volatile, insoluble in water but soluble mostly in alcohol and ether, have little taste, burn with a smoky flame when ignited in the air, and soften or melt at moderate tempera- tures. They are transparent when pure but when they contain water are opaque and no longer hard and brittle. Resins are known as natural resins which occur as plant exudations, and prepared resins which are made in various ways. See under Resina1 in chapter on Pharmacy). Oleoresins are of two types, natural and prepared. Natural oleoresins are mixtures of volatile oil and resin and are obtained generally from natural fissures or from incisions made in the trunks of the trees in which they occur. (For prepared oleoresins see under Oleoresins in chapter on Pharmacy). Gum-resins are natural plant exudations composed of gum and resin. The gummy plant substances called gums are amorphous (shapeless), transparent or translucent, probably glucosidal in nature, and as the chemical composition of some of their constituents is similar to starch are classified with carbohy- drates (see under Sugars and substances containing sweet principles, p. 241). They are all insoluble in alcohol (differing in this respect from resins), some are completely soluble in water, others swell in water and form a paste or jelly, and a few are almost insoluble. When gum-resins are rubbed up with water they form an emulsion as the gum dissolves to form a mucilage which holds the resin in suspension. Balsams are natural oleoresins which contain benzoic or cinnamic acids or their esters, or other aromatic acids. When a natural resin contains benzoic or cinnamic acids and is therefore aromatic, it is known as a balsamic resin. Oleum Terebinthinse, Oil of Turpentine (Spirits of Turpentine), U. S. P.—The volatile oil distilled from the oleo-resin obtained from Pinus palustris and other species of Pinus. Preserve it in well-closed containers. Properties : It is a colorless liquid having a characteristic odor and taste, both of which become stronger and less pleasant on aging or exposure to the air. Almost insoluble in water but soluble in 5 parts of alcohol. Action and Uses; The rectified oil of turpentine, U. S. P., should be used internally and oil of turpentine externally. When given internally it acts as a diuretic, expectorant, and anthelmintic. Externally it is used as a counter- irritant and rubefacient. Average dose: 0.3 cc or 5 minims (of the rectified oil). Terpini Hydras, Terpin Hydrate, U. S. P.—The hydrate (GioHiS(OH)2-f H20) of the dihydric alcohol terpin. Preserve it in well-closed containers, in a cool place, and protected from light. MATERIA MEDICA AND THERAPEUTICS 235 Properties : It is a colorless, lustrous, white powder, almost odorless, having a slight aromatic and bitter taste. It is soluble in 200 parts of water and in 13 parts of alcohol. It effloresces in dry air. Action and Uses: It has a stimulating action upon mucous membranes. Its action is expectorant, diuretic, and slightly antiseptic. Its principal use is as an expectorant in the treatment of chronic bronchitis. It is administered in the form of an elixir. Average dose: 0.25 Gm. or 4 grains. Tinctura Myrrhse, Tincture of Myrrh, U. S. P.—-It is made by extracting by maceration, the soluble principles from 200 Gm. of powdered myrrh with sufficient alcohol to obtain 1,000 ce of finished tincture. Properties: It is a dark reddish-brown liquid, having the balsamic odor of myrrh, and a bitter, aromatic taste. When mixed with water the resin con- tained in the alcoholic solution is precipitated. Myrrh is a gum resin and con- tains 3 to 8 per cent of an oxygenated volatile oil, a bitter principle, about 50 to 60 per cent of gum, and 25 to 40 per cent of resin. Action and Uses : It is an astringent. It is rarely used internally. It is used locally as a mouth wash, diluted with water in the proportion of about 1 to 20, in the treatment of stomatitis, spongy gums, sore throat, ptyalism, etc. Average dose: 1 cc or 15 minims. Balsamum Peruvianum, Peruvian Balsam (Balsam of Peru, Peru Balsam, In- dian Balsam, U. S. P.—A balsam obtained from Toluifera Pereirce. It contains about 60 per cent of a volatile oil and about 30 per cent of resin. Properties : It is a viscid liquid of a dark-brown color having an agreeable, vanilla-like odor, and a bitter, acrid taste. It is almost insoluble in water, soluble in alcohol or chloroform, and partly soluble in ether. Action and Uses : 95 per cent solution in castor oil is used as a stimulating dressing for sluggish granulations and chronic indolent ulcers. It is a valuable parasiticide in ringworm, pediculosis (crab lice), and scabies; for this purpose it is used in the form of an ointment consisting of 20 parts balsam of Peru, 50 parts cottonseed oil, and 100 parts petrolatum. In the treatment of scabies it is used like sulfur ointment (hot bath before, etc.). There may be added to this ointment 10 per cent of sulfur to increase its efficiency in the treatment of scabies. Tinctura Benzoini Composita, Compound Tincture of Benzoin (Friars’ Balsam), U. S. P.—It is a dark-brown alcoholic liquid, made by extracting, by maceration, the alcohol-soluble principles from benzoin, 100 Gm.; aloes, 20 Gm.; storax, 80 Gm.; and balsam of tolu, 40 Gm., with sufficient alcohol to make 1000 cc of finished tincture. Action and Uses ; It is used in steam atomizers as 'an inhalant in the treat- ment of croupous affections of the throat and bronchi. If a steam atomizer is not available, the inhalations may be given by adding a teaspoonful of tincture to h glassful of boiling water and inhaling the vapor. It also is used as a protective for ulcers, fissures of the lips and anus, bedsores, cracked nipples, etc. It rarely is used internally. Average dose: 2 cc or 30 minims. Oleoresina Aspidii, Oleoresin of Aspidium (Oleoresin of Male Fern), U. S. P.—Made by extracting the ether-soluble principles from Aspidium by percola- tion with a menstruum of ether. After percolation the ether is evaporated off, leaving the oleoresin of aspidium. It should be preserved in well-stoppered bottles. On standing, there is deposited in the bottom of the bottle a granular crystalline substance which should be thoroughly mixed with the liquid portion before use. 154294°—39 16 236 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Action and Uses: Used as a taeniacide (kills tapeworms). Castor oil or other fixed oils should not be given while oleoresin of aspidium is in the intestinal tract, because they cause absorption of the oleoresin and thus may cause toxic symptoms. Average dose: 4 Gm. or 60 grains. Only one dose a day. Fixed oils, fats, and soaps. Fixed oils are so called because they leave a stain on paper or cloth that will not wash out, nor will it volatilize when subjected to mild heat. In this re- spect they differ from volatile oils. Solid substances that leave a similar stain are called fats. Fixed oils are found principally in the vegetable kingdom, and the fats are obtained from the animal kingdom. Fixed oils and fats are classed together because of the close chemical relationship that exists between them. They are composed principally of mixtures of glycerides of organic acids (esters). The principal acids that are combined with glyceryl radicals (C3H5) in these glycerides are: Oleic, palmitic, stearic, linoleic, and ricinoleic. The glycerides of these acids are liquids, except those of stearic and palmitic acids. Most fats and oils in common use are composed of glycerides of two or more of the above acids. The consistence of a fat or oil is governed by the propor- tion in which the solid and liquid glycerides are contained in it. Cottonseed oil is composed principally of glyceryl oleate (olein), while beef tallow, a solid, is composed principally of glyceryl stearate (stearin), etc. If the basic glyceryl radical (C3H5) in a glyceride is displaced by an alkali metal, like sodium, sodium stearate, sodium oleate, or sodium palmitate (soaps) are formed accord- ing to the acid in the glyceride; the glyceryl radical (C3H5) is set free to com- bine with hydroxyl (OH) groups that were attached to the sodium and form glycerin. This reaction is known as saponification. Rancidity is a condition in fixed oils and fats due to decomposition of the glycerides under the influence of air (oxygen), heat, and albuminous matter, resulting in the liberation of the fatty acids and generation of volatile acids that have a distinct odor. Oleum Gossypii Seminis, Cottonseed Oil, U. S. P.—A fixed oil obtained from seeds of cultivated varieties of Gossypium herbaceum, or other species of Gos- sypium. It is made by expression. Preserve it in well-closed containers, protected from light. Properties : It is a pale, yellow, oily liquid, odorless or nearly odorless, and having a bland taste. It is almost insoluble in water; slightly soluble in alcohol; and is miscible with ether, chloroform, and petroleum benzine. It is readily saponified by strong solutions of alkalies forming soap. Action and Uses: It is used in the preparation of liniments. Cottonseed oil and its derivatives are used extensively as food products. It also is used in large quantities in the manufacture of soap. Oleum Ricini, Castor Oil, U. S. P.—A fixed oil obtained from the seeds of Ricinus communis. Preserve it in well-closed containers. Average dose: 8 cc or 2 fluidrams. Properties : It is a pale-yellowish or almost colorless, transparent, viscid liquid, having a faint, mild odor and a bland, afterwards slightly acrid and generally nauseating taste. It is almost insoluble in water and is soluble in equal parts of alcohol and in one and one-half times its volume of liquid petrolatum. Action and Uses: It is used extensively as a simple purgative. It increases the intestinal secretions and stimulates the peristaltic movements of the intes- tine. Its disagreeable taste may be disguised partially by administering it 237 MATERIA MEDICA AND THERAPEUTICS between a layer of peppermint water below and a layer of compound tincture of cardamon above the oil. Average dose: 15 cc or 4 fluidrams. Oleum Morrhuse, Cod Liver Oil (Oleum Jecoris Aselli), U. S. P.—The partially destearinated fixed oil obtained from the fresh livers of Oadus morrhua (cod- fish) and other species of the family Gadidw. Cod Liver Oil contains in each gram at least 600 U. S. P. Units of Vitamin A and at least 85 U. S. P. Units of Vitamin D. Preserve it in a cool place in well-closed containers which have been thoroughly dried before filling. Properties : It is a thin, oily liquid, having a peculiar, slightly fishy, but not rancid odor, and a fishy taste. It is almost insoluble in water but is slightly soluble in alcohol. Preparation ; The oil is obtained from the fresh fish livers by boiling them with water and skimming off the separated oil. Action and Uses : It is used as a tonic in the treatment of wasting diseases. The ease with which it is assimilated makes it an excellent food. Its bene- ficial effects are due principally to the presence of large amounts of Vitamin A and Vitamin D. Cod Liver Oil is also used as a local application to promote healing of burns on the body. Average dose: 10 cc or 2% fluidrams. Liquor Ergosterolis Irradiati, Solution of Irradiated Ergosterol (Viosterol in Oil), U. S. P.—A solution of ergosterol in corn oil, activated by irradiation with ultraviolet rays. It contains in each gram not less than 10,000 U. S. P. Units of Vitamin D. Properties : A clear, light yellowish, oily liquid. It is almost odorless and has a bland taste. It should be preserved in small, well-stoppered bottles, in a cool place. Action and Uses : It is used in prophylaxis and treatment of rickets and infantile tetany, and in other conditions due to faulty calcium and phosphorus assimilation. This preparation does not contain any Vitamin A, Care must be exercised in giving this preparation to avoid hypercalcsemia caused by large doses over a long period. Average dose: 0.3 cc or 5 minims. Note.—Through biochemical investigation into the physiological action of Vitamin D it was discovered that when food mixtures which caused the production of rickets in young animals were exposed to ultraviolet rays they became endowed with properties protecting the animals against the disease. Further research disclosed that the protective properties were concerned with a constituent of the fatty part of the ration and this constituent was finally found to be a substance known as ergosterol. Ergosterol was originally isolated as a constituent of ergot but is now obtained from other substances, mainly yeast. Either in crystalline form or in solution, when it is subjected to care- fully regulated ultraviolet radiation, ergosterol develops an antirachitic (Vita- min D) potency enormously greater than that of Cod Liver Oil. The Council of Pharmacy and Chemistry of the American Medical Association has adopted the term Viosterol to designate irradiated ergosterol, and Viosterol in Oil to designate a preparation containing this substance dissolved in a vegetable oil. Halibut Liver Oil with Viosterol, N. N. R.—Halibut Liver Oil to which has been added sufficient viosterol (irradiated ergosterol) to assure a potency of not less than 9,000 Vitamin D units (U. S. P. X-Revised, 1984) per gram; the halibut liver oil is adjusted (when necessary) to have a Vitamin A potency of 238 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY not less than 44,800 units (U. S. P. X-Revised, 1934) of Vitamin A per gram by the addition of fish liver oils. Action and Uses: The action and use are the same as for Cod Liver Oil. This preparation is much richer in both Vitamin A and Vitamin D than Cod Liver Oil and the dose is correspondingly smaller. Average dose: For infants 10 drops daily and for adults 20 drops daily. Oleum Theohromatis, Theobroma Oil (Cacao Butter, Cocoa Butter, Oil of Theobroma), U. S. P.—The fat obtained from the roasted seed of Theobroma Cacao. Preserve it in a cool place. Properties: It is a yellowish-white solid, having a faint, agreeable odor, and a bland, chocolate-like taste. It is insoluble in water, slightly soluble in alcohol, and freely soluble in ether or chloroform. It melts between 30° and 35° C. (86° and 95° F.). It is usually brittle at temperatures below 25° C. Action and Uses: It is used as a vehicle in the preparation of suppositories because it melts slightly below the temperature of the body, sets free any medicinal substance incorporated with it, and allows the medicine to come in contact with the mucous membranes. It also is used in the preparation of skin foods (ointment-like preparations) and as a lubricant in massage. It is not given internally. Adeps, lard, U. S. P.—The purified Internal fat of the abdomen of the hog. Preserve it in a cool place in well-closed containers which are impervious to fat. Adeps benzoinatus, (benzoinated lard), U. S. P., is a lard that has been treated with Siam benzoin to prevent it from turning rancid. In the prepa- ration of benzoinated lard for use in warm climates the Pharmacopoeia states that 50 Gm. of white wax (or more if necessary) may replace an equal amount of the lard in order to raise its melting point. Supply Table lard contains 12 per cent of white wax. Properties : Lard is a soft, unctuous mass having a faint odor and a bland taste, and free from rancidity. It melts between 36° and 42° O., is insoluble in water, slightly soluble in alcohol, and readily soluble in ether, chloroform, and petroleum benzine. Action and Uses: Benzoinated lard is used principally as an ointment base. Adeps Lanse, Wool Fat (Anhydrous lanolin, Refined Wool Fat), U. S. P.— The purified, anhydrous, fat-like substance obtained from the wool of the sheep. Preserve it in a cool place in well-closed containers which are impervious to fat. Properties: It is a brownish-yellow, tenacious, unctuous mass having not more than a slight odor. It is insoluble in water, but mixes with its own weight of water without losing its ointment-like character. Action and Uses : It is used principally as an ointment base. It will permit 100 per cent of its weight of water to be incorporated with it, which makes it an excellent base to use when a large volume of an aqueous liquid is to be incorporated in an ointment. Unlike lard and most other animal fats, it does not turn rancid. Cera Alba, White Wax, U. S. P.—It is yellow wax which has been bleached. Properties : It is a yellowish-white solid, somewhat translucent in thin layers, having a faint characteristic odor, practically tasteless, and free from rancidity. Action and Uses: It is used to stiffen ointments in warm climates, and it also is used in the preparation of cerates (stiff ointments). It is sometimes adulterated wth paraffin. Sapo Durus, Hard Soap, U. S. P.—Soap prepared from olive oil and sodium hydroxide. Preserve in well-closed containers. MATERIA MEDICA AND THERAPEUTICS 239 Properties : It occurs as a white or whitish solid in the form of bars, hard, yet easily cut when fresh, or as a fine, white or yellowish-white powder, having a faint peculiar odor, free from rancidity, and a disagreeable alkaline taste. It is soluble in water and in alcohol. Action and Uses: It is used as a pill excipient in the preparation of pills containing resinous drugs. It is used also in liniments and plasters. It is on the Supply Table under the name of Castile Soap. It originally came from Castile, Spain. Sapo Mollis, Soft Soap, U. S. P.—It is soap made by the action of sodium hydroxide and potassium hydroxide on linseed oil. Properties : It is a soft, unctuous, yellowish-white to brownish-yellow mass, having a slight characteristic odor and an alkaline taste. It is soluble in water and alcohol. Action and Uses: It is used in the preparation of liniment of soft soap (tincture of green soap). Tincture of green soap is used extensively for surgical cleansing. Linimentum Camphor® et Saponis, Camphor and Soap Liniment (Linimentum Saponis, IT. S. P. X., Soap Liniment), U. S. P.—Soap liniment is supplied to the Navy in powdered form consisting of soap, camphor, and oil of rosemary. The liniment is made from this powder by dissolving it in 70 per cent alcohol, allowing it to stand 24 hours and filtering. Action and Uses: It is applied externally with massage as a rubefacient and also is used as a vehicle in the preparation of other more active liniments (chloroform liniment). Amylaceous and mucilaginous substances. Amylaceous substances partake of the nature of starch which has the same chemical composition as cellulose (CeHioOs) and to which some of its prop- erties are closely allied. Starch is stored in plant cells in the form of granules of various shapes such as ovoid, spherical, polygonal, etc. Starches from dif- ferent plants can be recognized by the shape of their granules as seen through a microscope. Amylum, Starch (Cornstarch), U. S. P.—The starch separated from the grain of Zea Mays. Properties: It occurs in the form of a fine powder or irregular, angular, white masses, inodorous, and having a slight characteristic taste. It is insolu- ble in cold water and in alcohol. The individual grains are colored deep blue by iodine test solution. Cornstarch can be distinguished from other kinds of starch by the shape and size of the grain and the relative position of the hilum when viewed under a microscope. Boiled starch gives a dpeper blue reaction with iodine than raw starch. Action and Uses : It is used externally in dusting powders; internally as a demulcent; and in the form of starch paste in water as a vehicle for the administration of drugs by rectum. Starch paste is the best antidote for iodine poisoning. Mucilaginous substances are gums and other plant principles which in combination with water form viscid, sticky liquids. Gums have been briefly described under Gum-resins on page 234; other mucilaginous plant principles are dextrin, made from starch by oxidation with nitric acid, arabic acid, the active principle of acacia, bassorin, the chief constituent of tragacanth, cerasin, the exudation from peach and plum trees, and pectin, found in fruit juices. Dextrin is the substance which gives a loaf of bread its glossy outer surface and the high polish to- well-ironed linen. 240 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAY'S Acacia, Acacia (Gum Arabic), U. S. P.—The dried gummy exudation of Acacia Senegal and other African species of Acacia. Properties : It occurs in yellowish-white to light amber, translucent, brittle, spheroidal tears or angular fragments, inodorous, and having a mucilaginous taste. These tears or fragments are reduced to a white, granular powder and supplied under the name granular acacia. Acacia is completely soluble in water and insoluble in alcohol and very sensitive to certain reagents. It is precipitated from aqueous solutions by alcohol, tincture of ferric chloride, solution of lead subacetate, and saturated solution of borax, and should not be prescribed with these substances. Action and Uses: It is used as a demulcent and as an emulsifying agent; also as an excipient in pill making. Mucilages and syrups made with acacia do not keep well unless sterilized. Agar, Agar (Agar-agar, Chinese or Japanese Gelatin), U. S. P.—The dried mucilaginous substance extracted from Oelidium comeum and other species of Gelidium and closely related algae. It contains not more than 1 per cent of foreign organic matter, and yields not m,ore than 1 per cent of acid-insoluble ash, and not more than 18 per cent of moisture. Properties : Thin, translucent, membranous, agglutinated pieces or cut, flaked, or granulated; yellowish or brownish-white in color; brittle when dry and tough when damp; with a slight odor and a mucilaginous taste. Insoluble in cold water but slowly soluble in hot water. Action and Uses : In bacteriological work it is used in culture media. Is given internally to give moisture and bulk to the intestinal contents in chronic constipation. Average dose: 10 Gm. or 2% drams. Tragacantha, Tragacanth (Gum Tragacanth), U. S. P.—The dried gummy exudation from Astragalus gummifer or other Asiatic species of Astragalus. It is supplied in unground fragments, straight or spirally twisted ribbon-like pieces, and in ground white powder, and consists of bassorin and a soluble gum. Properties : With 50 parts of water it swells and forms a smooth, nearly uniform, stiff, opalescent mucilage. It does not dissolve in water. The best mucilage is obtained from the whole gum or flake tragacanth. Several days should be allowed for obtaining a uniform mucilage of maximum gel strength. To quickly make a mucilage from powdered tragacanth, according to “The Art of Compounding” by Scoville and Powers, it is best to first moisten the powder with a small amount of alcohol or glycerin, then add a large proportion of water, and shake and stir. In fragments tragacanth is whitish or yellowish-white in color, translucent and horny; in the powder it is white in color. It is odorless and has an insipid, mucilaginous taste. Action and Uses; It is used in the preparation of emulsions to increase consistence and retard creaming. It is used as a suspending medium in lotions, mixtures, and cosmetic preparations. It is used in the preparation of surgical lubricants. One formula for such a lubricant is: Tragacanth 12 Gm. Alcohol 10 cc. Salicylic acid 1 Gm. Boric acid 8 Gm. Sodium benzoate 2 Gm. Glycerin 45 cc. Water : 200 cc. MATERIA MEDICA AND THERAPEUTICS 241 Add the alcohol to the powdered tragacanth and stir. Dissolve the salicylic acid in the alcohol before adding it to the tragacanth. Add the glycerin. Add water containing boric acid and sodium benzoate and stir. Heat on water-bath for 1 hour. Pour into sterilized tubes while hot. Sugars and substances containing sweet principles. Included in the general classification of carbohydrates are sugars, starches, gums, and celluloses, all of which are of great importance in the life of plants and have similar chemical compositions in that they all contain C, H, and O, but in different proportions. (See p. 720.) In the chemical formulas of these substances the hydrogen and oxygen atoms attached to the carbon atoms in the molecule are present in exactly the same proportion as in water, i.e., there are always twice as many hydrogen atoms as oxygen atoms. Because of this pecu- liarity the term “carbohydrates” was given to the class of substances in which that characteristic was found. Of the substances mentioned as being classed as carbohydrates one class of sugars has the formula another the formula C0H22O11, and starches, celluloses, and constituents in gums have the formula CgHioOs. Sugars and saccharine substances having the nature of sugars are distin- guished by their sweetness of taste and their solubility in water. They are classified according to their chemical composition and their behavior toward agents such as mineral acids and enzymes which cause them to alter their composition by the addition of molecules of water and form new compounds. This forming of new compounds through the addition of molecules of water is termed hydrolysis and the agents which are instrumental in bringing about the alteration in composition are known as hydrolytic agents. Some sugars cannot be split up further by the action of hydrolytic agents and are known as monosaccharides and have the formula C.H12O0; others that split up into two molecules of monosaccharides are known as disaccharides and have the formula C12H22O11; and those that split up into three molecules of monosaccharides are known as trisaccharides and have the formula CisHaOie. Sugars which split up into more than three molecules of monosaccharides are called polysaccha- rides, in which group fall the sugars into which, because of their close chemical relationship to sugars, starches and celluloses can be converted. The polysac- charides obtained from starches and celluloses have the formula (CaHioCMn. Sugars have the ability td rotate the plane of polarized light to the right or to the left and therefore can be classified as dextrorotatory or levorotatory after the direction in which the polarized light is rotated has been determined by a polariscope or by a polarimeter. Dextrose is an example of a dextrorotatory sugar and levulose of a levorotatory sugar. Glucosum, Glucose (Syrupy Glucose, Liquid Glucose, Corn Syrup), U. S. P.—A product obtained by the incomplete hydrolysis of starch. The syrupy glucose obtained by one process of manufacture consists of 30 to 40 per cent of dextrose (d-Glucose, 30 to 40 per cent of dextrin, small amounts of other carbohydrates, notably maltose, and water. Propeeties : A colorless or yellowish, thick, syrupy liquid, odorless or nearly so, and having a sweet taste. It is very soluble in water but only sparingly soluble in alcohol. It is the principal source of Dextrose, U. S. P. The term glucose is frequently applied incorrectly to dextrose but should never be used when reference to dextrose is Intended. Action and Uses : Glucose is given per rectum as a food when feeding by stomach is impossible, and may be used to combat various types of shock. In 242 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Pharmacy it is used as a diluent in pilular extracts and has replaced glycerin in the commercial manufacture of many pharmaceutical preparations. If the U. S. P. preparation of glucose is not available ordinary commercial corn syrup is a satisfactory substitute. Glucose should not be given intravenously, intramuscularly, or intraabdom- inally as it contains substances not suitable for introduction into the body in those ways, and should not be used if dextrose is obtainable. Dextrosum, Dextrose, (d-Glucose), U. S. P.—A sugar (OelTzOu.HzO) usually obtained by the hydrolysis of starch, the conversion temperature being higher and the time of conversion longer than in the preparation of syrupy glucose. Preserve it in well-closed containers. Properties : Dextrose represents the complete hydrolysis of starch and occurs as colorless crystals, or a white, crystalline or granular powder, odorless, and having a sweet taste. It is soluble in 1 part of water and in about 59 parts of alcohol at 25° C., and is more soluble in boiling water and boiling alcohol. An aqueous solution (1 in 20) is neutral to litmus paper and is dextrorotatory. It loses not less than 8 per cent and not more than 10 per cent of its weight when dried to constant weight at 105° C. When dissolved in water and sub- jected to prolonged boiling it undergoes very little alteration. It is less sweet, less soluble in water, and more soluble in alcohol than cane sugar (sucrose). Strong mineral acids hardly act on dextrose but easily destroy cane sugar. It is sometimes called grape sugar because the principal sugar in grapes is dextrose, and has also been termed starch sugar and com sugar. Action and Uses : Dextrose is used in large quantities for its nutritive value and is usually given intravenously or injected into the subcutaneous tissues by hypodermoclysis. Dextrose is used whenever it is desired to raise the per- centage of blood sugar as in combating traumatic, postoperative, and insulin shock, in preparing feeble patients for operation, and in the treatment of threatened diabetic coma and of acidosis resulting from diabetes or starvation. When dextrose is given in diabetic conditions insulin, in the proportion of 1 unit to 5 Gm. of dextrose, is usually given subcutaneously at the same time to promote sugar metabolism. It is used extensively as a source of water supply in eases of dehydration where it is impracticable to give water by the usual methods, and in tests to determine sugar tolerance. In hypertonic solu- tions (those whose osmotic tension exceeds that of blood serum) it promotes diuresis and aids certain types of oedema. Average dose; The N. F. preparations of Dextrose are usually used when it is to be administered. The general dose of Ampullae Dextrose, Ampuls of Dex- trose, N. F., is 50 cc, containing about 25 Gm. of Dextrose; of Ampulla Dextrosi et Sodii Chloridi, Ampuls of Dextrose and Sodium Chloride, N. F., is 10 cc, containing about 2.5 Gm. of Dextrose and 1.5 Gm. of Sodium Chloride; and of Liquor Dextrosi et Sodii Chloridi, Isotonici, Isotonic Solution of Dextrose and Sodium Chloride, N. F., which contains in each 100 cc not less than 2.3 Gm. and not more than 2.5 Gm. of Anhydrous Dextrose, and not less than 0.4 Gm. and not more than 0.425 Gm. of Sodium Chloride, is 1000 cc intravenously. Sucrosum, Sucrose (Saccharum, Sugar, Cane Sugar, Beet Sugar), U. S. P.—A sugar (C12H22O11) obtained from Saccharum officinarum, Beta maritima, and other sources. Properties : It occurs in colorless or white crystals, crystalline masses or blocks, or a white crystalline powder, odorless, with a sweet taste. It is stable in the air and is Soluble in V2 part of water and 170 parts of alcohol, at 25° C., and in slightly more than %o part of boiling water. It is insoluble in chloro- form and in ether. An aqueous solution (1 in 20) is neutral to litmus paper. MATERIA MEDICA AND THERAPEUTICS 243 Sucrose is dextrorotatory but by the action of an enzyme or by heating with diluted acids is converted into the fermentable mixture called invert-sugar which is levorotatory. If a dilute aqueous solution of sucrose is exposed to warm, dust-laden air it is converted into alcohol, carbon dioxide, and eventually acetic acid. Action and Uses : Sucrose is used principally in the making of pharmaceutical preparations such as syrups, troches, masses, confections, etc. The best sugar for general pharmaceutical uses is the kind known technically as “granulated”, one of very high purity is preferable for making pharmaceutical syrups, and a finely granulated type known as “confectioner’s” or “XXXIX” sugar is es- pecially suitable for the making of troches. Sucrose has a high food value but its use should be restricted or eliminated in diabetes mellitus, in obesity, and during the existence of fermentative changes in the stomach and intestine. Glycyrrhiza, Glycyrrhiza (Licorice, Licorice Root), U. S. P.—The dried rhizome and roots of varieties of Glycyrrhiza glahra known in commerce as Spanish Licorice and Russian Licorice, and of other varieties, yielding a yellow, sweet wood. Properties : It contains the sweet principle glycyrrhizin, a salt of glycyrrhizic acid, and an oleoresinous substance which gives Glycyrrhiza its slightly acrid taste. It has a distinctive odor, a yellowish-brown, dark brown, or pale yellow color externally and a yellow or pale yellow color internally, and yields not more than 2.5 per cent of acid-insoluble ash. Action and Uses : Its value in Pharmacy is due to the sweet principle it contains. The fluidextract is on the Supply Table and is used in making Brown Mixture. Both the extract and the fluidextract of Glycyrrhiza are excellent preparations for masking the taste of bitter drugs, like quinine, but acids should not be added as they precipitate the sweet principle. Average dose: 2 cc or 30 minims of the fluidextract. Glucosides, glucosidal drugs, and preparations made from glucosidal drugs. Olucosides are organic plant principles which, when treated with diluted acids or enzymes, decompose by hydrolysis into a sugar and one or more other sub- stances. The sugar into which glucosides split is usually any one of a number of bodies having the formula of glucose, ; the other substances are usually of a complex character and in most cases are compounds of benzene. A few glucosides contain nitrogen but most are nonnitrogenous. Saponins is the name given to a group of glucosides that are readily soluble in water and produce a froth, like soap-suds, when an aqueous solution is shaken. They are good emulsifying agents and aqueous solutions of some of them are used in place of soap for cleansing purposes. Many are markedly toxic in their physiological action and will dissolve or hsemolyze red blood cells. The toxic sapouins are termed sapotoxins. Medicinally, glucosides are very active bodies, the activity in some cases being due to the glucoside itself and in others to the decompo- sition products of the glucoside. Glucosidal drugs are drugs that contain glu- cosides and it is difficult to extract and isolate the glucosides in them without having the glucosides split up into something different. Owing to the difficulty in extracting and isolating the glucosides contained in glucosidal drugs they cannot be assayed by chemical means. Biological assays (determining the strength by testing the drug on an animal) have been provided for certain glu- cosidal drugs, as digitalis, strophanthus, and squill. Glucosidal drugs are some- times grouped according to their therapeutic action as drugs containing: Sweet glucosides, bitter glucosides, glucosides acting on the heart, purgative glucosides, astringent glucosides, and saponin. 244 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Digitalis, Digitalis (Foxglove), XL S. P—The dried leaf of Digitalis purpurea. The potency of Digitalis shall be such that 0.1 Gm. of it, when assayed as di- rected, shall possess an activity equivalent to not less than 1 U. S. P. digitalis unit. One United States Pharmacopoeial Digitalis Unit is identical in potency with the International Digitalis Unit, as adopted in 1928 by the Permanent Com- mission on Biological Standardization of the Health Organization of the League of Nations. One International Digitalis Unit represents the activity of 0.1 Gm. of the “International Standard Digitalis Powder.” Digitalis contains a number of glucosides, those of the greatest importance being digitalin, digitonin, digi- talein, and digitoxin. There are many proprietary preparations of Digitalis on the market but the U. S. P. recognizes only two, Powdered Digitalis and Tincture of Digitalis. Tincture of Digitalis is on the Supply Table. The potency of Powdered Digitalis is the same as Digitalis and when Digitalis is prescribed Powdered Digitalis should be dispensed. Digitalis should he stored in water- proof and airtight containers and protected from light. Action and Uses : It is used as a cardiac tonic and stimulant, slowing and strengthening the heart beat. Digitalis is cumulative in the system. Evidence of accumulation is shown by headache, giddiness, sickness, and a marked slow- ing of the pulse. The active principles of Digitalis are irritating to the gastric mucous mebranes and may cause nausea and vomiting. In case of mild poison- ing or overdosing administer atropine sulfate hypodermically. The diuretic ef- fect of Digitalis is due to improved circulation. Average dose: 0.1 Gm. or 1% grains. Tinctura Digitalis, Tincture of Digitalis, U. S. P.—The potency of Tincture of Digitalis shall be such that 1 cc of the tincture, when assayed as directed, shall possess an activity equivalent to not less than 1 and not more than 1.1 U. S. P. Digitalis Units. It is a 10 per cent tincture, which means that 100 ce of tincture possesses the medicinal activity of 10 Gm. of the powdered drug. The alcoholic content of the tincture is 67 to 72 per cent by volume. Preserve the tincture in small, well-closed bottles, protected from light, and in a cool place. Action and Uses ; See Digitalis. Average dose: 1 cc or 15 minims. Strophanthus, Strophanthus, N. F.—The dried ripe seed of Strophanthus Komhe, or of Strophanthus hispidus, deprived of the awns. When assayed biologically as prescribed it possesses a potency, per gram, equivalent to not less than 55 milligrams of standard ouabain, U. S. P. XI. (Ouabain is a glu- coside obtained from Acokanthera Ouahaio or from Strophanthus grains that is twice as toxic as Strophanthin, and is used for the international control of Strophanthin preparations.) Strophanthus contains the active glucoside Stro- phanthin which is on the Supply Table. Action and Uses: See Strophanthin. Strophanthinum, Strophanthin, U. S. P.—A glucoside or mixture of gluco- sides obtained from Strophanthus Komhe. Strophanthin, when assayed as directed, shall possess a potency equivalent to the activity of not less than 40 per cent and not more than 60 per cent of ouabain when similarly assayed. Preserve it in well-closed containers and protected from light. Action and Uses: It is extremely poisonous. Its action is similar to the action of digitalis. It is absorbed more rapidly, its action is faster, and it is used in place of digitalis when immediate effect is required. In case of poison- ing give inhalations of chloroform to quiet the heart. If the poison is in the stomach it should be washed out. Death occurs quickly from poisoning. Average dose: 0.0006 Gm. or Mpo grain. MATERIA MEDICA AND THERAPEUTICS 245 Santoninum, Santonin, U. S. P.—The inner anhydride of santoninic acid, obtained from several species of Artemisia. Preserve it in well-closed containers, protected from light. Properties: It occurs in colorless crystals, usually tabular, or as a white, crystalline powder; odorless and nearly tasteless at first, but afterwards develop- ing a bitter taste; stable in the air, but becoming yellow on exposure to light. It is very slightly soluble in water and soluble in 43 parts of alcohol. Action and Uses : It is used principally as an anthelmintic for the removal from the intestine of Ascaris lumbricoides (round worms). It makes objects appear to the patient as if viewed through a yellow glass (xanthopsia). Average dose: 0.06 Gm, or 1 grain. (It is on the Supply Table in one- half grain tablets.) Tinctura Gentian* Composita, Compound Tincture of Gentian, U. S. P.—It contains in 1,000 cc the glycerin-hydro-alcoholic soluble principles from 100 Gm. of gentian, the active principle of which is the glucoside gentiopicrin, 40 Gm. of bitter orange peel, and 10 Gm. of cardamom seed. Action and Uses: It is used as a bitter tonic. Average dose: 4 cc or 1 fluidram. Drugs containing cathartic principles and their preparations. Fluidextractum Rhei, Fluidextract of Rhubarb, N. F.—Made by extracting the active principles of rhubarb with a menstruum consisting of 4 volumes of alcohol and 1 volume of water. Action and Uses: Acts principally on the large intestine by producing freouent fluid stools accompanied by griping. The stools frequently are col- ored yellow with bile. On account of the rheotannic acid which it contains, rhubarb constipates after its purgative action. As a laxative it is particularly efficient in treating summer diarrhoeas of children, because after its purgative effect has been produced it checks the diarrhoea. Average dose: 1 cc or 15 minims. Extractum Cascarse Sagradse, Extract of Cascara Sagrada, U. S. P.—It is an extract obtained from cascara sagrada. One grain of extract represents 3 Gm. of cascara sagrada. Cascara sagrada is the dried bark of the trunk and branches of Rhamnus Purshiana. Unlike most extracts, it is made by exhausting the drug with boiling water. Action and Uses: It is a valuable laxative, acting mainly on the lower bowel. It is used in the treatment of chronic constipation. It is supplied to the Navy in tablet form. Average dose: 0.25 Gm. or 4 grains. Fluidextractum Cascarae Sagradse Aromaticum, Aromatic Fluidextract of Cas- cara Sagrada, U. S. P.—Made by extracting the active principles of cascara sagrada with boiling water. The bitter taste is removed from the cascara by maceration and percolation while it is mixed with magnesium oxide. It is aromatized and sweetened with pure extract of glycyrrhiza, saccharin, oil of anise, oil of coriander, and methyl salicylate. It contains from 17 to 19 per cent alcohol. Action and Uses: It is preferred as a laxative over the other preparation of cascara because of its pleasant taste. Average dose; 2 cc or 30 minims. Products obtained from animal substances. Many products of great value in the prevention and treatment of disease are obtained from animals, whole animals, animal organs, animal excretions, 246 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY and animal serum being used in their production. Most of the animal products used in medicine are of such complex composition that they cannot be classed as definite chemicals; two, however, pepsin and pancreatin, are classed as ani- mal proteins, and lactic acid, obtained from milk, has a definite chemical formula. From whole animals are obtained Cantharides and Cochineal, U. S. P.; from animal organs are obtained Thyroid, Solution of Parathyroid, Thyroxin, Solu- tion of Posterior Pituitary, Epinephrine, Liver Extract, U. S. P., 'and others; from animal excretions are obtained Oxgall, U. S. P. and Milk, N. F.; and from animal serums are obtained Serums, Vaccines, Anti-toxins, Toxins, etc. Animal fats and oils have been described elsewhere but lack of space prevents the description here of all but a few of the remaining products obtained from animals and the student is referred to the U. S. Pharmacopoeia, textbooks on the Practice of Pharmacy, and other textbooks for information concerning them, Pepsimim, Pepsin, U. S. P.—A substance containing a proteolytic ferment or enzyme obtained from the glandular layer of the fresh stomach of the hog. When assayed as directed, it digests not less than 3,000 and not more than 3,500 times its weight of egg albumin. Pepsin of higher digestive power may be reduced to the official standard by admixture with pepsin of lower digestive power or with lactose (sugar of milk). Preserve it in well-closed containers in a cool place. Properties : It occurs in lustrous, transparent or translucent scales, granular or spongy masses, ranging in color from light yellowT to light brown, or as a fine, white or cream-colored amorphous powder, free from any offensive odor, and having a slightly acid or saline taste. It is not more than slightly hygro- scopic, is freely soluble in water and nearly insoluble in alcohol, in chloroform, and in ether. When in solution it is incompatible with alkalies, alkali earths, and alkali carbonates. It is destroyed by salts of copper, lead, silver, mercury, bismuth, etc. The presence of more than 0.5 per cent of hydrochloric acid in pepsin solution retards its proteolytic activity. ‘Action and Uses : Pepsin is a normal constituent of the gastric juice and its function is to digest albuminous matter. It is given when there is a defi- ciency of pepsin in the gastric juice. There are a large number of National Formulary elixirs and liquids containing pepsin. Pepsin and pancreatin never should he administered together; nor should pepsin he administered with sodium bicarbonate which renders it inert. Average dose: 0.5 Gm. or 8 grains. Liquor Pituitarii Posterioris, Solution of Posterior Pituitary (Solution of Pitui- tary), U. S. P.—It contains the water-soluble principles from the fresh posterior lobe of the pituitary body of healthy domesticated animals used for food by man. The pituitary body must have been removed from the animal imme- diately after slaughtering, and then extracted at once or kept frozen until extracted. One cc of Solution of Posterior Pituitary produces an activity upon the isolated uterus of the virgin guinea pig, corresponding to not less than 80 per cent and not more than 120 per cent of that produced by 0.005 Gm. of the Standard Powdered Posterior Pituitary. The solution must be sterile. Preserve it in small, well-filled, amber-colored containers or in ampules. Properties: A transparent liquid, colorless, or nearly so, having a faint, characteristic odor. Action and Uses; It is administered hypodermically, or intramuscularly. It stimulates smooth muscle, especially that of the blood vessels and the uterus. It increases blood pressure find is given in certain conditions of surgical shock. It is used principally to stimulate uterine contractions in labor. It is not effective when given by mouth. Average dose: 1 cc or 15 minims. MATERIA MEDICA AND THERAPEUTICS 247 Liquor Epinephrinae Hydrochloridi, Solution of Epinephrine Hydrochloride, U. S. P.—It is a solution (1-1,000) of epinephrine in distilled water and hydrochloric acid, containing, in each 100 cc, not less than 0.095 Gm. and* not more than 0.105 Gm. of epinephrine (C0H13O3N). Epinephrine is sensitive to oxidizing agents and should be bottled excluding air. Once the bottle has been opened deterioration takes place rapidly. The solution should be slightly acid, should contain a preservative to prevent the growth of germs and fungi, and should contain a reducing agent to prevent oxidation. It is commonly called adrenalin. Properties: A nearly colorless, slightly acid liquid, gradually turning dark on exposure to air and light. When the solution has become brown in color, or contains a precipitate, it must be rejected. Preserve it in small, well-filled, amber-colored bottles or in ampules. Action and Uses: It is used locally for its vaso-constrictor action in haemorrhage. The vaso-constrictor action is used to prolong the anaesthetic effect of local anaesthetics by retarding the circulation in the Injected area, thus hindering removal of the anaesthetic agent by too rapid absorption into the blood stream. In this way it also lessens the general toxic effect of the anaesthetic. Intravenous injections are given in shock and anaesthetic acci- dents. By constricting the blood vessels it causes a rise in blood pressure. It stimulates the heart. Average dose: 0.5 cc or 8 minims by parenteral injection. Extractum Hepatis, Extract of Liver (Dry Liver Extract), U. S. P.—Contains that soluble fraction of mammalian livers which increases the number of red blood cells in the blood of persons suffering from pernicious anaemia. This fraction, which has been dried, conforms to the specifications for Standardiza- tion of Products for the Treatment of Pernicious Anaemia, U. S. P. XI, approved by the “U. S. P Anti-anaemia Preparations Advisory Board.” Preserve it in well-closed containers, preferably in a cool place. Preparation : No official method of preparation is prescribed by the U. S. P. In the method of Doctors Minot and Murphy of Boston, Mass., livers of food animals are ground with water, the mixture adjusted to the isoelectric point, heated to coagulate the protein and filtered; the filtrate is evaporated in vacuo and enough alcohol added to cause a concentration of 70 per cent of ethyl alcohol. The consequent precipitate is separated, dried, and powdered. Properties ; It is a yellow powder with a not unpleasant taste, and almost completely soluble in water, but insoluble in alcohol, acetone, and ether. Action and Uses : It is used in pernicious ansemia, in sprue when the bone marrow is not exhausted, and in certain cases of obscure ansemia. Although used experimentally in other conditions only those preparations of liver pri- marily intended for the treatment of pernicious ansemia have thus far been accepted by the Council on Pharmacy and Chemistry of the American Medical Association. Liquor Hepatis, Solution of Liver, and Liquor Hepatis Purificatus, Purified Solution of Liver are also official in the U. S. P. Average dose: As indicated on the label of the container. Insulin, N. N. R.—An aqueous solution of an active principle from the pan- creas which affects sugar metabolism. The strength of Insulin is expressed in “units.” The unit is equivalent to 0.125 milligrams of the International Standard Preparation of Dry Insulin Hydrochloride prepared by the Medical Council of Great Britain. One milligram of this standard preparation contains 8 insulin units, as provisionally defined by the Insulin Commission of the University of Toronto, Canada. Action and Uses : It is used in the treatment of diabetes. If a suitable dose of Insulin is administered at suitable intervals to a person suffering from 248 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY diabetes mellitus, the blood sugar is maintained at or near a normal level and the urine remains free from sugar. In case of overdosing with Insulin the patient complains of weakness and fatigue and a feeling of nervousness and tremulousness followed by profuse sweating. This condition is relieved by giving orange juice by mouth, or dextrose intravenously if the patient is comatose. Insulin is administered by injection into the loose subcutaneous tissue of the body about 30 minutes before meals. There is no average dose for Insulin, each case must be studied individually. The dose of Insulin should always be expressed in units rather than by cubic centimeters. Alkaloids, alkaloidal salts, and alkaloidal drugs. Alkaloids are physiologically active principles found in the vegetable king- dom or produced synthetically having a complex composition. They are all nitrogenous and in addition contain carbon, hydrogen, and generally oxygen. Because they contain nitrogen, are built on the ammonia type of bases, and act as ammonias in their method of forming salts, they frequently are spoken of as nitrogenous plant bases. They are derivatives principally of pyridine, quino- line, or similar ringed bodies. The term alkaloid means “like an alkali,” with which substances, however, they must not be confused. Substances react- ing to many of the alkaloidal tests are obtained from the animal kingdom, those found in living animal tissues being generally known as leucomaines while those found in decayed animal tissues (probably produced in the process of decay) are known as ptomaines or “cadaveric alkaloids.” Alkaloids are re- garded as decomposition products of proteins, nucleins, etc., in the plant cells during the process of growth, which have condensed with the substances present in plants. In the vegetable kingdom their occurrence is confined to a few plant families as follows : Apocynacese, Leguminosse, Liliacese, Loganiacese, Papaveracese, Ranun- culaceae, Rubiacese, Rutacese, Solanacese, and Umbelliferse. They exist in all parts of plants, usually in the form of salts, as tannates, malates, quinates, meconates, etc. They can be extracted from drugs containing them, and are the active principles of the drugs in which they are present. Some alkaloids are solids (amides), and some are liquids (amines). Most of the nonvolatile alkaloids are solid, the volatile ones are mainly liquid and some of them contain no oxygen. They are generally colorless, are alkaline in their reaction, and resemble inorganic bases, especially ammonia, in their chemical behavior, in that they combine directly with acids to form salts. Their basic properties vary in intensity; some are strongly alkaline, and others are very weak. They are nearly all poisonous and have a bitter taste. With a few exceptions they are insoluble in water, but are soluble in alcohol, ether, chloroform, and petroleum benzine. The solubility of their salts is the reverse, being soluble in water but insoluble or slightly soluble in alcohol and insoluble in chloroform, ether, and petroleum benzine. Most of them are precipitated in aqueous solution from their salts upon the addition of alkalies or agents having an alkaline reaction. The alkaloids are decomposed by strong reducing or oxidizing agents (reason for the use of potassium permanganate in morphine poisoning). They are precipitated from their aqueous solution by mercuric potassium iodide, gold chloride, picric acid, tannic acid, sodium hydroxide, potassium hydroxide, alkali carbonates, alkali salicylates, benzoates, iodides, and bromides. They vary greatly in their action on the system; some are stimulants, while others are depressants, etc. Some of the most valuable remedies used in medicine, as well as most of the narcotic habit-forming drugs, belong to this class. It is important to differentiate between alkaloids, alkaloidal salts, and MATERIA MEDICA AND THERAPEUTICS 249 alkaloidal drugs. Alkaloids are the basic substances; morphine is an alkaloid. Alkaloidal salts are compounds (salts or esters) formed by the union of the basic alkaloid with an acid; morphine sulfate is an alkaloidal salt formed by the union of morphine with sulfuric acid. Alkaloidal drugs are drugs (parts of plants) containing alkaloids; opium is an alkaloidal drug because it contains, among others, the alkaloid morphine; cinchona is an alkaloidal drug because one of the alkaloids it contains is quinine. In order to distinguish alkaloids from glucosides a different terminology, which has been carried in the Pharmacopceial nomenclature, has been adopted for each class. The ending ine (Latin ina) is applied to alkaloids, and the ending in (Latin inum)) is given to glucosides. Opium, Opium, U. S. P.—The air-dried milky exudation obtained by incising the unripe capsules of Papaver somniferum or its variety album, and yielding in its normal condition not less than 9.5 per cent of anhydrous morphine. This form of opium is not used mjedicinally nor is it on the Supply Table, but it is used in making powdered opium and granulated opium, and these two preparations of opium are used in making the other opium preparations. Opium, its preparations, and its derivatives are restricted in their sale and use by the Harrison Narcotic Act, as they are habit-forming drugs. Opium Pulveratum, Powdered Opium, U. S. P.—Opium dried at a temperature not exceeding 70° C., reduced to a very fine powder, and yielding not less than 10 per cent nor more than 10.5 per cent of anhydrous morphine. Pow- dered opium of a higher morphine percentage may be brought within the required limits by admixture with powdered opium of a lower percentage, or with som,e inert diluent. Preserve it in well-closed containers. Properties: It is a yellowish-brown to brownish-red powder, having a heavy, characteristic odor and a very bitter, characteristic taste. Constituents : Opium contains more than 20 different alkaloids, the most important of which are morphine and codeine. Action and Uses : Opium and its preparations when given internally are depressant to the central nervous system, analgesic, and constipating. Opium has no local effect other than that produced after absorption. The effects produced by opium preparations are due principally to morphine. Average dose: 0.06 Gm. or 1 grain. Pulvis Ipecacuanhas et Opii, Powder of Ipecac and Opium (Dover’s Powder), U. S. P.—It is made by mixing 10 per cent opium powder, 10 per cent ipecac powder, and 80 per cent sugar of milk. Ten grains of this powder contains 1 grain of powdered opium, 1 grain of powdered ipecac, and 8 grains of milk sugar. Action and Uses : It is used as an anodyne and diaphoretic. Average dose: 0.5 Gm. or 8 grains. Tinctura Opii, Tincture of Opium (Laudanum), U. S. P.—One hundred cc of tincture of opium yields not less than 0.95 Gm. nor more than 1.05 Gm. of anhydrous morphine. It is made by extracting the active principles from granulated opium with distilled water and alcohol. Action and Uses: It is a convenient form for the administration of opium. It is used in the preparation of Lead and Opium Wash, N. F. It is given in diarrhoea for its sedative and constipating effect on the intestinal tract. It produces the characteristic effects of opium when given internally, relieving pain and producing sleep. Average dose; 0.6 cc or 10 minims. Tinctura Opii Camphorata, Camphorated Tincture of Opium (Paregoric), U. S. P.—It is made of 40 cc of Tincture of Opium, 4 cc of Oil of Anise, 4 Gm. of Benzoic Acid, and 4 Gm. of Camphor dissolved in 900 cc of diluted alcohol to 250 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY which 40 cc of glycerin and sufficient diluted alcohol are added to make the finished product measure 1,000 ce. It is the weakest and one of the most used of the opium preparations and yields, from each 100 cc, not less than 0.035 Gm. and not more than 0.045 Gm. of anhydrous morphine. Action and Uses: It possesses analgesic and carminative properties. It is one of the ingredients in Brown Mixture (checks cough). It is used to relieve abdominal pain due to flatus (gas in the intestine), to check diarrhoea, etc. Average dose: 4 cc or 1 fluidram. Morphinae Sulfas, Morphine Sulfate, U. S. P.—The sulfate of the alkaloid mor- phine. Preserve it in well-closed containers, protected from light. Properties : It occurs in white, feathery, silky crystals, or cubical masses of crystals, or a white crystalline powder, odorless, and permanent in the air. It is soluble in 15.5 parts of water and in 565 parts of alcohol. Action and Uses : It is a powerful narcotic. It is depressant to the central nervous system, relieves pain, produces sleep, and tends to cause constipation. It is a dangerous habit-forming drug and should never he prescribed in repeated doses except by a doctor. In case of acute poisoning hy morphine, wash out the stomach with potassium permanganate solution and give stimulants. Average dose: 0.008 Gm. or % grain. Codeina, Codeine (Methylmorphine), U. S. P.—An alkaloid obtained from opium, or prepared from morphine by methylation. Preserve it in well-closed containers, protected from light. Properties : It occurs in colorless crystals or as a white, crystalline powder; odorless, and is slowly efflorescent in dry air. It is soluble in 120 parts of water and 2 parts of alcohol. Its aqueous solution is alkaline to litmus. Action and Uses; It is sedative, analgesic, and hypnotic. Its action is some- what like that of morphine but less intense. It is largely used as a sedative, in the treatment of coughs, to lessen the irritation of the respiratory tract. Average dose: 0.03 Gm. or % grain. Codeinse Sulfas, Codeine Sulfate, U. S. P.—The sulfate of the alkaloid codeine. Preserve it in well-closed containers, protected from light. Properties : It occurs in colorless crystals, usually needle-like, or as a wdiite crystalline powder, efflorescent in the air. It is soluble in 30 parts of water and very slightly soluble in alcohol. Actions and Uses : Same as codeine. Average dose: 0.03 Gm. or % grain. Apomorphinse Hydrochloridum, Apomorphine Hydrochloride, U. S. P.—The hydrochloride of an alkaloid prepared from morphine. Preserve it, protected from light, in small, well-stoppered vials which previously have been rinsed with diluted hydrochloric acid and dried. Apomorphine hydrochloride, if it imparts at once an emerald-green color to 100 parts of distilled water when shaken with it in a test tube, is unfit for use. Properties : It occurs in minute, white or grayish-white, glistening crystals; odorless, and acquiring a greenish tint upon exposure to light and air. It is soluble in 50 parts of water and in 50 parts of alcohol. Action and Uses: It is an emetic and expectorant, and is devoid of narcotic properties. Its principal use is as an emetic in cases where the stomach tube cannot he passed or emetics cannot be given by mouth. It is administered hypodermically. Average dose: Emetic, hypodermically, 0.005 to 0.0065 Gm. or %2 to Vio grain. Cinchona, Cinchona (Peruvian Bark), U. S. P.—The dried bark of the stem or root of Cinchona siicciruhm, or of its hybrids, yielding not less than 5 per cent 251 MATERIA MEDICA AND THERAPEUTICS of the alkaloids of cinchona. The cinchona tree grows along the Andes Mountains in South America. Cinchona is not on the Supply Table, but it is the source of quinine, and is used in making compound tincture of cinchona. Tinctura Cinchonae Composita, Compound Tincture of Cinchona, U. S. P.— One hundred cc of compound tincture of cinchona yields not less than 0.4 Gm. nor more than 0.5 Gm. of the alkaloids of cinchona. Preparation : It is made by extracting 100 Gm. of Cinchona; 80 Gm. Bitter Orange Peel, and 20 Gm. of Serpentaria with a menstruum composed of alcohol, water, and glycerin and collecting 1,000 cc of percolate. See U. S. P. Action and Uses: It is a valuable bitter tonic and antimalarial. Average dose: 4 cc or 1 fluidram. Quininse Sulfas, Quinine Sulfate, U. S. P.—The sulfate of the alkaloid quinine. Preserve it in well-closed containers, protected from light. Properties : It occurs in white, tine, needle-like crystals, usually lusterless, making a very light and easily compressible mass; odorless and having a per- sistent, very bitter taste. It is soluble in 810 parts of water, and 120 parts of alcohol. It is freely soluble in water to which has been added a small amount of diluted hydrochloric or sulfuric acid. Action and Uses: It is antimalarial, antipyretic, and a bitter tonic. It is used principally in the treatment of malaria, for which it is specific. It should be noted that quinine sulfate is practically insoluble in water. If an aqueous solution is desired, it may be made by adding to the quinine sulfate mixed with the water in a graduate, diluted sulfuric or hydrochloric acid drop by drop until a solution is produced. An acid salt is formed in solution which is very soluble in water. Average dose: Tonic, 0.1 Gm. or 1% grains; antimalarial, at least 1 Gm. or 15 grains daily. Quininae Hydrochloridum, Quinine Hydrochloride, N. F.—The hydrochloride of the alkaloid quinine. Preserve it in well-closed containers. Properties : It occurs in white, silky, glistening needles, odorless, and having a very bitter taste. It is soluble in 16 parts of water (more soluble than the sulfate), 0.8 part of alcohol, and in 7 parts of glycerin. Action and Uses: The action and use of quinine hydrochloride is the same as the sulfate. It was added to the Supply Table for use in making Elixir of Iron, Quinine, and Strychnine, N. F., because it is more soluble than the sulfate. Average dose: Tonic, 0.1 Gm. or iy2 grains; antimalarial, 1 Gm. or 15 grains daily. Belladonnae Folium, Belladonna Leaf (Deadly Nightshade), U. S. P.—The dried leaves and tops of Atropa belladonna, yielding not less than 0.3 per cent of the total alkaloids of belladonna leaves. Belladonna leaves are not supplied to the Navy but they are used in making extract of belladonna and are the source of atropine. Belladonna leaves contain the mydriatic (pupil dilating) alkaloids of atropine, hyoscyamine, and belladonnine. Action and Uses ; See the Extract. Average dose; 0.06 Gm. or 1 grain. Extractum Belladonnae, Extract of Belladonna, U. S. P.—Extract of belladonna yields, from each 100 Gm., not less than 1.18 Gm. nor more than 1.32 Gm. of the alkaloids of belladonna leaf. It is dark green in color and of a pilular con- sistence. Extract of belladonna may be used in making tincture of belladonna. It is used in making belladonna plaster and belladonna ointment. Action and Uses: It is used internally as an anodyne and antispasmodic. In large doses it produces dryness of the throat, dilates the pupils, diminishes the secretion of urine, causes difficulty in swallowing, and checks perspiration. 154294°—39 17 252 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY It prevents griping of the intestine and is used in the compound laxative pill for this purpose. It is used locally in plasters, ointments, and suppositories for its anodyne effect. Average dose: 0.015 Gm. or % grain. Atropinse Sulfas, Atropine Sulfate, U. S. P.—The sulfate of the alkaloid atropine. Properties : It occurs as a white, crystalline powder or colorless crystals efflorescent in dry air. Great caution should he used in tasting it, and then only in very dilute solution. It is soluble in 0.4 parts of water, and 5 parts of alcohol. Action and Uses : It is used in 0.5 per cent solution to dilate the pupil of the eye. Caution : It is an extremely poisonous drug. Average dose: 0.0005 Gm. or Yi2o grain. Homatropinse Hydrobromidum, Homatropine Hydrobromide, U. S. P.—The hydrobromide of homatropine, an alkaloid obtained by the condensation of tropine and mandelic acid. Preserve it in well-closed containers, protected from light. It is an artificial alkaloid (synthetic). Properties : It occurs as a white, crystalline powder or colorless crystals. Great caution must he observed in tasting it, using only very dilute solutions. Homatropine hydrobromide is extremely poisonous. It is soluble in 6 parts of water and 40 cc of alcohol. Action and Uses : The action of homatropine is nearly identical with that of atropine. A 1 per cent solution instilled into the eye produces dilatation of the pupil in less than an hour, and the effect wears off within 48 hours. This property gives it a decided advantage over atropine, which requires a longer time to dilate the pupil and a much longer time to recover from its effect. Average dose: 0.0005 Gm. or %20 grain (seldom used internally). Hyoscyamus, Hyoscaymus (Henbane), U. S. P.—The dried leaves, with or without tops, of Hyoscyamus niger, yielding not less than 0.040 per cent of the alkaloids of hyoscyamus. Hyoscyamus is not on the Supply Table hut it is used in making the fluidextract of hyoscyamus, and it is one of the sources of scopo- lamine (hyoscine). The alkaloids contained in hyoscyamus are hyoscyamine and hyoscine (scopolamine). Action and Uses : It is related closely to belladonna in its action, but is more sedative to the nervous system (due to the hyoscine which it contains). Hyoscyamus is supplied to the Navy in the form of a fluidextract, and its active principle hyosine is supplied in hypodermic tablets under the name scopolamine hydrobromide. Average dose: 0.2 Gm. or 3 grains. Fluidextractum Hyoscayamus, Fluidextract of Hyoscyamus (Fluidextract of Henbane), N. F.—One hundred cc of fluidextract of hyoscyamus yields not less than 0.035 nor more than 0.045 Gm. of the alkaloids of hyoscyamus. Action and Uses: It is used as a hypnotic, nervous sedative, and analgesic. Given with purgatives it prevents griping effect. Average dose: 0.2 cc or 3 minims. Scopolaminae Hydrobromidum, Scopolamine Hydrobromide (Hyoscine Hydro- bromide), U. S. P.—The hydrobromide of levorotatory scopolamine, also known as hyoscine, obtained from various plants of the Solanacew. Preserve it in well-closed containers protected from the light. Properties : It occurs in colorless crystals or a white, granular powder, odor- less, slightly efflorescent. Great caution must he observed in tasting it and then only in very dilute solutions, as it is extremely poisonous. It is soluble in 1.5 parts of water and 20 parts of alcohol. 253 MATERIA MEDICA AND THERAPEUTICS Action and Uses : It is a powerful cerebral and spinal sedative and hypnotic. It is given to produce sleep, in cases of mania. Average dose: 0.0003 Gm. or V200 grain. Nux Vomica, Nux Vomica, U. S. P.—The dried ripe seed of Strychnos Nux Vomica, an Asiatic plant. The alkaloids contained in nux vomica are strych- nine and brucine. It is not on the Supply Table but is used in the preparation of tincture of nux vomica. Action and Uses : The action of nux vomica is the same as that of strychnine, which is its most active principle. It is a direct stimulant to the spinal cord, and indirectly a stimulant to nearly all the organs of the body, thereby acting as a tonic. In large doses it is a poison, producing overstimulation and convulsions. Chloroform inhalations and chloral hydrate internally are given to relieve the convulsions. Average dose: 0.1 Gm. or 1% grains. Tinctura Nucis Vomicae, Tincture of Nux Vomica, U. S. P.—One hundred cc of tincture of nux vomica yields not less than 0.108 Gm. nor more than 0.120 Gm. of strychnine. It is approximately a 10 per cent tincture, but the exact strength is based on its proximate assay. Action and Uses; It possesses the stimulating and tonic properties of nux vomica. It is used as a gastro-intestinal tonic. Average dose: 0.5 ce or 8 minims, which is equivalent to about Yl20 grain of strychnine. Strychninae Sulfas, Strychnine Sulfate, U. S. P.—The sulfate of the alkaloid strychnine. Preserve it in well-closed containers, protected from light. Pkoperties : It occurs in colorless or white crystals, or as a white crystalline powder; odorless, efflorescent in dry air, and having an intensely bitter taste. It is soluble in 35 parts of water and 81 parts of alcohol. Great caution must he used in tasting it, and then only in very dilute solutions, as it' is extremely poisonous. Action and Uses : It is a powerful stimulant directly to the spinal cord and indirectly to nearly all the organs of the body. It is a powerf ul neurotic poison, and must he administered cautiously: It is used as a respiratory and circu- latory stimulant, is used also as a bitter tonic, and frequently is combined with iron and quinine in tonics, elixirs, and tablets. Average dose: 0.002 Gm. or %o grain. Physostigminae Sulfas, Physostigmine Sulfate (Eserine Sulfate), Unofficial.— The sulfate of an alkaloid obtained from Physostigma venonosum. Preserve it in small, sealed containers, protected from light. Properties : It occurs in minute white crystals, becoming yellow on exposure to light and air. It is very deliquescent and readily soluble in water. Action and Uses : It is a myotic and is used in the treatment of eye diseases for the purpose of contracting the pupil. It is used in glaucoma to lessen intra-ocular pressure. It may be used to hasten recovery from the effects of mydriatics. For use in the eye a 2 per cent boric-acid solution should be used as the solvent. Boric acid prevents physostigmine solution from turning red in color. A red-colored solution should not be used. Average dose: 0.001 Gm. or %o grain. Pilocarpus, Pilocarpus (Jaborandi), Unofficial.—The dried leaflets of Pilocarpus Jahorandi yielding not. less than 0.6 per cent of the alkaloids of Pilocarpus. It contains a number of alkaloids, the most important of which is pilocarpine. Pilocarpine hydrochloride is on the Supply Table in the form of 0.008 Gm. or Ys grain hypodermic tablets. 254 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY Pilocarpinse Hydrochloridum, Pilocarpine Hydrochloride, N. F.—The hydro- chloride of an alkaloid obtained from the dried leaflets of Pilocarpus Jaborandi. Preserve it in well-closed containers protected from light. Properties: It occurs in colorless, translucent crystals, odorless, and having a faintly bitter taste; hygroscopic on exposure to the air. It is soluble in 0.3 parts of water. Action and Uses : It is used as a diaphoretic. In diseases of the eye such as glaucoma and corneal ulcer pilocarpine is used locally in weak solution to contract the pupil of the eye and thereby reduce intra-ocular pressure. Average dose: 0.005 Gm. or y12 grain (hypodermically). Aconitum, Aconite (Monkshood), U. S. P.—The dried tuberous root of Aconi- tum Napellus and its subspecies and varieties containing aconitine, a very active and poisonous alkaloid. Aconite is not on the Supply Table but is used in making tincture of aconite. Tincture Aconiti, Tincture of Aconite, U. S. P.—It is approximately a 10 per cent tincture. Tincture of Aconite possesses a potency, per cubic centimeter, equivalent to not less than 0.140 milligram and not more than 0.160 milligram of the alkaloid aconitine. Action and Uses : Aconite slows the pulse and lowers the blood pressure It is used internally as a circulatory depressant, diaphoretic, and antipyretic in fevers of short duration. It is a very poisonous tincture and must be administered cautiously. Average dose: 0.6 cc or 10 minims. Ipecacuanha, Ipecac, U. S. P.—The dried rhizome and roots of Cephaelis ipecacuanha or of Cephaelis acuminata, yielding not less than 2 per cent of the ether-soluble alkaloids of ipecac. Ipecac contains several alkaloids, the most important of which is emetine. Action and Uses : In large doses it acts as an emetic partly through its local irritant action. In small doses it stimulates the secretions of the respira- tory tract. It is specific against amoebic dysentery, given in the form of enteric pills. Average dose: Expectorant, 0.06 Gm. or 1 grain; emetic, 1 Gm. or 15 grains. Fluidextractum Ipecacuanhse, Fluidextract of Ipecac, U. S. P.—One hundred cc of fluidextract of ipecac yields not less than 1.8 Gm, nor more than 2.2 Gm. of the ether-soluble alkaloids of ipecac. Action and Use; The action and use of the fluidextract is the same as that of powdered ipecac. The principal use of the fluidextract is in making the syrup of ipecac. Average dose: Expectorant, 0.05 cc or 1 minim; emetic, 1 cc or 15 minims. Emetinse Hydrochloridum, Emetine Hydrochloride, U. S. P.—The hydrochloride of an alkaloid obtained from ipecac or prepared synthetically. It contains variable amounts of water of crystallization. Preserve it in well-closed con- tainers protected from light. Properties : It occurs as a white crystalline powder, without odor, and freely soluble in water. Action and Uses : It is used in the treatment of pyorrhoea and amoebic dysentery, administered hypodermically. Average dose: 0.02 Gm. or y3 grain. Coca, Coca, Unofficial.—The dried leaves of Erythroxylon Coca, known com- mercially as Huamico Coca, or as Truxillo Coca, yielding not less than 0.5 per cent of the ether-soluble alkaloids of coca. It is cultivated in South America, Mexico, and the West Indies. Most of the coca leaves come from Peru, Bolivia, and Ecuador. It contains a number of alkaloids, the most important of which 255 MATERIA MEDICA AND THERAPEUTICS is cocaine. Coca leaves, its preparations, and derivatives, which includes cocaine, are restricted in their sale and use hy the Harrison Narcotic Act. Coca leaves are not on the Supply Table nor are they recognized by the Phar- macopoeia or National Formulary, and are of interest only as the source of cocaine. Cocainse Hydrochloridum, Cocaine Hydrochloride, U. S. P.—The hydrochloride of thfe alkaloid cocaine, obtained from Coca leaves. Properties : It occurs in colorless crystals or as a white, crystalline powder; soluble in 0.4 cc of water; soluble in glycerin and slightly so in alcohol. Cocaine solutions are decomposed by the heat of boiling water or in the presence of even slight traces of alkali. Action and Uses : When applied locally, cocaine paralyzes the peripheral nerves, causing loss of sensation. When injected around a nerve sheath or into a nerve it produces anaesthesia in the area supplied by the sensory fibers, of that nerve. When absorbed into the system it first produces stimulation, fol- lowed by depression of the central nervous system. The principal use of cocaine is as a local anaesthetic. It can be used for deadening sensation in the eye when foreign bodies are to be removed. It is employed in solutions ranging from 1 to 5 per cent, made with distilled wrater. The absorption of cocaine is largely prevented by mixing 1 part of solution of epinephrine hydro- chloride with 20 parts of cocaine solution. Cocaine is a dangerous habit-form- ing drug and must be used cautiously to avoid starting the habit. Average dose: 0.015 Gm. or grain. Ergota, Ergot (Ergot of Rye), U. S. P.—The dried sclerotium of Claviceps purpurea developed on rye plants. It contains not more than 8 per cent of moisture and not more than 4 per cent of seeds, fruits, and other foreign organic matter. Ergot is not on the Supply Table but is used in making the Fluidextract of Ergot. Fluidextractum Ergotae, Fluidextract of Ergot, U. S. P. Action and Uses: It is a powerful vascoconstrictor. It is used in the latter stages of labor as a stimulant to the uterus and a preventive of luemorrhage. Is also used to control other internal haemorrhages and for the relief of chronic congestions. Owing to its effect on the circulation it is also employed in many other diseases. Average dose: 2 ce or 30 minims. Caffeina Citrata, Citrated Caffeine, U. S. P.—A mixture of caffeine and citric acid containing, when dried to constant weight at 80° C., not less than 48 per cent and not more than 52 per cent of andydrous caffeine (CsHioChNU. Properties : It occurs as a white powder, odorless and having a slightly bitter, acid taste. It is soluble in about 4 cc of water. On diluting this solution with an equal volume of water caffeine slowly separates but redissolves on the further addition of water. Action and Uses ; It is used as a cerebral and cardiac stimulant and as a diuretic. Average dose: 0.3 Gm. or 5 grains. Caffeina cum Sodii Benzoate, Caffeine with Sodium Benzoate, U. S. P.—A mix- ture of caffeine and sodium benzo'ate, containing, when dried to constant weight at 80° C., not less than 47 per cent and not more than 50 per cent of anhydrous caffeine (CsHioChN*) ; and not less than 50 per cent and not more than 53 per cent of sodium benzoate (NaCTphCh). Preserve it in well-closed containers. Properties : It occurs as a white powder, is odorless, and has a slightly bitter taste. It is soluble in 1.1 parts of water. 256 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Action and Uses: It is used for the same purposes as citrated caffeine. It is preferred to caffeine citrate for hypodermic administration because it is more soluble in water. Average dose: 0.2 Gm. or 3 grains (hypodermically). Ephedrina, Ephedrine, U. S. P.—An alkaloid obtained from Ephedra cquisetina, Ephedra sinica and other species of Ephedra. It was first obtained from a Chinese herb. It is closely related to epinephrine structurally but is more stable. Properties : An unctuous, almost colorless solid, or white to colorless crystals or granules. It is soluble in water, in alcohol, in chloroform, in ether, and in liquid petrolatum, the latter being turbid if the ephedrine is not dry. Solu- tions of ephedrine are’strongly alkaline to moistened red litmus paper. Action and Uses : Ephedrine produces effects similar to those produced by epinephrine (adrenalin). It increases blood pressure and causes dilation of the bronchi and of the pupils of the eyes. It is used for shrinking congested nasal mucous membranes in rhinitis and sinusitis. It is also given in the treatment of asthma and hay fever. It may be given by mouth, hypodermically, or intramuscularly. The base (ephedrine) is used in ephedrine oil inhalant (usually 1 to 3 per cent in liquid petrolatum). The hydrochloride and sulfate are used in water solution. The sulfate is used in ephedrine jelly and in ephedrine syrup. The salts are not soluble in liquid petrolatum and cannot be used in the preparation of the oil inhalants. Average dose: 0.025 Gm. or % grain. Procainse Hydrochloridum, Procaine Hydrochloride (Procaine), U. S. P.— Para-aminobenzoyl-diethylaminoethanol hydrochloride (C13H20O2N2.HCI). Properties : It occurs as small, colorless crystals, or a white, crystalline powder, is odorless, stable in the air, and soluble in 0.6 parts of water and 30 parts of alcohol at 25° C. It is precipitated from its aqueous solutions by alkali hydroxides and carbonates but not by sodium bicarbonate. An aqueous solution (1 in 20) is neutral to litmus paper. The aqueous solution may be heated to boiling without decomposition occurring which is a decided advantage over cocaine in that procaine may be thoroughly sterilized. Action and Uses : It is a local anaesthetic similar in action to cocaine but less toxic than cocaine and most other cocaine substitutes. When injected subcutaneously it exerts a prompt and powerful anaesthetic action, but the effect is not sustained. This condition is remedied by the simultaneous injection of epinephrine. It is nonirritant and has very little anaesthetic effect when applied externally to mucous membranes. Average dose; In place of the usual average dose the following information is given; For infiltration anaesthesia, 0.25 Gm. or 4 grains in 100 or 50 cc of physiological salt solution, making a or a % per cent solution, with 5 or 10 minims of epinephrine solution (1 in 1,000) is used; for instillations and injections, 0.1 Gm. or 1% grains in 10 or 5 cc of physiological salt solution, making a 1 or a 2 per cent solution, with or without 10 minims of epinephrine solution (1 in 1,000) is used; in ophthalmology 1 to 5 or even up to 10 per cent solutions are used; and in rhinolaryngology 5 to 20 per cent solutions with 6 to 8 minims of epinephrine solution (1 in 1,000) to each 10 cc of solution are used. Internally, owing to its feeble toxicity, 0.5 Gm. or 8 grains may be given. Barbital and related compounds. Barbital, or diethylbarbituric acid, was introduced under the name “veronal” and is chemically related to urea, or carbamide (the diamide of carbonic acid), and the hypnotic compounds derived from urea. TOXICOLOGY 257 Barbitalum, Barbital (Diethylbarbituric Acid), U. S. P. Properties : Colorless or white crystals, or a white crystalline powder, odor- less, with a slightly bitter taste, and stable in the air. It is soluble in 130 parts of water, and in 14 parts of alcohol. A saturated solution in water is acid to litmus paper. Action and Uses ; It induces sleep and is a relatively safe hypnotic. A large number of deaths have resulted from its use, due to a single overdose or continuous administrations of small doses. Average dose: 0.3 Gm. or 5 grains. Phenobarbitalum, Phenobarbital (Luminal), U. S. P.—This compound is closely related chemically to barbital in that it represents barbital with an ethyl group replaced by a phenyl group. Properties : White, glistening, small crystals or a white crystalline powder, odorless, and stable in the air. It is soluble in 1,000 parts of water, and in 8 parts of alcohol. A saturated aqueous solution is acid to litmus paper. Action and Uses: It is used as a sedative and hypnotic. The action is sim- ilar to that of barbital but more powerful. It is poisonous in large doses. Average dose: 0.03 Gm. or % grain. References United States Pharmacopoeia. National Formulary.—American Pharmaceutical Association. New and Non-Official Remedies.—American Medical Association. Useful Drugs.—American Medical Association. United States Dispensatory.—Wood-LaWall. Principles of Pharmacy.—Arny-Fischelis. Inorganic Pharmaceutical Chemistry.—Rogers. Pharmaceutical Recipe Book.—American Pharmaceutical Assoc. Remington’s Practice of Pharmacy.—Cook-LaWall. A Textbook of Practical Therapeutics.—Hare. Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. Section 2.—TOXICOLOGY Toxicology is the science which treats of poisons. It is concerned with the detection, isolation, and quantitative estimation of poisons, their chemical and physiological effect on the ordinarily healthy organism, and the antidotes to their toxic effects. A poison is a substance which may produce death, serious illness, or harmful effects when introduced into the body. The effects of poisons may be local or remote and some poisons have both a local and a remote effect. By local effect is meant direct action on the part to which the poison is applied, such as corrosion and irritation, and by remote effect is meant the action of the poison on some organ remote from the seat of application or point of introduction. Sometimes a poison shows no effect, or only a slight one, until several doses have been taken, when suddenly an effect is produced nearly equal to that to be expected if the whole amount in the several doses had been taken at once. This is known as cumulative effect. The effect of a poison depends upon its solubility, the method of its introduction into the body, and the rapidity of its absorption into the system, and the method of introduction may determine its toxicity. For example, snake venom taken into the mouth and perhaps even into the stomach during first-aid treatment of a snake bite is not ordinarily harmful, but if snake venom were injected hypodermically it might be extremely poisonous. 258 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY There are various ways in which poisons may be introduced into the body, the most common being by mouth, by inhalation, and by injection. Poisons taken by mouth enter the circulation through absorption from the stomach and intestine and those inhaled enter the circulation through the air passages and lungs. When introduced by hypodermic injection or by injection into the ure- thral, rectal, or vaginal orifices poisons enter the circulation through absorp- tion from the body tissues and if the injection is intravenous they are in- troduced directly into the blood stream. Poisons may also be introduced through application to open wounds and to the unbroken skin. After entering the circulation a poison is carried by the blood to the tissues, and organs susceptible to its action and attacks them. Most of the excretion of poisons from the body takes place in the kidneys, lungs, liver, gastrointestinal tract, skin and salivary glands, and they may be excreted from the system unchanged or in the form of other compounds into which they have been transformed by the action of the various body organs and tissues. The most damaging effects of some poisons are found at the points of excretion, as in the kidneys and colon in poisoning by mercuric chloride (bichloride of mercury). Various conditions of the individual may modify the action and effect of poisons on the body. The age of the person makes a great deal of difference, young children being much more susceptible to poisons than adults and younger persons more so than older ones. Personal idiosyncrasy has a marked influence on the action of poisons, some persons by nature being unusually sensitive to certain poisons while others possess a natural tolerance for certain poisons that is not the result of habitual use. Most persons through habitual use of certain poisons, especially the narcotics, may become so accustomed to their effects that because of the habit they are not poisoned when they take doses of those poisons that ordinarily would produce death. It occasion- ally happens, however, that instead of becoming inured to their action the continuous use of chemical poisons externally results in a condition of hyper- sensitiveness. The action of poisons may be considerably modified by disease, some diseases increasing and others lessening the action of poisons, and in the latter case large doses are usually required to produce the desired effect. Poisoning may be either acute or chronic. Acute poisoning is the condition brought on by the individual taking one overdose of poison. Chronic poisoning is the condition brought on by the individual taking repeated doses of a poison or as the result of the absorption of the poison over a long period of time. Matchmakers, barometer and thermometer makers, painters, and wall paperers are some of the classes of people subject to chronic poisoning from phosphorus, mercury, lead, and arsenic, respectively. Poisons may be scientifically classified as follows; 1. Gaseous poisons: Poisons present in the gaseous state which, if inhaled, destroy the capability of the blood as a carrier of oxygen and irritate or destroy the tissues of the air passages and the lungs, and when in contact with the skin and mucous membranes produce lacrimation, vesication, in- flammation, and congestion. Examples: Carbon monoxide, carbon dioxide, hydrogen sulfide (“sewer gas”), sulfur dioxide, nitrous oxide (“laughing gas”), nitric oxide and nitrogen dioxide, ammonia gas, chlorine, bromine vapors, “war” gases, etc. 2. Inorganic poisons: (a) Corrosives. Substances which rapidly destroy or decompose the body tissues at point of contact. Examples: Hydrochloric, nitric, and sulfuric acids in concentrated form, oxalic acid, glacial acetic acid, 259 TOXICOLOGY phenol, potassium hydroxide, sodium hydroxide, iodine, etc. (&) Metals and their salts. Substances which are corrosive and irritant locally but whose chief action occurs after absorption and damages internal organs, especially those of excretion. Examples: Arsenic, antimony, 'bismuth, copper, iron, lead, mercury, radio-active substances, tin, etc. 3. Alkaloidal poisons: Nitrogenous plant principles which produce their chief effect on some part of the central nervous system. Examples: Aconitine, atropine, cocaine, morphine, physostigmine (eserine), strychnine, etc. 4. Nonalkaloidal poisons: Various chemical compounds, some obtained from plants, having hypnotic, neurotic, irritant, and systemic effects. Examples : Barbital, salicylic acid, trinitrotoluene, acetophenetidin, digitalis, strophanthus, castor oil, croton oil, oleoresin of male fern, turpentine, santonin, canthar- ides, etc. 5. Food poisons: These may be poisonous metallic or organic substances intro- duced by carelessness, accident, or intention into wholesome food; poisonous substances naturally present in the vegetable or animal tissues used as food; pathogenic bacteria in the food, or poisonous substances produced in food by the changes resulting from the action of bacteria. Examples of each of the above classes are: Arsenic, lead, tin, zinc, and copper introduced from containers, soldering, chemical action, and for purposes of adulteration; the poisons found in mushrooms, sometimes in rhubarb, and roots and tubers ordinarily edible, cer- tain species of fish and the flesh and roe of some fish during the spawning sea- son ; the causative agents of diphtheria, tuberculosis, scarlet fever, and typhoid fever in milk, of typhoid fever in or upon bread, sausage, oysters, and other foods, of botulism in or upon uncooked sausages, ripe olives, and other fruits and vegetables, and the ingestion of meat containing encysted worms or the larvae of worms; and the poisons, commonly known as ptomaines, which result from the decay or decomposition of food substances. For convenience of study the following general classification of poisons accord- ing to their chief effects on the body will be used: Coeeosives.—Substances which rapidly destroy or decompose the body tissues at point of contact. Examples: Hydrochloric, nitric, and sulfuric acids in concentrated form, oxalic acid, glacial acetic acid, phenol, potassium hydroxide, sodium hydroxide, iodine, etc. Iebitants.—Agents that do not directly destroy the body tissues but set up an Inflammatory process at the site of application or contact. Examples: Potas- sium nitrate, zinc chloride, zinc sulfate, ferrous sulfate, silver nitrate, arsenic, iodine, phosphorus, etc. Neueotics.—Poisons which act on the brain, spinal cord, and the general nerv- ous system. Examples: Opium, hydrocyanic acid (prussic acid), ether, chloro- form, aconite, nux vomica, belladonna, ethyl and methyl alcohol, etc. The general symptoms of poisoning by poisons of any of these classes are given next, and, in addition, the symptoms of individual poisons will appear in the table describing those poisons. Coeeosives.—Immediately there is an acid, caustic, burning pain in the mouth, with severe burning pain in the oesophagus and stomach. • This is followed by retching and vomiting of the stomach contents mixed with dark-colored liquid and shreds of mucous membrane from the mouth, oesophagus, and stomach; the inside of the mouth is corroded and the lips present the characteristic stain if an acid has been used. Swallowing is very difficult; respiration is impeded; the abdomen is tender and distended with gas; the temperature is high; and the countenance is expressive of anxiety and great suffering. 260 HANDBOOK OE THE HOSPITAL CORPS, U. S. NAVY Irritants.—Nausea, vomiting, and purging (frequently the vomited matter and stools contain blood) ; pain and cramps in the abdomen. In some cases there is inflammation of the urinary tract. Neurotics.—-As it is a difficult matter to give general symptoms of this class of poisons, they are here classified under— (a) Depressants, which are characterized by a period of exhilaration fol- lowed by drowsiness and stupor; slow and stertorous breathing; cold, clammy skin; livid countenance, slow pulse, muscular relaxation; dilated or contracted pupils, insensibility to external impressions, and (&) Excitants, characterized by rapid and feeble pulse; delirium; hot and dry skin; a sense of suffocation and inability to breathe; shuddering, and jerking of muscles; dilated or contracted pupils; disordered vision; sometimes convulsions and tetanus (as in the case of strychnine poisoning). Gaseous poisons.—Irritation and corrosion of the respiratory tract, with resultant bronchitis (either mild or severe) ; irritation of the eyes, mouth, stomach, and kidneys. Food poisons.—Gastrointestinal distress, nausea, vomiting, diarrhoea, urticaria, circulatory and nervous disturbances are the general symptoms of food poison- ing and they may vary from mild discomfort to violent disturbance of the normal body functions. The treatment of poisoning consists of: 1. Removal of the poisonous sub- stance from the stomach; 2. Administration of antidotes; 3. Elimination of the poison from the circulation; and 4. Neutralization of the systemic effects of the poison. Only the first two parts of the treatment will be discussed here, the other two being particularly within the province of the medical officer. Removal of the poison from the stomach may be accomplished by the use of emetics (agents used to produce vomiting) and washing out of the stomach with a stomach tube. There are two kinds of emetics: (a) Local, which act by irritating the ends of the gastric, oesophageal, and pharyngeal nerves; and (b) Systemic, which act on the vomiting center in the medulla through the medium of the circulation. Commonly used emetics are powdered ipecac, 30 grains; ground mustard, 2% drams; tartar emetic, % to 1 grain; zinc sulfate, 10 to 20 grains; copper sulfate, 5 to 7% grains; fluidextract of ipecac, 15 to 30 minims; tepid water, large quantity; alum, 60 grains to 8 fluidounces of water; use of index finger; apomorphine hydrochloride (hypodermically), %5 to % grain. Antidotes are agents which counteract the effects of a poison, and are classi- fied as: (a) Chemical antidotes, which combine directly with the poisons and render them inert or harmless or produce a more insoluble compound and thus delay the absorption of poisons; and (b) Physiological antidotes, which coun- teract the effect of poisons on the system. Substances preventing absorption of poisons by holding them in suspension or by coating the stomach are con- sidered as a third class and are known as mechanical antidotes. The primary purpose of treatment in a case of poisoning is to prolong the life of the individual if possible. With that objective ever in mind the duties of a person attending a case of poisoning are: 1. To quickly get the bulk of the poison out of the stomach; 2. To antidote the remainder of the poison left in the stomach; 3. To eliminate from the system that portion of the poison which has been absorbed; 4. To treat the symptoms as they arise; and 5. To take possession of all foods, medicines, vomited matter, faeces, urine, and anything that may be of value in determining whether the poison was TOXICOLOGY 261 taken accidentally or intentionally, or whether criminally administered. The nature or identity of the poison may have to be determined from such things and in cases of food poisoning it is most important to collect them. Cases of poisoning frequently are met with when it is almost impossible to obtain much or any information relative to the nature or type of poison taken. Any delay in treatment may result in serious consequences. Therefore every hospital corpsman should possess some practical knowledge of how to manage a poisoning case when the nature of the poison is unknown. For the purpose of general treatment in unknown poisons, the case may be considered as one of two kinds; it may be either a case where the local effects of the poison have injured the mucous lining of the mouth, oesophagus, and stomach to an extent contraindicating the use of instruments or emetics for evacuating the stomach; or, it may be a case where the poison has had but little or no local effect on the mucous lining of the alimentary tract, and there- fore one in which it would be safe to use a stomach tube or an emetic. Poisons coming under the classification of “Corrosives” generally produce conditions such as mentioned in the first Instance. They have a more or less injurious and even destructive effect on the lining of the mouth and stomach, and naturally in such cases the introduction of any sort of instrument, even a soft rubber stomach tube, may result in a perforation in the weakened wall; in such conditions, even rupture of the stomach may be caused by emesis. Poisons classified under “Irritants” and “Neurotics” have, generally, no special local or injurious action on the mucous membrane of the mouth and stomach, and therefore in such cases the stomach may be evacuated and washed by the aid of a stomach tube, or in the absence of a stomach tube the use of emetics could be resorted to without fear of injury. Even when the exact nature of the poison is unknown, one seldom finds it difficult to determine whether the offensive material belongs under the classi- fication of “Corrosives” or not; a corrosive leaves unmistakable signs about the lips and mouth. When the local condition points to a corrosive poison, the evidence usually Indicates also whether it is of the acid or alkali type. In the case of an acid, the general treatment is the same as that outlined under “Hydrochloric acid,” while the general treatment for almost any strong alkali is outlined under “Caustic alkali.” In neither case are the stomach tube or emetics employed. In cases where there are no signs of injury to the lining of the mouth, the probabilities are that the poison is one of the so-called “Irritants” or “Neu- rotics” ; that is, the poison may be a salt of one of the poisonous metals, as arsenic, mercury, copper, tin, zinc, silver; or it may be one of the alkaloidal drugs of opium, belladonna, nux vomica, or perhaps one of the many alkaloids, among the more common of which may be mentioned morphine, codeine, co- caine, heroin, atropine, and strychnine, although in an unknown case it would hardly be strychnine, for the symptoms in a case of strychnine poisoning are very characteristic. The patient may be suffering from poisoning by one of the drugs known as glucosides, of which the active principles of digitalis are ex- amples; or, the case may be one of poisoning by grain alcohol, wood alcohol, chloral, a cyanide, phosphorus, iodine (leaves stains on lips), or phenol (the undiluted form has corrosive action). Almost the entire range of possibilities for poisons coming under either the classification of “Irritants” or “Neurotics,” may be treated with a general antidote having properties of precipitating them, or of physically or chemically combining with those poisons in a manner to reduce their toxicity and, in some instances, to convert them into altogether harmless compounds. The following 262 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY is considered an excellent general antidote; Take one tablespoonful of mag- nesium oxide, 1 tablespoonful of tannin (tannic acid), 3 tablespoonfuls of powdered charcoal, and a small amount of water and mix together into a paste, thin the paste by further addition of water, about half filling an ordinary glass tumbler. This general antidote is administered in doses of from 1 to 2 ounces each. Wash the stomach with lukewarm water or saline solution be- tween doses of the antidote, which should be repeated at intervals of 10 minutes so long as may appear necessary. Occasionally, after washing out the stomach and between doses of antidote, give the patient a thin paste of starch, the white of two eggs or other albuminous substance. Always use the stomach tube when possible under the circumstances; the stomach tube facilitates the administration of antidotes as well as the washing out of the stomach at short and frequent intervals, and permits the handling of the case in a positive manner, in so far as it places under control the admin- istration of emergency treatment. When the stomach tube is not used, the patient is ’required to assist and work on himself; he must swallow large vol- umes of antidotal mixtures, saline solution, warm water, and besides he must take emetics to promote vomiting. All such efforts on the part of the patient have a tendency to weaken him and thereby lower his general resistance. However, when for any reason the stomach tube is not employed, antidotes must be taken by mouth and removed by emesis, which may in some cases be brought on by the tickling of the fauces but more often requires the use of emetics, the following being a very effective one and very easily prepared: About 2 teaspoonfuls of mustard in a glass of warm water. Soapy water is an excellent emetic, made by dissolving castile soap in water, this also has antidotal action on a number of metallic salts, principally mercuric chloride. Two teaspoonfuls of table salt dissolved in a glass full of warm water is some- times used as an emetic with good effect. After removing the residual poison from the stomach by the use of the stomach tube or emetics, magnesium sulfate should be given in small doses until a total of about 1% ounces has been taken. No oils should be given unless it is certain that the patient is not suffering from an oil-soluble poison such as phosphorus or phenol. This outline relative to the management of poison cases when the nature of the poison is not known covers only those steps that have to do with the removal of unabsorbed portions of poison, the residual poison, from the stomach, but the hospital corpsman should not lose sight of the fact that the treatment also calls for the application of proper measures to counteract that portion of the poison that may have been absorbed and carried in the system of circulation. No definite outline of treatment can be laid down for combat- ing the possibilities which may arise from absorbed poisons; this part of the treatment is based entirely on the symptoms the case presents. Effort to hasten the elimination of absorbed poison would include the giving of large quantities of water, the use of hot packs to stimulate skin action, and probably the use of enemas if deemed advisable under the circumstances. The hospital corpsman should endeavor to alleviate symptoms and distress of the patient by such means as come within his knowledge and experience in the general care of the sick, using hot water bags, ice bags, etc., as indicated. Physiological antagonists should not be administered in the absence of definite information as to the nature of the poison ingested. Medication should be limited to drugs whose physiological action is clearly understood by the hospi- tal corpsman. 263 TOXICOLOGY Symptoms ■ Suspect poisoning by— Poison suddenly fatal Hydrocyanic acid; potassium cyanide; phenol; oxalic acid; poisonous gases. Corrosive acids or alkalies; arsenic; antimony. Strychnine. Alcohol; opium (preparations); chloral hydrate; carbon monoxide or dioxide. Alcohol; atropine; belladonna; hyoscyamus; cannabis indica; camphor. Opiates (chronic); cocaine (chronic). Belladonna; gelsemium. Methyl (wood) alcohol. Quinine; salicylic acid, chenopodium. Mercurials; aconite; pilocarpine. Atropine; homatropine; gelsemium; hyoscyamus. Opium (preparations); phenol; pilocarpine; physostigmine Opiates; aconite; pilocarpine; salicylic acid and salicylates. Atropine; cocaine; scopolamine. Carbon dioxide; coal-tar products. Mercury; lead; arsenic. Phosphorus; potassium chlorate or nitrate. Bromides or iodides internally; croton oil, poison oak or ivy externally. Aconite; beginning lead palsy. Corrosive acids; alkalies; phenol; bichloride of mercury. Nitric acid (changing to brown). Iodine; bromine; potassium permanganate. Copper salts; Paris green. Arsenic; antimony; mercuric salts; ptomaines. Apomorphine; aconite. Lead; opiates. Opiates; digitalis (at first); physostigmine. Atropine; hyoscyamus; cocaine. Aconice; digitalis; physostigmine; salicylic acid; carbon dioxide. Lead; mercury; alcohol. Santonin; picric acid. Sulfonal; trional. Phenol; tar; creosote. Oxalic acid; atropine; potassium chlorate or nitrate. Mineral acids; oxalic acid. Turpentine; copaiba; cubeb. Collapse, with cold clammy skin and rapid pulse. Coma Active delirium M ental hebetude ... Double vision _ .. _ _ Blindness. .. Ringing in the ears Salivation (ptyalism) Pupils— Dilated _ . Contracted ... Skin— Moist, Hot and dry Dark but not cyanotic Yellow _ Eruptions Numbness and tingling Discoloration of tongue and mem- branes of mouth and throat— White Yellow Brown-. Greenish blue Vomiting and purging. __ _ Pulse— Muscular tremors Urine- Yellow - .. Symptoms of Poisoning by Certain Poisons Aconite. (Neurotic.) TABLE OE POISONS, SYMPTOMS AND TREATMENT. Symptoms : Palor; salivation; tingling and numbness in mouth and fingers; burning in throat and stomach; nausea and vomiting; slow, feeble and irregular pulse; rapid and shallow respiration; muscular weakness; cold, clammy skin; difficult swallowing; impaired voice; cramps in extremities and possible tetanic convulsions; death from paralysis of the heart and of respiration. Treatment: Place patient on back with head lower than feet; give animal charcoal (1 tablespoonful), tannic acid (10 to 30 grains), tea or strong coffee, as a chemical antidote. Apply heat externally; use stomach tube or siphon of rubber tubing to empty stomach (avoid emetics); administer stimulants, as aromatic spirit of ammonia, caffeine, atropine, ether, strychnine, and amyl nitrite. Physiological antagonist is digitalis. Artificial respiration if breath- ing stops. 264 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Alcohol, ethyl. (Neurotic.) Symptoms : Exhilaration, staggering gait, deep sleep with stertorous breath- ing, acute gastritis and profound depression. Delirium tremens frequently occurs after an alcoholic debauch. Treatment: Emetics or the use of the lavage tube, purgatives, proper diet, external heat. Ammonia inhalations, atropine, caffeine, digitalis, strychnine, oxygen, artificial respiration. The morbid conditions with which acute alcoholism may be confounded are: Apoplexy, opium narcosis, concussion of the brain, uraemia, epilepsy, and even acute pneumonia. The differential diagnosis is difficult to make in a state of deep coma. The pupils in alcoholism may be either dilated or contracted. Alcohol, methyl. (Neurotic.) Symptoms: Primary, dizziness, headache, nausea and vomiting, dimness of vision, with befogging of the brain; later, widely dilated pupils with ultimate blindness, weakened circulation, stupor, coma, delirium, convulsions, cold clammy skin, subnormal temperature, death from paralysis of respiratory center. Treatment ; Immediate evacuation of the stomach by means of a stomach tube followed by washing the stomach with a very dilute potassium perman- ganate solution, then warm water; administer two or three ounces of a solution of magnesium sulfate (Epsom salt) before removing the stomach tube; administer stimulants; apply external heat. It is beneficial at times to do a venesection; remove a quantity of blood and administer physiological saline solution intraveneously. (This should be done by medical officers only). Stupor from wood alcohol poisoning is treated by introducing into the system large doses of sodium, bicarbonate and sodium citrate solutions, either by mouth or by rectum. Arsenic. (Irritant.) Present in Fowler’s solution, Paris green, rat poisons. Symptoms : Faintness and depression come on in about one-half hour; intense pain in the region of the stomach; tenderness of abdomen on slight pressure, nausea and vomiting increase by every act of swallowing; purging, bloody stools; cold, clammy skin; feeble pulse. Treatment: Emetics (one of mustard, 1 part, salt, 6 parts, in large amount of water may be used) ; wash out stomach with warm water and milk. Then give a wineglassful of freshly prepared Magma of Ferric Hydroxide. Reliance must be placed on copious gastric lavage frequently repeated as the poison is not freely soluble. Warmth externally and demulcent drinks. Give opium, atropine, strychnine, and spirit of nitrous ether. Physiological antagonists to combat collapse are caffeine and digitalis. Atropine. (Neurotic.) Symptoms : Redness or rash of the skin; nose, mouth, throat and bronchi become dry; voice becomes hoarse; swallowing difficult; pulse full and bound- ing, later feeble and rapid; pupils dilated; vision disordered; predisposition to laugh and talk loudly. There may be wild and maniacal delirium; and mental depression; suppression of the urine; convulsions; death occurs usually from asphyxia. Treatment: Wash out stomach with a solution of potassium permanganate (20 grains to 1 pint of water) ; precipitate alkaloid in stomach by dilute solu- tion of iodine in water (6 drops of tincture to 4 ounces) or of tannic acid; if not available give strong tea and an emetic. Apply an ice cap to the head; 265 TOXICOLOGY stimulate with strong coffee and eliminate the poison absorbed by the use of cathartics and diuretics. Treat symptoms as they arise. Physiological antagonists are morphine (cautiously administered), ether to control spasms, and caffeine for its effect on the heart and brain; pilocarpine. Belladonna. (Neurotic.) Symptoms and treatment same as atropine. Bichloride of Mercury. (Corrosive.) See Mercury. Caustic alkalies. (Corrosive.) Potassium and sodium hydroxides ; ammonia water ; quicklime ; lye. Symptoms; See general symptoms of corrosives. Treatment : Diluted acids, especially citric or tartaric; lemon or orange juice; vinegar; milk; oil. No emetics or stomach tube. Place patient on back. Warmth externally. Cold air. Give strychnine, opium, caffeine, aconite, and digitalis as indicated. Diluted hydrocyanic {prussic) acid must not be used. Cocaine. (Neurotic.) Symptoms: Dilated pupils; talkativeness, restlessness, excitement, delirium, hallucinations, mania, followed by depression; nausea, vomiting, numbness and tingling in hands, headache, dizziness; small, rapid pulse; irregular respira- tion ; later, convulsions, collapse, cyanosis, clammy skin, shock, possibly death. Treatment: Wash out the stomach with a solution of potassium permanga- nate (20 grains to 1 pint of water) or tannic acid or tea. Keep patient in recumbent position; apply external heat; fresh air; artificial respiration if necessary. Physiological antagonists are morphine, amyl nitrite, chloral, chloroform, and ether. Digitalis. (Neurotic.) Symptoms ; Pulse slow and full, then rapid and irregular; nausea, per- sistent vomiting, colic, and purging; thirst; vertigo and disturbances of vision and hearing; headache; muscular weakness; respiration rapid and feeble; cyanotic skin; coma and convulsions. Death occurs from sudden paralysis of the heart. Treatment: Wash out the stomach with tannic acid solution, or tea, or potas- sium permanganate solution (20 grains to 1 pint of water). Keep patient quiet and in a horizontal position. External heat, particularly over abdomen. Give magnesium sulfate, aromatic spirit of ammonia, alcohol, strychnine, oxygen, atropine. Artificial respiration if necessary. Physiological antagonists are aconite for the effects of a large dose and opium for the effects of its long-continued use. Food Poisoning. {See pages 377 and 379.) Symptoms: (Described on page 260.) Treatment : Must be adapted to the individual conditions found. If early treatment is possible, remove harmful contents from alimentary tract by use of stomach tube or emetics, high colon flushing, and active catharsis if there is no reason to suspect the presence of appendicitis or perforation of the in- testine. Saline infusion given hypodermically or intravenously should be used to aid in the elimination of the poisonous or noxious substance from the circu- lation. (This should be done by medical officers only.) 266 HANDBOOK OF THE HOSPITAL CORPS, II. S. NAVY Heroin. (Neurotic.) See Morphine. Hydrocyanic (prussic) acid and cyanides. (Neurotic.) Symptoms : Sudden collapse; unconsciousness ; a convulsive seizure; cyanotic face; clenched teeth; open and staring eyes; perhaps bloody froth on lips; and death in a few seconds; or, collapse; slow, labored, and gasping respiration; slow pulse; disturbed mental activity; dilated pupils; unconsciousness; vomit- ing; general convulsions with involuntary defeecation and urination, then coma, and death from paralysis of respiratory center. Odor of peach kernels on breath. Treatment : Stomach tube if possible. Diluted ammonia; opium, to relieve pain; alternate cold and warm affusions; atropine and heart stimulants; artificial respiration; recumbent position; external heat. Hyoscyamus. (Neurotic.) Symptoms and treatment same as atropine and belladonna. Iodine. (Corrosive and irritant.) Symptoms : Acrid taste in mouth; pain and sense of great warmth in throat; severe pain in oesophagus, stomach, and abdomen with violent vomiting and purging (vomited matter may contain traces of iodine) ; upper digestive tract and stomach corroded and stained a dark brown; intense thirst; rapid, feeble pulse; face pale; suppression of urine; convulsive movements and collapse. Treatment: Free administration of starch in water or any starchy sub- stance ; induce vomiting; give demulcent drinks; digitalis, atropine, or strych- nine hypodermically; external heat; careful nursing. Irritant gases. Symptoms: Irritant gases produce irritation and qprrosion of the respiratory tract, causing bronchitis, which may be more or less severe. Irritation of the eyes, mouth, stomach, and kidneys also are produced. Treatment: Remove the patient from the source of the gas; give inhalations of ammonia and begin artificial respiration at once. When free respiration is established, give magnesium oxide or diluted alkalies. Lead. Symptoms : A sense of constriction about the throat; metallic taste in mouth; cramps; stiffness of abdominal muscles; blue line around the gums; paralysis of upper extremities; dropped wrist; vomiting of white flaky matter and constipation. Treatment; Free administration of soluble sulfates, particularly magnesium sulfate, followed by milk and raw eggs; give emetics and use stomach tube; opium to allay irritation. Chronic poisoning is best treated by iodides to satura- tion of the system, sodium iodide or calcium iodide being the best. (Painters are subject to chronic lead poisoning.) Mercury. (Corrosive.) The metal itself is not poisonous but may form toxic compounds if it remains in the body for any length of time. Inorganic compounds of the mercuric type, as mercuric chloride (commonly called bichloride of mercury and cor- rosive sublimate), red mercuric iodide, yellow mercuric oxide, etc., are usually soluble and actively toxic, while those of the mercuro«. Period of communicability.—During the period of catarrhal symptoms and until the cessation of abnormal mucous membrane secretions—minimum period of 9 days; from 4 days before to 5 days after the appearance of the rash. 7. Susceptibility and immunity.—All persons must be considered susceptible until they have had the disease, except that most babies born of mothers who have had the disease are immune for the first six months of life. Natural immunity may last into adult life in rare instances. Acquired immunity is usual after recovery from an attack. Passive immunity may be estab- lished for a few weeks, but not more than 4, by the use of 4 to 10 cc of convalescent measles serum or 20 to 50 cc of whole blood of immunes, or if citrated blood is used, 25 to 60 cc. Measles. HYGIENE AND SANITATION 389 8. Prevalence.—Universal. Probably 80 to 90 per cent of all persons surviving to the twentieth year of life have had an attack, and rarely does a person go through life without having had measles. Occurs most commonly in children between 5 to 14 years of age, but many cases are in children under 5. Endemic in large population units. In remote or insular groups epidemics occur on contact with a case in a visitor. Highest incidence from March to June in North America. Frequency of epidemics depends on size of community, or proximity to a large center, amount of communi- cation between large and small population groups, accretion of population by births and other less exactly determined factors. Much more likely to result in death from complicating pneumonia in children under 2 than at higher ages. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms. Spe- cial attention to rise of temperature, Koplik spots and catarrhal symptoms in exposed individuals. 2. Isolation: During period of communicability for the sake of the patient as well as others. 3. Concurrent disinfection: All articles soiled with the secretions of the nose and throat. 4. Terminal disinfection: Thorough cleaning. 5. Quarantine: When the disease is very prevalent and in large com- munities, quarantine of exposed susceptible children may be impracticable and of no value. Exclusion of exposed susceptible school children and teachers from school until 14 days from last exposure may be justifiable under other conditions. This applies to exposure in the household. Exclusion of exposed susceptible children from all public gatherings for the same period. If the date of only exposure is reasonably certain, an exposed suscep- tible child of school age may be allowed to attend school for the first 7 days of the incubation period. Quarantining of institu- tions of young children and of wards or dormitories where exposure is suspected is of some value. Strict quarantine of wards of infants if a case occurs in an institution is important. 6. Immunization: By the use of the semm or whole blood of con- valescent patients, or of any healthy adults who have had measles, given within 5 days after exposure to a known case of measles, the attack in the exposed person may be averted in a high percentage of instances; if not averted, the disease is modified. Given later, but at a time prior to the clinical onset of the disease, convalescent serum usually modifies the severity of the attack and the patient probably acquires the usual last- ing immunity to the disease. 7. Investigation of source of infection; Search for exposed suscep- tible children under 3 years of age is profitable. Carriers are not known to occur. Every effort should be made to have all cases reported early in the disease by the physician, or, if there is none in attendance, by parent or guardian. The chief object of discovering cases is to assure suitable care for little children and immunization if practicable of those exposed under 5 years of age. 390 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY B. General measures : 1. Daily examination of exposed children and of other possibly exposed persons. This examination should include record of the body temperature. A nonimmune exposed individual exhibiting a rise of temperature of 0.5° C. or more should be promptly isolated pending diagnosis. 2. Schools should not be closed or classes discontinued where daily observation of the children by physician and nurse is pro- vided for. 3. Education as to special danger of exposing young children to those exhibiting fever and acute catarrhal symptoms of any kind, particularly during years and seasons of epidemic prevalence of measles. 4. In institutional outbreaks, immunization with convalescent serum of all minor inmates who have not had measles, is of value in checking the spread of infection and in reducing mortality. No new admissions and no visitors imder 16 years of age should be permitted in an institution for children, during a measles out- break in the community or in the institution. 5. The immunization of infants and children under 3 years of age with convalescent serum or whole adult blood in families where cases of measles occur in older children or adults should be encouraged by the department of health and by private physicians. Mumps. 1. Recognition of the disease.—Acute specific infection characterized by fever, swelling, and tenderness of the salivary glands, usually of the parotid, sometimes of the sublingual or submaxillary glands. Metastases occur sometimes in the ovaries and testicles. Epidemic occurrence is usual, es- pecially in schools, colleges, and barracks, of new recruits. Inflammation of Stenson’s duct may assist in early diagnosis. There are no laboratory aids of value. 2. Etiological agent.—A specific flltrahle virus. 3. Source of infection.—Secretions of the mouth and possibly of the nose. 4. Mode of transmission.—By direct contact with an infected person or with articles freshly soiled with the discharges from the nose and throat of such infected persons. 5. Incubation period.—From 12 to 26 days. The most common period 18 days, accepted as usual. A period of 21 days is not uncommon. 6. Period of communicability.—Unknown, but assumed to persist until the paro- tid gland has returned to its normal size. 7. Susceptibility and immunity.—Susceptibility believed to be general. Im- munity follows an attack but second attacks of the disease are not rare. Brief passive immunity may follow inoculation with convalescent serum or whole blood. 8. Prevalence.—This disease is decidedly less prevalent than the other common communicable diseases of childhood such as measles, whooping cough, and chicken pox. Winter and spring are the seasons of greatest prevalence. Its occurrence is sporadic and epidemic except in large cities, where it is endemic. HYGIENE AND SANITATION 391 t>. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: The diagnosis is usually made on swelling of the parotid gland. 2. Isolation: Separation of the patient from nonimmnne children and young children and young people and exclusion of the patient from school and public places for the period of presumed infec- tivity, particularly when the disease appears in children’s insti- tutions or among young recruits. 3. Concurrent disinfection: All articles soiled with the discharges of nose and throat of the patient. 4. Terminal disinfection: None. 5. Quarantine: None. Exposed susceptible persons should be regu- larly inspected for the onset, the presence of initial symptoms of the disease, such as fever, or swelling or pain of the parotid, or submaxillary glands, for 3 weeks from the date of last ex- posure. Exposed children medically certified as having had the disease should not be excluded from school as susceptibles. 6. Immunization: None. Passive temporary immunity by convales- cent serum or blood still in experimental stage. 7. Investigation of source of infection: Search for unreported or re- cent cases among associates of the patient in school or family or other group of young people. Carriers are not known to occur. B. General measures: None. Pneumonia, acute lobar. 1. Recognition of the disease.—An acute infection characterized by sudden onset with chill followed by fever, often pain in the chest, usually cough and dyspnoea. In many cases in children, vomiting and convulsions occur at the onset. Determination of the infecting microorganism by microscopic and cultural examination of the sputum is useful as an aid in therapy and for epidemiological studies. The X-ray may disclose pulmonary lesions before the stethoscope. 2. Etiological agent.—Various pathogenic bacteria commonly found in the nose, throat and mouth, such as the pneumococcus in about 95 per cent of the cases, and of these, 50 per cent types I and II; the bacillus of Friedlander; in occasional cases, the haemolytic streptococcus; the influenza bacillus, etc. 3. Source of infection.—Probably discharges from the mouth and nose of in- fected person or carrier and articles freshly soiled with such discharges. Except when already attacked by some respiratory infection, exposed indi- viduals rarely develop pneumonia as a result of transmission of infection by direct or indirect means from the patient. 4. Mode of transmission.—By direct contact with infected person or carrier, or with articles freshly soiled with the discharges of the nose and throat of such persons, and possibly from infected dust of rooms occupied by infected persons. 5. Incubation period.—Believed to be short, usually 1 to 3 days—not well deter- mined. 6. Period of communicability.—Unknown; presumably until the discharges of the mouth and nose no longer carry the infectious agent in an abundant amount or in a virulent form. 392 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 7. Susceptibility and immunity.—Susceptibility is general, accentuated by wet and cold and exposure, and apparently under certain conditions by bodily and mental fatigue, and by alcoholism. Natural immunity may occur, but is doubtful. Acquired immunity to the particular microorganism may fol- low an attack of pneumonia; such immunity is of short duration. Artificial active or passive immunity cannot be relied upon. 8. Prevalence.—Common, and affecting at one time or other, between adoles- cence and old age, a large proportion of the population. No race or color or either sex is exempt from likelihood of having this disease. Occurs in all climates and seasons, but most often in winter and spring and in regions where cold, windy, changeable, and inclement weather prevails. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting; Clinical symptoms. Specific infecting organisms may be determined by serological and bacteriological tests early in the course of the disease, which may give basis for epidemiological studies and for specific serum therapy. 2. Isolation: Medical aseptic technique preferably at home. 3. Concurrent disinfection: Discharges from the nose and throat of the patient. 4. Terminal disinfection: Thorough cleaning and airing. 5. Quarantine: None B. General measures: 6. Immunization: None, 1. Whenever practicable and particularly in institutions, barracks, and on shipboard, crowding in living and sleeping places should be avoided. The general resistance should be conserved by good food, fresh air, sufficient sleep, temperance in the use of alcoholic beverages, and other hygienic measures. Scarlet fever 1. Recognition of the disease.—Sudden onset with nausea, vomiting, fever, and sore throat; rash (bright red spots on subcuticular flush) on second or third day. Cases occur without eruption, when provisional diagnosis may be made on sore throat, fever, vomiting, and history of exposure. The Schultz-Charlton blanching phenomenon may be used when rash has recently appeared: one-tenth to one-half cc convalescent serum or scarlet fever anti- toxin is injected into skin where rash exists, which causes local blanching in 6 to 36 hours if rash is scarlatinal; absence of blanching, however, does not rule out scarlet fever. 2. Etiological agent.—A haemolytic streptococcus. 3. Source of infection.—Discharges from the nose, throat, ears, abscesses, or wound surfaces of sick or convalescent patients, and articles freshly soiled therewith. The nose and throat discharges of carriers may also spread the disease. 4. Mode of transmission.—Directly by contact with an infected person, indirectly by articles freshly soiled with discharges of an infected person, or through contaminated milk or milk products, not by skin desquamation. 5. Incubation pei'iod.—Two to seven days, usually three to four days. 6. Period of communicability.—'Usually until 3 weeks from the onset of the dis- ease, without regard to the stage or extent of desquamation, but until all abnormal discharges have ceased and all open sores or wounds have healed. HYGIENE AND SANITATION 393 Adults convalescent from scarlet fever appear to be less likely to transmit infection than are children. The infectious agent is more likely to be transmitted in colder seasons of the year. 7. Susceptibility and immunity.—Susceptibility is not general, particularly among adults. Unnoticed infections occur and produce immunity. Lasting immunity is usual after an attack, but not Invariable, as second attacks occur. Artificial passive immunity of a few weeks may be developed by human convalescent serum. Artificial active immunity of uncertain dura- tion can be developed in a considerable proportion of susceptible persons by the use of a suitable streptococcus antigen. 8. Prevalence.—Found in all parts of the world but unimportant in tropics and of low incidence in subtropical areas of North America. Commoner in urban than in rural areas. About 5 per cent of total deaths from scarlet fever occur in children under 1 year of age. Most common in winter and spring. 9. Methods of control: A. The infected individual, contacts and environment: 1. Recognition of the disease and reporting: By clinical symptoms. 2. Isolation; In home or hospital, maintained in each case until the end of the period of communicability. If medical inspection is not available, isolation for 21 days from onset for uncomplicated cases. 3. Concurrent disinfection: Of all articles which have been in contact with a patient and all articles soiled with discharges of the patient. 4. Terminal disinfection: Thorough cleaning. 5. Quarantine: Exclusion of exposed children and teachers from association with children, and food handlers from their work, until 7 days have elapsed since last exposure to a recognized case. 6. Immunization: Exposed susceptibles, as determined by the Dick test, may be passively immunized by convalescent scarlet fever serum or scarlet fever antitoxin, under special circumstances. 7 Investigation of source of infection: Search for individual source in contact cases or carrier, and in unpasteurized milk and milk products. It is important to discover undetected cases and convalescent and contact carriers. B. General measures: 1. Daily examination of exposed children and of other possibly exposed persons for a week after last exposure. Encourage removal of young susceptible contacts in the family to homes of adult friends for duration of communicable stage in the patient. Septic sore throat. 1. Recognition of the disease.—Acute sore throat appearing in epidemic out- breaks, often of a highly virulent character, and accompanied by various general septicsemic manifestations. The onset is likely to be abrupt with chill, high temperature, and vomiting. 2. Etiological agent.—Streptococcus (haemolytic type).1 3. Source of infection.•—The human naso-pharynx, usually the tonsils, any case of acute streptococcus inflammation of these structures being a potential source of infection, including the period of convalescence of such cases. 1 Bovine mastitis of staphylococcus origin may lead to epidemic outbreaks of gastro- intestinal disturbance in those who drink unpasteurized milk from a cow so infected. 394 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The udder of a cow infected by the milker is a common source of infection. In such udders the physical signs of mastitis may he absent.3 4. Mode of transmission.—Direct or indirect human contact; consumption of raw milk contaminated by case or carrier or from an infected udder. 5. Incubation period.—One to three days. 6. Period of communicability.—In man, presumably during the continuance of clinical symptoms; in the cow, during the continuance of discharge of the streptococci in the milk, the condition in the udder tending to a spontane- ous subsidence. The carrier stage may follow convalescence and persist for some time. 7. Susceptibility and immunity.—Susceptibility general, but somewhat less, in young children. Immunity, either natural or acquired, is rare and uncer- tain, if it occurs at all. 8. Prevalence.—Usually in epidemics, in any geographic area except where milk supply is pasteurized. Most cases in adolescents and adult milk drinkers. Most often in spring and early summer, but may occur at any season. 9. Methods of control: A. The infected individual, contacts, and environment 1. Recognition of the disease and reporting: Clinical symptoms. Bacteriological examination of the lesions or discharges from the tonsils and naso-pharynx may be useful. 2. Isolation; During the clinical course of the disease and convales- cence, and particularly exclusion of the patient from participa- tion in the production or handling of milk or milk products. 3. Concurrent disinfection: Articles soiled with discharges from the nose and throat of the patient. 4. Terminal disinfection: Cleaning. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of sources of infection: Search for cases and carriers among milkers and other handlers of unpasteurized milk, and for mastitis in milk cows. B. General measures: 1. Exclusion of suspected milk supply from public sale or use until pasteurized. The exclusion of the milk of an infected cow or cows in small herds is possible when based on bacteriological examination of the milk of each cow, and preferably the milk from each quarter of the udder at frequent intervals. Exclusion of human cases or carriers from handling milk or milk products. 2. Pasteurization of all milk. 3. Education in the principles of personal hygiene and avoidance of the use of common towel, drinking and eating utensils. 4. In the absence of an epidemic, the milk of any cow with evidence of mastitis should be excluded from sale or use as a protection in addition to pasteurization. Tuberculosis, pulmonary. 1. Recognition of the disease.—Evidence of present or past infections in the absence of clinical symptoms can be determined by a variety of specific tuberculin reactions, among which the Mantoux intradermal test is the 2 Mastitis in the cow, due to bovine streptococci, is not a cause of septic sore throat in human beings unless a secondary infection of the udder by a human type of strepto- coccus takes place. HYGIENE AND SANITATION 395 most reliable. In the presence of early constitutional symptoms with or without pulmonary signs, the existence or location of pulmonary or other thoracic lesions can best be revealed by the X-ray. When fever, cough, loss of appetite and weight, and physical signs on auscultation and percussion are found, the pulmonary lesion is already well developed. Discovery of tubercle bacilli in the sputum confirms the diagnosis not infrequently in early cases but is an evidence usually of a well-advanced lesion. 2. Etiological agent.—Mycobacterium tuberculosis (hominis) (Bacillus tuber- culosis (human)). Tubercle bacilli of bovine type have been isolated from pulmonary lesions in man; avian type rarely. 3. Source of infection.—The specific microorganism present in the discharges, or articles freshly soiled from the discharges, from any open tuberculosis lesions, the most important discharge being sputum. Of less importance are discharges from the intestinal and genitourinary tracts, or from lesions of the lymph nodes, bone, and skin. 4. Mode of transmission.—Usually through the discharges of the respiratory tract, occasionally through those of the digestive tract, by direct or indirect contact with infected persons, by means of coughing, sneezing, or other droplet infection, by kissing, by the use of contaminated eating and drink- ing utensils, and possibly by contaminated flies and dust. Infection rarely occurs from casual contact, but usually results from the continued type of exposure characteristic of family relationships. 5. Incubation period.—Variable and dependent upon the type of the disease. 6. Period of communicability.—As long as the specific microorganism is elimi- nated by the host. Commences when a lesion becomes an open one, i. e., discharging tubercle bacilli, and contihues until it heals or death occurs. The degree of communicability varies with the number and virulence of the bacilli discharged, the frequency of exposure, and the susceptibility of the persons exposed. 7. Susceptibility and immunity.—Susceptibility is general; in children greater than in adults; in aboriginal races more than among races long exposed to the disease; in the undernourished, fatigued, and neglected more than in the well fed and well cared for; in those exposed to dusty trades, and in particular to silica dust, more than in persons with outdoor occupations in clean air. Resistance of some degree is developed by age and by the main- tenance of good nutrition. 8. Prevalence.—Among the most common communicable diseases of man, with but slight variations of occurrence of infection, although considerable var- iation in mortality rate according to race. At present in some modern occidental nations its incidence as a disease has fallen markedly, and both incidence and deaths continue to fall from year to year. Infection occurs more commonly in childhood (from infancy to adolescence) than at later ages. Mortality highest among males between 25 and 40 and among females about 5 years earlier. Aboriginal races when first exposed develop the disease in a rapidly fatal form. 9. Methods of control: A. The infected individual, contacts, and environment 1. Recognition of the disease and reporting; By thorough physical examination supplemented by use of the X-ray and tuberculin testing when necessary and confirmed by bacteriological exami- nation of sputum and other materials. Early discovery in con- tacts, particularly in family groups exposed to an open case of tuberculosis (“positive” sputum), is of great importance. 154294 °—-39 26 396 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 2. Isolation of such “open” cases as do not observe the precautions necessary to prevent the spread of the disease may prove advis- able. A period of hospital or sanatorium treatment is very desirable in all cases to remove the patient as a focus of infec- tion in his home, and to teach him the hygienic essentials of tuberculosis control as well as to increase his chances of recovery. 3. Concurrent disinfection: Of sputum and articles soiled with it. Particular attention should be paid to prompt disposal or disin- fection of sputum itself, of handkerchiefs, cloths, or paper soiled therewith, and of eating utensils used by the patient. 4. Terminal disinfection: Cleaning and renovation. 5. Quarantine: None. 6. Immunization : None. 7. Investigation of source of infection: In spite of the length and uncertainty of the incubation period and the numerous possible sources of infection, a systematic effort should be made to dis- cover the probable source in each case and to identify other cases of the same origin, by thorough examination by X-ray, physical examination, and where appropriate by tuberculin test of family and household contacts. B. General measures: 1. Education of the public in regard to the danger of tuberculosis, the mode of spread and the methods of control, with especial stress upon the danger of exposure and infection in early childhood. 2. Provision of dispensaries and visiting-nurse service for discovery of early cases and supervision of home cases. 3. Provision of adequate sanatorium facilities for isolation and treatment of active cases. Two beds per annual tuberculosis death in the community is an adequate ratio. 4. Provision of open-air schools and preventoria for infected chil- dren not yet showing clinical signs of the disease. 5. Improvement of housing conditions and nutrition of the poor. (5. Elimination of silica dust in certain industrial establishments. 7. Improvement of habits of personal hygiene and betterment of living conditions among the underprivileged. 8. Separation of babies from tuberculous mothers at birth. 9. Pasteurization of all milk supplies. 10. Eradication of tuberculosis in cattle. 11. AVhere the disease is endemic and the incidence high particularly among little children, the routine use of B. C. G. (bile Calmette Guerin) vaccine in infancy for active immunization has been suggested. Tuberculosis, other than pulmonary. 1. Recognition of the disease.—By local manifestations, by constitutional reac- tions, by specific reactions, and by microscopic identification of the tubercle bacillus in the lesions or their discharges. 2. Etiological agent.—Mycobacterium tuberculosis (hominis et bovis) (Bacillus tuberculosis (human and bovine)). 3. Source of infection.—Discharges from mouth, nose, bowel, and genito- urinary tract of infected human beings; the discharging lesion of bones, joints, and lymph glands; articles freshly soiled with such discharges; milk from tuberculous cattle. HYGIENE AND SANITATION 397 4. Mode of transmission.—By direct contact with infected persons, by contami- nated food, and possibly by contact with articles freshly soiled with the discharges of infected persons. 5. Incubation period.—Unknown. 6. Period of communicability.—Until discharging lesions are healed. 7. Susceptibility and immunity.— (See statement under this heading in Pul- monary tuberculosis.) 8. Prevalence.—Much less common than the pulmonary form and more rapidly falling in incidence, representing about 10 per cent of total cases and deaths from the disease. Especially common in infants and young children where intimately exposed to parent infection and to bovine infection through unpasteurized milk from tuberculous cattle. 9. Methods of control: A. The infected individual, contacts and environment: 1. Recognition of the disease and reporting: Clinical signs and symp- toms confirmed by bacteriological and serological examinations. 2. Isolation: None. 3. Concurrent disinfection: Discharges and articles freshly soiled with them. 4. Terminal disinfection: Cleaning. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of Infection; Search should be made for possible original source in family, household, or other intimate contacts, and to discover previously unrecognized cases of similar origin, such a search to be aimed at discovery of infected but latent or arrested cases as well as those showing an active proc- ess. Special inquiry and investigation should be made to dis- cover possible source of bovine tubercle infection where unpas- teurized milk has been used in the family or particularly used uncooked, by the patient. B. General measures: 1. Pasteurization of milk and milk products and inspection of meats. 2. Eradication of tuberculosis in dairy cattle. 3. Patients with open lesions should be prohibited from handling foods. 4. Adequate hospital, sanatorium, preventorium, and out-patient facil- ities for discovery, control, and clinical management. Whooping cough (Pertussis). 1. Recognition of the disease.—An acute infection involving trachea and bron- chi and characterized by an initial catarrhal stage with slight fever, and a paroxysmal stage in which the paroxysmal cough ends in a sonorous or whooping inspiration often accompanied by vomiting. Identification of the Bordet-Gengou bacillus in the tenacious tracheo-bronchial mucus can be made in a high percentage of cases during the early and paroxysmal stages of the disease before the whoop develops, and less readily from the fourth to the sixth week after the onset of the disease by the use of special cough culture plates held before the mouth during a spontaneous or induced paroxysm of coughing. A definite lymphocytosis in the pre-parox- ysmal stage may assist the clinical diagnosis. 2. Etiological agent.—Haemophilus pertussis (Bacillus of Bordet-Gengou). 3. Source of infection.—Discharges from the laryngeal and bronchial mucous membranes of infected persons. 398 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 4. Mode of transmission.—Contact with an infected person, or with articles freshly soiled with the discharges of such person. 5. Incubation period.—Commonly 7 days, almost uniformly within 10 days, and not exceeding 16 days. 6. Period of communicability.—Particularly communicable in the early catarrhal stage before the characteristic whoop makes a clinical diagnosis possible. The catarrhal stage occupies from 7 to 14 days. After the characteristic whoop has appeared, the communicable period continues certainly for 3 weeks. Even if the spasmodic cough with whoop persists longer than this it is most unlikely that the infecting organism can be isolated from the dis- charges. The communicable stage must be considered to extend from 7 days after exposure to an infected individual to 3 weeks after the develop- ment of the characteristic whoop. 7. Susceptibility and immunity.—Susceptibility is general. There is no natural immunity. The greatest susceptibility is in children between 6 months and 5 years of age, after which there is some decrease. One attack confers a definite and prolonged immunity, although second attacks do occur. A brief passive immunity may be conveyed to young children by convalescent serum or adult whole blood. Artificial immunity is still of doubtful value and as yet of no definite reliance. Susceptibility is apparently higher in females at all ages than in males. 8. Prevalence.—Very prevalent, and a common disease among children every- where regardless of race, climate, or geographical location. About half the reported cases in cities are in children under 5 years of age, and 90 per cent in children under 10. Incidence and fatality rates are higher among females. Somewhat less prevalent in tropical than in temperate climates. Seasonal incidence variable, but mortality higher usually in spring months in North America. Cyclical occurrence irregular. 9. Methods of control. A. The infected individual, contacts and environment 1. Recognition of the disease and reporting: Clinical symptoms, supported by a differential leucocyte count, and confirmed where possible by bacteriological examination of bronchial secretions. A positive diagnosis may be made by bacteriological examination of laryngeal discharges as early as 1 week before the develop- ment of the characteristic cough. 2. Isolation: Separation of the patient from susceptible children, and exclusion of the patient from school and public places for the period of assumed infectivity. It is of particular impor- tance to protect children under 3 years of age against contact with any other children with cough and fever, of whatever origin, and especially if whooping cough is suspected or is known to be prevalent. Isolation of children over 2 years of age is impracticable, and even those under 2 shoiild not be insisted upon at the expense of fresh air in the open if weather permits. 3. Concurrent disinfection: Discharges from the nose and throat of the patient and articles soiled with such discharges. 4. Terminal disinfection: Cleaning of the premises used by the patient. 5. Quarantine: Limited to the exclusion of nonimmune children from school and public gatherings for 10 days after their last ex- posure to a recognized case. This precaution may be omitted HYGIENE AND SANITATION 399 if exposed nonimmune children are observed with care by a physician or nurse on their arrival at school each day for 10 days after their last exposure to a recognized case. 6. Immunization: Use of prophylactic vaccination is recommended by some observers, but is still considered to be of doubtful reliability. 7. Investigation of source of infection: An effort should be made to discover undiagnosed and unreported cases, with the main object in view of protecting young children from exposure, and thus reducing the mortality. Postponement of the age of infection at least until school age and great care in the man- agement of the disease in young children offer some hope of reducing deaths from whooping cough although reduction of incidence by any means appears unlikely. Carriers in the exact sense of this term are not known to occur. B. General measures; Education in habits of personal cleanliness and in the dangers of association or contact with those showing catarrhal symptoms with cough. GROUP II. DISEASES TRANSMITTED BY DISCHARGES FROM THE INTESTINAL TRACT Cholera. Dysentery, amoebic. Dysentery, bacillary. Hookworm disease. Paratyphoid fever. Typhoid fever. Cholera. 1. Recognition of the disease.—In a few mild cases, diarrhoea may be the chief or only symptom. In the typical case, rice-water stools, vomiting, and general symptoms of dehydration occur with thirst, pain, and coma. The cholera vibrios are found in the stools. 2. Etiological agent.—Vibrio comma, (Spirillum cholerce.) 3. Source of infection.—Bowel discharges and vomitus of infected persons, and faeces of convalescent or healthy carriers. Ten per cent of contacts may he found to be carriers. 4. Mode of transmission.—By food and water polluted by infectious agent; by contact with infected persons, carriers, or articles freshly soiled by their discharges; by flies. 5. Incubation period.—One to five, usually three days, occasionally longer if the healthy carrier stage, before development of symptoms, is included. 6. Period of communicability.—Usually 7 to 14 days or longer and until the infectious organism is absent from the bowel discharges. A high degree of communicability is usual. 7. Susceptibility and immunity.—Susceptibility is general, although natural im- munity appears to exist to a limited degree. Acquired immunity is uncertain. Active artificial immunity for about 1 year may be obtained by vaccines. 8. Prevalence.—Rare in North America. Appears in epidemic form frequently in the Philippines. Does not occur sporadically, except as an isolated case is discovered in the course of maritime quarantine enforcement. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms con- firmed by bacteriological examination of stools. 400 HANDBOOK OF THE HOSPITAL CORPS, U. S, NAVY 2. Isolation of patient in hospital or screened room during com- municable period. 3. Concurrent disinfection: Prompt and thorough disinfection of the stools and vomited matter. Articles used by and in connection with the patient must be disinfected. Food left by the patient should be burned. 4. Terminal disinfection: The room in which a sick patient was isolated should be thoroughly cleaned. 5. Quarantine: Contacts for 5 days from last exposure, or longer if stools are found to contain the cholera vibrio. 6. Immunization: Prophylactic immunization of contacts is useful and advisable. 7. Investigation of source of infection: Search for contaminated food and water as common origin of groups of cases, and for unreported cases and for carriers. B. General measures: 1. Rigid personal prophylaxis of attendants by scrupulous cleanli- ness, disinfection of hands each time after handling patient or touching articles contaminated by dejecta, the avoidance of eating or drinking anything in the room of the patient, and the prohibition of those attendant on the sick from entering the kitchen. 2. The bacteriological examination of the stools of all contacts to determine carriers. Isolation of carriers. 3. Water should be boiled, if used for drinking or toilet purposes, or if used in washing dishes or food containers, unless the water supply is adequately protected against contamination or is so treated, as by chlorination, that the cholera vibrio cannot sur- vive in it. 4. Careful supervision of food and drink: Where cholera is preva- lent, only cooked foods should be used. Food and drink after cooking or boiling should be protected against contamination, as by flies and human handling. C. Epidemic measures: Inspection service for early detection and isolation of cases; examination of persons exposed in infected centers for de- tection of carriers, with isolation or control of carriers; cleaning of rooms occupied by the sick, and the detention, in suitable camps for 5 days, of those desirous of leaving for another locality. Those so detained should be examined for detection of carriers. Dysentery, amoebic (Amoebiasis). 1. Recognition of the disease.—Insidious and undetermined onset characterizes mild acute cases, with digestive disturbance, anorexia, diarrhoea or consti- pation, and usually little abdominal discomfort. Severe acute cases fol- lowing massive infection may simulate acute appendicitis, or other acute surgical abdominal condition with high temperature and severe prostration. The subacute and chronic forms of the disease vary widely in the extent of local and constitutional symptoms. There may or may not be diarrhoea or constipation; or these may alternate in the same patient. 2. Etiological agent.—Endamoeba histolytica. 3. Source of infection.—The bowel discharges of infected persons and of carriers. 4. Mode of transmission.—By drinking contaminated water and by eating in- fected foods, especially those that are commonly served cold and moist, and HYGIENE AND SANITATION 401 hand-to-mouth transfer of infected material; from moist objects soiled with discharges of an Infected individual; by flies. 5. Incubation period.—From 2 days in severe infections to several months in subacute and chronic cases; commonly 3 to 4 weeks. 6. Period of communicability.—During course of infection and until repeated microscopic examination of stools shows absence of the Endamoeba his- tolytica (either trophozoites or cysts). Direct transmission unusual. 7. Susceptibility and immunity.—Susceptibility to infestation is general; im- munity uncertain; no artificial immunity. 8. Prevalence.—Not a common disease clinically in continental North America. Epidemic outbreaks are rare. It is estimated that almost 5 per cent of the population are carriers of cysts. 9. Methods of control: A. The infected individual, contacts and environment: 1. Recognition of the disease and reporting; Clinical symptoms confirmed by microscopic examination of stools. 2. Isolation: None. 3. Concurrent disinfection: Sanitary disposal of the bowel discharges. Hand washing after use of toilet. 4. Terminal disinfection; Cleaning. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection; Microscopic examination of stools of inmates of the household, or of work associates of the infected person, and of other suspected contacts, should be supplemented by search for direct contamination of water and foods by human fseces. B. General measures: 1. Sanitary disposal of human faeces. 2. Protection of potable water supplies against faecal contamination, and boiling drinking water where necessary. Chlorination of water supplies as generally used has been found inadequate for the destruction of cysts. 3. Supervision of the general cleanliness, of the personal health and sanitary practices of persons preparing and serving food in pule lie eating places, especially moist foods eaten raw. 4. Education in personal cleanliness, particularly washing hands with soap and water after evacuation of the bowel. 5. Control of fly breeding and protection of foods against fly con- tamination by screening. 6. It is of importance that all cross connections between potable and polluted water supplies be forbidden. Systematic inspection should be made to discover them, and the supply should be dis- connected until such cross connections have been eliminated. 7. Instruction of convalescent and chronic carriers in personal hy- giene, particularly as to sanitary disposal of faecal waste, and hand washing after use of toilet. C. Epidemic measures: In case of epidemics due to relatively massive doses of infectious material, active measures should be employed to dis- cover the source of infection, and to warn the public and the medi- cal profession of the early and characteristic symptoms, and of the serious immediate and remote results of such infection. 402 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Dysentery, bacillary. 1. Recognition of the disease.—The typical case exhibits an acute onset, fever, tenesmus, with frequent stools containing blood and mucus. One or more of a large number of possible types of the dysentery bacillus can usually be found in the stools in the first 2 days of the disease. 2. Etiological agent.-— Shigella dysenterise and Shigella paradysenterise. 3. Source of infection.—The bowel discharges of infected persons. 4. Mode of transmission.—By eating infected foods, and by hand-to-mouth trans- fer of infected material; by flies, from objects soiled with discharges of an infected individual or of a carrier; by drinking contaminated water. Pol- luted milk and water are less common vehicles of this disease than is the case with typhoid fever. 5. Incubation period.—2 to 7 days. 6. Period of communicability.—During the febrile period of the disease and until the microorganism is absent from the bowel discharges, sometimes as long as 4 weeks. 7. Susceptibility and immunity.—Susceptibility is general among children, but less so, and the disease less severe, in adults. A relative and not perma- nent immunity follows recovery from the disease. 8. Prevalence.—Endemic, epidemic, and sporadic, but shares with other enteric infections in striking and progressive reduction wherever water supplies are rendered safe, sewage is disposed of in a sanitary manner, milk is pasteurized, and infant hygiene is of a good order. Most common in the summer months and in subtropical and tropical areas. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting; Clinical symptoms con- firmed by serological and bacteriological tests; groups of cases of acute diarrhoeal disorder should always be reported at once. 2. Isolation: Infected individuals during the communicable period of the disease, particularly rigid personal precautions by at- tendants. 3. Concurrent disinfection: Bowel discharges. 4. Terminal disinfection; Cleaning. 5. Quarantine: None. 6. Immunization: Vaccines may give some immunity. Owing to severe reactions their use is not recommended, nor should vacci- nation be made compulsory except under extreme emergency. 7. Investigation of source of infection: Search for a common source in contaminated food and water, and for carriers particularly among food handlers, should be undertaken as in the case of typhoid fever. B. General measures: 1. Protection and purification of public water supplies, together with prevention of subsequent contamination. 2. Pasteurization of public milk supplies; use of boiled milk for infant feeding. 3. Supervision of preparation and handling of other foods, particularly those which are moist and eaten raw. 4. Hand washing, by food handlers in particular, following use of toilet. 5. Prevention of fly-breeding; screening. 6. Sanitary disposal of human excreta. HYGIENE AND SANITATION 403 7. Persons known to be infected, and their attendants, should he excluded from handling food for public consumption, and from handling the family food supply if possible. 8. The exercise of rigid precautions in known cases of bacillary dysen- tery is requisite but is inadequate as a safeguard against the ever-present risk of infection from concealed sources. Reduction of high infant mortality rates is dependent upon prevention of diarrhoea and enteritis. Infant hygiene, including breast feeding, scrupulous cleanliness at all times in the preparation and han- dling of food for children, and continuous attention to diet in order to avoid minor digestive disturbances that may lower resistance to the infection will do much toward accomplishing this aim. As a precautionary measure, all cases of infantile diarrhoea should be regarded as bacillary dysentery. Prevention of epidemics of bacillary dysentery by guarding against massive dissemination of infection should be a major concern, particularly in prisons, camps, and institutions. Ancylostomiasis (Hookworm disease). 1. Recognition of the disease.-—Light degrees of infestation may produce no striking clinical symptoms, although some degree of secondary anaemia and slight interference with bodily and mental development may be noted. A medium degree of infestation shows marked anaemia and, if before puberty, definite physical and mental retardation, and a dry dirty-yellow skin. Severe infestations may show petechiae and atrophy of the skin, oedema, general or of dependent parts, extreme anaemia, anxious, stupid expression, prominent abdomen. The diagnosis is definitely established by finding ancylostoma ova in the stools, by smear or flotation methods. 2. Etiological agent.—In the United States, Necator americanus, rarely Ancy- lostoma duodenale. 3. Source of infestation.—Faeces of infested persons. Infestation generally takes place through the skin, occasionally by the mouth. 4. Mode of transmission.—The larval forms pierce the skin, usually of the foot, and, passing through the lymphatics to the vena cava and the right heart, thence in the blood stream to the lungs, they pierce the capillary walls and pass into the alveoli. They then pass up the bronchi and trachea to the throat, whence they are swallowed and finally lodge in the small intestine. Also by drinking water containing larvae, by eating soiled food, by hand-to- mouth transmission of the eggs or larvae from objects soiled with infested discharges. The chief reservoir of infectious material is contaminated soil. 5. Incubation period.—No incubation period occurs comparable to that observed in bacterial and virus infections. Onset of symptoms varies widely in time, according to the intensity of the infestation, from 2 to 3 weeks in massive infestations (commonly 7 to 10 weeks), to many months or even years where infestation or reinfestation is by small numbers of worms. The free living form may exist in the soil under favorable conditions for several weeks. Eggs are found in the stools in about 4 to 6 weeks after the larvse penetrate the skin, and develop the next generation of larvae 5 to 8 days after being deposited on soil, under favorable conditions. 6. Period of communicability.—As long as the parasite or its ova are found in the bowel discharges of an infested individual. Contaminated soil may remain infective for 5 months in the absence of freezing. An individual can communicate the disease to others only by the indirect method of pollution of the soil with his faeces. As long as mature female worms are 404 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY in the Intestine, eggs, if deposited in the faeces in warm moist soil, become sources of infestation, especially where the soil is sandy. 7. Susceptibility and immunity.—Susceptibility to infestation is universal, although among adults, especially Negroes, infestations are likely to be less heavy than among children and in the white races. Immunity does not develop after infestation. 8. Prevalence.—Endemic widely throughout those climatic belts where frost does not last more than 6 weeks in the year, and particularly where the soil is sandy. In rural areas of the Southern States of the United States, particularly among white children of school age; less commonly and less severely among Negro children. Damp summer weather increases the prev- alence of infestation. During the past two decades there has been some decrease in prevalence and severity of the disease in continental United States. Prevalence is high in Puerto Rico. 9. Methods of control: A. The infested individual, contacts, and environment: 1. Recognition of the disease and reporting: Microscopic examination of bowel discharges. 2. Isolation: None. 3. Concurrent disinfestation: Sanitary disposal of bowel discharges to prevent contamination of soil and water. 4. Terminal disinfestation: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infestation: Each case and carrier is a potential or actual spreader of the disease and should be brought under treatment and his family contacts examined. 8. Treatment; Appropriate treatment of infested persons with carbon tetrachloride, oil of chenopodium, or tetra-chlor-ethylene, to rid the intestinal canal of the parasite and its ova. B. General measures: 1. Education as to dangers of soil pollution and methods of pre- vention. 2. Prevention of soil pollution by installation of sanitary disposal system for human discharges, especially sanitary privies in rural areas. 3. Personal prophylaxis by cleanliness and the wearing of shoes. Paratyphoid fever. 1. Recognition of the disease.—A general infection with the paratyphoid bacil- lus characterized especially by continued fever and involvement of the lymphoid tissues in the intestine, enlargement of the spleen, and a variety of constitutional symptoms, sometimes rose spots on the trunk, usually diarrhoeal disturbance. The infecting microorganism may be found in the faeces, blood, and urine. This disease should not be confused with food poisoning or with infection due to enteritidis bacilli of animal origin. 2. Etiological agent.—Salmonella paratyphi (Paratyphoid bacillus A) ; Salmon- ella shottmiilleri (Paratyphoid bacillus B). 3. Source of infection.—Bowel discharges and urine of infected persons, and water or foods contaminated with such discharges of infected persons or of healthy carriers. Healthy carriers may be numerous in an outbreak. 4. Mode of transmission.—Directly by personal contact: indirectly by contact with articles freshly soiled with the discharges of infected persons or through milk, water, or food contaminated by such discharges, probably by flies. HYGIENE AND SANITATION 405 5. Incubation period.—Four to ten days; average, seven days. 6. Period of communicability.—From the appearance of prodromal symptoms, throughout the illness and relapses, during convalescence, and until re- peated bacteriological examination of discharges shows absence of the infecting organism. 7. Susceptibility and immunity.—Susceptibility is general. Natural immunity probably exists in some adults. Acquired immunity is usually permanent after recovery from the disease. Artificial active immunity of probably 2 years’ duration can be developed by the use of vaccines. 8. Prevalence.—Frequency has fallen with that of typhoid fever until in most parts of North America it is relatively rare, occurring sporadically or in small local carrier or contact epidemics. Probably nowhere endemic in North America. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms confirmed by specific agglutination test, or by bacteriological examination of blood, bowel discharges, or urine. 2. Isolation: In fly-proof room, preferably under hospital conditions, of such cases as cannot command adequate sanitary environ- ment and nursing care in their homes. 3. Concurrent disinfection; Disinfection of all bowel and urinary discharges and articles soiled with them. 4. Terminal disinfection; Cleaning. 5. Quarantine: None. 6. Immunization: Of exposed susceptibles. 7. Investigation of source of Infection: Search for common source in polluted water, milk, shellfish or other food, and individual sources as unreported cases and carriers. B. General measures: 1. Protection and purification of public water supplies. 2. Pasteurization of public milk supplies. 3. Limitation of collection and marketing of shellfish to those from approved sources. 4. Supervision of other food supplies, and of food handlers. 5. Prevention of fly breeding. 6. Sanitary disposal of human excreta. 7. Extension of immunization by vaccination to persons especially subject to exposure by reason of occupation and travel,, to those living in areas of high endemic incidence of typhoid fever and to those for whom the procedure can be systematically and economically applied, as military forces and institutional popu- lations, depending on prevalence of the disease. 8. Discovery and supervision of partyphoid carriers and their ex- clusion from the handling of foods. 9. Exclusion of suspected milk supplies on epidemiological evidence pending discovery and elimination of the personal or other cause of contamination of the milk. 10. Exclusion of suspected water supplies until adequate protection or purification is provided unless all water used for toilet, cook- ing, and drinking purposes is boiled before use. 406 HANDBOOK OF THE HOSPITAL CORPS, XJ. S. NAVY Typhoid fever. 1. Recognition of the disease.—A general infection with the typhoid bacillus, characterized by a continued fever, and by involvement of the lymphoid tissues especially with enlargement and often ulceration of Peyer’s patches, enlargement of the spleen,, usually rose spots on the trunk, diarrhoeal dis- turbance, and a variety of severe constitutional disturbances accompanying parenchymatous involvement of various viscera. The infecting micro- organism can be found in the blood, the faeces, and the urine. 2. Etiological agent.—Eberthella typhosa (Bacillus typhosus). 3. Source of infection.—Bowel discharges and urine of infected individuals. Healthy carriers are common. 4. Mode of transmission.—Conveyance of the specific microorganism by direct or indirect contact with a source of infection. Among indirect means of transmission are contaminated water, milk, and shellfish, and probably flies. 5. Incubation period.—From 3 to 38 days, usually 7 to 14 days. 6. Period of communicability.—From the appearance of prodromal symptoms, throughout the illness and relapses during convalescence, and until repeated bacteriological examinations of the discharges show continuous absence of the infecting organism. 7. Susceptibility and immunity.—Susceptibility is general. Natural immunity exists to some extent in adults. Acquired immunity of permanent duration usually follows recovery from the disease. Artificial active immunity of probably 2 years’ duration can be developed by the use of typhoid vaccine. 8. Prevalence.—Widespread throughout the world regardless of race, age, sex, climate, or geography. Formerly in most large cities of North America and in many extensive rural areas in endemic and epidemic form, and still endemic in some rural areas of the southern United States but commonly now occurring in sporadic cases and as small contact and carrier epidemics. Steadily falling in incidence, particularly in all urban areas supplied with water of a sanitary quality and pasteurized milk, and where human faecal waste is disposed of without polluting water supplies, food, or surface of the soil. 9. Methods of control: A. The infected individual, contacts, and environment 1. Recognition of the disease and reporting: Clinical symptoms con- firmed by specific agglutination test and bacteriological exam- ination of blood, bowel discharges, or urine. 2. Isolation: In fly-proof room, preferably under hospital conditions, of such cases as cannot command adequate sanitary environment and nursing care in their homes. Release from isolation should be determined by two successive negative cultures of stool and urine specimens collected not less than 24 hours apart. 3. Concurrent disinfection: Disinfection of all bowel and urinary discharges and articles soiled with them. 4. Terminal disinfection: Cleaning. 5. Quarantine: None. 6. Immunization: Of susceptibles in the family or household of the patient who have been exposed or may be exposed during the course of the disease. 7. Investigation of source of infection: The actual or probable source of infection of every case should be determined by searching for common and individual sources: 1. Polluted water, milk, shell- fish, and other food supplies; 2. Unreported cases and carriers. HYGIENE AND SANITATION 407 B. General measures: 1. Protection and purification of public water supplies. 2. Pasteurization of public milk supplies. 3. Limitation of collection and marketing of shellfish to those from approved sources. 4. Sanitary disposal of human excreta. 5. Supervision of other food supplies, and of food handlers. 6. Prevention of fly breeding. 7. Extension of immunization by vaccination to persons subject to unusual exposure by reason of occupation or travel, to those living in areas of high endemic incidence of typhoid fever and to those for whom the procedure can be systematically and eco- nomically applied, as in the military forces and institutional populations. 8. Discovery and supervision of such typhoid carriers, and their ex- clusion from the handling of foods, as epidemiological and bac- teriological evidence indicate are of importance. 9. Exclusion of suspected milk supplies on epidemiological evidence pending discovery and elimination of the cause of contamination of the milk. 10. Exclusion of suspected water supply, until adequate protection or purification is provided unless all water used for toilet, cooking, and drinking purposes is boiled before use. 11. Education of the general public and particularly of food handlers, concerning the sources of infection, and modes of transmission of the disease. 12. Instruction of convalescents and chronic carriers in personal hy- giene, particularly as to sanitary disposal of faecal waste, and handwashing after use of toilet, and restraint from acting as food handlers. GROUP III. DISEASES TRANSMITTED BY INSECTS. AND OTHER ARTHROPODS Dengue. Malaria. Plague. Typhus fever. Yellow fever. Others, not here discussed : Filariasis. Others, not here discussed—Continued. Leishmaniasis. Relapsing fever. Rocky Mountain fever. Trench fever. Tsutugamuchi fever. Tularaemia. Dengue. 1. Recognition of the disease.—An acute febrile infection of sharp onset with two paroxysms, of short duration. Intense headache, joint and muscle pains, and irregular eruption are usual. 2. Etiological agent.—A specific filtrable virus. 3. Source of infection.—The blood of infected persons, during first 3 days of the disease. 4. Mode of transmission.—By the bite of infected mosquitoes, Aedes cegypti, from 11 days after biting a patient during the first 5 days of the disease, until the death of the mosquito. 5. Incubation period.—Three to 10 days. 6. Period of communicability.—From the day before onset to the fifth day of the disease. Degree of communicability depends on prevalence of infected humans and abundance of Aedes cegypti mosquitoes. 408 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVA 7. Susceptibility and immunity.—'Susceptibility apparently universal. Acquired immunity may last a few months to a year. After several attacks an almost complete immunity is developed. 8. Prevalence.—Occurs only where the Aedes a’.gypti mosquito exists, mainly in tropics and subtropics. When occurring in epidemic form in the United States, begins usually in southernmost States, moving north until the range of the vector mosquito is stopped by climate or the season of the year. Common, and in frequent epidemics, in the Philippines. Occurs equally among males and females; less among indigenous than among visiting or transient whites where the disease commonly occurs. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting. 2. Isolation; The patient must be kept in a screened room. 3. Concurrent disinfection: None. 4. Terminal disinfection: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Search for unreported or un- diagnosed cases and for the Aedes cegypti mosquito and its breeding places. H. General measures: Measures directed toward elimination of mosquitoes (Aedes cegypti). Screening of rooms. Malaria. 1. Recognition of the disease.—A group of specific infectious fevers due to in- vasion of the red blood cells by 1 of at least 3 types of Sporozoa of the genus Plasmodium. These fevers occur endemically or epidemically and are associated with a symptom complex fairly characteristic of each variety, marked particularly by periodicity of fever and symptoms due to the growth and development of the organism. Enlargement of the spleen, secondary anaemia, and the characteristic recurrence of chills and fever as clinical findings are confirmed by observing presence of the malaria para- sites in blood film on microscopic examination. Mosquitoes of anopheline family are the only known vectors. 2. Etiological agent.—The several species of microorganisms: Plasmodium vivax, causing benign tertian malaria, Plasmodium falciparum, causing malignant tertian (wstivo-autumnal) malaria, and Plasmodium malariae (causing quartan malaria). 3. Source of infection.—The blood of an infected individual. 4. Mode of transmission.—By the bite of infected Anopheles mosquitoes. The mosquito is infected by biting an individual suffering from acute or chronic malaria. The parasite develops in the body of the mosquito for from 10 to 14 days (21 days for quartan), after which time the sporozoites appear in its salivary glands. 5. Incubation period.—Varies with the type of species of infecting microorganism and the amount of infection, usually 14 days in the tertian variety. 6. Period of communicability.—As long as the sexual form of the malaria micro- organism exists in the circulating blood in sufficient quantities to infect mosquitoes. In untreated cases this may last for months. 7. Susceptibility and immunity.—Susceptibility is universal. Negroes appear to suffer less severely from the disease. Some relative immunity appears to follow repeated attacks of the disease. A state of good nutrition is be- HYGIENE AND SANITATION 409 lieved to be a factor in maintaining resistance to the disease and in spontaneous recovery. 8. Prevalence.—Endemic and sporadic, occurring more frequently among chil- dren than adults, and more among Negroes than among whites. Particular- ly prevalent in the southeast coastal plain, Mississippi Valley, south of St. Louis, in eastern Texas, New Mexico, Louisiana, Arkansas, southern Mis- souri, and slightly in California and Oregon. Serious in Puerto Rico and the Philippines. Seasonal occurrence of tertian type in early summer, sestivo-autumnal in early fall. 9. Methods of control: A. The infected individual, contacts and environment: 1. Recognition of the disease and reporting: Clinical symptoms, al- ways to be confirmed by microscopical examinatipn of the blood. Repeated examination of blood films may be necessary. 2. Isolation: The individual with malarial parasites in his blood should be protected from the bites of ‘mosquitoes. With the exception of this simple precaution, isolation and quarantine are of no avail. 3. Concurrent disinfection; None. Destruction of Anopheles mos- quitoes in the sick room. 4. Terminal disinfection: Destruction of Anopheles mosquitoes in the sick room 5. Quarantine: None. 6. Immunization: None. The administration of prophylactic doses of quinine should be insisted on for those constantly exposed to infection and unable to protect themselves against Anopheles mosquitoes. This is not in an exact sense prophylaxis but early therapeusis. 7. Specific therapy: Quinine bisulfate is preferred for routine treatment and “atebrin” is found by some to be equally reliable. Plasmochin seems to be specific for destruction of the adult sexual form of the parasite in sestivo-autumnal malaria and in conjunction with quinine for tertian and quartan infections. 8. Investigation of source of infection: Breeding places and house infestation by Anopheles mosquitoes should be sought for and larvse and mosquitoes destroyed when and where possible. Car- riers of the malarial microorganism, untreated, or inadequately treated, should be sought and brought under systematic therapy until the microorganism can no longdr be found in their blood. B. General measures. 1. Employment of known measures for destroying larvse of anophe- lines and the eradication of breeding places of such mosquitoes. 2. Blood examination of persons living in infected centers to deter- mine the incidence of infection. 3. Screening sleeping and living quarters: use of mosquito nets. 4. Killing mosquitoes in living quarters. 5. Education of the public as to the mode of spread and methods of prevention of malaria. ' Plague (bubonic, septicasmic, pneumonic). 1. Recognition of the disease.—An acute infection running a rapid, severe course, often terminating fatally, and characterized by extreme weakness, high fever, buboes, severe general symptoms, and often accompanied by 410 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY subcutaneous haemorrhage and pustules. The infecting microorganism is regularly found in the buboes and skin lesions, and in the pneumonic type of the disease in the sputum. Pneumonic plague gives the picture of a virulent septic pneumonia. 2. Etiological agent.—Pasturella pestis (Bacillus pestis). 3. Source of infection.—Blood of infected rodents and, in the pneumonic form, the sputum of human cases. The primary or indigenous source of the disease is the so-called “wild-plague”, the animal reservoir among such rodents as the tarbigan of Manchuria, and the ground squirrel of Califor- nia. Infection may reach man from these sources, or more often through the medium of the rat. 4. Mode of transmission.—Direct, in the penumonic form. In other forms the disease is generally transmitted by the bites of fleas (Xenopsylla cheopis and Ceratophyllus fasciatus), by which the disease is carried from rats to man, also by fleas from other rodents. Accidental, by inoculation. 5. Incubation period.—Commonly from 3 to 7 days, although occasionally pro- longed to 8 or even 14 days. 6. Period of communicability.—Pneumonic type intensely communicable during acute symptoms. Bubonic type not communicable from person to person. 7. Susceptibility and immunity.—Susceptibility is general, particuarly to the pneumonic form. Natural immunity may exist but is rare. Lasting im- munity almost always results from recovery from an attack of the disease. Artificial passive immunity of about 3 to 4 weeks’ duration by antiplague serum, and active immunity of about 6 months’ duration by vaccines may be relied upon. 8. Prevalence.—Very rare in North America and insular possessions, and only sporadic cases, from exposure to infection to ground squirrels in California. Endemic in ground squirrels in large areas on Pacific Coast. Occasionally found in rats trapped at seaports. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms, con- firmed by bacteriological examination of blood, pus from glan- dular lesions, or sputum. Animal inoculation of material from suspected cases. 2. Isolation: Patient in hospital if practicable; if not, in a screened room which is free from vermin.3 3. Concurrent disinfection: Sputum and articles soiled therewith, in pneumonic type of the disease. 4. Terminal disinfection: Thorough cleaning followed by fumigation to destroy rats and fleas. 5. Quarantine: Contacts of pneumonic cases for 7 days. 6. Immunization: Ordinarily not practicable. 7. Investigation of source of infection: Search for human (in pneu- monic) and rodent (in bubonic) sources to which patient is known to have been exposed, among wild rodents, and particu- larly the rat. 3 In plague pneumonia, personal prophylaxis to avoid droplet infection must be carried out by persons who come in contact with the sick. Masks of closely woven cloth with mica windows should be worn over the head and to the- shoulders. A long gown and rubber gloves drawn over the sleeves of the gown should be provided. These articles should not be removed from the sick room until disinfected. 411 HYGIENE AND SANITATION 411 B. General measures: 1. Extermination of rats and vermin by use of known methods for their destruction; destruction of rats on ships arriving from infected ports; examination of rats, ground squirrels, etc., in areas where the infection persists, for evidence of endemic or epidemic prevalence of the disease among them. 2. Rat-proofing of buildings and elimination of breeding places and opportunities for the harboring and feeding of rats as a funda- mental sanitary measure. 3. Investigation of all deaths during epidemics with autopsy and laboratory examination when indicated. 4. Handling of corpse under antiseptic precautions. Typhus fever. 1. Recognition of the disease.—Whether in the classical and severe epidemic form of the louse-transmitted disease or in the mild flea-borne and sporadic type, the onset is variable, often being sudden and marked by headache, chills, fever, and general pains, and a macular eruption on the fifth or sixth day, toxaemia, and a quite definite course terminating in rapid lysis after 12 to 21 days. A positive Weil-Felix reaction is valuable as con- firmation of the diagnosis. 2. Etiological agent.—Rickettsia prowazeki, Rickettsia quintana, and provision- ally, Rickettsia mooseri. 3. Source of infection.—The only known source is the blood of infected persons or infected rats. 4. Mode of transmission.—The infectious agent is transmitted from man to man by lice (Pediculus humanus var. corporis) and from rat to rat or man by fleas (Xenopsylla cheopis). 5. Incubation period.—From 5 to 20 days, most often 12 days. 6. Period of communicability.—In the presence of lice, highly communicable until 36 hours have elapsed after the temperature reaches normal. 7. Susceptibility and immunity.—Susceptibility is general. One attack confers immunity, which is not always permanent. 8. Prevalence.—Widespread. Flea-borne typhus predominantly in late sum- mer and fall; louse-borne predominantly in winter and spring. The case fatality of flea-borne typhus is 2 per cent, and of louse-borne typhus 20 to 40 per cent. 9. Methods of control: A. The infected individual, contacts and environment: 1. Recognition of the disease and reporting: Cases should be promptly reported to the health authorities. 2. Isolation: In a vermin-free room. 3. Concurrent disinfection: Destroy all lice and louse eggs on the clothing or in the hair of the patient. 4. Terminal disinfection: None. 5. Quarantine: In the presence of lice, exposed susceptibles should be quarantined for 14 days after last exposure. 6. Immunization: Methods not yet available for general application. 7. Investigation of source of infection: Particular attention should be paid to patient’s contact with rats, and with louse-infected persons or clothing. R. General measures: The elimination of rats. C. Epidemic measures: Delousing of persons, clothing, and premises. 154294°—39 27 412 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Yellow fever. 1. Recognition of the disease.—Clinical diagnosis usually rests upon sudden onset, fever, prostration, slow pulse in relation to body temperature, severe headache and backache, congestion of mucous membranes, black vomit, bleeding gums, and late jaundice, with brief duration of illness. Pro- nounced albuminuria and leucopenia are characteristic. A history of possi- ble bites of infected mosquitoes is corroborative but absence of such or even failure to find Aedes cegypti mosquitoes in the vicinity does not necessarily exclude the diagnosis. Almost symptomless and certainly un- recognizable cases of this infection occur among Negro races in Africa. 2. Etiological agent.—A specific filtrable virus. 3. Source of infection.—The blood of infected persons. 4. Mode of transmission.—By the bite of infected Aedes cegypti mosquitoes, and of a few allied species. (It is not yet certain that some other suctorial insect may not be capable of acting as the transmitter.) 5. Incubation period.—Three to six days, rarely longer. 6. Period of communicability.—First 3 days of the fever, possibly 4. High degree of communicability where infected mosquitoes abound and there are many susceptible persons. 7. Susceptibility and immunity—Recovery from an attack of the disease is regularly followed by immunity, apparently for life. There is no natural immunity. Artificial immunity may be developed by the use of con- valescent serum. The duration of this is brief. Artificial active immunity may be developed by the use of modified living virus and human immune serum. The duration of this is uncertain but it apparently lasts for sev- eral years. 8. Prevalence.—Very rare in North America and insular possessions. Not known in the Pacific Basin.- No case in North America or Puerto Rico for many years. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms. 2. Isolation: Isolate from mosquitoes in a special hospital ward or thoroughly screened room. It is necessary that the room or ward should be freed from mosquitoes by fumigation, trap- ping, or highly responsible collection and destruction of the insects. Isolation necessary only for the first 4 days of the fever. 3. Concurrent disinfection: None. 4. Terminal disinfection: None, except for the purpose of destroying mosquitoes in the house occupied by the patient and in the nearest neighboring dwellings, usually best by gaseous fumigation. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Human carriers are not known to exist. Search for undiscovered mild and unreported cases of illness resembling yellow fever, and systematic testing of immunity in groups related in time and proximity to the case in question are of epidemiological importance. Search for the Aedes cegypti mosquito and other species believed to be capable of transmitting the infection should be particularly 413 HYGIENE AND SANITATION thorough in the vicinity of places of residence, work, or travel of known cases of the disease. B. General measures: 1. Eliminate breeding of Aedes cegypti mosquito throughout the community by organized service of inspection and sanitary control. 2. An inspection service for discovery of those ill with the disease is desirable whether the disease occurs in the classical, mild, or atypical form. GROUP IV. DISEASES TRANSMITTED BY DIRECT CONTACT Scabies. Venereal diseases. Ring worm. Others, not discussed here : Impetigo contagiosa. Yaws. Scabies (itch). 1. Recognition of the disease.—Observation of the characteristic interdigital burrows of the itch mite, its identification under a hand lens, or of the eggs scraped from the burrows. 2. Etiological agent.—Sarcoptes scabiei, the itch mite. 3. Source of infestation.—Persons harboring the itch mite on their skin in burrows, particularly between the fingers. 4. Mode of transmission.—Direct contact with infested persons and indirectly by use of underclothing, gloves, bedding, etc., of such persons. 5. Incubation period.—Merely the length of time for the itch mite to burrow under the skin and lay eggs and start the itching and scratching, all of which may occur within 24 to 48 hours of original infestation. 6. Period of communicability.—Until the itch mites and the eggs are destroyed. 7. Susceptibility and immunity.—These terms are not appropriate to this con- dition. Anyone may become infested and immediately reinfested. 8. Prevalence.—Wide-spread and occurring sporadically and in epidemics, es- pecially where there is a low level of bodily cleanliness and neglect of personal and clothing hygiene. 9. Methods of control: A. The infested individual, contacts, and environment: 1. Recognition of the disease and reporting; The condition should be reported to the school authorities if discovered in school children. 2. Isolation: Children should be excluded from school until disin- fested. Persons should be denied common recreation and bath- ing facilities while infested. 3. Concurrent disinfestation: Care of body clothing and bedding until free from the infestation. 4. Terminal disinfestation: Underclothing and bed covering to be so treated by dry heat or washing as to destroy the mite and the eggs. 5. Quarantine: None. 6. Investigation of source of infestation: Search for unreported or unrecognized cases in companions or house or family mates of the infested individual. B. General measures: Cleanliness of body and underclothing and bed cover- ing especially. 414 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Chancroid. 1. Infectious agent: Haemophilus ducreyii (Bacillus of chancroid). 2. Source of infection: Pus and secretion from the chancroid itself. 3. Mode of transmission■: By direct contact with infected persons. Almost invariably through sexual intercourse. Possibly in other ways. Indirectly as mentioned under syphilis. 4. Incubation period: Usually within 5 days; always within 10 days. 5. Period of communicability: During continuance of specific organism and lesion. 6. Method of control: (A) The infected individual and his environment—Same as for syphilis. (B) General measures—Same as for syphilis. Gonorrhoea. 1. Recognition of the disease.—Occurring initially as an infection of one of the mucous membranes, most frequently of the genital tract, urethra in the male, the vaginal or uterine mucosa in the female, the disease develops as an acute or chronic process in adjacent or remote tissues, among the latter especially as arthritis and endocarditis. Relapsing and chronic inflamma- tory discharging condition at the site of original attack are common. Demonstration of the etiological agent in the lesions or discharges is the best and only certain diagnostic procedure. Specific antibodies may he demonstrated, and specific constitutional and local reactions can be provoked. 2. Etiological agent.—Neisseria gonorrhoea (Gonococcus). 3. Source of infection.—Discharges from lesions of inflamed mucous membranes and glands of infected persons, viz., urethral, vaginal, cervical, conjunctival mucous membranes, and Bartholin’s or Skene’s glands in the female and Cowper’s and the prostate glands in the male. 4. Mode of transmission.—By direct personal contact with infected persons and indirectly by contact with articles freshly soiled with the discharges of such persons. In adults by sexual intercourse; in children by other per- sonal and indirect contact with discharges. 5. Incubation period.—One to 8 days, usually 3 to 5 days. 6. Period of communicability.—As long as the gonococcus persists in any of the discharges, whether the infection be an old or a recent one. Readily com- municated in sexual intercourse. 7. Susceptibility and immunity.—Susceptibility appears to he general, particu- larly of vaginal tract in young girls, and of conjunctiva in newborn. Ac- quired immunity does not occur generally, but some degree of transient local immunity may appear during infection. One attack and recovery does not protect against subsequent infection. 8. Prevalence.—Wide-spread in both sexes and at all ages, but most common among men from 18 to 40 years of age and among women at a little earlier age. Endemic, sporadic, and epidemic. 9. Method of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting; Clinical symptoms, con- firmed by bacteriological examination or serum reaction. 2. Isolation: When the lesions are in the genito-urinary tract, exclu- sion from sexual contact, and when the lesions are conjunctival exclusion from school or contact with children, as long as the discharges contain the gonococcus. HYGIENE AND SANITATION 415 3. Concurrent disinfection; Discharges from lesions and articles soiled therewith. 4. Terminal disinfection: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Each acute case should be traced to probable source of infection and appropriate control and treatment of this spreader of disease instituted. Males may continue to be carriers for a year or more; females for 2 to 3 years. B. General measures; 1. Provision of accurate and early diagnosis, and careful treatment of infected persons, with due consideration for privacy of record, consistent with effective control of the patient, search for source of infection, and provision for following cases until cured. 2. Education in matters of sexual hygiene, particularly as to the fact that continence in both sexes at all ages is compatible with health and normal development. 3. Repression of commercialized prostitution, and associated use of alcoholic beverages, by police or other competent authority. 4. Restriction of advertising of services or medicines for the self treatment of sex diseases, etc. 5. Elimination of common towels and toilet articles from public places. 6. Use of prophylactic silver solution in the eyes of the newborn. 7. Personal prophylaxis should be advised to those who expose them- selves to opportunity for infection, and made available for use immediately after sexual intercourse. 8. Exclusion of persons in the communicable stage of the disease from occupations involving contact with children. Lymphogranuloma venereum (inguinale) and Climatic bubo. 1. Recognition of the disease.—Adenopathy, inguinal in male, pelvic in female, and history of exposure to venereal infection in tropics (climatic bubo) or in temperate climates. Natural infection limited to human beings, but experimentally transmissible to monkeys and mice, less readily to other species. Characterized by small herpetiform lesion of inoculation on exter- nal genitalia or uterine mouth (rarely in it), often transitory, followed by subacute or chronic adenitis and periadenitis, usually with multiple foci of suppuration; associated with constitutional symptoms, fever, prostration, loss of weight, rheumatic affections, and skin reactions. Clinical diagnosis may be confirmed by Frei antigen intradermal test. 2. Etiological agent.—A specific filtrable virus. 3. Source of infection.—Discharges from lesions. 4. Mode of transmission.—Direct contact by skin and mucous membranes, almost exclusively in sexual relations with infected persons, or indirectly by articles soiled with discharges from the lesions of such persons. 5. Incubation period.—One to four weeks. Glandular enlargement follows the initial lesion in 1 or 2 weeks. 6. Period of communicability.—As long as there are open lesions upon skin or mucous membranes. 7. Susceptibility and immunity.—Susceptibility appears to be general. Immu- nity apparently does not follow an attack of the disease. There is no artificial immunity. 416 HANDBOOK OF THE HOSPITAL COUPS, H. S. NAVY 8. Prevalence.—Has been known for many years as an occasional venereal infection in the Negro quarters of cities in the United States and more commonly in tropical possessions. Is still a rare disease in northern cities and among whites. Widely prevalent in the tropics and common among inmates and clients of brothels in tropical seaports. 2. Methods of control: A. The infected individual, contacts, and environment; 1. Recognition of the disease and reporting: Clinical symptoms. 2. Isolation: Exclusion of infected person from sexual contacts and from preparation and serving of food during period of com- municability. 3. Concurrent disinfection: Discharges and articles soiled therewith. 4. Terminal disinfection: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Search should be made for case of origin, particularly among prostitutes and among persons of Negro race, and of former residence in tropical and subtropical areas. B. General measures: 1. Education in matters of sexual hygiene, particularly as to the fact that continence in both sexes and at all ages is compatible with health and normal development. 2. Repression of commercial prostitution and associated use of alco- holic beverages by use of police and other competent authority and control of living premises. 3. Elimination of the use of common towels, cups, toilet articles, and eating utensils. 4. Exclusion of persons in the communicable state of the disease from participation in the preparing and serving of food. 5. Personal prophylaxis should be advised and made available for use immediately after sexual intercourse to those who expose themselves to opportunity to infection. Syphilis. 1. Recognition of the disease.—A disease acquired by contact or transmission in utero, running a chronic course with local and constitutional manifesta- tions, usually in a definite sequence although of infinite variety. The lesion is an infectious granuloma, similar to that seen in tuberculosis and leprosy, in the acquired disease usually on mucous or muco-cutaneous area of sexual contact. Confirmation of diagnosis is practicable and should be established in every instance by finding the spirochsete in the lesions or discharges or by positive serological findings. 2. Etiological agent.—Treponema pallidum (Spirochceta pallida). 3. Source of infection.—Discharges from the lesions of the skin and mucous membranes, the blood of infected persons, and articles freshly soiled with such discharges or blood in which the Treponema pallidum is present. 4. Mode of transmission.—By direct personal contact with infected persons and indirectly by contact with discharges from lesions or with the blood of such persons, by sexual intercourse chiefly, by kissing, by dental and other sur- gical or technical accidents, congenitally from syphilitic mother through the placenta. 5. Incubation period.—About 3 weeks, minimum 10 days, occasionally 6 weeks or longer. HYGIENE AND SANITATION 417 6. Period of communicability.—As long as the lesions are open upon the mucous membranes or skin, but practically limited to the first 2 years of the disease. 7. Susceptibility and immunity.—Susceptibility is universal, especially when moist surfaces of infected and exposed persons are brought into direct contact. Natural or acquired immunity is not known to exist. One attack and recovery does not protect against subsequent infection. 8. Prevalence.—Widespread in all regions of the world, regardless of race, cli- mate, or geography, or of sex or age. Prevalence varies from less than one-half of 1 per cent to 80 per cent and over of local population groups, averaging probably about 5 per cent of all the people of North America. Occurs in sporadic, local, or group epidemic, and commonly endemic form. Most commonly acquired by unmarried males between 20 and 40 years of age. Occurs in about 10 per cent of all pregnant women. Most frequent among Negroes. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting: Clinical symptoms, con- firmed by microscopical examination of discharges and by serum reactions. Diagnosis is essentially a laboratory problem and treatment should never be instituted without laboratory con- firmation. 2. Isolation: Essential for noncooperative patients at least until sur- face lesions have healed. No person in the communicable stage of syphilis should be permitted to engage in occupations of personal service in which he or she may infect others with syph- ilis, such as those of nurse or nursemaid, domestic servant, bar- ber, hairdresser, chiropodist, manicurist, bath attendant, mas- seur, wet nurse. Sexual intercourse should be specifially warned against and so far as possible prevented for persons with syphilis until declared to be free from infection by the physician respon- sible for treatment of the patient. 3. Concurrent disinfection of discharges and of articles soiled there- with. 4. Terminal disinfection: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Bach case, particularly those cases of presumably recent origin, as the congenital form of the disease in infants, and first and second-stage cases of the ac- quired disease, should be traced to the probable source of infec- tion, appropriate control and treatment of this spreader of disease instituted, and further exposed contacts examined for unsuspected or unreported cases. B. General measures: 1. Provisions for accurate and early diagnosis and careful treat- ment of infected persons, with due consideration for privacy of record, consistent with effective control of the patient, search for source of infection, and provision for following cases until cured. 2. Education in matters of sexual hygiene, particularly as to the fact that continence in both sexes and at all ages is compatible with health and normal development. 418 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 3. Repression of commercial prostitution and associated use of alco- holic beverages, by means of the police or other competent authority. 4. Restriction of advertising of services or medicines for self- treatment of sex diseases, etc. 5. Elimination of the use of common towels, cups, and toilet articles from public places. 6. Serological as well as clinical examination for syphilis should be part of the routine prenatal supervision of the expectant mother and if she is found to be infected, antisyphilitic treatment should he begun if possible before the end of the fifth month of preg- nancy. 7. Personal prophylaxis should be advised and be made available for use immediately after sexual intercourse to those who expose themselves to infection. Ringworm. (Of scalp, body, feet, and groin.) 1. Recognition of the disease.—Inspection of the scalp and other parts of Ihe body for the characteristics of the local lesion. Identification of the fungus in the scrapings from the edges of the skin areas involved. 2. Etiological agent.—Trichophyton, or epidermophyton. 3. Source of infection.—Lesions on bodies of infected persons or articles of clothing carrying the fungus or its spores. 4. Mode of transmission.—Direct skin-to-skin contact with lesions of infected persons and indirectly by articles of wearing apparel or by surfaces con- taminated by scurf or scalings or hair from lesions. 5. Incubation period.—Undetermined. 6. Period of communicability.—As long as the fungus or its spores can be found at the site of the lesions. Transmission is easy in ordinary conduct of home or recreational pursuits, particularly those carried out indoors. 7. Susceptibility and immunity.—Susceptibility general. There is relative immunity to scalp ringworm after 15 years of age. 8. Prevalence.—Wide spread, varying with aggregation of people under condi- tions appropriate for spread, as at swimming pools. Foot ringworm more common in adults, and the body, face, and head form more so among children, more especially in warm weather. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of disease and reporting: All cases recognized on inspection of school children should be reported to school authorities. 2. Isolation: Children and adults with marked cases of the disease should be excluded from privileges in gymnasium and at swim- ming pools. Exclusion from school may be desirable in cases of ringworm of the scalp. There are too many carriers of foot ringworm to make control of them at all practicable. 3. Concurrent disinfection: Cleanliness of body and underclothing, especially socks 4. Terminal disinfection: None. 5. Quarantine: None. 6. Immunization: None. 7. Investigation of source of infection: Among school children medi- cal inspection should be used to detect unreported cases. In gym- nasia and buildings devoted to athletics, particularly swimming, 419 HYGIENE AND SANITATION search should be made as a routine, to exclude cases from common facilities. B. General measures: 1. Cleanliness of body and underclothing. 2. Prompt and persistent treatment of the lesions should be urged. 3. Protection of feet against contamination in showers and dressing rooms and areas used by people with bare feet. 4. The use of disinfecting solutions may prove useful in connection with common bathing and dressing rooms. GROUP V. DISEASES OF LOWER ANIMALS WHICH MAY BE TRANS- MITTED TO MAN Rabies. Trichinosis. Others, not here discussed ; Actinomycosis. Anthrax. Others, not here discussed—Continued. Foot and mouth disease. Glanders. Malta fever. Tularsemia. Rabies. 1. Recognition of the disease.—In the human being this acute, specific, rapidly fatal infection may not be recognized until a spasm of deglutition appears, unless the earlier and mild constitutional symptoms such as an expression of anxiety, paresthesias especially in or near the wound, and some paralysis have been looked for after the bite of a rabid animal. In the dog or other animal, recognizable symptoms are any unexplained change in behavior followed by excitability or paralysis, and death within 10 days of onset of symptoms. Verification of cause of death may be established by discovery of Negri bodies in nerve cells of brain or cord, or by animal inoculation. 2. Etiological agent.—A specific flltrable virus. 8. Source of infection.—Saliva of infected animals, chiefly dogs. 4. Mode of transmission.—Inoculation of denuded tissue with saliva of infected animals, almost always by bites. 5. Incubation period.—Usually 2 to 6 weeks. May be prolonged to 6 months or even longer. Duration depends on virulence of saliva and on site of wound in relation to richness of nerve supply and directness of nerve path to brain. 6. Period of communicability.—For 15 days in the dog before the onset of clinical symptoms and throughout the clinical course of the disease. Only slightly communicable in man. 7. Susceptibility and immunity.—Susceptibility general. Natural immunity is not known to exist in man or among the animals subject to the disease. Prophylactic antirabic treatment of infected humans will prevent develop- ment of the disease, with rare exceptions, if the treatment is begun soon after the injury and the site of the wound is not extensive in the distri- bution of the facial nerve. 8. Prevalence.—Rare in man; more likely to occur in males than females and most often in persons under 20 years of age. World-wide distribution. Universally fatal in developed human cases. More prevalent among dogs and sometimes in wild carnivorous animals. 9. Methods of control: A. The infected individual, contacts, and environment: 1. Recognition of the disease and reporting; Clinical symptoms, con- firmed by the presence of Negri bodies in the brain of the 420 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY animal which has caused the injury, and by animal inoculations with material from the brain of such animal. 2. Isolation: None if the patient is under adequate medical super- vision, and the immediate attendants are warned of possibility of inoculation by human virus. 3. Concurrent disinfection: Saliva of patient and articles soiled there- with. 4. Terminal disinfection: Thorough cleaning. 5. Quarantine: None. 6. Immunization: Preventive vaccination of the patient after ex- posure to infection by inoculation. 7. Investigation of source of infection: Search for the rabid animal and for any animals bitten by it. Carriers in animals are not known to occur. B. General measures: 1. Detention and examination of dogs suspected of having rabies. 2. Immediate antirabic treatment of people bitten by dogs or by other animals suspected or known to have rabies, unless the animal is proved not to be rabid by subsequent observation or by microscopic examination of the brain and cord. The wound caused by any bite of a rabid animal should be treated at once to the depths with fuming nitric acid, with complete protection of the eye in the case of face bites. 3. Education in the care of dogs, especially directed to dog owners and the police, including advice against shooting of rabid or suspected animals in the head lest the laboratory examination of the brain be rendered difficult or impossible. Dog owners should be impressed wuth the serious implications of keeping dogs in densely built up cities. 4. Control of dog population by requiring animal license, provision for the impounding and the humane destruction of all unli- censed dogs, quarantine of all dogs in areas wffiere rabid ani- mals have run at large. Trichinosis. 1. Recognition of the disease.—In human beings confined to persons who have eaten raw7 or insufficiently cooked fresh pork products, occasionally bear meat, and characterized by onset of variable intensity according to the amount of infested meat eaten and the abundance of the trichinae in the meat. The symptoms of invasion may be mild or of severe gastro-intestinal disturbance. Muscle soreness or pain, oedema of face and eyelids, weak- ness and distress are accompanied by a marked eosinophilia. Microscopic examination of the stools for adult werrns, and of teased specimen of deltoid muscle for suspected embryos is helpful. Occasionally examination of the uncooked pork will reveal the parasites, 2. Etiological agent.—Trichinella spiralis {Trichina spiralis). 3. Source of infection.—Uncooked or insufficiently cooked pork, rarely meat of other animals. 4. Mode of transmission.—Direct from meat to man through consumption of undercooked infected pork products. 5. Incubation period.—Variable; usually about 1 week. eds are filled with coarse sand over a layer of gravel. The sewage, without any preliminary treatment other than being passed through screening and grit chambers, is flowed onto the beds. The purifying action is due to oxidation, both aerobic and anaerobic bacteria, animal and vege- table life, and filtration. The beds must be allowed to rest intermittently to permit the breaking down and oxidation of the material which otherwise would clog them. The activated sludge process consists of aeration of sewage in tanks in contact with sludge from previously aerated sewage. The air is introduced from the bottom, produces greater oxidation, and also permits increased aerobic bacterial action. In the sterilization of sewage liquid chlorine is used as in water purification. It is most effective when mixed with the effluent from the purification processes and is applied to insure the death of practically all the microorganisms. In the dry system of sewage disposal faecal and urinary matters are re- ceived in pails or water-tight receptacles, which are regularly replaced by empty sterilized containers. This system, also known as the bucket system, is suitable for isolated houses or small groups of houses and for temporary camps where the natural drainage is into the public water supply or where there is HYGIENE AND SANITATION 445 insufficient water available for the water-carriage system. It is frequently used in military operations and has the advantage of immediate availability. The safety of the system depends upon proper care by the user and the collector—cleanliness in handling, prompt and frequent collection, disinfection of receptacles, protection of faecal material from flies, and final incineration or burial in a suitable locality or discharge into sewers. Aboard ships at sea the dry refuse, such as paper, boxes, etc., is burned in the fire boxes of the boilers on coal-burning ships or in incinerators on modern ships. Tin cans are punctured and thrown overboard. Wet garbage is dis- charged over the side through slop chutes. In port, trash, garbage, and ashes have to be disposed of in lighters provided for those purposes. In navy yards, bins and containers are provided by the yard authorities and the refuse removed by them. Scrupulous cleanliness should be observed with garbage and trash containers to avoid unpleasant odors and attracting flies and rodents. Garbage cans always should be covered tightly. Refuse ashore is generally estimated at one ton per person per year. It varies according to season and community. Methods of collection and disposal are as follows: Collection Methods. 1. Separate method, in which wet garbage is placed in one container, trash in another, and sometimes ashes in an- other. 2. Mixed collection, in which all wastes are placed in one container, the dry mat- ters absorbing the excess liquid. Disposal Methods. Garbage is fed to hogs or subjected to reduction. In the latter case, the garbage is boiled in cookers, the fat skimmed off and sold for making soaps, candles, etc.; the tankage remaining in the cookers is dried and sold for making fertilizers. Ashes and noncombustible materials are used for filling. Incinerated or used for filling purposes. Clothing. The chief purposes of clothing are to maintain the temperature of the body, to hinder as little as possible the body’s heat regulating mechanism by per- mitting evaporation from the skin, to afford free movement of the body, and to protect the body from injury by heat, cold, wind, rain, snow, etc. Clothing is derived chiefly from the animal kingdom, which jirovides wool, leather, fur, and silk, and the vegetable kingdom which provides cotton, linen, rubber, paper, and other fibers. The structure of the principal clothing fibers is as follows: Wool fiber is large and is made up of scales of hairs overlapping like shingles on a roof, which take up and hold moisture and large quantities of air. When spun into yarn from which cloth is woven it enmeshes greater quantities of air. Cotton fiber is flat and twisted spirally. Cotton thread is compact and contains prac- tically no air. Silk fiber is a small, smooth tube. Linen fiber is cylindrical with cross lines indicating division of cells. The value of material used for clothing depends upon its action in relation to the amount of air enmeshed in its fibers, its action in relation to moisture, and its special adaptability to varying needs and conditions. Air is a poor conductor of heat and if much of it is contained in the meshes of clothing it makes the clothing warm. Added layers of clothing give additional layers of air and thereby decrease heat loss. Water is a good conductor of heat and if clothing material takes up moisture rapidly and also permits its rapid evaporation heat is extracted from the body too quickly and chilling results. 446 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The color of clothing has a bearing on its warmth, dark colors absorbing heat while light colors reflect away heat waves. Consequently white and light-colored garments are worn when the sun is hot, and dark-colored ones in cold weather. Wool, being the natural covering of animals, and its structure as noted before, makes the warmest garments. It is woven in such a manner as to entangle great quantities of air, which being a poor conductor of heat, prevents sudden lowering or raising of the body temperature. It takes up moisture readily, but gives it oft slowly; thus reducing the “cooling by evaporation.” When saturated with moisture, its fibers still contain much air, which also checks rapid loss of heat. A good example of the effect of these qualities is the use of woolen gar- ments by athletes and others who are exposed to cooling temperatures when wet with perspiration. Wool is very irritating to the skin, costly, wears poorly, and shrinks greatly. Leather is used for hard wear and as a wind breaker. Fur protects against the wind and cold because of the impermeability of the basic skin, and the large amount of air about the hairs. Cotton fiber and thread contain very little air, and therefore do not make warm garments. However, it can be woven so as to entangle air, as in fleece- lined underwear, flannelette, etc., which are warm and soft. It gives off moisture rapidly and contains practically no air when saturated, hence wet cotton garments are chilling. Cotton is cheap, very durable, and is used gen- erally for light, cool, summer garments and for making underwear. Linen has much the same properties as cotton, but like silk is not used in the Navy. It makes excellent tropical clothing. Paper at present has no wide adaptability for clothing purposes. It is used chiefly as a wind breaker. Its sanitary uses are increasing, however, as for towels, napkins, handkerchiefs, dishes, etc. It is cheap and when contaminated with human body discharges can readily be burned. Rubber and rubberized garments are used to protect against wet conditions. Garments can be treated with nonhygroscopic chemicals such as aluminum acetate, which causes them to shed water. This is called cravenettlng. From the foregoing it can be seen that in so far as materials and colors are concerned the Navy uniform is based on sound scientific principles. This is further enhanced by adapting the “uniform of the day” to the weather conditions as advised by the medical officer. In the tropics, the head and back of the neck should be protected from the direct rays of the sun. The relation of insects, vermin, and rodents to disease and methods for their extermination. The primary considerations in the control of insects and pests and the prevention of the diseases transmitted by them are; To prevent them from breeding, to prevent them from coming in contact with infected cases, to remove all possible sources of food supply, and to use all possible control measures constantly. Not only are mosquitoes bothersome pests, but they are responsible for the transmission of malaria, yellow fever, filariasis, and dengue fever. Patients with such diseases always should be thoroughly screened to prevent access of mosquitoes. Anopheles mosquitoes breed in semiwild conditions in swamps and bogs; the disease-transmitting Culex and Aedes varieties breed about human habitations. Neither species flies ordinarily more than half a mile; therefore control measures against the disease-transmitting mosquitoes need not extend beyond that distance from the community or camp. HYGIENE AND SANITATION 447 The development of mosquitoes may be conveniently studied in two general stages, the aquatic and the aerial stages, and control measures correlated therewith. The eggs of mosquitoes are always deposited in water and hatch in 1 to 2 days into larvae or wrigglers, which change into shrimplike bodies called pupae in about 7 days. As mosquitoes require stagnant water for breeding, the most important of control measures is to get rid of the standing water by filling up depressions or draining off the water through subsoil or open drains. Drains should be as few as possible, clean cut, with sloping edges, narrow bottoms, and straight courses; lateral drains should connect at acute angles (“fishbone”) to lessen deposits of silt. Frequent inspection and thorough upkeep of drains is necessary. If the water cannot be drained off, crude oil or kerosene or mixtures of these can be spread over the surface to suffocate the larvae and pupae which must have air to live. If the water is not to be used for humans or animals, larvacide (containing phenol) can be added to the water to kill the larvae and pupae; Paris green diluted with an inert dust also is spread over the water for this purpose. Water in cisterns, rain barrels, etc., should be screened to prevent access of mosquitoes to breed. Larvae-eating fish can be added to ponds, cisterns, etc., where oiling, larvacides, or screening are not applicable. Vegetation which slows water and forms breeding sites for mosquitoes should be cleared from the banks of streams and ditches. Tin cans should be flattened or punctured and jugs and bottles broken, etc., in order to eliminate all standing water. The aerial stage of development begins when the adult winged mosquito emerges from the pupa in 2 to 12 days, the entire metamorphosis from egg to adult requiring 9 to 12 days, according to weather conditions. Principal of control measures for adult mosquitoes is thorough and complete screening con- taining not less than 16 meshes to the square inch, preferably 20 meshes. In- secticides, such as sulfur-dioxide gas, burning pyrethrum or camphophenique, or one of the many insecticide sprays on the market are useful. Volatile or pungent liquids such as oil of citronella may be applied to the skin or clothing to repel them; the mosquitoes return, however, after the oil has evaporated. In malarial regions a valuable preventive measure is to destroy engorged Anopheles mos- quitoes attempting to escape from sleeping quarters in the morning. Thick shrubbery harbors adult mosquitoes and should be cut or burned away. Differentiation of mosquitoes and their morphological characteristics will be found under Parasitology in the section on Laboratory Procedures and Technique. Flies may transmit many diseases under the following conditions: By having access to human body discharges (fseces, urine, sputum) containing infectious microorganisms (Fig. 125) ; by having access to contagious or infectious mate- rials on the external surface of the body; and by biting and carrying infection from one person or animal to another, as in African sleeping sickness and tularaemia. The common house fly or, as it is frequently and appropriately called, the “typhoid fly,” passes through the following developmental stages: The egg hatches into the larva or “maggot” in 8 hours to 1 day; the larva changes into the pupa in 4 to' 8 days; and 3 to 5 days later the adult fly emerges from the pupa. The entire metamorphosis requires 7 to 14 days or longer, according to weather and other conditions. Flies are prolific breeders, it having been estimated that a single female fly can produce 810 pounds of flies in a single season. {See p, 543.) 448 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY The presence of flies is an indication of nearby filth, as they breed in decay- ing garbage, animal manure, and human faeces. The feet of flies have adhesive pads enabling them to adhere to very smooth surfaces, and hairs and claws by means of which they hold on to rough surfaces. Filth and microorganisms are carried about on these pads and hairs. They also possess a retractile proboscis which transmits filth. Control measures consist of preventing fly breeding by sanitary disposal of all body and other wastes, particularly manure; destruction of larvae by kero- sene, borax, incineration, etc.; and destruction of adult flies by poisons placed in sweetened water, fly paper, live steam, insecticides, and swatting, early in the season. No fly should be permitted to live in a sick room, a hospital ward, or a sick bay. Food and all body wastes should be thoroughly protected from them. FINGERS Excreta FROM Patients OR Germ Carriers Foods (milk) Vegetables Oysters MOUTHS or Persons FLIES WATER Figure 125.—Illustrating the participation of several routes of dissemination in the propa- gation of the typhoid bacillus. (U. S. Public Health Reports.) Plague is a disease of rodents transmitted from one to another and from rodents to man by the bite of the flea. Rats also are considered the reservoir of trichinosis. They are particularly bothersome in trench warfare. Rats eat every known kind of food and are prolific breeders, and therefore easily exist and multiply everywhere. The estimated annual economic loss in the United States due to rats is 1 billion dollars. The Norway or brown rat, to which many names are applied, is the most common type. It is very ferocious and drives other types away from buildings. Numerous control measures are used to prevent the spread of disease by rodents. They should be kept from human contact by rat proofing buildings, plugging up all rat holes with cement, and screening basements. Their food supply should be eliminated by protecting all food, garbage, fodder, etc. Traps of all kinds should be employed continually and baited with out-of-season foods, taking care to eliminate human odor from about the traps and to place them in rat runways, near rat holes, and out of sight. Shops and buildings should be fumigated with sulfur-dioxide, carboxide, or hydrocyanic-acid gas. Rat guards should be used on all ship’s mooring lines. Poisons may be used but are not recommended in view of other available methods and the danger of poisoning other animals and persons, especially children. To control rats it is necessary to use all possible methods all the time. HYGIENE AND SANITATION 449 While there are about 200 species of fleas, only 2 are of medical interest: Pulex irritans (the human flea) and Xenopsylla cheopis (the rat flea). As noted under rodents, the flea is responsible for the spread of plague, which transmission is purely mechanical. The eggs are laid in the cracks of floors or in loose earth. If deposited on the animal they drop oft into its flea-infested bed. The eggs develop after 2 to 14 days into the larval form, which spin silken cocoons housing the larvse, from which the adult fleas emerge in 10 to 14 days. The complete metamorphosis requires about 30 days, and if deprived of an opportunity to feed, adults die in 6 days or less. If the larvae are killed, fleas will soon disappear. Control measures consist of fumigation with sulfur-dioxide gas or hydrocyanic-acid gas which destroys them, and crude fuel oil, kerosene, or gasoline sprinkled in the nests of animals, the cracks or crevices of floors or beneath houses is effective. Posts supporting houses can be smeared with crude fuel oil. In using inflammable oils special care must be taken to avoid fire. Use the same measures for infested clothing as are used for lice. Lice transmit typhus fever, relapsing fever, and trench fever and their bites may lead directly or indirectly to secondary pathologic conditions of various kinds. There are five stages in the development of the louse requiring ordi- narily about 16 days; the nit or egg, three molting larval stages, and the adult stage. They are insatiable feeders and live on human blood, needing at least one feeding a day. They cannot live over 10 days away from the body. There are three types of human lice: Pediculus humanus var. corporis, the clothing or body louse, Pediculus humanus var. humanus, the head louse, and Phthirius pubis, the crab louse. Lice are more common in winter than in summer because of the favorable temperature for the laying of their eggs and partly because the clothing is likely to remain unchanged and bathing is less frequent. The effect of temperature on the occurrence of lice is shown by the fact that lice are prevalent in certain places in high altitudes where the climate is cool, while in certain places which are low and hot there are very few vermin- infested individuals. As lousiness results chiefly from overcrowding and insanitary conditions, the principal control measures and the best preventives of louse infestation are the maintenance of personal hygiene and of a sanitary environment. Cloth- ing infested with Pediculus humanus var. corporis can be disinfested with live steam under pressure followed by a vacuum to dry the clothes, boiling for five minutes, or immersed in 5 per cent saponated solution of cresol for 30 minutes. Kerosene also is very effective. If males are infested with Pediculus humanus var. humanus the hair should be clipped short. In the case of females, the hair should be treated with a mixture of equal parts of vinegar and kerosene; and covered with a towel for one-half hour; then washed with warm water and soap. The kerosene kills the lice and vinegar loosens the nits. For infestation with Phthirius pubis the pubic hair should be closely clipped and mild mercurial ointment or camphophenique applied. Kerosene may be used but care must be taken to prevent burning or blistering the skin. General delousing of troops or large numbers of people is carried out by having each person disrobe and their clothing bagged and turned over to attendants for steam disinfection. An inspection of the body is then made for nits, head, or crab lice. If found, the infested parts are clipped or shaved. A thorough warm shower is then taken, using liquid soap. Attendants in delousing plants should be protected from infestation by wearing vermin- proof suits. 450 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The bedbug, Cimex lectularius, is a blood-sucking insect and seeks human skin at night in order to obtain nourishment. It has been suspected of being a transmitter of many different infections but there is no convincing evidence that it is. In biting preparatory to feeding it forces an irritating substance into the skin that may cause an urticarial, petechial, or macular eruption, and its bites, if numerous, are sometimes quite painful. The bedbug lives in cracks and crevices, particularly about beds, is most numerous where there are transients, as in boarding houses, hotels, etc., and is known to migrate from house to house. The eggs are deposited in cracks and in about 10 days hatch into larva1, which pass through five moultings to adults in 2 or 3 months. Control measures in bedbug infestation require sterilization of bedding and mattresses, which is best done by steam under pressure. Ships or buildings badly infested can be fumigated with sulfur-dioxide gas or carboxide gas. For metal beds and springs the flame torch or live steam is effective. A pyrethrum spray is very efficient. A solution of 5 per cent cresol in kerosene may also be used. All liquid or powder insecticides must penetrate into the cracks where the bedbug hides and breeds to be effective. Bedding, ashore or afloat, should be aired and sunned at least twice weekly, at which time it should be examined carefully for vermin. Each piece should be shaken sepa- rately. Soothing lotions containing menthol, phenol, and camphor should be used on the skin to relieve pain. Roaches are among the commonest and most offensive of insects which infest human habitations and are under suspicion of carrying several infections, including typhoid fever and “meat” poisoning. Cockroaches are nocturnal in- sects, hiding in cracks and crevices in the presence of light. They are voracious, eating everything or rendering it useless because of peculiar odor emitted. The eggs are laid in a hard capsule which almost fills the body of the female before it is laid. The eggs hatch and pass through several molts requiring at least a year under favorable conditions before full growth is reached. The most important control measures are scrupulous cleanliness about all places (galleys, bakeries, butcher shops, storerooms, etc.) where food is handled, and preventing their access to food. All unnecessary cracks and crevices where they breed and hide should be eliminated. Repeated fumigation with carboxide gas will destroy them. The usual insecticidal sprays are effective but must be sprayed into cracks repeatedly. A concentration of 15 per cent 20-1 pyrethrum concentrate with 5 per cent Lethane 384 in deodorized kerosene is an extremely efficient spray. Sodium fluoride powder sprinkled in their runways, about shelves, closets, drawers, etc., and allowed to remain helps to control them. Disinfection and fumigation. The distinction between disinfection and fumigation must be kept clearly in mind. Disinfection properly applied is of great value in the prevention of com- municable diseases. With the destruction of infective discharges and the exer- cise of great care and cleanliness throughout the course of a communicable disease there is less need for terminal disinfection. The boiling of sheets, pa- jamas, towels and similar articles and a thorough scrubbing of the sufaces with hot water and soap, and disinfecting of bedding with steam is a more effective method of disinfection than by the use of one of the gaseous agents. Gaseous fumigation for the bacterial viruses has been discontinued as a sanitary meas- ure. Gases, such as formaldehyde, are uncertain in practice and have the merest surface action but they cannot be depended on against tuberculosis or diphtheria. Fumigation has its place in preventive medicine and is used prin- cipally for the destruction of rodents in the control of plague, the extermination HYGIENE AND SANITATION 451 of insects, especially bedbugs, and, in exceptional instances, for the extermination of mosquitoes as a disease prevention measure. The agents used in disinfection are of two types, physical and chemical. Physical agents of disinfection include sunlight, burning, boiling, and steam. Sunlight is an active germicide, due to the ultra-violet rays contained therein. Burning is of unquestioned efficiency and should be used whenever conditions permit. Incineration of wastes is practiced more extensively each year. Boiling is very effective and of wide usefulness. The articles should be com- pletely immersed for not less than 10 minutes in water actually boiling. The addition of 1 per cent of carbonate of soda renders the process applicable to polished steel and cutting instruments. Steam is one of the most satisfactory disinfecting agents. It is reliable, quick and may be depended on to penetrate deeply. It may be used as flowing steam, or steam under pressure. Flowing steam has the same disinfecting power as boiling water when the exposure is continued for 30 minutes. Steam under pressure is more power- ful as a germicide than flowing steam. After the pressure has reached 15 pounds per square inch above atmospheric pressure, the temperature is approximately 120° 0. (248° F.) and can be depended on to sterilize in 20 minutes. The air, being a poor conductor of heat, must be expelled from the apparatus at the beginning of the process. The best method of applying steam under pressure is in a special apparatus with a vacuum attachment, the object of the vacuum apparatus being to expel the air and to promote the penetration of the steam. Clothing, fabrics, textiles, curtains, hangings, etc., may be treated by either of the above methods as circumstances may demand. Cooking and eating utensils, after washing, should always be disinfected by immersion in boiling water or steam. Where dishwashing machines are used the dishes are washed for 1 minute maintaining the temperature of the wash water at not less than 160° F, throughout the washing period and rinsed for 10 seconds with the rinse-water temperature maintained at not less than 180 °F. Commonly used chemical agents of disinfection are bichloride of mercury, phenol (carbolic acid), formalin, and chlorinated lime. Bichloride of mercury is used very extensively, but as it attacks metals it can- not be used on them, and must be placed in containers of glass, china, wood, or earthenware. It coagulates albumin and therefore cannot be used to disinfect albuminous matters. It is incompatible with alkalies and their carbonates, lime water, soaps, and most metallic salts. Bischloride of mercury is used commonly in a strength of 1:1,000, adding to the water used for solution 2 parts per 1,000 of sodium or ammonium chloride. Materials to be disinfected should be immersed in that solution for at least an hour. It is used for soiled fabrics and to wash down floors and walls. Phenol (carbolic acid) is generally used in a 5 per cent solution. It is very efficient and is used to standardize disinfectants. Because of its expense many cheaper but effective derivatives are employed, chief among which is cresol, as in Liquor Cresolis Saponatus, U. S. P. (used in 1; 20 solution). Phenol or its derivatives are used to disinfect fteces, urine, sputum, spit kits, contaminated clothing or fabrics, walls and decks of compartments. Exposure should be for 1 hour. “Formalin” is a commercial solution containing not less than 37 per cent of formaldehyde gas and is used in a 5 per cent solution (commercial formalin 5 cc, water 95 cc). Exposure should be for 1 hour, and when used to disinfect liquids 452 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY or semisolids formalin should be added in sufficient amount to make a 5 per cent solution. It has a wide variety of uses and is also an excellent deodorant. Chlorinated lime, containing not less than 30 per cent available chlorine, is used as a disinfectant by adding 1 pound to 4 gallons of water. This solution is satisfactory for mopping floors and walls. For disinfecting faeces, urine, and sputum, an equal amount of the solution should be added and allowed to stand for 1 hour. The principal gaseous agents of fumigation used are hydrocyanic-acid gas, sulfur dioxide, carboxide gas, and formaldehyde. Hydrocyanic-acid gas is extremely poisonous to all forms of animal life and is the most effective and the cheapest fumigant for the destruction of rats. It does not harm textiles, foodstuffs, metals or painted surfaces. As small quantities of hydrocyanic-acid gas are rapidly fatal to man its use as an insecticide is necessarily limited. Its use requires the abandonment of the vessels for a more or less protracted time and is reasonably safe only when super- vised by experienced personnel. Fumigation by hydrocyanic-acid gas on naval vessels is authorized where in the opinion of the commanders of forces afloat, the conditions aboard ship are considered such as to make fumigation by this process necessary, and where rules of the U. S. Public Health Service require cyanide fumigation by that service before docking at a United States port. It is not a practical method to be used by hospital corpsmen. For a more detailed, discussion of cyanide fumigation refer to the Manual of the Medical Department, U. S. Navy. Sulfur dioxide is a weak germicide hut is exceedingly poisonous to mam- malian and insect life. It has feeble penetrating power resulting in an action merely upon the surface. It bleaches fabrics and materials dyed with vegetable or aniline dyes. It destroys linen and cotton goods by rotting the fibers. It attacks almost all metals and therefore machinery and metal parts should be first coated with vaseline. As compared to hydrocyanic-acid gas, sulfur dioxide is much less dangerous to man but it cannot be depended on to kill more than 65 per cent of the rats in holds and buildings laden with cargo under which rats can hide. To generate sulfur dioxide sulfur may be burned in shallow iron pots standing in pans of water, each pot containing not more than 30 pounds of sulfur. More equal distribution and better results can be obtained by distributing the sulfur in a number of small pots. The following amounts of sulfur for each 1,000 cubic feet of space are neces- sary: To kill mosquitoes and flies, 2 pounds and exposure for 1 hour; to kill lice, 4 pounds and exposure for 6 hours; to destroy rats, mice and fleas, 3 pounds and exposure for 6 hours. The time of exposure should be doubled for cargo-laden holds and well-filled storerooms and compartments. Carhoxide gas is a very effective insecticidal fumigant of low toxicity to ani- mals. Following exhaustive tests on board certain naval vessels it has been con- clusively shown that it can be applied aboard ship by naval personnel without undue hazard, and with a minimum of interference of ship’s routine or of move- ments of the vessels. When required carboxide gas should be obtained by requisition on the nearest navy yard or station, but should not be carried on board vessels as part of the regular allowance. Six pounds per 1,000 cubic feet is the required concentration for an exposure period of 3 hours for insects. HYGIENE AND SANITATION 453 The following instructions on fumigation with carboxide gas should be adhered to: 1. Open wide all locker doors, furniture drawers, file cases, etc., and remove covers from mattresses and pillows. 2. Disconnect ventilating ducts at the point of entrance to compartment, wherever practicable, and apply watertight covers. Otherwise the dampers of all terminals must be closed and the louvers plugged with damp rags or waste. 3. Seal all openings which might permit gas to escape. Utilize masking tape or a combination of greased paper and masking tape for magazine vents, voice tubes, radio leads, enunciator chain leads, non-watertight doors, natural venti- lators, etc. Close all drains in heads and bathrooms. Dog down all water- tight doors and ports. 4. Maintain circulation of air by running all fans in space or spaces to be fumigated. 5. Open-flame heaters or exposed-element-electric heaters should not be used in areas being fumigated. 6. All cylinders should be securely lashed in the upright position and grounded before discharging gas to avoid static sparks. If cylinder is standing on linoleum or other insulating deck covering, grounding may be effected through wire lashing to a bulkhead or to metal furniture which in turn is grounded to some metal structure of the ship. 7. Make sure that all personnel in the area are accounted for. When all preparation is complete and all openings to the space closed except the exit, open wide the valves of the cylinders successively, beginning with the unit farthest from the point of exit and with the nozzle directed away from the operator. 8. The area of fumigation may be opened at the end of 3 hours. Personnel wearing oxygen-rescue-breathing apparatus should be detailed to open all airports and re-establish supply and exhaust ventilation. Two hours after full ventilation has been in progress it will ordinarily be safe for personnel to enter for their normal activities. Storerooms and other poorly-ventilated spaces should not be entered until the following day. Experiments indicate that concentrations of carboxide lethal for bedbugs and cockroaches are also lethal for rodents in equivalent periods of exposure. Formaldehyde gas can be depended on to accomplish surface disinfection but it is valueless as an insecticide. It apparently does not damage fabrics, metals or most colors. The use of this gas is decreasing in public-health work and is limited chiefly to disinfection of rooms, clothing and fabrics, where deep penetration is not required. The most convenient and efficient method of producing formaldehyde gas is by pouring solution of formaldehyde on potassium permanganate or barium dioxide, allowing 500 cc of formaldehyde solution and 250 Gms. of potassium permanganate, or 250 Gms. of barium dioxide, for each 1,000 cubic feet of space. Place a glass or metal receptacle (10 times the size of the amount of formalde- hyde to be poured into it to allow for foaming) containing the permanganate or barium dioxide in a large pan containing water. Then pour the proper amount of formaldehyde from a pitcher or other wide-mouthed receptacle on the per- manganate or barium dioxide. Gas is generated in great amounts in a few seconds. Better distribution is secured by having a number of units, but care must be taken to “set off” those nearest the exit last. Exposure should be from 6 to 12 hours. 454 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Maritime quarantine. Medical officers of ships are required to comply with the quarantine laws of this and other countries. Persons exposed to any of the following diseases should be quarantined for the full period of incubation, viz., cholera, 5 days; yellow fever, 6 days; pneumonic plague, 7 days; typhus fever, 12 days; and smallpox, 14 days. Ships arriving in the United States with any of these diseases on board are quarantinable. Alien lepers are not permitted to land. Lepers, if citizens of the United States, must be handled in accordance with the local laws in force at the port of landing and are usually sent to the National Leprosarium at Carville, Louisiana. Vessels arriving at any port in the United States from a foreign port are considered to be in quarantine until they are given free pratique. Pratique is a certificate, signed by the quarantine officer, to the effect that the vessel has, in all respects, complied with the quarantine laws, and all on board are free from quarantinable diseases, or the danger of conveying the same. Radio pratique is issued United States naval vessels when a medical officer is on board provided there are no contagious diseases aboard and the vessel has come from a clean port. Naval vessels coming from infected ports must stop at quarantine. One case of plague, cholera, or yellow fever makes a port an infected one. United States Bills of Health are issued by the American consular officers at the ports of departure. They give a description of the vessel, the sanitary history of vessel, the sanitary conduct of vessel while at port, and the sanitary conditions existing in the port. A vessel coming from a foreign port to the United States should obtain a bill of health from the port official and also a United States consular bill of health in duplicate. Each country has its own particular bill of health. The United States bill of health is the only one that is of service to the vessel upon arrival in a port in the United States although several may have been obtained at the port of departure. For instance a British ship clearing from the port of Rio de Janeiro, Brazil, for the United States is required to secure three bills of health, one from the British consul, another from the Brazilian authorities, which is a clearance paper, and the third from the American consul. In case of a vessel sailing for the United States, the port of departure is the first port at which intention to sail to the United States is decided in making clearance from the port, or at which passengers or cargo destined to the United States are taken aboard. Not only must bills of health be secured from this port, but also from all intermediate ports of call until arrival at a United States port. Naval vessels departing from a port in the continental United States for a port in the Canal Zone or United States possessions are not required to procure a bill of health or port sanitary statement at such port of departure except when plague, cholera, or yellow fever exists, or typhus fever or small- pox prevails in epidemic form in the port of departure. A naval vessel departing from a port in the possessions or dependencies of the United States for a port in the Canal Zone or other United States posses- sions is required to procure a bill of health in duplicate at each port of departure. A naval vessel departing from a port in the United States for a foreign port should procure a bill of health and have it visaed by the consular or other representative of the country or countries of port of call, if such ports can be determined upon prior to sailing. A naval vessel sailing from a for- HYGIENE AND SANITATION 455 eign port to another foreign port should likewise procure and have visaed a bill of health. Guantanamo Bay, Cuba, is construed to be a foreign port and bills of health are required for a naval vessel entering or departing therefrom. Bills of health or port sanitary statements are issued in the United States ports by medical officers of the U. S. Public Health Service where available, otherwise by the collector of customs. Personal hygiene. By personal hygiene is meant any measure taken by the individual by which he can avoid disease, promote his health and strength, and enjoy their bless- ings. Such measures include the eating of the proper amount and kind of food, drinking the proper kind and amount of water, the wearing of proper clothing to suit the temperature, the breathing of wholesome air, all of which tend to heighten resistance; the avoidance of habits and practices which are liable to contract or transmit infectious diseases such as those borne by the mouth, nose, intestinal, and venereal discharges, etc.; the proper use of the eyes; etc. Cleanliness of the person and the clothing is one of the first requisites for good health. The entire body, if practicable, but at least the feet, armpits, and genitals should be bathed daily, and the exposed parts of the body, face, and neck ais often as necessary. The hair should be kept cut short, and the finger and toe nails kept trimmed and clean. Dirty bodies and dirty infected clothing are very often the cause of skin and other diseases. A moderate amount of exercise in the open air should be taken regularly. With proper exercise the elimination of waste products from the body is increased through deeper breathing, and more perspiration; the muscles and heart become better nourished by more rapid metabolism, and a better circulation improves all the other functions of the body; the digestion is improved; and resistance to certain diseases is increased. The bowel should move daily, otherwise poisonous substances are absorbed into the system. If proper food is eaten and proper exercise taken, the bowel generally will look after itself. The mental state may affect the health and a cheerful state of mind promotes and benefits all the functions of the body and vice versa. Not only is the practice of personal hygiene one of the greatest factors in the prevention of physiological diseases, but it is one of the chief aids to the sanitarian in destroying or preventing the transmission of the agents which cause the communicable diseases. Infective discharges from the respiratory tract can be readily transferred to others by promiscuous coughing, sneezing, and expectorating, or by the use in common of towels, drinking cups, and eat- ing utensils. Good personal hygiene will prevent many of the air-borne and hand-to-mouth infections. Following is a summary of the principles of personal hygiene which are adaptable to naval life. 1. Keep the body clean. Bathe the entire body, or as much of it as possible, daily. 2. Keep the hands clean. Always wash them before eating and after leaving the toilet. Keep the fingers away from the nose and mouth, and the finger nails clean and cut short. 3. Keep the feet clean and the toe nails cut short and straight across. 4. Change the underwear and socks frequently. Wear socks that are IVo or 2 sizes larger than the shoe size and shoes that have been fitted carefully. 5. Brush the teeth every morning and evening or after each meal if possible. Have the teeth examined by a dentist at least every 6 months. 456 HANDBOOK OF THE HOSPITAL CORPS, XJ. S. NAVY 6. Eat slowly a moderate amount of nutritious food regularly and drink plenty of pure water. 7. Be regular in going to the toilet for bowel actions. 8. Take a moderate amount of exercise in the open air regularly. Breathe deeply at all times. 9. Sleep in a well-ventilated place with plenty of fresh air. 10. Avoid excesses of any kind, but especially alcoholic drinks and promiscuous sexual intercourse. If exposed to venereal infection immediately use prophylaxis. 11. Avoid persons with colds or coughs and keep away from others when suffering with one. Cough and sneeze in a handkerchief. 12. Avoid unnecessary exposure to extremes of weather. Change into dry clothes as soon as possible after getting wet, and dry the wet clothing before stowing it away. Clothing wet with perspiration should be dried and, if possible, washed before being stowed away. 13. Avoid using the toilet or other personal articles of others and do not allow others to use one’s own. 14. Be cheerful. The precautions regarding the care of the hands and fingers are of particular importance for the majority of infections are taken into the body through the mouth and the hands are responsible for a large number. Likewise the principle pertaining to “colds” should be closely observed. Finally, if there is one basic law, it is to avoid excesses of any kind. VITAL STATISTICS The importance of vital statistics to the practice of preventive medicine cannot be overstated. Without the statistical method comparatively little progress would have been made in epidemiology and less toward the prevention and control of disease. Vital statistics may be defined as the branch of medical science that deals with the quantitative aspects of vital phenomena; in other words it is the book- keeping of human beings. It comprises a numerical presentation of facts relating to sickness, deaths, births, and marriages for the population (or strength) as a whole, or for specified groups or classes. Vital statistics commonly are prepared specifically for the following groups or classes: Sex, age, race and color, occupation. They may be prepared for subgroups of these; for instance, whites of the male sex, belonging to the age group, 20 to 29. Furthermore, it may be that only males of a particular occupational class are under consideration. Graphic methods for presenting statistics. Although statistics present facts for study in the form of numerals, their significance cannot be grasped always until the statistical facts have been further presented in graphic form—curves, lines, bar charts, spot-pin maps, pin charts, etc. (Figs. 126, 127, 128.) Graphic records are constantly necessary in statistical work for the fol- lowing reasons: 1. They make it possible to perceive instantly facts which otherwise might be concealed or discovered only after careful study. 2. They make it possible to place before the eye at one time, in under- standable form, information which otherwise could not be presented without long tables of figures accompanied by long and involved explanation. 3. They facilitate comparison of facts with other facts, closely correlated, remotely related, or, perhaps, as determined by study, bearing no relation whatever. HYGIENE AND SANITATION 457 INCIDENCE OF VENEREAL DISEASE, U. S. Navy, 1937. AGE IM YEARS Figure 126.—Type of arithmetical chart, VENEREAL DISEASES, RATE PER 1,000 U, 5. Navy, 192$ - 1957. GONOCOCCUS INFECTIONS PRIMARY CHANCROID SYPHILIS N MS D/V of PREVENTIVE MEDICINE CHART No. 4 - LOGARITHMIC SCALE. Figure 127.—Type of logarithmic chart. 458 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 4. By their means it is possible at times to make a person untrained in the statistical method perceive certain facts and appreciate their significance when by other means he could not be made to understand. 5. The relation or the possible relation of one set of facts to another set of facts, and still other facts may be recorded pictorially on a single chart or map. 6. In conjunction with the records for previous corresponding periods of time, graphic records show the trend of current events and sometimes enable one to look into the future for a short distance. NON-EFFECTIVE RATIO PER 1,000 BY OCCUPATIONAL GROUPS, U.S.NAVY, 19 57. NAVY OFFICERS MARINE MIDSH IP POEM ELECTRICIANS engine ROOM ARTIFICERS FIRE ROOM) ALL OTHERS CLERICAL COLINARY MISCELLANEOUS FORCE HOSPITAL MARINES MARINE MUSICIAN NAVY MUSICIAN PgISONEQS NURSES AVIATION APPRENTICES SEAMAN bRANCH ORDMAMCE ALL OTHERS Figuee 128.—Type of bar chart. In administrative work the routine use of graphic records insures that important information which otherwise might be buried in the files and for- gotten will be kept in view. Frequently such records can be used to advan- tage in attempting to convince other persons of the necessity for certain pre- ventive measures. Subject matter of the vital statistics of the Navy. In the Navy vital statistics are limited almost exclusively to morbidity sta- tistics and mortality statistics. In a few instances—Guam and Samoa—birth and marriage statistics are collected for the civilian population. The subject matter of vital statistics of the Navy is composed of— 1. Basic data.— (a) Individual morbidity reports, i. e., the Form F Card, which shows the diagnosis and certain attending circumstances for each admis- sion to the sick list; (b) Individual mortality reports, i. e., the Death Cer- tificate, Form N. 2. Summarized written or telegraphic reports of new eases and deaths. 3. Compilations, i. e., tables or tabulations showing cases, deaths, or rates. 4. Graphic charts, spot maps, or charts posted by means of colored spot pins. Correct vital statistics depend upon the accuracy and completeness of the basic data. Morbidity returns are incomplete when mild cases of a disease are not reported, and incorrect when erroneous diagnoses are recorded. A HYGIENE AND SANITATION 459 morbidity report is incomplete when any of the data required on the form are omitted. Mortality reports are incomplete when any of the required data are omitted, and incorrect when sufficient collateral evidence to insure correct classification of the death with regard to cause is missing. The death cer- tificate also must contain the necessary information to permit charging the death to the station or ship where the disease or injury resulting in death was acquired, and not to the place where death occurred—in a naval hospital perhaps. Purpose of vital statistics. The immediate and most important purpose, from the standpoint of preven- tive medicine, is to furnish information as to when, where, and under what circumstances, loss of manpower is occurring. It follows, therefore, that mor- bidity and mortality reports invariably should be made as promptly as possible. Reports should be forwarded promptly as a matter of routine even when, from the local viewpoint, no apparent reason for haste exists. The historical value of vital statistics is also very great. Complete statis- tics must be prepared for each calendar year. Use of vital statistics. Alone, vital statistics do not necessarily prove anything. The facts thus presented in arithmetical form may or may not comprise all the facts pertain- ing to the question under consideration—almost invariably they do not. All epidemiological factors which possibly may have a bearing on the question must be taken into consideration. It is because of positive but unwarranted assertions based on statistics, by persons who fail to observe proper limitations, owing to lack of thorough training in the statistical method, that uninformed or misinformed persons not infrequently question the value of the statistical method in general, and of any statistics in particular that may be invoked in perfectly logical sup- port of a given contention. The answer to the old saying, “There are two kinds of lies, ordinary lies and statistics,” is, “Figures do not lie, but unfortunately liars do make use of figures.” The idea of comparison always is involved in statistics. The user may not be conscious of this, but everything in the universe is relative to some- thing else, and if any given statistical statement appears to be absolute it is merely because it unconsciously is interpreted and weighed in association with similar information previously acquired. More frequently in practice the at- tempt frankly is made to compare the statistical information under considera- tion with other statistical data, and often with information of a different character as well. Standards of comparison. In order that any fact or set of statistical facts may be compared honestly with other facts in the realm of vital statistics they all must be expressed in the same ratio to population or group in the population. The ratio itself does not matter; that is, the rate may be per 100, per 1,000, per 100,000, or per 1,000,000 of population as best suits the purpose. To change a rate per 100 to the equivalent rate per 1,000 is a simple matter of moving the decimal point over one place to the right. Rates per 1,000 are used for most purposes by the Bureau of Medicine and Surgery. To make satisfactory comparisons it is necessary to have available standard rates, “norms,” so called. The rate for a whole previous year, or preferably 154294°—39 30 460 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the mean rate for a series of previous years, is used for this purpose. Ordinarily figures should not be used for more than the five-year period immediately preceding. Conditions tend to change, and circumstances may not permit true comparison with figures relating to a more remote period. There are certain exceptions to this rule. For example, it may be desired to show a death rate, by years, for a long period of time. In studying the rate from a given condition for a season of the year, a cer- tain month for instance, the similar rates for the corresponding month of previous years should be available, although very likely it will be compared also with the average whole-year rate. As a rule, morbidity and mortality rates are computed for current study by weeks, by months, and by years; occasionally by 5-year or 10-year periods. Exceptionally, as for an epidemic of influenza, morbidity and mortality rates are computed by days in order that a more complete statistical analysis of the outbreak may be made. Rates for weeks or for months or other short periods of time fluctuate widely. The weekly rate is almost sure to vary a great deal from week to week. Because of this the fairest available whole-year rate always should be borne in mind. Naturally it follows that the rate for the week or other short-time period must be expressed in terms of an annual rate in order to facilitate comparison. This is done as follows: The number of cases (or deaths) for the week is multiplied by 52 and the rate then computed. This rate is called the annual rate for the week and one merely assumes that if conditions were exactly the same for the other 51 weeks the whole-year rate would be that figure. It is the practice to express all rates as annual rates, whether for a week, month, whole year, or longer period. In this way any rate may be compared directly with standard rates or with rates for any period of time, shorter or longer, corresponding or different. Population statistics. It is evident that there must be accurate or nearly accurate population (or strength) figures in order to compute approximately correct rates. In civil practice the estimated mid-year population as of July 1 is taken. In the Navy the daily average strength for the period under considera- tion is used. This is determined by taking the total number of daily rations issued and commuted during the period (the figures being obtained from the Supply Department) dividing this figure by the number of days in the period and then adding the number of officers and others not entitled to rations. The larger the average strength the smaller the error caused in a rate by incorrect figures. In any event the omission or addition of one case (or death) will have more effect on the rate than a considerable variation in the strength. Annual rates. The rate for an .entire year is computed by multiplying the number of cases (or deaths) which have occurred during the year by 1,000 and dividing the result by the average strength for the year. An annual rate per thousand for any definite period of time—a week, month, or quarter—may be obtained by multiplying the number of deaths or admis- sions for that period by 365 and dividing the result by the number of days in the period; the figure obtained by division then is multiplied by 1,000 and the result divided by the average strength for the period. If desired, the number of cases (or deaths) for a week may be multiplied by 52 instead of by 365. HYGIENE AND SANITATION 461 Provisional rates and final rates. Morbidity and mortality rates computed from week to week or from month to month must, of necessity, be provisional rates based upon reports for the period in question as received. Final rates ordinarily are not prepared until after the end of the year when final returns have been received. Then the figures may be reviewed and corrections made in weekly or monthly rates by excluding cases (or deaths) which actually did not occur in a given period, and by charging them to the week or month in which they did occur. (In civil practice, in revising death rates, corrections sometimes are made for deaths occurring in the community but chargeable elsewhere.) Current morbidity and mortality rates are prepared as a matter of routine in order that the incidence, distribution, and severity of disease may be determined for comparison with similar figures for past periods and other communities. It must be borne in mind that rates for short periods of time—weekly and monthly rates—fluctuate widely because of epidemic conditions, seasonal and other periodic or cyclic influences, and fortuitous circumstances. Such rates always should be compared with similar rates for corresponding periods of past years, although rates for past whole years furnish a guide as to what may be regarded as a normal average, seasonal and other influences, of course, being taken into consideration. Comparison between one naval station and another, or between ships, and especially between ships and stations, should not be made without taking into consideration a number of conditions which may vary widely—number of per- sonnel, density of population, overcrowding, housing conditions, permanency and character of the personnel, nature of activities carried on, environment, geographical location, climate, and season. Rates other than those expressed in terms of annual rates. Epidemic rate.—Epidemic morbidity and epidemic mortality rates are com- puted simply as the rate per thousand of strength attacked or died as a re- sult of the epidemic, regardless of its length. Attack rate.—Sometimes used to indicate the incidence of a disease among those presumed or known to have been exposed. Generally expressed as the percentage of cases occurring among contacts. With regard to influenza, it is permissible to conclude that practically everybody in the community has been exposed if the disease is epidemic. Case fatality rate.—Percentage of fatal cases among persons attacked by a given disease. Computed by multiplying the number of deaths by 100 and divid- ing by the total number of cases, fatal cases included. To express this,, other terms, such as “mortality,” “mortality rate,” or “death rate,” are frequently used. The objection to use of the expression “mortality” is that it is not always clear that the case-fatality rate is meant. The other terms have an entirely different meaning, viz., the ratio of deaths to the popula- tion or some group in the population. Noneffective ratio.—This indicates the loss of time due to sickness. Along with deaths and invalidings from the service, the noneffective ratio is the final expression of the effect of sickness in terms of loss of manpower. It is the average number of noneffectives per given number of persons during the year, or other period of study. The noneffective ratio per 1,000 average strength would represent the average number out of each 1,000 constantly on the sick list during the period, or the number of sick days per 1,000 man days. 462 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY It is obtained as follows: Number of sick days during period • X i Number of man days during period For a period of a year this would be: Number of sick days per year *—-—————————————1 jtX/U Average strengthX365 (or 366) For per cent of noneffectives multiply by 100 instead of 1,000; for noneffective ratio per 100,000 multiply by 100,000, etc. Minimum rate.—The lowest rate in a series of rates. Maximum rate.—The highest rate in a series of rates. Median rate.—The rate which stands in a series halfway between the minimum and maximum rates. The mode (modal rate).—The rate which occurs in the series with the greatest frequency. In some series the mode is not apparent. The items of a series arranged in order from the minimum to the maximum figure are said to have been placed in array. Mean rate.—The average rate independently computed from the combined basic data included in the series—not the average of the rates. Example: Communicable diseases, Class VIII, at the Naval Training Station, Norfolk, Va., first quarter of 1937; Month Average strength Cases Annual rate per 1,000 3,089 2,899 3,122 412 1, 570. 40 February - 234 1,052. 21 467.64 120 The mean annual rate for the quarter is 1,022.90 (obtained as follows; 766 cases multiplied by 365 and divided by 90; this figure then is multiplied by 1,000 and divided by the average strength for the quarter, 3,037). Average of the rates.—In the example given the average of the rates is 1,030.08 and the discrepancy between this figure and 1,022.90 is obvious. In rough calculations it is often sufficient to take the average of a series of rates, but the figure thus obtained must not be regarded as the mean rate. (See Weighted and unweighted averages.) Combined rate.—The average rate for two or more communities combined— not the average of the rates. Example: Death rate from disease, entire Navy, April 1937: Navy Marine Corps Entire Navy Average strength . ... 114, 489 16 18,366 3 132, 855 19 Deaths from disease- _ - - - Annual death rate per 1,000 . _ ___ 1.70 1.99 1.74 The combined rate is, therefore 1.74. Clearly, it would not be proper to take the average of the rates, 1.84, as the death rate of the entire Navy. If that were done, undue weight would be given to the comparatively small strength of the Marine Corps and not enough to the relatively large strength of the rest of the Navy. If the strengths were equal the combined rate and the average of the rates would agree. This also would hold for a series embracing more than two items if the strengths were all equal. HYGIENE AND SANITATION 463 Other terms used in statistical work. Series of data.—The items of a series may be either rates or basic statistical data (cases or deaths). Geographical series.—The items in the series represent ships, stations, or other places. Historical series.—The items in the series refer to time periods, each series representing a single place. Weighted and unweighted averages.—If the arithmetical averages of two or more series are added together and divided by the number of series the average thus obtained is an unweighted average. It is an average of averages and does not give due weight to differences in strength; an average of the rates instead of a properly computed mean or combined rate as described in the preceding example. Likewise, in dealing with cases or deaths directly, care must be exercised not to take an average of averages or the result will not be a properly weighted average; especially should comparison be avoided between unweighted aver- ages for a series of places, or time periods, and a weighted average for another series. Moving average.—This is calculated as a series of averages moving along, so to speak, through a series of rates. The moving average is most useful where the rates are to be plotted as a curve representing a great many time periods in unbroken sequence, especially when there is reason to believe that the fluctuations observed in the individual rates are largely due to periodic or cyclic influences. Suppose the death rate by years for a given place is plotted on a chart as a curve extending over a long period. There will be fluctuations from year to year, of course. If a curve for successive 5-year averages instead of by single years is plotted, the fluctuations will be smoothed out to a considerable extent, but the effect of unusually high or low rates will be merged in each separate 5-year average and the tendency will be to conceal any periodic effect on the rate that is due to cyclic phenomena which periodi- cally recur, such as epidemics of influenza, measles, unusually bad winters, etc. A curve can be plotted from moving averages that will smooth out fluctuating rates and yet preserve in the comparatively smooth curve the influence of regu- larly recurring fluctuations. This is best explained by an example. Suppose the following series of rates; 3.5, 4.2, 4.0, 6.1, 5.2, 4.2, 4.0, 3.2, 4.6, 4.2, and per- haps a longer series, be taken. To plot a moving average curve on a 3-year pivot (3-year moving average) proceed as follows: The average for the first three rates, 3.5, 4.2, 4.0, is taken and plotted under the 4.0 rate as the first moving average plot point. The next moving average point is obtained from the rates, 4.2, 4.0, 6.1; the next from 4.0, 6.1, 5.2, and so on, dropping a rate and taking up the next in the series for each new moving average point. The following diagram illustrates this, the figures in parentheses referring to the position on the chart of the first, second, third moving average plot point, etc.: 464 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The moving average period may be taken as 5 year, 7 year, 10 year, or other pivot number. The closer the period chosen approximates the periodicity of recurring phenomena the better their influence will be brought out. It some- times is desirable to try two or three moving average periods to see which works out best. The question sometimes arises as to whether the first moving average plot point should be set back. For instance, in a long series of monthly rates the moving average is to be calculated on moving average periods of 12 months; strictly speaking, the first moving average plot point falls on the date of the twelfth month, but it is usually permissible to antedate it to the sixth month, in which case half of the data from which it is calculated lies before and half behind it. Progressive average.—This is a simple matter of plotting under each new rate in the series the average of all preceding rates from the beginning of the series. Suppose the death rate of the Navy by weeks from the first of the year is to be charted. The rates fluctuate from week to week. The progressive average curve shows, each week, the average annual rate from the first of the year to date. Inasmuch as all rates are expressed as annual rates, the progressive average for the last week of the year actually is the annual rate for the year, subject of course to revision upon receipt of final returns. Of course, the correct procedure is to compute the mean rate for each new progressive average point, but for ordinary purposes the average of the pre- ceding rates is sufficiently accurate to show the trend of the curve, which is frequently so obscured by fluctuations that it cannot be perceived without a progressive average curve, plotted along with the fluctuating curve. The follow- ing diagram shows the scheme, the figures in parentheses indicating the posi- tions on the chart of the progressive average plot points. Compilation of statistical data. On board ship, or at a naval station, compilation is ordinarily a simple matter of counting up the total number of admissions to the sick list, or the number of admissions on account of certain diseases, deaths, and number of sick days. The daily average strength must be determined in order that rates may be computed. Where thousands of reports must be handled, as in the bureau, card-punching machines, sorting machines, adding machines, and machines for calculating rates are used. Where a great many reports must be handled without machines, recourse to hand tally sheets must be had. The cross 5 method usually is employed; HYGIENE AND SANITATION 465 Sheets of paper are ruled in accordance with the different combinations of data to be tallied from individual reports. From the figures thus obtained rates may be computed, and these may be presented for study on graphic charts in the form of curves plotted to scale, or as bars plotted or drawn to scale. Before statistical data can be compiled they must be definitely classified, both with regard to the average strength and the type of disease or injury. Average strength is classified in accordance with the established ranks and ratings of the Navy, and composite groups such as recruits, fireroom force, deck force, officers, enlisted men, age groups, force ashore, force afloat, etc. To make accurate classification of diseases possible, medical officers are re- quired strictly to follow the Diagnostic Nomenclature for the Medical Depart- ment of the United States Navy which has been compiled to meet the Navy’s needs. The diagnostic titles in it are acceptable names of: (a) Diseases and conditions grouped in various anatomical, epidemiological, and miscel- laneous classes; (ft) Injuries; and (c) Poisonings. The epidemiological clas- sification of the important communicable diseases is based upon the modes of their transmission which has a more or less direct bearing on measures for their prevention and control. Therefore when a medical officer is in doubt as to which diagnostic titles he should use reference should be made to the classification table in order that the title selected will place the case in its proper class. Care must be used to select the title which actually fits the case. For example, the title, “cerebrospinal fever, meningococcic” is to be used when, in the judgment of the medical officer, the disease is probably meningococcic meningitis, even though meningococci have not been recovered by lumbar puncture or by nasopharyngeal swab. The title “meningitis cere- brospinal” means some other form of acute cerebrospinal meningitis, as pneu- mococcic, streptococcic, etc., other than tuberculous meningitis or cerebrospinal syphilis. Deaths are classified in the bureau in accordance with the International List of Causes of Death, as prepared by the International Commission of 1929 in Paris, France. In order that the health of the Navy may be properly studied data con- cerning disabilities and deaths are compiled in the bureau to show the statistics of: 1. General morbidity and mortality. 2. Each of the more important communicable diseases separately: Cere- brospinal fever, meningococcic; chicken pox; diphtheria; encephalitis, lethar- gic ; influenza ; malaria ; measles ; German measles; mumps; pneumonia, lobar; pneumonia, primary broncho-; poliomyelitis, acute anterior; scarlet fever; tuberculosis (all forms) ; typhoid fever. 3. Communicable diseases exclusive of common infections of the respiratory tract and the venereal diseases. 4. Venereal diseases as a class and separately. 5. Diseases by anatomical systems. 6. Injuries and poisonings: Accidental; homicides and homicidal 'injuries; suicides and attempted suicides; war casualties; food poisonings; and drown- ing, all causes. 7. Diseases only. 8. Injuries only. 9. Poisonings only. 10. Primary disabilities, complications, and squelsea. 466 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 11. Occupational distribution of diseases, injuries, poisonings, deaths, suicides, homicides, and invalidings from the service. 12. Deaths, all causes. 13. Invalidings from the service, all causes. 14. Causative agents of accidental injuries and poisonings. 15. Character of accidental injuries and poisonings. It must be remembered in statistical work that two series of data which vary closely with a third may not' hear a causal relation, or, indeed, any relation whatever to each other. Example involving secondary correlation.—In an epidemic of cerebrospinal fever, meningococcic, the epidemiological factors to be considered are: Number, frequency, and distribution of the cases. Number and distribution of carriers. Length of service of those attacked. Housing conditions. Month of the year and weather conditions. Personal hygiene of those attacked. Fatigue, worry, and exposure to other predisposing influences. Prevalence of other diseases. It is only by establishing direct and indirect correlation between the inci- dence of the disease and these factors (and any other factors which seem to have a bearing) that the whole truth about the outbreak can be determined. Experience during the World War showed that there was low correlation between cases and carriers but that a high degree of correlation existed between the incidence of the disease and certain combinations of the other factors which in turn were closely correlated with each other. Methods of demonstrating correlation are: (a) By graphic charts, comparison of curves or bars and (6) by mathematical formulae involving the use of co- efficients. Demonstration of cause or causal relationship.—1. The synthetic method of proof, by which known particular facts are pieced together in order to reach a more general conclusion. This is the inductive method of reasoning. There must be agreement between the facts which are to be accumulated. It is, therefore, sometimes called the method of agreement. The following rules are applicable to the synthetic method of proof: (a) Rule of agreement: If certain instances of the phenomenon in question have only one circumstance in common, that circumstance is the cause of the phenomenon (or the effect, depending upon the proposition). (h) Rule of difference: When the phenomenon in question occurs in one instance and is absent in another, and one circumstance only is missing in the latter instance, all other circumstances being in agreement, then that one cir- cumstance is the cause or an inseparable part of the cause of the phenomenon (or effect, depending upon the nature of the proposition). (c) Rule of combined agreement and difference: When the phenomenon in question occurs in two or more instances and is absent in other instances, if there is one circumstance common to all instances in which the phenomenon does occur, and all instances in which the phenomenon is absent have nothing in common but the absence of that circumstance, then that circumstance is the cause or an inseparable part of the cause of the phenomenon (or effect, de- pending upon the nature of the proposition). In the synthetic method a few instances are not sufficient to establish proof. The larger the series the stronger the proof. 2. The analytic method of proof.—Deductive reasoning by which a proposi- tion is asserted to be true after which the proof is sought in correct premises, 467 HYGIENE AND SANITATION and so on from one proposition to another until a known truth is reached and the main proposition proved. In other words, the mind looks ahead to the conclusion and then seeks to justify that conclusion by establishing correct premises for its logical proof. This method must be resorted to when it is not clear how to start the ordinary inductive method. The figures for any special grouping of diseases can be obtained quickly in the bureau by means of sorting machines. The groups mentioned are used as a matter of routine, and rates also are computed for each of the 27 classes of the Navy nomenclature classification. Following is a summary of rates used in presenting morbidity and mortality statistics: Morbidity rates: General morbidity rates (rates expressed in terms of the average strength without regard to sex, age,< race, or occupational group). For all causes. For a given disease. For a class of diseases. Specific morbidity rates (rates for specified groups i or classes in the average strength, as by ageJ group, race, or occupational group). For all causes. For a given disease. For a class of diseases. Mortality rates: General death rates (rates expressed in terms of the average strength without regard to sex, age, racej or occupational group). For all causes (this is the crude death rate). For a given disease. For a class of diseases. Specific death rates (rates for specified groups or classes in the average strength, as age group, race,< or occupational group). For all causes. For a given disease. For a class of diseases. Interpretation of vital statistics. It is the main purpose of vital statistics to establish relationship between different facts relating to sickness and death. Such relationship is termed correlation. The underlying purpose, of course, is to determine cause and effect. This brings one at once into the domain of logic. Cause of an event.—The circumstances which must have preceded in order that the event should happen (Jevons; Lessons in Logic). An event seldom has a single cause. Statistics do not in themselves establish cause. However, the first step is to prove the existence of correlation, and this may be ac- complished by the statistical method. Correlation may be simple or complex. Primary or simple correlation (direct comparison).—Two series of data only are compared. Example: Death rates from pneumonia set forth by months, to determine correlation between pneumonia mortality and season of the year. From the statistical standpoint epidemiological data are known as variables. In any given problem one of the variables always is used to interpret or measure the other data and is termed the independent variable. In the example given the death rates are measured by months; months, therefore, constitute the independent variable. Almost without exception, when time periods constitute one of the variables, it is the independent variable. The same is true of classifications such as sex, age groups, races, occupational groups, etc. The data to be measured are termed dependent variables. Numbers of cases, deaths, morbidity and mortality rates, percentage of all sorts of things, bacterial counts, gallons, cubic feet of water, and similar data expressed in varying or fluctuating numbers naturally constitute dependent variables. On a chart the horizontal scale always should be used to show the inde- pendent variable and the fluctuating dependent variable should be plotted to the vertical scale (the numerical scale). 468 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY When correlation is established definitely between two series of data a casual relationship is demonstrated thereby provided connection between the vari- ables also can be established. Connection is not shown by statistics alone. Causal relationship does not necessarily mean the only cause. Secondary or indirect correlation.—Three or more series of data are com- pared, as data not obtainable in suitable form for direct comparison. The processes of logic are more complicated in such instances, and the liability to arrive at an erroneous conclusion is greater. 3. The indirect method of proof.—Logical process of reductio ad absurdum. Fallacies and pitfalls.—There is always danger of unfair comparison of mor- bidity and mortality statistics for different places when consideration is not given to— 1. Comparative reliability of the basic data. 2. The accuracy with which the data for each place were compiled and the methods of computing rates. 3. Epidemiological influences—comparative effect of potent factors. 4. The danger of concealed classification. There is always danger that statistical data which purport to convey certain definite information may be concealing classes such as sex, age, race, color, or particular occupation, which, if revealed, might cause a very different inter- pretation to be placed on the figures. For example, if the incidence rates of pulmonary tuberculosis among employees in two different industries are com- pared a conclusion that one may be more conducive to the development of the disease than the other may be fallacious, because the figures may conceal the fact that the majority of employees in one are very young, while in the other they are mostly persons beyond middle age. In the same way nationality or race may be concealed. Negroes in the United States have a high death rate from tuberculosis irrespective of occupation. The following example illustrates the necessity for constant guard against the introduction of concealed facts: A very extensive experiment to determine the possible prophylactic value of pneumococcus vaccine was conducted in a series of large institutions, by vaccinating every other newcomer, leaving each alternate one as a control. Now, some of these upon arrival were in good physical condition; others not. In cases of choice it practically worked out that an undue proportion of those who were not well to start with fell into the group of controls. For the first few months the death rate from pneumonia was much lower among those vaccinated. The figures concealed the fact that a higher proportion of those unvaccinated probably would have contracted and succumbed to pneumonia under any circumstances. Preventive Medicine and Hygiene.-—Rosenau. Public Health and Hygiene.—Park. Military Hygiene.—Harvard. Military Preventive Medicine.—Dunham. Naval Hygiene.—Pryor. Sanitation in War.-—LeLean. The Medical Department of the United States in the World War, Vol. VI, Sanitation— United States War Department. Sedgwick’s Principles of Sanitary Science and Public Health.—Prescott and Horwood. Solving Sewage Problems.—Fuller and McClintock. Practical Bacteriology, Haematology, and Animal Parasitology.—Stitt, Clough, and Clough. Pathogenic Microorganisms.—Park and Williams. Current publications in the particular subjects, especially of the Bureau of Medicine and Surgery, United States Navy, and the United States Public Health Service. Manual of the Medical Department, United States Navy. References ALLERGY 469 Section 2.—ALLERGY In the United States the word allergy is in general medical use as compris- ing all of the human conditions of specific sensitiveness and excluding the phenomena of experimental hypersensitiveness in the lower animal known as anaphylaxis. An individual may be said to be hypersensitive when he reacts specifically, with characteristic symptoms, to a substance which in the normal individual of the same species produces little or no reaction. For convenience the term anaphylaxis is commonly used in describing certain reactions occurring in the human, but, while it is not possible to assert that anaphylaxis does not occur in man, it is a fact that the existence of the condi- tion of anaphylaxis in human individuals has not been demonstrated and use of this term is now restricted to conditions of sensitization in laboratory animals. Experimental anaphylaxis may be produced in the guinea pig by injecting subcutaneously or intravenously minute amounts of horse serum or egg white and after an interval of at least 10 days the injection of the same quantity intravenously will produce symptoms of shock known as anaphylactic shock, and in some instances death may occur. The term allergy, or hypersensitiveness in the human, includes the conditions known as allergic diseases and for convenience will be considered in the following categories: 1. Atopy or the Inherited Group. A. Hay fever. B. Asthma. C. Food allergies or idiosyncrasies. (а) Gastro-intestinal allergy. (б) Urticaria. (c) Angio-neurotic oedema. (d) Eczema. (e) Migraine. 2. Contact dermatitis. 3. Serum allergy. 4. Drug allergy. 5. Bacterial allergy or hypersensitiveness of infection. 6. Allergy due to parasites. 7. Physical allergy. ATOPY The clinical forms of human hypersensitiveness that are classified under the heading of atopy are so grouped because of their hereditary tendency. This tendency has long been known to play a part in the cause of pollen allergy, some families suffering more than others. Of 500 cases of hay fever, asthma, and food idiosyncrasies, investigators have been able to demonstrate conclu- sively the hereditary transmission of the tendency to become hypersensitive to various proteins. Research investigators have concluded that, when both parents are affected, 75 per cent of the offspring should be affected and that, when only one parent is affected, 50 per cent of the offspring should be affected. The influence of heredity on the age of onset of symptoms of hay fever was shown in the fact that, in those cases in which there was a bilateral inheritance, 36 per cent showed symptoms before the fifth year and in cases where only one parent had a history 14 per cent developed symptoms before the fifth year and where no history could be elicited from either parent the incidence was only 5 per cent. These figures are maintained until the tenth year of life. 470 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The conclusion must be drawn then that “inheritance” does exert a distinct effect upon the age of onset of hypersensitiveness, the more complete the inheritance the earlier the symptoms are manifested. Hay fever. Hay fever is a relatively common condition in the United States and the term originated among the laity from the belief that the symptoms were caused by something given off by hay. It is known under various names as June cold, summer cold, summer catarrh, pollen catarrh, rose fever, ragweed fever, pollinosis and several others. The term hay fever is used to designate those nasal, pharyngeal, and eye symptoms which are the result in the greatest number of cases of specific hypersensitiveness to plant pollen and occur only in the human and bear a hereditary influence. It must be borne in mind that pollens not only produce mild or severe nasal, pharyngeal, ophthalmic and bronchial symptoms, but according to Rowe (1), may produce gastrointestinal symptoms, toxaemia, and migraine as well. Air-borne pollens belonging to the class of inhalants are the important causative factors of hay fever. The pollen from ragweed is the greatest single cause of hay fever in the United States. Certain air-borne mold spores have been recently added to the inhalants causing hay fever and asthma among which the genus Alternaria is the most important. It is estimated that between 1 and 2 per cent of the total population suffers from hay fever. Predisposing causes.—Among the predisposing causes of this disease heredity plays an important role. Coca (2) and Cooke (3) considered the hereditary feature in hay fever or asthma of sufficient importance to designate this type of hypersensitiveness by the word atopy, a word derived from the Greek, meaning “a strange disease.” Age— Hay fever before the third year of age is rare, although symptoms may occur as early as the first year of life. It has been estimated that 25 per cent of all cases occur in the first decade of life, 85 per cent in the second, 25 per cent in the third and 10 per cent thereafter. Race.—It is more prevalent in the white race, occurring less frequently in the black and yellow races. Climate.—Any climate that favors pollination, such as the temperate climates, increases the prevalence of this disease. It has been stated that the air-borne pollens are the important causative factors although almost any pollen may be a cause when in sufficient concentration. In most instances the pollens that cause hay fever symptoms emanate from flowers that are inconspicuous as to fragrance and color while those that are conspicuous as to scent and color and whose pollens are heavy and sticky are insect-borne and not easily carried by the wind, are unimportant as a cause of hay fever or asthma. The pollens of golden rod, dandelion, sun flower, daisy, and rose are examples of insect-borne pollens. There is considerable misunderstanding by the public as to the type of plants causing hay fever. Thommen (4) postulated five requirements for a pollen in order that it produce symptoms: 1. The pollen must contain an excitant of hay fever; 2. It must be wind-borne; 3. It mwst be produced in large quantities; 4. It must be sufficiently buoyant to be carried a consider- able distance by the wind; and 5. It must be produced by a plant which is widely and abundantly distributed. Trees, grasses, and weeds pollinate more or less at different seasons. The most prevalent type of hay fever in the United States is that caused by weeds ALLERGY 471 which pollinate in August, September, and October. This is known as the late summer or fall type of hay fever and the greatest offender amongst the weeds are the ragweeds. The grasses rank next to the weeds and they pollinate in May, June, and July, the hay feyer caused by them being known as the summer type. The pollinating season of the grasses is longer in the Southern States than in the northern. Timothy and June grass are the most important members amongst the grasses. Other grasses are red top, orchard grass, Johnson grass, and Bermuda grass. Tree pollens are the least important of the three groups which cause hay fever. The hay fever caused by them is known as the spring type, the pollinating season usually being short, from April to June. Certain trees in the south are exceptional in pollinating during the summer and winter months. The spring type is caused by the pollens of the poplar, oak, ash, walnut, maple, hickory, birch, beech, and cedar. Pollen concentration of the air is influenced by weather conditions. Rain- fall during the night does not inhibit the crop whereas rain during the day hinders it. Sunshine during the early hours of the day causes the pollen to ripen in large amounts and be discharged. Land breezes are usually laden with pollen while sea breezes are usually free. The direction of the wind also plays some part in producing symptoms such as blowing over areas containing large amounts of pollen. Within the past few years it has become apparent that not all patients suffering from seasonal symptoms of hay fever and asthma fall into any one or all of the pollen groups. According to Pratt (J), many persons suf- fering from hay fever from spring until long after frost are worse during the middle of the summer, between the grass and ragweed seasons. He states that many of these patients are sensitive to air-borne mold spores. Molds may behave like bacteria and produce infection of the lungs, body cavities, and the skin. Typical examples of infection of the skin are the epidermophy- toses of the feet commonly known as Dhobie itch. Molds may also be non- infectious and act as sensitizers similar to pollen and other air-borne excitants or allergens. Skin tests with rapids of the infectious variety produce delayed reactions similar to the tuberculin type of reaction, coming on in 24 hours or more. Noninfectious molds causing hay fever and asthma will produce an immediate reaction consisting of a hive and an area of erythema similar to the pollen reaction. The molds that act as excitants in hay fever and asthma are, in order of their importance, the Alternaria, Aspergillus, Hormodendrum, and Penicillium. The symptoms of hay fever start about the same time every year if the environment has not changed and the patient is not under treatment. The onset is gradual and mild, depending on the concentration of the pollen. Usually the early morning hours are the worst, decreasing during the day and increasing again at night. Local symptoms involve the nose, eyes, and pharynx, the nasal and eye symptoms being the most annoying. The nasal symptoms are sneezing, continuing sometimes until the patient is exhausted, and a profuse serous discharge from the nose which follows or accompanies the sneezing. The eye symptoms are itching, burning, lacrimation (flow of tears) and sensitiveness to light. The lids may be swollen and congested. Itching of the pharynx and a troublesome cough may cause considerable annoyance. Fever does not occur in uncomplicated cases of hay fever. The diagnosis of hay fever is made by a positive history of atopy in the patient or members of his family; the seasonal occurrence; the eye and nasal 472 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY symptoms, and specific sensitivity tests with the suspected excitants as described under asthma. All pollen therapy must be individualized. Specific .treatment by means of pollen extract is well established. The results vary, perfect or almost perfect results are obtained in as high as 35 per cent of cases and satisfactory results are claimed in at least 80 per cent of cases. The purpose of specific treat- ment in hay fever or asthma which is due to an inhalant such as pollen or spores from molds is to increase the patient’s tolerance to the excitant by administering it in gradually increasing doses. In all known cases of hay fever the pre-seasonal method of treatment should be begun 4 to 10 weeks in advance of the expected attack or before the hay-fever season begins, the maximum dose being reached, if possible, before the onset of symptoms. Treatment with the maximum dose is then continued at weekly intervals throughout the hay-fever season. The injec- tions of pollen extract usually number about 15, given at intervals from 2 to 7 days. The site of inoculation is usually the arm or the outer side of the thigh. Pre-seasonal or prophylactic treatment.—The selection of the suspected pollen or other excitant is made from the skin test showing the largest reaction. Where sensitivity is marked, a study of local conditions and a knowledge of plant distribution is necessary to enable one to select the offending agent. Desensitization with the most irritating allergen or excitant will probably afford sufficient relief to the patient. Usually it is not necessary to test the patient with every pollen which the patient may be sensitive to. Pollens of the closely related plants may have a common excitant, such as the active principle of timothy being present in red top, June grass, orchard grass and Bermuda grass. The entire family of the oats may be represented by a single oat. This also applies to the weeds. Many pharmaceutical houses throughout the United States manufacturing the diagnostic pollen allergens for skin testing also furnish information as to the geographical distribution of the various plants. It is usually a good plan to use test and treatment sets made by the same manufacturer to obtain best results. Co-seasonal treatment.—When patients apply for treatment during or just before an attack begins the same method of making a diagnosis by skin tests is necessary. The ophthalmic or eye test cannot be used after the attack has begun. Effective relief from hay-fever symptoms may be obtained by giving small, gradually increasing doses of the pollen extract at frequent intervals. The maximum dosage, which it is wise to give, should be reached at approxi- mately the fifth injection and continued at approximately this level throughout the season. Perennial treatment.—A common method now in use that offers the maximum degree and the greatest percentage of relief obtainable in hay fever is the perennial method of treatment. Patients treated by the pre-seasonal or prophylactic method may carry out their treatment until the season is over. Following this the maximum dose may be reduced to % or % and given semi- monthly throughout the year. As the next season approaches the dose is gradually increased again until the maximum dose is reached before the season starts. Precautions for avoiding reactions.—A few persons may be unusually sensi- tive so that in the course of the treatment some doses may produce a severe constitutional reaction. In such cases the patient should receive at the next visit one-half the dose which caused the reaction. ALLERGY 473 Care should be taken so that no solution is injected into a vessel. After inserting the needle into the tissue pull back the piston of the syringe. In case blood enters the barrel the needle should be withdrawn and reinserted. The patient should remain in the doctor’s office for at least one-half hour for observation. In the case of severe symptoms such as sneezing, itching of the eyes or skin, or difficulty in respiration, 0.5 to 1 cc of epinephrine hydro- chloride, 1-1,000, should be given and repeated if necessary. The interval between doses varies according to circumstances. The next dose should not be given until any marked local reaction from the previous dose has practically disappeared. A blood-pressure cuff or tourniquet may be placed above the site of injec- tion in severe cases of reaction to lessen the rate of absorption and epinephrine solution injected into the other arm or above the constricting band. The band may be loosened after the reaction subsides. Local treatment.—For immediate relief a nasal spray of an aqueous or oily solution of epinephrine 1-4,000 or 1-10,000 is helpful. These solutions may be used as eye drops for relief from the eye symptoms if necessary. Medicinal treatment.—Ephedrine sulfate or chloride in doses of % to % grain by mouth may aid in controlling the symptoms. Atropine sulfate in doses of Viso to Y200 grain lessens the discharge but is of little value in relieving the symptoms. Hay fever resorts.—The selection of districts known to be free from the offending agent offers relief for many. An ocean voyage is beneficial to those who are able to avail themselves of the opportunity. Air filters installed in the patient’s bedroom or office afford relief just so long as the patient remains in the environment. Asthma. One of the common forms of allergy affecting the organs of respiration is asthma, commonly known as bronchial asthma, and may be defined as a condi- tion in which the outstanding feature is wheezy breathing with a prolonged expiratory phase. The causes of this condition are numerous. Bearing in mind the hereditary influence previously mentioned, the causes may be classified as extrinsic, those due to causes or conditions outside the body, and intrinsic, those due to causes or conditions inside the body. Under the extrinsic causes may be enumerated foreign substances inhaled or inspired such as pollens from ragweed and the grasses which are also the cause of many cases of hay fever, dander, and emanations from domestic animals or the feathers of birds, vegetable dusts such as flowers and face powders containing orris root, and other dusts such as house-dust or dust occurring in factories, as leather and wool dust, are offending agents. The intrinsic causes are also very numerous. Among some of the important ones are foods. The ingestion of egg white is one of the most important. Cereal proteins, especially those of wheat, cow’s milk, various kinds of fish and meats and a host of others are also offenders. Bacteria may cause asthma and an attack may follow a cold. Other causes under the intrinsic group are reflex from the nose or throat produced by irritation of the nerves, and foci of infection such as the teeth or appendix. Nervousness associated with faulty hygiene or stress and strain may be a factor, the asthma completely disappearing when the source of anxiety is removed. 474 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAYY Climate influences the frequency of the attacks, and to some extent the severity, by its effect upon vegetation such as pollens. Season has some effect upon the nature or quantity of existing agents, such as pollens, diet and clothing varying with seasons. High temperatures and humidity aggravate the disease while high altitudes have a beneficial action. Age.—About one-third of all cases of bronchial asthma show symptoms during the first decade of life and about one-half start during the next three decades. The symptoms of asthma are as follows: The onset is usually sudden but is more often preceded by symptoms of tightness in the chest, sneezing or a cough accompanied by wheezing. Gradually or suddenly the illness may enter the paroxysmal stage. Attacks of dyspnoea or difficult breathing may recur frequently or at great intervals, the patient may be normal or the symptoms may be those that precede the paroxysm. The patient is frequently awakened from his sleep by an attack He assumes the sitting position, the inspirations are short, slow and deliberate, and the expirations long and wheezy and may be loud enough to be heard at a distance. The patient is pale or dusky, has an anxious expression and may perspire profusely, the so-called “cold sweat.” The attack may last from minutes to several days. There may be only a slight cough at first but this later increases in frequency and is productive of a viscid or sticky type of sputum. The pulse is rapid and usually diminished in volume. There is a characteristic position assumed during a severe paroxysm. The patient bends forward and grips objects tightly or he sits down with the elbows on the knees with the head down so that every accessory muscle of respiration can be brought into play. The diagnosis is usually made with little difficulty and is facilitated by certain characteristic features in the patient’s history, and the symptoms. The most common are as follows: A previous history or family history of allergic diseases classified under atopy; early age of onset; frequently recurring paroxysms of dyspnoea or difficult breathing with normal intervals between attacks; the tendency towards night attacks; examination of the sputum for Curschmann’s spirals, Charcot-Leyden crystals and eosinophiles, and skin tests for hypersensitivity to important inhalants and foods. Skin testing reveals positive results in a large number of cases estimated to be approximately one-half to two-thirds of all cases of bronchial asthma. In obscure cases it is advisable to change sleeping quarters or spend a short time in a dust-free room ventilated by filtered air. When positive skin tests are not obtained by food extracts, trial diets or elimination diets may be tried. Tests for hypersensitiveness may be performed in several ways and have proved to be successful in the diagnosis of asthma, hay fever, and other allergic conditions. Cutaneous or skin tests are made as follows: (a) The scratch technique is the one commonly employed. Any surface of the body which is free from hair such as the flexor surface of the forearm or the back may be used. The area is cleansed with alcohol and allowed to dry, or followed with physiological salt solution, prior to making the scratch. A scratch approximately Vs inch in length in the skin is made with a sharp instrument, needle, or scalpel, being cautious not to cause bleeding. If the powdered extract is used a drop of tenth-normal sodium hydroxide is placed over the scratch and a small amount of powder is nxbbed into it. If pastes instead of powder are used no alkali is necessary, the paste being rubbed into the scratch similar to the powder. A sterile tooth pick serves as an excellent ALLERGY 475 spatula for rubbing the extract into the scratch. After 20 to 30 minutes the solution or paste is wiped off and the reactions are read by comparing them with a control test made "with the sodium hydroxide solution or a paste containing no extract. A large number of tests may be done at one time by this method (fig. 129). (6) The intracutaneous method is also known as the intradermal method and consists of the injection of a very small amount of the sterile extract into the superficial layers of the skin. Amounts Figure 129.—Skin reactions to various extracts; scratch method. (Courtesy Dr. Albert H. Rowe.) not to exceed 0.01 cc are injected using a small gauge needle, care being taken not to inject too many tests at one sitting. Absorption is more rapid than by scratch method and reactions such as an acute attack may be pre- cipitated. The reactions are read from 15 to 20 minutes later comparing them with a control test made with the extracting fluid containing no extract. In suspected cases of pollen sensitivity the conjunctival test may be used by dropping a small amount of the dry powdered extract in the eye. The lower lid is retracted and the powder dropped into the conjunctival sac. Redness with congestion, itching and lacrimation develops in a few minutes if the in 154294°—39—31 476 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY dividual reacts in a positive manner. The powder may be washed from the eye with a boric acid solution and a few drops of epinephrine solution 1-4,000 instilled if the reaction is severe. In the reading of reactions the results of the tests are recorded as negative, doubtful, slightly positive, moderately positive, and strongly positive. A reac- tion is positive when there is a central wheal or light area of erythema or red- ness. The wheal may be absent or very small in some instances while in others it may reach an inch or more in diameter (fig. 130). As a rule the wheal is irregular in outline and may send out pseudopodia into the erythematous area. A test is said to be positive when it exceeds the control in size, either in the amount of erythema or the size of the wheal or both. Figure 130.—Skin reaction to pollen extracts. Positive reaction easily distinguished by a typical hive, irregular in outline, surrounded by a zone of erythema. Cases have been recorded as showing a delayed reaction, the cause of which is not understood, that may appear at the site several hours or days after the test. The treatment of asthma consists of the prophylaxis or prevention of the disease and the treatment after symptoms have developed. Persons suffering from allergic diseases with an hereditary influence should be careful to select an occupation free from exciting factors such as dust, cereal flours, animal danders, and chemical irritants. Areas known to be free from pollens should be selected if possible, or every case of hay fever should be given specific treat- ment. The early recognition of allergic conditions so that precautionary methods may be instituted is a factor not to be overlooked. Treatment of the paroxysm.—Epinephrine hydrochloride solution 1-1,000 is the drug of choice. It is administered subcutaneously in doses of 0.5 cc to 1 cc and repeated as often as necessary until the paroxysm is under control. It is not effective when given orally. Epinephrine hydrochloride solution 1-100 is administered solely by inhalation and is an effective agent for prophylaxis and relief of allergic asthma. Relief usually occurs more rapidly than with the hypodermic injection. The spray is inhaled through the mouth with the aid of an all-glass atomizer which should deliver an even vapor-like spray, free from droplets. Ten drops of the solution are placed in the atomizer and the patient instructed to place the nozzle of the vaporizer just inside the mouth. Five or six inhalations, by squeezing the bulb once or twice, with 2-minute intervals, are usually sufficient. Ephedrine in % to % grain doses may be given orally and has practically the same action as epinephrine. It is slower in its action and is not so effective as epinephrine for controlling a severe attack. It is particularly beneficial in preventing a mild attack from becoming worse. It produces some unpleasant ALLERGY 477 symptoms in some cases such as headache, tremors, nausea, increased pulse, and insomnia. The symptoms are less noticeable or absent in epinephrine. Morphine and atropine have been used but their use should be discouraged. Iodides in the form of the potassium or sodium salts, acting as expectorants, may be given in doses of 5 to 10 grains several times daily. Specific treatment.—The most simple yet effective method of specific treat- ment is prevention of contact with the exciting agents that cause asthmatic symptoms. When this procedure cannot be carried out satisfactorily then relief must be obtained by the methods given next. Relief, and in many cases complete cessation of symptoms, occurs by raising the patient’s tolerance to the exciting agent by its administration in gradually increasing doses. Food hypersensitiveness can be overcome by avoiding the offending food in the diet. Milk as an exciting agent may be combated by the use of evaporated or powdered milks or by substitutes. Oral desensitization or as termed by some, hyposensitization, to important foods such as eggs, wheat, etc., may be attempted by the daily ingestion of small amounts and gradually increasing the amounts until the point of tolerance is obtained. Inhalant sensitivity may be successfully dealt with by preventing contact with the exciting agents such as pollens and dust. Persons sensitive to dust may change their environment to a dust-free atmosphere. This can be accom- plished by removing everything from the room except a bed which is made from substances harmless to the patient. If the contact cannot be avoided the desensitization method described under hay-fever may be resorted to. This is usually not necessary for exciting agents other than pollens, molds, and house dust. Inhalation of smoke of stramonium leaves, the chief constituent of most commercial asthma powders and of special cigarettes for the relief of asthma, often relieves the symptoms if the attack is not too severe. Non- specific protein therapy such as the injection of peptone, milk, venom protein, and vegetable proteins has been tried. Vaccine prepared from the sputum or nasal secretions of asthmatics is a popular form of nonspecific protein therapy. The injection of one’s own blood or serum, called auto-haemotherapy and auto-serotherapy, has produced some favorable results. Under the physical agents for treatment the Roentgen ray is more successful than diathermy, actinotherapy, or hydrotherapy. The artificial means of induc- ing fever by high-frequency current is one of the more recent methods of treatment. All these methods produce temporary results and are unreliable, being comparable in that respect to nonspecific protein therapy. Surgical procedures for the relief of obstruction to the breathing passages such as removal of nasal polyps, straightening of septa, turbinectomy and tonsillectomy produce little benefit. Endocrine substances such as thyroid, parathyroid, corpus luteum and ovarian extracts have proved effective to some extent. Breathing exercises and change of climate have been resorted to. Patients suffering from chronic bronchitis and sinusitis will find a warm, dry climate beneficial. Food allergy. According to Rowe (6), food is the outstanding cause of ingestant allergy. Most physicians realize its frequency as a cause of mild to severe disturbances in most tissues of the body. Many people at some time in life, and especially in childhood, and as late as 50 or 60 years, may have mild or marked food allergy. 478 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Foods which are eaten continuously in excess or at intervals are especially prone to produce allergy, such as milk, wheat, eggs, and various fruits. The tendency to group reactions in some people to foods that are closely related biologically explains sensitization to all cereals such as wheat, rice, corn, barley, and oats. The same is true for citrus fruits, the cabbage group, or to all fish or shell fish. Gastro-intestinal allergy. Rowe states that gastro-intestinal allergy is probably the most common cause of alimentary symptoms. As with asthma, atopic eczemas, urticaria (hives), angio-neurotic oedema, or migraine, the predisposition to develop gastro-intestinal symptoms often exists as a familial tendency. Coated tongue, canker sores, gastric distress, belching, burning, loss of appetite, pain simulating various diseases, and mucous colitis are some of the conditions due to food disturbances. There may be allergic symptoms referable to the liver, biliary system and appendix, due to food disturbances, as well as oedema and smooth-muscle spasm in the genitourinary tract. The gastric tissues are often the site of food allergy. Allergy to foods affects the cells of the gastric glands and accounts for large amounts of mucous. Congestion of the mucosa and of the glands, with muscle spasm, can explain the stomach unrest and injured digestion which leads to belching, disten- sion, sour stomach, nausea, vomiting, tenderness, and even poisoning. In the small intestine there may he idiopathic haemorrhages or bleeding and an excessive amount of mucous due to allergic origin. Localized allergy in different parts of the large bowel often produces sudden attacks of severe cramping pain or persistent soreness which is difficult to explain. The so- called unstable or irritable bowel is a frequent manifestation of allergy. Pruritis ani or itching near the anal outlet frequently results from a local- ized eczema due to food allergy. Urticaria (Hives, Nettlerash). This condition may be defined as an acute or chronic skin disease char- acterized by the sudden appearance of smooth, slightly elevated patches, whitish, pinkish, or reddish in color known as wheals, and attended by severe itching. The urticarial wheal may he allergic or nonallergic in nature. The nonallergic wheal is due to the direct effect of irritant substances such as the toxins or stings and bites of insects and nettles. The allergic wheal is often due to idiosyncrasy to foods. This condition is frequently associated with angioneurotic oedema and when hereditary influence plays a part it may be transmitted through several generations. Causes.—Certain food stuffs appear to be especially liable to cause hives, such as fish, particularly shell fish, eggs, pork, strawberries, and other fruits. Certain drugs mentioned under drug allergy may cause an acute urticaria. Symptoms.—The lesions in urticaria vary greatly in size and shape, ranging from a pin head to a fingernail or larger. As a rule they appear suddenly, although they may be preceded by gastro-intestinal symptoms if due to ingested material. The individual wheals are whitish or pinkish in color, often with a reddish border, and cause intense stinging, burning, and itching. All parts of the body may be affected but the usual sites are the lower trunk and outer surface of the thighs and buttocks. They may appear suddenly and disappear in a few minutes or last hours and even days, leaving no trace. Diagnosis.—In the acute cases the exciting cause may be determined by a history of ingesting food or drugs. In the allergic type a history of symptoms appearing after the ingestion of food should suggest food allergy. A previous ALLERGY 479 personal or family history of allergy in any form may be helpful in locating the cause and eliminating the exciting factor, bearing in mind that allergic manifestations may develop in patients without previous personal or family histories of hypersensitiveness. A history of anorexia or food disagreement is important. Rowe (7) lists his trial diets next in importance as a diagnostic guide when food allergy is suspected. He states skin testing must take a position subordi- nate to history and trial diets in the diagnosis of food allergy. Routine testing of food allergies by the scratch method is important and positive reactions are helpful; however, it is generally recognized that skin tests are negative to 50 per cent or less of those foods which produce clinical allergies. Treatment.—The treatment for the allergic type of urticaria may be divided into specific and nonspecific measures. The specific treatment Includes the avoidance of offending substances and the use of prophylactic injections to raise the tolerance of the patient to these materials. In the case of food allergy the diet is restricted. {See elimination diets at end of this section). Desensitization to foods is not attempted except perhaps in infants and children when they are sensitive to milk and eggs. In the case of serums and drugs causing acute urticaria, avoidance or substitution, if practicable, may be resorted to. The immediate treatment, if due to something ingested which has not left the stomach, is to induce vomiting. A brisk saline purge is indicated as soon thereafter as possible. In a severe attack 1 cc of 1-1,000 solution of epinephrine hydrochloride, subcutaneously, repeated as often as necessary, may relieve the acute attack. Ephedrine sulfate % grain is also helpful. The local application of calamine lotion containing 1 or 2 per cent phenol or menthol is beneficial to allay itching and a saturated solution of sodium bicarbonate, boric acid, or magnesium sulfate will also give relief. Angioneurotic oedema (Quincke’s disease, giant hives). It has been suggested that urticaria and angioneurotic oedema are dependent on the same mechanism, urticaria involving the superficial layers of the skin and the latter involving the skin or mucous membrane and occasionally the viscera, and characterized by transient, circumscribed swellings. The lesions do not essentially differ from those of urticaria, the variation being in size only. The swellings are usually preceded by itching, prickly or burning sensation, and vary in size from a few millimeters up to large areas, in some instances covering nearly the entire back. The swellings may be tense and elastic and nonpitting or soft and pitting. The skin may not change in color over the area or it may be pink or dusky red. Areas commonly involved are the lips, the loose tissue about the eyes and mouth, the tongue, hands and feet, in fact any surface of the body may be affected. The swellings may persist for several days but usually disappear in 24 to 36 hours. The attacks may occur daily or there may be years between attacks. The diagnosis and treatment of urticaria applies equally to this condition. Eczema (tetter, salt rheum). The frequent association of allergic eczema with a personal or family history of asthma or hay fever points toward an hereditary abnormality of the skin. The transmission of eczema through four generations has been reported and it is considered that heredity can act as an important predisposing factor. The excitants of atopic eczema are protein substances in foods which reach the affected parts through the blood after their ingestion. Eczema as an 480 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY expression of hypersensitivity to foreign proteins is most common in the infant, although persons of all ages may be afflicted. In general however, as life advances, the skin gradually develops an immunity to foods and becomes relatively more sensitive to contact reactions. Where eczema is of food origin, particularly in adults, it is usually accompanied by other manifestations of the allergic state. Symptoms.—The disease is characterized by the presence of numerous types of lesions or manifestations such as erythematous, papular, vesicular, or pustular. Several of these may be combined, the most frequent being the papulo-vesicular. The vesicular variety is probably the most typical form of eruption. The majority of the vesicles rupture as a result of scratching or spontaneously and the patch becomes covered with thin yellowish crusts of dried serum and may ooze profusely, producing the so-called weeping type of eczema. Symptoms referable to the gastro-intestinal tract are similar to those of urticaria, namely, loss of appetite, and in the case of some children, gagging and regurgitation occurs when forced to eat food to which they are allergic. Treatment.—The specific measures covering the allergic type of cutaneous conditions under urticaria may be applied to the allergic type of eczema in contrast to the nonallergic type of dermatitis. In recent years contact eczema from the oils of pollens and leaves has been recognized and its treatment with intramuscular injections of such sterile oils has been of some value. Pro- longed pollen desensitization must be instituted when pollen is the cause of allergic eczema. Food being the most common cause of allergic eczema, procedures similar to those under asthma and urticaria are necessary to eliminate the offending food. Asthma and eczema frequently occur together in the same patient or at different times. The constitutional treatment is similar to that for asthma inasmuch as foods aggravate both conditions. Overeating should be prevented. Rowe’s (8) trial diets contain foods which infrequently produce allergic manifesta- tions and are successful in a high percentage of cases that are hypersensitive to certain foods. The general principle in the foundation of these diets has been to include one or two starches and meats, and two to four vegetables and fruits, together with sugar, oil and salt. A milk diet for several days prior to beginning the trial diets is beneficial provided that the individual is not sensi- tive to milk. Other foods may be added gradually. For the acute conditions requiring additional treatment lotions containing soothing drugs, as well as preparations to allay itching as noted under urti- caria, are beneficial. Migraine. Migraine may be defined as a condition characterized by periodic attacks of headache usually accompanied by nausea and often preceded by disturbances in vision. Cause.—An hereditary influence can be shown to exist in many individuals who suffer from migraine. Certain kinds of food that have been known to cause an attack of migraine may cause asthma. In each the attacks are periodic and nervous influences may precipitate an attack of either. This similarity suggests an allergic state may exist in these individuals. There is increasing evidence that a food allergy is the cause in a high per- centage of cases. Diagnosis.—The diagnosis is made on the personal and family history, skin tests for the offending allergen, and elimination diets. ALLERGY 481 Symptoms.—Preceding the attack eye symptoms may develop, later to be fol- lowed by intense pain across the forehead, between the eyes, in the occipital or temporal region and limited to one side. The pain is usually in the same place in every attack. Dizziness and nausea which may lead to vomiting is frequent. The attack usually lasts from a few hours to several days and recurs at varying intervals. They are rarely accompanied by fever. Treatment.—In the cases that have been proved to be due to hypersensitive- ness in the patient, relief was obtained by allergic treatment where all other forms of treatment failed. Rowe reports many successful cases which received complete or nearly complete relief by elimination diets. Stress and strain must be avoided as well as worry. Regularity of meals and regular sleeping hours are essential. Foci of infection from tonsils, teeth, and sinuses must be removed. Symptomatic treatment for the relief of pain consists of aspirin and similar products. CONTACT DERMATITIS The term contact dermatitis is now applied to a condition of specific sensi- tiveness which is limited to the epidermis and appears after surface contact with the exciting cause. This category of allergic diseases was formerly known only through the skin disease known as dermatitis venenata, an acute inflammation of the skin caused by contact with various substances of a chemical, animal, or vegetable nature, and a term which still serves well as the type of a condition that is now increasing in number and importance. There is hardly an occupation which may not yield a special cause for contact allergy. Some of the most important excitants causing this form of dermatitis are derived from the leaf, stalk, and root of various plants such as poison oak, poison ivy {see p. 560), poison sumac, primrose, daffodil, geranium, lily, satinwood, eucalyptus, and many others; chemicals such as formaldehyde, photogravure ink; trinitrotoluol or T. N. T.; paraphenylendiamine, a hair dye; other materials such as coal tar, furniture polish, soap, copra, oil of citronella, adhesive plaster, feathers and many others. Symptoms.—The eruptions of contact dermatitis caused by plants are as a rule vesicular and accompanied by marked cedema or swelling, although purely erythematous eruptions or discrete blisters are observed. The onset is usually sudden, a few hours or days after exposure with involvement of the face, neck, wrists, hands, or ankles (fig. 132). There is a tendency for the dermatitis to spread by the fingers to other parts, especially the forearms or the genitals. Diagnosis.—The diagnosis is made on the history of the case and by specific cutaneous tests using the patch test. This test may be applied in various ways depending upon the material to be tested. The test can be made with the natural material such as a leaf, powder, or fluid. An undiluted oily substance should be applied to a small area of the unbroken skin and the area covered for protection with a square of waxed paper and then with adhesive plaster. Alcoholic or other solutions may be applied to the skin by moistened blotting paper and covered with waxed paper and adhesive plaster. The patient should be instructed to take off the patch as soon as itching is noticed and to remove the oil with alcohol or ether. A positive reaction ap- pears in from 1 to 5 days as a more or less typical contact dermatitis varying from redness to vesiculation or blistering. 482 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Treatment.—The ideal treatment is avoidance of the excitant; however, in many instances the excitant cannot be avoided without great inconvenience or expense. Contact dermatitis which develops in the home regions requires suspi- cion of cosmetics, soaps, foods, fabrics, furniture polish, waxes, cleaning ma- terials, etc. If the history indicates an occupational source a change in occu- pation is desirable if practicable. Figure 131.—Poison ivy branches showing the leaves, fruit, and aerial rootlets. Contact dermatitis caused from the oils of pollens and leaves is treated by intramuscular injections of a solution of the respective oils. Three or four injections have hee,n beneficial in many cases. If the dermatitis is seasonal begin the injections about 3 weeks previous to the expected symptoms, following directions as recommended by the manu- facturer furnishing the treatment material. Testing material as well as the treatment may be purchased from pharmaceutical houses handling biological supplies. ALLERGY 483 Local treatment.—Upon exposure the poison is on the surface of the skin and may be removed by thorough washing and rinsing, using ordinary laundry soap. In the early stages the disease may be controlled by scrubbing the parts with benzine followed by rinsing with alcohol. After the disease has been present for several days these measures are useless and astringents should be used, i. e., calamine lotion, liquor aluminum acetate 1-20 in water, 5 per cent aqueous Figure 132.—Dermatitis venenata (poison ivy). solution of ferric chloride, 5 per cent solution of potassium permanganate, or fluidextract of grindelia diluted with 5 to 10 parts of water. During the exuda- tive stages ointments or oily preparations should not be used as they tend to dissolve and spread the poison. SERUM ALLERGY (SERUM DISEASE) Serum disease (or serum sickness) is an allergic reaction resulting from the administration either into the soft tissues, the blood stream, or spinal canal of 484 HANDBOOK OF THE HOSPITAL CORPS, II. S. NAVY preparations containing a foreign serum. The reaction may be mild or severe. The frequency with which serum disease or sickness occurs makes it impera- tive, if possible, to ascertain whether there is a previous history of having had asthma, hay fever, or any of the allergic diseases. It is also important to know whether serum has been given at any time during life following an injury or in the process of immunization for the prevention of disease. The well-known antitoxins used in the prevention and treatment of tetanus, diphtheria, scarlet fever, and many others are typical examples of those that are frequently admin- istered and in which serum sickness is often seen. (See p. 375.) Symptoms.—When serum is administered to an individual for the first time there is usually a period of 6 to 12 days before the onset of serum disease. In some cases where large amounts of serum have been administered the disease comes on as early as 3 hours after administration and the severity of the symptoms depends upon the susceptibility of the individual. In rare cases illness does not appear for 2 or 3 weeks. Some individuals may show nothing more than a few hives and some swelling of the superficial glands following the administration of large amounts of serum and lasting for only a few days, while others after receiving a few cubic centimeters will show a large number of hives, fever, oedema, painful joints, and swollen and tender glands for several weeks. The common symptom is fever, occurring in about one-third of the cases, the degree of which is often considerable, reading as high as 106° F., although an elevation of only 1° may occur. Associated with fever in a large number of cases is an eruption. The eruption may be urticarial (hives), macular (spotted), papular (pimple), vesicular (blister), haemorrhagic, or in the form of erythema (redness). The serum eruption may be local, occurring only about the site of injection, or general, involving all parts of the skin. The fever and eruption may occur together although not necessarily so. The highest point of the fever is usually accompanied by the appearance of the rash or on the day previous to it. Relapses occur occasionally after being free from 4 to 14 days. Individuals who have had a previous injection of serum in any form, upon receiving a subsequent injection may develop alarming symptoms or even fatal reactions. Persons susceptible to asthma and certain allergic nasal conditions are particularly susceptible. These reactions are termed serum accidents and usually occur immediately. In some cases almost before the needle is with- drawn local itching and swelling occur. If the attack is severe, sneezing, tickling of the throat, choking sensation, cough, or swelling of the face, hands or the whole body may occur. An acute attack of asthma may develop and may be followed by convulsions and death. Those who suffer from asthma due to coming in contact with horses are highly susceptible to horse-serum proteins. Such patients should not be treated with preparations containing horse serum if it can be avoided. If necessary to do so great care must be used in the administration. Treatment.—It has not been demonstrated that serum disease or serum accidents can be entirely prevented. In ordinary serum sickness, which is the common type and follows the injection of serum for the first time, cold applications to the site of injection for the local swelling, and applications of calamine lotion containing 1 per cent phenol, or sodium bicarbonate baths, may be helpful to control the itching. Hypodermic injections of epinephrine hydrochloride solution 1-1,000 in 0.5 cc to 1 cc doses subcutaneously may give relief from the itching, swelling, and rash. In addition to the above measures free elimination, with sufficient intake of fluids, should be encouraged. ALLERGY 485 To prevent grave symptoms, as in serum accidents, an attempt should be made to elicit a history of previous administration of serum or a history of asthma or hay fever. Tests for sensitivity as mentioned later should be carried out and if positive the patient should be considered an unsafe subject for serum treatment by routine methods. Desensitization offers a method of administering serum to many patients who would react violently to serum if given in the usual way. Patients who have asthma which is aggravated by coming in contact with horses may be so sensitive that they cannot be desensitized, but most of those whose hyper- sensitiveness dates back to a previous injection of serum can be treated with the usual amount without danger. Patients who have a history of Figure 133.—Positive reaction to horse serum 10 minutes after intradermal injection of 0.1 cc of 1-10 dilution of horse serum. This reaction would be classed as moderate. asthma or have a strongly positive skin test, should be given the first desensi- tizing dose subcutaneously. Beginning with 0.005 cc to 0.025 cc the dose may be doubled every half hour until a dose of 1.28 cc is given (ninth dose). Then 0.1 cc is injected intravenously and the dose should be doubled every 20 to 30 minutes until the required amount is given. Dilution with physiological salt solution 1-10 is advisable when unrefined serum is used. With patients showing mild skin reactions, which is often the case when persons have had previous serum treatment, desensitization may be shortened by starting with a larger dose and increasing the size of subsequent doses. One should always keep on hand, when administering serum, a syringe con- taining epinephrine hydrochloride solution 1-1,000. The symptoms of serum sickness must be treated promptly should they arise. Administration of serum must be stopped immediately and a tourniquet applied about the site of injection if possible to do so. Epinephrine hydrochlo- 486 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY ride solution 1-1,000 in 0.5 cc to 1 ec amounts should be injected subcutaneously and repeated at short intervals, if necessary, until relief is obtained. Site of injection.—Many physicians prefer the muscular region on the outer area of the thigh for injection of serum because a tourniquet may be easily applied above the site, if necessary, to retard the process of absorption in case serum reactions occur. Serum that is given intramuscularly is less liable to be followed by serum reactions, due to slower absorption and thus serving to desensitize, than when given by the intravenous or intraspinal routes. Sensitivity tests may be either conjunctival or dermal (skin). In the conjunctival test several drops of a 1-10 dilution of normal horse serum are instilled into the conjunctival sac by retracting the lower lid gently and instilling the serum into the outer canthus or angle of the eye. A positive reaction will appear within 20 minutes, manifesting itself by congestion and dilatation of the vessels, increased lacrimation or flowing of tears, and itching. A severe conjunctival reaction may be neutralized by washing out the serum with a solution of boric acid containing a few drops of a 1-4,000 solution of epinephrine hydrochloride. In the skin test a small amount of normal horse serum or the antiserum to be used in the treatment should be diluted 1-10 with physiological saline solution and 0.1 cc. of this dilution injected intradermally in the forearm. The reading should be made in 15 to 20 minutes. In hypersensitive patients there will be a wheal or hive approximately 1 cm. in diameter and a zone of erythema considerably larger (fig. 133). The size of the wheal and erythema depends upon the sensitivity of the patient. A positive reaction indicates that a patient is sensitive and should be desensitized before the administration of serum. Rabbit serum may be substituted for horse serum in certain types of pneu- monia treated by serum in the event hypersensitivity tests with horse serum are positive. Prior to giving rabbit serum the patient should be tested for sensitivity using the same procedure as for horse serum. DRUG ALLERGY Drug allergy may be defined as a condition of hypersensitiveness to certain drugs among which are some of the well-known drugs now in common use, such as arsenic, mercury, bromides, iodides, quinine, morphine, strychnine, antipyrine, aspirin, sandalwood oil, balsam of copaiba, and many others. In most cases the symptoms of drug allergy appear within a few hours after the administration of the drug although the appearance of allergic mani- festations may not appear until after prolonged administration. In some indi- viduals prolonged administration of drugs causes no allergic symptoms but upon resuming treatment at a later date an immediate attack of hypersensitive- ness is brought about. This may persist for some time or disappear completely. One of the most common symptoms of drug allergy is fever, which in some cases is preceded by a chill. Temperatures as high as 104° to 108° F. have been recorded. Various forms of eruptions may occur, the most common are the erythematous or redness, the urticarial or hives, the vesicular or blister, the macular, spotted or blotchy, the papular or pimple, and the hgemorrhagic. Fever may not be present during the eruption nor may the eruption be present during the fever. Other symptoms less frequently noted are oedema, a painless swelling, especially of the face or at the site of injection; swelling of the joints, and in some cases swelling of the lymph glands. The clinical characteristics of drug allergy are readily recognized as the same as those of serum disease. But for the chemical difference between serum ALLERGY 487 and drugs, serum allergy or serum disease and drug allergy would have been identified as the same disease. It is important to remember that sensitivity to drugs may be detected by skin tests. Such tests are carried out by the scratch or patch method using the same technique in preparing the skin as described elsewhere in this section. A small amount of the drug, either in powder or solution, is rubbed into the scratch or applied to the skin, if using the patch test. The reaction to the scratch test may occur at any time from 10 minutes to 24 hours, usually less than 24 hours. The reaction to the patch test occurs somewhat later than the scratch test, usually between 2 and 24 hours. BACTERIAL ALLERGY OR HYPERSENSITIVENESS OF INFECTION A state of allergy may develop in any bacterial infection which ha« become chronic or which, with antigenically identical bacteria, is frequently repeated. The infectious exanthematous rashes such as scarlet fever, the syphilides and tuberculides are examples of allergic reactions. The tuberculides are typical examples of bacterial allergy and are associated with a high grade of resist- ance to the infection. Erythematous reactions of various types are found associated with a number of infections and should be regarded as allergic cutaneous reactions. Erythema nodosum, a skin disease characterized by red, smooth, and shiny nodules on the shins, is found occasionally in tuberculosis, syphilis, acute strep- tococcal tonsillitis and acute rheumatism. Erythema multiforme, another skin disease characterized by a rash of various types is also considered to be an allergic reaction. Obvious foci of infection, especially in the teeth, tonsils, and sinuses, should be eradicated. Urticaria, angioneurotic oedema and asthma have responded to the eradication of foci of infection. Occasionally bacterial allergy compli- cates a case of hay fever or asthma due to other allergens. A group of generalized cutaneous allergic reactions occurs in fungus infec- tions, The prevalent ring-worm infections of the feet and hands, particularly between the toes and fingers, frequently provokes an allergic response in the tissues and they often resist all forms of local treatment applied to the site of the infection. The common fungi responsible for this condition are the trichophyton, epider- mophyton, and monilia. Skin testing with extracts of the various types followed by desensitization with the specific type of fungus has given favorable results in many cases. Tuberculin tests.—Evidence of bacterial allergy is best shown in tuberculosis. Cutaneous tests with tuberculin do not show the immediate wheal seen in pollen allergy but show a delayed reaction, the maximum reaction coming on some hours after the innoculation. The most satisfactory tuberculin test is the intra-cutaneous one known as the Mantoux test. The antigen used in this test may be the purified protein deriva- tive known as Tuberculin P. P. D. or the more familiar Old Tuberculin known as O. T. Purified protein derivative is furnished in tablet form in two strengths. Individuals who do not react to the first strength are reinjected 48 hours later with the second, stronger tablet. The flexor surface of the arm is cleansed in the usual manner and 0.1 cc from the vial labelled first strength is injected just beneath the first layer of skin using a tuberculin syringe and number 26 gauge needle, approximately one-half inch long. The reactions should be read 48 hours after the injection. 488 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The test is read as follows: A negative reaction shows no swelling and little redness or tenderness; a positive reaction (Fig. 134) may be classified according to size, a 1-plus consisting of an area of swelling measuring 5 mm. to 10 mm. in diameter, a 2-plus from 10 to 20 mm., a 3-plus over 20 mm. in diameter, and a 4-plus an area of swelling and necrosis; a doubtful reaction is one character- ized by a trace of swelling measuring 5 mm. or less in diameter. In inter- preting reactions swelling is more important than redness. The first test dose of P. P. D. corresponds to 0.1 cc of a 1-25,000 dilution of Koch’s Old Tuberculin. The latter may be used if desired, but owing to the uniform potency of P. P. D. a large number of extensive reactions previously seen with old tuberculin are eliminated and the purified form is now preferred. Figure 134.—Positive tuberculin test 72 hours after intradermal injection of 0.1 cc of First Test Strength of Tuberculin, P. P. D. (purified protein derivative). Iii Yon Pirquet’s test a drop of Koch’s Old Tuberculin is placed on the forearm and a slight scratch made through the drop. A control consisting of a drop of 50 per cent glycerin is placed several inches from the first drop containing the tuberculin, the skin being scratched in a similar manner. If the test is negative both areas will be the same size. If positive the drop containing the tuberculin will cause redness and swelling while the other will show no such reaction. Moro’s percutaneous test consists of rubbing into the skin over the chest or abdomen an ointment consisting of 50 per cent old tuberculin in lanolin. An area of approximately 4 inches may be used. If positive a reaction is shown by an eruption of papules over the area in 2 to 7 days. A rubber finger cot should be used in applying the ointment. Recently Wolff devised a test similar to the Moro test using a small drop of the ointment and a drop of ointment containing no tuberculin. The drop is not rubbed in but covered, as in the patch test mentioned under contact dermatitis. The test is read in 48 hours producing papules similar to those of the Moro test when positive. Other tests which may lead to unpleasant reactions and have no advantages over the previously described cutaneous tests are the subcutaneous test and Calmette’s conjunctival test. ALLERGY 489 ALLERGY TO PARASITES AND INSECTS Parasites in the intestinal tract or the body tissues may produce various allergic disturbances. Ascarides (round worms), tape worms and ecchinoccocci in particular have been known to cause allergic disturbances. The bitesr of fleas and lice produce manifestations. Inhalants such as the emanations from flies, moths, and butterflies may also produce symptoms referable to the upper respiratory tract. PHYSICAL ALLERGY Duke states that many nasal, bronchial, cutaneous and other allergy-like manifestations may arise from the effects of light, heat, cold, and effort on the body cells. Localized or generalized urticaria is the most common single symptom of physical allergy and is not often lacking. The cause for this condition is not definitely known; however, experiments lend weight to the conception that urticarial wheals and probably some of the other manifestations of physical allergy are but normal responses to the pres- ence of histamine or, as Rowe states, the physical agent may act as a trigger mechanism which releases an underlying potential ingestant, inhalant, or possibly a bacterial sensitization. Elimination Diets (Rowe) Diet 1 Diet 2 Diet 3 Diet 4 Rice. Com. Tapioca. Milk.i Tapioca. Rye. White and sweetpotato. Rice biscuit. Corn pone. Lima bean potato bread. Rice bread. Corn rye muffin. Rye bread. Rye crisp. Soya bean lima bean bread. Lettuce. Tomato. Beets. Spinach. Squash. Carrots. Carrot. Asparagus. Lima beans. Beet. Peas. String beans. Artichoke. String beans. Tomato. Lamb. Chicken. Bacon. Beef. Bacon. Lemon. Pineapple. Lemon. Grapefruit. Peaches. Grapefruit. Pears. Apricots. Prunes. Peaches. Apricots. Cane sugar. Cane sugar. Cane sugar. Wesson oil. Mazola oil. Olive oil. Olive oil. Wesson oil. Wesson oil. Salt. Salt. Gelatin. Gelatin. Karo Corn sirup. Salt. Syrup made of maple sugar or cane sugar flavored with mapeline or maple sugar. Olives. Pear butter. Gelatin. Olives. Maple syrup or syrup made with cane sugar flavored with maple. i Milk should be taken up to 2 or 3 quarts a day. Tapioca cooked with milk and milk sugar also may be taken. Note.—Wesson (Cottonseed) Oil is included in all diets. With allergy to cottonseed as shown bv skin test or history this must be excluded and a cottonseed-oil shortening must not be used. If allergy to cane sugar is suspected, beet sugar or corn glucose may be used. (1) Gastrointestinal Allergy.—Albert H. Rowe, Nov. 22, 1935. (2) (3) A. F. Coca and R. A. Cooke.—Journal of Immunology 8: 136; 1923. (4) Etiology and Hayfever.—A. A. Thommen; New York State Journal of Medicine, 30; 437-442, 1930. (5) Seasonal Aspects of Asthma and Hayfever in New England.—Henry N. Pratt; New England Journal of Medicine, Vol. 219, No. 20, P-782, Nov. 11, 1938. References 490 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY (6) Allergy. Its Recognized Causes.—Albert H. Rowe; North West Medicine, Vol. 34, Nos. 10 and 11, Oct. and Nov. 1935. (7) Elimination Diets for Diagnosis and Treatment of Food Allergy.—Albert H. Rowe; American Journal of Digestive Diseases and Nutrition, L : 387-392, August 1934. (8) Clinical Allergy—Manifestations, Diagnosis and Treatment, 1937.—Albert H. Rowe. Serum Sickness and Serum Accidents.—G. M. MacKenzie, in Textbook of Medicine, Cecil. Hypersensitiveness.—A. F. Coca, in Practice of Medicine, Tice. M. Walzer, in Practice of Medicine, Tice. Diseases of the Skin.—C. G. Andrews. Cutter Laboratories, Berkeley, Calif. Eli Lilly and Co., Indianapolis, Ind. Parke, Davis and Co., Detroit, Mich. Lederle Laboratories, Inc., New York, N. Y. B. R. Squibb and Sons, New York, N. Y. Illustrations (figs. 130 to 134 inch) by Glen Leith, Vallejo, Calif. Section 3.—GENITOURINARY AND VENEREAL DISEASES The male genitourinary system. In the male the genital and urinary systems are so closely associated, both anatomically and functionally, that they are often referred to as one system, the genitourinary. The anatomy of the different structures comprising these systems has been described in the chapter on Anatomy and Physiology. DISEASES, INJURIES, AND ABNORMALITIES OF THE MALE GENITALIA The most common diseases of the penis are chancre, chancroid, gonorrhoea, cancer, tuberculosis, and elephantiasis of the foreskin. Injuries include crush- ing, laceration, fracture, and complete loss by cutting or crushing. A urinary fistula is a false passage from the natural urinary passage in the penis to the external surface and usually follows abscesses of the urethra or injuries. The scrotum has few diseases. The more common are elephantiasis, in the tropics, cancer, and sometimes chancre and chancroid. Injuries of the scrotum are usually lacerations or bruises. The testes ordinarily have the following diseases: Syphilis (gumma), mumps, and tumors. The testes are rarely attacked by the gonococcus and tuberculosis, and are rarely injured except intentionally, in mutilation, which may be self- inflicted. The epididymis is most commonly infected with gonococcus and next with tuberculosis and finally with ordinary pus germs. In some instances it is at- tacked by syphilis. It is rarely injured, excepting in grave injuries which involve the testicle. It may have tumors in rare cases. The vas, the prostate, and the seminal vesicles are most frequently attacked by the gonococcus, tuberculosis, ordinary pus germs, and sometimes by syphilis. The prostate has, in addition, cancer and an enlargement which ob- structs urination in old men is called hypertrophy. Varicocele is an enlargement of the veins of the spermatic cord. Hydrocele is a condition in which the sac surrounding the testicle is filled with a watery, serous fluid. It may reach an enormous size. Hcematocele is the same as hydrocele, except that the fluid is blood. Undescended testicle may mean that the testicle is within the abdomen (it descends normally in the seventh month of foetal life), or it may have stopped in the groin, or it may hang on the corner of the pubis. Epispadias is a malformation of the penis in which the urethra opens on the top. GENITOURINARY AND VENEREAL DISEASES 491 Hypospadias is a malformation in which the urethra opens underneath the penis. Hermaphrodites are unfortunate individuals who have faulty development of the genitalia and partake of the characteristics of each sex, so that in extreme cases it is difficult to determine to which sex they belong. There is doubt if there is ever a true hermaphrodite, as this would depend on careful study and proving the presence of both true ovary and true testicle in the same individual. Pyelonephritis and pyonephrosis are infections which involve the pelvis of the kidney. When the pelvis alone is involved it is termed pyelitis. Ureteritis, cystitis and urethritis are conditions which indicate inflamma- tion of these organs, the result of infection, chemical injury, or traumatic Injury. Stones or calculus formations may be found anywhere in the urinary tract. In general the treatment of the foregoing lies beyond the scope of the hospital corpsman. However, there are a few conditions and treatments of which mention must be made. Phimosis is a deformity of the foreskin which renders its retraction behind the glans, or head of the penis, impossible because of the small opening in the foreskin. The condition often induces an attack of balanitis or balano- posthitis. The remedy is circumcision, but if no medical officer is available for several days it should be cut on top; using injections of 1 per cent pro- caine or novocaine for anaesthesia. The cut can be made with a sturdy, sharp pair of scissors or with a knife on a grooved director which has been passed between the foreskin and the glans, being sure that the director is above the glans and not in the urethra. Care must be exercised to avoid cutting the glans and the cut should be extended far enough back so that the foreskin can be pulled back and everything seen. Bleeding can easily be stopped by tying off the bleeding points with catgut or silk ligatures. Paraphimosis is a condition in which a tight foreskin has been retracted behind the head of the penis and cannot be brought forward readily. The small opening in the foreskin forms a band of constriction on the dorsal surface of the penis, which, interfering with the circulation of the blood, causes more or less deformity of the organ from oedema. The condition causes great discomfort and if neglected may go on even to ulceration and gangrene of the foreskin and head of the penis, with possible loss of the glans. The first requirement of treatment is the immediate reduction of the dis- placed foreskin. This often can he accomplished in the following manner: With the two thumbs pressing on the head of the penis at either side of the meatus, and the index and middle fingers behind the constriction, the blood is pressed out of the head, which being thus reduced in size and softened, is pushed back through the constricting ring and the foreskin drawn forward. Should this procedure fail, owing to the tightness of the constriction, and the head of the penis shows great swelling and purpling, the tight constricting baud must be found and a small longitudinal incision made completely through it on the dorsal surface, under local anaesthesia, so that the foreskin may be brought forward. The wound should be dressed with sterile gauze. In injuries to the penis, scrotum, and testicle, bleeding m$ay be dangerous, and if no medical officer is available an effort must be made to stop it. The first thing is to give morphine by hypodermic, at least one-quarter grain, re- peated in a couple of hours if necessary, to quiet excitement. As a rule 154204°—30——32 492 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY do not put on a tourniquet, but try to find the bleeding points and then clamp and ligate them with catgut. Tourniquets may destroy the only chance of saving the part, because they shut off all the blood supply. In cases where rings, wire, rubber bands, etc., have been placed around the penis, they must be cut or filed off at once; otherwise the swelling may produce gangrene and complete loss of the part. If too strong solutions are introduced into the urethra by accident, give mor- phine, at least one-quarter grain, by hypodermic at once. In general pass no instruments, but inject gently plenty of sterile water. If the solution was lye or other alkali and the condition is seen early, inject vinegar or acetic acid, one-half of 1 per cent. Again, if the solution was nitric or sulfuric or some other acid, inject a solution of sodium bicarbonate, a teaspoonful to a pint. If phenol, inject magnesium sulfate, a tablespoonful to a pint. Bichloride of mercury is neutralized with the white of an egg. Iodine is neutralized with starch water. An ice bag will help keep down swelling. The services of a medical officer should be obtained as soon as possible. THE VENEREAL DISEASES The venereal diseases are those contracted almost always through sexual inter- course and include syphilis, gonorrhea, chancroid, and lymphogranuloma, vene- reum. These diseases are very prevalent in every community and do a great deal of damage not only to the individuals affected but to the community by reason of invalidism and premature death. In a military service the venereal diseases cause much loss of efficiency. In the year 1917 the British Army lost the services of 98,000 men as a result of venereal disease. During the same year the total number of admissions from venereal disease in the United States Army was 71,955, resulting in 875,553 sick days. In the United States Navy during the 9 years 1909 to 1917, inclusive, an average of 158 men out of every 1,000 were admitted to the sick list for venereal disease. It is highly probable that every person who indulges in promiscuous sexual intercourse sooner or later acquires one or several of the venereal diseases. It has been estimated that 60 per cent of the adult male population of the United States have had gonorrhea. Now that routine Wassermann tests are made in many large civil hospitals, it is found that from 20 to 30 per cent of all admissions give a positive reaction indicating syphilis. In 1917, in a large Pacific coast city, 97 per cent of the prostitutes were found to be infected with venereal disease. In a city on the Atlantic coast, 96 per cent of the prostitutes had venereal disease. These statistics may serve as an index of the prevalence of venereal disease among persons who practice promiscuous sexual indulgence. The effects of venereal disease are far-reaching. In the case of syphilis the effects are in the beginning slight and local, but as the organism which causes the disease spreads throughout the body they become grave. One great danger is that early in the progress of the disease the symptoms are often so trivial that no anxiety is aroused in the patient’s mind. The symp- toms may be so slight as not to be observed. The patient may not seek treat- ment and he may succeed in unknowingly infecting other people. When the infection becomes generalized every organ and every system in the body may be attacked. Syphilis is especially liable to attack the walls of the arteries. When this occurs the muscular portion of the artery often is replaced by nonelastic fibrous tissue. The artery becomes thickened and hardened. Hardening of arteries is a natural process which accompanies advancing age, but the hardening process resulting from syphilis is much more rapid and dangerous GENITOURINARY AND VENEREAL DISEASES 493 as far as life is concerned. If the arteries of the brain become thickened and hardened the blood supply is diminished and the portion of the brain supplied with blood by the artery affected ceases to exercise its function. What the symptoms will be depends upon what part of the brain is involved, but the condition may cause mental debility, insanity, loss of speech or memory, or paralysis. Syphilis frequently attacks the aorta, the great artery leading from the heart. A part of the wTall of the aorta becomes thickened and loses its elasticity by the formation of fibrous tissue which is weaker than the muscle in the wall of the vessel. The force of the blood stream causes a bulging of this weakened part and in time the wall becomes thinner and the bulging greater until eventually a distinct pouch is formed. The bulging of an artery in this manner is known as an aneurysm. The thinning of the wall makes the aneurysm very liable to burst. This often happens and the patient dies sud- denly. Syphilis frequently causes disease of the heart or other important Internal organs. Perhaps the most important part of the body attacked by syphilis is the nervous system. Either the brain or the spinal cord, or both, may be affected. Once the organism of syphilis has lodged in the nervous system it is extremely difficult to evict it. A man with syphilis, if he marries, may infect his wife, and a child bom after the infection is apt to show grave manifestations of the disease. Syphilis is a most frequent cause of miscarriage in pregnant women. The local inflammation of the urethra, which is all that most patients see in gonorrhoea, is actually the least of its dangers. Apart from the danger of infection of the eyes and the general infection of the body resulting in heart disease and gonorrhoeal rheumatism, the complications due to direct extension of the disease are different in the two sexes. In man all of the organs con- nected with the genito-urinary tract may become infected. In women grave complications are common. Invasion of the uterus, the Fallopian tubes, and the peritoneum by the organism is frequent. This invasion takes place either shortly after infection or after the birth of the first child. The gonorrhoea may subside and become quiet in the glands of the mucous membrane of the vagina until pregnancy excites a congestion that increases the virulence of the bacteria causing the disease. By these virulent organisms the child’s eyes are endangered at birth; its mother’s uterus and Fallopian tubes immediately thereafter. It is estimated that in 10 per cent of blind children the blindness is due to gonor- rhoeal infection of the eyes during birth. Over 60 per cent of the inmates of asylums for the blind are made blind by gonorrhoea. Gonorrhoea of the uterus and Fallopian tubes usually makes a woman sterile—that is, unable to conceive children. Besides depriving a woman of her children, gonorrhoea may render her a permanent invalid—may even cost her her life. It is a curious fact that gonor- rhoea in women is either much milder or much more severe than the disease in man. Some women while heavily infected have few or no symptoms of the disease and are not inconvenienced by it. Others are overwhelmed hy gonor- rhoeal abscesses in the Fallopian tubes, in the pelvis, or by peritonitis. They must undergo severe surgical operations or die; should they recover they often are invalids the rest of their lives. Syphilis. This is a generalized, chronic, infectious disease that attacks any and every part of the human body. It occurs in two forms, acquired and hereditary. Acquired syphilis is communicated by a syphilitic person to one free from the disease, the point of inoculation always being marked by a sore called the initial lesion or chancre. Hereditary syphilis is transmitted to the unborn child from one or both of its parents; in this form there is no initial lesion, 494 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the onset of the disease being marked by general manifestations which may be noticed at the time or shortly after the syphilitic child is born. The cause of syphilis is the Treponema pallidum, a microorganism belonging to one of the lowest families of the animal kingdom, the Spirochcetacew, or spirochsetes. This organism is shaped like a corkscrew sharpened at both ends, is very active, and is very easily killed by heat, drying, sunlight, and anti- septics ; its transmission is easy by sexual intercourse, and it is not infrequently transferred by the kissing, biting, and scratching of infected persons, or the use of the toilet articles, eating, drinking, or smoking utensils, pencils and pens, etc., of infected persons with open lesions. It may also be transferred through the handling of open lesions. While it is believed that there must be at least a slight break in the skin for its entrance, there is no certainty that such a break is necessary. Acquired syphilis, to which this discussion will be confined, is usually divided into three stages, the primary, the secondary, and the tertiary. The primary stage consists of two periods of incubation, the first of which exists from the time of exposure to the appearance of the initial lesion and, as a rule, lasts from 14 to 21 days but has been noted within as short a time as 3 or 4 days and as late as 4 months. This is followed immediately by the second period of incubation which dates from the formation of the initial lesion to the de- velopment of certain constitutional manifestations and usually occupies from 40 to 45 days but may be prolonged much longer. The initial lesion, primary sore, or; chancre appears on the penis, scrotum, or elsewhere. Usually there is but one sore which is a hard and cupped-out ulcer showing a tendency to heal slowly and giving little if any pain. These sores vary greatly in their character and some are so small and insignificant that they escape the notice even of cleanly persons. The near-by lymph glands are swollen, but not painful ex- tender, and do not tend to form pus. Blood tests in this stage are seldom posi- tive. The secondary stage, or secondaries, is characterized by the appearance of the constitutional manifestations consisting of any or all of the following: Rashes on the skin, superficial lesions on the mucous membranes, general en- largement of the lymph glands, headaches, fever, pain in the bones, muscles, and joints, and falling hair. The duration of this stage is variable, usually be- ing from 1 to 2 years, and in it the blood tests for syphilis are generally posi- tive. Should the result of the first blood test be negative repeat tests should be made at intervals for at least 1 year after the appearance of any suspicious lesion, particularly one located on the genitalia. The tertiary stage usually begins at about the end of the second year but may not appear for years after symptoms of the secondary have disappeared. It is not seen so frequently today as formerly because of modern methods of treat- ment. It manifests itself by tumor-like swellings called gumma, destructive lesions in the nose and other parts of the body, affections of the heart and blood vessels, liver, kidneys, bones, and sometimes of the nervous system, the latter producing paralysis, insanity, etc. Tertiary manifestations may simulate every symptom known to medicine. The treatment of syphilis should be begun just as soon as a positive diagnosis is made, even if the disease is still in the chancre stage. The prognosis is much better if efficient medication is given before the organisms have had an oppor- tunity to produce tissue changes throughout the body. Although the details of treatment cannot be fully gone into here it may be stated that it consists principally of the administration of salvarsan, mapharsen, neosalvarsan, silver-arsphenamine, tryparsamide, and sulfarsphenamine, all be- longing to the arsenical group, the first five being injected into the veins, and GENITOURINARY AND VENEREAL DISEASES 495 the latter being injected deep into the buttocks. Mercury is given by mouth, by inunction,, and by injection deep into the buttocks, bismuth subsaliscylate is injected deep into the buttocks; iodide of either potassium or sodium usually is given by mouth, and the latter sometimes into the veins. The disadvantages and dangers of these substances will be mentioned under a paragraph devoted to that subject. Local treatment amounts to very little, and no antiseptic should be put on a primary sore until the sore is definitely diagnosed. Dress it with warm physio- logical salt solution only and do not even use soap, because this and antiseptics interfere with finding the microorganism. Every case with open sores should strictly adhere to the use of their own clothing, towels, bedding, pipes, toilet articles, etc., and separate toilet seats and separate mess gear should be provided. If possible they should be kept in separate wards and should not be allowed to go on liberty. All dressings should be burned and hospital corpsmen dressing such cases should wear gloves, especially if they have any cuts or scratches on their hands. If gloves are not available, the hands should be washed thoroughly with soap and water immediately after dressing the case. They should not skylark or wrestle with such patients. If a medical officer or hospital corpsman should cut or prick his finger while working with these cases the wound should be cauterized at once which will practically always prevent infection. An entry of such an acci- dent should always be made in the health record of the individual concerned. The diagnosis of syphilis in the primary stage is made by demonstrating the Infecting organism in smears from the chancre by means of dark-field illumination. This method is described in the section on Laboratory Procedures and Technique. The blood tests used in the diagnosis of syphilis are possible because of the characteristic changes in the blood serum as a result of the invasion of the spirochgetes, and are known as serological reactions. In them the serum of an infected person reacts specifically with certain substances from normal tissues. Principal among these tests are the Kalfn flocculation test and the Wassermann complement fixation test, the details of which are too technical to be given here. There are many other tests, such as the Noguchi, Emery, Kline, Hin- ton, etc. Changes may occur in the cerebrospinal fluid of persons infected with syphilis and positive Kahn and Wassermann reactions with it can also be obtained. There are other tests of the cerebrospinal fluid that may be used in the diag- nosis of syphilis. In some instances there may be repeated positive serological reactions with- out history, symptoms, or other signs. In such cases the diagnosis of Syphilis, sero-positive only, should be used in reporting the condition. With treatment the reaction in these tests usually grows weaker and finally becomes negative, but many cases responding well to treatment never become negative. It should be remembered that there are some other diseases that will give positive Kahn and Wassermann reactions, of which one is yaws. Chancroid. This is an ulcerative type of disease whose action is local in character, not generalized like syphilis, being limited to the parts where it occurs and related lymph glands. The word means “like a chancre,” and nearly always occurs in those who are most uncleanly in their habits, being preeminently “a disease of dirt and filth ” 496 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The cause of chancroid is undoubtedly the Haemophilus ducreyii (Bacillus of Ducrey) which is often called the streptobacillus of Ducrey because it occurs in the form of short rods end to end like a chain until ulceration sets in. Its transmission is commonly by sexual intercourse and it may be transferred by inoculation in an abrasion of the skin of another person or of the person already infected, as the secretion of a chancroid is highly infectious. Chan- croid nearly always occurs on the genitals, occasionally in the anus or mouth in cases of perversion, and rarely on the hands, etc., by accidental infection. On the male genitals it is most common in the groove behind the penis, especially in the little pocket on each side of the frsenum, but it may occur on the head of the penis, the inner surface and free border of the foreskin, and the skin covering the penis. Chancroid is characterized by an ulcer that is usually painful, tender, soft, prone to bleed easily, and has a tendency to spread and form secondary ulcers. These ulcers are likely to be phagedenic and destroy tissue, and may finally destroy the whole penis. The first ulcer usually begins as a small pustule surrounded by a highly inflamed area. The pustule soon breaks down and leaves a round or irregular ulcer with sharply defined edges and undermined walls. The floor of the ulcer is rough and generally is bathed by a purulent secretion which is very infectious. There is a varying amount of inflammatory thickening of the tissues around and beneath the sore, which shades off gradu- ally into the surrounding parts, thus differing from the ring-like induration of the syphilitic chancre which is hard and sharply outlined. The chancroid is prone to form buboes which are painful and tender, and usually form pus. The chancroid has no fixed period of incubation, its development is rapid, and it usually appears in 2 to 5 days after infection. In addition to forming bilboes chancroid may be complicated by mixed infec- tion with syphilis and with pyogenic organisms, by destruction of the frsenum. by phimosis, balanoposthitis, etc. The treatment of chancroid should never be started until after the sore has been studied to make sure that it is not a chancre, because it is always possible that any sore on the penis is syphilitic. It should be dressed at first with warm physiological salt solution only, and repeated examinations of the secretions for the presence of Treponema pallidum should be made. When it is decided that the sore is a chancroid local treatment should be immediately started. There are many remedies but probably the best in order, would be copper sulfate, nitric acid, phenol, alum, chlorinated lime water, calomel ointment, etc. On account of pain it is usually necessary to apply a 4 or 5 per cent novocaine or procaine solution to the sore before carrying out the more drastic treatment. Although there may appear to be no syphilitic element present some very bad phagedenic chancroids may be healed by an intravenous dose or two of salvarsan which is probably due to the tonic effects of the arsenic in the salvarsan. Gonorrhoea. Acute anterior urethritis, or clap, as gonorrhoea is commonly called, is a local inflammatory disease usually affecting the raucous membranes of the urethra in the male and the urethra and cervix uteri in the female; by accident or perversion, the mucous membrane of the anus or mouth; and, by accident, the conjunctivse of the eyes. It does not occur in any of the lower animals. The causative organism may extend and infect any part of the genito-urinary tract, and may attack joints, the valves of the heart, and even the meninges by entering and circulating in the blood stream. The word gonorrhea is a mongrel one from the Hebrew and Greek languages meaning “flow of semen,” which is, of course, incorrect. GENITOURINARY AND VENEREAL DISEASES 497 The cause is the Neisseria gonorrhcew (gonococcus) which belongs to the family of bacteria known as the Coccacese, or cocci. When stained and viewed through the microscope they usually are seen in pairs, either within or outside of pus cells, and have the appearance of two coffee beans with their flat sides together. In the earliest stage of the disease, when the discharge is glairy, a considerable number may be seen lying free or adhering to the surface of cells thrown off from the inflamed mucous membrane, but when the discharge becomes purulent the large proportion within pus cells is very striking. The transmission of gonorrhoea of the male urethra may be said to be by sexual intercourse only, through the deposition of the gonococcus on the mucous mem- brane of the urethra during intercourse with a woman having the disease. Its transmission to other parts of the body is by the hands, towels, etc., or by perverted practices. The usual manifestation of gonorrhoea of the urethra is a local inflam- mation of the infected surface which is characterized by redness, swelling, and exudation of pus at the outlet of the urethra as a creamy drop. During intercourse the gonococci enter the anterior part of the urethra and proceed to grow into the delicate lining membrane and set up an inflammation which becomes noticeable usually about the fourth day after exposure but may be as early as 24 hours or as late as 10 days. The first sign is usually a. slight sensation of burning, itching, or pain about the urinary meatus, and some- times a slight desire to urinate frequently. The pain or burning is most marked during urination owing to the irritation caused by the urine passing over the inflamed area. After a day or two a small quantity of glairy mucus can be squeezed out from the meatus, the lips of which now appear slightly reddened and have a tendency to stick together. The mucous stage lasts for about 24 hours after which the discharge becomes decidedly purulent in character, the pain is sharper and during urination there is a marked burning sensation in the urethra. The discharge becomes profuse, yellowish-green in color, creamy in consistence and sometimes tinged with blood, the lips of the meatus and often the entire head of the penis are bright red in color, hot, and swollen. In severe cases the lymphatics on the dorsum of the penis become swollen and painful, and as they communicate with the inguinal glands these latter may become enlarged and tender. The infection spreads and the entire anterior urethra becomes inflamed. Every act of urination is now painful as the urine is forced through the urethra, whose caliber has been greatly lessened by the swelling of its mucous membrane. The pain may be so severe as to inhibit the passage of urine. Painful erections (chordee) occur, especially at night, which rob the patient of his rest, and in this way cause debility, general malaise, and nervousness. The symptoms increase in severity up to about the third week of the dis- ease, and then in favorable cases gradually decline until at the end of about 6 weeks the patient is practically normal. The discharge almost disappears and the only reminder of the disease may be a little moistness at the meatus in the morning. The patient perhaps considers himself cured, but may find that any dietetic indiscretion, such as the drinking of alcoholic beverages or sexual intercourse, causes a reappearance of the symptoms. The foregoing description refers to an uncomplicated and untreated case. Although the patient is free of symptoms, he is not cured. The disease merely has become chronic. The urethra has become tolerant to the gonococci which are still present, as generally can be shown by microscopic examination. Chronic gonorrhoea, or gleet as it is sometimes called, is a serious matter. It is the man with chronic gonorrhoea who mainly is responsible for the spread 498 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of the disease. The patient is quite unaware that he is in an infective state and he may marry without any misgiving. The gonococcus to which his urethra is practically immune is then implanted in the vaginal mucous membrane of his wife, and in this fresh soil takes on renewed activity. It not infrequently happens that such a man after a few weeks of married life finds symptoms of acute gonorrhoea developing in himself. He usually suspects his wife and serious domestic trouble may result. In reality all that has happened is that he has been reinfected by his own organisms which have become rejuvenated by their residence in the genital passages of his wife. The gonorrhoeal process rarely is limited to the anterior urethra. In about 90 per cent of all cases of acute gonorrhoea the infection passes quite quickly up the urethra to and beyond the region of the compressor or cut-off muscle of the urethra. When this locality is passed inflammation is set up in the posterior urethra. This invasion of the deeper parts of the urethra may take place gradually and with such mild symptoms as to escape detection; but in the majority of cases it is indicated by a sudden and very marked decrease in the amount of discharge at the meatus, accompanied by frequent desire to urinate, with inability to hold the urine when the desire comes on. In the mild cases involvement of the posterior urethra may be detected by means of the two-glass test, which is performed in the following manner: The patient passes the greater part of his urine into one glass and the re- mainder into another. If the disease is confined to the anterior urethra, the urine in the first glass will be cloudy from the pus washed out of the anterior urethra, while in the second glass it will be clear, as it consists of normal urine from the bladder passed through a urethra which has been washed clean of pus. Should the posterior urethra be involved, however, the pus from it, es- caping backward into the bladder, renders all the urine in it cloudy; the urine in both glasses therefore will be cloudy, the first a trifle more so than the second, as it consists of turbid urine from the bladder in addition to the an- terior urethral discharge which it washes out. Gonococci not infrequently enter the duct of the prostate gland, giving rise to an inflammation known as prostatitis, indicated by severe pain in the rec- tum which is generally intensified by defalcation. This inflammation may go on to the formation of an abscess which may burrow in various directions and burst into important near-by structures with serious results. The prostatic inflammation when chronic may give rise to an increase in the size of the gland. As the prostate surrounds the urethra just where it leaves the bladder, this increase in the size of the gland may interfere with the complete emptying of the bladder. The urine thus retained may decompose, become infected, and cause inflammation of the bladder. This inflammation may extend up the ureter and involve the kidneys, with serious results. When gonorrhoeal infection of the posterior urethra spreads along the vas deferens to the epididymis inflammation of that organ is set up. Such inflam- mation is known as epididymitis. About 5 per cent of all cases of gonorrhoea under treatment develop this condition. The patient first notices a slight ten- derness along the course of the epididymis. Later on the pain becomes very severe, and the scrotum or bag in which the testicles hang, becomes swollen and puffy. Constitutional symptoms may be severe and the patient’s temperature may rise to 104° F. With proper treatment after about a week of acute symp- toms the condition begins to subside. Although the patient may not complain of either pain or discomfort, the epididymis has not returned to its normal GENITOURINARY AND VENEREAL DISEASES 499 healthy condition, and the condition tends to become active again on the slightest indiscretion, such as getting out of bed too soon. The important effect of an epididymitis is that the inflammation often causes the caliber of the epididymis to become narrowed or obliterated, with the result that spermatozoa no longer are able to pass from the testicle to the urethra. In other words, the patient has become sterile on that side. If there has been epididymitis on both sides the patient becomes completely sterile. He still re- tains his potency but the ejaculated fluid, mainly prostatic secretion, is scanty in quantity and is- devoid of spermatozoa. Impregnation of the female is thus impossible, hence the unfortunate patient no longer can reproduce his species. An important sequel of gonorrhoea is stricture of the urethra. By this is meant a narrowing of the urethra by scar tissue at the site of an ulceration set up by the gonococcus. The narrowing of the urethra interferes with the free flow of urine and in time may cause complete retention or inability on the part of the patient to pass his urine. The treatment of typical gonorrhoea has been one of the open questions of medicine for a century. The ideal treatment would be to put a man to bed on a milk diet but this rarely is successful because few healthy men will keep it up for more than 5 or 6 days. In the acute stage a patient must be kept quiet and all sexual stimulation avoided. For the first week or 10 days, or even longer if the symptoms of inflammation are very marked, the diet should be light and easily digested. The following articles should be excluded: Ham, bacon, red meats, green veg- etables, fresh fruits of all kinds, condiments and spices, coffee, chocolate, cocoa, all alcoholic drinks, ginger ale, and similar effervescent waters. By mouth, sulfanilamide is of value, but methenamine, salol, and other urinary antiseptics are of questionable value. The testicles must be supported by a well-fitting suspensory bandage, which does not press upward on the urethra at the junction of the penis with the scrotum and thus interfere with the free drainage of the urethra. The head of the penis and the cavity of the foreskin must he kept clean by the frequent washing of these parts with hot water. The penis should be so dressed as to allow free drainage of the pus from the urethra, which at the same time must be kept from the cavity of the foreskin, the patient’s fingers, and clothing. These requirements are filled by a piece of gauze cut about 4 inches square, with a slit in the center through which the head of the penis is passed until the gauze rests in the groove behind the head. The foreskin then is drawn down over the gauze which protrudes from the orifice of the foreskin and catches the pus as it is discharged from the urethra. This dressing should be changed several times daily according to the amount of the discharge. If the foreskin is too short to hold such dress- ing in place, the end of the penis can be covered by a tobacco bag into which some gauze is placed. Never plug up the cavity of the foreskin with cotton or use cotton in a tobacco bag, as this interferes with the free dis- charge of pus and will favor the spread of the infection to the posterior urethra. To allay local pain and inflammation the penis should be immersed several times a day in hot water. A hot sitz-bath relieves to a great extent the feeling of soreness in the perineum. This bath is indicated if the patient has difficulty in passing urine. The heat has a tendency to relax the inflamed parts and the urine may be passed directly into the bath water. 500 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVT In all manipulations of the penis it is important to remember that the gono- coccus when transferred to the eyes will set up a severe inflammation which may result in permanent impairment of vision. As soon as a case of gonorrhoea comes under treatment the patient should be warned of the danger of infecting the eyes, the necessity of thoroughly wash- ing the hands after handling the penis, and the danger of contaminating towels, etc., and in this way causing the infection of others. The bowel should be kept freely open, preferably by vegetable cathartics, as saline purgatives are apt to produce more or less urethral irritation. To render the urine bland and nonirritating the patient should drink water freely, a glassful every hour during the day and whenever he wakes at night. For the prevention of painful erections the patient should be instructed to empty his bladder just before retiring, to sleep on his side on a hard mattress, with as little covering as possible. If awakened by an erection, he usually can obtain relief by emptying the bladder and by cold applications to the penis. When in a few days, as a result of the above constitutional treatment, the very acute inflammatory symptoms begin to subside, as is indicated by a dimi- nution and thinning of the urethral discharge, less pain on urination, and a decrease in the redness and swelling of the meatus, local treatment by injection, usually administered by the patient himself, may be instituted. If the urethra was a straight, smooth tube, gonorrhoea would be easy to treat, but there are along the urethra numerous little pockets in which the gonococci are buried and consequently are difficult to reach with any solution injected. Any injection should be gently done and the solution used should not be strong enough to produce more than a mere tingling; never a burning, painful sensation. Some men are very sensitive and the solutions must be diluted below the usual strengths. The solutions commonly used are mild or strong protein silver (argyrol, silvol, and protargol), mercurochrome, potassium permanganate, etc., the strengths of which are given later. Hand injections are given as follows: The patient urinates, wipes the meatus with a bit of gauze, gently inserts the nozzle of the syringe completely filled with the solution used into the meatus, the lips of which are lightly pressed together from side to side against the syringe; the solution then is forced in very slowly until there is a feeling of distention in the urethra. The solution should be held in the urethra 4 or 5 minutes, if not too uncom- fortable, before being allowed to escape. Injections should be made three or four or even five times daily, and while the fluid is being injected the patient should contract the compressor muscle of the urethra, much as if he were trying to hold back the contents of the bladder, in order to prevent the passage backward of any of the medication into the posterior urethra. While the solution is in the urethra the penis should not be massaged or rolled. If the foregoing treatment has been successful, in about 3 weeks the patient will have only a trifling urethral discharge, sometimes seen only in the morn- ing, with flakes or shreds in the urine. At this stage the injection should be changed to a solution of zinc sulfate one-half of 1 per cent in strength, administered daily. The patient should be warned against “stripping” or “milking” the penis in an endeavor to find a “morning drop.” Such manipulation irritates the inflamed mucous membrane of the urethra and retards healing. GENITOURINARY AND VENEREAL DISEASES 501 The patient’s urine should be watched daily by the two-glass method de scribed before and as soon as evidence of acute posterior urethritis develops all injections must be suspended. The patient should be kept very quiet and, if possible, put to bed for a few days, on a light, nutritious diet with the testicles properly supported. The bowel must be kept freely open as any accumulation of faeces in the rectum is liable to irritate the inflamed deep urethra and the prostate gland. Water should be taken freely. Hot water bags over the bladder or against the perineum relieve the pain in the deep urethra, as does the hot sitz-bath. If retention of urine occurs, it should be relieved promptly by the hot sitz- bath, or if that measure fails, by catheterization with a soft-rubber catheter. When the frequency in urination, bladder irritation, and other acute inflam- matory symptoms begin to subside, the local urethral treatment may be care- fully resumed and the patient allowed to be up and about. There are several complications of acute gonorrhoea which require special treatment. Balanitis is an inflammatory process attacking the mucous membrane of the head of the penis, and if accompanied by inflammation of the mucous membrane lining the foreskin, as it generally is, it is called halanoposthitis. It is caused by uncleanliness or by allowing smegma or gonorrhoeal pus to collect beneath the foreskin, where more or less inflammation is set up. The condition usually occurs in persons with a long tight foreskin, a condition which prevents retraction and proper cleaning of the parts. In treating this condition the parts must be kept clean by washing with hot water and separated by means of gauze wet in boric acid solution. When the acute process has subsided the parts may be treated by careful cleansing, drying, and the appli- cation night and morning of a dusting powder, such as thymol iodide. If the foreskin cannot be retracted, the space about the head of the penis may be washed out with hot water or physiological salt solution injected by means of a syringe. If there is considerable swelling of the parts the patient should be kept in bed with the penis enveloped by a wet dressing of physiological salt or boric acid solution. Soaking the entire penis in hot solution of boric acid, salt, or magnesium sulfate is useful. Phimosis and paraphimosis have been previously discussed. Epididymitis is one of the most frequent complications of acute posterior urethritis. The patient should be put to bed and given a brisk cathartic. The enlarged scrotum with its painful contents should be supported by a band of zinc oxide adhesive plaster 3 or 4 inches wide, which passes beneath the scrotum to each thigh, care being taken to have the thighs, legs, and inner borders of the feet close together before applying the plaster. If there is much hair on the thighs it should be shaved off to prevent pain when the plaster is removed. The scrotum, supported as described, is surrounded with gauze which is kept wet day and night with boric-acid solution or a saturated solution of magnesium sulfate. When the acute inflammatory symptoms have subsided, as a result of treatment, 20 per cent ointment of iehthyol is spread over the scrotum, which then is surrounded by a layer of lint or nonabsorbent cotton, over which is placed a piece of oiled silk or impermeable paper, the whole dressing being kept in position by a snug suspensory bandage. The patient is allowed to get up 4 or 5 days after all pain, tenderness, and temperature have dis- appeared. If he is allowed out of bed too soon a recurrence of the symptoms is likely. 502 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Prostatitis is an acute inflammation of the prostate gland and is a very com- mon complication of acute posterior urethritis. When infected the gland be- comes engorged with blood and swollen. This gives rise to a sense of fullness in the perineum and rectum, accompanied by irritation of the bladder. There is more or less pain in the prostate, as the faecal masses press upon it as they pass through the rectum during defsecation. The finger, covered with a rubber finger cot, if introduced into the rectum finds the gland to be enlarged, hot, and painful. A patient suffering from acute prostatitis should be put to bed immediately. All injections should be stopped and the urine rendered bland by copious drafts of water. The bowel should be moved freely every day, using vege- table cathartics for the purpose. Hot-water bottles over the bladder and against the perineum are useful. Much relief is obtained from the use of hot rectal irrigations of physiological salt solution given twice a day in the following manner: The patient lies on his side with the buttocks near the edge of the bed or table. An irrigating can filled with saline solution at a temperature not over 113° F. is so suspended that its lower end is about 1 foot above the patient’s hips. Two rectal tubes thoroughly lubricated with petrolatum are inserted very gently for a distance of about 3 inches in such a way that the outlet of one tube is near the gland. The fluid in the can is allowed to flow slowly into the rectum through this tube and out through the other which may have to be adjusted by withdrawing it a little to obtain a ready return flow. The posterior surface of the prostate thus is bathed with hot saline solution. Each treatment should last from 20 to 30 minutes. Gonorrhoeal ophthalmia is an infection of the eye caused by the accidential transference of gonorrhoeal pus from the genitals to the eyes by means of the fingers, dressings, or towels. It is one of the most serious complications of gonorrhoea as it may result in either partial or complete blindness. The symptoms usually appear within a few hours after infection and consist of redness and swelling of the conjunctiva, increased lacrimation, accom- panied by intense itching and a feeling as if a foreign body were under the lids. The conjunctivitis is associated with a profuse purulent secretion in which gonococci may be found on microscopical examination. The eyelids rapidly become red and swollen and the patient is soon unable to open the eye. The treatment may be divided into prophylactic and curative. Prophylaxis consists in thoroughly cleansing the hands after administering treatment or after handling the penis, the sterilization of all instruments and the immediate burning of all dressings which have been soiled by gonorrhoeal discharge. When a gonorrhoeal infection of an eye is suspected, the patient should be put to bed at once. If only one eye is affected, the sound one is covered with a glass shield to prevent its infection; this shield consists of a watch glass placed against a hole slightly smaller than the glass, in the center of a piece of adhesive plaster 4% inches square; the adhesive plaster is fastened to the skin about the eye and nose. It is advisable to leave a small area of the plaster nonadherent at the outer edge of the eye to permit the evaporation of moisture from the skin, which otherwise would collect within the shield. If a glass shield is not available the noninfected eye may be protected by covering it with a clean dressing and bandage. The infected eye must be washed out day and night with cold boric acid solution as often as any secretion accumulates. This flushing of the eye 503 GENITOURINARY AND VENEREAL DISEASES should be followed by the instillation of a drop of 10 per cent mild protein silver solution (argyrol, silvol) into the eye. In the intervals between the washings the eye should be kept covered with cold compresses—squares of gauze taken from a block of ice if possible, and changed every 2 or 3 minutes. These gauze squares should be used only once and then burned. Rubber gloves should be worn when giving these treatments. The eye is flushed out by means of an irrigator held high enough to allow the cold boric acid solution to flow out in a gentle stream. The patient should be gotten to a medical officer as quickly as possible. By the foregoing methods of treatment the hospital corpsman cannot expect to cure a gonorrhoeal infection, but by adhering to the treatment advocated he can relieve his patient of many distressing symptoms and shorten the time required by the medical officer to effect a cure. lymphogranuloma, venereum. This so-called “fourth venereal disease” is a subacute infectious condition involving chiefly the inguinal region, and also the prepuce, perineum, or vulva. It affects both men and women and is more common in tropical than in temperate climates. The cause of this disease is very probably a filtrable virus although the specific etiological agent has not as yet been demonstrated. Its transmission is by direct contact and almost exclusively by sexual intercourse. The dis- charges or secretions from lesions are infective. The disease is characterized by a small primary herpetiform lesion on the genitalia followed by inguinal lymphadenitis, usually with a multiple source of suppuration, and not infrequently associated with constitutional symptoms such as fever, anorexia, loss of weight, and prostration. It first manifests itself, from 1 to 4 weeks after exposure, by the appearance of a small, superficial ulceration on the external genitalia. The primary lesion is usually painless, and transient, disappearing in a few days, and may be so small as not to be detected. About 1 or 2 weeks later glandular enlargement occurs, the inguinals in male and the deep pelvic perirectal glands in the female. The enlarged glands vary in size from that of a small lime to that of an orange and may be involved singly or in chains, frequently bilaterally. Later central softening and suppuration occurs with the formation of indolent, discharging sinuses. Constitutional symptoms are variable. Fever, prostration, loss of weight, rheumatic affections and skin reactions have been observed. Elephantiasis of the penis and scrotum may occur due to blocking of the lymph spaces by in- guinal adenitis. The clinical syndrome of lymphogranuloma, venereum in women has been classified into three types: 1. Anorectal elephantiasis; 2. Rectal stenosis and stricture; and 3. Pelvimetritis with secondary rectal stricture. Various therapeutic measures have been recommended; physical, chemical, and surgical. A specific has not been found. Sulfanilamide has proved a valuable adjunct to therapy. It aids in the healing of ulcerations and helps draining buboes to cease. Good results have been obtained by the administration of iodine or antimony preparations. Roentgen irradiations and ultra-violet light have been used with variable, and in most instances inconclusive, therapeutic response. Frei antigen, diluted four times, and administered intradermally, at intervals of 5 days, has demonstrated encouraging results. In the diagnosis of lymphogranuloma, venereum the Frei antigen intracutaneous test is widely used. The antigen consists of pus from a bubo heated to 60° O. 504 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY for 2 hours on one day and for 1 hour on the following day. Intracutaneous injections of 0.1 cc in the forearm give rise in an infected person to an in- flammatory, dome-shaped area at least 0.5 cm. across with a small central in- filtrated papule. The reaction reaches its height after 48 hours. This disease must be differentiated from granuloma inguinale which is pri- marily a disease of the skin and not caused by a filtrable virus. Donovan in- clusion bodies found in the smear from the ulcer are characteristic of this condition. Because of the frequency with which they occur on the genitalia the two conditions next named are included here. Verruca accuminata, venereal. Venereal warts usually appear as small growths springing from the mucous membrane of the head of the penis or the inner surface of the foreskin, the region of the frsenum or the margin of the meatus. They are not necessarily venereal. Their cause usually can be traced to irritation incident to prolonged contact with inflammatory discharges. Thus, in the uncleanly with long fore- skins, in those suffering from gonorrhoea or chancroid, these growths are not uncommon. The redundant or phimotic foreskin which prevents proper cleans- ing is an important predisposing cause. The treatment consists of complete removal of the growth with possibly cir- cumcision, and this is the only reliable treatment. Herpes. This is a condition which is not venereal but which is mentioned in this connection because of its frequency and the liability of its confusion with venereal sores. This affection is characterized by the rather sudden appear- ance of small blisters upon a reddened base. Commonly they appear in or about the groove behind the head of the penis, involving both the head and the foreskin. The blisters quickly break leaving rounded or irregular erosions or ulcers which may run together forming a ring of ulceration around the penis. Sometimes these blisters are accompanied by intense pain, and the pain may precede the development of the blister. Herpes having once appeared is prone to develop again; at times the recur- rence quickly follows the first attack, new crops of blistersi forming as fast as the earlier lesions are healed. More frequently there is a distinct interval between the attacks. The lesions should be kept clean and protected with dressings of physiological salt solution which allows repeated examinations to be made for possible chancroidal or syphilitic infection. INSTRUMENTATION In genitourinary and venereal diseases. It is not expected that hospital corpsmen will give intravenous treatments or pass sounds, but they should be familiar with the instruments and their care, the preparation of the patient and his after care, and be able to do ordinary catheterization. The equipment for the administration of mercury, bismuth, and sulfars- phenamine by hypodermic injection and salvarsan, neosalvarsan, mapharsen, silver-arsphenamine and tryparsamide by intravenous injection, consists of measured glass syringes, measured glass irrigating cylinders, glass funnels, irrigating stands, rubber tubing, and needles of various sizes. The glassware should be boiled in distilled water or put through the autoclave, and it must GENITOURINARY AND VENEREAL DISEASES 505 be remembered that all this glassware breaks easily by rough handling and too quick changes of temperature. Needles should be cleaned immediately after use by washing and passing the stylet or wire through them several times. They should be dried by blowing ether through them, the stylet then inserted, and the needles put away in liquid petrolatum. They should be sharpened each time and should be sterilized by boiling for not over 10 minutes. In sharpening on the oilstone, the slope should be fiat and rather short and the edges hot rounded. The rubber tubing should be of the best quality red rubber, and when new tubing is used it should be soaked for 24 hours in a 4.5 per cent sodium- hydroxide solution, washed and boiled in distilled water for 4 hours, and then washed and boiled again for 2 hours, and finally washed again. This is neces- sary because rubber contains compounds which cause dangerous reactions. All of the arsenicals (salvarsan, neosalvarsan, mapharsen, silver-arsphena- mine, sulfarsphenamine and tryparsamide), should always be kept with all the wrapping around them, and they should never be kept together. This is espe- cially important with salvarsan and neosalvarsan, because to do so gives the danger of Injecting into the veins an unneutralized salvarsan, which means death in nearly all cases. Each should be kept away from light and heat. Just before mixing, the tube should be taken out of the package, Inspected, and put into 95 per cent alcohol to be sure it is not cracked. Never use a tube which is cracked or in which the powder is lumpy or discolored or which has an unusual odor when opened. The color of the different arsenicals is as follows: Arsphenamine.—Pale yellow to a lemon yellow; Neoarsphenamine.—Lemon yellow to canary yellow; Mapharsen.—White; Silver-arsphenamine.—Dark-brown; Tryparsamide.—White; Sulfarsphenamine.—Light yellow cast. Always note and record the name of product, maker, lot number, and dosage used, and the name of the patient to whom it is given. The water for intravenous use should be distilled always and never more than 24 hours before use. It should be sterilized not more than 24 hours before use. The same thing applies to physiological salt solution, of course. Salvarsan must be alkalinized before used. For this purpose 0.85 cc of 4 per cent freshly prepared sodium-hydroxide solution is used for each 0.1 Gm. of arsephenamine. This is the correct amount necessary to form the disodium salt of arsphenamine," the form which is best tolerated by the patient. The preparation of these drugs for administration is so important that it should be made by, or under, the direct supervision of a medical officer. The following principles should be kept in mind: Salvarsan is permitted to stand for 30 minutes after preparation prior to administration. The solution may stand as long as 3 hours, without undergoing any increase in toxicity, provided it is protected from the air, not shaken, and the temperature does not exceed 30° C. Mapharsen is relatively stable and may be given as long as 1 hour after prepa- ration. All of the other arsenicals should be administered as soon as prepared and never longer than 20 minutes after preparation. All of these drugs should be given slowly except mapharsen which, in contradistinction to the others, should be given rapidly. All of these arsenicals are given intravenously except sulfarsphenamine which is injected intramuscularly. No salvarsan or neosalvarsan should be given without resting and fasting before and after for several hours. 506 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Always have convenient and ready, syringes and needles, with ephedrine hydro- chloride and ampules of sodium thiosulfate, in case of bad reactions. Mercury is occasionally given by mouth in the form of mixed treatment: (Bichloride of Mercury, 1 grain; Potassium Iodide, 2 drams; water or other vehicle, 3 fluidounces;) 1 teaspoonful three times a day; or mercury with chalk, 1 grain, three times a day. The best method is probably by inunction of about 4 Gm. of strong mercurial ointment once daily on a different part of the nonhairy portion of the body, using the inner side of the thighs, inner side of arms, and between hip and arm pits, never using one place the second time until all the other places have been used. The salicylate of mercury, 1 grain in 1 cc of liquid petrolatum, or the succinimide, one-sixth grain in 1 cc of water, are on rare occasions given intramuscularly. Bismuth should be administered only by intramuscular injection and the subsalicylate is probably the best form. The dose is 0.2 Gm. of subsalicylate (not 0.2 Gm. of metal- lic bismuth), at 5 to 7 day intervals. A course is 6 to not more than 12 injections. The solutions of mercury and bismuth for intramuscular injection, should be shaken up to the last second, as they tend to settle out quickly. In injections into the buttock always draw back the plunger of the syringe to see if any blood shows, which indicates the needle is in a vein, before injecting. If blood shows, pull the needle out and reinsert. Inject slowly. Of the urinary system. For the most part this is done through the urethra and through the ureters with instruments called catheters, sounds, bougies,, filiforms, cystoscopes, ure- throscopes, urethral dilators, and urethrotomes. The first consideration is the care of these instruments. Some of them are rubber, some woven silk with wax covering, some silver, some steel or brass with silver or nickel plating, some whalebone, and some with glass lenses or prisms cemented in them. All should be handled carefully and not scratched, bent, or dented. Metal instruments should be kept clean and dry and polished with nonscratching material, and well greased with vaseline when in moist climates, as on shipboard. All metal instruments except cystoscopes may be boiled for not more than 10 minutes in distilled water. Rubber and whalebone catheters may be boiled for not more than 10 minutes. The woven, wax-covered instruments as well as the cystoscopes should never be boiled, but should be sterilized by thorough washing in soap and water and soaking for at least 20 minutes in formaldehyde or oxcyanide of mercury solution. The metal instruments must never be soaked in bichloride of mercury solu- tion. Alcohol and phenol solutions tend to injure rubber or wax. The sizes of instruments to be passed into the urethra or on into the bladder or by the ureters up to the kidneys are indicated by three different systems of numbering—French, English, and American. For practical purposes the French only should be considered. These have a scientific basis and the number indicates the number of millimeters (a millimeter is one twenty-fifth of an inch) around the instrument. Thus, a No. 25 sound would be exactly 1 inch in circumference. The instruments are usually made only in even sizes from 10 to 32, inclusive, and in both odd and even sizes from 4 to 10. The latter are used almost exclusively in ureteral work. For urethral or ureteral catheterization the patient should lie on his back in an easy position and breathe with the mouth open and the belly muscles relaxed. In cystoscopic and urethroscopic work the patient lies on the back with the knees and thighs Hexed and supported, and the operator stands GENITOURINARY AND VENEREAL DISEASES 507 between the legs. The whole penis should be cleansed with soap and water and bichloride of mercury solution, or, better, with full-strength alcohol; although the latter may sting a little, it is perfectly safe. No instruments should be passed into the urethra without a lubricant. A tragacanth or similar jelly should be used for cystoscopes and routine work where the treatment is with watery solutions. (See formula on p. 240.) Glycerin is also a fairly good lubricant. However, sterile liquid petrolatum should always be used for difficult catheterizations and the passing of sounds. The oil is warmed and slowly injected with a syringe held tightly against the meatus. In cystoscopic work and where difficulty is expected it is a great advantage to give a hypodermic injection of morphine % and atropine %50 grain about three-quarters of an hour before and to inject vigorously a syringeful of 4 per cent procaine or novocaine solution 5 minutes before and repeated just before starting. Gentleness is of the greatest importance in passing instruments in the male urethra. Rough handling or overdilation will often give fever and chills, which reaction is known as a urethral chill. Men have been killed by rough instrumentation. For the inexperienced the best catheter to try in a difficult case is a woven, waxed one. Start with a No. 20, and then a No. 16, and then a No. 12, and finally a No. 10. It will follow the curve of the urethra better if it is warmed to a little above body temperature. In ordinary cases a No. 20 rubber catheter passes easily. The penis should always be put on a stretch. In cystoscopic work in America an irrigating outfit with sterile water or boric acid solution is used at room temperature. After use all instruments should be thoroughly rinsed off and sterilized in the appropriate way. After cystoscopic study and difficult instrumentation a patient should always lie down for a few hours and drink plenty of water, as pains, chills, and fever often follow in these cases. If a man cannot urinate and has a great deal of urine in the bladder and a catheter is successfully passed, do not draw off more than 600 cc at first. Leave the catheter in place and fix it with adhesive strips and then clamp the catheter with a hsemostat and let out about 150 cc per hour until the bladder is empty. This will lessen the shock that accompanies emptying an overstretched bladder. Sometimes a man can be made to urinate naturally by some of the following means: Applying a hot towel to the pubis; immersing the penis in warm water; letting water run in his hearing; leaving him alone for a while; letting him sit in a tub of hot water; giving a good warm enema; and giving plenty of water to drink. DOSES, DANGERS, AND STRENGTHS 0E SOLUTIONS USED IN GENITOURINARY AND VENEREAL TREATMENT 1. Argyrol (mild protein silver).—Used in solutions of 5 to 10 per cent as an injection. 2. Alum.—Sometimes used in the treatment of chancroids. It is dried, pulver- ized, and sprinkled on the ulcer. There is no danger, but it may sting very sharply. 3. Bismuth subsalicylate.—'This is given in doses of 1 or 2 cc of the sub- salicylate, each cc representing 0.18 Gm. of metallic bismuth suspended in sterile olive or peanut oil. Care must be taken in the administration to be sure the needle is not in a vein or artery. This substance injected into a vein 154294°—39 33 508 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY is apt to be fatal. If injected into an artery it may produce necrosis of the structures supplied by the vessel. 4. Camphor.—Given in doses of 0.065 Gm. (1 grain) in cases of irritation of the neck of the bladder. There is no danger in this dosage. 5. Copper sulfate.—Used in the form of crystals or in solutions of 10 to 25 per cent strength for application to ulcers. It is painful and should be pre- ceded by procaine locally. There is no danger, but if it should be swallowed, milk should be given and the stomach lavaged. 6. Formaldehyde.—Used in full strength to touch up ulcers. To sterilize instruments soak them in 5 to 10 per cent solution for 20 minutes and always rinse off with sterile water before using. If accidentally swallowed, give milk and wash out stomach. 7. Iodides.—These are given in the form of sodium or potassium iodide in saturated solutions when 1 drop equals approximately 1 grain. The dose is from 5 drops to 100 drops by mouth. The danger is very little and the signs of toxicity are headache, watering of eyes and nose, and breaking out in small boils. Sodium iodide is also given intravenously in a 10 per cent solution; dosage from 20 to 100 cc. A slight burning of the throat sometimes occurs when given in this way. 8. Mapharsen.'—Always given intravenously in sterile water so that each 0.01 Gm. of the drug is represented by about 2 cc of water. The dose is not more than 0.06 gram. 9. Mercurochrome.—One per cent for urethral and bladder injections and also for intravenous use, 10 cc and even 25 cc being given in desperate cases. Should be freshly made. Ten per cent strength is used for touching ulcers. 10. Mercurial ointment, strong.—Used as an inunction in treating syphilis; should be diluted with equal parts of vaseline or lanolin. Rub a piece weighing 4 Gm. into the skin on a nonhairy portion of the body at night and wipe off with kerosene in the morning. Change the spot rubbed every night. 11. Mercurous chloride mild, ointment of (calomel ointment).—One-third strength made up in lanolin for venereal prophylaxis. 12. Mercury bichloride (bichloride of mercury).—Used in a strength of 1-1,000 for sterilizing the skin, nonmetallic instruments, etc. Used by mouth in the treatment of syphilis, in solution so that a dram dose equals one-thirty second to one-twelfth grain. Rarely given by intramuscular injections. 13. Mercury oxycyanide.—One to 1,000 solution for soaking instruments. Noncorrosive and metal instruments are not harmed. 14. Mercury protoiodide.—One-sixth to one-third grain tablet three times a day in the treatment of syphilis. 15. Mercury salicylate.—One grain in 1 cc of liquid petrolatum injected deep into the buttock once a week in treating syphilis. 16. Mercury succinimide.—Two-fifths to three-fifths grain in 1 to 3 cc of water injected about once a week deep into the buttock in treating syphilis. The dangers of mercury when absorbing too much in medication are ptyalism or salivation (sore teeth and excessive secretion of saliva) and irri- tation of the kidneys. Stop at once and give a mild purge of magnesium sul- fate. The emergency treatment in cases of accidental swallowing- of mercury should be borne in mind always. 17. Methenamine.—Given by mouth in dosages of 0.3 to 1 Gm. about four times a day for neutralizing irritating urine. Should be combined with sodium acid phosphate, as the urine must be acid for it to be of value. The sign of 509 GENITOURINARY AND VENEREAL DISEASES excessive dosage is irritation and a slight smokiness of the urine. It should be stopped at once. 18. Neosalvarsan.—Always give intravenously in sterile water so that each 0.1 Gm. of the drug is represented by about 2 cc of water. The dose is from 0.3 to 0.6 Gm. and it requires no neutralization. 19. Phenol.—Used in full strength to touch ulcers. Sometimes in weak solutions of 1-100 to 1-200 as a dressing; also to sterilize instruments. When used in too large a dressing enough may be absorbed by the skin to produce irritation of the kidneys, the sign of which is smoky urine. In accidents where strong phenol is spilled on the skin use alcohol locally. Where it has been swallowed use magnesium sulfate solution and wash out the stomach. 20. Potassium acetate.—Used by mouth in dosages of 2 to 4 Gm., in irritation of the bladder. 21. Potassium citrate.—Used by mouth in dosages of 1 to 1.5 Gm., in irrita- tion of the bladder. 22. Potassium permanganate.—Used for injections and bladder irrigations. Start with a solution strength of between 1-10,000 and 1-8,000 and increase the strength cautiously. 23. Procaine and novocaine.—Used in y2 to 1 per cent solutions for local anaesthesia. To inject in the urethra, a 4 per cent solution is used. There is practically no danger in these strengths. 24. Protargol (strong protein silver).—Used in strengths of % to 1 per cent as an injection. The silver solutions should be fresh and they should be kept away from light. There is little danger in the strengths noted. To neutralize where irritation results or where swallowed accidentally give saturated solution of table salt and wash out the stomach. 25. Salvarsan.—Always give intravenously in solution so that each 30 cc equals 0.1 Gm. Always neutralize with sodium hydroxide because it is acid. The doses are from 0.2 to 0.4 Gm, 26. Silver nitrate.—Used in the form of sticks to touch ulcers or in 25 to 50 per cent solution for the same purpose. It may be used in solution for urethral injection or into the bladder but should not be used stronger than 1-10,000 to 1-5,000 solution at first. Its action is neutralized by salt solution. 27. Silver-arsphenamine.—Always given intravenously in sterile water or physiological salt solution so that each 0.1 Gm. of the drug is represented by about 7 cc of water. The dose is 0.3 Gm. or less. 28. Sulfarsphenamine.—Always given deep into the muscles of the buttock, in the smallest amount of water in which it will dissolve. The dose is from 0.2 to 0.4 Gm. and this will dissolve in about 1 cc of water. 29. Silvol.—Same as argyrol. 30. Sodium acid phosphate.—In dosages of 0.5 Gm., to acidify the urine. Usually combined with methenamine in the dosage of 0.5 Gm. each. 31. Sodium thiosulfate.—One gram in 10 cc of water intravenously for mer- cury, bismuth, arsenic (salvarsan and neosalvarsan), silver, and lead poison- ing. One gram in 10 cc of cold (never boil the solution) sterile water. 32. Sulfanilamide.—Of value in many infections. It is given by mouth in doses of 20 to 120 grains a day. Due to idiosyncracies to the drug shown by many patients, it should never be given unless the patient is under medical supervision. 33. Tincture of hyoscyamus.—Given in irritation of the urinary tract in dosages of 10 to 15 drops. 34. Tryparsamide.—Given in 3 Gm. doses in 10 cc of water intravenously. 510 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY NOMENCLATURE OF TERMS RELATING TO THE ANATOMY, DISEASES, IN- JURIES, CONDITIONS, AND INSTRUMENTATION OF THE MALE GENITOURI- NARY SYSTEM Adenopathy.—Enlargement of lymphatic glands. Alopecia.—Natural or abnormal deficiency of hair. Balanitis.—Inflammation of the glans penis (head of the penis). Balanoposthitis.—Inflammation of the glans penis and the prepuce (foreskin). Bougie.—A slender sound with a bulb-shaped tip. Bubo.—Inflammatory swelling of a lymphatic gland, particularly in the axilla or groin. Castration.—Complete removal of the testes. Catheter.—A tubular instrument used to draw urine from the bladder or kidney. Chancre.—The primary lesion of syphilis no matter where it appears. The word is from the Greek and literally means “a crab,” but its general meaning now is an ulcer. The word “cancer” is also from the same Greek word. Chancroid.—A soft, nonsyphilitic sore. Also called “soft chancre.” Chordee.—Inflammation of the corpus spongiosum of the penis resulting in a painful semierection and bending downward of the penis. Clap.—Same as gonorrhoea. Condyloma.—A wart-like excrescence near the anus or Vulva, especially the flat, moist papule of secondary syphilis. Corona.—The crown-like rim surrounding the base of the glans penis. Cystitis.—Inflammation of the urinary bladder. Cystoscope.—An electrically-lighted instrument for examining the interior of the bladder. Dermatitis exfoliativa.—A severe, obstinate, scaly rash sometimes resulting from poison- ing by used in treating syphilis and usually associated with loss of the hair and nails. Ejaculation.—The sudden expulsion of the seminal fluid. Epididymis.—Oblong, convoluted body attached to each testicle. Epididymitis.—Inflammation of the epididymis. Epispadias.—A congential malformation in which the urethra opens on top of the penis. Erection.—The condition of being made rigid and elevated. Eroding.—Eating away; destroying. Filiform.—Thread shaped; an extremely slender bougie. Frcenum.—The fold on the lower surface of the glans penis by which it is attached to the prepuce. Clans.—The head, or terminal end, of the penis. Gleet.—An old, chronic form of gonorrhoeal discharge. Gonococcus.—The same as Neisseria gonorrhoeas. Gumma.—A soft, tumor-like swelling occurring in the third stage of syphilis. Hwmatocele.—Effusion of blood into a cavity, especially into the ones containing the testes. Hermaphrodite.—An individual who partakes or appears to partake of both male and female characteristics. Hydrocele.—A collection of excess serous fluid in the sacs containing the testes. Hypospadias.—A congential malformation in which the urethra opens on the under side of the penis. Inguinal rings.—Openings in the wall of the abdomen through which the spermatic cord passes; known as internal and external. lodism.—A condition resulting from prolonged administration of iodides characterized by headaches, running nose, watering eyes, and skin eruptions. Kohlman dilator.—An instrument passed into the urethra and then made to expand, thereby stretching strictures. Locomotor ataxia (tabes dorsalis).—A degenerative condition of the spinal cord resulting from syphilis that produces difficulty in walking, etc. Meatus or meatus urinarius.—The external opening of the urethra. Mucous patches.—Syphilitic lesions or sores in the mouth and about the genitalia and anus, usually occurring in the secondary stage. Orchitis.—Inflammation of the testicle. Paraphimosis.—The retraction of a narrow or inflamed foreskin behind the glans penis which cannot be replaced. Paresis, or general paresis.—A chronic, degenerative disease of the brain resulting from syphilitic infection and causing insanity. Penis.—The male organ of copulation or sexual intercourse. 511 GENITOURINARY AND VENEREAL DISEASES Perineum.—The space between the anus and genital organs forming the floor of the outlet of the pelvis and occupied hy the terminations of the rectum, the urethra, and the root of the penis, the vagina in the female, and various muscles, fasciae, vessels, and nerves. Phagedenic.—Same as eroding. Phimosis.—Tightness of the foreskin so that it cannot he drawn hack over the glans penis. Posthitis.—Inflammation of the foreskin. Prepuce.—The foreskin. Prerenal.—In front of the kidney. Prostate or prostate gland.—A gland surrounding the neck of the bladder and the urethra and in which the secretion of the testes is diluted. Prostatitis.—Inflammation! of the prostate. Ptyalism.—Excessive secretion and discharge of saliva, especially from the administra- tion of too much mercury. Pubis.—The bony arch above the root of the penis. Pyelitis.—Inflammation of the pelvis of the kidney. Pyelonephritis.-—Inflammation of the pelvis of the kidney with kidney involvement. Pyonephrosis.—A condition in which pus is present in the pelvis of the kidney. Raphe or raphe scroti.—The seam or ridge in the middle of the scrotum. Resectoscope.—An instrument for resecting a portion of the prostate through the urethra. Rupee.—The folds or wrinkles of the scrotum. Salivation.—Same as ptyalism. Scrotum.—The sac or pouch which contains the testes. Secondaries.—The symptoms of the secondary stage of syphilis. Semen.—'The secretion containing the spermatozoa produced by the male generative or- gans ejaculated during coition. Seminal vesicles.—Two small sacs situated at the base of the bladder serving as reser- voirs for the storage of semen. Seminal vesiculitis.—Inflammation of the seminal vesicles. Sound.—An instrument used to measure the size of or to dilate the urethra or ureters. Spermatic cord.—The ,cord-like structure containing arteries, veins, lymphatics, and the vas deferens or ductus deferens, that suspends the testicle. Stricture.—An abnormal narrowing of a canal, duct, or passage. Sulcus.—A groove, trench, or furrow; the sulcus behind the glans penis. Tertiaries.—The symptoms of the third stage of syphilis. Testicle.—The male organ producing the spermatozoa. Treponema pallidum.—The microorganism causing syphilis. Ureter.—The tube which conveys urine from the kidney to the bladder. Ureteritis.—Inflammation of the ureter. Urethra.—The membranous canal or tube through which urine passes from the bladder to the external air. In the male it also conveys the seminal ejaculations. Urethritis.—Inflammation of the urethra. Urethroscope.—An instrument used for examining the interior of the urethra. Urethrotome.—An instrument used to cut strictures of the urethra. Varicocele.—Enlargement of the veins in the spermatic cord. Vas deferens or ductus deferens.—The excretory duct of the testicle and carrying the spermatozoa from the testes to the seminal vesicles. Section 4.—THE PREVENTION OF VENEREAL DISEASES Because of their prevalence, ready transmissibility, and far-reaching effects, the venereal diseases are a menace to home and to family life. In one way, and one only, can infection with venereal disease be prevented, and that is by completely avoiding promiscuous sexual intercourse. Clean living, the in- dulgence in athletic sports which promote health and occupy the mind, and the avoidance of alcohol during hours of relaxation are important factors in the prevention of venereal disease. The principles underlying the control of veneral diseases differ in no way from those concerning the prevention of other communicable diseases. The 512 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY immediate, practical problem is to prevent the further spread of venereal infection. The preventive measures for venereal diseases may he summed up as follows: A. Control through the community. 1. Segregation and regulation of prostitution. 2. Suppression of clandestine and occasional prostitution. 3. Isolation and/or treatment to shorten the period of infectivity. 4. Suppression of questionable resorts. B. Control through the individual. 1. Social approach—disuasive measures. a. Ethical and moral instruction. h. Instruction in effects of disease on individual and on his social relationship. 2. Recreational approach—substitutional measures. a. Occupation to engage interest, fill leisure, absorb energies, and proper social contacts. 3. Disciplinary approach. а. Preventing exposure by restriction of liberty. б. Placing localities out of bounds. c. Denial of liberty to disease carriers. d. Segregation and treatment of infected persons. e. Penalties for disabilities of venereal origin. /. Punishment for failure to use prophylaxis. 4. Personal prophylaxis. a. Mechanical appliances. &. Medicinal agents —at disinfecting stations. —in portable form. The use of both chemical and mechanical prophylactics against venereal infection has been advocated in the Navy for many years. The effectiveness is high when these measures have been used early and properly. Those who expose themselves to the danger of contracting a venereal disease should be urged to use immediate prophylaxis. On January 9, 1909, the Secretary of the Navy issued an order to the service which required promulgation of information regarding venereal disease to the men of the service, and directed that facilities for prophylaxis be made avail- able. Since 1914 personnel of the Marine Corps, and since 1916, personnel of the Navy and Marine Corps, have been penalized by losing their pay and time wThile absent from duty because of a venereal disease, which was contracted as a result of their own misconduct. The oldest and best prophylactic measure is the mechanical appliance known as the sheath or condom. This is usually made of rubber and is for sale in most Ship’s Service Stores. Government regulations specify high requirements of rubber prophylactics and shoddy materials are not sold by reliable firms. Two simple tests that can be applied to rubber goods sold by Ship’s Service Stores are quoted from the Bureau of Standards specifications: “E-3. Inflation test.—The prophylactics shall withstand inflation to a length of 24 inches for a period of 1 minute, and when inflated shall show no porosity or thin spots. “E-4. Oil test.—One hour after application of mineral oil of medicinal grade the prophylactics shall withstand inflation to a diameter of 6 inches for a period of 1 minute. It is not essential that the shape of inflation be uniform.” GENITOURINARY AND VENEREA! DISEASES 513 In the use of a condom it is essential that some space remain at the end to prevent any chance of undue stress or strain on the rubber. Upon removal care must be exercised so as not to increase the chance of contamination from the sheath. Then immediate washing of the penis and surrounding parts and the proper application of the contents of a prophylactic tube or 33 per cent calomel ointment will prevent many a case of venereal infection. Prophylactic tubes, often called Sani tubes, are given to anyone on request at the sick bay, dispensary, or prophylaxis station. Medicinal or chemical prophylactic treatment used immediately or within the first hour after exposure is very efficacious in preventing the development of venereal infection. Although its value rapidly diminishes from then on and is greatly reduced after 8 hours have elapsed, men returning to the ship or station within 8 hours following exposure should be urged to avail themselves of chemical prophylaxis under supervision of a hospital corpsman, A careful record should be kept showing the name and rating of the person treated, the hour of treatment, the hour and place of exposure, and the name and address of consort. The method of prophylaxis used in most Navy prophylaxis stations is to have the man urinate and then thoroughly wash the penis, scrotum, and pubic region with liquid soap and warm water. One-half a syringeful of 1 per cent solution of strong protein silver (protargol) or 10 per cent solution of mild protein silver (argyrol, silvol) is injected gently into the anterior urethra and allowed to flow out; the remainder is then injected and held in the urethra for 5 minutes. When the parts that were washed have thoroughly dried, the penis, scrotum, thighs, and pubic region are liberally annointed with 33 per cent calomel ointment in lanolin. The ointment should be well rubbed in for at least 10 minutes, paying especial attention to the corona and region of the frsenum. The clothing should be protected with a temporary dressing and the ointment allowed to remain for 12 hours. The Navy prophylactic tube consists of a pliable, metal tube with a tip which can be inserted into the urethra. One half of the contents is injected into the urethra and the other half is used externally. Use of the contents immediately before cohabitation is a valuable preventive measure. The for- mula of the contents of the Navy prophylactic tube is as follows: Mild mercurous chloride (calomel) 33 Camphor 2 Phenol 3 Anhydrous lanolin 39 Benzoinated lard 20 Beeswax 3 Bach tube contains 7.5 grams of this ointment. As a result of a 4-year investigation undertaken at the U. S. Naval Medical School, Washington, D. C., to compare the efficacy and suitability of the many substances considered of possible value in the immediate chemical prophylaxis of venereal infection there has been reported a formula that will probably prove to be superior to and more effective than any previously used. The value of the various prophylactic measures in preventing venereal in- fection is well shown by the reduction in the total admission rate for syphilis, gonococcal, and chancroidal infections from 193.52 per 1,000 in 1909 to 63.90 per 1,000 in 1937. During this same period the admission rate per 1,000 for gonococcal infections was reduced from 102.51 to 43.85, for chancroidal infec- tions from 27,51 to 7.82, and for syphlitic infections from 25.81 to 11.08. 514 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY It should always be remembered that diseases that have attacked more than half the men of the country during youth, diseases that bring misery to thousands of children and suffering to hundreds of thousands of women innocently infected, and that are incurred almost exclusively through promis- cuous sexual intercourse, are diseases to be avoided. It should also be remembered that the man who practices promiscuous cohabitation almost invariably contracts one of the venereal diseases, sooner or later, in spite of every precaution. And if sufficient moral stamina to resist sexual tempta- tion is not possessed, then it must be remembered to take prophylactic treatment as soon as possible after exposure. References Syphilology.—Stokes. Practice of Urology.—-Young. Hospital Corps Handbook, U. S. Navy, 1923 Section 5.—INDUSTRIAL MEDICINE AND INDUSTRIAL HAZARDS Industrial Medicine is that branch of medicine which deals with the pre- vention of diseases and injuries among industrial workers. Strictly speaking, industrial medicine has become of such importance in late years, that it is not now limited to workers, but endeavors to promote good health and in- crease the life span of the entire people. Its purposes or aims are to insure good health, the prevention of avoidable accidents, to alleviate unnecessary suffering and thereby provide contentment and promote more efficient work. It further deals with the rehabilitation of diseased and injured persons and reclassifies them to work in such posi- tions as their disabilities will permit, thereby obviating the necessity for their becoming public charges and insuring them a livelihood. Industrial Medicine is akin to Hygiene and Sanitation and Preventive Medi- cine, but spreads out to embrace accident prevention as well. Its aims are accomplished by endeavoring to reduce the health and accident hazards to a minimum by education, safety devices and precautions, periodic physical exam- inations, cooperation of employees, and by the passage of laws for the protection of the workers. The need for the development of this branch of Medicine is apparent to all, when it is known that in the sixteenth century the average life expectancy of the working man was 22 years, as compared to 44 years for those of the upper classes. The working men were really slaves. They worked from 12 to 20 hours daily, 7 days a week. They were subjected to forms of health hazards about which little or nothing was known. The death of the men was considered a natural course of events. The value of Industrial Medicine to the workers has been clearly manifest. Today, the average working man in industry may well expect to live to the age of 50 with still a better outlook for the future when the hazards to health and accident are better understood and safety measures are developed and perfected to protect against such hazards. In this country today, every employee is protected by laws which require that certain standards of protection be maintained against health and accident hazards. Compensation laws are in force to require the payment of disability benefits to those incapacitated by accident or disease which were connected with their employment. INDUSTRIAL, MEDICINE 515 A National Safety Council was established in 1912 and its slogan of “Safety First” has become a by-word in all homes. In 1914 a health section composed largely of Industrial Surgeons, was incorporated as part of the association. Thus the need of medical advice in industry was established. It is a well- recognized fact that the “human machine” constitutes a very definite hazard to health and accident. The medical man therefore must form a definite part of any industrial organization. Today, the National Safety Council in America is one of the greatest organizations of its kind and by its help has put the working conditions in this country on a very high plane and the industrial worker has reaped the benefits. Today, every industry in this country, no matter how large or how small, has its medical staff, or its equivalent. Many large industries have their own hospitals and medical staffs; others have contract surgeons but all are required in one form or other to give medical attention to the employees under them. The Government having passed such laws must therefore lead the way in protecting its own employees. The United States Navy is one of the largest of the industries maintained by this Government. An organization has been set up in the Navy to protect its personnel, both civilian and naval. A safety engineer is provided, who acts directly under the Assistant Secretary of the Navy. He has supervision of the safety precautions taken to protect the civilian employees in the navy yards, ammunition depots, torpedo stations and the like. He is also a consultant in all matters pertaining to safety aboard ships, at training stations and other Navy Department activities. A naval medical officer is assigned to his office for the purpose of consultation in all matters pertaining to health and safety and to cooperate in devising means by which health may be protected and accidents prevented. Aside from this particular medical officer, all medical officers, dental officers, members of the Hospital Corps and nurses form the balance of the medical staff of this organization. It is essential that each one of these members know and understand the hazards to be encountered in the Navy, the steps to be taken to protect against injury and disease, the treatment of diseases and injuries arising therefrom and the organization of the medical personnel for such purposes. Naval medical personnel are required to perform duties ashore, at sea, in foreign countries, in the air and under the sea. In each of these places a variety of health hazards exist. It is therefore necessary that this personnel have a thorough knowledge of the industry to which they are attached, the hazards presented, the methods of prevention and the treatment of all injuries occurring. An occupational hazard is any condition, existing in the trades, which will lead directly or indirectly to disease or injury. No method can be devised for classifying hazards for they are too numerous. However, they may be grouped under the following headings: 1. Those hazards present in the working force by reason of physical defect. 2. Those hazards found in the working places, including hygienic and sani- tary defects, mechanical defects of machinery, lack of safety education and the like. 3. Those hazards presented by carelessness of employees. A large majority of accidents are due to this cause alone. 4. Those hazards due to unforeseen influences such as lightning, earthquake, tornado, and the like. Industrial accidents may be prevented by an understanding of the hazards pre- sented in the foregoing groups, by: 1. Thorough physical examination of all new employees, prior to their actual employment, to discover potential physical defects which would render the em- 516 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY ployee a hazard to himself or others. An example of this would be a person with manifestly defective vision being employed as a machinist. Physical examina- tion of all regular employees periodically, to determine their ability to continue working at their trade and to reclassify them to less hazardous work or to re- tire them, as found necessary in individual cases. Repeated examination of all employees engaged in hazardous trades such as sandblasting, painting, chrome plating, T. N. T. handling, and others, to determine any possible systemic effects present as a result of their trade. 2. A constant and thorough inspection of all shops and working places by the safety engineer, the medical officer, and their assistants to determine the causes of accidents, the hazards to health and the immediate correction of these faults. Education of the employees by means of lectures, motion pictures, posters, and such, will further accomplish much in the line of prevention. 3. The prevention of carelessness by indoctrination of all employees with the spirit of prevention and building up a spirit of cooperation and high morale among them. If necessary, disciplinary measures should be taken when workers are habitually careless. 4. Providing, in so far as is possible, means of protection and escape in cases of disaster. An exact classification of occupational diseases is difficult, in view of the great number and types of diseases presented by the industry. There is such a great variety and number of skin diseases in the trades that they are generally grouped under the heading of Occupational or Trade Dermatoses. It is suf- ficient to state here that practically all diseases and injuries may be associated with industry. To successfully carry out the objects of Industrial Medicine the medical per- sonnel of the Navy must know: 1. The organization of a safety unit of an industry and the duties of each of the personnel. 2. The hazards to health and accident presented by the particular industry to which they are attached. 3. The methods and means of protection to be established against the en- countered hazards. 4. The treatment of industrial diseases and injuries. 5. The laws relating to compensation and treatment of sick and injured per- sonnel, including a knowledge of the necessary reports and returns to be sub- mitted in such cases. For the purpose for which this book is intended, it seems sufficient to give the hospital corpsmen a general idea of the organization, hazards, protection, treatment and laws as related to the Navy, rather than to try to discuss In- dustrial Medicine as a whole. This may well be done by discussing the safety organization and its associated duties at a navy yard, for those in force at navy yards are applicable to a greater or lesser degree throughout the Navy. These will be considered in the order given. Organization. At all navy yards, the Commandant is the head of the organization. He is responsible to the Navy Department for the protection of the employees, as well as the naval personnel, under his command. He is familiar with the nature of the work being performed by the employees at his station and the health and accident hazards presented. Accordingly, he appoints, as the work- ing head of the organization, a safety officer or a safety engineer, as he is bet- ter known. The safety engineer must be of sufficient rank and service to have INDUSTRIAL MEDICINE 517 become familiar with the various trades in a navy yard, a knowledge of machinery, a man of cooperative ability and well liked, and having sufficient knowledge of safety devices and appliances to intelligently make inspections and recommend proper protective measures. His duties are primarily, to pre- vent accidents and promote healthy working conditions. It is his duty to inspect all working places, make a general survey of all mechanical conditions and to recommend the addition of all necessary safety appliances for the pro- tection of the workers. He must make daily inspections of the shops to see that these safeguards are in working order and are being used. He must inves- tigate all major accidents in order to determine the cause and recommend methods to prevent a similar accident. There should be full cooperation between him and the medical officer. All improvements come under his supervision. The Commandant further assigns a medical officer to act as advisor to the safety engineer. The medical officer must be of the same qualifications as the safety engineer, with the addition that he must be thoroughly versed in the diseases connected with Industry. He need not have a thorough knowledge of machinery but must understand sufficient of the operation of the various machines to intelligently advise the safety engineer in matters relating to the development of safety devices. The duties of the medical officer are as follows, and in this connection it is well for members of the Hospital Corps to under- stand the nature of these duties in order that they may be of assistance to him in the performance of these duties: The medical officer is the safety engineer of the human body. He acts as consultant to the safety engineer in all matters pertaining to the general wel- fare and health of the employees. Hygiene and sanitation are his important duties. He must interest himself in the employees and instruct them in the every day principles of personal hygiene and self preservation. He must instruct the employees in safety measures and encourage them to cooperate in protective measures. They must be made “safety conscious” or “safety minded”. The morale must be kept up. A high morale leads to fewer accidents and better workmanship. The medical officer must Inspect all working places in order to have a better understanding as to the actual conditions under which the men work. He must make appropriate recommendations to improve deficiencies noted and must then see that these recommendations ai*e carried out. He must personally make all physical examinations of prospective em- ployees or see that the physical standards for employment are adhered to. He must make physical examinations of all employees believed to be physically unfit for further work to prevent them from injuring themselves or others. He must further treat and view the scene of all accidents to be able to determine their cause and to assist the safety engineer in formulating plans to prevent recurrences. He must so organize the personnel under him that prevention will be effectively handled. The safety engineer is assisted in his work by the foremen of the shops and in some instances by safety committees in each shop elected by the employees. These men or committees are generally chosen from among the older employees and from men who have considerable experience in their trade. It has been repeatedly recommended, but not as yet accomplished, that the safety organiza- tion be enlarged by the creation of two new civil service ratings. These are, a civilian safety engineer and a civilian assistant safety engineer. These men would be appointed by competitive examination and should be men who have had considerable experience in the trades with a liberal understanding of all. They would act as assistants to the naval safety officer and would be of great value to the organization, inasmuch as their duties would be permanent. A 518 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY naval officer is subject to change of duty and cannot act as permanent safety officer. In changing the safety officers at intervals a weakness is left in the organization which the civilian assistants could well fill, until such time as the new officer became familiar enough with his new duties to take hold. The organization of the medical advisor is composed of junior medical officers, dental officers, to some extent, members of the Hospital Corps, and of nurses. The duties of the hospital corpsmen are to assist the medical officer in his inspections, assist in the treatment of the injured and to prepare the necessary reports and returns in cases of accident, occupational disease, and the physical examination of employees. This, then, is briefly the organization of a safety unit in a navy yard. This unit will function as well aboard a battleship or in other places. The commanding officer of a ship is the head of the organization. He is assisted by the First Lieutenant acting as safety engineer. Division Officers act as assistants to the First Lieutenant and safety committees are elected in each division from among the crew. The medical officer is the advisor to the safety engineer and he in turn, is assisted by the dental officer and hospital corpsmen. All then that is necessary for the unit to function is that a study be made of the hazards presented aboard ship and to proceed as explained later. Hazards to health and accidents. The organization completed, a study must be made to determine the hazards existing in the particular organization to which the unit is attached. There are major hazards and minor hazards. A major hazard is represented by unguarded machinery or improperly or faulty ixasulated electrical wiring. A minor hazard is a greasy shop floor, loose articles lying around on the deck or an open, unguarded hatchway aboard ship. It must be remembered that no two industries present the same hazards. There are hazards peculiar to each trade or profession. Efforts must therefore be made by the safety organization to locate these hazards and afford protection accordingly. To indicate just what types of hazards may be encountered while working with a safety unit of a navy yard and in an effort to make the subject of hazards a little clearer to the readers the following questionnaire, prepared by the inspector of the Medical Department Activities of the West Coast is quoted in part. This questionnaire represents a very thorough picture of the major hazards with which a safety unit of a navy yard must cope, aside from the many minor ones always present in any organization. Answers to these must be made not only to the inspecting officer but they must in some form or other be answered daily if the organization is to be successful. By this is meant that problems of this nature are a daily occurrence and the safety unit must be prepared to meet them at once and not wait to formulate answers at inspection intervals. “Q. 1. What industrial processes employ lead at some stage of the work? This includes tetraethyl lead. How many workers are exposed to lead? What precautions are taken to prevent damage to workers using lead? How fre- quently are workers using lead checked to determine possible absorption of this element? “Q. 2. What industrial processes employ chromium at some stage of the work? What precautions are employed to safeguard workers from chromium poisoning? “Q. 3. What processes create a possible dust hazard? What precautions are observed to prevent damage to workers exposed to dust? Are routine examina- tions made of the chests of workers exposed to dust? Are X-rays made to de- INDUSTRIAL MEDICINE 519 termine the presence of silicosis in workers exposed to dust? Have cases of silicosis developed? “Q. 4. What industrial processes produce fumes which may be a health hazard? How are these fumes controlled? “Q. 5. What Industrial processes produce carbon monoxide in possible danger- ous concentrations? What industrial processes produce carbon dioxide in possible dangerous concentrations? Have any cases of poisoning from these sources occurred? “Q. 6. What processes employ volatile solvents during some stage of the work? Are aniline compounds used? Has damage occurred from their use? “Q. 7. Are organic wax compounds used? Has damage occurred? “Q. 8. What precautions are exercised to prevent damage from pipe covering compounds? What asbestos hazards exist? “Q. 9. What precautions are taken to prevent damage from glass wool? “Q. 10. What radio-active compounds are used on the station and what precautions are used to prevent damage from this and luminous paints?” These are but a few of the questions asked but they serve the purpose for which they were intended, i. e., to indicate just what is meant by a health hazard and ones which must be studied in Industrial Medicine. Protection. Having made a survey to determine the hazards presented in the organization to which one is attached, means of protection must be sought. This is done first by protecting against physical hazards by employing physically tit men. In the Government, the physical standards are set according to the employment and the hazards to be met with in each type of work. The U. S. Civil Service standards are as follows: 3. For employment in arduous duties. Must be physically sound and in good health, active and able bodied. Bating “A”. For some positions e. g. divers, requirements are specially rigid. Rating “A plus”. 2. For less arduous employment. Requiring sound general health but less physical strength, though for some employment special requirements exist, i. e. perfect color preception for brakemen and chauffeiirs. Rating “B”. 3. For lighter and usually sedentary employments. General good health but minor anatomical defects not interfering with efficient performance of work may be passed, i. e. a typist may be lame. Next, having employed a healthy working force it is necessary to protect their health. Proper working places must be provided and maintained. Hygienic and sanitary conditions must be kept on a high plane. All moving parts of machinery must be guarded; goggles provided for workers required to use them; helmets and masks for sand blasters; proper ventilation for the chrome workers; masks for asbestos workers; protection for workers in X-ray and radium; protective gloves, shoes, and other garments for foundry workers, and other means of protection too numerous to mention here must be available and used. Special physical examinations must be made of all sand blasters, asbestos handlers, those exposed to radium and its compounds, lead workers, those engaged in dusty or smoky trades, handlers of T. N. T. and other explosives, etc., to prevent the occurrence of the diseases associated with those trades from injuring the men. As mentioned before, all workers who are sick for any length of time and whose efficiency has fallen off because of physical reasons must be examined and either retired or reclassified. 520 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Treatment. The treatment of industrial diseases and injuries is essentially that for any others. All accidents are treated according to the severity and locality. Men are not allowed to treat themselves for even minor accidents by reason of the dangers of infection and later incapacity. The treatment of diseases of occupation is a specialty in itself and need not be considered here. Laws governing workers and accidents occurring during work. The laws governing occupational diseases and injuries are quite numerous. It is therefore essential that a hospital corpsman be familiar with only those pertaining to Government employees. These, in general, are as follows: All men injured or taken sick during the course of their employment are required to report to the dispensary for treatment. It makes no difference how trivial the accident or how minor the illness, he must still report. No first-aid boxes are allowed in any of the shops or offices. When a man reports, his injury or illness is investigated, treated, or otherwise disposed of. At the U. S. Navy Yard, Puget Sound, Wash., a form report of the case is prepared in quintuplicate, two copies of which are forwarded to the safety engineer, one copy is sent to the foreman of the shop or the supervisor of the office, one is given to the employee, and one placed in his file jacket. A separate file jacket is maintained for each employee who reports to the dispensary for treatment or for any other reason and is a permanent record which is kept during the entire time of employment. The information furnished on this report is as follows: Date; whether report is of injury or return to work; name; rating; pay number; shop; diagnosis; date and hour of injury; date and hour reported to dispensary; whether or not injury is due to employment; disposition (treated and returned to work, given time off, or transferred to naval hospital) ; name of medical officer treating case; and patient’s state- ment regarding injury. In addition to this form, a card-index form, U. S. Employees’ Compensation Commission Form CA-19, is made out in each case. This form is started when the man reports and when final disposition of the case is made it is likewise filed in the man’s jacket. When an injured employee returns to his shop or office, or when the fore- man or supervisor receives his copy of the form report, the foreman or super- visor immediately fills out U. S. E. C. C. Form CA-2, and forwards it to the injury officer, who, in turn, submits it to the dispensary for completion by the medical officer treating the case. The medical officer gets the data for this report from the forms previously described. U. S. E. C. G. Form CA-3 is forwarded at the termination of total or partial disability of an employee, or upon his death. U. S. E. C. C. Form CA-4 is a claim for disability allowance or compensation for injuries received which must be submitted by the employee within 60 days after the injury. This form must also be completed by the medical officer at- tending the case and once again the form report and U. S. E. C. C. Form CA-19 are of value. U. S. E. O. C. Form CA-8 is similar to Form CA-4 but must be submitted on the first and sixteenth of each month by the employee, during the period of his disability. When it becomes necessary for an injured employee to have hospital or other treatment not provided by a dispensary or local physician, U. S. E. C. C. Form CA-16 is made out and forwarded with the patient to the hospital or place where he is to receive such additional care. FIELD SANITATION 521 Times arise when there is doubt as to the origin of the disability, i. e., whether or not the disability is occupational. In such cases U. S. E. C. O. Form CA-17 is substituted for Form CA-16. Whenever U. S. E. C. C. Forms CA-16 and CA-17 are made out they must be accompanied by U. S. E. G, C. Form CA-20. U. S. E. C. C. Form CA-21, Discharge Report of Injury Case, is forwarded when an employee is discharged from treatment after having been incapacitated by reason of occupational injury or disease. U. S. E. C. C. Form CA-32 is a report of hernia and must be submitted in all cases in which claim is made that a hernia was caused by employment. Numerous other forms, such as public bills for payment for treatment, are used in handling these eases, but as they are accomplished by the injury officer they are not listed here. Forms showing reports of all physical examinations of employees, including the special examinations previously mentioned, are also kept. These are routine however, and are easily learned when actually engaged in this work. Special forms for W. P. A., E. R. N., and P. W. A. workers are also provided. In conclusion, it is well to state the qualifications expected of a hospital corps- man engaged in Industrial Medicine. 1. He should realize that his first duty is to the workman who is injured. 2. His personality should inspire confidence. 3. He should have a knowledge of first aid. 4. He should have a knowledge of an efficient medical record system and of statistical methods. 5. He should have a knowledge of sanitation, of working conditions, of occupational hazards and preventive measures. 6. He should possess a general knowledge of industrial relations, including employment, its methods and problems. 7. He should have a working knowledge of the workmen’s compensation laws. 8. It would be well for all hospital corpsmen to obtain and read the publication Medical Service in Industry and Workmen’s Compensation Laws, 1938, published by the American College of Surgeons as prepared by M. N. Newquist, A. B.. B. Sc., M. D., to enhance their knowledge of this subject and thereby be of more value to the medical organization of the Navy for industrial medicine. This publication contains concise, complete statements of the problems of the industrial organization and is of value to all industries. References Industrial Medicine and Surgery.—Mock, 1931. Industrial Health.—Kober and Hayhurst. U. S. Naval Medical Bulletin, January and April, 1935. Medical Service in, Industry and Workmen’s Compensation Laws, 1938. Inspection Questionnaire, West Coast Medical Activities, U. S. Navy. Section 6.—FIELD SANITATION Health is necessary in war, and cannot he replaced hy anything else.—Napoleon Introduction. The activities of a medicomilitary organization tend to concentrate toward one primary objective, “The conservation of physical efficiency for combat.” The hospital corpsmen of the Navy serve ashore, as well as afloat, and in 522 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY addition to their duties pertaining to naval warfare must be prepared to serve as members of the medical department of a naval landing party or a Marine Corps expeditionary force; and, as such, require a knowledge of field conditions. One of the prime requisites for victory is health, consequently field hygiene and sanitation is one of the most important subjects for military personnel. The functions of a military medical organization may be roughly divided into (a) prevention of disease and (6) treatment of disease and Injury. Prevention of disease is of such vast importance to military personnel that this function will be considered in this section. Preventive medicine is not an exact science nor is it possible to obtain 100 per cent efficiency. However, if by careful attention to the minor details the sanitation officer is able to increase military efficiency from 96 per cent to 98 per cent, he has not gained a mere increase of 2 per cent as it may seem, but has effected a gain of 50 per cent—that is, the noneffective rate has been reduced from 4 per cent to 2 per cent. It is this little difference which some- times may be the deciding factor between victory and defeat. Tact and a certain amount of technical ability are necessary qualifications for a successful sanitarian. Sanitation is so closely interrelated with cleanli- ness that the major portion of the duty of a sanitation officer consists in the supervision of cleanliness. The differences between field sanitation and sanitation of garrisons aro marked. 1. Field sanitation is easier to institute. For example, the devices used for the disposal of waste are of simple construction, whereas the installation of a water-carriage sewerage system requires more expert engineering knowledge, takes longer to construct, and by reason of its permanent nature is more expensive. 2. Constant vigilance is required to maintain field sanitary devices in proper sanitary condition. 3. Field sanitary appliances are a potential menace, if not properly main- tained. In established garrison life, with water-carriage waste disposal, an adequate and potable water supply, permanent housing facilities, protective screening for insect control, and similar modern developments, the duties of the sanitation officer are comparatively simple and more or less routine. In the field, the conditions are such that the field sanitary devices require constant and pains- taking personal supervision from both the line and the medical officers in order that there may not be a weak link in the chain of sanitary measures. Barracks life may give comparatively little concern, but when taking the field, vigorous sanitary measures must be instituted and maintained and, if possible, improved from day to day. The commanding officer of an organization is responsible for the health of his command and the enforcement of sanitary measures. The medical depart- ment acts in an advisory capacity. The medical officer is charged with the initiative in making necessary recommendations to the commanding officer tending to the promotion of health and prevention of disease. For instance, the medical officer should recommend the type, number, and regulation of sani tary devices, but the responsibility for the actual construction and the main- tenance of the same in a sanitary condition rests with the respective unit commanders. Likewise the collecting company of the medical battalion exer- cises supervision over sanitation, tmt the latrines, urinals, incinerators, etc., should be constructed by a detail from other units. FIELD SANITATION 523 Victory, success in a military endeavor, is intimately interrelated and dependent upon personnel losses; in fact, the wastage from diseases frequently assumes such magnitude as to cause military campaigns to terminate in disaster. When a million men are placed in the field and decimation from disease is prevented, it is defying one of the biological principles that tends to prevent over-crowding of a species. The methods available to combat these fundamental biological principles are not complicated and may be classified and will be dis- cussed as follows: 1. Proper food. 2. Potable water supply. 3. Hygiene of the march. 4. Conservancy—waste disposal. 5. Insect control—fly, mosquito, louse, etc. In war the supply of food is most important. The men attached to an organ- ization on field duty are likely to be entirely dependent upon the military ration. Hence, it is important that the field ration be well balanced in fats, proteins, and carbohydrates and it must have the required vitamin content. An extended discussion of the component parts of a well-balanced ration would be a departure from the subject of this section and, as such data may be found in chapter VIII of this hook, only certain aspects of a military ration which are related to field conditions will be considered. Caloric value of the military ration.—It has been found that a ration con- sisting of 3,700 calories is insufficient for troops in the front line. It has been experimentally proved that troops on a test march can maintain weight on a ration of 4,100 calories. If troops must entrench after a day’s hike, a total of 5,000 to 6,000 calories per day is required. It is often impractical for a soldier to assimilate such a large number of calories per day, and consequently, in time of war soldiers are allowed a greater amount of food (often at the expense of the civilian population) so that they may have a reserve supply of fat in the body to enable them to temporarily withstand the unusual expenditure of foot-pounds of energy. It is stated that 20 pounds of reserve fat in a man’s body will supply 3,000 additional calories per day for a period of 30 days. The following is the caloric value of the United States Army ration; FOOD Calories 1. Reserve (haversack ration) 2,825 2. Mobile - 3,500 3. Normal 4,125 4. Special 4,850 The heat of hot drinks and hot food supply additional calories, 1 pint of hot tea adding 50 calories of direct heat to the body. Hence the stimulating effect of hot tea, coffee, soup, and broth after a long march. A soldier at hard work requires 24 ounces of food, daily, exclusive of water, made up as follows: Ounces Proteins 4 Carbohydrates 17 Fats : 3 154294°— 39 34 524 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In terms of articles of food, the above is represented by the following field ration : Beef ounces 11 Sugar ounces— 2 Cheese do 3 Jam do 2 Bread do 16 Sago do 4 Potatoes do 10 Milk pint % The nitrogenous foods (proteins) serve for the building and repairing of tissues, and also serve for the maintenance of heat and energy. The carbohydrates and fats yield heat and energy. The mineral salts are essen- tial to life and health, and for the formation of the skeleton and tissues. Water is as essential a food as the foregoing, and serves for the solution and convey- ance of food to the various parts of the body, and also for the removal of the waste products formed in the body, viz., the solid and liquid excreta. Water alone, by its evaporation from the skin, assists in stabilizing the temperature of the body. A part of the water required by everyone is contained in the solid food taken, of which it forms a very large proportion; meat, for instance, contains about 75 per cent water, some vegetables as much as 90 per cent, and bread about 38 per cent. The amount and the particular kind of foodstuffs required by an individual will vary with his age, his build, his work, and the climate in which he works. In cold climates a man will require more of the heat-producing foods, espe- cially fats, and in a hot climate he needs less of the nitrogen-containing foods and fats, and more of the vegetable foodstuffs. The greater amount of muscular energy required, the greater will be the amount of food necessary to supply this energy. The energy value of food is generally expressed in large or kilo-calories, a large calorie being the energy, in the form of heat, required to raise the temperature of 1 kilogram of distilled water from zero to 1° C. It has been found by experiment that 1 Gm. of protein or carbohydrate is capable of yielding, by its oxidation in the body, 4.1 calories, and 1 Gm. of fat, 9.3 calories. Daily menu.—It is advisable to prepare the daily menu at least 24 hours in advance. It should provide food of satisfactory quantity, quality, and variety. There is often a tendency for cooks to prepare an excess of stews, which may cause dissatisfaction among the men. When on the march or otherwise heavily worked, the men will have a craving for sweets; a liberal amount of jam should be provided to satisfy this craving. The presence of much refuse food in the garbage can is a good indication that the men are not receiving the proper kind of food, that it is not palatably cooked or served, or the qiiantity is excessive. The field ration should contain tomatoes and lemon or orange juice whenever practical. Potatoes should be cooked and eaten unpeeled, thus supplying additional vitamins. Fruit and vegetables which are to be eaten raw and unpeeled, should have the exterior surface sterilized by temporary immersion in boiling water whenever there is suspicion of soil contamination being present. Every effort must be made to vary the field diet to the greatest possible extent, changing the food substances as well as the manner of cooking. The guard at night should have coffee and bread before going on duty, and this should apply to relief parties. FIELD SANITATION 525 Field kitchens.—The use of rolling kitchens on the march has superseded the old method by which each man cooked his own food. One rolling kitchen supplies food for 200 to 250 men. The field kitchen should be located on the opposite side of the camp from the latrines and urinals. Somie means should be used to protect the food from dust and sand. If circumstances permit, the kitchen should be screened; if not, other precautions should be taken to protect food from flies and other insects. Burlap sacking may be used for screening when more suitable material is not available. There should be on hand at all times a sufficient supply of pure water and material for cleaning purposes, such as soap, soda, and soap powder. Scouring material, boiling water, and dishcloths should be available. If the kitchen has a dirt floor it may be oiled wflth used motor oil to control dust. The cooks and other attendants working in the kitchen and handling food should be instructed and trained in personal hygiene. Food handlers should be required to wash their hands thoroughly after each trip to the latrine. Rigid supervision is necessary to prevent the cooks from becoming lax in personal cleanliness, especially in keeping the hands and finger nails clean. Physical examination of all food handlers should be made at regular inter- vals, and, if the laboratory facilities permit, an effort should be made to detect and eliminate any disease carriers among them. Frequent venereal inspections also should be made. Liquid and solid refuse should be disposed of as soon as possible. The outside of all garbage cans should be kept clean, and covered at all times. The object of cooking processes is: (а) To make food more digestible and appetizing; and (б) To destroy germs and parasites. Mess halls.—The mess halls should be located near the kitchen and all possible provisions to protect the food in the mess halls from flies, dust, and sand, using wire screening if available, must be taken. Clothes and toilet articles must not be stored in kitchens or mess halls. The mess tables should be cleaned and sunned at regular intervals and care must be taken to see that food particles do not collect in the cracks of the tables. One of the best methods to prevent the collection of food particles in the cracks of the tables is to construct the tables with a removable center board which may be lifted off, and thus permit the cleaning of the cracks between the boards. Another method is to construct the tables with a 2-inch space between the boards. Washing mess gear in the field.—After meals all mess gear should be sterilized in boiling water. In a semipermanent camp the mess gear may be placed in wire racks and washed by immersion for 5 minutes in water that is kept boiling. On the march and under conditions where the mess kits from the haversack are in use, the following method of washing the individual mess gear is em- ployed : Immediately after the men have finished eating they should form a line and pass a garbage can or pit where the refuse liquid and solid foods are disposed of. After disposing of this refuse food each man inserts his mess gear succes- sively in three cans. These cans are placed over a trench in which a fire is burning. The first and second cans contain boiling soapy water, while the third can contains boiling clear water. A few moments insertion in each of these cans is usually sufficient to cleanse and partially sterilize the utensils. After 526 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY insertion in the third can, the mess gear dries by its own heat almost im- mediately and no wiping is necessary. Care should be taken to see that the water in each can is kept at a boiling point, as lukewarm dishwater is a potent factor in the dissemination of saliva-borne diseases. Protection, storage, and inspection of food supplies.—Surplus and reserve food supplies should be protected from insects such as flies and roaches, from dust and dirt, and from rats and mice. Perishable foods should be stored at a tem- perature that will inhibit the growth of molds and bacteria. For camps of less than 1 week’s duration, storage devices for preservation of food are not necessary. 1. In temporary camps food may be stored in watertight containers and im- mersed in springs or streams, care being taken to prevent water contamination. Food may be buried below the surface of the ground where the temperature is lower, lining a pit with burlap, and placing boards on the bottom. In addition, food containers suspended from trees or tripods and underground ice boxes provide satisfactory means of protecting and storing food. A suspended food container consists of a screened box that permits free cir- culation of air but prevents contamination by insects. The cooling effect is increased by wrapping the box in burlap which is kept damp. Fresh meat, bot- tled milk, and vegetables may be temporarily stored in such a container. It should not be used where the air contains any considerable amount of dust. 2. In semipermanent camps fresh or cured meats, milk, and vegetables should be kept in an underground storage room constructed similar to an old- fashioned root cellar. The floor consists of well-tamped earth, or boards may be used. The walls should be boarded. Ventilation is secured by windows at the ends or an outlet through the roof. Vegetables should be kept in vege- table bins, constructed of spaced slats to permit the circulation of air. The bottom should slope sufficiently to permit the older vegetables to be used first. Canned goods should be kept in the storeroom adjacent to the kitchens. Bread boxes which permit aeration of the contents should be used. The quality of meat can be recognized by the appearance, odor, and texture. Good meat is firm to touch, moist but not wet, and is red in color for beef, pinkish brown for veal, dark pink for mutton, and light pink for lamb and pork. Good meat has a fresh, agreeable odor. The fat should contain no watery juices or jelly, and should be firm and white. The fat interposed between the muscle fibers gives the meat a mottled appearance. In the field, inspection of the freshly-killed carcass may be necessary. The most likely place to look for signs of disease is the chest cavity, and to a lesser extent the abdominal cavity; adhesions of the lining membrane indicate inflammation, probably tuberculous. When decomposition of meat is suspected trim off the tainted parts of the quarter of beef and sink a probe into the shoulder or hip joint. The odor of the probe will determine whether decomposition has set in. A whole quarter of beef should not be condemned because part of it has begun to decompose, as it is often possible to trim off the tainted portion and serve the remaining wholesome portion. The Eber test (ammonia test) is used to detect decomposition. Place 2 cc of reagent (1 part ether, 1 part concentrated hydrochloric acid, and 3 parts absolute alcohol) into a test tube and shake. A small piece of meat to be tested is lowered to within one-fourth inch of the surface of the reagent. If ammonia is present white ammonia chloride fumes will appear around the specimen. FIELD SANITATION 527 Meat may be hung in cold storage but it should not be stacked in the refrig- erator until it has been thoroughly chilled, preferably frozen thoroughly. When warm meat is stacked in the refrigerator decomposition develops in the center part of the stack before it can be frozen. The hind quarters and fore quarters should be stacked to permit issue alternately. In the held a percentage of the rations is issued in tin containers, which, due to improper preparation, exposure to excessive heat, and lack of care in handling, frequently undergo decomposition and are especially dangerous to health if their use is permitted. Therefore a careful inspection of all canned goods should be required. The terms “springers” and “swells” are applied to bulged, blown, or swelled cans. These cans, when pressure is applied at the ends give a crackling sound. “Springers” are caused by overloading the can, and though not desirable, the contents are fit for use. “Swells” are caused by the formation of gas, due to decomposition and may be differentiated from “springers” by a splashing sound when the can is shaken, and a hollow note when the can is gently tapped. These should always be condemned. Occasionally the inside of a can may present a blackened appearance—so- called “can burn.” This condition is not due to putrefaction, but is caused by the precipitation of stannous (tin) sulfide in an acid medium. Formerly a can with two solder holes was indicative of a “swell” which had been punctured to let out the gas and then resoldered, but now many manu- facturing firms use two solder holes in sealing their cans. It is well to reject cans with three solder holes. Vitamins.—Vitamins are accessory food factors that occur in minute amounts in natural foods and are in varying degree essential for normal body growth and maintenance. They are discussed in the chapter on Diets and Messing for the Sick. Conservation of food vitamins.—Several simple but important facts must be remembered in providing troops with an adequate intake of vitamins. Personnel charged with preparing food for consumption should be familiar with these facts and conserve food vitamins. The vitamin content of foodstuffs decreases with age and exposure to heat, light, oxygen, and alkali. Since vitamins are water or fat soluble, the water, or fatty liquids in which foods are preserved or cooked contain vitamins and other beneficial extractives which should be incorporated in the ration, if possible, rather than discarded as waste products. Prolonged cooking, such as is apt to occur with field kitchens, tends to destroy the vitamin content of the ration. The vegetables for stew should be cooked separately and not longer than 30 minutes; then they should be added to the meat, which requires about 2 hours of cooking. Avoid the use of alkali, e. g., sodium bicarbonate, when cooking green vegetables as it tends to destroy the vitamins. The vitamin-containing foods of an exclusive military ration should weigh at least 30 per cent of the total. WATER Responsibility for water supply.—The quartermaster is responsible for the procurement of water rights and for the delivery of water to the camp site. The medical officer is responsible, in an advisory capacity, for the quantity and the quality of the water at the source as well as at the ultimate point of consumption. The unit commander is responsible for the proper distribution of the water within the organization. Water consumption.—Water constitutes 60 per cent of the body weight, or the equivalent of 10 gallons, which equals 100 pounds approximately in the average 528 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY man’s body. The loss of 1 gallon of this water has serious consequences; if IV2 gallons are lost, the result is fatal. (The volumetric measures used here are Imperial). The quality and quantity of the water supply is a vital factor during field operations. In a war of movement the supply of water is very apt to he inadequate, which may mean that the consumption of water will have to be restricted to a minimum. The minimum allowance of water for the needs of men and animals varies according to the amount of daily labor performed and also the conditions of the weather. The following may be taken as an absolute minimum: Each man, 1 gallon per day, to be used as follows—IV2 quarts for drinking, 2y2 quarts for cooking and drinking with meals. In combat, a soldier can maintain physical efficiency for 2 days only on one-half gallon of drinking water each day. This is the minimum for soldiers on the march and in bivouac, and provides no allowance for the washing of person or clothing. In camps of more than 1-night duration the following minimum allowance should be furnished: Gallons In barracks 20 In camps 5-10 Drinking and cooking only 2 The daily requirements for animals are: Horse 10 Mule or donkey 6 Source of water.—The sources of water are divided into (a) surface waters, such as lakes, ponds, rivers, streams, etc.; (&) ground (underground) waters, which include wells, springs, etc,; all these vary in degree as to purity and pot- ability. Rain water is usually the most satisfactory of all natural waters. Large bodies of water are more likely to contain pure water than small ones, because of the greater dilution of the contaminating material. Water which is obtained from the center of a large lake is very apt to be pure, especially where the sun shines upon it. One should always be suspicious of all surface waters as the appearance of water is no index as to its purity. Water should be considered contaminated until tests prove it potable. Also, water found potable may become contam- inated subsequent to test. Consequently, water used for drinking and cooking purposes should be guarded and tested frequently for contamination. Wells are of two Varieties, “deep” and “shallow.” Water taken from shallow wells is always suspicious, while water taken from deep wells and deep springs is usually fit for human consumption. 1. If water from a running stream is used, it should be taken from a point where there is considerable depth, and where the current is strong, always upstream, or in other words, above the campsite. Upon arrival in camp, a guard should be posted over the water supply and the stream should be in- spected and marked for use. Beginning upstream the water should be assigned for use as follows: (a) Drinking and cooking water; (ft) Water for animals; (c) Water for bathing; and (d) Water for laundry purposes. To compute the volume of water of a flowing stream the following may be used as a guide: Sectional area in square feet, multiplied hy 0.8 velocity in feet per minute, multiplied by 748, equals the flow in gallon# per minute. 2. Rain water, though not very palatable, is the safest 'and purest of waters. In warm countries it may be necessary to use it for drinking purposes but it FIELD SANITATION 529 must be properly collected and stored. Rain water is easily collected from the roofs of houses or other prepared surfaces. These surfaces must be kept free from pollution, such as excrement of birds, dust, decayed leaves, etc. The first washing of the rain should never be used as it will probably contain some pol- lution from the roof. In storing the rain water, the containers should be well- screened and ventilated, and frequently cleaned to prevent pollution. One inch of rainfall produces 22,500 gallons of water per acre. The number of gallons of rain water expected to be recovered from a roof may be determined by the following formula; Area of roof in square feet, multiplied by one-half the rainfall in inches, equals the number of gallons. 3. Well water usually comes from two sources. The greater portion filters in from the deeper strata of the soil and may be considered as free from con- tamination, However, wells are rarely properly encased near the surface and properly covered as protection against surface water drainage and other pollution. Therefore all wells should be regarded as contaminated and should be cleaned and disinfected prior to use by employing the following measures: (а) Remove all refuse from well. (б) Pour into well about one-half barrel of a solution of freshly burned lime (or a 1 per cent solution of chlorinated lime can be used). (c) Scrub sides of well with this solution. id) Wait 2 hours, pump well dry, and repeat above procedure. (e) Wait 24 hours, pump out well, allow to refill. if) Continue to pump out until all taste of lime has disappeared. ig) Sterilize water in well by adding a solution of chlorinated lime— 80 grains to every 100 gallons of water in well. To compute the number of gallons in well use formula: The square of diameter of well in feet multiplied by 0.7854, multiplied by depth of well in feet multiplied by 635 equals gallons in well. Transportation and storage.—Water carts employed in the transportation of water should be subjected to the following sanitary measures: (a) The tank of water cart should be scrubbed out every 4 days with a 1 per cent solution of chlorinated lime. (5) Water carts should never be devoted to other purposes than to provide drinking water for men. (c) A half teaspoonful of chlorinated lime—30 grains—well dissolved as a paste, added to 100 gallons of water will produce approxi- mately 1 part per million of free chlorine, and is sufficient to sterilize this quantity of water. The best storage containers are those made of concrete, slate, or galvanized iron. Wooden containers will, after a time, give the water a very disagree- able taste. Water receptacles should be well covered. As the ground in close proximity to a water faucet is likely to be wetted, it is best to build a sand or gravel pit, 2 feet square and 1 foot deep, to absorb the waste water. The receptacles should be cleaned daily with boiling water, or rinsed with a solution of potassium permanganate (one-third teaspoonful to 1 gallon of water). A solution of chloride of lime is also very good for this purpose, in proportion of 1 to 1,000. These solutions are harmless and more certain in their action than boiling water used alone. Canteens, when not in use, should be emptied, dried, and cleaned with one of the above solutions. Weak tea has been highly recommended for drinking purposes in canteens; it should be boiling hot when poured in, thus insuring the sterility of the canteen as well as of the contents. 530 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY Common drinking cups should not be used; however, if individual drinking cups cannot be supplied, lip drinking should be practiced. Should conditions arise which make it absolutely necessary to use common drinking cups, a certain degree of safety can be insured by keeping the cup immersed in a 1 per cent solution of formaldehyde. Purification of temporary water supplies. General.—The water supply for mov- ing troops, for temporary camps and installations, or for troops in the theater of operations frequently must be purified under conditions which do not permit the installation of permanent or semipermanent water purification works. The agencies employed generally for this purpose are: 1. Chemical; 2. Heat; 8. Filtration. Chemical purification.—Chlorination is extensively practiced today. Hypo- chlorite of calcium, commonly called bleaching powder, is the substance used, and is issued by the quartermaster in small glass tubes. The ordinary calcium hypochlorite (Calx chlorinata) or bleaching powder, contains 33% per cent of available chlorine when freshly prepared, but is an unstable substance, so that the supply received xhay contain but little chlorine. There are hypochlorites available however, and now recommended for use, which contain well above 60 per cent available chlorine, are very stable and easily miscible. Bleaching powder tends to form small, hard lumps when placed in water. In preparing a hypochlorite solution just sufficient water should be added to the powder to permit the easy formation of a smooth, thin paste, which is then diluted as required and placed in the chlorinator. Twenty-five pounds of ordinary bleaching powder added to 1,000,000 gallons of water give one part per million of chlorine. If 4,000 gallons of water are to be chlorinated one-tenth pound of hypochlorite is sufficient. A drip chlorinator may be used in a small stream, the size of the containers and the strength of the solution being determined by the rate of flow of the stream, however, the drip chlorin- ator is not recommended. In case water is so turbid as to make it unsatis- factory for use, it may be clarified by allowing it to stand for some time in a reservoir and clarification may be hastened by the addition of chemicals. Alum, lime, and soda ash are used for this purpose. Chlorinating water for small detachments.—Small detachments separated from the main body of troops and its pure water supply may be provided with safe water by chlorination of canteen water. The contents of one tube of calcium hypochlorite are dissolved in 1 quart of water and preserved in a glass bottle. A metal container is not used as the concentrated calcium hypochlorite has a chemical action on the metal. One teaspoonful of this solution added to 1 canteen of water and allowed to stand for 30 minutes renders the water safe for drinking. If the tubes are not available, then dissolve 1 teaspoonfifi of chlorinated lime taken from a freshly opened container, in 1 quart of water and label this “stock solution.” This solution deteriorates very rapidly and fresh solution should be prepared every fourth day. One teaspoonful of this stock solution added to each gallon of water and allowed to settle for 30 minutes will insure the destruction of most bacteria. Sterilising water hy iodinisation.—Two and one-half teaspoonfuls (10 cc) of 7 per cent tincture of iodine added to a sterilizing bag of water will purify it in 30 minutes. Two drops of the tincture added to one canteen of water and allowed to stand for 30 minutes will render it pure. There are two objections to this method of sterilization: 1. There is no reliable method for titrating the iodine in a test for sufficiency of the amount added; and 531 FIELD SANITATION 2. This method is more expensive than the hypochlorite method. (The excess of iodine may be neutralized by adding 1 gram of sodium thiosulfate.) Water sterilizing lag.—The water sterilizing bag, often called the Lyster bag, is made of specially woven, waterproof canvas, weighs about 7 pounds, and can be folded into a compact package. It measures 20 inches in diameter and 28 inches in length, and holds about 36 gallons. (Fig. 185.) Its sole use is as a stationary receptacle for water while being sterilized and distribution of same after sterilization, without dipping. This is accomplished by faucets which are arranged around the bottom of the bag. The Lyster bag is part of the Marine Corps field equipment and is issued on the basis of 1 bag for each 100 men or fraction thereof. In use, this bag is suspended from a tripod and filled with water. To each bag of water (36 gallons) there is added the contents of 1 ampule of cal- cium hypochlorite. The calcium hypo- chlorite is issued in sealed glass tubes, one tube sufficing for one bag of water. The water is then allowed to stand for at least 30 minutes before using, as the sterilizing process is one of oxidation, and is not complete in less time. In water that contains much suspended matter, or is very cloudy, the sterilizing action is not very satisfactory so that it is necessary to clarify the water be- fore chlorination which may be accom- plished by means of a small filter cloth provided with the bag. 1. Arrange bag on tripod. Strain water and fill bag to within about 4 inches of the top. 2. Procure a clean stick, or cut a limb from a tree for use in stirring of water. Place this in water and leave there during sterilization. 3. Break one of the glass ampules of calcium hypochlorite and shake the powder into a cup. Mix with water until a fine paste results, and then- stir with a spoon, adding more water until the paste is entirely dissolved. 4. Add the hypochlorite solution to the contents of the bag and mix thor- oughly with the stick provided for that purpose. Draw 3 cupfuls through each of the faucets (to clean and sterilize) and pour back into the bag. 5. Draw off 1 cup of water and add to it the contents of 1 ampule of ortho- tolidine, stirring with a clean, dry spoon. As the water is stirred it turns yellow, the degree depending on the amount of hypochlorite present. An orange or orange red color indicates a sufficient amount for sterilization. A canary yellow color indicates an insufficient amount and hypochlorite should be added to the bag 1 tube at a time until the right color is obtained. The water is then allowed to stand for 30 minutes and guarded to prevent use during this period. Figure 135.—Water ba 532 HANDBOOK OF THE HOSPITAL CORPS, XL S. NAVY 6. Excess chlorine gives the water an unpleasant taste. This can be dis- pelled by neutralization with sodium thiosulfate. Sodium thiosulfate is provided in glass ampules. The contents of 1 ampule should be added to a cup of water, stirred until dissolved, and after sterilization of the contents of the bag is complete, should be poured into it. 7. The faucets should then be rewashed for the last time, running at least 5 cups of water through each faucet and returning the water to the bag. This treatment renders the water perfectly safe, even though it was previously heavily contaminated. 8. Unless precautions are taken men will drink directly from the faucets. They should be required to use their individual mess-kit cups. 9. The bag cover may be supported in the center by means of a wire to the apex of the tripod support. This gives a pitched-roof effect, allows rain water to run off the top and prevents sagging of the top and contamination of the contents. Mobile water purification unit.—The United States Marine Corps has pro- cured two highly efficient mobile purification units, and has placed one on each coast. Essentially the unit consists of the following: 1. Gasoline engine-driven centrifugal pump. 2. Pressure filter. 3. Chlorinator. 4. Soda-ash feeding device. 5. Suction hose and discharge hose. These are mounted on a circle-steer highway trailer. The pump has the following capacities: 1. Twenty-five gallons per minute against a 10-foot delivery head through filter. 2. When filtration equipment is bypassed—in case the raw water is suf- ficiently clear—the pumping equipment and solution feed chlorinator will deliver 50 gallons per minute of sterilized water against a 50 foot head. 3. When filtration and purification equipment is bypassed, and the unit used as a pumping device, then 100 gallons of water per minute can be delivered against a 75-foot head. Thus the mobile unit may be operated as: 1. A simple pumping unit; 2. A pumping and chlorinating unit; or 3. A pumping and filter unit, with or with- out chlorinator. It is rather spectacular to watch the operation of one of these units with the suction hose placed in a muddy contaminated pond of water deliver a clear purified stream of potable water, at the rate of a barrelful each minute, at the discharge hose. Boiling.—Boiling is a simple and effective method of water sterilization and may be used in the presence of an epidemic of intestinal disease, such as dysentery or cholera, and when materials are lacking for sterilization by other methods. However, boiling all drinking water entails a considerable amount of fuel and time. For 250 men nearly three barrels of drinking water are required each day and it would be a heavy task upon the rolling kitchen if the boiling is to be done there. Boiled water has a flat taste unless it is aerated after cooling. Its taste may be improved by the addition of tea or coffee. FIELD SANITATION 533 Each man can boil water in his canteen, by placing the canteen full of water in a fire, or upon hot coals until the water boils, after which it is removed and allowed to cool. Troops can, after a day’s march, prepare their canteens full of boiled water for use on the next day. Field filters.—The barrel filter consists of a small barrel inserted into one of larger dimensions and separated from the bottom of the larger barrel by about 3 inches of fine sand. The smaller barrel having a perforated bottom, is placed upon the sand in the larger barrel; then more sand is placed around the small barrel to the height of about 6 inches. A layer of charcoal and a layer of gravel may be placed above the sand. The barrel filter may be sunk into a lake or spring; water may also be filtered by pouring it into the larger barrel. In connection with drinking water, special attention should be given the following: 1. Regard all water in the field as contaminated unless proved otherwise. 2. Do not let the men fill their canteens from any unauthorized source. 3. Place a guard at the source of the water supply to prevent its pollution. 4. Water discipline on the march should |?e rigidly enforced. 5. Remember that not only the quality of the water supply but also its quantity should be supervised by the medical officer. 6. The amount of water lost by evaporation, and otherwise, by a man marching for 1 hour, or 3 miles, is nearly 1 pint. 7. The results obtained by modern military organizations demonstrate that water-borne diseases are preventable. 8. The prevalence of a water-borne disease in a camp indicates a weak link in the chain of sanitary measures. “Field Conservancy” is a technical term employed to designate the disposal of waste products in the field. The disposal of waste products is one of the most important field sanitary measures, and the importance of proper waste disposal was known to the ancients. Burial was the earliest means of disposal and is instinctive in many of the lower animals. Field sanitary measures of modern military preventive medicine have reached a stage in development in which it is now possible to assemble a million men in the field and prevent decimation by epidemics. Waste products may be divided as follows: 1. Refuse: (a) Garbage. (ft) Rubbish (boxes, paper, etc.) 2. Excreta: (а) Night soil (urine and faeces). (б) Manure (stable litter). Or they may be classified as follows: 1. Solids: (a) Human faeces. (&) Kitchen garbage. (c) General camp rubbish. id) Stable refuse. FIELD CONSERVANCY 534 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 2. Liquids: (a) Urine. (ft) Kitchen sullage. (c) Ablution water. The proper disposal of waste constitutes one of the most important functions of the field sanitarian. In the disposal of waste the following objectives are involved: 1. Prevention of insect breeding.—To change the nature or location of waste matter so that fly breeding will be prevented, and also the breeding of other disease-carrying insects. 2. Destruction of microorganisms.—To destroy or otherwise eliminate the presence of organisms which may cause disease. 3. Removal of a nuisance.—Waste matter and filth are almost synonymous terms; and, as such, the accumulation of waste creates a condition which is offensive to the senses of sight and smell. The methods for ultimate disposal of waste products can be grouped into two main procedures, namely : 1. Burying: (а) Shallow—Temporary camps. (б) Deep—Semipermanent camps. 2. Burning—Permanent camps. In camps not of a permanent nature and with moving troops, burial is a more convenient and rapid means of waste disposal and is universally practiced in modern armies. Incineration has the advantage of complete destruction of all waste and is the better method, from a sanitary standpoint, for permanent camps. Collection and disposal of refuse.—Metal garbage cans, if available, should be placed at intervals in the company streets for the disposal of waste paper, burnt matches, cigarette stumps, fruit peelings, etc. The use of receptacles of this sort accomplishes primary cleanliness of the camp and inculcates the habit of cleanliness in the men. If metal receptacles are not available, wooden or cardboard boxes may be employed. Garbage cans should be well covered and placed on raised platforms at least 2 feet from the ground. The soil beneath these platforms is easily contaminated by the overflow of drippings, and requires careful supervision to prevent pollu- tion and fly breeding. The surface beneath garbage cans should be scraped daily and shoveled into the garbage cans. Fresh dry earth should be spread over the scraped area. The promiscuous use of lime to cover filth is not recommended. Shallow burial.—The surface of the earth usually consists of bacterial soil varying from a few inches to a few feet in depth. The top layer of the earth’s surface is inhabited by millions of friendly germs—the germs of decomposi- tion—which break up organic matter into various gases and water, and so rid the earth of the debris which would accumulate on the surface. (See p. 436.) It is part of the scheme of Nature that it must be so, for if constant breaking up of organic matters were not going on, the surface of the earth would become choked and one would find himself up to the middle in leaves, which fall and accumulate. The surface of the earth is always assisting in this destruction of organic matter. This layer of germ-charged earth is known as the live humus or living filter, because the germs not only destroy organic matter, but they prevent the passage of filth into the soil. The live humus varies in depth according to the nature of the soil, and is deepest where the soil is very light and where air can FIELD SANITATION 535 percolate through the surface, in which case it may reach to a depth of 2 or 3 feet. Usually, the depth of this humus-bearing soil is 1 to iy2 feet. Below the level of the live humus the earth is sterile or free from germs, and, if buried deep, organic matter such as excreta receives no assistance from the earth in the matter of decomposition. The live humus varies in its intensity from time to time, for if the germs are well fed they increase and multiply, whereas if they are starved they perish. Germs require food, moisture, and warmth for their growth, and if well sup- plied with these they will multiply in proportion to the amount of food they obtain. Thus the live humus varies in intensity according to the time of year, for in a very dry summer, when the surface of the earth becomes bone-dry, decomposition may be absolutely arrested, and a body may become mummified or sun dried if it is covered with sand to keep off flies. (Moss-Blundell.) The Allahabad system.—Nitrification of excrement in the soil is the sole aim of sanitary science, and the more intimately the excrement is mixed with the dry earth the quicker will nitrification occur. (See p. 437.) The germs which cause nitrification are in the upper few inches of the soil and this fact is taken advantage of in the disposal of excreta by the so-called Allahabad system, as used in India. An area 16 feet long and 5 feet wide is excavated to the depth of 3 inches. The excavated soil is placed at one end. The denuded area is then loosened to a depth of nine inches. The area is sufficient to dispose of 60 gallons of night soil, when dumped in the center. The liquid waste is absorbed by the loosened soil. The solid matter is spread over the area, and then covered with the 3 inches of soil previously removed. This is tamped down. In a few weeks, depending on the temperature, the solid matter is completely decomposed and all pathogenic germs are destroyed. The Allahabad method is useful in permanent campsites—using the bucket system—where fuel is limited for incineration, but under the usual field conditions this method is of more academic interest than practical value. Shallow latrines.—On the march: A marching column is supposed to rest for 10 minutes every hour on the march, and during the rest period the medical officer should see that some place is provided for the men to relieve themselves. As soon as the column halts, a sanitary detail from the company should im- mediately proceed to improvise latrines. A few narrow trenches about 8 inches deep and 1 foot wide will suffice, and can be hastily constructed with a sharp stick, spade, or bayonet. The sanitary detail should remain behind to fill in the latrines with earth when the march is again resumed. In temporary camps: Camps which are to be occupied for 15 days or less should be provided with “straddle trench” latrines with dimensions as follows: 1 foot wide, 2 feet or less deep, 3 feet long. The straddle trenches are also called the “One-two-three” latrines because of their dimensions. These shallow trenches are more effective in disintegrating solid waste than the deep trenches, as the germs of nitrification are found only in the upper few inches of the soil. All excretions and disease-producing organisms, even the toilet paper, disappear in these shallow trenches in 4 to 5 weeks, as one investigator reports. Straddle-trench latrines should be constructed parallel to each other and should be 3 feet apart; the loose earth should be heaped close to one end of the trench. A shovel, spade, tin, or other similar article should be on hand, and each man should he required to cover his dejecta with loose earth after deflation. In addition straddle-trench latrines may he sprayed with crude 011 or covered with quicklime, and then covered with a layer of earth daily. 536 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Often it is necessary to establish a guard in the sanitary area to prevent this weak link in the chain of sanitation. The straddle trench latrine may be designated the open shallow latrine. Sixteen feet of trench should be provided for each 100 men. Deep latrines.—The open, deep latrines, similar to those used during the Spanish-American War, and which created such insanitary conditions and contributed to the spread of typhoid fever, will be omitted from discussion, for quite obvious reasons. In semipermanent and permanent camps deep, covered latrines are recom- mended. These latrines require more time and labor to construct than the shallow- trench latrines, but have the advantage that they are easier to make fly proof. Figure 136.—Modification of standard U. S. Army latrine box. The dimensions for deep latrines vary considerably, but the following may be taken as a standard: 2 feet wide, 6 feet deep, 7% feet long. In loose soil it may be necessary to revet or face the latrine pit. The Army latrine box is an excellent type of cover for deep latrines. The exact specifications for building this box will be found in figure 136. The box consists essentially of an inverted open box built to a convenient height above the ground, containing pear shaped holes in the top, with lids covering these holes. The lids are made to open not over 85°, which will cause them to close automatically. A space of one-fourth inch should he left at the seat hinge to allow for the swelling of the wood. These deep latrines are usually intended for use over a long period of time. Most of the odors of latrines are due to ammoniacal and other decomposition of urine and the separator system is sometimes used to separate the urine from the fseces. A urinal soakage pit is built close by, and by means of a tin gutter, built in front of and under the seat, the urine accompanying defsecation is drained into the soakage pit. A urinal trough connected to a soakage pit should be constructed within the latrine enclosure. The latrine is improved by erecting it on a mound a foot high composed of earth removed from pit. This mounding of earth prevents surface drainage into the pit causing the contents to overflow. Latrines should be abandoned FIELD SANITATION 537 when filled to within 1 foot of normal surface level, and when abandoned they should be liberally sprayed with crude oil or covered with quicklime and. mounded with earth. When dug in wet soil a foot or two of water often appears in the bottom of the pit. Such water aids in absorption of the contents into the surrounding soil and many such latrines exhibit septic action. Two boxes should be provided for each 10 men. Site and number of latrines.—Latrines should: (a) Be constructed at least 100 feet from the camp, although deep closed latrines may be constructed at a distance of 50 feet; (ft) Be constructed on the side of the camp opposite to the galley and kitchen; (c) If practicable, be located so as to drain away from the water supply; (d) Be placed at a safe distance from ditches and gulleys to avoid the overflow which might be caused by a heavy rainfall; and (e) Be located to leeward of the camp, if practicable. Separate latrines should be constructed for officers and men. The seating capacity of the latrine area, as given by various authorities, ranges from 5 to 15 per cent of the command, depending upon the conditions. For commands on the march, stopping for only 1 night in camp and breaking camp shortly after breakfast, a latrine frontage of 1 yard for every 10 men is not an excessive allowance. It is not always practicable to construct this number, and under such circumstances the medical officer should be satisfied with a 6- to 8-per cent frontage, using the latter figure for commands under 500. In a semipermanent camp estimate 1 seat for every 15 men. The advantage of straddle-trenches is that the sides are not subject to contamination by urine. A trench lasts 1 to 2 days. For straddle-trenches the frontages required in yards is 6 times the comple- ment in hundreds—that is, 200 men will need 12 yards of latrine frontage. The depth in yards is two-thirds the number of days stay in that camp. Care of latrines.—When' deep latrines are filled to within 1 foot of the surface with excreta, they should be filled in with earth and abandoned. The tilled-in latrines should be covered with a mound of earth and labeled with an “L” if practicable. This marking of the abandoned latrines serves to inform future occupants of their site. The inside of deep-trench latrines should be darkened by the use of tar paper, lampblack, or other suitable material. The use of a dark substance tends to prevent the entrance of ova-depositing flies. This depends upon the principle that flies usually avoid dark places. The box cover may be removed occasionally and the inside burned out with kerosene or crude oil. In order to prevent the egress of any fly larvae which may develop in the depth of the latrine and burrow through the ground around the mouth of the pit, an area of about 4 feet around the pit should be covered wdth crude oil, or a 5-per cent solution of cresol. A better method is to cover the area with burlap sacking soaked with crude oil. It is very desirable that some provision be made for the men, especially cooks and other food handlers, to wash their hands after using the latrines. Sufficient toilet paper should always be available. In order to prevent the possible flooding of latrines by storm water, a shallow trench should be dug around the area occupied by the latrine. Latrines should be surrounded by a canvas screen or a screen made of shrubbery. Each abandoned latrine should be distinctly marked. Soakage pits.—Soakage pits are one of the greatest developments in impro- vised sanitary appliances. 538 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY These pits are designed for the ultimate disposal of liquid wastes, urine, sullage water and ablution water. These sanitary expedients should be con- sidered in the establishment of semipermanent and permanent camps. Ant heaps, or nests of other termites, have been used as ready-made soakage pits, and have been found capable of absorbing 300 gallons of waste liquids in 24 hours. Figure 137.—Urine soakage pit (Modified from “Lcleon") Urine soakage pits.— (a) Dig a pit 4 feet square and 4 feet deep, fill to within 6 inches from surface with large stones, or empty perforated cans. (&) Insert 4 pieces of iron piping, 1 to 2 inches in diameter, and 4% feet long at each corner of the pit, so that the upper end is at a convenient height above the ground to serve as a urinal. If iron piping is not available, long tin or tar-paper funnels may be improvised for this purpose. (c) Cover stones with oil-soaked burlap sacking, tar paper, or other material. (d) Fill over burlap with earth. (e) Insert replaceable tin funnels in iron piping—preferably with screening over apex of funnel to catch cigarette butts and other debris. if) Surround urinal pit with white-washed stones to render it more visible at night. (g) A vent leading into the pit may be constructed to give exit to the gases of fermentation and putrefaction. (h) In porous soil, one urinal soakage pit will dispose of the urine of 100 to 200 men for an indefinite period. (Fig. 137.) FIELD SANITATION 539 Night urinals.—If the urinals are located some distance from the camp, it is a temptation to a man desiring to evacuate his bladder, particularly on a cold night, to urinate upon the adjoining tent, and so on down the company street. To overcome this tendency, urinal cans should be placed in the com- pany streets at night, with a lighted lantern to mark the location. The cans used for urinals should be cleaned and sunned during the day. A more simple type of night urinal can be improvised by making a hole in the center of the tops or garbage containers and placing the inverted tops over the garbage cans. Sullage pits.—The sullage pit is for the disposal of water from kitchen garbage. These pits are 4 by 4 by 4 feet. They should be fitted with grease traps to remove the grease which tends to clog the interstices of the soakage pit. Figure 138 shows a combined soap and grease trap. Provide a sullage pit for each 200 men. Figure 138.—Waste water and grease trap. In very temporary camps, sand and gravel placed in a can or bucket with perforated holes at bottom will serve to remove the major portion of the grease. The improvised bucket grease trap may be placed over the open soakage pit filled with stones. Ablution pits.—If the ablution water is run through a box of fine sand, before entering the soakage pit, the major portion of the soap is removed. Ash barrel grease trap.—An ash barrel grease trap is prepared by using a barrel of about 50 gallons capacity with 1 head removed, and boring 30 one-inch holes in the remaining head. Place about 8 inches of gravel or stone in the bottom, the size of the stones decreasing from 1 inch at the bottom to % inch at the top, and over this place 16 inches of wood ashes. Fasten a piece of burlap over the open top of the barrel by means of a hoop. The trap may be placed directly on the soakage pit or on an impervious platform which drains into the pit. The sullage water is poured into the barrel through the burlap, food particles thus being strained out. As the greasy, soapy water filters through the ashes the greater part of the grease and soap will be removed. The burlap should be 154294°—39 35 540 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY removed daily and burned, and it will be necessary to replace tbe ashes every 3 or 4 days. When more than 200 gallons of water per day are to be disposed of, additional soakage pits and grease traps may be necessary. One barrel grease trap should be provided for each 200 men. Disposal of garbage to farmers.—It is sometimes possible to dispose of the kitchen refuse by contract with the farmers in the vicinity to haul it away to use as food for hogs, poultry, etc. This method of removal is satisfactory at times, but at other times it will be found difficult to induce the farmers to remove the garbage at regular intervals, which allows the waste to accumulate and become a nuisance. Under these circumstances it is frequently advisable to resort to other means of disposal and to burn or bury the kitchen garbage together with the other waste products. Small sewage disposal plant.—In the field, occasions may arise that require the construction of small sewage disposal plants. The “filter type” is recom- mended as simple and easily constructed. This type embodies the essential charac- teristics of the method of sewage treatment known as intermittent sand filtration.” 1. Excavate a circular pit not less than 5 feet deep and 8 feet in diameter. 2. Line the pit with a wall of stones, old bricks or other suitable material laid up without mortar in joints, leaving a space between this wall and the wall of the pit. 3. Fill in the space between this wall and the natural soil with coarse sand and gravel. 4. Fill in pit with fine gravel to provide a filter bed of at least 30 inches depth and allow 6 inches between bottom of soil pipe and top of filter bed. 5. Construct a suitable roof and sod over it. It is essential for successful operation that the water level be kept well below the surface of the filter, and in rare cases where the soil is nonporous, often joint subsurface drains should be installed. Incineration of waste products.—Incinerators used for the disposal of waste products may be divided into two types, open and closed. Characteristics of the open type are that they are easily constructed, require less material for construction, and are practical for use in semipermanent camps; character- istics of the closed type are that they are more quickly started, are not so liable to be put out by rain, are not so productive of bad odors, produce more heat, and are practical for use in permanent camps. An example of the open type is the rock pile incinerator which is constructed as follows: Dig a circular pit 15 feet in diameter and 8 feet deep; line the pit with boulders or mashed tin cans. In the center of the pit raise a pyramid of stones about 5 feet high which will serve to create a draft. A fire is built around the pyramid of stones and the garbage is later thrown on the pyramid where the solid matter is consumed and the liquid is evaporated by the hot stones. One cord of wood will consume about 4,000 pounds of ordinary camp refuse, after the stones have been heated. A closed-type incinerator to dispose of all types of kitchen garbage in per- manent and semipermanent camps may be constructed as indicated in the accompanying diagram (fig. 139). This incinerator should be constructed about 200 feet away from the kitchen, and in a location where prevailing winds are least liable to blow smoke toward the camp. It is advantageous to build the incinerator in a small grove of trees, if available. Trees serve as a wind- break, preventing scattering of papers, ashes, etc., and aid in carrying the smoke upward. 541 FIELD SANITATION The incinerator is fueled by logs, the fire hottest at the middle and lower end, to prevent “burning out” and warping of the iron plate. Wet garbage is deposited on the plate near the stack where it steams and dries slowly; agitation wuth a rake hastens drying. Portions which have become sufficiently dry, and large chunks of material, are raked over on the iron rods where they are burned and fall into the fire box. All but objects such as tin Low stack to prevent too much draft. CROSS SECTION OF FLUE Figure 139.—Incinerator for permanent and, semi permanent camps. cans, etc., are reduced to ashes, which may be cleaned cut occasionally and dis- posed of, preferably by burying. An incinerator of these dimensions should be large enough to dispose of all the waste in a camp of about 100 or 200 men. Disposal of carcasses of animals.—The labor involved in burying a dead animal is considerable, consequently a combination of burial and burning is recommended. A hole is dug beside the body, which is then disemboweled and the internal organs are buried. The disemboweled carcass is then covered inside and outside with 30 to 40 lbs. of dry hay, or other litter, saturated with kerosene, and set fire to. This 542 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY method aims at sterilization of the carcass and not incineration. If sufficient fuel, time, and labor are available, complete incineration of the carcass may be accomplished. Manure disposal.—There are several methods for the disposal of manure, a few of which will be discussed. Distribution method.—This method is applicable only in warm weather. The manure is spread in a thin layer on hard level ground, care being taken not to have the layer more than 1 inch in thickness. It is raked over a few hours later and all small lumps are broken up. This rapid drying method prevents fly breeding. The manure of 500 horses will require an area of 25 by 25 yards, and three such areas used, one every third day in rotation. Close packing.—This method is also known as the “bio-thermic” method of manure disposal. In it the mahure is moistened with water and closely packed by gradually adding new manure and beating the pile with shovels. The center of the pile undergoes fermentation and heat of more than 150° F. is generated, which heat is sufficient to destroy the eggs and larvae (maggots) of flies. Flies lay eggs only in fresh manure which is damp, and do not lay eggs in fermenting manure or dry manure. Eggs which are laid in fresh manure hatch within about 24 hours and the maggots migrate away from the hot center of the pile to the cooler outer layers, because contact with heat of fer- mentation kills them. When the larvae of the domestic fly are exposed to a heat of 122° F. they die in about 3 minutes. The gases of fermentation kill them in about 1 minute at 124° F., in about 4 to 8 seconds at 139° F., and in from 4 to 6 seconds at 140° F. The daily amount of manure produced by one horse is from 1 to 2y2 bushels. Because of the fact that flies lay their eggs in manure, maggot or larvae traps are often used in connection with the disposal of manure. Concrete basin to catch maggots Figure 140.—Fly larvae trap. Maggot trap.—The manure is stored on an elevated platform composed of parallel slats, underneath which is placed a receptacle containing water or some insecticide solution. The pile is exposed, thus encouraging flies to lay their eggs. The eggs hatch into maggots, and the maggots burrow through the pile in search of earth, with the result that they fall between the slats into the solution below, where they are destroyed. (Fig. 140.) FIELD SANITATION 543 Larvse traps have been designed for use in manure heaps. Empty tin cans with slits of a sufficient size to admit maggot forms are filled with dry hay and sunk into the manure pile so that the slits are flush with the surface. The larvae seeking a dry spot for pupation crawl into the tins and are later destroyed by burning. Several thousand larvae have been caught in this type of trap in 1 day. Incineration of manure.—When the manure is not used as fertilizer, a wire hammock may be improvised and slung between two trees. The requisites are an amount of heavy wire, a pair of wire clippers, and some ingenuity. The manure is thrown on the hammock and burned. The hammock may be swung with a pendulum motion in order to increase the draft, which will facilitate the destruction of the litter. The hammock incinerator was devised at Quantico, Va., and proved a very satisfactory method for the destruction of manure of several hundred horses and mules. If the number of horses is small, an old wire bed-spring may be used as a hammock incinerator. Another useful method of manure incineration is to place the manure in piles about 2 feet high—known as windrows—sprinkle with oil and burn. Rails from railroads may be used to construct an incinerator for the cremation of stable refuse. Persistently wet weather may delay or prevent the burning of manure for some days, and during the rainy season in some countries incineration becomes impracticable. Manure enclosure with maggot trap.—For cases where the manure is to be stored for some time and later used as fertilizer, there has been devised a manure storage receptacle with a trap to catch larvae. This is somewhat similar in principle to the maggot trap. A screened enclosure, 4 by 4 by 4 feet, is erected over a concrete base, surrounded by a trench with overhang to catch and retain fly larvae. The fly larvae are fed to chickens, or destroyed by hot water, or chemicals. The trench is connected with a small sump, in order to keep the trench dry. The wetted manure is packed tightly in the wire enclosure, and the fermentation of the organic matter generates heat, so that the fly larvae, not being able to with- stand the interior heat, come tumbling out through the meshes of the en- closure and fall into the maggot-retaining trench below. FIELD MEASURES FOR INSECT CONTROL The human race is at constant warfare with hordes of visible enemies— insects, which frequently act as carriers of myriads of invisible foes, pathogenic organisms, and ova of parasites. This is especially true of conditions in the field, and for an expeditionary force to withstand successfully the attacks of insects requires detailed consideration of field measures for insect control. Flies. The question of fly control is of tremendous importance in the prevention of disease in the field, so extended remarks on the life history are appropriate. The development of the fly by metamorphosis has been described on page 447 in the section on Hygiene and Sanitation. The egg must be kept warm if it is td develop, and it is therefore usually laid in vegetable or faecal matter which is about to ferment, the rapidity of chemical changes therein supplying the needed heat. The larva of the fly has no digestive glands, and is therefore dependent upon predigested food or other readily assimilable food—another reason for the fly depositing its egg in faeces. Its most interesting habit is that of bur- 544 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY rowing. It does so first to reach moister areas of its habitat; if disturbed, it hides with great speed; finally, in the prepupal stage, it comes to rest an inch or two beneath the surface of the ground in the vicinity of its feeding place. Having reached this haven its skin contracts, hardens, and darkens, thus form- ing the pupa-case within which the change to the perfect insect takes place. The pupa remains without food for 4 days while developing into the adult fly. To enable it to escape from the pupa-case and force its way to the surface of the ground, the young adult is provided with a temporary structure, in the shape of a dilatable frontal sac, the so-called ptilinum, the first use of which is to pry open the anterior end of the pupa-case. The young adult then emerges, and will escape through a depth of 6 inches of loose soil, and even through 6 feet of dry sand—the latter being a truly heroic effort. Anatomy of the fly.—The adult fly has the following anatomical points of interest: It is provided with a nonpiercing, retractile proboscis through which food is sucked by the powerful pharyngeal muscles. The salivary, glands are large, and saliva is freely expectorated onto dry foods, which are thus dissolved prior to ingestion. The alimentary tract is provided with no other digestive glands. In addi- tion to the stomach, the insect has a large crop capable of holding a 4 days’ reserve of food. The hairiness of body and legs is remarkable. The feet are provided with minute hairs, bristles, terminal claws, and adhesive pads. The latter consists of surfaces covered with multitudes of fine hairs, and moistened by a glairy, sticky substance, by means of which the fly maintains its foothold when inverted. For the conveyance of organisms in vast numbers, it would be difficult to imagine a more suitable apparatus than the fly’s foot. Habits of the fly.—Having had no food for 4 days, the emerging adult fly is so hungry that it seeks the nearest feeding ground, and gorges up to 70 per cent of its weight at a single meal. Its preference for certain foods is dictated by anatomical considerations. It must either get soluble carbohydrates or predigested protein; the former from kitchens and swill tubs and the latter preferably from faeces. When both sources are available, the latrine and kitchens are frequented alternately, hence the danger in the field from flies transmitting intestinal diseases. When resting, the fly can often be observed to regurgitate crop contents, until there is suspended from the end of its proboscis a drop nearly as big as its head. This fluid is drawn in and out with gusto so long as the fly is undisturbed, but is dropped if alarm leads to hasty flight. A cropful of fsecal fluid may thus be deposited on the surface of food ready for human consump- tion. Well-fed house flies evacuate their bowel about once every 5 minutes. A fly will go upward through a hole, but seldom downwards, and this fact is utilized as a principle in the construction of some flytraps. Flies endeavor to avoid strong sunlight and tend to congregate in shady places in room light. They likewise avoid a dark place, hence lampblack is used, as a fly deterrent, to cover the interior of latrines. These insects have a tendency to rest upon vertical rather than horizontal objects; they also prefer curved surfaces rather than plane surfaces. The lat- ter two facts are utilized to catch the adults by suspending curved strips of fly-paper from the ceiling. Flies tend to select certain colors and shades of color. They prefer a lighter shade to a dark one of the same color and have a tendency to avoid blue colors. Flies can travel long distances—100 miles or more. FIELD SANITATION 545 A temperature of 120° F. is usually fatal to flies; they are most active at a temperature between 80° and 90° F. and are torpid at 50° F. Prevention of fly breeding.—Flies breed in horse manure, excreta, decaying organic matter, and even in dirty rags and paper. One neglected stable may supply a horde of flies for an entire district, as a cart load of manure may harbor as many as 200,000 maggots. Chickens feed freely on fly larvae growing in manure, and it has been claimed that six chickens per horse will keep down flies around a stable. Garbage should be1 kept in covered containers to prevent fly breeding and should be removed frequently, especially in warm weather. The suppression of flies resolves itself into a matter of cleanliness—organic cleanliness of the environment. Grease traps must be covered and the surroundings kept clean and dry, or larvae will develop there. The proper care of a picket line is a difficult problem. Daily removal of the manure with cleaning of the picket line and burning over of the area are only partially effective measures in the prevention of fly breeding. The heat of burning over the surface penetrates only from 1 to 2 inches of the ground and fails to kill the developmental forms which may be several inches under the surface. Digging up the picket line and saturating it with crude oil and tamping it down is fairly satisfactory. Protection of food and personnel.—It may be accepted as a maxim that the presence of an undue number of flies is indicative that food or filth is exposed somewhere in the vicinity. A marked reduction in the number of flies around the kitchen follows the simple measure of cleaning the outside of garbage cans. In a permanent camp the kitchens, mess halls, and garbage cans should be screened. In a semipermanent camp screening may be impractical, consequently dependence must be placed upon cleanliness and insect proof containers. Un- less the screening of a building is maintained in an efficient state, the use of screens is apt to do more damage than good. Leaking screens (especially cracks around the screen door) frequently convert the building into a large “fly- trap”—flies are able to gain entrance into the building through leaking screens but are unable to get out. Screen doors should be made to open outward and should be in direct sunlight, when practicable. One of the places most apt to be overlooked is the space between the bottom of the screen door and the floor, a defect which may be remedied by using extra battens. Some of the other faults to be looked for include torn screens, warped doors, improper closing of doors, broken door stops, etc. Destruction of flies may be accomplished by the use of muscicides, fly paper, fly traps, by swatting, etc. Of the muscicides the following is very effective and is easily prepared: Formalin (solution of formaldehyde), 50-60 cc, or about 3 tablespoonfuls. Sugar, 20-25 Gms. Filtered limewater, 250 cc. Water, add enough to make 500 cc. The effect of this solution will not be very satisfactory in a humid atmos- phere. The flies should not be given access to water when this solution is used. A 1-percent solution of sodium salicylate will also kill flies. Fill a dish with the solution and place pieces of absorbent paper in it so that the paper will absorb the solution. As the solution is evaporated more must be added. 546 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY A small glass jar about half full of the solution is inverted on a flat-bottomed dish which is covered with about three layers of absorbent paper. This is a very efficient method, as the paper is always kept moist by capillary attraction. A thick rubber band placed around the jar and plate will hold the jar in position. Fly sprays are effective. The basis of these insecticides consists of pyrethrum in kerosene, or similar hydrocarbons. Use of the standard Navy issue insecticide is recommended. Fly paper is very efficient for catching flies and is prepared as follows: Heat powdered rosin 8 parts and castor oil 5 parts (by weight) ; stir well while heat- ing ; the mixture should not be brought to a boil. In hot weather the proportion of rosin should be increased. Sugar or honey may be added, but it is not essential. The fluid is spread while hot over glazed paper. The mixture may he painted upon iron hoops or wire strands. Wires so painted will last for 2 or 3 days, when they should be cleaned and recoated. Fly traps consist of wire-cone, glass-bell, and many other varieties, and are constructed on the principle that flies are attracted by the sense of smell through a dark opening in the bottom or side of the trap; after feeding they attempt to leave by flying upwards toward the light and thus into the trap. Traps should be lifted a certain distance from the ground to allow free access to the flies and should always be baited with some attractively odorous substance. Molasses in water (molasses 1 part to 3 parts of water) or brown sugar (1 part of brown sugar to 4 parts of water) may be used as bait for flies. Both of these solutions increase in attractiveness when fermented. The habits of flies should be considered in locating fly traps; 1. Flies will go from sunlight into room light, and will go from a dark room to a lighter one. 2. They congregate on the lee side of a shelter. 3. They tend to avoid certain colors, such as blue. Judging from the experiments conducted by one observer it would appear that the efficacy of fly traps is largely dependent upon the bait used in them. In these experiments 15 different kinds of bait were used and a total of 45,000 flies was caught. The following are the results of 7 of the 15 types of bait used; the results of the other 8 kinds of bait are omitted for sake of brevity. Kind of fly bait; Percent of total flies caught Pish head - - - 31.34 Overripe bananas- 21.30 Bran mixture 20.72 Canned salmon 14.00' Molasses, water, and vinegar . _ 1.00 Sweet corn - ___ _ .13 Mashes, cheese, and molasses _ - * .10 Putrefying fish, kept moist with one part molasses to three parts of water, is said to make an excellent bait for fly traps. The conical hoop trap (Fig. 141) consists essentially of a screen cylinder with a frame made of barrel hoops, in the bottom of which is inserted a screen cone. The height of the cylinder is 24 inches, the diameter 18 inches, and the cone is 22 inches high and 18 inches in diameter at the base. The apex of the cone is then cut off to give an aperture 1 inch in diameter. FIELD SANITATION 547 On the basis of extensive tests, Dr. F. C. Bishopp, principal entomologist in charge, division of insects affecting man and animals, Bureau of Entomology, U. S. Department of Agriculture, reports that this trap is best for effective trapping, durability, ease of construction and repair, and cheapness of construction. Flies gaining access to kitchens and mess halls should be killed by swatting with fly swatters. Fly swatters consist of a piece of wire mesh, leather or rubber tacked to a long handle. When rubber or leather is used it should be well perforated. The free edges of the wire mesh may be covered with leather if so desired. Care should be exercised not to swat and crush flies on mess tables, serving tables, butcher’s blocks, or on any surface on which food is likely to be placed. Flies and other insects are some- times destroyed by electrocution. To do this copper wires are inter- woven alternately across an insu- lated framework and spaced one- fourth of an inch apart on screen doors. The screens are supplied with a high tension static charge of elec- tricity from a small transformer, which produces a charge of ap- proximately 3,500 volts and less than 0.05 millampere. These doors are said to have killed as many as 15,000 flies on a summer day. Mosquitoes. Different measures are undertaken in the field to combat the activities of the mosquito in the transmission of disease. Medicinal prophylaxis.—It appears to be the generally accepted opinion that the routine internal administration of quinine as a prophylaxis against malaria is of questionable value, but the treatment of malarial carriers with quinine, plasmochin or atabrine (atebrin) is an important factor in the prevention of the dissemination of this disease. Personal protection.—Screening of living quarters in permanent camps may be utilized by using mesh screen having 16 meshes to the inch for anopheles—18 meshes to the inch must be used when screening against Aedes mosquitoes. The female mosquito, which is nocturnal in its feeding, transmits the malarial germ, consequently sleeping nets are the chief means of reducing the possibility of the transmission of this disease to troops on field duty. This article of equipment is supplied by the United States Marine Corps to every individual of an expeditionary force. If the circumstances warrant, all sentinels should wear head nets and gloves after sunset. Culifuges.—Kerosene is extensively used in some of the tropical countries as a repellent to mosquitoes, and some of the essentia] oils, such as oil of citronella, have been used. (One part, of citronella to 4 parts of vaseline.) These oils have little practical value in the field as their effect will not last through one night. Figure 141.—Conical hoop fly trap. (Bishopp.) 548 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY A very good insect repellent consists of: Oleum anisi 2 drops. Oleum eucalypti Do. Oleum terebinthinse Do. Lanolin 1 ounce. Light shades of color, especially yellow, are repellent to Anopheles mosquitoes which select dark shades, especially navy blue. The Aedes mosquito prefers a dotted white surface. Mosquito destruction.—The adult mosquitoes may be killed by fumigation— burning 2 pounds of sulfur for each 1,000 cubic feet of space. Mosquitoes are infinitely more susceptible to the action of insecticide sprays than flies. The standard Navy issue insecticide is the best spray for this purpose and should be carried in stock by the supply officer or quartermaster. Mim’s culicide consists of equal parts (by weight) of phenol (carbolic acid) crystals and gum camphor. The phenol is slowly melted and then poured over the camphor, thus forming a clear volatile liquid. Volatilize 3 ounces of this mixture for every 1,000 cubic feet of space. The following formula has been reported as an excellent insecticide spray: Parts Carbon tetrachloride 1 Oil of wintergreen (synthetic) ' 2 Kerosene 97 Naphthalene—Vi pound added to each gallon of mixture. Mosquito traps and swatters are sometimes used for the destruction of adult mosquitoes. Destruction of wintering adults is said to be very effective in reducing malaria. Destruction of mosquitoes in developmental stage.—Mosquito-breeding areas may be controlled by oiling, and crude petroleum is the oil usually selected. When the mosquito larvae, commonly called wiggle-tails, come to the surface for air the oil clogs their breathing apparatus and kills them by asphyxiation. About one-half ounce of oil suffices for every square yard of water surface under normal conditions, i. e., small areas where the wind does not blow the oil aside. The application of this amount of oil once a week is sufficiently frequent to destroy each crop of larvae. It requires 10 or more days for the cycle—from the egg to the adult mosquito. For ornamental fish and lily ponds use gasoline, one-half gallon to each 100 square feet. There are several different methods for oil distribution upon water surfaces. The “knapsack sprayer” is a well known means of oil distribution, and is often utilized. The “Panama dripper” consists of an oilcan with a faucet near the bottom which allows the oil to fall on the water, drop by drop (usually at the rate of about 30 drops per minute), and furnishes a means of continuous oiling of a running stream. The “submersible oil bubbler” devised at Quantico, acts similarly to the “dripper” except that the device is completely submerged and the oil comes from below upward. The advantage of this method is that the device is less apt to be interfered with by unauthorized persons and the flow of oil tends to be more uniform and less affected by a change in temperature. These cans are removed and refilled once a week. The container is filled with oil and sunk in the stream of water. The oil, at the rate of 40 to 60 drops per minute, is released and comes to surface, forming a uniform film of oil to destroy the “wiggle-tails” of mosquitoes. (Fig. 142.) FIELD SANITATION 549 The “oilsoaked sawdust” method of petrolization (also originated at Quantico), affords a simple means of distributing oil over mosquito breeding areas. This method was worked out contemporaneously and independently by the United States Public Health Service. The oil-soaked sawdust is placed in a wire cage or in perforated boxes which are partially embedded in running streams. The cages were found to be effective without renewal of the oil for a period of from 2 to 3 weeks. Oil-soaked sawdust can be placed in paper bags, which are thrown into marshy vegetation. The bags rupture and liberate the sawdust, the particles of which give a widely distributed film of oil, scattered throughout the aquatic vegetation. Where there is dense surface vegetation, such as water lilies, the oil-im- pregnated sawdust may be thrown at random among the vegetation and float- age ; each individual par- ticle becomes a means of slowly liberating oil. The Panama larvicide consists of phenol (car- bolic acid), rosin, and caustic soda combined in such a manner that the product has approximately the same specific gravity as water. This larvicide has the advantage over oiling inasmuch as it kills the larvae of one species, Mansonia titilans, which does not come to the sur- face of the water but gets its air from the roots of water plants. One part of this preparation to 5,000 parts of water will kill larvae. Other chemicals, some of which are byproducts in the manufacture of gun- powder, have been employed as larvicides. Arsenic dusting by hand, or air- plane, is a more recent development. Drainage and filling.—Where the mosquito-breeding area is below sea level and cannot be drained, it may be flooded with salt water to prevent breeding. In other undrainable areas deep canalization may be used to reduce the water surface to a minimum, which may then be easily controlled by oiling. Small swamps and marshes may be filled with dirt, ashes and debris. A comparatively small amount of stagnant water will furnish sufficient breed- ing area to infest a small camp with mosquitoes. A camp located about a mile from mosquito-breeding areas is considered fairly safe from Anopheles. In the selection of a camp site one should endeavor to avoid the proximity of habitations, as these dwellings are apt to harbor mosqui- toes and human malaria carriers. Figure 142.—Quantico type of submersible oil bubbler. 550 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY All tin cans, broken bottles, and other receptacles which will retain water should be immediately disposed of to prevent their use as breeding places, and rain barrels and fire barrels should be checked constantly for wiggle-tails. Even the foot prints of horses and men have been found to contain wiggle-tails in regions where water does not evaporate quickly after a rain. Biological barriers.—It has been demonstrated that Anopheles mosquitoes do not travel far from breeding places if a food supply is close by, which fact may be taken advantage of in the use of “biological barriers.” By establishing the corral and stables between the camp site and mosquito-breeding areas the animals provide a source of food for the mosquitoes whose flight in search of food is thereby stopped and the animals act as biological barriers. Mosquito control by airplane dusting.—This method is advisable when mos- quito breeding in large areas of swamps and low, marshy ground must be pre- vented. The larvicidal mixture commonly used in this way consists of 1 part of Paris green and 4 parts of powdered soap-stone, the mixture being dusted in the proportion of 5 pounds to the acre. Lice. Various methods are employed for delousing purposes. “N. C. I.” powder, which is considered very efficient in the destruction of lice, consists of the following: Naphthalene, 96 parts; cresosote, 2 parts; iodoform, 2 parts. This powder is dusted inside of wearing apparel, care being taken to avoid the forks of trousers, as this preparation, if used too freely, is an irritant to the perineal region and may cause a dermatitis. After the use of this mixture the soldier should wrap himself up in a blanket in order to retain the fumes which are generated. “Vermijelli” is less irritating than N. C. I. powder, and is composed of the following ingredients: Crude mineral oil, 9 parts; soft soap, 5 parts; water, 1 part. This preparation will kill adult lice but has no effect on the eggs. Clothing may be deloused by immersion in kerosene or gasoline. Ironing of clothes will kill both the adults and the eggs; steam heat will ac- complish the same purpose. The “Serbian barrel” and the “sack disinfestor” are two simple methods of using steam heat in the field. The Serbian-barrel disinfestor consists of a barrel with a perforated bottom and a tightly fitting removable cover which is weighted down with stones. The barrel is placed over a tank of boiling water; the steam generated from the boiling water flows under pressure into the barrel. The water must be kept boiling at all times while this barrel is in use. Clothes and other articles may be disinfested by these means. The sack disinfestor depends on the principle that steam entering the upper portion of the inverted bag displaces the air in its course downward and produces an extra atmospheric pressure (about 15 pounds per square inch) which pres- sure in turn raises the temperature of the interior of the sack to 107° C. The sack disinfestor is useful for disinfection and disinfestation. For the destruction of the head louse, acetic acid in 10-per cent solution is applied. Equal parts of kerosene and olive oil are sometimes employed in place of the acetic acid solution. The hair should be combed with a fine-tooth comb. The methods for the destruction of pubic lice are well known and will not be considered here. Bedbugs. There are two species of bedbugs, namely, the Cimex lectularius (Acanthia lectulai'ius) and the Cimex rotundata, the former being the common bedbug FIELD SANITATION 551 found in the northern climates while the latter is found in the tropical regions. The eradication of this parasite, especially in the tropical regions, is a very difficult problem. Fumigation provides very effective extermination. It is a method to be employed primarily in sealed spaces. Carboxide gas is highly recommended. Hydrocyanic-acid gas is equally efficient but should he employed only by personnel skilled in its use. The blow-torch is effective when applied to the cracks of metal beds. Kerosene, gasoline, and other chemical insecticides may be poured into crevices to exterminate this pest. Heating rooms and even entire buildings to a temperature of 120° to 125° F. for several hours will completely eliminate bedbug infestations. Superheating has been resorted to repeatedly with success during hot summer weather when advantage can be taken of the normally prevailing high temperatures. In sum- mer, most home heating equipment is sufficient to raise the temperature of in- fested rooms to 120° to 125° F., if not higher, without harm to the furnishings. It is well to place thermometers in various parts of the room or rooms in order to note the temperature obtained. The temperature in the cracks where the bugs are secreted must be held as high as 120° F. for several hours. In loosely constructed frame buildings it may not be possible to secure a killing temperature at points close to wall spaces. Cockroaches. There are four domesticated species of this family, namely, the Oriental, German, American, and Australian. Sodium fluoride blown in corners and crevices is a standard poison for this pest. The roaches walk through the powder, some of which adheres to their legs, and are killed by the sodium fluoride when it gets into their mouths, as they clean their legs with their mouths. The use of sodium fluoride is not without danger around a mess hall as it may be mistaken for sodium bicar- bonate, baking soda or powdered sugar. Roaches may carry it to food. It is highly toxic to humans. Another cockroach poison consists of dry plaster of Paris, 1 part, flour, 3 parts. When using the above mixture a dish containing water should be close by. The insect, after feeding upon this preparation, becomes thirsty and seeks water which sets the plaster of Paris and kills by clogging the intestine. Pyrethrum is extensively used as an insecticide for the extermination of cock- roaches and other insects. It is incorporated in the Navy issue liquid insecti- cide. Fleas. Pyrethrum powder is effective for removing fleas from the body. Iodoform and oil of pennyroyal act as repellents. An emulsion of 5 per cent cresol, with or without soft soap solution (20 per cent), gives excellent results. Sprinkling a flea-infested floor with flaked naphthalene and closing the room for 24 hours is very effective. A solution of naphthalene in gasoline should be poured into all holes—such as mouse holes—in the treatment of plague-infested houses. 552 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVA Military value of marching. The ability to march has always been—and the results of the World War tend to show that this is still true—one of the determining factors of victory. The superiority in marching ability of troops enables the responsible comman- der to secure the preponderance of men at the critical time and place. Infan- try, in spite of the rapid development of other branches of the military service, is still the dominant arm. To be able to endure long marching requires careful training and attention to a host of trivial details. According to the Field Service Regulations, United States Army, “Good marching is secured by careful preparation, strict discipline, and observance of march sanitation.” Physics and physiology of the march. Physics of the march—A soldier weighing 160 pounds, carrying 40 pounds, and walking 15 miles at the rate of 3 miles per hour on a level surface will perform an amount of work equivalent to 353.57 foot-tons. According to Haughton, as quoted by Harrington, this labor, in walking over a level surface, is determined by the following formula: HYGIENE AND SANITATION OF THE MARCH (160a+406) X 79,200c 2j240dX20e =353'57 foot-tons- Key: a=weight of person; 6=weight carried; c=distance walked in feet; d=pounds in long ton ; e=coefficient of traction. The coefficient of traction varies for different rates of speed, with the char- acter of the terrain, and wind effect. For 2, 3, 4, and 5 miles per hour, on a level surface, it is approximately 1/26, 1/20, 1/16, and 1/14, respectively. Physiology of the march.—Compared to the steam engine the human mecha- nism is a bit more efficient, as the engine is capable of utilizing only 13 per cent of the energy from its fuel for useful work while the human body is able to utilize 20 per cent of the energy value of its diet; the 80 per cent balance goes in the production of heat which must be dissipated in order to keep the body temperature constant. The unit of energy is the calorie which has been previously explained. A soldier at rest requires 3,000 calories per day, of which one-fifth (600 calories) actually goes into work, and four-fifths (2,400 calories) is dissipated as heat. The evaporation of perspiration acts in dissipating heat of the body similar to the radiator of the automobile in maintaining the motor near a constant temperature. The evaporation of 1 cc of water reqinres 0.5 calorie, consequently the evaporation of a quart of water—(Imperial measure, 1 quart = 1,182.52 cc) — from the body’s surface will dissipate 600 calories of heat. To produce 350 foot-tons of work, such as in the example of the marching soldier, would require the expenditure of 254 calories as muscular energy. Since the body is only 20 per cent efficient the total expenditure of energy to produce this work would be 1,270 calories, of which 1,016 calories are dissipated as heat. The soldier normally expends 1,000 calories in 8 hours. Therefore, the total caloric need of the soldier during the 8-hour march is 2,270 calories, of which 1,816 calories must be dissipated as heat. Of the 1,816 calories, 30 per cent is disposed of by radiation, conduction, and convection, while the remaining 70 per cent of the 1,816 calories (equal to nearly 1,300 calories) must be disposed of by evaporation of fluids. As the evapo- 553 FIELD SANITATION ration of 1 quart of water takes 600 calories, then the total water which must be lost in this 8-hour march is approximately 2 quarts, provided the entire amount evaporates on the body surface. Effects of water loss: Miles marched Quarts perspired Soldier’s condition if water is not replaced Miles marched Quarts perspired Soldier’s condition if water is not replaced 7 VS 1 30 ... . 4 Danger. Death. 15 2 Thirst of necessity. Marked inefficiency. 45 6 22 3 The physiology of perspiration is vitally connected with heat stroke and heat exhaustion with result from failure to dissipate the excess body heat. As body heat increases due to increasing labor or to increasing ac- cumulation from the environment, a fireroom for example, the function of perspiration becomes of greater importance in keeping body temperature normal. Men should be thoroughly indoctrinated in a few simple facts: 1. Perspiration lowers body temperature only when it evaporates from the surface of the body. Evaporation is retarded when the air is still and has a high degree of humidity. Light, loosely worn clothing promotes evapora- tion by retaining perspiration on the body surface. Water of perspiration that runs off the body or is wiped off represents a loss and the amount of this loss should be added to the second column of the accompanying table. 2. The body has a comparatively small reserve supply of water and when this reserve is exhausted the body ceases to perspire. As this is the major factor that keeps the body heat normal, heat stroke or heat exhaustion follows. Therefore, water loss should be promptly replaced. 3. Furthermore, ordinary table salt is an essential factor in control of body temperature. The body can neither absorb nor perspire salt-free water. The reserve stock of this salt is limited. When this reserve is exhausted the body will cease to perspire even if the supply of water in the body is ample and it will not absorb water from the intestinal tract even though large quantities are drunk and there is great need for water. This con- dition of insatiable thirst and diarrhoea can be corrected by adding salt to the water. Prophylactic treatment consists of supplying salt to men perspiring excessively. Preparation for the march. It is remarkable to note what improvement in marching ability can be effected in a few weeks of graduated exercise and muscular training. One investigator conducted a series of experiments on an untrained man marching a certain distance in a given time with the following results: Untrained After 3 weeks’ soldier training Increase in pulse beats-- 72 28 Increase in temperature, °F . - . 2.2 0.6 Loss of weight --. pounds.- 2H 2 H Men should be trained in marching by increasing the length of the hike and the weight of the pack. They should be so trained for several months. This training means the development of all muscles in the body—an increase 554 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of capacity of the lungs and heart, also strengthening of the foot arches, and the like. It is at this time that the medical officer should keep close super- vision over the men. Overtraining defeats the purpose and leads to cardiac dilatation and eventually to exhaustion. Men under training should be given periods of mental and physical relax- ation and recuperation. It is remarkable how quickly the human mechanism develops with progressive and systematic exercises. The raw recruit under proper supervision shows rapid development within a few weeks of training. The men should be trained to breathe through the nostrils, as in this way dust and other foreign bodies are removed from the air before it reaches the lungs, and the air is warmed. Mouth breathing tends to dry the mouth and thus increase the sensation of thirst. A person marching at the rate of 4 miles per hour inhales five times as much air as when reclining. Conduct of the march. The most suitable time to start a day’s march is 1 hour after the break of day. Night marching should be practiced only when military necessity demands, and then should begin soon after sunset. The canteens should be filled preferably the night before the march. The sick and the physically unfit should be eliminated at the morning sick call. By all means avoid premature assembly of the men—get them “under way” as soon as practicable after “falling in.” A light breakfast should be served. The sanitary officer, with a police detail, remains for a few minutes after the camp is cleared to see that all waste and litter are disposed of, latrines filled in and labeled, and that the camp site is otherwise left in a clean and sanitary condition. Rate of march.—The human mechanism—similar to the automobile motor— must be warmed up before it can function at its best in marching. The physiologically best temperature for the body in marching is 100.5° F. and 102° F. is the maximum temperature before serious symptoms become noticeable, such as swaying, tremor, nervousness, etc. Thus there is only 1.5 degrees range between the optimum body temperature and danger body tem- perature “and this narrow safety margin indicates alike the delicacy of the adjustment mechanism and the importance of every means of aiding that adjustment.” A horseman always starts his horse off slowly, and the end of the ride is made at a slow pace. Likewise the infantry leader should start his men off slowly so as to warm up, and the last few minutes should be at a slow pace for the men to cool off. Always avoid the tendency to the final spurt in nearing evening camp. The ordinary Marine Corps shirt holds a pint of perspiration, when satur- ated, this is equivalent to 300 calories, which energy can be conserved by the simple expedient of slow marching at the end of the day. This permits the moisture to be evaporated on the body during the marching period when the cooling effect serves a useful purpose. The march should be completed with a nearly dry shirt to prevent a harmful chilling effect during the following rest and recovery period. The rate for infantry is 100 yards per minute. To maintain this speed, one hundred and twenty 30-inch steps are required, which gives an actual rate of 3.46 miles per hour (exclusive of rest periods). This may be regarded as the 555 FIELD SANITATION most economical speed for experienced troops. For unseasoned troops and for longer hikes, the economical speed is a slower cadence. With a speed of 3.46 miles per hour for the day’s march, if the rest periods are included, from start to end of the march an average of 2y2 miles per hour is considered the maximum expected of foot troops. Double time is a 36-inch step at the rate of 180 steps per minute, and should never be used in routine marching. In route step, there is no standard stride or cadence, and the men are out of step, which is often a restful variation. The marching column varies with route step, marching in time, and marching to music or singing. Mechanics of marching.—Mathematical calculations show that in marching the best mechanical advantage is obtained by a stride the length of which is six-sevenths the length of the leg. The stride is a pendulum motion. The correct position for head and limbs in marching corresponds to the attitude one assumes when about to ascend a flight of stairs. The proper load for an infantryman should not exceed one-third of the body weight, or 50 pounds for a 150-pound man. The maximum is 45 per cent of body weight or 67 pounds for the average man, and any increase above this 67 pounds causes expenditure of energy to be increased three times as rapidly as the weight of the load. The load should be adjusted near the center of gravity of the body, i. e., in the erect position 0.6 cm in front of the line connecting the femoral heads and opposite the center of the third lumbar vertebra. The chest or abdomen should not be constricted by the load and the load should be borne by the shoulders and back. March formation.—If there is much traffic on the road the marching column should keep to the right and proceed in squad formation. If circumstances permit, it is much better to march in open ranks, half on each side of the road, which order tends to decrease the heavy oppressive cloud of dust, foul odor, and water vapor from perspiration which tend to hang over close-order formation. The taller men at the head of the column are apt to set a pace uncomfortable to the shorter men marching in the rear of the column, and it is also easier marching at the head than in the rear, consequently the column should be reversed from time to time. The rear files as a rule expend about 6 per cent more energy than those at the head. Halts.—The first halt should be after 30 minutes of hiking, and should be for a period of 12 minutes. The object of the first halt is to permit the men to get their “second wind,” adjust shoe laces, rearrange packs, and to attend to the calls of nature. The succeeding halts are made every 50 minutes and are for a period of 10 minutes rest, except for the halt for the noon meal, which is for 1 hour. During the rest periods the men should remove their packs and lie upon their backs. Their coats should be replaced and unbuttoned to avoid undue exposure to drafts and winds. An endeavor should be made to halt in cool, shady places, protected from strong winds. A place should be provided for the men to attend to the calls of nature during the rest periods—shallow trenches dug with a bayonet or sharp stick will suffice for this purpose. Endeavor to select locations for halts that have the following character- istics : Clean and dry; sheltered from the sun; and privacy. 154294°—39—36 556 HANDBOOK OF THE HOSPITAL CORPS, XI. S. NAVY If practicable avoid baiting the column in towns, villages, or near habitations. Massage and kneading of the muscles of the legs during halts helps free them of accumulated waste products and prevent stiffness. In difficult and mountainous country the halt periods should be more frequent. The order should be given to “remove packs” within 30 seconds after a halt— any unnecessary delay irks and irritates the marching organization. Length of march.—The length of the day’s march is not measured by miles, but according to the condition of the roads, the weather, the pace, the weight of the loads, experience and physical condition of the troops, etc. Miles per day Average for large body of infantry 12 Average for small body of infantry 15 Any distance beyond the above is regarded as a forced march. Wagon trains march about as rapidly as foot troops. Artillery covers 15 to 20 miles per day. Morale.—A fatigued body causes a hypersensitive state of mind, which is more susceptible to real or imaginary adverse stimuli. To inhibit the action of these stimuli calls for resourcefulness and leadership in company officers. One com- pany under proper leadership will arrive in the evening camp, tired, but happy, whereas another company, not so fortunate in the selection of company officers, is apt to come into camp tired and dissatisfied. Singing and whistling of popular tunes should be encouraged, as this distracts the minds of the men from their fatigued state, and is one of the surest means of preventing them from succumbing to exhaustion. Straggling, either from poor discipline or fatigue, is always to be avoided, as it is depressing to the morale of the entire body of troops. Night marching.—Marching at night should be permitted only for strong tac- tical reasons, as marching at this time interferes with the sleep routine; in the darkness men cannot be sure of their footing and accidents may occur. Marching in the tropics.—In warm countries the march should be started earlier, shortly after daybreak, if practicable. Marching in the middle of the day should be avoided by a midday rest period of 2 to 3 hours. Green leaves or a wet handkerchief in the hat serve to protect the head and neck from the sun’s rays. It is particularly necessary to open up shirt fronts and roll up the sleeves. Tests with a dry and wet bulb reading 79° F. and 67° F. were conducted on an organization hiking 7 miles and the men were found to lose an average of 3 pints of water. But with shirts opened and sleeves rolled up the loss of fluid was reduced from 3 pints to 2 pints in marching the same distance under the same climatic conditions. In warm countries the loss of heat by radiation is generally very rapid after sunset, consequently a fall in body temperature and a chill results if the men are wet with perspiration and not given time to cool off gradually before halt- ing for the night. An endeavor should be made to detect early appearance of symptoms of heat stroke which frequently occurs during hot weather marches. The treatment is: 1. Loosen all clothing. 2. Remove patient to shade. 3. Strip to waist. FIELD SANITATION 557 4. Fan patient. 5. Apply ice bag or cold water freely to head, neck, and spine, and con- tinue until symptoms subside. 6. Eestore body chlorides by administering salt. Water discipline on the march. In marching 1 mile a fully equipped soldier generates 90 calories which will require the evaporation of 180 cc of water to dissipate the heat. For 3 miles, or 1 hour of hiking, he will require 540 cc of water, which is a little over one pint (473 cc) and for 2 hours of hiking the soldier will lose 2 pints or the equivalent of one canteen of water. In interpretation of the above, it must be remembered that the water require- ments are based upon the climate of middle and western Europe. In a hotter and drier climate, a larger amount of water should be used. There are so many factors entering into the water requirements that any attempt to be dogmatic or standardize the fluid intake for the marching soldier is apt to result in more damage than good, if a standard is too rigidly adhered to. It is safe, however, to use the following as a guide, since the soldier starts the march with about 1 pint of extra fluid in his stomach: Drink 1 pint, half the contents of the canteen, for each hour of marching, including rest periods, the marcher to take the first drink at the end of the second hour after leaving camp. The following table shows how the water requirements of a man on a day’s march may be met: Start of march First hour Second hour Third hour Fourth and fifth hours Sixth hour Seventh hour Eighth hour Ninth hour Leave with 1 pint in stomach. Drink Vi canteen- ful. Drink re- maining Vi canteen- ful. Noon rest. Refill can- teen. Leave with 1 pint in stomach. Drink H canteen- ful. Drink re- maining yi canteen- ful. Camp. Re- fill can- teen. As the hot climate of the tropics considerably increases the water demands of the infantryman, the above must be increased; hilly, muddy, and rough roads also increase water demands. The canteen should be used only during the rest period and then upon command. Water should be slowly sipped as thirst is quenched better. In addition to water consumed from] canteens, a pint or more is consumed with each meal. The experienced soldier has instinctively determined the proper amount of water which his system will require; it is the raw recruit who is apt to “water log” his tissues, sweat profusely, and tire easily. One type of thirst is due to dryness of the mouth, and to overcome this factor the men are advised to chew gum, or keep pebbles in their mouths, which promote the flow of saliva and tend to allay this form of thirst. Smoking on the march tends to increase thirst and should be limited to rest periods, or, as some authorities recommend, should be prohibited during the march. As a rule marching troops are accompanied by water carts containing potable water. It is most important that only pure water be used in the canteens, as the stomach of a marching soldier is apt to contain insufficient hydrochloric acid to destroy infective organisms. 558 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The water needs of officers are slightly less than those of men, because their equipment is lighter, and marching to one side requires less work than marching in ranks. Immediately after arriving in camp guards are posted over the water supply which is marked to show the use to be made of different portions of the running stream. A white flag indicates the portion farthest upstream to be used for drinking water; a blue flag, next downstream, the portion for water- ing animals; and a red flag, farthest downstream, the portion for bathing and washing clothes. Food on the march. A light breakfast consisting of oatmeal, tea or coffee, bread and jam, and perhaps some bacon to “stick to the ribs”, should be served before beginning a march. The food should be easily digestible. A heavy breakfast is inad- visable as digestion is interfered with by the vascular demands of muscles used in marching. Exhaustion retards digestion so that it is well to have a brief interval of rest just before the noon and evening meals. The noonday meal should also be light and digestible, and should be served during the noon rest period. Upon arrival in camp for the evening, serving soup ahead of the meal increases the digestive capacity 20 per cent, owing to the stimulation of the flow of gastric juices. The main meal should be the evening meal. Slowly-cooked stew increases the digestibility of proteins. Foods with high-vitamin content such as fruits, vegetables, or even canned tomatoes should be served, because the individual soldier in the field does not have the opportunity of supplementing his ration by outside purchases of food. In view of its rapidity of digestion and oxidation, sugar is the quickest re- storative of muscular energy. A marching man craves sweets, candies, jams, preserves, and sweetened coffee or tea. Chocolate or cocoa are excellent for restoring muscular tone. The following table furnishes data for use as a basis for calculating the food requirement of the marching man: Calories Foot tons of energy 4.1 6.3 9.3 14. 2 4.1 6.3 When marching at the rate of 3 miles per hour the soldier does work the equivalent to raising one-twentieth part of the weight of the body through the distance he walked. Work in tons lifted 1 foot Marching 1 mile __ . _ . 18. 86 Marching 2 miles __ .. _ . ... ... 37.72 Marching 10 miles . 188. 60 Marching 20 miles 377. 20 If the soldier carries 60 pounds of equipment, the foot-tons are increased 30 per cent. Carrying 60 pounds and marching 20 miles the soldier expends the equivalent to 518.60 foot-tons. FIELD SANITATION 559 Manifestly the caloric requirement of a soldier when marching is higher than when at rest. A diet of 4,000 to 6,000 calories should be planned, depend- ing on the length of the marches, rate, condition of road, terrain, weight of load carried, and other influencing factors. The use of tobacco and alcohol by marching troops has proponents and opponents. Smoking should be limited to rest periods. Alcoholic beverages should be restricted to the evening after arrival in camp and temperance must be enforced. March sanitation. Sanitary measures to be carried out while on a march are as follows : At the start.—1. Fill and chlorinate water carts; canteens should be filled the night before; 2. Police camp, extinguish camp fires; 3. Fill in, close, and mark latrines; 4. Sanitary officer and police detail remain and clear up waste and litter; and 5. Final inspection of camp site. At a halt.—1. Designate sanitary area; 2. Dig shallow pits for calls of nature, using bayonet or stick for digging implement; and 3. Refill canteens. Selection of camp site.—Toward the end of the day’s march a staff officer, a medical officer, and an engineer officer or a quartermaster should ride forward and select a camp site, unless this has been previously arranged. The functions of the medical officer are advisory in the final selection of the camp site. In time of war tactical consideration is of primary importance in the selection of a camp site. It is impracticable to locate an ideal camp site which will be entirely satisfactory from a medical viewpoint, hence the medical officer must consider the pros and cons of the available locations. Favorable consideration should be given the following characteristics: (a) Accessibility to a supply of good water, fuel, and forage. (b) Sandy loam or gravel soil. (c) Elevated site well drained, such as sloping plateau. (d) Shade trees as a protection from the sun’s rays in warm weather. (e) Hills and forests acting as windbreaks in cold weather. (f) Location large enough to accommodate the troops without crowding. (g) Grass-covered location. Unfavorable consideration should be given to: (a) Sites recently occupied by other troops, allowing 2 months’ vacancy before reuse as an arbitrary standard. (b) Dry bed of river, ravines, and base of hills if there is likelihood of rain. (c) Clay, alluvial, or dusty soil. (d) Proximity to marshes, swamps, and other mosquito-breeding areas. (e) Steep slopes. (r) Sites where the ground water is near the surface. (g) Proximity to native habitations especially in malarial regions. In camp.—1. Proper waste disposal; 2. Insect control; 3. Water inspection; 4. Food inspection; 5. Care of the feet; 6. Do not keep troops waiting in ranks after arrival at destination; and 7. Water responsibility: Its purity—medical officer; quantity and delivery—engineer officer; procurement—quartermaster; and water guards and distribution—Unit commander. Always remember that today’s camp site may be tomorrow’s line of com- munication. 560 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY MEDICAL DEPARTMENT ON THE MARCH Before starting, the responsible surgeon should see that all sick and unfit are eliminated, that the camp site is left in a sanitary condition, that the quality of water in the canteens is satisfactory, and that foot disorders have been given the requisite attention. The brigade surgeon proceeds forward on the staff of the brigade commander. The regimental surgeon occupies a corresponding place in the regiment to that of the brigade surgeon, and the assistant regimental surgeon marches in the rear of the headquarters company. The battalion surgeon proceeds with the staff of the battalion commander, and the assistant battalion surgeon marches in the rear of the battalion. If there is only one surgeon assigned to a battalion, he should march in the rear of the unit. The junior medical officers marching in the rear should occasionally proceed up and down the marching column of their respective organizations to observe the condition of the troops. Soldiers suffering from the effects of fatigue may be dropped at the march collecting stations, ride in ambulances, or they may be allowed to proceed without their equipment—their equipment may be thrown upon one of the wagons of the train. All sick and injured patients should be properly tagged with the diagnosis tag and recorded. A compilation of these records is made at the end of the day’s march. The medical battalion proceeds in two groups—one, consisting of the mounted and foot group, marching in advance of the animal-drawn train, and the other, consisting of the motor-drawn group, proceeding at the head of the motorized train of the brigade. If the marching command is composed of a brigade or larger organization, it is advisable to establish march collecting stations every 3 miles. The personnel for these stations consists of two or more hospital corpsmen, who are equipped to give first-aid treatment to the sick, injured, and exhausted, and to retain the patients until they are picked up by the ambulances in the rear of the column. The hospital corpsmen detailed for the purpose of establishing march collect- ing stations should proceed with the head of the column or advance party and drop off every 3 miles to form collecting stations. They remain until the tail of the column has cleared their station, then fall in with the rear units. Toward the end of the day’s march the necessary sanitary personnel should join the advance guard to supervise water purification and make arrangements for sanitation before the main body arrives. Combatant units of advance guards, rear guards, and other security detach- ments are normally accompanied by their attached medical troops. In view of the fact that poison ivy is a source of danger to a marching command, detailed consideration is advisable. (See Contact Dermatitis, p. 481.) Ivy poisoning is a form of dermatitis venenata due to exposure to poison ivy (Rhus toxicodendron), and the excitant is an oily compound called toxico- dendrbl, belonging to the phenol group. As little of 0.001 mgm. of toxicodendrol may produce dermatitis. All parts of poison ivy contain the irritating principle, the leaf especially. Poison ivy grows as a woody vine, trailing shrub, or erect bush, growing in the woods or in the open, in moist or dry soil. It climbs trees and posts. The plant is recognized by its leaves which are divided into three leaflets, and by its white mistletoe berries, known as drupes; the latter remain on the FIELD SANITATION 561 plants into winter after the leaves have fallen. All of these plants do not bear the drupes and it must be recognized by the leaves. The leaves are from 1 to 4 inches long. The end leaflet of the triad has a longer stem than the two opposite leaflets, which, as the leaves are broad, though pointed, preserves the symmetry of the arrangement. The mature leaves are dark green on the upper surface and lighter under- neath. The crinkly young leaves are red when they first unfold, becoming green later. In autumn they turn to beautiful shades of scarlet and orange. The innocent sometimes pluck these leaves and to their sorrow bear them off. The old adage: “Leaflets three, let it be,” is a safe rule for those who are not familiar with poison ivy to follow. The period of incubation, after contact by the susceptible, is usually a few hours but may be delayed for days. Redness and erythema appear, usually first on the face and hands. Shortly, fine vesicles, clear and closely grouped, are observed in the thinner areas, such as the inner surface of the fingers. Other areas of the skin become affected, even those where there has been no direct contact. The eyelids and surrounding tissues are frequently greatly swollen. Probably by indirect contact the genitals become oedematous and the rash has a predilection for the looser and thinner skin. As the active agent is fat and alcohol soluble, the irritant may be largely removed if immediately after exposure the areas are washed with soap and water. Alcohol or ether, used on swabs, being careful to clean the irritated areas from the periphery towards the center, is a more effective measure. Two readily available agents are recommended for the treatment of the lesions. 1. Potassium permanganate in a 5 per cent solution in water, applied locally by cotton swabs or cloths; frequent applications should be made, or if a dress- ing is used, frequent changes of the dressing. 2. Chloride of iron, a 5 per cent solution in equal parts of alcohol and water can be used in the same way. THE FOOT Anatomy and physiology. The human foot is a specialized organ designed to promote terrestial locomo- tion of the individual by leverage action of the foot in lifting the body’s weight and it plays such a dominant role in marching that a brief descrip- tion is appropriate. Considered in its entirety, the human foot is indeed a very wonderful anatomic part of the individual. In the smallness of its size and weight, out of all proportion to the burden borne and carried, it constitutes a mobile, strong, flexible, and efficient member of the organism designed to bear weight forwards, backwards, and sideways without mishap. Encased in a cloth covering, the sock, and in a protective leather covering, the shoe, both con- comitants of an advancing and exacting civilization, this member, the most unintentionally neglected part of the body, is expected to do its full duty. The foot is composed of a nicely adjusted aggregation of 26 bones of various sizes and shapes, each, however, designed to perform a certain definite function. Seven of these are of a very irregular shape and are located in the hind part of the structure forming the heel and a portion of the so-called instep. The remaining 19, situated in the forepart of the foot, form a portion of and radiate fan-like from the instep. These extend forward and to the outer and inner sides, finally ending in the toes. These different bones are held together in a correct position by ligaments, tendons, and muscles; the ligamen- 562 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tous support predominating in the posterior 7 bones which form the static portion of the foot, while muscular action predominates in the anterior 19 bones which form the dynamic portion. (Fig. 143.) The posterior seven bones, forming a compact mass held by ligamentous attachments, move very slightly when a step is taken and serve to minimize the shock of impact and act as a recoil mechanism. On this mass—the static portion of the foot—in the shod man, all the weight of locomotion is first borne; first affect- ing the heel and center of the instep. As mentioned under the Mechanics of March- ing, the center of grav- ity of the body must be considered in the carry- ing of extra equipment. When the soldier is standing, stance, stable, or static equilibrium is involved as the center of gravity is directly above the feet which act as a support. When locomotion is started as in marching, dynamic equilibrium is brought into force by an active interplay between the organic energy of the soldier and the force of gravity. The feet function as a series of levers that act against the body’s center. In marching the body’s center is constantly being displaced forward and gravity thus assists the for- ward translational motion through its influence upon the imbalanced body weight. The walking man, so to speak, tends to fall forward at each step, until this action is interrupted temporarily and the body is balanced momentarily by one foot as a support. The marching soldier always has one foot on the ground. Man, more often than any other animal, in upright bipedism, makes better use of gravity as an auxiliary force in locomotion. Care of the feet. It is difficult to overemphasize the value of the proper care of the feet. It is said that during the first days of a campaign 10 to 25 per cent of the men are physically disabled from foot troubles. Of course the prevention of the foot injury while marching depends upon properly fitting shoes and socks. Shoes.—According to the Duke of Wellington, the three most important parts of a soldier’s equipment are a pair of good shoes, a second pair of good shoes, and a pair of half soles. A common mistake of the recruit is to call for the same size shoe worn in civil life. With the noticeable difference in the last of the military shoe, es- pecially its width, the man will receive a shoe perhaps three or four sizes too short, and in a few weeks will develop some form of sore feet. To obviate these common mistakes the feet must be measured by an officer, the man must Figdee 143.—Bones of the foot. FIELD SANITATION wear his full equipment to cause full expansion of the feet, and the inner surface of the shoe must he a quarter of an inch longer and wider than the foot. New shoes should not be worn on the march unless they have been broken in. An excellent method of adapting new shoes to the foot consists in the soldier standing in his shoes in 2 inches of water for 5 minutes. This makes the leather soft and pliable. The man then walks on level surface about an hour, and the pressure of the body weight causes the drying leather to conform to the shape of the feet. This scheme accomplishes in an hour what a week of ordinary “breaking in” can produce. Socks.—It is equally imperative to wear properly fitting socks, and the proper sizes to be worn with the required length of shoe are given in the sub-joined table. Light woolen socks in summer time, and heavy woolen ones in winter, are preferable over cotton fabric. Socks too large will form folds and thus cause pressure foot injuries and if too small tend to produce ingrowing toenails, hallux valgus, and clubbed toes. Turning socks wrong side outwards, and changing socks from one foot to another equalizes wear, and is conducive to comfort. Holes in socks are apt to cause blisters as the edges of the hole tend to curl and cause pressure damage upon the subjacent skin area. Avoid using darned socks. The life of a good light-wool sock is about 100 road miles, but if feet are wet the sock will wear through much sooner. Socks colored with aniline or other irritating dyes which wash out with perspiration should not be worn; gray or white being preferable. Ribbed socks are better than plain ones, as they are more elastic and fit the foot better. Shoe Size: Corresponding sock size 5~5i/2 _ _ _ . 10 6-61/2-7 _ _ . IO1/2 71/2-8-81/2 _ _ . 11 9-»%-10 _ _ 11% 101/2-11-111/2 _ . __ . 12 12-121/2-13 _ . __ _ . _ 12i/2 _ 13 15 _ _ _ _ __ . __ 131/2 Some soldiers grease their socks or rub the feet with candle, vaseline, or nnsalted pork, and thus lessen the friction between foot and sock. New socks should be washed and shrunk before use for marching purposes. Feet.—It is also essential to keep the feet clean, to prevent abrasions and infections. The feet must be washed daily at the end of the march, clean socks should replace the dirty ones, which should be washed and dried overnight. If water is not abundant the feet can be cleaned by wiping them, particularly the toes, with a wet cloth. The following routine upon arrival in camp is recommended: 1. Remove shoes, clean, dry, and dub them. 2. Wash feet in cold water to tone foot muscles. Foot inspection by company commanders. 3. If feet are tender bathe in alcohol or 1 per cent formaldehyde solution, or 2 per cent alcoholic solution of salicylic acid, or 1 per cent picric acid solution. 4. Put on clean socks and shoes. 5. Wash and knead soiled socks for use next day. 564 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 6. Trim toenails square, so as to prevent ingrowing toenails. Another method of prevention of ingrowing toenails consists of scraping the upper surface of the toenail in center. This causes the nail to be thinner in center and leads to eversion of the outer sides of the growing nail. This method is claimed to be an effective prophylaxis. Treatment of foot disorders.—Puncture blisters at dependent portions of base, using sterile needle, remove serum, and paint with tincture of iodine. Cover blister with adhesive tape with small hole in center to allow discharge to escape. For smelly feet (bromidrosis) use 2 per cent solution of formaldehyde or apply 2 per cent salicylic acid ointment. An old custom of the soldier to lessen friction between socks and foot is to soap the inside of the sock; with the perspiration of the foot the soap becomes a lather which serves as a lubricant. Another means of minimizing the rubbing of the foot by the shoe is to wear 2 socks on each foot. In cold weather, when the feet perspire less, friction may be minimized by dusting foot powder inside the sock. This foot powder consists of: Parts Talcum (Magnesium silicate) 87 Boric acid 10 Salicylic acid 3 Chafing between the toes is cured easily by cleanliness, a small wedge of cotton separating the toes, and the application of the foot powder. Corns are treated by salicylic acid collodion or ointment applied nightly after a hot foot bath; usually after four or six applications the corn easily can be removed with curved scissors. Corn collodion consists of: Salicylic acid grains— 60 Extract of Cannabis indica do 8 Flexible collodion ounce— 1 To preserve this mixture a small amount of alcohol may be added. Corn salve consists of: Parts Salicylic acid 40 Vaseline 30 Lanolin 30 In some experienced organizations, sore feet are reckoned as a military offense both for the individual and for his company commander. Careful attention to the feet of marching men is as important as the attention bestowed on the rifle, and many foot troubles can be eliminated by the rules described. Field Sanitation.—Mann, in U. S. Naval Medical Bulletin, vol. XXXVI, no. 3, July, 1938. Hospital Corps Handbook, U. S. Navy, 1923. References Section 7.—DUTY WITH MARINE CORPS EXPEDITIONARY FORCES The hospital corpsman serving with Marines has many and varied duties. He becomes primarily a soldier and may be detailed with the medical detach- ment of the combat units; as a nurse in the hospital section of the medical eompany; a clerk in the headquarters section; or as a litter bearer in the MARINE CORPS EXPEDITIONARY FORCES 565 collecting section. He must be physically robust and capable of quickly adapting himself to all the conditions of a soldier’s life. The act of August 29, 1916, provides, in part, as follows: “Officers and enlisted men of the Medical Department of the Navy, serving with a body of Marines detached for service with the Army in accordance with the provisions of section sixteen hundred and twenty-one of the Revised Statutes, shall, while so serving, be subject to the rules and articles of war prescribed for the gov- ernment of the Army in the same manner as the officers and men of the Marine Corps while so serving.” The responsibility and functions of the medical department with Marines may be summarized as: The conservation of the fighting strength of the force. This is accomplished by: (а) Supervision of sanitation and hygiene. (б) Prevention of epidemics. (c) Management of epidemics when they occur. (d) Collection, evacuation, and hospitalization of the sick, injured, and wounded. (e) Prompt return of sick and wounded to their organization, and elim- ination of the permanently unfit. (f) Procurement, storage, and distribution of medical supplies. The medical department of a Marine Corps post is organized as follows: 1. An administrative headquarters, or post surgeon’s office with the follow- ing duties: (a) Coordination of all the medical activities. (&) Preparation and forwarding of all medical department reports and returns. (c) Preservation of medical department files. (d) Procurement, stowage, and issue of medical supplies. The post surgeon is the advisor to the commanding general on all matters pertaining to sanitation and the health of the post. 2. The sanitary inspector has the following duties: (A) Supervision of the sanitation of the post. (B) Preparation of data and charts relative to— (а) Sick rate. (б) Incidence of venereal disease. (c) Epidemics. (d) Sanitary work contemplated or undertaken. (e) Disease carriers. if) Food. (g) Water. (h) Epidemiology. (0) Maintenance of contact with local civil health authorities. 3. Dispensaries maintained in each brigade area with a medical officer in charge who keeps health records of brigade personnel; provides temporary care of the sick and Injured; instructs his subordinates in first aid; advises the brigade commander on matters affecting the health of the organization and instructs the brigade personnel in personal hygiene and first aid. 4. A sick quarters maintained to furnish hospital treatment for the sick and injured and similar to a naval hospital in organization. 566 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY THE FLEET MARINE FORCE The Fleet Marine Force is a highly mobile body of troops composed of infan- try, artillery, engineers, and aviation groups, created for employment as a component unit of the United States Fleet and kept in the same state of readi- ness as the other units of the fleet. This force is divided into two brigades. The first is stationed at Quantico, Ya., and the second at San Diego, Calif. For purposes of training it operates directly under the Commander-in-Chief, U. S. Fleet and accompanies the fleet on the annual fleet problems. It consti- tutes the force which is ready at all times to go on expeditionary duty. The organization and functions of the medical department of the force on expedi- tionary duty are outlined briefly in the following paragraphs. ORGANIZATION OF MEDICAL DEPARTMENT WITH A MARINE EXPEDI- TIONARY FORCE OF ABOUT THE STRENGTH OF ONE INFANTRY BRIGADE WITH ATTACHED ARTILLERY, ENGINEER, AIR SERVICE, AND OTHER SPECIAL TROOPS The whole medical department is under the control of the force surgeon who is responsible for the sanitation of the occupied area; the collection, evacuation, and hospitalization of all sick and wounded; preparation of reports, records, and returns; procurement, storage, and distribution of medical and surgical stores; training and coordination of all the medical units of the force. For convenience the organization may be shown by briefly considering the various medical units from the front to the rear beginning with that of the infantry regiment (fig. 144). The medical section of an infantry regiment is composed of a regimental surgeon, assistant regimental surgeon, dental officer, and 9 hospital corpsmen. For each of the 3 battalions of the infantry regiment there is a medical section composed of 2 medical officers and 16 hospital corpsmen. The hospital corps- men of each battalion may be assigned duties as company-aid men, litter bearers, or aid-station men. In combat the regimental medical section is concerned with furnishing medical supplies to the battalions, reports and returns, sanitation of the area and coordination of the evacuation of wounded and sick from the regimental area. Regimental aid stations are not established unless the regiment is acting inde- pendently or the military situation requires their participation. The battalion medical section furnishes first aid to and transportation to aid stations for the wounded, and provides for their temporary care until they can be evacuated. With this object in view, aid stations usually are estab- lished behind each battalion. The hospital corpsmen serving as company-aid men go forward with their companies and apply first-aid dressings to the wounded. If the whole force is advancing rapidly, the aid stations are not established until the situation becomes somewhat more stationary, and the wounded who have been given first aid are left in groups to be evacuated by other medical units following. After the company-aid man has completed his initial task of applying first aid, he directs the slightly wounded to the aid stations and the litter bearers transport the nonambulant cases. At the aid stations they are given supplementary first aid, haemorrhage is controlled, shock is combated, pain is relieved, tetanus antitoxin administered, fractures are immobilized with field splints, slightly wounded are treated and returned to their units at the front while those requiring evacuation are sorted, 567 MARINE CORPS EXPEDITIONARY FORCES tagged, and recorded. Wounded able to walk are directed to the collecting station, others are carried thereto by litter bearers from the rear. The aid stations are established as close to the front as the situation permits, taking advantage of any available shelter from rifle and artillery fire, such as dugouts, ravines, and deserted cellars. These places of course should be avoided in the presence of enemy gas. //v/^vr&y jps&M&vr //vwr>p/ /P£6/Af£/Vr /f/PTr/jLeey B/frr/?/./oA/ £A/Ssc j f/y*sec) fAf&tf StPer.) 3n (Zfk \3r>. Y£?J '(£?) Br> 0jey/>A/y |Jyg>/o^r ICb/'/teC’/V/ly /Vos/? ] f /cr^ow/D/y 15gc^'o^> c-«» \S>*e+/or, /Meat J'cypy/y/ /SC ///*»>- 0tJ ( y*fmi>t//crs7cej Jf //Ve>7‘0/> £/£jLO At£& surPL- y £>&&or ££/7C/~f 7~/OA/ ST/9T/OA/ ■sc/00 /tOS/=>/'r^tL Figure 144.—Organization of medical department for one brigade, Fleet Marine Force. As the functions of the battalion-aid station require it to keep close contact with its battalion it must keep as clear of wounded as possible at all times. During combat the battalion-medical section covers the whole area occupied by its organization, from the aid station forward to the battle line. It is essential that all its activities be confined to this area and that its efforts be coordinated by the regimental surgeon, who is informed from time to time by runners or other means of communication from the battalion-aid station, of any change in their location. The battalion surgeon keeps contact with the medical units in his rear by means of a contact agent from the collecting station, who directs the litter bearers forward to the aid station. Routes to aid stations may be shown by some means such as hanging pieces of bandage at intervals 568 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY along the route. Their location should be shown to those in the rear by indi- cating their map position. Dispensary service is established in the regiment when not in combat. The regimental and battalion medical sections are called attached medical troops because each section is part of the headquarters company of its respective organization. jL/A/£T Figure 145.—Schematic distribution of medical department units with a Marine brigade. Fleet Marine Force, in a landing operation. Behind the attached medical troops is the medical company. There are four medical companies attached to each brigade (fig. 145). A medical company consists of a headquarters section, a collecting section, a hos- pital section, and a service section. It is a highly mobile unit whose chief functions are the collection of the wounded and sick from the battalion-aid sta- tions and the further evacuation of these casualties to a hospital ship or evac- uation hospital. Temporary hospitalization is provided as required by the in- dividual case and by the military situation. Secondary functions are the keep- 569 MARINE CORPS EXPEDITIONARY FORCES iug of records and the requisitioning of medical and quartermaster supplies and the distribution of the same. The headquarters section is divided into staff (administration, personnel, and records) and medical supply (materiel and storeroom). The service section consists of mechanics, electricians, cooks, supply and commissary personnel, and drivers for the ambulances and trucks of the company. Storage, lighting, and water trailers complete the rolling equipment of the company. The medical company forms the relay for evacuation of all wounded and sick from front to rear by establishing collecting stations, ambulance stations, hospital stations, and beach-evacuation stations. In combat the collecting-section group establishes a collecting station at a point giving protection from enemy fire, which should be as near to the bat- talion-aid stations as possible. This station should be equipped with surgical dressings in abundance, medicines, hot food, and water for the wounded. Its functions are to sort the wounded, reapply dressings if necessary, and prevent shock. When the collecting station is established the litter bearers of the collection section bring in the wounded from the battalion-aid stations; ambulances are used when possible. The collecting section also establishes the ambulance station ordinarily about midway between the collecting station and the hospital station. It is merely a control point, which, when established, sends forward one or two ambulances to carry the nonwalking wounded from the collecting station to the hospital station, and then returns to the ambulance station. When loaded ambulances pass the ambulance station on their way to the rear, others from this control center are sent forward by the regulating officer to replace them. Treatment of the wounded ordinarily is not attempted between the collecting station and the hospital station. The service section establishes and maintains the medical company mess; req- uisitions, cares for, and issues quartermaster supplies; and provides chauffeurs, cooks, and mechanics. On the march, when not in the presence of an enemy, collecting stations are established along the route to provide temporary shelter for men falling out from illness or injury. These stations are evacuated by the ambulances follow- ing the troops and the casualties are carried to the camp-hospital station. The hospital section is a relatively lightly equipped hospital, capable of free movement in the field, and establishes a hospital station to the rear of the am- bulance station, thus forming a relay in the evacuation system from front to rear. In combat, this section establishes a hospital station where all sick, injured, or wounded cases are received and properly cared for. Surgical operations are performed when necessary, but the hospital section must at all times, to be fully effective, be capable of evacuating all wounded, so that the organization can advance as an active part of the field force. This would be done, when the distance is not prreat, by evacuating to a hospital ship or a base hospital. When a unit of a medical company which has established a hospital station fills up, another company establishes a new station and the first takes no more cases, but clears itself and then stands by to form a new hospital station. Thus dur- ing an advance the hospital sections would “leapfrog” each other. This completes a brief outline of the mobile portion of the medical department of an expeditionary force. Under certain circumstances, however, if the dis- tance between the hospital station and the base becomes too great, as in an advance, another medical unit must provide hospital treatment in order that the hospital section may remain mobile. This service is performed by the 570 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY evacuation hospital, which is organized with headquarters and various sub- divisions similar to those of a naval hospital. As its equipment is relatively elaborate, it moves only with the aid of a large number of trucks or by rail. It is intended to give the complete or definitive treatment ordinarily given by the hospital ship or base hospital, and is used only under the condition men- tioned. The field medical supply depot on the hospital ship or with the expedition quartermaster carries sufficient medical and surgical stores for resupply for a given period. This relatively frequent resupply is necessary in order that the supply section of the medical company may remain mobile. This depot also carries more elaborate dispensary equipment for attached medical troops and hospital equipment for the medical company, which they may be able to use to advantage under certain conditions, as during the occupation of an enemy city, in a semipermanent camp, or in a defensive position from which no advance is intended. Section 8.—LANDING FORCE Hospital corpsmen serving on board combatant ships must also be prepared to serve ashore as members of the medical department of the ship’s landing force. Organization and equipment. A permanently organized landing force consisting of infantry, artillery, machine guns, and other auxiliary units, is maintained on each ship and is known as the ship’s battalion. It varies in size and composition according to the type of ship. For a ship of the first rate it normally consists of one com- pany of Marines, two companies of Navy infantry, and one company of Navy artillery, a machine-gun unit, the battalion commander and staff, and special details consisting of pioneers, signalmen, cooks, messmen, and the ambulance party. This organization is flexible, so that all or any part may be landed at the discretion of the senior officer present. The ambulance party which is commanded by the battalion surgeon, usually the junior medical officer of the ship, is ordinarily composed of two litter bearers from the line of each company, or preferably, an equal number from the ship’s engineering divisions, with a chief pharmacist’s mate and as many hospital corpsmen of the lower ratings as the circumstances may demand. The total number of litter bearers should not be less than 2 per cent of the number of combatants landed. During an actual engagement, in order to reduce the number of ineffectives to a minimum, messmen, orderlies, and others not actually engaged in their own legitimate duties, should he pressed into service to augment and reinforce the litter bearers. This additional personnel should recover the arms and ammunition of disabled men, assist in the transportation of the wounded, and perform such other duties as the battalion surgeon may direct. Litter bearers should invariably be drawn from line personnel. In an actual engagement, hospital corpsmen will be so busily engaged in the dressing of wounds and in other professional work, that it will not only be impractical but will also be disastrous to even attempt to employ them in any other capacity. The assignment of hospital corpsmen as litter bearers will weaken the entire medical organization, destroy its morale and ruin its effi- ciency. The equipment of the ambulance party depends largely upon the nature of the battalion’s duty ashore. Ordinarily the litter bearers and hospital corps- LANDING FORCE 571 men carry no weapons, but wear the Geneva Cross on the left arm; however against a savage or uncivilized enemy, the personnel of the ambulance company carry pistols and omit the brassard. The battalion may be assembled for landing either fully or lightly equipped. When fully equipped each member of the ambulance party wears the uniform prescribed and carries a pack carrier (packed), haversack, rubber blanket (poncho), cartridge belt, filled canteen and wears leggings. There is no pro- vision for carrying the overcoat on the pack. When weather conditions make it necessary to carry the overcoat it has to be worn. The haversack contains rations, knife, fork, spoon, meat can, bacon can, and condiment can; also a towel, soap, comb, toothbrush, tooth powder or paste, sewing kit, matches and tobacco and pipe, if desired. The poncho is folded to suitable size and carried in the haversack on top of the rations. The pack carrier when completely assembled should contain one-half of a shelter tent with the accompanying tent pins and pole, a blanket, one pair of trousers and one jumper, one pair of drawers and one undershirt, two pairs of socks, a white hat, and a comfortable pair of high shoes. When pack carriers are not provided, the most necessary of the above mentioned articles are carried in the blanket neatly rolled length- wise, covered with the poncho and stopped with clothes stops, and the roll placed over the left shoulder with both ends of the roll secured together under the right arm. When the battalion is lightly equipped the men carry filled canteens and cartridge belt and wear leggings. The blanket and poncho or the pack carrier with haversack may be prescribed if circumstances require it. The special equipment of the ambulance party is as follows: (a) One litter for each two bearers. (5) A Geneva-cross brassard for each man. (c) A Hospital Corps pouch for each hospital corpsman. (Large for chief pharmacist’s mate; small for others). (d) A Geneva-cross flag on a staff. The expeditionary medical and surgical units and the medical emergency boat boxes are available for use with the landing force. Preparations are made by the battalion surgeon for an additional supply of instruments, dressings, and other equipment for an expedition in accord- ance with the length and character of the service and he will invariably make an inspection of all equipment prior to embarkation to see that medicines, instruments, dressings, and the men’s clothing are ample and in proper condi- tion. Each member of the ambulance party should wear his identification tag attached to the neck. The mission of medical-department personnel in a landing force. The mission of the ambulance party is to keep as many men physically fit as possible; to give prompt and efficient treatment to wounded or inca- pacitated personnel; to provide for rapid evacuation of casualties and to maintain and promote the morale of fighting units. Before leaving the ship, all personnel participating in the landing, should be subjected to a careful examination for the purpose of eliminating the physically unfit. If this is not done, there will be many men engaging in the landing who will not be able to keep up with their respective units, they will easily become fatigued and rapidly exhausted and therefore will be a distinct detriment to the efficiency and morale of the fighting force. Mobility is of vital importance to a landing force and the successful accomplishment of the mission assigned cannot be 154294°—39 37 572 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVF gained without it. When the order is given to man the boats, 1)61800061 should leave the ship via cargo nets that have previously been secured along the hull of the vessel and not via gangways. The cargo net method of loading men into small boats is a much safer method and a much mtore rapid and effective procedure than the use of the gangway; this is especially true in rough weather. Medical-department personnel of the landing force should be divided into sections and accompany their respective line units; their medical equipment goes along with them. This division of personnel and equipment prevents total loss, in case an individual boat in which all personnel and supplies is being carried, is sunk. The medical equipment for a landing force is arranged in packs and is easily carried on the backs of hospital corpsmen. These packs when filled to capacity have a maximum weight of only 35 pounds and are waterproof for 10 minutes submergence. This method of carrying medical material greatly facilitates the embarkation from small boats and renders it a far less dangerous procedure than with the employment of the old and cumbersome medical and surgical chests. Re- ducing the weight and the bulk of medical materiel that personnel must carry is of vital importance, for hospital corpsmen must keep up with their respec- tive units in the field, therefore anything that unduly reduces mobility de- tracts from efficiency. On landing, the ship’s battalion may join battalions from other ships to form a regiment, which in turn may be associated with other regiments to form a brigade. Both the regiment and brigade have a medical organization which is outlined in the Manual of the Medical Department, United States Navy. Ordinarily the ambulance party of each battalion will operate with that battalion. In an actual engagement, the important duties that medical- department personnel will be called upon to perform will fall under the following captions: 1. Relief of pain (morphine). 2. Arrest of haemorrhage (tourniquets and compression). 3. Control of shock (artificial heat; morphine; absolute rest). 4. Immobilization of fractures (splints, often improvised. “Splint ’em where they lie”). 5. Treatment of wounds: (a) Haemostasis. (b) Asepsis. (c) Suturing. (d) Sterile dressings. (e) Bandages and adhesive plaster. (f) Tetanus antitoxin or combined with gas-gangrene antitoxin. 6. Evacuation (stretchers and motor transportation). The medical-department personnel of the landing force, including company- aid men, battalion-aid station tmits, and collecting and ambulance sections, treat, collect, and transport wounded or incapacitated personnel from the front line to the beach. Here the responsibility of the landing force medical- department personnel ceases. The problem of transporting the wounded from the beach to the ships of the fleet rests upon the medical units afloat. In the event that the tactical situation demands the holding of ground gained, it may be necessary for a landing force to establish a temporary camp. In the event of such a contingency it becomes the duty of medical-department personnel to plan and advise in regard to necessary sanitary measures. It is a well-established fact that failure to observe essential and fundamental princi- LANDING FORCE 573 pies in hygiene and sanitation brings upon the personnel engaged in field opera- tions against an enemy greater misery and more deaths than all the bullets and machinations of the enemy. In any landing expedition the tactical situation will undoubtedly determine the location of the camp. In any camp, wherever it may be, three important sanitary problems concerning water, food, and the disposal of wastes must be settled. Water from questionable sources or of doubtful purity must not under any circumstances be employed for drinking purposes. In the event that it becomes necessary to use water, the source of which is questionable, it must in all cases be subjected to chemical or physical methods of purification before being em- ployed for drinking purposes. Boiling is the best method of rendering question- able water safe for drinking. In the event that this method is impracticable, chemical methods of purification must be used. The chemical compound that is usually employed for this purpose is calcium hypochlorite. (See p. 530.) The food supply in a camp of this type is likely to be inadequate in quanti- ty and of doubtful quality. As a precautionary measure against food infections an order should be promulgated and enforced to the effect that no food will be served unless it has been thoroughly and recently cooked. The disposal of wastes and camp sanitation is fully discussed in the section on Field Sanitation. Latrines should be placed to the leeward, 100 yards from the galley and mess halls and at least 75 feet from the nearest tent. In the event that the encamp- ment is to be for a period greater than 1 week, the disposal of human excreta will be via the pit type of latrine and all latrines will be thoroughly and effi- ciently flyproofed. The fly menace should be combated by eliminating breeding places and destroying adult flies; by protecting all food intended for human consumption from flies; and by the disposal of human excreta in such a manner that flies cannot gain access to it. In an encampment of this type, a sickbay will be established where all in- juries and diseases will be treated as efficiently as the facilities available will permit. A record of all patients treated must be made. All cases of sufficient importance to warrant admission to the sick list will be written up on loose leaves from health records and a Form F card prepared when the case is discharged to duty or otherwise disposed of. A journal also is kept in which daily entries of all important, interesting, and pertinent data pertaining to personnel, hygiene, and sanitation are recorded. Upon return to the ship the medical entries are to be inserted in the proper health records. Drills, inspections, and parades. Frequently at sea or in port, the ship’s battalion is formed for Inspection or drill. The ambulance party assembles at a place on deck designated in the ship’s organization scheme. Members of the party should report promptly in clean uniform and with the equipment specified. The party is mustered by the chief pharmacist’s mate, who reports the result of the muster to the battalion surgeon, who in turn makes a report to the battalion adjutant. When the battalion surgeon is away from the ambulance party’s place of assembly, the party is in charge of the chief pharmacist’s mate, who should see that the men keep in formation, and refrain from loud talking or other disorder. If the battalion is formed for inspection of the equipment, the pack carriers are unstrapped, the packs removed, unrolled and arranged as explained in the Hospital Corps Drill Book. The ship’s battalion sometimes is landed for parades or reviews. On these occasions the ambulance party follows the battalion, each litter being carried 574 HANDBOOK OF THE HOSPITAL CORPS, U, S. NAVY by four bearers, the litters being horizontal and carried abreast of each other. It is landed not simply for parade, but to administer first-aid treatment in cases of sunstroke, accident, or sickness. References Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. Section 9.—SHORE PATROL Whenever a fleet or vessels of the United States Navy visit a United States or foreign port it is! customary to land a body of men known as the shore patrol. The purpose of this patrol is to preserve order among the men who are ashore on liberty and to enforce whatever regulations concerning the port the senior officer present may issue. A medical officer and some hospital corpsmen usually are detailed for duty with the shore patrol and become an integral part of it. The duty of the medical detachment of a shore patrol is to render emergency medical and surgical treatment to men ashore on liberty from the vessels present and to members of the shore patrol who may be injured or become ill. The ease with which this duty may be performed depends greatly upon the nature of the port in which liberty is granted. In a well-organized com- munity possessing an efficient police force, public hospitals, and ample facilities for handling large liberty parties, such as are found in any well-organized municipality, the problem is easy to solve. But in cities having few attrac- tions for the men, no welfare activities, numerous liquor stores, houses of prostitution, and an inefficient police force the problem presents a different aspect. It is a port of this type which will be considered in this section. The personnel of the medical detachment of the shore patrol should consist of one medical officer and four well-trained, reliable pharmacist’s mates. Each man should carry ashore with him his field equipment, viz., a poncho, belt and canteen, extra shoes and leggings, a change of underwear and socks, an extra suit of whites or blues, hammock, mattress, cot, two blankets, mosquito net, necessary toilet articles, two towels, shoeblacking, a notebook, and pencil or fountain pen. The detachment should have a bucket for water, a washbasin, and a supply of toilet paper. In many ports the members of the shore patrol will be quartered in a hotel, or in a comfortable military barracks or in a police station, but one never knows what is ahead ofs him when liberty is given in a strange port, so each pharmacist’s mate detailed with the shore patrol should go ashore prepared to camp out in whatever quarters are available. He may find himself lodged in an empty warehouse or in the baggage room of a x’ailway station. Before leaving the, ship it is necessary to assemble certain material for use in connection with the treatment of sick or Injured among the liberty party. As conditions ashore are more or less unknown a fairly complete field equip- ment will be necessary, in which must be the following: 1. A Geneva-cross flag and staff to mark the main dressing station. 2. The medical and surgical expeditionary cases. 3. A mess table upon which to place the expeditionary cases and other appli- ances at the main dressing station. 4. Three folding cots. 5. Three pillows with pillow cases. SHORE PATROL 575 6. Three blankets. 7. Two Stokes’ splint stretchers, each having a pillow and two blankets. It is advisable to place a tag bearing the name of the ship on each of these stretchers and on each blanket as they may be used for the transportation of men to the hospital ship and easily become lost unless tagged. 8. Two buckets for water. 9. Four washbasins (two for main dressing station and two for venereal prophylactic station). 10. Five hundred cc of Tincture of Iodine, or Tincture of Merthiolate. 11. An ample supply of sterile dressings and bandages. Materials to make tincture of iodine and compressed dressing material are to be found in the expeditionary cases, but it is better to use a freshly sterilized supply of dress- ings' and to disturb the cases as little as possible as it might be impossible to renew supplies from them for some time. 12. A blank book to be used for a journal in which is to be entered an account of all the detachment’s activities, especially notes of all cases treated and examinations made. 18. A package of shipping tags. 14. Material for venereal prophylaxis and report blanks which when tilled out are sent to the medical officer of the applicant’s ship. The quarters for the shore patrol generally are selected by an officer of the Train, Base Force, which usually arrives in advance of the fleet. Therefore when the patrol party lands, it is marched at once with its equipment to the quarters selected. It is a good rule in Navy life never to become separated from one’s bag- gage, so on this march from the dock to the quarters see that all the medical- department equipment is brought along and none left on the dock. Most of the material brought ashore can be packed in the two splint stretchers and carried safely with the aid of meu from the patrol, who will be detailed by the senior patrol officer on request. Having arrived at the patrol quarters, the sleeping accommodations for the pharmacist’s mates are arranged for. These probably will be with the rest of the patrol, and the comfort each man gets depends upon his adaptability for service in the field. Next comes the question of food. In some ports the shore patrol will be subsisted from some vessel and the cooked food sent ashore. Usually, however, each man’s ration is commuted and he is allowed not more than 75 cents for each meal. A survey of the neighborhood will reveal the best eating places. Remember that no member of a shore patrol is permitted to drink any alcoholic beverage while on duty. The next step is to establish the main dressing station, where seriously injured men may be brought for first-aid treatment. This station should be as near the landing place as possible and should be marked by the Geneva- cross flag. Having secured a suitable location, set up the three cots and the mess table, upon which place the expeditionary cases and two of the wash- basins, together with other dressing material. This table will be found very useful as a dressing stand. Secure a supply of fresh water and make up whatever antiseptic hand solution the medical officer uses, covering it with a clean towel. The splint stretchers should be prepared for use and placed out of the way. One pharmacist’s mate is detailed to care for the main dressing station. The venereal prophylactic station likewise should be established near the landing place and if possible adjacent to the main dressing station. Experi- ence has shown that these two stations should not be combined, because if there is opportunity for much exposure to venereal disease in the port it is 576 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY likely that a large crowd of noisy men will visit the prophylactic station and if the dressing station be in the same place its proper functioning will be interfered with. This station must be in charge of one pharmacist’s mate, who will prepare and supervise the treatment and fill out the treatment report blanks. He should be assisted by at least two members of the shore patrol, whose duty is to preserve order. The prevention of venereal disease is most important and must be faithfully and conscientiously carried out. It is not agreeable duty, as the patients often are under the influence of liquor, foul- mouthed, and disorderly, but if venereal disease is prevented by the treatment it is worth all the effort expended. A dressing station equipped with a Hospital Corps pouch and a supply of sterile dressings, iodine, and bandages, and in charge of one pharmacist’s mate, should he established at the landing place, as it is to be expected that many men will present themselves with minor wounds which require steriliz- ing and dressing before embarking for their ships. All cases of serious Injury, such as fractures, severe haemorrhage, large lacerated wounds, etc., appearing at this station should be sent to the main dressing station for treatment be- cause at the landing there will be more or less confusion caused by embarking men, some of whom may be intoxicated. At the landing place a space should be reserved for the reception of severely intoxicated men. This space should be so located as to safeguard the men placed in it. Many of these men will be unconscious or semiconscious, others will be noisy or talkative, while others will be fighting drunk. If these men be permitted to wander about at will there is danger of their falling off the dock into the water or onto the landing float. The space selected for tihe retention of drunken men should be in charge of a competent chief petty officer of the shore patrol. He should have sufficient assistants to preserve order. The fourth pharmacist’s mate should act as a relief for meals and as assistant to the medical officer. Experience has shown that none of the stations men- tioned should be left unmanned while the liberty party is ashore. One never knows when a serious accident will happen. A man may be run over by a trolley ear or shot or stabbed at any time. Liberty in a port such as is being discussed generally begins at noon and expires at 8 p. m., but it will probably be midnight before the dock is cleared of the last stragglers; and until all the liberty party has embarked the medical detachment must keep their dressing stations open because the patrol in their final search of the streets for the night may find some men injured or unconscious. As soon as possible after the landing the medical officer of the shore patrol should make a sanitary survey of the port. This survey should include an investigation of the food and water supply of the port, the diseases prevalent, and the neighborhoods harboring contagious diseases or houses of prostitution. With the information so gained, and through the cooperation of the senior patrol officer he should prevent, as much as possible, the exposure of the liberty party to disease by suitable recommendation for the restriction of infected localities. There are several special points relating to the activities of the medical department which are well to bear in mind. Frequently men are brought down to the landing place profoundly intoxicated and often unconscious. Each of them should be examined carefully by the medical officer, as the uncon- sciousness may be due to a head injury which necessitates immediate trans- portation to the hospital ship. An attempt should he made to identify every unconscious man. Examination often will show that he has no identification tag and his clothing may bear several names; therefore it becomes necessary 577 SHORE PATROL to learn, his name and the name of his ship from his shipmates who may be around. Write this information on a shipping tag and tie it securely to his clothing, then have him placed in the space reserved for intoxicated men. This will facilitate his return to his ship. Men will be brought to the medical officer for examination to determine whether they are under the influence of liquor. If the man is found under the influence of liquor, careful notes should be made in a notebook kept for this purpose of all the details of the case—the man’s name, his rating, his ship, his peculiarities, or marks by which he may be identified, and the signs or symptoms upon which the decision that he is intoxicated is made. Then get some officer or chief petty officer from his ship to identify him and record that officer’s name for future reference. All this is necessary, because men often give wrong names and have no identification tag or proper marks upon their clothing, and the medical officer in all proba- bility will be called as a witness by a court-martial in the case weeks after, and unless he has kept a very clear record of each case and has the identity of each man pronounced under the influence of liquor clearly in mind he will not be able to give clear testimony in court. Men seriously injured may be expected at the main dressing station at any time, and provisions for their care always must be in readiness. Great care must be taken to identify each badly injured man and to place upon him a tag bearing his name, rating, and the name of his ship. All severely injured men after having been given the necessary first-aid treatment should be sent im- mediately to the hospital ship, where there are medical officers always on duty. If an injured man should be sent to his own ship, it is possible that the medical officers of that vessel might be ashore and the professional attention required would be lacking. Severely injured men are best transported in the splint stretcher, and may be sent to the hospital ship in either a patrol boat or a liberty boat, which may be diverted from its regular duty by order of the senior patrol officer. When an injured man is sent to the hospital ship a member of the medical detachment should accompany him to care for him enroute and to insure the prompt return of the stretcher to the dressing station. In every case involving an injury ashore of sufficient importance to require treatment and the return of the individual to his ship, or of sufficient severity to demand direct transfer to the hospital ship or hospital ashore, an immediate report will be submitted to the senior medical officer of the ship to which the man is attached, giving answers to the following questions: 1. Was the man on authorized liberty? 2. Was the man intoxicated? 3. Was the injury due to his own misconduct? 4. Concise and pertinent facts concerning the circumstances attending the injury. The information given under No. 4 should be so explicit that anyone with no previous knowledge of the case may read it and visualize the accident. This report must invariably be sent to the senior medical officer of the ship to which the individual is attached whether or not the man is returned there. In the event that the injured patient is transferred direct to the hospital ship or a hospital ashore a duplicate of the report should be submitted to the activity concerned. In addition, a file copy for future reference should be retained. This procedure is of the utmost importance but unfortunately is often neglected. The importance of this report is undoubtedly realized and apprec- iated by everyone in the medical department of the U. S. Navy. Injured per- sonnel are constantly being sent to the hospital ship with no information as 578 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY to the circumstances attending the injury, or if information is submitted it is often insufficient, inaccurate, misleading, and therefore of no value. Upon re- ceipt of such a case the senior medical officer of the hospital ship immediately sends a radio to the medical officer of the ship to which the man is officially attached requesting information at once; however this unfortunate medical officer has no more and probably less information than the hospital-ship author- ities. So in the end a medical officer must go ashore and spend the major part of a day obtaining information that the patrol officer could have easily secured at the time the accident occurred, thus saving much inconvenience, time, labor, and expense. References Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. CHAPTER VII DIETS AND MESSING FOR THE SICK Feeding the sick has become so important a factor in their treatment and cure that it may well be termed Diet Therapy and placed among the other reme- dial agents employed in therapeutics. While not actually a remedy in itself, diet therapy supplements and makes other treatment more effective. Where formerly the feeding of the sick was based largely on experience and observa- tion and the patient’s whims and fancies as well as his physical disability, today, because of the marked increase in the scientific knowledge of the composition of foodstuffs, of their metabolism in the body, and of their relation to normal and pathological conditions in the body, it is a science. Due to variable factors such as age, temperament, idiosyncrasy, etc., influencing metabolism, it cannot be classed as an exact science and consequently diets for the sick require more or less individual prescription. In common with all sciences, dietetics requires a knowledge of the other sciences with which it is allied. Nutrition is the process of providing the body with the necessary material for maintenance, growth, and renewal of all the body tissues. Dietetics is the science which treats of food and its effect on the body in health and disease. Foods are those substances obtained from the animal, vegetable, and mineral kingdoms which, when taken into the body, yield heat and energy, build and renew tissues, and regulate the body processes and internal conditions. They usually are classified as proteins, carbohydrates, and fats, and equally essential for life are water, inorganic mineral salts, and vitamins. Foods contain other substances which, while not absolutely necessary, are useful in nutrition through increasing or improving the palatability of food and stimulating the flow of digestive juices. These substances are known as accessory articles of diet and consist of: Flavors, various substances that give odor and taste to foods; condiments, as pepper, salt, mustard, etc., and stimulants, as alcohol, tea, coffee, cocoa, etc. Proteins, the only class of foods containing nitrogen, sulfur, and phosphorus as well as carbon, hydrogen, and oxygen, are found in both the animal and vegetable kingdoms. All proteins are built up of amino acids, the proportions of which differ widely in proteins obtained from different sources. Some of these amino acids are absolutely essential for the maintenance of life while others are necessary for the growth and development of the body. The difference in proportions of amino acids determines the biological (or nutritive) value of proteins and according to their amino-acid content proteins are knowui as “complete,” as those found in lean meat, milk, and eggs, “partially complete,” of which type those in cereals and legumes are examples, and “incomplete,” as gelatin. Proteins are essential in food to promote growth and renew tissue. They also yield energy but are an expensive source of it. Deficiency of protein in the diet will stunt growth, promote a secondary anaemia or induce nutritional cedema. The amount of protein necessary in the daily diet is a disputed point. Experiments have shown a minimum of 0.6 Gm. per kilogram of body 580 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY weight to be necessary. An optimal amount is from 1.0 to 1.5 Gm. per kilogram of body weight, or 70 to 100 Gm. a day for a man weighing 70 kilograms. Part of this protein should be of good biological value, as protein from animal sources. Carbohydrates, containing carbon, hydrogen, and oxygen, are found largely in the vegetable kingdom, are easily procured and inexpensive, and usually rep- resent from 50 to 75 per cent of the normal diet Examples are sugars, syrups, grains, vegetables, and fruits. They are also found in milk, and are the most valuable source of energy. They are protein sparers in the body if for any reason proteins must be curtailed. They may be stored in the liver as glycogen to be used by the body when needed, and when taken in excess are stored as adipose tissue. When taken too sparingly, weight is lost and acidosis may result. Carbohydrates are essential for the metabolism of fats. In the form of glucose, carbohydrates are the most valuable emergency fuel for the body. Pats, like carbohydrates, contain carbon, hydrogen, and oxygen, but in dif- ferent proportions and are found in both animals and vegetables. Examples are butter, cream, cheese, fat meats, egg yolks, nuts, and vegetable oils. They are the most concentrated source of energy, are protein sparers, and are essential for all cells. Fat acts as a padding both for organs and subcutaneous tissue and is stored up as adipose tissue to form a reserve supply in time of need. The fat requirement varies with the individual, and also depends on his protein and carbohydrate intake. In the normal diet fats usually make up from 35 to 50 per cent of its calories. An excess of fat in the diet is apt to promote indigestion. It is bound to produce obesity, the forerunner amongst the middle-aged of arteriosclerosis, hypertension, diseased gall bladder and diabetes. Water, composed of hydrogen and oxygen, makes up two thirds of the body weight and is found in every cell in the body. It is the most important single item in the diet, and is found in all beverages and in all foods not artificially dehydrated. Six to eight glasses of water a day is a normal intake. Taken in excess water may overtax a diseased heart and kidneys, while an insufficient intake causes constipation, loss of weight, disturbs the maintenance of normal body temperature, and causes dehydration inducive to ketosis. The inorganic mineral salts found in the body are calcium, phosphorus, magnesium, potassium, iron, sodium, chlorine, iodine, copper, and others in small amounts. The more important ones will be discussed briefly. Calcium. Good sources of calcium are milk, cheese, egg yolk, dried beans, almonds, peanuts, walnuts, turnips, oranges, and dried prunes. Most of the calcium in the body is found in the bones and teeth, but is by no means limited to this use. It is essential for the coagulation of blood, for normal heart action, and for contractility of the muscles. Deficiency of calcium in the diet, and this is the most common deficiency in the American diet, causes faulty structural development, rickets, dental caries, heart atony, tetany, and excessive bleeding. The amount of calcium needed in the daily diet is 0.68 Gm. for an adult. This is increased to 1.0 Gm. a day for a child. One pint of milk a day will keep an adult in positive calcium balance while 1 quart of milk is necessary for a child. Phosphorus is found in cheese, eggs, whole grain cereals, meat, dried beans and dried prunes in good amounts. Two-thirds of the phosphorus In the body is found in the bones and teeth. It is also found in every cell in the body and thus is essential for growth. If the phosphorus intake is not suf- ficient, the results are poorly developed bones and teeth, retarded growth, and rickets. An adult needs 1.32 to 1.5 Gm. of phosphorus a day, and the growing child needs more. DIETS AND MESSING 581 Iron. Good sources of iron are liver, kidney, heart, beef, egg yolk, oatmeal, dandelions, almonds, apricots, peaches, green vegetables, and dried fruits. It is essential for the formation of haemoglobin and lack of it in the diet causes anaemia. Fifteen milligrams of iron daily is necessary in the diet of an adult. This amount is increased in the diet of a child and in nutritional anaemias. Copper has been found in recent years to be absolutely essential for the utiliza- tion of iron in the body. Although the daily requirement is very small, 0.0002 Gm., anaemia will develop without it. Copper is found in liver, bran, sea- foods, nuts, leafy foods, and legumes. Iodine is found in fish and vegetables of nougoiterous regions. It is essential for the normal functioning of the thyroid gland and lack of a sufficient amount will cause goiter. The amount needed daily is not known but different goiter belts prescribe from 15 micrograms for an adult to 150 micrograms for a child. As the iodine content of the foods and drinking water in these regions is so variable, or lacking entirely, iodine is introduced in the drinking water or table salt and is sometimes given in weekly doses in the schools. A microgram is one millionth of a gram. Vitamins are substances which are absolutely necessary for the maintenance of health and were once called “food factors of unknown natures.” Later they were thought to be amines necessary for life and were given the name of “vitamines.” Many years of scientific investigation has proved their existence and that they are essential to health beyond the possibility of doubt. They now are known as “vitamins” (the letter “e” having been dropped from the spelling of the word) which is considered to signify only that they are essential to life. It is an unsatisfactory name but a better one has not yet been chosen. Their chemical composition is gradually becoming known, pure preparations of most of them have been made from natural sources, some have been prepared artificially in the laboratory, and much has been learned about the part they piay in life and health. The existence of 6 vitamins has been established, more are recognized, the existence of others is suspected, and some now considered to be single vitamins may be found to consist of 2 or more. An antihsemorrhagic dietary factor, to be known as vitamin K, has been discovered and appears to be concerned with the regulating of the time required for blood to clot. Vitamins are designated by letters of the alphabet in the order of their discovery, except vitamin B which was discovered shortly before vitamin A. Vitamin A is called “fat soluble” because it is soluble in fats. Very little of it is destroyed by ordinary cooking as it is only slightly soluble in water and is very little affected by heat. It is destroyed by drying. Taken in excess it can be stored in the liver. Sources of vitamin A are fish-liver oils, liver, fish roe, egg yolk, milk, butter, cheese, escarole, lettuce, carrots, sweet potatoes, apricots, and peaches. Vitamin A stimulates growth and development, and is necessary for well- being at all ages. It has a definite part in the maintenance of the normal protective function of the mucous membranes lining the nasal passages, the mouth, the throat, the intestinal tract and various other body cavities. A long-continued deficiency results in arrested growth, defective tooth and bone formation, nutritional night blindness, and loss of reproductive power. Defi- ciency also causes xerophthalmia, a condition of the eyes and lacrimal glands which may result in total blindness. Vitamin A itself occurs only in animal and sea foods but plant foods having a deep yellow or green color contain certain pigments which are changed into vitamin A in the body, and are known as provitamin A. 582 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The daily requirement of vitamin A for an adult is 5,000 to 6,000 Interna- tional units. One quart of milk will furnish about 1,000 International units of vitamin A and 1 Gm. of calcium. Vitamin B is now known as “vitamin B complex” for the reason that scientific investigation has shown it to be a complex dietary factor instead of a simple one as was at first believed. The existence of 5, and possibly 6, factors having distinct and separate biological properties has been determined, which, for convenience, have been designated as vitamins Bi, B2, B3, B4, B0, and B8. In the United States vitamin B2 is also known as vitamin G. Vitamin Bi, or thiamin, and sometimes called aneurin, is known as the amtineuritic vitamin, is soluble in water, and destroyed by heat. Some of it is lost in improper cooking, by refining, and by the addition of alkalis. Being water soluble much of the vitamin Bi contained in fruits and vegetables may be in the water in which they are cooked, and it is therefore advisable to use as little water as possible in cooking them and to serve the cooking liquor with the foods. The liquor with canned fruits and vegetables should also be used. It is found in small amounts in many foods, good sources being whole- grain cereals and breads, yeast, dried beans, broccoli, and other green veg- etables, chicken, brains, liver, kidney, and lean pork. It is also manufactured commercially. Vitamin Bi is necessary for the normal functioning of the nervous system and for normal muscle tone of the alimentary tract, and it is believed general health and well being could be much improved if more of it was contained in the daily diet. It is also necessary for the normal oxidation of sugars in the body. A deficiency stops growth and causes loss of appetite, a sluggish digestive system, and nervous irritability. Absolute lack of vitamin Bt pro- duces the disorder of the nervous system known as beriberi. Vitamin Bi does not stimulate normal appetite as is sometimes claimed. The daily requirement for this vitamin is believed to be about 400 to 500 International units. Vitamin C, or ascorbic acid, and also known as cevitamic acid, is the anti- scorbutic vitamin, is water soluble, and is destroyed in cooking (when air is present) as well as in the presence of alkalis. It can be stored in the body in a limited degree and is found largely in the vegetable kingdom. It is present also in the suprarenal glands. Excellent sources are green vegetables, peppers, turnips, horseradish, most fruits, sprouted seeds, liver, and brain. Citrus fruits and tomatoes are especially rich in this vitamin. Raw fruits and vegetables are preferable for supplying this vitamin although canned fruits and vegetables are good sources as, in most cases, air is ex- cluded during the cooking process. Vitamin G is essential for growth and good health. It is particularly im- portant for normal capillary blood vessels, good teeth, and healthy gums. Bleeding gums, loose teeth, sore joints, loss of appetite with loss of weight and fatigue, are symptoms of a lack of vitamin C and of the disease known as scurvy. An adequate allowance of vitamin C for the adult is 1,200 to 1,500 Inter- national units which can be supplied by one large orange or one-half a grapefruit. Vitamin D, the antirachitic vitamin, is fat soluble and is not destroyed by ordinary cooking. It is not widely distributed in foods being found naturally in only a few in important quantities. Foods containing certain substances known as provitamin D when exposed to ultra-violet rays become sourced of vitamin D into which the provitamin D is changed. Ergosterol, a complex 583 DIETS AND MESSING substance resembling fat or oil but not saponifiable, and widely distributed in plant and animal tissues, of which the skin is one, is changed into vitamin D on exposure to ultra-violet rays. This vitamin is necessary for the utilization of calcium and phosphorus in the body and is therefore essential for the formation of bones and teeth. A lack of it retards growth, especially of bones and teeth, and an excessive deficiency results in rickets, a disease that until recently afflicted in some degree nearly 80 per cent of the children in large cities in America and western Europe. The daily requirement of vitamin D for adults is not known but 400 to 600 International units provide for good growth and maximum calcification in infants. Overdoses of this vitamin are toxic. Egg yolk, fish-liver oils, salmon, sardines, and dairy products are good sources of this vitamin, as are foods enriched by irradiation. The concentrates, as fish-liver oils, are advised for use in the winter months, especially for children. Vitamin E, the antisterility vitamin, is fat soluble and heat stable, and is essential for reproduction. It is found in small quantities in many foods, the germ of the wheat grain being an especially rich source. It is not deficient in the human diet as it is present in green lettuce, vegetable oils, and a number of other vegetables in considerable quantities. Vitamin G, or riboflavin, is also known as vitamin B2. It is a yellow pigment widely distributed in both animal and plant foods, is water soluble, and is not easily destroyed in cooking except in the presence of alkalis. The best sources of this vitamin are lean meat and glandular organs, eggs, milk, and green vege- tables, and it is also found in the germ portion of wheat, in peanuts, soybeans, and rice polishings. The use of vitamin G in the body is not yet clear but it is believed to play a part in the chemical processes of all living cells and it has been stated that it increases nutritional well-being. Experiments on animals have shown that a deficiency results in retarded growth, loss of hair, and nutritional cataract. No figures are yet available for the amount needed daily but protection is sup- posed to be afforded by 1 pint of milk, 1 serving of turnip greens, 1 serving of grapefruit, 5 slices of whole-wheat bread, or 1 egg. The P-P (pellagra-preventing) factor, or nicotinic acid, was identified in 1937. An insufficient amount of this factor in the diet appears to be the chief cause of pellagra, a disease common in the southern part of the United States and to alcoholics. It is found in liver, lean meat, salmon, egg yolk, butter- milk, collards, green peas, turnip and other greens, and tomato juice. Deficiency of this factor first is followed by loss of appetite, loss of weight, and general weakness. If the deficiency is prolonged sore mouth, digestive and nervous disturbances, and eruptions on the skin of the hands, arms, feet, and legs result. This factor is still in process of study and no figures are yet available as to the daily requirement. It is known that 1 to 2 milligrams daily will cure pellagra. ENERGY VALUE OF FOOD AND PLANNING THE DIET An extremely important function of food is to supply energy. The energy value of food is variously referred to as its fuel or caloric value. In food chemistry the unit used to measure the caloric value of food substances is the large calorie which is the amount of heat necessary to raise the temperature of 1 kilogram of distilled water from zero to 1° 0. The energy or heat value of foods is determined by the use of calorimeters, experiments with which have shown that foods furnish the same amount of 584 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY energy when used in the body as when burned in calorimeters, providing the end products in each case are the same. Experiments also have shown the fuel values for the different classes of foods to be approximately as follows: 1 Gm. of protein yields 4 calories. 1 Gm. of fat yields 9 calories. 1 Gm. of carbohydrate yields 4 calories. The food requirements of individuals are affected by several factors, muscu- lar activity, age, size, shape and weight, body composition, influence of ductless glands, pathological conditions, pregnancy and lactation, effect of food, climate, etc. It should be remembered that a certain amount of food is required to maintain the body at all times. The first step in determining the energy needs of the individual is to find the ideal weight according to the age and height. The weight-height-age tables put out by insurance companies and other authorities may be used for this purpose. From the standpoint of good health, it is considered undesirable to be underweight before 30 or overweight after that age. This makes the weight at 30 years of age in the tables ideal for most adults. Tables of average heights and weights are given immediately hereafter. Table of Average Heights and Weights—Men [From Nutrition and Diet Therapy—Proudfit] OiOCnOptOOtOC* Age COCCCOCOtOtOtOH- O Cn^O0i-*00O5fcO-gi-. O 05 lO 05 M 6 feet, 11 inches iMM M O 05 tO M H* td 6 feet, 0 inches Ot H-O00 05t0C»C005^J 6 feet, 1 inch C0c0t00 00 OOMCTfCCCO^CDH-tO 6 feet, 2 inches M WtOtOMMMMM CCOOcO®00*^05 Cnrf*-tOOCnOrf*-05^l 6 feet, 3 inches tOtOfcObOfcO^^^r-* hmOOOOOOOO^ fc0t-‘COO5t-‘O5?Ot-‘b0 6 feet, 4 inches tototobototo^j-*!--4 HHHHOOtCOOM eD-4Cnt0-vJH-^05-^ 6 feet, 5 inches Table of Average Heights and Weights—Women [From Nutrition and Diet TherapyProudfit] CnC^rf^^WCOtOhO'-* 0«ODtOC«OOiOCn ►> CD KJMMmmmOOO Ot Oi M CO cn to CD 05 H 4 feet, 8 inches totototo*-“-‘H*oo 4 feet, 9 inches tOWtOtOMMMMO C0005M003W001 4 feet, 10 inches WWlOtOtOHHMO l-*t-‘00OtH-‘00CntOO5 4feiet, 11 inches OOGOCOtOtOtOH-H-O WWOMCOO*^^^ 5 feet, 0 inch 00C000t0t0fcCl-‘H-O CnCnfcOcOCnfcOCOCscO 5 feet, 1 inch COWWWbOtOtCMM OOOOOifcO^J^t—COtO 5 feet, 2 inches H*1 H-'H M m m m m m 1 MH00 0iO^rf*-t0Cn 5 feet, 3 inches OOCnOO 5 feet, 4 inches OOOOOOtOOO^h-OObO 5 feet, 5 inches WU)0 05tOGOCnt0 05 5 feet, 6 inches 00 01W005M0050 5 feet, 7 inches 05 CO o 5 feet, 8 inches Oj t—4 QO O C*3 00 5 feet, 9 inches H I© rf*. H Vj K M 5 feet, 10 inches 5 feet, 11 inches hhhmmmmmh •^■sIMOOiOJOiCnCn 6 feet, 0 inch After the ideal weight for age and height has been determined, the influence which activity has on food requirements must be considered and calorimeter DIETS AND MESSING 585 studies of individuals in different states of activity have shown the require- ments to be as follows: require- Activity Calories per kilo Total calories Basal ... 20 1, 200-2,000 1,300-2, 200 1, 600-2,500 1, 800-3.000 2, 200-4,000 Bedrest _ 25 Light work ..... __ 30 Moderate work .. ... 35 Heavy work ... 50 After determining the total amount of food required it is necessary to determine how much protein, fat, and carbohydrate should be used to supply the desired number of calories. There is some difference of opinion as to this, although it is known, to a fair degree of accuracy, the amount of each which can be utilized to the best advantage. The total amount of food required depends largely upon the amount of exercise taken. The protein metabolism, however, does not depend so much upon the amount of exercise as it does upon the amount of food taken. It is known that carbohydrates and fats protect the body protein, and if a diet is used which is low in protein, nitrogen equilibrium may be obtained by adding fats and carbohydrates to the diet, providing, of course, the protein intake does not fall below the minimum require- ment. Ordinarily the protein intake, to supply the average body requirements, need not exceed 120 Gm. nor be under 60 Gm. daily, and the optimum probably lies between these figures, varying with the individual conditions. As regards the amount of fat and carbohydrates in the average diet, there is also some difference of opinion, although the figures do not vary as much as for the protein. It is an easy matter to determine the quantities of carbohydrates, proteins, and fats necessary to produce any number of calories in a diet by using the percentages of distribution of each class of food and the caloric value of each. If, in a diet having a distribution of 50 per cent carbohydrates, 15 per cent proteins, and 35 per cent fats, it is desired to provide a total of 2,400 calories, it is first found that— Carbohydrates should furnish 50 per cent of 2,400 calories or 1,200 calories; Proteins should furnish 15 per cent of 2,400 calories or 360 calories; and Fats should furnish 35 per cent of 2,400 calories or 840 calories. Having found the number of calories to be furnished by each class of food, by using the caloric values of each class as given before in this section, it is next found that there will be required to furnish a total of 2,400 calories: or 300 Gm. of carbohydrates; 360-M, or 90 Gm. of proteins; and 840-5-9, or 93.3 Gm. of fats. In planning a diet in an individual ease it should be remembered that undernutrition lessens the natural power of resistance to diseases, while overeating puts unnecessary strain on the organs of digestion and elim- ination, favors obesity, and increases the amount of waste products. Prob- ably the best way to work out a diet is first to determine the number of calories required, of which amount, from 10 to 15 per cent should be fur- nished by protein. The nature of the protein should be considered, and those containing the necessary amounts of amino-acids should be included. The 586 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY proteins found in milk and meat are, as a rule, more valuable than those in vegetables. The remainder of the calories is made up from fats and carbohydrates. These are interchangeable within certain limits. Ordinarily the amount of fat taken does not exceed 60 to 100 Gm. per day and the balance is made up of carbohydrates. The diet also should contain the various salts needed in metabolism and in a general mixed diet they are almost always present, although in restricted diets the quantity may be too low. In ordinary diets the requirements are easily met if milk products, salads, and other green vegetables are included and the importance of so including them must be emphasized. Foods ordinarily should furnish more bases than acids, and meats, cereals, and other acid-forming foods should be offset by those containing alkalies, as potatoes, bananas, vegetables, and fruits. The inclusion of vitamins is important and necessary. There always should he an antiscorbutic in the diet such as some fresh fruit or vegetable. The food also should contain sufficient bulk. Flavors and condiments have no nutritive value, but are used to increase the appetite by rendering food more palatable and adding savor to the diet. Spices are represented by such substances as ginger, cinnamon, nut- meg, and cloves; flavoring extracts by vanilla, lemon, and strawberry; and condiments by mustard, horseradish, pepper, salt, and vinegar. Beverages, as tea and coffee, may be regarded as stimulants due to the effect of caffeine; cocoa contains carbohydrates, fats, and proteins. The various meat extracts contain little in the way of food value, but have a stimulating effect on the digestive secretions. An adequate diet for a normal individual should consist of foods producing sufficient calories to maintain ideal body weight, of which carbohydrates fur- nish 50 to 75 per cent, proteins 10 to 15 per cent, and fats 35 to 50 per cent of the total caloric requirements, and the protein requirement may be con- sidered for estimating purposes as 0.66 to 1.5 Gm. per kilogram of standard weight. In such an adequate diet there should be the amounts of inorganic mineral salts and vitamins shown in the following table: Minerals Vitamins A—5,000 to 6,000 International units. B—400 to 500 International units. Iron (0.015 Gm) C—1,200 to 1,500 International units. D—Amount for adults not definitely known but it is essential that foods containing it be provided in the diet. Foods known to contain the other vitamins should be used gen- erously in the diet. The composition of an adequate diet is shown in the following table: DIETS AND MESSING 587 Vitamins Cal. in Phos. in Iron in Food Portions in household measures in Gms. in Gms. Gms. Gms. Gms. Gms. A B C Q 480 24.0 16.0 19.0 0. 576 0.446 0. 0012 1, 200.0 96.0 9.6 288.0 960 1 qt. (child). - 48.0 32.0 38.0 1.152 0.892 0.0024 2. 400.0 192.0 19.2 576.0 150 77.5 12. 5 2.5 0.075 0.375 0. 0030 220.0 50 6.7 5.2 0.033 0.090 0.0015 550.0 25.0 65.0 45 0. 45 36.0 0.0072 0.0076 0.00009 1, 287.0 120 30.0 22.0 0.016 0. 320 0. 0044 80.0 60.0 163.2 60 20.0 5.0 2.0 0.019 0.126 0.0011 60.0 22.0 4.0 0.106 0.043 0.0004 100 to 150 12.0 1.0 0.045 0.021 0. 0005 67.0 60.0 65.0 35.0 100 15.0 0.5 0.5 0.007 0.012 0.0004 80.0 25.0 25.0 20.0 50 11.5 0.6 0.1 0.004 0.014 0.0003 137.5 15.0 9.0 17.5 Vegetables: 10% string beans - 100 % cup (if young estimate as 6%) - . _ _ 7.7 2.4 0.2 0.050 0.051 0.0010 1,000.0 40.0 25.0 25.0 100 4.0 1.0 0.5 0.010 0.026 0.0004 1, 500.0 17.5 15.0 6.5 100 19.0 2.0 0.050 0.051 0.0010 40.0 40.0 15.0 25.0 120 5. 5 3.0 22.0 0.112 0.096 0.0002 750.0 15 15.0 1 scant tbsp. * 13 0.5 11.0 ? ? ? 45 45.0 Pifdding (cornstarch) (?) 3 rounded tbsp _ . __ 26.0 3.0 3.5 0.018 0.084 0.0002 ? ? 7 ? 304.7 88. 15 124.5 2.1282 1, 7626 0.01569 6, 691. 5 758.5 1636 633.2 Total calories, nutrients, to to to to to to to to to to and vitamins 2678 to 2987.9 328.7 104.15 143.5 2. 7042 2. 2086 0. 01689 7,891.5 854.5 173.2 921.2 Analysis of Adequate Diet (From Nutrition and Diet Therapy—Proudfit) 154294°—39 88 588 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The foods contained in the adequate diet analysed in the preceding table may be used in a menu arranged as follows: Breakfast: Fruit—1 orange with 2 teaspoonfuls sugar; Cereal—1 serving, with Cream (medium)—% cup and 2 teaspoonfuls sugar if desired; Egg—1 whole, prepared as desired; Bread—1 to 2 slices with 2 teaspoonfuls butter; Beverage—1 glass milk for children; Jam, or equivalent—1 tablespoonful. Luncheon or Supper: Cereal (macaroni)—1 serving cooked with 1 ounce grated cheese; Fruit— Vegetable— Salad dressing—J 1 small banana; lettuce, 3 to 5 small leaves; 2 teaspoonfuls mayonnaise or salad dressing; ll serving Bread—2 slices, whole-grain preferred ; Milk—1 glass ; Butter—1 tablespoonful. Fruit—1 serving applesauce (1 medium cooked with 1 tablespoonful sugar) ; Cream (medium)—2 tablespoonfuls. Dinner: Meat—1 serving roast beef; Potato—1 medium ; v , J10%—1 serving string beans (if very young, will come under 5% group) , ege a es|g% tomato, raw (medium) ; Salad dressing—1 tablespoonful; Bread—1 slice ; Butter—i teaspoonfuls ; Dessert—1 serving rice, tapioca, or cornstarch pudding. As a knowledge of the composition, use, and digestibility of foods is essential in the planning of diets, the principal food substances are next discussed briefly. Animal foods. The flesh of animals, poultry, and fish is classed as meat and is one of the most important articles of food. Meat is man’s chief source of protein and contains muscle tissue, connective tissue, blood vessels, nerves, and lymphatics, together with a varying amount of fat. Cooking has the effect of rendering connective tissue soluble and allowing the digestive secretions to mingle more freely with the muscle fibers. It also improves the flavor and appearance of the meat and destroys bacteria which may be present in the meat. Beef.—An ox from 3 to 5 years old supplies the best beef. The meat of a very lean animal will contain about 75 per cent of water and 2 per cent of fat. The muscles least exercised are the most tender and make the best roasts and steaks. Beef juice is nutritious when properly prepared and con- tains from 5 to 10 per cent of protein. Veal.—Veal is more difficult to digest than beef and is obtained from calves 6 to 10 weeks old. In some persons it tends to produce digestive disturbances and is to be avoided in cases of digestive disability. Mutton.—Mutton is obtained from the 3- to 5-year-old sheep and is consid- ered by some writers more digestible than beef. Lamb.—Is obtained from sheep less than a year old and is as digestible as beef or mutton but contains relatively too much fat. Pork.—Pork is the most indigestible of all meats on account of the large percentage of fat it contains. Ham and bacon.—Ham and bacon are both more digestible than pork. When cooked crisp, thin slices of bacon are digested easily. 589 DIETS AND MESSING Animal viscera.—Animal viscera are not quite so nutritious as most meats. Tripe, liver, kidney, and brains are used extensively. The heart is tough and indigestible. Sweetbreads, either the pancreas or the thymus gland of the calf, are digested easily. In recent years liver and kidney have been used exten- sively in the diet because of their vitamin and iron content. Liver and the extract therefrom are specific in the treatment of pernicious anaemia. Poultry.—Chicken is one of the most digestible and agreeable varieties of meat. Squab is also a desirable and easily digested food. Game birds are digested easily and are richer in extractives. Fish.—Fish is used very widely as a food and is always best used in season. Fish are in best condition just before spawning. After this process they be- come thin and unfit for food. Fish undergo decomposition rapidly and as a rule should be eaten in as fresh condition as possible. Shell fish (oysters, clams, and mussels) may be eaten raw or cooked. Oysters, when eaten raw and fresh, are very digestible but when cooked are less easily digested. Eggs.—Hens’ eggs are consumed in large quantities and those of the duck, turkey, guinea hen, and wild fowl also are eaten. Eggs contain mainly protein and fat in addition to water and are extremely valuable in the diet because of their vitamin and mineral content. Eggs are highly nutritious and when served with milk or broth form an important article of diet for convalescent patients. Milk.—Milk is probably the most important of animal foods, containing all the elements necessary for the maintenance of life. It forms the exclusive diet for young growing mammals but is unsuited as an exclusive diet for adults. It contains about 4 per cent of fat, 3.3 per cent of protein, 5 per cent of carbo- hydrate, 0.7 per cent of mineral matter, and 87 per cent of water. Milk is a valuable source of vitamins A, D, and G. Heat is employed in keeping milk, usually by two methods—either sterilization or pasteurization. Sterilisation is accomplished by boiling for 10 minutes or longer. There are certain objections to sterilized milk as boiling kills the ferments and places milk in the class of so-called “dead foods.” It may be used to advantage, however, in very hot weather when ice is not available. Pasteurisation means heating milk to a de- gree sufficient to kill harmful bacteria but with the least possible effect upon its value as a food. See page 382 for pasteurizing methods. While pasteurization kills most of the bacteria, particularly the pathogenic bacteria, it does not render the milk sterile; however, it does not materially change the composition of the milk as does sterilization. Pasteurized milk must be kept cool to prevent deterioration. Vegetable foods. Vegetable foods differ from animal foods in that they contain more starch and sugar and a relatively small amount of protein. Cereals.—These are the most important of the vegetable foods and to this class belong wheat, corn, rye, oats, barley, rice, and buckwheat. The cereals are supplied chiefly in the form of flour or meal. Legumes.—Peas and beans are the most important legumes and contain a liberal proportion of protein. Lentils are used comparatively little in the United States, but are used extensively in other countries. Peanuts belong to this class and differ from other legumes in that they contain a large amount of fat. The principal legumes, peas and beans, should be well cooked so that the cellulose enclosing the vegetable cells is broken down. Roots and tubers.—This includes potatoes, sweetpotatoes, yams, artichokes, beets, carrots, parsnips, turnips, and radishes. They contain both starch and sugar but are relatively lower in nutritive value than either legumes or cereals. 590 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Green vegetables.—Green vegetables are valuable not only on account of their nutriment but for variety and relish and for their content of salts and vitamins. They also give bulk to the food which is important on account of its mechanical action in maintaining a healthy alimentary tract. The princi- pal articles of food in this class are cabbage, cauliflower, spinach, lettuce, sorrel, tomatoes, eggplant, cucumbers, asparagus, rhubarb, pumpkin, squash, onions, and garlic. Fruits and nuts.—Fruits are used extensively as flavoring agents. Their chief nutrient constituent is sugar, the principal sugar being levulose and some- times cane sugar. The mineral elements of fruit contain potash with tartaric, stearic, and malic acids. The antiscorbutic properties of fruits are due to their salts and vitamins. Fruits also act as diuretics and laxatives. The most easily digested fruits are oranges, lemons, grapes, and peaches. Apples, pears, and bananas are slightly less digestible. Nuts contain a large quantity of fat and somewhat more protein than fruits. They are taken mainly as a dessert and as a rule do not constitute a large source of nutriment. They are not digested easily as a rule, owing to the large amount of cellulose and high proportion of fat. DIET THERAPY OR DIET IN DISEASE In feeding the sick it is advisable to carry out the patient’s wishes whenever practicable, and to a certain extent make allowance for likes and dislikes and certain idiosyncrasies. A tactful, observing, and sympathetic nurse who ac- quaints himself or herself with these facts will be of the greatest help to the medical officer in carrying on his dietary regime. The nurse should have a knowledge of practical dietetics and of the amount of food required by different types of patients. Food should be given at regular intervals. This is particularly important in semiconscious or comatose patients, and in the conscious patient regularity in meals Is also of distinct advantage. The appetite of the convalescent patient requires catering to, as patients in this condition are apt to be more fastidious than when they are well. The sick room should be neat, and no dishes, utensils, or food allowed to stand about the room either before or after using. Food and drink should be served from scrupulously clean utensils. These utensils should be as attrac- tive as possible, and the food must be dainty and appetizing in appearance. If the patient approaches his food with the flow of his digestive secretions stimulated by the psychic reaction to the odors and appearance of the food, he is in a position to get the greatest amount of good from his meal. An attrac- tive dish, garnished with sprigs of green, accompanied by clean linen and bright silverware, will go a long way toward accomplishing this result. Food that is stale or has acquired an unpleasant odor or taste from standing in a refrigerator should never be given. A strong egg in an eggnog or an odorous piece of meat may be the means of turning the patient away from much needed nourishment. The patient should be made to feel that the utmost cleanliness and care have been observed, and the face and hands of the patient should be cleansed before food is given, and the lips and teeth cleansed after the meal is com- pleted. If the mouth is dry, it should be moistened from time to time with a mixture of water, glycerin, and lemon juice. When special diets are ordered, the contents of the tray should be checked with the written orders. An error in serving a special diet may cause dis- comfort, serious illness, or even death. DIETS AND MESSING 591 If an order is given to record the intake of food or drink for a patient, it should be kept accurately and be available for the medical officer at all times; it is essential for his treatment of the patient. To recapitulate, the tray should be served with the proper diet and arranged in an attractive manner. Hot foods should be served on hot dishes and cold food on chilled dishes. A restful atmosphere is conducive to a good appetite and good digestion. Diets used in the treatment of disease are often spoken of by names that show a special composition and often indicate the purpose for which the diet is intended. Some of these names are: High-caloric, low-caloric, high-roughage, low-residue, salt-free, salt-poor, high-fat, low-fat, fat-free, fat-poor, high-calcium, high-carbohydrate, low-protein, diabetic, ketogenic, obesity, etc. A brief description of the diets suitable for certain diseases is given next. Allergies.—Food allergy diets are high-caloric diets made up from a more or less restricted dietary list. They may he made up from “elimination” diets or from the patient’s skin sensitization list. In the latter case, all foods to which he reacts positively are excluded from his diet. Anaemia.—The diet in anaemia should consist of easily digested foods rich in iron and copper, such as eggs, liver, kidney, beef and other meats, green vegetables, whole grain cereals, fresh and dried fruits, and dried legumes. Cardiac diseases.—In acute heart failure with oedema, the patient usually is placed on a restricted diet consisting of 800 to 900 cc of milk in 24 hours until the oedema tends to disappear. The transition from milk to a more solid diet is begun slowly by adding gradually soft cooked eggs, dry toast, baked potato, fish, or the white meat of chicken. Later, as the cardiac condition improves, more solid food is given, but never a large amount of food at any one meal, in order to avoid embarrassing the heart by a well-filled stomach. Constipation.—In the ordinary type of constipation, due to sluggish action of the bowel, and not due to mechanical obstruction, it is advisable to give food which tends somewhat to irritate and stimulate peristalsis, such as oat- meal, whole wheat, vegetables, fruit, and a liberal amount of water. In spastic constipation the diet is just the reverse of that employed in the atonic type. A bland, low-residue diet is given, beginning with one of the semi- liquid or soft character. Later, the diet is increased to a soft, smooth-residue one. Diarrhoea.—In the ordinary type of diarrhoea, due to an acute gastroin- testinal disorder, give bland nonirritating liquids for a diet, well-cooked and strained gruels, such as arrowroot, farina, and rice, and boiled milk. Later, as the condition improves, lean meat and fish, potatoes, simple extracts, and milk puddings may be added. Diabetes.—The diet in diabetes is one in which carbohydrates and fats are regulated by the medical officer. It is given exactly as prescribed by the med- ical officer and it is essential that the patient should eat it entirely.* Nor should he take any other food. Gastric ulcer.—Lenhartz or Sippy diet or some similar diet is probably the most generally used. This consists of hourly feedings during the first 10 days of small amounts of milk and cream, between which feedings alkalies are given by mouth. Later the feedings are given at 2-hour intervals, and at the end of 4 or 5 weeks five or six feedings a day are given, with gradual addition of semisolids and later solid foods. Long Island College Hospital ulcer diet is another diet successfully used in the treatment of gastric ulcers. It includes milk, toast, butter, cream, cooked 592 HANDBOOK OF THE HOSPITAL CORPS, V. S. NAVY cereals, soft cooked eggs, cream cheese, simple desserts, stewed fruits, and lactose. It is served in meals three times a day with interfeedings. Gout.—Prohibit food of glandular organs, such as sweetbreads, liver, kid- neys, and all food rich in extractives, as well as acid and highly seasoned foods. The diet should consist principally of milk, cream, eggs, butter, farina, tapioca, cornstarch, extracts, ice cream, water ices, potatoes, and possibly a little boiled meat. Nephritis— In an acute attack with oedema, avoid condiments and salt in the diet and give bland, easily digested food with not more protein than is necessary to maintain the basal requirements, the balance of the diet being made up from carbohydrates and fats in sufficient amounts to maintain the caloric requirements of the individual. In some cases the Karell diet is recommended, consisting of 800 cc of milk a day, although it is not considered advisable to maintain the patient on this diet for any length of time. In, the chronic forms of nephritis this principle still holds, it being ad- visable to throw the minimum amount of work on the kidneys and to elimi- nate all irritating and highly seasoned dishes from the menu. The restriction of protein intake below that required for the actual body needs is inadvisable, as if insufficient protein is derived from the food the patient will make up the deficiency from his own tissues. As regards the amount of water a patient with nephritis should take, it is not advisable to lay down any specific rule, as the amount which should be taken in each case depends upon the ability to excrete water, and this can be ascertained readily if the amount ingested and the amount excreted is meas- ured daily. Obesity.—In obesity, determine the number of calories the patient is to have each day, giving less, of course, than the amount required to maintain the weight of the patient. Ordinarily, if a patient is up and about and can com- bine a restricted diet with a certain amount of exercise, the efforts at reduc- tion of weight will be much more effective. A diet containing 1,200 to 1,500 calories per day, together with exercise, such as walking 3 to 5 miles a day, usually will accomplish the desired result. If the patient is given foods of low caloric value such as the green vegetables, and items such as butter, cream, bread, and potatoes eliminated from the diet, he usually can get along with- out suffering inconvenience or severe hunger. Fevers.—In fever the metabolic processes are increased and the power of assimilation is lowered. In order to maintain a fever patient properly the food should be easy to take, easy to digest, and readily assimilated. Milk is the almost universally used food in this condition, but must be supplemented by additional items. Cream is of great value owing to its high caloric content, and eggs also constitute a valuable addition to the diet. Meats ordinarily are not used in fevers, although the meat juices may be used occasionally. The balance of the diet may be made up from sugars and starches, and sufficient fluid should be supplied to keep the patient comfortable. Tuberculosis.—The diet of the tuberculous patient should be ample, slightly more than the patient’s calculated requirement. It should be well balanced and not lacking in vitamins, minerals, or roughage. Protein should be liberal but not excessive. Fats should be generous, and carbohydrates in normal proportions. The food should be simple, easily digested, and well prepared. Some authori- ties believe food between meals is inadvisable because, as a rule, more will be eaten at meal times and with better enjoyment if there has been no interfeed- ing. Rest before and after meals is beneficial to the digestion. DIETS AND MESSING 593 CLASSIFICATION OF DIETS IN NAVAL HOSPITALS The diets served in naval hospitals usually are liquid, soft, light, regular, and special diets. Liquid diets are usually ordered as “clear liquid” or “full liquid.” A clear liquid diet includes clear broths, rice and barley water, black tea or coffee, jello, and strained fruit juices. A full liquid diet includes all liquids served in a clear liquid diet with the addition of strained soups, strained gruels, milk and milk drinks, ice cream, and junket. Soft diet includes all liquids in addition to well-cooked cereals, Italian pastes, white bread and crackers, soft-cooked eggs, cottage cheese, soft cream cheese, tender fish, chicken, minced tender lamb and beef, sweetbreads, and brains. Baked, mashed, escalloped, and creamed potatoes, and pureed vege- tables are also given on a soft diet. The desserts used are custards, gelatin puddings, simple cakes and cookies, cooked fruits without seeds or heavy fiber, and ripe bananas. Light diet includes all articles given in the soft diet as well as prepared cereals, whole-wheat bread, creamed or grated cheese, steaks, chops, bacon, tender roast lamb or beef, fish, and liver. The vegetables allowed, not purded, are asparagus, peas, string beans, spinach, carrots, beets, squash, tomatoes, and lettuce. All cooked fruits, citrus fruits, olives, and mayonnaise are allowed. Regular diet is the diet served to the general mess. Special diets include the Lenhartz, Sippy, Karell, and other special dietaries which are indicated in some particular diseases and which are prescribed by the medical officer for some particular case. SPECIAL METHODS OF FEEDING Special methods of feeding include rectal feeding, duodenal alimentation, nutrient inunctions, intravascular injection, saline irrigations and saline in- fusions. Nutrient enemata.—This is the term applied to the administration of food by rectum. With careful technique, a patient may be fed by rectum for a period of several weeks, although it is doubtful if more than one-sixth to one-fourth of the total caloric requirements can be supplied in this manner. The rectum first should be cleansed thoroughly by high injection of physiological salt solu- tion an hour before the enema is to be given. This cleansing enema should be given at least once a day. Nutrient enemata may be indicated in extremely weakened conditions when the quantity of food taken through the mouth is insufficient to maintain life; in obstruction of the pharynx or oesophagus, and in paralytic conditions of the pharynx when the patient is unable to swallow food; in diseases of the stomach, as in cancer with stricture and in delirious, comatose, or insane per- sons who cannot be fed by mouth. In feeding by rectum it must be remembered that the large intestine has no power of digestion, apparently absorbs little besides water and salts, and there is but little possibility that food administered in this way will reach the small intestine where most of digestion takes place. Consequently in feed- ing by rectum only predigested foods or foods in an immediately absorbable form, such as dextrose solution, should be given. The usual nutrient enema consists of milk, which has been pancreatized for 24 hotirs and boiled, about 8 ounces, to which may be added either 2 to 3 drams of dextrose, 2 to 3 drams of alcohol, 1 or 2 yolks of eggs, or a combination of all three. 594 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The nutrient enema usually is given by the drop method and it is sometimes advisable to add 10 or 15 drops of tincture of opium as a sedative. Duodenal alimentation.—This consists of feeding through a duodenal tube which has been introduced through the stomach and is a desirable way of feeding a patient in conditions in which the stomach needs a rest. Nutrient inunctions.—Particularly if oils such as olive oil, cod liver oil, coconut oil, or cocoa butter are used, nutrient inunctions are sometimes of value, especially in infants suffering from marasmus or malnutrition. Intravascular injection.—This consists in introducing fluid into a vein, usually in the form of salt, alkaline, and dextrose solutions. It usually is practiced as an emergency measure and not as a routine procedure. Subcutaneous feeding.—This method of administration is somewhat unsatis- factory, but solutions of dextrose in physiological salt solution and also olive oil have been given in this manner. Saline irrigation and infusion.—Saline Irrigations by rectum are especially useful in such conditions as luemorrhage and in various acute fevers when it is inadvisable to give fluids by mouth. They serve to allay thirst and are a very useful means of increasing the amount of fluid in the system. Saline infusion given subcutaneously is useful in cases where the patient cannot retain a rectal solution and usually is given in the chest, lumbar region, abdo- men, or buttock. RECIPES Peptonized Milk (Warm process) Put one-half cup (gill) of cold water and the powder contained in one peptonizing tube into a clean quart bottle and shake thoroughly; add a pint of cold fresh milk and shake again; then place the bottle in a pail or kettle of warm water at about 115° F., or not too hot to immerse the whole hand in it without discomfort. Keep the bottle in the water bath for 5 or 10 minutes, or longer if it is desired to peptonize the milk quite completely, then put it immediately on ice in order to check the process of digestion and keep the milk from spoiling. The container should be placed directly in contact with the ice. The degree of peptonization is regulated very simply in this process by the length of time during which the milk is kept in the water bath. It is seldom necessary to peptonize milk until it becomes bitter. In the following formulas for preparation of food for the sick, those marked with an asterisk (*) are quoted from “Dietetics for Nurses,” by F. T. Proudfit: * Okangeade Juice of 1 orange. 1 tablespoonful sugar. Juice of % lemon. Enough water to fill the glass. * Albuminized Okangeade Make orangeade as directed in preceding recipe without the addition of water. Break the whites of two eggs into a saucer and with scissors cut the albumin until free from membrane and strain, stir this into the orange juice and add several pieces of cracked ice. This is both nourishing and palatable, and the taste of the egg cannot be detected. 1 egg. % tablespoonful sugar. Speck of salt. Egg Nog % cup milk. Flavor with nutmeg. Beat the egg, add the sugar and salt; blend thoroughly, add the milk and nutmeg. Serve immediately. DIETS AND MESSING 595 2 teaspoonfuls cocoa. V2 teaspoonful sugar. * Cocoa y2 cup boiling water. % cup milk Mix cocoa and sugar together and add boiling water slowly. Boil 3 to 5 minutes; heat milk in double boiler and add cocoa mixture. Beat with egg beater to distribute cocoa and prevent scum forming. Serve with or without whipped cream. Cocoa may be reinforced with albumin or the whole or yolk of one egg well beaten. If the white alone is used, care must be observed that the liquid is not hot enough to coagulate the albumin. Proprietary foods and casein preparations are used in like manner. * Malted Milk Chocolate or Cocoa 1 tablespoonful malted milk. 1 tablespoonful cocoa or grated choco- late. 6 ounces milk. 2 ounces water. y2 teaspoonful sugar. 4r-5 drops vanilla extract. Mix cocoa or chocolate with water and boil 2 to 3 minutes. Pour milk into a double boiler and heat, mix malted milk with a little water and stir into the hot milk, add the cocoa paste, sugar, and vanilla, beat the mixture briskly to mix ingredients thoroughly, and serve with or without cream. 1 ounce (3 tablespoonfuls) chocolate. 1 cup boiling water. Chocolate Syrup 1 y2 cups sugar. 1 tablespoonful of vanilla. Put chocolate in a saucepan and add the water gradually, stirring all the time. Add sugar and stir until it begins to boil; boil 3 minutes, strain, cool, and add 1 tablespoonful vanilla. Bottle and keep in a cold place. Chocolate Shake (Individual rule) 2 tablespoonfuls chopped ice. 2 tablespoonfuls chocolate syrup 3 tablespoonfuls whipped cream. y2 cup milk. % cup soda water or carbonated watei. Shake or stir well before drinking. A tablespoonful of vanilla ice cream is a desirable addition. It is a delicious drink, even if the soda or carbonated water is omitted. A plainer drink is made by combining the syrup, three-fourths cup milk, and the ice, and shaking well. * Coffee 2 tablespoonfuls ground coffee. 2 teaspoonfuls white of egg. 1 cup boiling water. M cup cold (boiled) water. Mix coffee with 1 tablespoonful of cold water and egg white in small pot (after scalding pot), add boiling water; allow to boil 3 minutes; stir down and add cold water; set pot where coffee will stay hot, but not boil, for 10 to 15 minutes, serve with cream and sugar or to flavor. * Coddled Egg 1 egg 1 pint water. Allow water to boil; wash egg; drop into boiling water and place saucepan where water will keep hot, but not boil; allow to stand 7 or 8 minutes. Serve with salt. 596 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY * Soft Cooked Egg Proceed as for coddled eggs, but allow egg to remain from 10 to 15 minutes or even longer, if very soft eggs are not desired. Have small, shallow saucepan half filled with boiling water or milk, if an egg poacher is at hand, use that; otherwise, lower a flat perforated spoon into water and place where the water cannot boil. Break the egg carefully into the spoon, taking care not to break the yolk; allow to stand in hot water until the white is of the consistency of jelly; lift out, slide egg on to hot toast, taking care not to break. (A broken poached egg is very unappetizing, as well as untidy in appearance). * Poached Egg Scrambled Egg Wash an egg, break it into a small frying pan, add a teaspoonful of butter, 2 tablespoonfuls of milk, and pinch of salt and shake of pepper. Put over heat, and stir just enough to keep from sticking to pan. Allow mixture to become jellylike, remove, and serve on hot buttered toast. Toast a slice of bread to golden brown, have about a pint of boiling water, put in a teaspoonful of salt. Dip the toast in boiling water and take it out again very quickly, then butter lightly, and serve at once. This form of toast can be used in case of sore mouth. Water Toast Toast a couple of pieces of bread to golden brown. Put on 1% cups of milk and bring to a scalding point. Add one-fourth teaspoonful salt. Butter the toast, cut in strips, and place in bowl. Pour on the scalding milk and serve. Milk Toast * Baked Custard 1 egg. 1 tablespoonful sugar. % cup milk. A few drops of vanilla. Beat eggs and sugar together, stir into milk, grease custard cup with butter, pour in the mixture. Set cup on several layers of paper in a deep pan, surround with hot water (to about half its depth). Set pan in moderate oven and allow to cook slowly until custard is firm in the center. It may be served hot or chilled, and turned out, with a tablespoonful of whipped cream on top. Care must be taken not to allow the oven to get hot or the egg will coagulate, making a watery, unpalatable, and indigestible mixture. * Soft Custard 1 egg (or 2 yolks). 1 tablespoonful sugar. 1 cup milk. A few drops of vanilla. Heat milk in double boiler. Beat egg and sugar together. When milk has reached the scalding point (small bubbles form around the edge of the sauce- pan), stir in the egg. Care must be taken not to allow the water under the saucepan to become too hot, as the custard will curdle if the egg is cooked at too high a degree of temperature. The custard must be stirred constantly in the beginning until it begins to thicken, then several times a minute until it is of the desired consistency and the raw taste is cooked out of the egg. This mixture is done when it will form a coating upon the spoon. Serve with whipped cream on top. DIETS AND MESSING 597 Beef Tea with Hydrochloric Acid Select one-half pound of good beef; remove everything that is not clear meat. Chop it fine. Put in pint fruit jar and add 1 cup cold water and 5 drops diluted hydrochloric acid. Stir and set in refrigerator or any cold place for 2 hours to digest. Then strain, season with salt, and serve in dainty china cup on account of color. If one should object to color, heat the tea in a double boiler just till color changes. Do not strain. Beef tea made in this way is recommended by physicians for feeble children and patients much weakened by sickness. Select a piece of meat from the rump or top of the round. Remove all fat and broil or warm slightly 1 or 2 minutes, to set free the juices; lay on plate and cut meat in various directions that more juice may be extracted; then squeeze out the juice by means of a press, lemon squeezer, or potato ricer into a slightly warmed cup. Salt if necessary, and serve at once. Prepare only enough to serve, as it does not keep well. Serve in dainty china cup to disguise color. One pound of meat yields 4 ounces of juice. Beef Juice 1 teaspoonful granulated gelatin. 1 tablespoonful cold water. 3 tablespoonfuls boiling water. Orange Jelly, (Individual rule) 2 tablespoonfuls sugar. 3 tablespoonfuls orange juice. 2 teaspoonfuls lemon juice. Soak the gelatin in the cold water one-half hotir; add the boiling water and dissolve. Add sugar and fruit juice, strain through a cloth and strainer into cold, wet mold. Cocoa Junket (Individual rule) 1 tablespoonful cocoa. 2 teaspoonfuls sugar. 2 tablespoonfuls boiling water. 1 cup milk. % Junket tablet. 1 teaspoonful cold water. 3 drops vanilla. Mix the cocoa, sugar, boiling water, and cook over heat and rub to a smooth paste; add gradually the fresh cool milk. Heat until lukewarm (not more), add vanilla and then tablet dissolved in the cold water. Pour mixture im- mediately into sherbet cups, partly full. Stand in warm room undisturbed until firm, like jelly, then put on ice to cool. Dietetics for Nurses.—Proudfit. Nutrition and Diet Therapy.—Proudfit. Diet Manual, St. Mary’s Hospital, Rochester, Minn.—Sister Mary Victoria. Nutrition.—Chaney and Ahlborn. Nutritional Charts.—H. J. Heinz Co. Research Department. Foods Rich in Vitamins A, B, C, D, E, G, and the P-—P Factor.—Munsell and Daniel.— U. S. Department of Agriculture Bulletin. Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. References CHAPTER VIII PHARMACY From the vegetable, mineral, and animal kingdoms of Nature are obtained the medicinal substances used for the alleviation of disease and for the restoring or the preserving of health. Pharmacy is the science which treats of medicinal substances. The study of pharmacy embraces not only a knowledge of medicinal sub- stances and of the art of preparing, compounding, and dispensing them, but also of their identification, selection, preservation, combination, analysis, and standardization. The discovery of new medicinal drugs and the making of organic compounds are Important functions of scientific pharmacy. The word pharmacy is also used as the name of a place where medicines are sold, and it is derived from the Greek word pharmacon, meaning “a drug, a medicine.” For convenience in studying pharmacy, this science is divided into two major classes: Theoretical Pharmacy and Practical Pharmacy. As all Nature is called upon to provide the remedies used in the healing art, it follows that the sciences which contribute to a thorough understanding of the vegetable, mineral, and animal substances used as medicines, and the sciences which treat of the laws governing them, furnish many of the important facts forming the basis of scientific pharmacy, and that a knowledge of those sciences is essential to theoretical pharmacy. Theoretical pharmacy is that branch of pharmacy which treats of the sub- stances used as medicines and of the laws governing them. The following sciences comprise theoretical pharmacy: Botany, the science of plants. Mineralogy, the science of inorganic substances found in and on the earth. Zoology, the science which treats of animals. Physics, the science which describes and explains the changes produced in substances by which their original identity is not destroyed. Chemistry, the science which treats of those changes produced in substances affecting or altering their original identity. Materia medica, the science which treats of the medicinal materials used for cure or the prevention of disease. Pharmacognosy, the science which treats of crude drugs. Toxicology, the science which treats of poisons, their sources, effects, and antidotes. Microscopy, the science of examining the minute structure of substances by the aid of the microscope. Bacteriology, the science which treats of microorganisms. Serology, the science which treats of serums. Biology, the science which treats of life. Pharmacodynamics, the science which treats of the action of drugs and their effects upon the various organs and functions of the body. Pharmacology, the science which treats of the nature and properties of drugs. 600 HANDBOOK OF THE HOSPITAL CORPS, XL S. NAVY Upon the sciences of physics and chemistry pharmacy is most dependent for its greatest development and for its highest degree of usefulness. Practical pharmacy is that branch of pharmacy which treats of the opera- tions, processes, and methods used in applying the principles of theoretical pharmacy. Practical pharmacy is sometimes known as operative pharmacy. In the Navy the practice of pharmacy is concerned primarily with the com- pounding and dispensing of remedial agents according to the prescription of the medical officer or to the instructions given in authoritative texts. Com- pounding is the skillful blending of two or more ingredients. Dispensing is the transferring of a substance from one container to another for any one of several reasons. In civil life compounding and dispensing are the acts which legally distinguish the practice of pharmacy from the mere selling of drugs and remedies. The principal books used in the study and practice of pharmacy are the United States Pharmacopoeia, the National Formulary, dispensatories, and textbooks on the principles and practice of pharmacy. The United States Pharmacopoeia is an authoritative book containing a list of standardized medicinal substances, with descriptions, tests, and formulas for preparing them. The medicinal substances listed in it are recognized as official, and the word “official” as applied to a drug or preparation means that it is listed only in the Pharmacopoeia. It was first published in the year 1820, by the doctors of the United States who before that time had no national standard for the medicines and preparations they were using. It has been revised every 10 years since 1820 and the present revision is known as the eleventh, abbreviated U. S. P. XI. The Pharmacopoeia is owned, edited and revised by the United States Pharmacopoeial Convention which is incorporated under the laws of the District of Columbia. This convention is made up of delegates appointed from the professions of medicine, dentistry, pharmacy, and chemistry. The U. S. Pharmacopoeia recognizes nearly all the drugs and preparations that are considered by the medical profession as essential in the treatment of the sick or in the prevention of disease. Exceptions are some of the valuable medicines of recent discovery and medicines whose composition or method of preparation is kept secret or that are controlled by patent rights. It establishes the official titles, abbreviation, dose, and synonym of each substance, and defines, describes, establishes the purity, gives tests for the identity, assay processes or methods for determining the strength, chemical formula, source in the case of animal and vegetable drugs, and instructions for the preservation of nearly all the medicines which it contains. The Pharmacopoeia is recognized by the Federal and State Governments in the enforcement of food and drugs acts as the standard for the articles listed therein when they are used for medicinal purposes only. Medicinal substances of sufficient importance to be given a place in the Pharmacopoeia are indicated by— 1. The official Latin title. Example: Dnguentum Phenolis. 2. The official English title. Example; Ointment of Phenol. 3. The abbreviated title. Example: Ung. Phenol. 4. The synonym. Example: Ointment of Carbolic Acid. 5. The botanical name (in the case of plants). Example: Capsicum frutescens. 6. The symbolic formula (in the case of chemicals). Example; NasSO^lOILO. Latin, being universally used and understood as the language of science because it is a dead language and not liable to change, is selected for the official PHARMACY 601 title of the substances named in the Pharmacopoeia. The official Latin titles of those substances are therefore distinctive and precise, and there is almost no possibility for error. The official English titles are used in ordinary conversa- tion and in commercial transactions. The abbreviated titles provide uniformity in use and help to prevent mistakes in reading and compounding prescriptions. Synonyms are usually from old and unscientific sources but through common custom and long usage they have become so well established that they cannot be entirely ignored or abandoned. The botanical name is the name for plants that is recognized by botanists; it serves as the basis of the official name in the Pharmacopoeia and its use is absolutely necessary in establishing the identity of any vegetable drug, for the Pharmacopoeia names the particular variety of a plant that is recognized as official. The symbolic formula is a combination of certain arbitrary symbols used to briefly and exactly state the composition of a chemical. The Purity Rubric was first introduced into the U. S. P. VIII to limit the quantity of permissible harmless impurities in chemicals, by stating in terms of percentage the amount of pure substance that must he present. Its use has been continued and extended to drugs and many other articles in the Pharmacopoeia. Doses are given in the Pharmacopoeia in both the metric and apothecaries systems, but the figures are not interchangeable, nor are they to be considered as exact equivalents. Under the term average dose are stated the doses which may be expected ordinarily to produce the therapeutic effect for which the preparation is most commonly employed. The doses when administered orally are those for human adults, unless otherwise indicated. The method of administration is named whenever necessary. The National Formulary is a book containing a list of extensively used drugs and preparations that are not included in the Pharmacopoeia. The medicines which it contains are recognized because of their extensive medicinal use and pharmaceutical soundness, rather than their therapeutic value. A drug to be recognized by the Pharmacopoeia must not only be extensively used, but it must also have well-recognized therapeutic properties, or be used in the prep- aration of some other medicine in the Pharmacopoeia. A drug to be recog- nized by the National Formulary, however, need only be extensively used and pharmaceutically sound. This difference makes the National Formulary a book of secondary importance to the Pharmacopoeia. Many of the drugs and preparations listed in the National Formulary were at some time contained in the Pharmacopoeia, and, as they were dropped from time to time, the National Formulary took them up, because they were still used by many members of the medical profession in different parts of the country, and because they were extensively used, it was necessary there should be some standard by which they could be prepared. The National Formulary is owned, edited, and revised by the American Pharmaceutical Association. It is revised every 10 years, usually following the revision of the Pharmacopoeia. In the last revision the policy of adopting only those preparations and drugs cast aside by the Pharmacopoeia was discontinued. It is recognized by the Federal and State Governments in the enforcement of the food and drugs acts as the standard for the articles listed therein when they are used for medicinal purposes only. A Dispensatory is a commentary on the United States Pharmacopoeia, the National Formulary, the pharmacopoeias of other countries, and, in addition, contains information about most of the substances that have been or are now 602 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY used in the cure or prevention of disease. It is an excellent reference book for one studying pharmacy or medicine, as it gives a complete description of the physical, medical, and pharmaceutical history of medicinal substances, their preparation and properties, constituents and compounds, uses, action and doses, tests and assays, etc. METROLOGY Metrology is the science of weights and measures, and treats of the measures of length, surface, volume, and weight. The word is derived from Greek words meaning measure and discourse. Weight is defined as the difference between the attraction of the earth and that of surrounding bodies for bodies on the surface of the earth. The weight of a body depends upon its bulk and density, density being the amount of matter in a given bulk of the body. Weighing is the balancing of a body of known gravitating force with one whose gravity is not known in order to estimate and determine the gravitating forces of the latter, which is called its weight Weights are bodies of known gravitating force used for weighing. The apparatus used for weighing are scales or balances and weights. Weights are based upon standards known as the grain and the meter. The weights and measures in general use in the United States are avoir- dupois, used in commercial buying and selling; troy, used by jewelers; apothecaries, used by pharmacists in compounding; and metric, used almost entirely in scientific work and research. The grain weight was established by King Henry III of Great Britain in 1266 in an act in which he decreed in part that “An English silver penny called the sterling, round and without clipping, shall weigh 32 grains of wheat, well dried and gathered out of the middle of the ear.” This statute was reiterated by Edward I in 1304. The metric system of weights and measures has for its fundamental unit the meter, which is the distance equal to one ten-millionth part of a quadrant of longitude running through Paris, France. The length of the meter is usually defined as the one forty-millionth part of the circumference of the earth around the poles. The metric system of weights and measures, also known as the French and the decimal system, originated in France as a result of suggestions that there be a standard for scientific measurements. The French Assembly in 1790 appointed commissions to study and report on such a standard and these com- missions decided upon the meter as the unit of length, drew up a system of weights and measures based on the length of the meter, and fixed the nomen- clature. The system of weights and measures and the nomenclature were established by law in 1795 but it was not until 1799 that the report on the length of the meter was made. On December 10, 1799, a law definitely fixed the value of the meter and of the kilogram, or weight of a liter of water. Use of this system has been adopted by nearly all countries but has never been made compulsory in the United States where, however, its use was legallized by an Act of Congress passed in 1866 which also directed its use in the medical department of the Army and Navy and the Marine hospital service. The Secretary of the Navy in 1878 directed that this system be used in the Medical Department of the Navy and its use has also been adopted by many scientific bodies in this country. In Paris, France, there are preserved the models of the meter and kilogram from which all prototypes are made. Since 1875 there has been in Paris, France, an International Bureau of Weights and Measures managed by an PHARMACY 603 International Committee composed of representatives of all civilized nations. This committee makes and provides prototypes of the model meter and kilo- gram for the subscribing nations. The United States prototypes, made of a platinum-iridium alloy, are kept in the Bureau of Standards at Washington, D. G. and are used for standardizing all the weights and measures used in the United States. The denominations of this system are multiplied by the Greek words deka, meaning ten; hecto, meaning hundred; and kilo, meaning thousand, and are divided by the Latin words deci, meaning one-tenth; centi, meaning one- hundredth ; and milli, meaning one-thousandth. The metric system is divided into four branches but only three of these are ordinarily used in pharmacy. They are the measures of length, of volume or capacity, and of weight. The unit of length is the meter, which is the one forty-millionth part of the circumference of the earth around the poles1 and is equivalent to 39.37 inches. The unit of volume or capacity is the liter, which is the volume of one cubic decimeter. It is also defined as the volume occupied by the mass of 1 kilogram of distilled water at its maximum density (4°C.). It is equivalent to 2.1134 pints. The unit of weight is the gram, which is the weight of one milliliter of distilled water at its maximum density (4° C.). It is equivalent to 15.432 grains. The unit of microscopic measurement is the micromillimeter, or micron, which is a thousandth part of a millimeter. The denominations most commonly used in pharmacy are the kilogram, the gra'm, the milligram, the liter, and the milliliter. Metric prescription weights are usually supplied in two denominations, the gram and the milligram. Nearly all small graduates are graduated in mils or milliliters (another name for the milliliter is cubic centimeter, abbreviated ce) and measures of more than 1,000 mils capacity are usually graduated in liters. The volume of one cubic- centimeter was officially adopted for general use as the capacity unit in the U. S. P. XI, which states that 1 liter equals 1000.027 cc, and that 1 Gm. of water at 4° C. measures 1.000027 cc. Use of “cc” instead of “mil” is therefore correct. The conversion of ordinary weights or measures into metric weights or measures and vice versa is not difficult and involves only simple mathematical procedures and the use of the figures given in the next paragraphs. To convert metric weights or measures into those in ordinary use multiply the metric quantities by the corresponding equivalent. Therefore, to convert: Meters into inches, multiply by 39.370. Liters into fluidounces, multiply by 33.815. Grams into grains, multiply by 15.432. To convert the weights or measures in ordinary use into metric weights or measures multiply the quantities by the corresponding equivalent. Therefore, to convert: Inches into meters, multiply by 0.0254. Fluidounces into milliliters, multiply by 29.572. Grains into grams, multiply by 0.0648. The avoirdupois ounce contains 437.5 grains, the apothecaries 480, and the weight of 1 fluidounce of distilled water is 454.6 grains. In the avoirdupois pound there are 7,000 grains and in the apothecaries 5,760. A gallon contains 231 cubic inches. 154294°—39 39 604 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The table of equivalents of weights and measures immediately following is given in order that the student may become familiar with the relations existing between the different systems. Equivalents of Weights and Measures English System Metric Equivalent Avoirdupois weight: 1 grain gram. 0.0648 437.5 grains make 1 ounce (oz.) ... _ _ grams. . 28.35 16 ounces make 1 pound Gb.) .. do.__ . 453.60 100 pounds make 1 hundredweight (cwt.). 20 hundredweight make 1 ton. Apothecaries weight: 1 grain ... gram 0.0648 20 grains make 1 scruple O) _ _ ... . _ grams. 1.30 3 scruples make 1 dram (3) do... 3.90 8 drams make 1 ounce (5) do... . 31.103 12 ounces make 1 pound do... . 373.236 Troy weight: 1 grain gram. 0.0648 24 grains make 1 pennyweight (dwt.) grams. 1.555 20 pennyweights make 1 ounce do... . 31.103 12 ounces make 1 pound-.. .. do... . 373.236 Apothecaries measure: ... .cubic centimeter 1 minim (0.95 grain) (Til) 0.06 60 minims make 1 fluidram (f3) do... 3.70 8 fluidrams make 1 fluidounce G5) do__. . 29.57 16 fluidounces make 1 pint (O) do... _ 473.18 8 pints make 1 gallon (Cong.) do... . 3,785.40 Linear measure: 1 inch — millimeters 25.4 12 inches make 1 foot centimeters. . 30.48 3 feet make 1 yard - _ . -- .. ... ..meter. 0.914 5.5 yards make 1 rod (or perch). 40 rods make 1 furlong. 8 furlongs make 1 mile do... . 1,609.35 Metric System English Equivalent Length: Kilometer, 1,000meters - ... mile % Hectometer, 100 meters. Decameter, 10 meters. Meter (unit) .inches. 39. 37 Decimeter, one-tenth meter .. do... 3.937 Centimeter, one-hundredth meter do... % Millimeter, one-thousandth meter do__ V* Capacity: Kiloliter, 1,000 liters. Hectoliter, 100 liters Decaliter, 10 liters. Liter (unit), cube of one-tenth meter fluidounces 33.814 Deciliter, one-tenth liter. _ do... 3.3814 Centiliter, one-hundredth liter __ do___ Vi Milliliter, one-thousandth liter (ml) ... minims. 16.23 Weight: Kilogram, 1,000 grams fapothecaries ounces. ■ ■ 1 avoidupois ounces. 32.15 . 35.27 Hectogram, 100 grams. Decagram, 10 grams. Dram (unit) . 15.432 Decigram, one-tenth gram 1.5 Centigram, one-hundredth gram do... v> Milligram, one-thousandth gram Hi Apothecaries Metric A tumblerful... 240 cc AteacupfuL. —fSiv... 120 cc A wineglassful fBii 60 cc A tablespoonful. fjiv— 16 cc A dessertspoonful f3ii—- 8 cc A teaspoonful. - f3i 4cc Approximate measures Balances and measures. A balance is an instrument for determining the relative weights of sub- stances, or, for weighing. If accurate results are to be obtained in the use of a balance it must be correctly constructed, skillfully used, and carefully protected from injury. A balance is frequently called a scales, a term who«« use is not desirable. PHARMACY 605 Pharmaceutical balances may be classified according to the type of their construction as: 1. Single beam, equal arm; 2. Single beam, unequal arm; 3. Double beam, unequal arm; 4. Compound lever balance; and 5. Torsion balance. Of these, the types most commonly used in pharmacy are the single beam, equal arm, and the torsion balance. In analytical work the balance used has to be much more sensitive than the average pharmaceutical or prescrip- tion balance and great care and accuracy is required in its construction. One type of analytical balance is called the Chainomatic balance. In the construction of the single beam, equal arm balance, a beam is sus- pended on a knife-edge, which divides it into equal arms, and knife-edges are placed at each end of the beam on the same plane and at exactly equal distances from the point of suspension to support the pans which carry the substances to be weighed. The construction of the single beam, unequal arm balance can be seen by inspecting the well-known Fairbanks scales. This type of balance de- pends on the principal in physics: “The power is to the weight or resistance in the inverse ratio of the arms of the lever.” The longer arm of the beam is graduated for a movable weight, the use of which dispenses with small weights and is a decided advantage. In the double beam, unequal arm balance the construction is the same as given before, but with two parallel beams, and is employed for weighing liquids, etc., the outside beam being used to tare the bottle or jar. A compound lever balance is well shown in Fairbanks platform scales. It is used on druggists’ counters and sometimes for prescription scales. A torsion balance is one in which a compound beam is balanced and sup- ported upon an immovable frame. The beam is prevented from slipping out of place, and the torsion is secured by a flattened steel wire or spring stretched upon the center frame and firmly fastened to the underside of the beam. Upon the ends of the beam are fastened the movable frames which support the pans. Motion of the beam may be arrested easily by moving the lever, and the delicacy of the balance is increased by placing a weight upon the index, whereby the center of gravity is elevated. In this type of balance knife-edges are done away with entirely. Care of a balance.—A balance should be kept in a closed case in a dry place protected from corroding vapors. The balance and scale pans should not be polished with gritty substances but should be cleaned with chamois. Steel knife edges should be coated with a very thin coating of vaseline. The beam should not be left in an oscillating position when the balance is not being used. Weights should be put on and taken off with pincers. The substance to he weighed should be placed in the left-hand pan (the pan to the left of the operator as he faces the balance) and the weights in the right-hand pan. The first step in weighing is to see that the balance is balanced, and that the knife edges are in position; then place a piece of pan-paper in each pan, and see that the balance is balanced after the paper has been placed in the pans. Put the weights in the right-hand pan, and carefully place enough of the drug in the left-hand pan to exactly balance the weights. After removing the drug, check the weights to see that the amount is right, put the weights away, and clean up the balance. In weighing substances that injure the scale pans, by their chemical action, always use glass pans or waxed paper. The weights used in pharmaceutical weighing are constructed of brass or aluminum. In the construction of metric weights, the gram weights are made of brass, lacquered to prevent oxidation, and the milligram weights are made of aluminum because it is a light metal and gives bulk to the small weights. 606 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In the construction of apothecaries weights, all weights including and above the scruple are made of brass, and the grain weights are made of aluminum. Measures.—Liquids are measured by the use of graduated vessels of tinned copper or iron, agateware, and glass. For use in the practice of pharmacy glass measures are preferable, vessels of the other materials usually being used in measuring quantities larger than 1 pint. To measure small quantities of liquids, such as minims, glass vessels known as pipettes often are used because of the assurance of accuracy. Pipettes are glass tubes with a constricted point and graduated on the side. They are used by applying suction to the upper end and holding the liquid in the tube by placing the finger on the upper end while reading off the contents. Owing to capillary attraction, the top of the liquid in a graduated pipette pre- sents a cup shape. This is called a meniscus. A line drawn through the bot- tom of the meniscus of transparent and the top of opaque liquids usually is selected as the reading point. A drop, through error, is supposed to be a minim; but though this may be approximately true when applied to water, a drop and a minim are rarely the same. This fact must be kept in mind when administering medicines or when compounding from formulas and prescriptions that call for minims or for drops. Thick viscous liquids produce large drops; heavy mobile liquids small ones. A drop of syrup of acacia is five times as large as a drop of chloroform. The size of a drop depends also upon the shape of the vessel from which dropped, upon the form of the lip, upon adhesion, cohesion, rapidity of flow, and viscosity. A drop of liquid from a curved medicine dropper is larger than one from a straight dropper having the same sized opening, because the straight one generally is held at an angle so that the drop falls from one side of the orifice, but with a curved dropper the drop falls from the whole circle of the orifice. The table following shows the variation in the number of drops for several liquids when a standard dropper having an exit with an external diameter of 3 millimeters which will discharge 20 drops of water of such size that they will weigh 1 Gm. is used. Number of Drops Obtained From a Standard Dropper Liquid Drops per gram Drops per cc Drops per fluidram Drops per minim 20.0 22.2 81. 5 1. 36 19.5 23.8 88.0 1. 46 22.9 40.0 148.0 2. 46 65.5 50.0 185. 0 3.10 Chloroform - _ _ . ... . 58.8 100.0 370.0 6.16 37. 4 45. 5 160.0 2 70 90.0 66.5 246.0 4.10 52.6 50.0 185.0 3 10 23. 1 33. 3 123.0 2.05 41. 5 50.0 185. 0 3.10 35. 5 40.0 148.0 2. 46 21.1 22. 2 81.5 1. 36 18. 7 28. 6 106.0 1. 76 65. 5 59.0 218.0 3. 63 56.3 50.0 185.0 3.10 48.1 50.0 185.0 3.10 53.3 65.5 205.0 3. 41 50. 8 50.0 185.0 3.16 50.9 50.0 185.0 3.10 57.3 50.0 185.0 3.10 63.3 66.5 246.0 4.10 As recommended by the Brussels Conference, temperature 15° C. or 59° F. Specific Gravity (abbreviated sp. gr.) is the weight of one body compared with the weight of an equal bulk or volume of another body selected as the standard, both bodies having the same temperature, or the temperature of each being PHARMACY 607 definitely known. The substance taken as a standard is distilled water for solids or liquids, and air for hydrogen or gases. Example: If at a certain temperature 1 cc of distilled water (the standard) weighs 1 Gm., and 1 cc of mercury at the same temperature weighs 13.5 Gms., the specific gravity of the distilled water is 3.000 and the specific gravity of the mercury is 13.500. Methods by which specific gravity may be taken are: 1. By the specific-gravity bottle (pycnometer). 2. By the use of Lovi’s beads. 3. By the use of the Westphal specific-gravity balance. 4. By the use of hydrometers (urinometer, lactometer, alcoholometer, sac- charometer, etc.). Because of certain physical characteristics solids are grouped under the following heads when their specific gravity is taken: 1. Solids insoluble in, and heavier than water. 2. Solids soluble in, and heavier than water. 3. Solids insoluble in, and lighter than water. 4. Solids soluble in, and lighter than water. A different procedure is necessary wdien taking the specific gravity of a solid belonging to one of these groiips. As the weights of bodies are proportionate to their masses, and as the amount of matter in, or the mass of, a given bulk of a body is termed its density, it is evident that the specific gravity of a substance is equivalent to its density. Consequently the term density is frequently used in place of spe- cific gravity. The specific gravity, or density, of a substance has a direct bearing on its purity, and therefore specific gravity is made use of in determining the strength or purity of drugs and preparations. In the Pharmacopoeia and in the National Formulary, under the description of a drug the specific gravity is frequently stated, especially when it would be of value in determining the strength or purity of the substance. The strength of alcohol, ammonia water* nitric acid, sulfuric acid, or hydrochloric acid can readily be determined by taking their specific gravity. Specific gravity tables for some substances have been worked out and are printed in the Pharmacopoeia. Specific Volume (abbreviated sp. vol.) is the volume of one body compared with the volume of an equal weight of another body selected as the standard, both bodies having the same temperature. Example: If, at a certain tempera- ture, 100 cc of alcohol weighs 82 Gms., and the same weight of distilled wTater at the same temperature measures 82 cc, the specific volume of the alcohol will be as the volume of the alcohol (100 cc) is to the vojume of the distilled water (82 cc). Dividing 100 by 82 gives 1.22, which is the specific volume of the alcohol. Specific volume is directly the opposite of specific gravity for, while specific gravity deals with what weight of a certain substance will go into a certain sized bottle, specific volume asks what sized bottle will hold a certain weight or amount of that substance. PHARMACEUTICAL ARITHMETIC The rules of arithmetic apply to problems in pharmacy in exactly the same way as they apply to any other practical use of arithmetic. In pharmaceutical arithmetic accuracy is absolutely necessary, for an incorrect calculation or the. misplacing of a decimal point can mean the difference between life and death, 608 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Addition, subtraction, multiplication, division, fractions, decimals, percentage, ratio, and proportion all find their uses in the arithmetic of pharmacy. A brief explanation of how to prepare solutions and mixtures of different strengths will now be given. The strength of a solution or mixture is the proportion of active substance or drug to the solvent, vehicle or base, and is usually expressed in one of two ways: 1. By the percentage method; or 2. By the ratio method. The percentage method will first be considered. Percentage means parts per 100 parts. In pharmaceutical and chemical problems percentage refers to parts by weight unless parts by volume is specifically stated. In the Pharmacopoeia and in the National Formulary the term “per cent” is frequently used in stating the purity standard of the drug or preparation, preceded by a number. There also it refers to parts by weight unless parts by volume is specifically stated. Percentage solutions, for convenience in preparation and administration, are divided in the Pharmacopoeia into three classes: Weight in weight (w/w) solu- tions; Weight in volume (w/v) solutions; and Volume in volume (v/v) solutions. A weight in weight percentage solution is one containing in every 100 Gms. of finished solution, the number of grams of the drug corresponding to the percentage strength. Thus a 5 per cent (w/w) solution of cocaine hydro- chloride in water contains in every 100 Gms. of solution 5 Gms. of cocaine hydrochloride and 95 Gms. of water. It must be clearly understood that 100 Gms. of a weight in weight solution does not always measure 100 cc; in some cases it may measure more than 100 cc, but usually it will measure slightly less than 100 cc. The only absolutely accurate type of percentage solution is the weight in weight but because of certain disadvantages it is not prepared as often as the weight in volume type. It is difficult to prepare a weight in weight solution because it is necessary to weigh the liquids used in its preparation which makes it impracticable in dispensing, especially when liquids other than water are used as solvents. Because of the contraction in volume that takes place in making solutions it is necessary to make more than the volume called for and results in a waste of the drug. In administering such solutions it is not a simple matter to calculate the amount of drug contained in a tea- spoonful or in a certain number of cc. Because of these disadvantages the weight in volume and the volume in volume types of percentage solutions are much more popular. A rule for determining the amount of drug and the amount of solvent to be used in making a stated number of grams of a weight in weight (w/w) solution is: Rule.—Multiply the number of grams of solution desired by the per cent expressed as a whole number; divide the product by 100; and the quotient will be the number of grams of drug required; subtract this from the number of grams of finished solution, and the remainder will be the number of grams of solvent to use. Instead of expressing the per cent as a whole number and dividing by 100, a common practice is to express the per cent decimally (0.05 for 5 per cent), multiply, and use the product as shown before. Problem.—Make 100 Gms. of 5 per cent (w/w) solution of silver nitrate in water. One hundred multiplied by 5 equals 500; 500 divided by 100 equals 5; and 100 minus 5 equals 95; or, 100 multiplied by .05 equals 5, and 100 minus 5 equals 95. Answer.—Dissolve 5 Gms. of silver nitrate in 95 Gms. of water. The finished solution will weigh 100 Gms. but will measure slightly less than 100 cc. PHARMACY 609 A weight in volume (w/v) percentage solution is one containing in every 100 cc of finished solution the number of grams of drug corresponding to the percentage strength. Thus a 5 per cent weight in volume (w/v) solution of silver nitrate contains in every 100 cc of finished solution 5 Gms. of silver nitrate and enough solvent to make 100 cc of solution. As liquids are administered by volume instead of by weight it is easier to calculate doses, or the amount of drug contained in a given volume of a solution, if the strength of the solution is expressed in grams of solid or cc of liquid drug in every 100 cc of solution. The uniform relation between the milliliter (cc) and the gram in the metric system makes calculations very simple in preparing such solutions. This is the type of solution that is usually desired when a percentage solution is called for. A rule for determining the amount of drug and the amount of solvent to be used in making a stated number of cc of a weight in volume percentage solution is: Rule.—Multiply the number of cc of solution desired by the per cent expressed as a whole number; divide the product by 100 and the quotient will be the number of grams of drug required. To this is added enough solvent to make the desired number of cc of finished solution. Problem.—Make 75 cc of a 5 per cent (w/v) solution of silver nitrate in water. Seventy-five mul- tiplied by 5 equals 375; 375 divided by 100 equals 3.75. Answer.—Dissolve 3.75 Gms. of silver nitrate in enough water to make 75 cc of finished solution. A volume in volume (v/v) percentage solution is one containing in every 100 cc of finished solution the number of cc of liquid drug corresponding to the percentage strength. Thus a 5 per cent (v/v) solution of glycerin in water contains in every 100 cc of finished solution 5 cc of glycerin and enough water to make up the volume to 100 cc. A rule for determining the amount of drug and the amount of solvent to be used in making a (v/v) percentage solution is; Rule.—Multiply the number of cc of solution desired by the per cent expressed as a whole number; divide the product by 100; the quotient will be the number of cc of drug required. To this is added enough solvent to make the desired number of cc of finished solution. Problem.—Make 500 cc of a 3 per cent (v/v) solution of glycerin in water. Multiplying 500 by 3 equals 1,500; dividing 1,500 by 100 gives 15. Answer.—Measure out 15 cc of glycerin and to it add enough water to make 500 cc of finished solution. In making percentage mixtures of solid or semisolid substances the weight in weight (w/w) percentage method is used. Problem.—Make 2,000 Gms. of an ointment containing 10 per cent of sulfur, using benzoinated lard as a base. How much sulfur and how much benzoinated lard is required? Multi- plying 2,000 by 10 equals 20,000; dividing 20,000 by 100 gives 200; and 2,000 minus 200 equals 1,800. Answer.—Use 200 Gms. of sulfur and 1,800 Gms. of benzoinated lard to make the ointment. It is often desired to know the percentage strength of a solution or a mixture made according to a formula or prescription. A simple rule for determining the percentage strength of a solution or a mixture is: Rule.—Multiply the number of grams (or cc in the case of a volume in volume solution) of active drug used by 100 and divide the product by the number of grams (cc in the case of weight in volume solution or a volume in volume solution) of solution or of mixture. Problem.—What is the percentage strength of a solution that contains 2 Gms. of cocaine in 50 Gms. of solution? Two multiplied by 100 equals 200 ; 200 divided by 50 equals 4. Answer.—Four per cent. Problem.— What is the percentage strength of an ointment that contains 1 Gm. of yellow oxide of mercury in 30 Gms. of the ointment? One multiplied by 100 equals 610 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 100, which, divided by 30 equals 3.33. Answer.—Three and thirty-three hun- dredths or 3% per cent. In arithmetic ratio is the expression of the relation or of the comparison of two quantities. The two quantities compared are called the terms of the ratio. In the ratio 8 to 16, 8 is called the first term or antecedent and 16 the second term or consequent. Ratio is that number by which the second term must be multiplied to produce the first. As in any comparison, the two terms of a ratio must be of the same denomination before the relation between them can be found. A ratio may be expressed in three ways: By the sign of division (8-K16) ; by a fraction (%e) ; or by a colon (8:16). The value of a ratio is found by dividing the first term by the second term, and if the answer is a fraction it is reduced to its lowest terms. Problem.—What is the ratio of 2 yards to 4 feet. Two yards equals 6 feet; 6 feet: 4 feet equals 6: 4 equals % equals % equals iy2. Answer.—The ratio of 2 yards to 4 feet or 6 feet to 4 feet is 1%. In the ratio method of expressing the strength of a solution the strength is expressed by stating the number of grams of solution (w/w) that contain 1 gram of the drug; the number of cc of solution (w/v) that contain 1 gram of the drug; or the number of cc of solution (v/v) that contain 1 cc of the drug. A 1 in 10 (sometimes written 1-10) weight in weight solution contains 1 gram of drug in every 10 grams of finished solution. A 1 in 10 weight in volume solution contains 1 Gm. of the drug in every 10 cc of finished solution. A 1 in 10 volume in volume solution contains 1 cc of the drug in every 10 cc of finished solution. Ratio solutions are usually prepared in strengths as follows: 1-10, 1-20, 1-50, 1-100, 1-200, 1-500, 1-1,000, etc., using round numbers to simplify calculations. A rule for determining the amount of drug and the amount of solvent to be used in making a stated number of grams of a weight in weight solution by the ratio method is: Rule.—Divide the number of grams of solution desired by the larger number of the ratio and the quotient will be the number of grams of the drug to be used; subtract the number of grams of the drug from the number of grams of finished solution and the remainder will be the number of grams of solvent to use. A rule for determining the amount of drug and the amount of solvent to he used in making a stated number of cc of a weight in volume solution is; Rule.—Divide the number of cc of solution desired by the larger number of the ratio; the quotient will be the number of grams of the drug to be msed, and to this is added enough solvent to make the desired number of cc of finished solution. A rule for determining the amount of drug and the amount of solvent to be used in making a stated number of cc of a volume in volume solution by the ratio method is: Rule.—Divide the number of cc of solution desired by the larger number of the ratio; the quotient will be the number of cc of the drug to be used and to this is added enough solvent to make the desired number of cc of finished solution. Problem.—Make 500 cc of a 1-20 (v/v) solution of glycerin in water. Five hundred divided by 20 equals 25; take 25 cc of glycerin and to it add enough water to make 500 cc of finished solution. Alligation, or “the rule of mixtures,” is an arithmetical rule relating to the solution of problems concerning the compounding or mixing of different in- gredients, or ingredients of different qualities or values, and is so named from the method of connecting together the terms in a problem by lines. It is made use of in pharmacy to determine the amounts of two or more strengths of a given substance needed to blend into a new, intermediate PHARMACY 611 strength of that substance. It is also applied in making adjustments of per- centage or ratio strengths, and of specific gravities. When the different strengths of a substance to be blended and the new strength of that substance are expressed in terms of percentage, the following is the procedure undertaken in determining the quantities of the different strengths at hand required to produce the new strength desired: Draw a horizontal line and above the center of it write the new or desired percentage; below the same line write the different percentage strengths of the substances to be mixed and draw a short vertical line downward from each; with a horizontal line link together the line below each percentage figure that is greater than that desired with one that is less; draw another horizontal line below the lines linking the percentage figures together and below this last line write the differences between the desired percentage and the percentages given, placing the difference for a lesser percentage under the greater percentage with which it is linked and the difference for a greater percentage under the lesser percentage with which it is linked. The numbers placed below the lowest line will be the numbers of parts by weight of each strength to be used in making a mixture having the new or desired strength. It must be remem- bered to always link together a quantity which is less with one wMcth is greater than the desired percentage. A simple problem in which it is desired to know how many parts of a 9 per cent mixture and of a 14 per cent mixture would be required to make a 12 per cent mixture would be expressed thus: Nine is subtracted from 12, leaving 3, which figure is placed under the 14, and 12 is subtracted from 14, leaving 2, which figure is placed under the 9 ; there- fore it takes 2 parts of a 9 per cent mixture and 3 parts of a 14 per cent mixture to make 5 parts of a 12 per cent mixture. It is desired to know in what proportions four solutions of silvol containing 5, 10, 25, and 40 per cent (w/w) respectively wnuld have to be mixed to obtain a solution containing 20 per cent of silvol. Express the problem thus: By subtracting 5 from 20, 20 from 40, 10 from 20. and 20 from 25, it is found that it will take 20 parts of 5 per cent, 5 parts of 10 per cent, 10 parts of 25 per cent, and 15 parts of 40 per cent solutions of silvol to produce a 20 per cent solution, and as these are w/w solutions the parts represent grams of the solutions. By adding the lowest row of figures it is found that there would be 50 Gms. of the 20 per cent solution of silvol. The problem 612 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY may be proved as follows: Multiply the numbers of parts used by the per- centages, add the columns of parts and answers, and divide the larger by the smaller. The result of this division should be the percentage desired if the operations are correct. 20X 5= 100 5X10= 50 10X25- 250 15X40- 600 50 )1000(20 155_ 0 0 It is desired to make 500 Gms. of a 20 per cent (w/w) solution from the solutions of different strengths previously named; what quantities of each solution will be required? As it has been found by alligation that a total of 50 parts of the solutions of different strengths are required to make a 20 per cent solution, to make 500 Gms. of the 20 per cent solution will require the use of 99 of 500 Gms. or 200 Gms. of the 5 per cent solution, A of 500 Gms. 50 50 or 50 Gms. of the 10 per cent solution, 99 of 500 Gms. or 100 Gms. of the 25 50 15 per cent solution, and — of 500 Gms. or 150 Gms. of the 40 per cent solution. 50 Following is the proof that these quantities are correct; 55 of 500 = = 200 50 50 — of 500= 5g>5 = 50 50 50 15 of 500- 50 50 — of 500- 5|55=150 50 50 55 of 500-55555=500 50 50 Reducing the fractions in the left hand column to decimals and then mul- tiplying the amount of the 20 per cent solution to be made by them will also give the quantities of the different strength solutions to be used. The problem can also be solved by the use of proportion, that process in arithmetic known as the equality of ratios or the relation between quantities. A ratio consists of two terms; a proportion of four. In a proportion the two outside terms are called the extremes and the two inner terms are called the means. In the proportion 8 : 4:: 160 : 80, 8 and 80 are the extremes, and 4 and 160 are the means. This proportion is read: 8 is to 4 as 160 is to 80. In a proportion the product of the extremes is equal to the product of the means, and for the proportion given 8X80 equals 4X160 or 640 equals 640. If one of the extremes in a proportion is missing, it can be found by dividing the product of the means by the extreme given, and likewise, if one of the means is missing, it can be found by dividing the product of the extremes by the given mean. The missing term is expressed by the letter x. In the proportion 8:4:; 160 : x, find the missing term. = X; cancelling, = 80; O $ the missing term is 80. PHARMACY 613 In working with proportion certain rules must be remembered. Those rules are: 1. Let “x” always be the fourth term: 2. Let the third term be that num- ber in the question which expresses the same kind of value as is expected in the answer; 3. Decide whether the answer sought will be greater or less than the third term, and if greater, the larger of the two remaining terms belongs in the second place, but if smaller, the lesser of the two remaining terms belongs in the second place; and 4. The remaining term goes in the first place. To solve the problem of the solutions of different strengths by proportion, state the proportions as follows; (а) 50 : 20 :: 500 : x;20X500=x; cancelling, = 200; x = 200 (б) 50 : 5 :: 500 : x; = x; cancelling, — X^0 10 = 50; x= 50. (c) 50 : 10 :: 500 : x; *QXf00 = x; cancelling, >0X500 100; x= i00, 50 50 {d) 50 ; 15 : : 500 ; x; .15X^00 = x; cancelling, 15X^0 --=150; x=150 50 50 Therefore, to make 500 Gms. of a 20 per cent solution of silvol 200 Gms. of a 5 per cent solution, 50 Gms. of a 10 per cent solution, 100 Gms. of a 25 per cent solution, and 150 Gms. of a 40 per cent solution of silvol will be required. PHARMACEUTICAL OPERATIONS AND PROCESSES Heat.—From the time of the ancient Greeks different theories have been advanced to explain the nature of heat. The one now almost universally accepted is known as the dynamical theory of heat which assumes that heat is produced by the constant motion of the particles composing the body, and that heat varies in quantity dependent upon whether the body is solid, liquid, or gaseous. The kinetic theory of matter states that the molecules of all matter are in perpetual motion, striking against and rebounding from each other, and by that motion producing heat. It may therefore be said: Heat is that form of molecular motion, or molecular kinetic energy, which produces the sensation called warmth. More simply: Heat is a form of molecular motion. The sun is the most important source of heat. Friction, electricity, light, and chemical action all produce heat and may be said to be sources of heat. Rub- bing two pieces of wood together to kindle fires, and igniting substances from sparks obtained by striking a flint and steel together are examples of heat produced by friction; electricity passing through wires having high resistance to the passage of electricity, as in an electric toaster, is an example of produc- ing heat by electricity; igniting a substance by concentrating the rays of the sun on it through a “burning glass” is an example of heat produced by light; the mixing of alcohol and water with the formation of hydrates of alcohol, and the burning of fuels are examples of the production of heat by chemical action. Chemical action is an important source of heat and by chemical action is meant the breaking up of the molecules of a substance with the formation of new molecules. In chemical action, sometimes called decomposition, there is considerable movement of the molecules and their constituent atoms, which movement is a form of friction and therefore produces heat. The combining of iron with iodine in a test-tube in the presence of water, forming ferrous iodide, produces so much heat that the test-tube becomes so hot it can hardly be held in the hand. This is an example of heat produced by chemical action. The burning of wood is another example of heat produced by chemical action, but 614 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the chemical action here is much different from that in the other example, because not only is the heat produced of greater intensity, but flame, or light, is also produced. This is due to the heat being so great and the reaction so rapid that some of the carbon in the wood fails to combine with oxygen and, becoming heated, glows as does the carbon filament in an incandescent light. Chemical action accompanied by heat and light is called combustion. Any substance with which a combustion can be had is called a fuel. Fuels may be solid, as wood, charcoal, coal, coke, etc., liquid, as alcohol, kerosene, gasoline, petroleum, benzine, etc., or gaseous, as natural and artificial gas. In the burning of fuels it is necessary to have apparatus suitable for the fuel used. Heat performs work according to the quantity of heat present. To measure the quantity of heat the unit used is the calorie. The calorie is the amount of heat required to raise the temperature of 1 Gm. of distilled water from zero to 1° C. This is known as the small calorie and there is also the large calorie which equals 1,000 small calories. The large calorie is generally used in expressing the energy or heat value of food substances. There is a difference between heat and temperature which must be remem- bered. Heat is quantity or amount while temperature is quality, degree, or intensity. A gallon of water at 100° C. is just as hot as a barrel of water at 100° C. because the temperature is the same, but the quantity or amount of heat in the barrel of water is very much greater than that in the gallon of water. The intensity of heat is known as its temperature, the degree of intensity is determined by instruments called thermometers and is expressed relatively in degrees. A thermometer is a glass tube with a capillary bore, sealed at one end and the other end terminating in a cylindrical or globular bulb which is usually filled with mercury. When subjected to the influence of heat the mercury ex- pands and rises in the tube, the degree of heat being read either on a graduated scale marked on the tube or on a graduated scale placed at the side or back of the tube (fig. 146). The lower limit of accuracy of a mercury-filled ther- mometer is —30° C. because mercury freezes at —40° C.; the upper limit of accuracy of a mercury-filled thermometer is about 300° C. because mercury boils at 350° C. If that part of the capillary tube above the mercury column be filled with an inert gas, such as nitrogen, the mercury will be prevented from boiling by the pressure of the gas above it, and such a thermometer may be used for temperatures as high as 550° O. The three scales used in marking thermometric degrees are Fahrenheit, Centigrade, and Reaumur. In the Fahren- heit scale the freezing point of water is 32, the boiling point is 212, and the intervening space is divided into ISO degrees. In the Centigrade scale the freezing point of water is zero, the boiling point is 100, and the intervening space is divided into 100 degrees. In the Reaumur scale the freezing point of water is zero, the boiling point is 80, and the intervening space is divided into 80 degrees. The Reaumur scale is rarely used in English-speaking countries. Most thermometers in use in the United States are graduated either in the Centigrade or the Fahrenheit scale, and some thermometers have both scales. Statements of temperature are given in the U. S.' Pharmacopoeia in Centigrade degrees. The standard temperature for making specific gravity determinations. Figure 146.—Ther- mometers ; from left to right, Fahr- enheit, Centigrade, Reaumur, (Rem- ington.) PHARMACY 615 solubility tests, polarimetric determinations, and for the preparation of volu- metric solutions is 25° C. (U. S. P. XL) It is often necessary to convert the degrees of one scale into those of another, and in converting Centigrade degrees into Fahrenheit degrees or vice versa, it should be kept in mind that 100 degrees Centigrade are equal to 180 degrees Fahrenheit, or that 1° C. is equal to 1.8° F. It should also be kept in mind that on the Fahrenheit scale the freezing point of water is 32 degrees above zero or 32 degrees higher than on the Centigrade scale, and this difference of 32 degrees must be considered. With temperatures above the freezing point of water, to convert Fahrenheit degrees to Centigrade degrees the rule is: Subtract 32 from the number of Fahrenheit degrees and divide the remainder by 1.8. Problem.—Convert 122° Fahrenheit to Centigrade; 122 minus 32 equals 90; 90 divided by 1.8 equals 50; the answer is 50° C. With temperatures above the freezing point of water, to convert Centigrade degrees to Fahrenheit degrees the rule is: Multiply the number of Centigrade degrees by 1.8 and to the product add 32. Problem.—Convert 50° C. to Fahren- heit ; 50 multiplied by 1.8 equals 90; 90 plus 32 equals 122; the answer is 122° F. With temperatures below the freezing point of water, to convert Fahrenheit degrees to Centigrade degrees the rule is: Add 32 to the number of degrees below the freezing point and divide the sum by 1.8. Problem.—Convert —31° F. to Centigrade; 31 plus 32 equals 63; 63 divided by 1.8 equals 35; the answer is —35° O. With temperatures below the freezing point of wTater, to convert Centigrade degrees to Fahrenheit degrees the rule is : Multiply the number of degrees below the freezing point by 1.8 and from the product subtract 32. Problem.—Convert —35° O. to Fahrenheit; 35 multiplied by 1.8 equals 63; 63 minus 32 equals 31; the answer is —31° F. Heat is applied and temperature is controlled in pharmaceutical operations by the use of heat baths. Some of the commonly used heat baths are the water bath, salt-water bath, glycerin bath, oil bath, sand bath, etc. If it is desired to heat a substance at a temperature of 100° C., for some time, a water bath is used. It does not matter how much heat is applied to the water bath, the temperature will not go any higher than 100 degrees because this is the boiling point of water. The temperature of a liquid does not increase after it reaches the boiling point (unless confined), but the boiling points of different liquids vary greatly; the boiling point of water is 100° C., glycerin about 260° C., saturated solution of salt water about 108° C.; therefore, if it is desired to heat a substance no higher than 100° C., use a water bath; if a temperature of 106° O. is desired, use the salt water bath, etc. The sand bath is used for very high temperatures and must be cautiously used if a constant temperature is desired. Wire gauze is used under glass vessels when they are subjected to the direct heat of a flame to prevent them from breaking. Pharmaceutical operations requiring the application of heat. Not all pharmaceutical operations which require the application of heat are made use of in the retail drug store or the dispensary, most of them being employed only in manufacturing establishments and in laboratories when drugs are tested and analyzed. In these operations the degree of heat used varies from what is called gentle heat to strong heat. In the definitions of these operations or processes which follow, the degree of heat used is named whenever it is essential to the process: 616 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Ignition consists of strongly heating inorganic substances, with access of air, to obtain a definite residue. Incineration is the process of strongly heating, or burning, organic substances in a crucible until nothing but ashes remain. This process is made use of in making analyses of certain organic substances. Fusion is the process of liquefying solid substances by the application of heat without the use of a solvent. An example of this process is the melting of wax. Calcination is the process of separating volatile substances, such as carbon dioxide, from fixed inorganic matter by the application of strong heat, without producing fusion. Magnesium oxide and calcium oxide (quick lime) are made by heating (calcining) the carbonates of magnesium or calcium wiiich drives off tlie carbon dioxide and leaves behind the oxide. (MgCOs+heat—>MgO+C02), Deflagration is the process of strongly heating one inorganic substance with another capable of yielding oxygen (usually a nitrate or a chlorate). Decom- position ensues, accompanied by a violent, noisy, or sudden combustion. Salts of antimony and arsenic may be made by this process. Carbonization is the process of strongly heating organic substances without the access of air until they are charred. The volatile prodiicts are driven off and the non-volatile products, principally carbon, remain behind. Charcoal is made in this way. Torrefaction is the process of moderately heating, or roasting, organic substances. The roasting of coffee is an example of the application of this process. Vaporization is the process of separating volatile substances from fixed bodies or from less volatile bodies, usually with the aid of heat at varying temperatures. The use of this process has four principal applications as follows: 1. To separate a volatile liquid from a less volatile liquid, when it is called evaporation. 2. To separate a volatile liquid from a solid, when it is called desiccation, exsiccation, or granulation. 3. To obtain a volatile liquid, when it is called distillation, 4. To separate a volatile solid from a nonvolatile solid, when it is called sublimation. Evaporation, as used in pharmacy, is the process of driving off the more volatile or less valuable portions of a liquid by the application of heat with the object either of purifying or concentrating the liquid for the purpose of obtaining the less volatile portion. An example of evaporation is the con- centrating of liquids intended for crystallization. Ebullition, or boiling, is an important form of evaporation. Desiccation is the process of depriving solid substances of moisture at as low a temperature as possible. The moisture driven out is known as hygro- scopic moisture to distinguish it from the moisture 'combined in chemical salts as water of crystallization. This process is used to aid in the preserva- tion, to reduce the bulk and weight, and to facilitate the comminution of medicinal substances. Exsiccation is the process of depriving a solid crystalline substance of its water of crystallization or moisture by heating it strongly. The object of this process is to reduce the bulk and volume of substances. Exsiccated alum (burnt alum) is made by heating crystalline alum. Granulation is the process of heating the solution of a chemical substance with constant stirring until nearly all of the liquid is evaporated and a coarse-grained powder is produced which usually is composed of very small PHARMACY 617 crystals. In granulation the solution is first evaporated rapidly, the heat then is moderated, and toward the end of the process the heat is very moderate. Distillation is the process of heating liquids or solids until gas or vapor is driven off and condensing all or some of the gas or vapor back into the liquid which is sought. The first part of the process is identical with evap- oration ; the second part, called condensation, is the conversion of the vapor into a liquid by the application of cold. Distillation is extensively used in retail and in manufacturing pharmacy and there are three modifications known as fractional, destructive, and vacuum distillation. Fractional dis- tillation is the process of separating mixed liquids having different boiling points. The liquids having low boiling points distill over first and in that way can be separated from those having high boiling points. Destructive distillation is the process of heating dry organic matter in a distillatory ap- paratus until the substance is decomposed and new products are formed, volatilized, and condensed. Oak wood subjected to this treatment breaks down into wood alcohol, acetic acid, acetone, creosote, and other products; coal, when subjected to this treatment yields illuminating gas, ammonia products, phenol bodies, cresols, benzene, toluol, dye color bases, and other products, while coke is left behind. Vacuum distillation is the process of facil- itating evaporation by the removal of air pressure from the distilling chamber which permits the operation to be conducted at a lower temperature. The special advantages of vacuum distillation are made use of on a large scale by gasoline refineries, liquor distilleries, and factories manufacturing solvents. Sublimation is the process of distilling solid volatile substances. The product is termed a sublimate. Many solid substances are purified from their impuri- ties by this process, which is also made use of to obtain a solid substance in the form of a very fine powder. In sublimation the temperature at which the condensation of the vapor takes place largely determines the physical character of the sublimate. There are three kinds of sublimates: Cake, as camphor, corrosive sublimate, etc.; Powder, as calomel, sublimed sulfur, etc.; and crystal, as iodine, naphthalene, etc. Pharmaceutical processes not requiring the use of heat. Comminution is the process of reducing a substance to fine particles. Under this head are grouped various mechanical processes for accomplishing the neces- sary reduction, some of which are: Cutting, slicing, bruising, rasping, grating, chopping, rolling, stamping, grinding, trituration, levigation, elutriation, pul- verizing, etc. The object of all these processes is to facilitate the solution of a substance or of its active principle and to permit of its administration in the form of a fine powder. Those most employed in retail dispensing are tritura- tion, grinding, and pulverization. A few of them will now be described. Trituration is the process of reducing substances to fine particles in a mortar with a pestle. Mortars are usually made of glass, porcelain, or wedgewood and the pestles are made of the same material as the mortar. The substance to be triturated is placed in the mortar and rubbed with the pestle. The motion of the pestle should follow the curve of a spiral, beginning in the center and gradually working outward. This process is employed more than any other in a retail dispensary when it is desired to reduce a substance to fine particles. Levigation is the process of reducing substances to a state of minute division by triturating them after they have been made into a paste with water or other liquid. A shallow mortar with a properly fitting pestle, or a ground-glass slab with a flat-surfaced glass muller is required. When the slab and the muller 618 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY are made of porphyry the process is called porphyrization. The motion given to the muller should closely follow the lines of the figure 8 or of oval loops intersecting each other, the object being to so vary the motion that all particles of the powder are reached. Elutriation is the process of separating coarser from finer particles of insolu- ble substances by suspension in water, and is sometimes called water-sifting. The substance is powdered, mixed into a thin paste with water, and thrown into a vessel containing water. After allowing the heavier particles to subside, the liquid containing the lighter particles is decanted into another vessel, and the fine particles allowed to settle. Later the clear liquid is drawn off. Pre- pared chalk is an example of a substance obtained by elutriation. Pulverization by intervention is the process of reducing substances to powder through the use of a foreign substance from which the powder is subsequently freed by some simple method, such as evaporation. Camphor can be reduced to a fine powder by triturating it in the presence of a few drops of alcohol or chloroform. After a drug has been reduced to a fine state of subdivision it is often necessary to separate the fine from the coarse particles which is accomplished by sifting with a sieve. Sieves are numbered 20, 40, 60, 80, and 100, according to the number of meshes per linear inch of the screen. The degree of fineness of a powder is designated by the number of the finest sieve through which it will pass. A number 80 powder is one that will pass through a number 80 sieve but will not pass through a number 100 sieve. The degree of fineness is also designated by the terms coarse powder (20), moderately coarse powder (40), moderately fine powder (50), fine powder (60), very fine powder (80), etc. The reduction of vegetable drugs to fine particles is necessary to allow the extraction of their soluble principles in making tinctures and fluidextraets. A glance at the IT. S. Pharmacopceial formulas for making tinctures and fluid- extracts will show that the fineness of the powder to be used is always specified. In some cases a coarse powder, sometimes a moderately fine, and again a very fine powder is specified. A vegetable drug having fine cells must be reduced to fine particles in order to break up as many of the cells as possible because the active principles of the drug might be confined within a tough cell wall, and if this wall remained unbroken the active principle might escape extraction. Solution. A solid, liquid, or gaseous substance can be so completely absorbed into, and so homogeneously mixed with, another liquid substance, that it can be said to have disappeared in that liquid substance. This is because the particles of the first substance are so uniformly diffused through the liquid that they do not separate upon standing, cannot be detected even under a high power microscope, and cannot be removed by filtration. When substances are thus combined the result is what is called a true or simple solution, which may be defined as a permanent and complete molecular incorporation of a solid, liquid, or gaseous substance in a liquid substance. The substance incorporated in the liquid is called the solute, and the liquid in which the substance is incorporated is called the solvent. Solutions may be divided into several different classes according to the different ways in which solution is effected or according to the physical states of the components, but in pharmacy the principle concern is with solutions of solids, liquids, and gases in liquids. Two of these classes are simple, in which no change occurs in the chemical structure or identity of the dissolved sub- stance, as when sugar is dissolved in water, and chemical, in which there is a PHARMACY 619 change in the chemical structure or identity of the dissolved substance, as in the making of solution of nitrate of mercury, when red mercuric oxide is dis« solved in a mixture of nitric acid and distilled water and the mercuric oxide changes to mercuric nitrate. In simple solutions the process of evaporation will recover the dissolved substance with its identity unchanged, but evapora- tion of chemical solutions will not yield the original dissolved substance for its identity has been changed. A saturated solution is a solution in which, at a given temperature, the sol- vent has taken up the maximum amount of the solute. In other words, the solvent can dissolve no more of the solute. A saturated solution is usually understood to be made at 25° C., the standard temperature for solubilities prescribed by the U. S. Pharmacopoeia. Practically, saturated solutions are made up at ordinary room temperature. A solution might be saturated with one substance and still be capable of dissolving a large amount of another substance. When a saturated solution is cooled below the temperature at which it is made, precipitation usually occurs; therefore, a saturated solution made during the summer would undergo a certain amount of precipitation if kept until winter, A supersaturated solution is one that contains more of a given substance than it will retain at ordinary temperatitre. A supersaturated solution is made by heating the solvent and dissolving the substance in it while hot. When such a solution cools precipitation of the excess takes place. Solution is aided by agitation, heat, comminution, and by slightly changing the chemical character of the substance to be dissolved. Heat aids solution by keeping the liquid in motion, and by increasing the size of the intennolecular spaces of both the solvent and the solute, allowing an intermingling of the molecules. (See under molecular physics in chapter on Chemistry). The in- crease in the size of the intermolecular spaces accounts for expansion of a substance when it is heated, and for the fact that a hot solvent will dissolve more of a given substance than a cold solvent. Chemical action aids solution by changing the chemical composition of the substance to be dissolved. Quinine sulfate which is normally soluable in 720 parts of water can be made to dissolve in 9 parts of water by addition of a few drops of hydrochloric acid. Iodine which is practically insoluble in water can be made to dissolve freely by the addition of potassium iodide. In these cases the chemical character of the substances is very slightly changed. In other cases chemical action aids solution by producing a complete and permanent change in the character of the substance dissolved. The solubility of a substance is indicated in the U. S. Pharmacopoeia by stating the minimum number of cc of solvent that 1 Gm. of the substance will dissolve in at 25° C. It is also expressed in some cases by the use of such terms as freely soluble, sparingly soluble, soluble, very soluble, etc. Some of the more common solvents used in pharmacy are water, alcohol, diluted alcohol, glycerin, petroleum benzine, liquid petrolatum, benzene, ether, chloroform, diluted acetic acid, fixed oils, volatile oils, and diluted ammonia water. Water dissolves many compounds both organic and inorganic, inorganic salts, alkaloidal salts, gums, etc. It is chemically and therapeutically inactive, and in general has no effect on the substances dissolved in it. One of the objections to its use is the tendency for microscopic plants of the fungus type to grow in it; this is overcome largely by the use of recently boiled distilled water. It is very often mixed with other solvents in the manufacture of 154294°—39 40 620 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY official preparations. It is the solvent used in the preparation of the official waters and liquors. Water has no preservative properties, which is one of its principal disadvantages. Alcohol is, next to water, the most important solvent used in pharmacy. It is frequently used as a solvent mixed with different proportions of water in the preparation of tinctures and fluidextracts. It dissolves many sub- stances that water will not and it possesses preservative properties that give it a decided advantage over water. The principal objection to its use is that even in small quantities it produces its characteristic effect on the system. It dissolves resinous drugs, oils, many organic and inorganic compounds, alka- loids, and many other substances. It is used in making tinctures and fluid- extracts. Glycerin will dissolve many substances that water will, and will precipitate hut few substances from aqueous solution. It mixes well with alcohol or water and is often used with one or both of these solvents. It is an excellent solvent for tannin and phenol. It is used as the solvent in the preparation of the U. S. P. glycerites. Separation of fluids from solids. Some of the processes for separating fluids from solids are lotion, decanta- tion, eolation, filtration, clarification, expression, percolation, etc. Lotion (meaning to wash) is the process of separating soluble matter from a solid by pouring upon the solid a liquid which will dissolve and wash out the soluble portion. This process is usually preceded by filtration or straining, and the substance to be washed is usually what remains on the filter after the excess liquid has drained off. Lotion is made tise of extensively in making chemical analyses of substances. Figure 147.—' ■Decantation from beaker (left) and from precipitating jar (right). (Arny.) Decantation is the process of separating a liquid from a solid by pouring off the liquid after the solid has settled. This is sometimes better effected by use of a syphon. Decantation is a very effective method of washing soluble substances from solids. (Fig. 147.) Colation (straining) is the process of separating a solid from a liquid by pouring the liquid mixture upon a cloth strainer stretched on a frame. The PHARMACY 621 cloth usually is a piece of gauze, muslin, or flannel, depending on the character of the liquid that has to pass through it. This process is employed in strain- ing those liquids that will not pass readily through a filter paper. Filtration is the process of separating liquids from solids with the view of obtaining the liquid in a transparent condition and free from the very finest particles of insoluble matter. Of all the processes made use of in separating solids from liquids filtration is the most important. Filters are made of paper, paper pulp, sand, asbestos, ground glass, charcoal, porous stone, glass wool, etc. Clarification is the process of separating from liquids, without the use of strainers or filters, solid substances which interfere with their transparency. This process is seldom used in pharmacy. It is sometimes substituted for filtration or straining in the case of liquids that will not pass through a strainer, or where straining is slow or difficult. Clarification may be effected by the application of heat, by the addition of water, by the use of albumin, gelatin, or milk, by fermentation, by the use of paper pulp, and by long stand- ing, when the solid substance settles to the bottom of the container and is known as a sediment. This method of clarification is sometimes called sedimentation. Precipitation is the process of separating a solid from its solution by the action of heat, light, or chemical substances. The separated solid is termed a precipitate; the cause of the precipitation the precipitant; and the liquid which remains in the container the supernatant liquid. A precipitate may either rise to the top or sink to the bottom of the liquid from which it is precipitated, according to whether it is heavier or lighter than the liquid. Whereas a sediment is solid matter separated from solution by gravity, being merely suspended instead of dissolved in the solution, a precipitate is solid matter that has been separated from solution. The objects of precipitation are to obtain solid substances in the form of fine powder, to purify substances, and to identify a substance in chemical testing. The physical characteristics of precipitates are described by the words curdy, granular, bulky, flocculent, gelatinous, crystalline, etc. A magma is a thick tenacious precipitate left after the liquid is decanted. The character of precipitates, whether heavy or light, may be controlled by regulating the con- centration and temperature of the two solutions which are poured together to produce the precipitate. Light precipitates are made by mixing cold diluted solutions, and heavy precipitates are made by mixing hot concentrated solutions. Crystallization is the process by which substances are caused to assume cer- tain definite geometric forms called crystals having plane surfaces called faces, edges and angles. The scientific classification of crystals is based on the length, number, and relative position of their axes (plural of the word axis) and in this classification six systems are commonly recognized. In describing crystals the Pharmacopoeia does not always use scientific terms but general terms such as prismatic, laminar, acicular, cubical, etc. Substances that crystallize are known as crystalline and those that do not as amorphous substances. When a substance crystallizes in two or more forms belonging to different systems it is said to be dimorphous, trimorphous, poly- morphous, etc. When different substances crystallize in the same form they are said to be isomorphous. Crystallizable substances always assume their own characteristic form, or some form directly derived from it or related to it. The principal object of crystallization is to obtain a substance in a highly purified form. Crystals are obtained by the following different methods; Fusion and partial cooling; sublimation; deposition from supersaturated solu- tions as they cool; deposition from solutions during evaporation; deposition 622 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY from solutions while a galvanic current is passing through them; precipitation: adding a substance having a strong affinity for water. In pharmacy the use of granular crystals is usually preferred for the reason that they are more readily soluble than are large, perfect crystals. Many substances in the act of crystallizing combine chemically with water, and this water is known as water of crystallization. The amount of water of crystallization that a substance contains is expressed relatively by stating the number of molecules of water (H20) that are loosely combined with one mole- cule of the substance. The formula for monohydrated sodium carbonate is Na2C03.H20, which means that each molecule of contains one molecule of H20; the formula for magnesium sulfate is MgSCh.TELO, which means that each molecule of MgSCX contains seven molecules of H20. When crystalline substances are heated the water of crystallization is driven off and they are then known as exsiccated or anhydrous substances. If an exsiccated salt is dissolved in water and the solution evaporated gently the exsiccated salt will recrystallize with the same amount of water of crystalliza- tion that it originally contained. In determining the molecular weight of a substance, the molecular weight of the water of crystallization is added to the molecular weight of the substance without water. When crystals lose their water of crystallization and form a powder on the mttside they effloresce; crystals that absorb water are said to be hygroscopic, and when they absorb sufficient water to liquefy they are said to deliquesce. The liquid remaining after crystals have formed is known as the mother liquor. Some substances in crystallizing form masses of crystals and in the process mechanically imprison water in the interstices between the crystals. Such imprisoned water is called interstitial water to differentiate it from water of crystallization, and crystals may be freed of it by crushing the mass or gently heating it. It is sometimes necessary to separate crystallizable from noncrystallizable substances and the process of separating them is known as dialysis. The vessel used for this operation is called a dialyzer and has a drum-like head or dia- phragm made of parchment-like membrane at one end. Into this the substances to be separated are placed in the form of a solution and whole is floated on water where the crystallizable substance passes through the drum head into the water below, leaving the noncrystallizable substance behind. In this opera- tion the crystallizable substances are called crystalloids and those which are not crystallizable are called colloids. The object of dialysis is to obtain either the crystallizable or noncrystallizable substance free from the other. Extraction is the process of separating soluble principles from drugs by treating them with a liquid in which the principles are soluble. There are five principal methods of extraction: Maceration and expression, digestion, per- colation, infusion, and decoction. The solvent used in all cases of extraction is called the menstruum. Maceration is the soaking of a drug in the appropriate menstruum at room temperature until the soluble portion of the drug is dissolved. After the drug has soaked for some time, with frequent shaking, the insoluble matter is separated by straining and expression. Expression is the forcible separation of liquids from solids and is accomplished usually by the use of presses which in pharmacy are known as spiral twist, screw, roller, wedge, lever, and hydraulic, according to the mechanical principles involved in their action. This process is preferred to percolation in making strong extracts of vegetable drugs where a long time is required for the liquid to permeate the dried particles, and in PHARMACY 623 the case of those drugs which clog a percolator. Maceration is sometimes aided by suspending the ground drug, tied in a bag, in the upper part of the men- struum. This is known as circulatory maceration. When gentle heat is applied during the process of maceration or when warm water is used the process is then called digestion. Infusion is the process of extracting the water soluble principles from vegetable drugs by pouring hot water on the drug or by treating the drug with cold water for a definite length of time. Cold water should be used when the drug contains a valuable volatile principle, when the active principle is injured by heat, and when the desired principles are readily soluble in water of ordinary temperature. If the mixture of drug and water is boiled to secure the active principles of the drug the process is then called decoction. The last of the methods of extraction is that now to be discussed. Percolation is the process whereby a powder contained in a suitable vessel is deprived of its soluble constituents by the descent of a solvent through it. This process is also known as displacement. The U. S. Pharmacopoeia directs that a substance, in powder, contained in a vessel called a percolator, be sub- jected to the solvent action of successive portions of menstruum in such man- ner that the liquid, as it traverses the powder in its descent to the receiver, shall be charged with the soluble portions and pass from the percolator free from insoluble matter. A percolator is a cylindrical or conical vessel with a porous diaphragm at the bottom, into which the drug in the form of a powder is introduced, and its soluble portions extracted by the descent of the solvent through it. (Fig. 148). The solvent, or menstruum, which is poured on the top of the powder, in passing downward exer- cises its solvent power on the successive layers of the powder until saturated, and is impelled down- ward by the combined force of its own gravity and that of the column of liquid above, minus the capillary force with which the powder tends to retain it. When the menstruum, saturated with the soluble principles of the drug, escapes from the bottom of the percolator it is known as the percolate. It has been stated before that vegetable drugs must be reduced to fine particles in order to break up the walls of the cells within which much of the active principles of the drug is contained. After grinding or otherwise breaking up the vegetable drug the soluble principles are to be found in the fine dust scattered through the powdered drug and in the thoroughly disintegrated particles. In this form but little resistance is offered to the passage of the solvent through the powder and the first portion of the solvent passing through the powder will come in contact with more of the soluble principles than will the later portions. The solvent first takes up the soluble principles released through grinding and powdering and afterward permeates the cells and cell walls to take up any soluble principles remaining in them. Consequently, the percolate first escaping from the percolator is more highly colored and contains more of the soluble principles than the later portions. The process of percolation may be divided into six steps as follows: 1. Comminution or reduction of the drug to the required degree of fineness; 2. Moistening of the drug; 3. Maceration or soaking of the drug either within or without the percolator before pouring on the menstruum; 4. Packing the Figure 148.—Official percola- tor (left) and process of percolation (right). (Rem- ington. ) 624 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY drug in the percolator; 5. Pouring on the menstruum; 6. Regulating the flow of and collecting the percolate. The process of percolation is used in pharmacy in the preparation of tinc- tures, fluidextracts, etc., and it has a great advantage over maceration in ex- tracting the soluble principles of drugs as by percolation every trace of soluble matter can be removed. PHARMACEUTICAL PREPARATIONS OFFICIAL IN THE U. S. PHARMACOPCEIA XI In this section only those pharmaceutical preparations named in the IT. S. Pharmacopoeia XI will be discussed as they are those commonly known as “official”, or “pharmacopoeial”, preparations, the U. S. P. XI directing that the word “official” shall “be considered as synonymous with ‘pharmacopoeial’ In addition to the “official” pharmaceutical preparations herein discussed there are others recognized by the National Formulary and miscellaneous ones not recognized by the U. S. Pharmacopoeia or the National Formulary which are frequently used in the practice of pharmacy. Pharmaceutical preparations manufactured by the processes which have been described in the preceding section are divided into two main classes known as galenical preparations and chemical preparations. Galenical preparations are those in the manufacture of which no chemical action is involved; they are simple solutions or mechanical mixtures. Chemical preparations are those in which chemical changes occur during the process of their manufacture. They are also grouped further in two general classes of liquids and solids according to the nature of the preparation. Liquid preparations are those in which the medicinal substance is contained in various liquid vehicles, and solid preparations are those in which the medicinal substance is incorporated in a solid or semisolid vehicle. Liquid and solid preparations may also he grouped in classes according to the nature of the principal vehicle used in their manufacture, as aqueous, oleaginous, etc., and according to the nature of the preparation, as extracts, pills, etc. Both liquid and solid preparations may be made with maceration and percolation or without maceration and percolation. In addition to these pharmaceutical prepartions there are natural prepara- tions used in pharmacy, some of which are alkaloids, glucosides, and other neutral principles, acids, alkalies, etc. Liquid preparations. Aceta (vinegars) are solutions of the active principles of vegetable drugs in diluted acetic acid. Diluted acetic acid is used as a menstruum because it is a good solvent and also possesses antiseptic properties. Vinegars are a very old class of pharmaceutical preparations but are gradually passing into disuse. There is but one official vinegar in the U. S. P. XI, Acetum scillce; vinegar of squill. Aquae (waters) are aqueous solutions of volatile substances, and are also known as medicated, aromatic, or distilled waters. In the U. S. P. XI are listed Aqua destillata, distilled water, and Aqua destillata sterilisata, sterilized distilled water, neither of which contain anything in solution. The substances used in the preparation of waters may be either solid, liquid, or gaseous, but they are all volatile. Many of the waters are made from volatile oils which are only slightly soluble in water and such waters are spoken of as aromatic waters. They have very little medicinal effect and are used princi- pally as flavored vehicles in which active drugs are administered. Ammonia PHARMACY 625 water differs from the other waters in that it is a powerful caustic and must be handled with care. Four methods are employed in the preparation of waters as they are made from substances that are not readily soluble in water. The methods are: 1. Simple solution in cold water; 2. Filtration with the aid of an absorbent powder; 3. Filtration with the aid of pulped or shredded filter paper; 4. Distillation. For making waters by the process of filtration through an absorbent powder the Pharmacopoeia recommends the use of purified talc. In the preparation of most of the waters official in the Pharmacopoeia it is directed that distilled water be used, and the use of distilled water that has been recently boiled is preferable as it is then free from the microorganisms that produce unsightly growths in waters after they have stood for some time. The term “aromatic waters” refers to those waters made from odorous prin- ciples and which are used chiefly as perfumes and flavorings. After aromatic waters stand for a long time they deteriorate and are unfit for use; therefore they should be made up only in small quantities as required. Fifteen waters are recognized in the U. S. P. XI. Collodia (collodions) are liquid preparations intended for external use having as their base a solution of pyroxylin, or gun-cotton, in a mixture of ether and alcohol. When applied to the skin the ether and alcohol evaporate and leave a thin film of gun-cotton (“new skin”) which acts as a protective. The layer of gun-cotton left after evaporation of the ether and alcohol is brittle and liable to crack when applied to a movable joint. In flexible collodion a small amount of castor oil is added with the result that the film left after evaporation is pliable. Two collodions are official. Decocta (decoctions) are liquid preparations made by boiling vegetable drugs with water for 15 minutes. There are no official decoctions but a general formula for their preparation is provided in the Pharmacopoeia. This formula directs that 50 Gms. of drug, coarsely comminuted, be boiled with sufficient water to make 1,000 cc of decoction. Decoctions spoil quickly and should never be dispensed unless freshly made. Elixiria (elixirs) are aromatic, sweetened, hydro-alcoholic solutions some- times containing active medicinal substances. Aromatic elixir, composed of water, alcohol, and syrup, flavored with compound spirit of orange, is used as the vehicle in preparing most medicated elixirs. Two elixirs are official. Emulsa (emulsions) are liquid preparations in which oily or resinous sub- stances are suspended in water by means of adhesive, mucilaginous, or other viscid matter. They are sometimes classified as natural and prepared emul- sions. A natural emulsion is one which exists ready formed in Nature, of which typical examples are milk, egg yolk, and rubber latex; a prepared emul- sion is one which is made artificially, of which all pharmaceutical emulsions are examples. Oil and water are two liquids of which emulsions may be formed, and according to whether the oil is mixed in the water or the water in the oil, emulsions are known as the oil-in-water type (cod-liver oil emulsion) or the water-in-oil type (Carron oil). Violently shaking oil and water together produces an emulsion for the moment but on standing the oil and water quickly separate because there is nothing present to keep the fine globules of oil from running together and separating from the water. In order to make an emulsion that is stable and will not separate it is therefore necessary to use a third substance known as an emulsifier or emulsifying agent which is a substance that makes it possible 626 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY for one liquid to hold another liquid in suspension without “breaking” or “cracking”, terms used when the particles in an emulsion separate and run together. Most substances which produce foam in water are good emulsifying agents. They may be saponaceous (soapy), mucilaginous (gummy), or albu- minous (white of egg) in character. The most commonly used emulsifying agents are acacia, tragacanth, egg yoke, Irish moss, casein, etc. Casein is obtained from milk, a natural emulsion. Prepared emulsions usually are made by either the Continental or the Eng- lish method. The Continental method, sometimes called the 4-2-1 method because 4 parts of oil, 2 parts of water, and 1 part of emulsifying agent are first mixed to make the nucleus or primary emulsion, produces an emulsion quicker than the English method and is more generally used, as a good emulsion always results if the method is correctly followed. In making an emulsion by the Continental method the first step is to place the oily or resinous substance in a dry mortar, add the emulsifying agent, and rapidly triturate them until intimately mixed. The next step is to add the water all at once and continue to triturate rapidly and vigorously until a thick, creamy emulsion results, which is the nucleus or primary emulsion. The final step is to bring the emulsion up to its final volume and the proper strength by adding water to the nucleus in small portions with constant trituration. Triturating the oily or resinous substance reduces it to a state of very fine subdivision, or in other words breaks it up into very fine particles which are intimately mixed with the emulsifying agent. When the first water is added a mucilage is formed with the emulsifying agent and each fine particle is sur- rounded or enveloped by a thin film of the mucilage which holds them in sus- pension and prevents them from running together again. Four emulsions are official. Fluidextracta (fluidextracts) are liquid preparations of vegetable drugs con- taining alcohol as a solvent or as a preservative, or both, and so made that each 1 cc contains the therapeutic constituents of 1 Gm. of the standard drug which it represents. Fluidextracts resemble tinctures but they are stronger. The solvents used and the methods employed in their preparation are much like those for the preparation of tinctures. Some of the advantages possessed by fluidextracts are permanence, concentration, and uniform relation between the drug and the fluid- extract. They keep well because they are made with a menstruum containing alcohol, and sometimes glycerin, both of which are preservatives. The concen- tration of the active principles of a vegetable drug in a small volume of liquid reduces the volume of the dose and thereby largely avoids the physiological effect of the alcoholic menstruum which is one of the objections to the use of tinctures, especially weak tinctures that are given in large doses. The uniform relation (1 Gm. of the standard drug equaling 1 cc of the fluidextract) existing between the vegetable drug and finished fluidextract simplifies calculations in the preparation of doses. The official fluidextracts are standardized whenever made from a drug that is capable of being assayed either chemically or biologically. They are made by the process of percolation and the menstruum to be used is specified in each case, the rate of flow of the percolate is directed, and the time of maceration is prescribed, so that the medicinally active or important constituents may be completely extracted from the specified quantities of the drug. The Pharma- copoeia provides four general formulas or processes for making fluidextracts which are known as Processes A, B, C, and D. Process A is used for preparing PHARMACY 627 fluidextraets with menstrua of alcohol or with mixtures of alcohol and water by ordinary percolation; Process B is used in preparing fluidextraets, the menstrua for which contain, in addition to alcohol, or a mixture of alcohol and distilled water, definite quantities of other components such as an acid or glycerin, the two menstrua being successively employed; Process C, known as fractional or divided percolation, is used for preparing fluidextraets of drugs whose constituents are injured by heat; and Process D is used for preparing fluidextraets with boiling distilled water as the menstruum, alcohol being added to the concentrated percolate as a preservative. Eleven fluidextraets are official. Glycerita (glycerites) are mixtures or solutions of medicinal substances with glycerin. They can easily be diluted with water without causing precipitation of the substance dissolved in the glycerin. Many substances can be dissolved in greater concentration in water if they are first dissolved in glycerin and the glycerin solution then mixed with water. For example, if it is desired to make a solution of phenol in water of a greater strength than 5 per cent it can be done by making a 50 per cent solution of phenol in glycerin and then diluting that solution to the desired percentage strength. Three glycerites are official, one of which, glycerite of starch, is a semisolid. Infusa (infusions) are liquid preparations made by treating vegetable sub- stances with either hot or cold water. They are seldom used in America and as they spoil quickly should be used the same day they are made or as soon as possible. There are no official infusions but the Pharmacopoeia provides a general formula for their preparation. In making infusions boiling water may be poured over the drug but it should not be subjected to the boiling process. They usually are made by maceration, digestion, percolation, or by diluting concentrated preparations. Linimenta (liniments) are solutions or mixtures of various substances in oily or alcoholic liquids intended for external use by friction and rubbing of the skin. In dispensing liniments the container should always bear a label indi- cating that they are for external use only. Four liniments are official. Liquores (solutions) are aqueous solutions of nonvolatile substances. This group of pharmaceutical preparations usually contains very active medicinal substances and some solutions contain powerful poisons. Generally they are classed as simple or chemical solutions, according to the methods by which they are prepared. Those classed as simple solutions are made by the ordinary process of dissolving the drug in water and without any change in the chemical structure of the dissolved substance; chemical solutions are those in the making of which the chemical structure or identity of the dissolved substance is changed because of chemical reaction at the time solution is effected and the original identity is lost. Twenty-one solutions are official. Magmse (magmas) are aqueous suspensions of the finely subdivided insoluble constituents of inorganic substances. They are closely related to mixtures and consist of soft, thick, tenacious precipitates suspended in water. Two magmas are official, one of which, Magma ferri hydroxidi, is used only as an antidote for arsenic poisoning. It is sometimes known as “the official antidote” for arsenic poisoning and should never be used unless freshly prepared. Mistura (mixtures) are aqueous liquid preparations intended for internal use containing insoluble nonfatty substances. Frequently the insoluble matter is suspended by the aid of viscid or sweet liquids but generally it is in the form of a sediment in the bottom of the container. The insoluble matter usually constitutes the principal part of a mixture and it is therefore important that mixtures be dispensed with a “Shake Well” 628 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY label. Mixtures do not keep well because they usually contain substances that are prone to,fermentation. They differ from emulsions in containing no fat and from liniments in being used internally. There are two official mixtures. Mucilagines (mucilages) are thick aqueous preparations containing viscid substances in solution or suspension. They are made by dissolving gum in water, or by extracting with water the mucilaginous principles of vegetable substances. Mucilages readily undergo fermentation on standing and therefore should always be made fresh when needed; they are used as emollients, as emulsifying agents in making emulsions of oily substances, as pill excipients, and as suspending agents in mixtures. Two mucilages are official and one is made with heat, the other without heat. Oleata (oleates) are solutions of metallic oxides or alkaloids in oleic acid. They are used externally by rubbing them on the skin, through which the active medicinal agent they contain is absorbed and produces its constitutional or local effect. Oleic acid is more readily absorbed than most of the fatty substances used in making ointments. One oleate is official. Oleoresinae (oleoresins) are liquid preparations consisting principally of nat- ural oils and resins extracted from vegetable substances by percolation with acetone, ether, or alcohol. Subsequent distillation and evaporation of the solvent leaves behind the oleoresin. They are the strongest liquid preparations of vegetable drugs produced and can be prepared only from drugs containing volatile oil and resin. Besides the pharmaceutical oleoresins there are natural oleoresins, which are mixtures of volatile oil and resin exuding from plants. Examples of natural oleoresins are turpentine and copaiba. There is but one oleoresin official in the U. S. P. XI. Spiritus (spirits) are alcoholic solutions of volatile substances. They differ from waters only in the solvent used (alcohol instead of water) and a number of volatile substances used in making medicated waters are also used in making spirits. Volatile oils are more soluble in alcohol than in water and the amount of volatile oil in a spirit is therefore much greater than in a water. The average strength of spirits is from 5 to 10 per cent although some are less than 5 per cent and some more than 10 per cent in strength. They are made by: 1. Simple solution; 2. Solution with maceration; 3. Chemical reaction; and 4. Distillation. The spirits made by dissolving volatile oils in alcohol are popularly called “essences”, as Essence of Pepper- mint. There are thirteen official spirits. Syrupus (syrup) is a concentrated solution of sucrose in water or aqueous liquids. When distilled water alone is used in making the solution of sucrose the result is known as simple syrup; when the solution contains soluble medicinal principles the syrup is known as a medicated syrup; and if the solu- tion contains aromatic or pleasantly flavored substances not medicinal in nature the syrup is called a flavored syrup. In the preparation of syrups a high grade of sucrose (sugar) should be used, preferably a grade that meets the requirements of the Pharmacopoeia. Syrup made from inferior grades of sucrose (sugar) is usually colored, does not keep well, and contains impurities. In preserving syrups they should be kept in a cool place in well-filled bottles. A fresh supply of syrup should never be placed in a bottle containing even a trace of old syrup. The bottle should be washed with hot water before refilling. In preparing simple syrup it should be made concentrated because a saturated syrup keeps better than a diluted one. Fourteen syrups are official. Tinotura (tinctures) are alcoholic or hydro-alcoholic solutions of the active principles of animal or vegetable drugs according to the definition given in PHARMACY 629 the U. S. P. XI. They are also defined as alcoholic solutions of nonvolatile substances. Tinctures are different from spirits as they are made from, non- volatile substances, but the tinctures which contain volatile substances ex- tracted from drugs and those which contain iodine are exceptions to the general definitions. Iodine is a volatile, uonmetallic substance or element. Tinctures constitute one of the most important classes of pharmaceutical preparations. Their strength varies, that of the potent, or strong, tinctures being commonly spoken of as 10 per cent, which means that they contain in 100 cc of finished tincture the active principles of 10 Gms. of the standard drug, while others are stronger or weaker than 10 per cent. The IT. S. P. requires that a number of tinctures be assayed in order that the strength may conform to the standard adopted. Two general processes for the making of tinctures are prescribed in the U. S. P. XI. They are Process P, or percolation, and Process M, or macera- tion. The menstrua used are alcohol, diluted alcohol of various strengths, aro- matic spirit of ammonia, ether, ammonia water, or mixtures of alcohol, water, and glycerin. Tincture of iodine is made by the process of solution, the iodine being dissolved in a solution of potassium iodide and alcohol added; tincture of ferric chloride is made by diluting the solution of ferric chloride with alcohol. Tinctures should be kept in a cool place, in tightly stoppered containers, and protected from light. Thirty are official. Solid preparations. Cerata (cerates) are combinations of medicinal substances with fats and waxes intended for external application. They are stiff, ointment-like prep- arations of such consistence that at ordinary temperatures they may be easily spread on cloth or paper, but not soft enough to liquefy and run when applied to the skin. They are called cerates because they contain wax (cera) and are generally made with oil, lard, or petrolatum for a basis, with sufficient wax, paraffin, or spermaceti sometimes being added to raise the melting points of oils and fats. They are made either by fusion or by incorporation and three are official. Emplastra (plasters) are solid preparations intended for external application and containing medicinal substances. Plasters should be of such consistence that they are pliable and will adhere to the skin. Some require the aid of heat in their application. The plaster base or mass which contains the medicinal substance generally is made of lead plaster (a compound of litharge and oil), gum-resins, resin plaster (a compound of resin, lead plaster, and wax), Burgundy pitch, isinglass, and India rubber, or combinations of these substances. The plaster mass is spread upon a backing of muslin, paper, cotton cloth, etc., of suitable size and shape. Common adhesive plaster contains no medicinal substance and is a mixture of rubber, resins, and waxes with one or more fillers of an absorbent powder as zinc oxide, orris root, starch, etc. Most plasters today are machine made and their manufacture is seldom called for in the practice of pharmacy. Four are official. Extracta (extracts) are solid or semisolid preparations containing the soluble and active principles of vegetable and animal drugs. They are obtained by extracting the soluble and active principles of those drugs with appropriate menstrua and evaporating the percolates to the proper consistency. According to their consistency extracts are divided into two classes: Soft, plastic masses, 630 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY known as pilular extracts, and dry powders, known as powdered extracts. The menstrua employed in making extracts vary, alcohol, distilled water, alcohol with distilled water, alcohol with ammonia, alcohol with an acid, and alcohol with glycerin all being used. Extracts contain the active constituents of drugs in a concentrated, uniform, and permanent condition. Those made from alkaloidal drugs are required by the Pharmacopoeia to be standardized as to strength and assay processes are prescribed for this purpose. After the menstruum has been evaporated off a portion of the extract is assayed and the remainder, as determined from the strength shown by the assay, is adjusted to standard strength. In the cases of those extracts not required to be assayed the finished extract is adjusted so that its weight bears a uniform relation to the amount of the drug that was percolated in making the extract. In the finished extract of cascara sagrada 1 gram must be equal to 3 grams of the powdered cascara bark used in the manufacture, because the U. S. P. directs that 900 Gms. of cascara sagrada bark, in fine powder, be exhausted by percolation, the percolate evapo- rated to dryness, reduced to fine powder, weighed, and enough diluent added to make 300 Gms. of finished extract. The diluent is the substance used to adjust the finished extract as necessary to meet the requirements of the Phar- macopoeia. Glucose is directed as the diluent for pilular extracts and starch for powdered extracts but the use of others is permitted. Pillular extracts are soft solids intended for use in making ointments, pills, suppositories, etc. In their preparation the U. S. P. directs that they be diluted, when necessary, with glucose in order to reduce them to the standard strength. Soft extracts should be kept in a cool place, away from light, and in well closed containers to prevent evaporation. If the containers are left open they become hard and dry. Extracts vary slightly in their strength from time to time due to loss of moisture. Powdered extracts are dry fine powders. They are made like pillular ex- tracts except the drying process is carried farther in order to reduce them to a powdered condition. The drying must be carefully done at a low tempera- ture to avoid injury by heat. After they have been dried and powdered they are weighed (assayed in the case of alkaloidal drugs) and diluted as required to bring them to standard strength. Powdered extracts are easier to dispense than pillular extracts because they do not stick to the containers, they can be more accurately weighed, and they are more constant in their strength than pillular extracts. They should be preserved in well closed containers in a dry place. In contact with moist air they absorb mioisture and become sticky. Twelve extracts are official. Massae (masses) are soft, solid preparations composed of an active medicinal substance mixed with excipients to form a mass resembling a pill mass. They are used in making pills and two are official. Pilulae (pills) are small, solid bodies of a round, ovoid, or lenticular shape, usually weighing from 1 to 5 grains. They contain medicinal matter and are intended to be swallowed whole. A holtis is a very large pill and a granule is a very small pill. There are certain advantages in administering medicines in pill form as they can be swallowed without mastication, they are adapted for the administration of heavy metallic substances which cannot readily be suspended in liquids, the action of the medicine is slow and is even retarded in some cases until the pill reaches the lower bowel, being in compact form they are easily swallowed, and when coated they are tasteless. Occasionally pills have to be made by hand and the process of pillmaking consists roughly of three stages, first, making the pill mass, second, dividing PHARMACY 631 the pill mass, and third, rolling the pill. A pill mass should be sufficiently ad- hesive to permit rolling of it without falling in pieces; it should be firm enough to retain its shape when rolled and yet not so soft that the finished pills will flatten during the process of drying; it should be plastic enough to be easily rolled; and most important of all, it should be sufficiently soluble in the juices of the intestinal tract to disintegrate and allow1 the active ingredients to escape and exert their medicinal effect. Excipients are agents added to the contents of a pill to facilitate its being made into a suitable mass. There are four classes of excipients: Those which are intended to develop adhesiveness and hence act as solvents, as water, alco- hol, diluted alcohol, glycerin, and mixtures of water and glycerin; those which are intended to impart adhesiveness, as glucose, syrup, honey, mucilage of acacia, syrup of acacia, mucilage of tragacanth, glycerite of starch, acacia with glucose or honey, tragacanth with glycerin, soap with water, soap with diluted alcohol, extract of malt, confection of rose, etc.; those which are in- tended to act simply as absorbents of excessive moisture, and, in a few cases to impart adhesiveness to the mass at the same time, as licorice, powdered orris root, powdered tragacanth, powdered elm bark, powdered marshmallow, starch, etc. After the pill mass is finished it is rolled out and cut into small pieces. Each one of these pieces represents one pill, and it is finished by rolling it between the thumb and fingers, or in the palm of the hand. To prevent them from adhering together, or from sticking to the fingers while rolling them, they may be dusted lightly with any one of the following powders: Rice flour, pow- dered licorice root, powdered althaea, talcum, lycopodium, or magnesium carbonate. Two pills are official in the U. S. Pharmacopoeia. Pulveres (powders) are combinations of solid drugs in a finely divided state. They may be for internal use or for external application. There are four official powders, all of which are known as compound powders and are for internal use. Powders intended for external application are known as dusting powders, healing powders, etc. Besides the Pharmacopceial and the National Formulary powders, physicians frequently prescribe other drugs in powder form; these may be composed of one or more active ingredients, or they may be composed of active ingredients mixed with an inert diluent (sugar of milk) to give bulk to the powder. The official powders are usually made by rubbing the ingredients together in a mortar until a thorough mixture is obtained, the ingredients being previously reduced to a fine state of subdivision. Some substances have a tendency to cake when rubbed in a mortar, and these should be mixed on a pill tile. This caking is due to the presence of moisture, and to the fine state of subdivision of the powder. Dusting powders and granular effervescent powders should not be triturated in a mortar because of this caking. Dusting powders should always be sifted after they are mixed. Powders which contain strong drugs must of necessity be very intimately mixed in order to insure that an overdose is not contained in any one of the powders. In order to mix one or more strong drugs intimately with other parts of the powder the following rule should be followed: Mix the strongest drug with an equal weight of the next most active drug, and after they are intimately mixed incorporate the remainder of the weaker drug, and then gradually add to this mixture the next weaker drug, etc., until all the ingredients are incorporated. Resinae (resins) are solid preparations consisting principally of the resinous principles from vegetable drugs. They are soluble in alcohol but are insoluble 632 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY in water and are known as natural resins, natural plant exudations, and prepared resins, those obtained by pharmaceutical processes. Prepared resins usually are made by taking the alcoholic extracts of vegetable drugs obtained by percolation and concentrated by evaporation and pouring them into water or acidulated water when the resinous principles are precipitated. These are then collected, washed, and dried. Resins may also be obtained by distilling natural oleoresins, the volatile oils passing over and leaving behind the resin. Although prepared by the process of extraction as are extracts, resins differ from extracts by containing only those plant principles that are soluble in alcohol and insoluble in water. Two resins are official. Suppositoria (suppositories) are solid bodies intended for introduction into different orifices of the human body to produce medicinal action. They are of various weights and shapes and melt or soften at body temperature. The vehicles usually employed to carry the medicinal substances are oil of theobroma, glycerinated gelatin, or sodium stearate. In the preparation of suppositories it is important that the medicinal sub- stance be equally distributed throughout the vehicle. This distribution may be made by rubbing the medicinal substance with the vehicle, or by fusion of the vehicle and incorporation of the medicine with the melted vehicle followed by chilling of the fused mixture in molds. Suppositories are usually prepared by methods known as “hand made or rolled”, “molded”, and “machine made or pressed”. Suppositories should be of such consistency as to retain their shape until inserted and then quickly melt. Oil of theobroma (cocoa butter) is the ideal vehicle or base for suppositories because it melts at a temperature slightly below that of the body but remains solid at ordinary temperatures. It is also a bland, nonirritating oil. After suppositories have been made they should be kept in a cool place. Rectal suppositories should be cone shaped, and if oil of theobroma is used as the vehicle they should weigh about 2 Gms. Urethral suppositories should be pencil shaped and with a rounded point at one end. When 7 centimeters (2y2 inches) long they should weigh 2 Gms., and when 14 centimeters (5 inches) long they should weigh about 4 Gms., if made with glycerinated gelatin as the vehicle. If made with oil of theobroma as the vehicle they should weigh one-half the above amounts. Vaginal sup- positories should be ovoid or globular in shape and weigh about 4 Gms. if made with oil of theobroma and 10 Gms. if made with glycerinated gelatin. Only one suppository is official. Tabellae (tablets) are solid, small, flattened masses of medicinal powders. They are divided into several classes according to the method of manufacture or the use for which they are intended. Among these classes are the tablet triturate, the compressed tablet, and the hypodermic tablet. The general pro- cedure in making tablets is to first grind, thoroughly mix, and sift the ingredients, next granulate the mixed materials by moistening with a suitable liquid containing a “binder” and passing through a very coarse screen, and then dry the coarse granules. After drying the coarse granules they are reduced to the proper size and the material pressed into the proper size and shape. (For full information concerning tablet making refer to a standard textbook on the Practice of Pharmacy.) Three tablets are official, two of them being the “poison” tablets of mercuric chloride which have a distinctive color, not white, and an angular or irregular shape. Triturationes (triturations) are a class of powders having a definite relation between the active medicinal ingredient and the diluent. This relation is one PHARMACY 633 part of the medicinal substance and nine parts of diluent. They are made by adding to the substance, previously reduced to a moderately fine powder if necessary, an equal amount of the diluent, mixing well by means of a spatula, and triturating the powders together in a mortar. The remainder of the dilu- ent is added in portions until the whole is added, triturating after each portion is added, and continuing the trituration until a fine powder is obtained. Sugar of milk (lactose) is prescribed as the diluent, largely because its hardness helps to insure a fine comminution of the medicinal substance. Triturations are excellent forms for the administration of powerful alkaloids. Only the general formula for triturations is official in the Pharmacopoeia. Unguenta (ointments) are semisolid preparations containing medicinal sub- stances blended with fatty matter of sufficient softness to permit their being applied to the skin by inunction. All official ointments are made either by fusion or incorporation; one ointment recognized in the National Formulary, ointment of mercuric nitrate (citrine ointment), is made by chemical reaction. When made by fusion the fatty substances are liquefied by the aid of heat and the medicinal substance incorporated while the fats are liquid or after solidifica- tion ; when made by incorporation the medicinal substance is rubbed up with the solid fatty matter, either in a mortar or on an ointment slab. In making ointments by fusion ingredients having high melting points should be melted before those having a lower melting point as the high heat necessary to melt the former may be injurious to the latter. Ointments made by fusion should be stirred while cooling, because the ingredients having high melting points usually will solidify first, resulting in a granular ointment. If the medicinal substance used is a powder it should be brought to ths finest possible state of subdivision before incorporating it with the ointment base. According to their therapeutic use, ointments may be classified as non- absorbable, those which act as protectives and produce their medicinal effects on the epidermis or outer skin; emollient, those which soften the epidermis and carry their medicinal effects into the derma or true skin; and absorbable, those which penetrate the skin and enter the general circulation producing systemic or constitutional medicinal effects. In order that these therapeutic effects of ointments may be obtained the bases used in the different classes of ointments vary and must be suitable for the purpose intended. An ointment base should not be rancid, not only because of the peculiarly disagreeable odor but because the volatile fatty acids released when rancidity develops are frequently irritating and may cause chemical reaction. Petro- latum is a good ointment base for almost any purpose except when absorption is desired. Being practically nonabsorbable it is an excellent base for oint- ments used in treating skin diseases. Hydrous wool fat is a good ointment base, is quite absorbable, perhaps because of the water it contains, and is used especially in making ointments containing liquids which are not miscible with the prescribed base. The U. S. Pharmacopoeia allows as much as 30 per cent of water in the official hydrous wool fat, and the presence of that amount of water gives it the proper consistency for use as an ointment base. Anhy- drous wool fat is very tough and sticky and for making ointments con- taining a large amount of water or other liquid its use is preferable to the hydrous wool fat. Yellow wax is better for an ointment base than white, or bleached, wax, because in the process of bleaching the yellow wax a change takes place which makes the white wax more likely to become ran- cid. The official glycerite of starch is sometimes directed to be used as the vehicle for ointments under the name of plasma or plasma (jlycerini because 634 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY it is not greasy, can be washed off without difficulty, and never becomes rancid. In making ointment of boric acid it is stirred until congealed, as boric acid is not soluble in petrolatum and is held mechanically. Glycerin is used in tannic-acid ointment to dissolve the acid and make it more effective. Metal spatulas should not be used in making tannic-acid oint- ment, as it attacks the iron, forming tannate of iron, resulting in a darkened ointment. If the spatula first is smeared with the fatty substance, there is little danger. In making cold cream (ointment of rose water) rose water is used instead of oil of roses to perfume it, as the water makes it softer and more creamy. Borax is used in cold cream to give a whiter and more creamy preparation. Water is warmed in making cold cream, because if not warmed it will chill the melted base and make it lumpy or granular. Many cold creams are made with paraffin and liquid petrolatum, as it is a cheaper base and one that does not become rancid. In making belladonna ointment the extract is rubbed with diluted alcohol to thoroughly soften the extract so as to make a homogeneous mixture. Wool fat then is used to take up the liquid. Oleate of mercury is used in making mercurial ointment because it will hold mercury in a microscopic state of subdivision. Mercurial ointment should be kept in a cool place, as the mercury separates out when warmed. Metal spatulas should not be used in its making. Lanolin is better for making yellow oxide of mercury ointment than the simple ointment, as the mercury oxide is not reduced readily. Potassium iodide is used in iodine ointment, as iodine cannot be reduced to an impalpable powder, but is very soluble in a glycerin solution of potassium iodide, and this solution can be mixed intimately with the base. Glycerin is used in iodine ointment to dissolve the potassium iodide. Water is objectionable because it evaporates and the iodide is left in gritty crystals. PRESCRIPTIONS The preparation and dispensing of medicines intended to be compounded ex- temporaneously or as the occasion or the physician’s needs may require is termed magistral pharmacy. Under this head is placed the filling of prescriptions. A prescription is a formula which a physician writes, specifying the sub- stances he intends to have administered to a patient. It is written in the Latin language because that is the official language of science, is understood throughout the world, and, being a “dead” language, is not subject to change. It is sometimes necessary and always advisable that a patient should not know the names and properties of the medicinal agents administered and this is usually possible when Latin is used. The parts of a prescription are: 1. The name of the patient and the date; 2. The superscription, or heading, indicated by the symbol “It”, standing for the Latin word “Recipe” (take thou) ; 3. The inscription, or the names and quantities of the ingredients (the base, the adjuvant, the corrective, and the vehicle) to be compounded; 4. The subscription, or the directions to the pharma- cist or compounder; 5. The signa (mark) or transcription, or the directions to the patient; 6. The name or initial of the physician. PHARMACY 635 B For: John Jones 3/15/23 Sodii bromidi 16 Gm. ( 5iv) Antipyrinae 8 Gm. ( 3 ii) Liquor acidi arsenosi 4 cc (f3 i) Aquae menthae piperitae—q. s. ad 120 ec (f 5iv) Misce et signa: One teaspoonful in water three times daily after meals. Richard Doe, M. D. Model Prescription Before filling a prescription the compounder should read it carefully to judge the safety of the doses of the different ingredients and their compatibility. In law, the pharmacist as well as the physician, is held responsible in case of an overdose, and suit for damages is much more likely to be brought against the pharmacist than the physician. The words “use as directed’’ should be avoided by the preseriber as the patient is generally in a more or less nervous condition and likely to forget the details; then, too, having the directions on the prescription makes another safeguard in that pharmacists can detect an error more readily if one is present. Upon the dose depends the safety. In filling prescriptions requiring the mixture of an insoluble substance with a liquid, it is preferable to rub it in a mortar with a small amount of liquid, because if the solid is put simply into a bottle and shaken the substance may “lump” and require time and agitation in order to get it mixed. This is particularly true with calomel, magnesia, sulfur, or a vegetable drug. The employment of abbreviations in prescription writing is universal but great care must be taken to avoid abbreviations that might lead to the use of unintended substances and the death of the patient. Some titles of medicinal substances should never be abbreviated. Following is a table of abbreviations of the principal Latin words used in pharmacy with their contraction and meaning; Term or phrase Contraction Meaning Ad Ad To, up to. Adde, addantur, addentum, addendo-- Add Add, let them be added, to be added, by adding. At pleasure. White. Ad lib Alb Every other hour. Of each. a a, A Before eating, before meals. Boiling water. Common water. Aq. comm Hot water. Well. Twice. Bis in d., B. i. d-_ Twice a day. Let him (or her) take. Paper. Chart - Food. Cochlear or cochleare, Cochleatim Coch., CochleaC __ Coch. amp . A spoonful, by spoonfuls. A tablespoonful. A large spoonful (about half an ounce). Coch. mag- - A dessertspoonful (about 2 fiuidrams). A teaspoonful (about 1 fluidram). Strain. CoL.-. A nose wash. Collut A mouth wash. Collyr., Col An eye wash. Cong... - A gallon. Against. Cort The bark. Cum C With. 154294°—39 41 636 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Term or phrase Contraction Meaning Dividatur in partes aequales D. in p. seq... ... Let it be divided into equal parts. The same. Of the same. And. Make, let it he made, let them he made. Let 12 papers be made. Let 12 pills be made. Let 12 powders be made. Let it be made according to the rules of art. Let a solution be made. Filter (thou). Yellow. A gargle. A drop. By drops. The same. Mix. Not. Do not repeat. A pint. Equal parts. After eating. Occasionally. A powder. As much as is sufficient. According to art, according to nature. A half. Mark thou. Dissolve. Above. Three times a day. The last ordered. An ounce. As directed. Ejusd.. . Et - - Fac., Fiat., Fiant.. .. Fiant chartulse xii Fiantpilulsexii ... Fiant pulveres xii Fiat secundum artis regulas F„ Ft Ft. chart, xii Ft. pil.xii .. Ft. pulv. xii F. S. A. R Ft. solut .. Filtra Flav .... Gtt . M Nonrepetatur . Non rep.. . ... O P.r.n... Quantum sufflciat, Quantum satis .. . Secundum artem, Secundum naturam. Q. S S. A.,S.N Ss Sig., S T. i. d Ultimo (or ultima) praescriptus Ult. praesc ... Ut Diet INCOMPATIBILITY Incompatibility is a term used in Pharmacy to describe conditions in which drugs used in pharmaceutical mixtures will not combine, produce new com- pounds, or are therapeutically opposed. These conditions are known as pharma- ceutical, chemical, and therapeutic incompatibility. Chemical incompatibility is chemical action resulting in the decomposition of one or more of the ingredients entering into the prescription. It may result in precipitation, production of a gas, in a change in color, or in explosive or poisonous compounds, and is sometimes intentional. Examples: Alkaloids will be precipitated from their solution by tannic acid, alkalies, carbonates, iodine or iodides, phosphates, boric acid, and borates. Explosive compounds will result from mixing powerful oxidizing agents with others which are readily oxidiza- ble, such as nitric or nitrohydrochloric acids, potassium chlorate, or potassium permanganate with glycerin, sugar, alcohol, oils, ethers, tannin, sulfur, sulfides, phosphorus, and hypophosphites. Glucosides are decomposed with substances containing emulsin. Iron salts with tannic acid or drugs containing tannin produce inky mixtures. Pharmaceutical incompatibility (also known as physical incompatibility) is the condition arising from attempting the mixture of pharmaceutical prepara- tions or ingredients which are physically repellent to each other and results in the physical dissociation of one or more constituents, but without chemical action. Examples: Tincture of chloride of iron added to syrup of acacia will gelatinize; fluidextracts diluted with liquids differing from those used in the fluidextracts cause the gum, albumin, resin, or mucilage to separate. Water is the solvent for albuminous, gelatinous, gummy, and saccharine bodies and for a large number of inorganic salts, while alcohol is the solvent for volatile oils and resins, gum resins, resinoids, balsams, and all drugs containing these sub- PHARMACY 637 stances as their active principles. The solvent power of either alcohol or water for the particular substance decreases in proportion to the amount of one added to the other. Therapeutic incompatibility occurs when two agents antagonistic to each other in their action in the human system are given together. Examples: Bella- donna in any form with physostigmine; a solution of bromide of potash with strychnine; opium with caffeine. In many cases physiological antagonists intentionally are given together so that one will act as a guard against the excessive action of the other, as the use of morphine with atropine. THE HARRISON NARCOTIC LAW The Harrison narcotic law, enacted by the United States Congress December 17, 1914, provides that on or after March 1, 1915, every person who imports, manufactures, produces, compounds, sells, deals in, dispenses, or gives away opium and coca leaves or any compound, manufacture, salt, derivative, or preparation thereof, shall register with the collector of internal revenue of his district his name or style, place of business, and place or places where such busi- ness is carried on. The provisions of this act are not construed to apply to the sale, distribution, giving away, dispensing, or possession of preparations and remedies which do not contain more than 2 grains of opium, or more than one-fourth of a grain of morphine, one-eighth of a grain of heroin, or more than 1 grain of codeine, or any salt or derivative of any of them in 1 fluid- ounce, or, if a solid or semisolid preparation, in 1 avoirdupois ounce, or to liniments, ointments, or other preparations which are prepared for external use only, except liniments, ointments, and other preparations which contain cocaine, * * * etc., provided that such preparations are manufactured, sold, distributed, given away, dispensed, or possessed as medicines and not for the purpose of evading the intentions and provisions of this act. A Federal law was later passed which prohibits the importation of heroin and of opium for the manufacture of heroin. Paragraph 736, Manual of the Medical Department, U. S. Navy, concerns the prescription of narcotic drugs. GENERAL PRECAUTIONS IN REGARD TO DISPENSING In filling prescriptions for eye solutions the greatest care should be taken not only in accurately weighing and measuring the amounts called for, but also in maintaining scrupulous cleanliness. See that all containers and utensils are absolutely clean. All eye solutions and eye washes should be filtered through a high grade of filter paper, and distilled water only should be used in making them. These precautions also apply in making solutions for hypodermic injec- tion, such as procaine and cocaine solutions. Be careful when’giving out medicine that the correct drug in correct dosage is being given. Before putting any medicine in the eye or injecting any solu- tion into the uretha, recti ,n, or other body opening one should be sure that the solution is of the proper strength and temperature. Care should also be exer- cised as to ointments and medicaments for application to the skin that they are of the right strength. Nothing so reflects on the Medical Department, and on the individual hospital corpsman who has made the mistake, as an error in which a patient seeking assistance has been made worse or seriously or fatally injured by a poisonous dose of a drug. The greatest care therefore should be exercised in the preparation and giving out of all medication. 638 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY It is also desirable to display an appropriate warning sign in red over the prescription counter to further draw attention to the danger of preparing and dispensing poisonous doses of any drug. HINTS IN PRACTICAL PHARMACY PRESCRIPTIONS 1. Read the prescription carefully, noting the quantity of each ingredient. 2. Do not hesitate to ask if in doubt about the name of a certain drug, proper weight, or dose. 3. Check the weight of each ingredient. 4. Make certain that the balance is in balance. 5. Check off with pencil the name of each ingredient on the prescription in the process of compounding. 6. Do not weigh the ingredients on the bare scale pan. Always place a piece of pan-paper on each pan and again balance the balance. 7. After the prescription has been compounded make such notes on it as may be necessary so there will be no likelihood of the renewed prescription differing from the original. 8. Request the medical officer to initial any change in the prescription he may have ordered. 9. Reduce to a fine powder all crystalline salts before admixture. 10. Do not strain out any insoluble medicinal substance unless directed by the medical officer. 11. If the prescription contains any insoluble matter, dispense it with a “shake” label. 12. All hypodermic solutions and eye lotions should be filtered. 13. Clear solutions containing “specks” or accidental impurities should be strained through absorbent cotton. 14. In making dusting powTders pass the material through a No. 80 sieve to insure greater uniformity and fineness. 15. In folding powders avoid having any medicinal substance in the folds of the powder paper. PILLS 16. Use a white excipient in making light pills with corn starch or rice powder as a dusting powder. 17. When making dark pills use a dark excipient such as extract of gentian, with lycopodium as a dusting powder. Note.—When making pills containing oxidizable substances such as potas- sium permanganate, silver nitrate, etc., use cocoa butter as an excipient. 18. The maximum weight of the average pill should not exceed 5 grains. 19. Always use the proper utensils in making pills—shallow mortar, flat pestle, stiff broad spatula, glass tile, pill machine and finisher (if available.) 20. A whiter emulsion is obtained when acacia is used as an emulsifying agent. 21. Tragacanth is preferred as an emulsifying agent in emulsions containing alcoholic mixtures. 22. Do not use tincture of soap bark as an emulsifying agent as it exerts some physiological action. 23. Solution of potash or soda must not be used. The finished product will be a soap and not an emulsion. EMULSIONS 639 PHARMACY 24. The mortar must be perfectly dry when making an emulsion. 25. Add water very slowly to the “primary emulsion,” or nucleus, to prevent cracking. 26. Wedgwood mortars are preferred in making emulsions. 27. Use the “Bottle” method in making emulsions containing volatile oils. 28. Remember the proportions in making an emulsion of a fixed oil by the Con- tinental method: Oil, 4 parts; water, 2 parts; gum, 1 part. 29. In making the nucleus of an emulsion of a volatile oil the proportions are: Oil, 4 parts; water, 2 parts; gum, 1 part. OINTMENTS 30. Do not use a rancid ointment base. 31. Use anhydrous wool fat in making ointment containing a large amount of water or other fluid. 32. Use benzoinated lard in making ointments to retard rancidity. 33. The medicinal agents must first be mixed with a small portion of the base to insure a smooth finished product. 34. Ointments intended for application to the eyes should be mixed in a glass mortar. 35. Never use the fusion method in making sulfur ointment—the sulfur is precipitated. Avoid using too much heat in making any ointment. 36. In making boric-acid ointment stir until congealed, because the boric acid is held in the petrolatum mechanically. 37. Do not use an iron spatula in making iodine or tannic-acid ointments. 38. Use warm water in making cold cream to prevent a lumpy or granular product. 39. Diluted alcohol should be used in making belladonna ointment to soften the extract. 40. Reduce the iodine to an impalpable powder with the aid of a glycerin solution of potassium iodide in making iodine ointment. 41. Use water to dissolve the potassium iodide in making the ointment of this salt. CAPSULES 42. It is desirable to seal hard capsules containing liquid medicine. 43. Sealing hard capsules is accomplished by pressing the cap upon a small piece of absorbent cotton saturated in hot water or diluted alcohol. 44. Before dispensing always rub the filled capsule between the folds of a towel or piece of gauze to remove any powder clinging to the outside. 45. In filling capsules, fill the body of the capsule and not the cap. GENERAL HINTS 46. Waxed or parchment paper should be used when dispensing medicine that is hygroscopic or is likely to change in the air. 47. Do not triturate potassium chlorate with organic matter. There is danger of an explosion. 48. The only way camphor can be powdered is by addition of a small quantity of alcohol. 49. Always put the tartaric acid of the Seidlitz powder in the white paper to prevent the acid from becoming colored. 50. Keep tincture of iron in a colored bottle and protected from light, as light reduces the iron. 640 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 51. Use blue-colored bottles for poisonous liquids or liquids intended for external use. 52. Every medicinal substance sent out from the dispensary must have a neat and distinct label upon it. 53. It is good pharmaceutical practice always to attach a poison label when dispensing medicines containing poisons. 54. Attach “local use” labels to eye lotions and mouth washes and “external use” labels to liniments. 55. Never dispense an emulsion or mixture containing insoluble material without a “shake” label. 56. Always remember the five cardinal points in labeling a prescription— 1. Patient’s name and rating; 2. Date; 3. Number; 4. Directions; and 5. Medical officer’s signature. 57. In refilling prescriptions thoroughly clean the soiled containers. Affix a new1 label and in case of a bottle use a new cork. 58. Two hospital corpsmen should check prescriptions when possible. 59. If the man who compounds a prescription is required to check his own work, he should keep on the counter all the containers from which he takes the ingredients until the prescription is compounded. Then proceed to check off each item and its quantity. 60. If in doubt as to just what was used or the quantity used, throw away the entire prescription and start again. It is better to lose some material than to dispense the wrong medicine. 61. Paste the label evenly on the front of the bottle, a little above the center. All bottles, even round ones, have a front. Avoid an excess of paste. To smooth the label on the bottle place a piece of clean paper over it and rub. To make labels stick on tin, coat the tin first with a thin layer of tincture of benzoin (or any resinous substance) and let dry. Then apply paste and, lastly, the label. 62. Be neat in dispensing. Be sure that utensils and bottles are clean, corks are whole, and that packages are wrapped neatly. 63. Do not forget the proper cleaning of a mortar or graduate which has been used with oil or ointment; the excess may be easily removed by wiping out with sawdust or newspaper. 64. A handy twine holder is a small funnel suspended in a convenient place. Place the ball of twine inside and run the end of the string through the funnel end. PHARMACY 641 Solution Table Showing the Quantity of Drug in Grains to Use in Preparing Aqueous Solutions op Various Strengths Apothecaries measure. (1 FLUIDOUNCE WATER WEIGHS 456 GRAINS) Fluidounces of solution 1 1 1 1 1 1 500 A per cent 1 per cent 2 per cent 3 per cent 4 per cent 5 per cent 10 per cent 20 per cent 25 per cent 50 per cent 5,000 4,000 3,000 2,000 1,000 'A 0.0456 0.057 0.0760 0.114 0.228 0.456 1.14 2. 28 4.56 6.84 9.12 11.4 22.8 45.6 57 114 1 .0912 .114 .1520 .228 .456 .912 2.28 4.56 9.12 13.68 18.24 22.8 45.6 91.2 114 228 2 .1824 .228 .304 .456 .912 1.824 4. 56 9.12 18.24 27. 36 36. 48 45.6 91.2 182.4 228 456 3 .2736 .342 .456 .684 1.368 2.736 6, 84 13.68 27. 36 41.04 54. 72 68.4 136.8 273.6 342 684 4 .3648 .456 .608 .912 1.824 3. 648 9.12 18. 24 36.48 54. 73 72. 96 91.2 182.4 364.8 456 912 6 .5472 .684 .912 1.368 2.736 5. 472 13.68 27. 36 54. 72 82.08 109. 44 136. 8 • 273.6 547.2 684 1,368 8 .7296 .912 1.216 1.824 3.648 7.296 18.24 36.48 72.96 109. 44 145. 92 182.4 364.8 729.6 912 1,824 12 1.0944 1.368 1.824 2.736 5.472 10. 944 27. 36 54. 72 109. 44 164.16 218. 88 273.6 547,2 1,094. 4 1,368 2,736 16 1.4592 1.824 2.432 3.648 7.296 14. 592 36.48 72.96 145.92 218.88 291.84 364.8 729.6 1,459. 2 1,824 3,648 Solution Table Showing the Quantity op Drug in Grams to Use in Preparing Aqueous Solutions of Various Strengths Metric measure Cubic centimeters of solution 1 1 1 1 1 1 500 H per cent 1 per cent 2 per cent 3 per cent 4 per cent 5 per cent 10 per cent 20 per cent 25 per cent 50 per cent 5,000 4,000 3,000 2,000 1,000 10 0.002 0.0025 0.0033 0.005 0.01 0. 02 0 05 0 1 0 2 0 3 0 4 0 5 1 2 2 5 5 25 .005 . 00625 .0083 .0125 .025 .05 . 125 . 25 . 5 75 1 1 25 2. 5 5 6. 25 12. 5 50 .01 .0125 .0167 .025 .05 . 1 .25 .6 i 1.5 2 2.5 5 10 12.5 25 75 .015 .01875 .025 .0375 .075 . 150 .375 .75 1.5 2.25 3 3. 75 7.5 15 18.75 37.5 100 .02 .025 .033 .05 . 1 .2 .5 1 2 3 4 5 10 20 25 50 200 .04 .05 .067 .1 .2 .4 1 2 4 6 8 10 20 40 50 100 300 .06 .075 .10 .15 .3 .6 1.5 3 6 9 12 15 30 60 75 150 400 .08 . 1 .133 .2 .4 .8 2 4 8 12 16 20 40 80 100 200 500 .1 .125 .167 .25 .5 1 2.5 5 10 15 20 25 50 100 125 250 CHAPTER IX CHEMISTRY GENERAL INTRODUCTION Man lives in a world of material, and his body is of a material nature. This material occurs in an infinite variety of forms and is generally spoken of as matter. On the basis of the natural physical form of its occurrence matter is classed as solid, liquid, or gaseous, and on the basis of its structure it is classed as organic and inorganic. Animal and plant forms of matter are vitalized by a force called life and are endowed with the power to grow, to assimilate other matter, to reproduce their kind, and to react to environmental stimuli. Such matter is classed as organic or living and a clear understanding of the differentiation between organic and inorganic forms of matter is essential to a proper appreciation of the science of chemistry. Plant life, through the action of sunlight on chlorophyll, has the exclusive power to extract carbon from the air and to change and combine it in the complex forms needed by the plant structure. This is the origin of organic matter. Plant organic matter may decompose with liberation of the carbon contained in it, may be preserved as inanimate organic matter, of which coal is an example, or it may be assimilated by some form of animal life and become animal tissue. This animal-tissue carbon is subject in turn to the same fate, and eventually becomes available for the support of plant life. An aquarium is a familiar exairiple of the fundamental part carbon plays in organic life. When the plant life and fish in the aquarium are properly balanced in quantity of each, the aquarium can be sealed off from the outside air without suffocating either form of life. The fish produce carbon dioxide as a waste product; the plant life takes up this gas, separates the carbon and oxygen, utilizes the carbon for plant growth and discards the oxygen which the fish need. Then the fish eat plant forms to get carbon in organic forms. Plant life and animal life, therefore, supplement each other. The general processes of utilizing the carbon and oxygen are known as plant and animal physiology. The means employed to effect this utilization are chemical. Na- ture still remains the master chemist and man has devoted much time, effort, and study to discover the secrets of Nature’s chemical processes and to attempt to duplicate them. The study of the chemical processes of living matter is termed organic chemistry. In contrast, inorganic chemistry is concerned with mineral matter which does not contain carbon and does not originate from a vital process. Actually this differentiation needs qualification because organic compounds have been synthesized in the laboratory and there are rare inorganic compounds that contain carbon. Through the many centuries of man’s existence he has manifested an atti- tude of curiosity towards the unknown which has provided him with a fertile field for exploration. He developed special senses which allowed him a fairly 644 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY safe and comfortable existence with his environmental material. These senses helped him detect and utilize beneficial material and warned him of dangerous matter. This classification of matter was sufficient for his purpose but the nature or composition of matter has become a major source of interest. At any given period some facts about matter were known to man and he re- sorted to mystic and philosophical speculation to account for the other char- acteristics of matter. The rewards to the successful have brought immortality to the names of the adventurers and their discoveries have been stepping stones in the progress of the human race. The ancient Greeks were familiar with gold, silver, iron, and copper, and developed alloys of these elements. Although they had no idea that these metals represented elemental material their ignorance did not prevent them from employing these metals and other matter in a very practical form. The Romans added mercury, tin, and lead to this list of elements. The ancient Egyptians, Chaldeans, Hindus, and Chinese, were also familiar with many processes involving the transformation of materials as is evidenced by the mechanical separation of gold, the smelting of iron, the preparation of metallic alloys, and the manufacture of glass, pottery, and enamel ware, and animal and vegetable dyes. Until Greek philosophers, about the fifth century B. O., began to speculate upon the origin of the universe and the constitution of matter, these ancient peoples had shown no desire to investigate the nature of the chemical processes by which they made new materials from other materials; they were concerned only with the practical application of these processes. Aristotle (384-322 B. C.) believed that all matter was composed of various proportions of four simple bodies or elements, earth, air, fire, and water, to which he added a fifth, the quintessence, that acted as a carrier for the four fundamental properties of matter, hotness, coldness, dryness, and moistness. He also believed in the possibility that one form of matter could be changed into another by altering the amounts of the elemental qualities. The ancient Egyptians were highly skilled in the application of many chem- ical processes and their practical knowledge became mingled with the specula- tive theories of the Greeks following the conquest of both peoples by the Romans. From this mingling of knowledge at about the beginning of the Christian era, is believed to have originated the idea of the transmutation of metals, such as the conversion of base metals into gold. The Arabs, about the seventh century A. D., translated many Greek works on chemistry, effectively united Greek theory and Egyptian practice, and produced a definite system of chemistry in which experiment and theory were correlated. Although the Arabs added but little to existing chemical knowledge they systematically studied the properties of substances and classed all bodies as animal, vegetable, or mineral. Several chemical words, such as alchemy, alco- hol, alembic, alkali, and borax, are Arabic in origin. It appears that the Arabs also studied the chemistry of organic substances. One of the foremost chem- ists of the Arabian period appears to have been Geber (721-813 A. D.), who was familiar with the processes of crystallization, calcination, distillation, filtration, and reduction. He was also familiar with sulfuric acid, ammonium chloride, arsenous acid (arsenic trioxide), and mercurous chloride (calomel), and was acquainted with acetic and citric acids. Following the decline of Arab learning about 1200 A. D. the study of alchemy, as chemistry was then termed, spread to Europe where, during the Middle Ages, it was strongly influenced by religion, mysticism, and the doctrines of Aristotle and transmutation. During the next four centuries the chief interest CHEMISTRY 645 of the alchemists centered in the attempt to discover the philosopher’s stone or the stone of wisdom by which they could make gold out of base metals. They also sought the elixir vitae, supposed to be the sovereign remedy which would cure all disease and prolong life. Although no gold was produced and the sovereign remedy was not found, much valuable knowledge of chemical processes was gained, many new and important substances were discovered, and apparatus and methods were perfected as incidental by-products. Today thousands of tons of some of the substances discovered by the alchemists are made and used every year. The efforts which produced these results cannot be classed as scientific for they represented random explorations conducted without compass or guide. The influence of Paracelsus (1493-1541 A. D.) caused chemistry to become closely allied with medicine, and during the sixteenth and seventeenth cen- turies it was known as iatro-chemistry, iatros being a Greek word meaning physician. During this period chemistry appears to have been applied principally to the production and purification of drugs for medicinal use and to the investi- gation of their composition and action. Many chemical facts were accumulated by the iatro-chemists and standards of chemical purity and chemical individu- ality were developed. Living during this period were many men whose names will ever be asso- ciated with chemistry. A few of them were Libavius (1540-1616), Van Helmont (1577-1644), Francis de la Boe (1614-1672) (better known as Sylvius), Agricola (1494-1555), Palissy (1510-1589), and Glauber (1604-1668). Robert Boyle (1627-1691) was probably the first to study chemistry as a science, and as a science chemistry dates back only to him. His studies were with a view “to find out Nature, to see into what principles things might be resolved, and of what they were compounded.” Until the advent of Boyle there was no sound system of scientific theory based on experiment. He it was who brought into use analytical methods of determining the composition of substances, and by his work, in which he strictly observed scientific method, he cleared chemistry of the false doctrines of the alchemists and iatro-chemists. The use of Indicators in detecting acids and alkalis is due to him; he differ- entiated between mixtures, elements, and compounds; and stated that elements are substances that cannot be split up into other substances. Boyle is best known perhaps for his development of the physical laws governing the conduct of gases. As a result of Boyle’s scientific work chemistry as a science gained a firm foundation and began to progress along rational lines. Following him came Lavoisier (1743-1794) who is credited with the modern oxygen theory of com- bustion and with whom begins modern chemistry; Cavendish (1731-1810), who demonstrated the composition of air, water, and nitric acid; Scheele (1742- 1786) who discovered oxygen and chlorine, and, with Priestly (1733-1804), many new gases; and Black (1728-1799) who originated the theory of latent heat and demonstrated the precise difference between carbon dioxide and air. Lavoisier’s scientific work largely established the foundations of modern science and he completely overthrew the phlogiston theory of combustion. According to this theory a suppositional substance called phlogiston escaped into the air during combustion, and this implied that the substance remaining after burning weighed less than before burning. Boyle had recognized that the opposite was true, and in 1784 Lavoisier proved conclusively that combus- tion is a rapid chemical combination of a substance with oxygen, and that but one of the two principal gases composing air was consumed in combustion. To 646 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY the gas consumed in combustion he gave the name oxygen; the other he called azote which was later to become nitrogen. By these discoveries chemistry was definitely established as a science sep- arate from physics, although both deal with the nature of matter, are closely related, supplement each other, and overlap considerably in their fields of investigation. In general, physics is concerned primarily in comparing various material forms with the object of discovering characteristics common to both, and Boyle’s discovery concerning gases actually was in the realm of physics. Chemistry deals with the characteristics peculiar to any given form of mat- ter. It therefore endeavors to break down material into its basic elements, identify them, and determine what peculiarity differentiates a particular form of material from all other forms. The discovery of the atom, the identification of the atoms characteristic of the different elements, and their reactions be- came the task of the chemist. The idea that all matter is composed of some fundamental unit dates back to at least the fifth century, B. C., when Demo- critus not only proposed this theory but even christened this unit the “atom’' which means indivisible. John Dalton (1766-1844), an English chemist and physicist, developed an atomic theory very different from that of the ancients. He propounded that all matter consisted of atoms; that atoms are indestructible, indivisible, and differ in their nature and properties; that atoms of the same element have the same weight and properties; and that atoms of elements combine with atoms of other elements to form compounds. His table of atomic weights was first published in 1807 and his theory of the atom in 1808. This theory of Dalton’s produced a great influence on the advancement of chemical knowledge, and, with the work of Lavoisier, may be said to form the basis of modern chemistry. The theory, no longer used entirely as propounded, still serves some practical purposes. About 1900 the atom was accepted as the basic unit of structure for matter. Seventy-five elemental atoms had then been identified and on the basis of the Periodic Table, 92 were regarded as theoretically possible. The atom of each element was regarded as a complete, indivisible unit peculiar to that element, and it was found that, as Dalton had postulated, these atoms differed from other atoms in weight and valence (combining power, or affinity ; see p. 664). Combina- tions of atoms are known as molecules and an almost infinite variety of mole- cules is possible. It was discovered that the atoms of any element always combined with a definite number of atoms of another element. Helium lacks affinity for any other atom and it therefore remains uncombined chemically and has a valence of zero. The hydrogen atom which is the lightest atom by weight and was formerly used as the standard for comparison in determining the weight of other atoms, is the standard for the determination of valence. Hydrogen, with a valence of one, will unite atom for atom with atoms of like valence; for example, one atom of hydrogen unites with one atom of chlorine to form a molecule of hydrochloric acid. Any atom of oxygen, which has a valence of two, will combine with two atoms of hydrogen to form a molecule of water; any atom of nitrogen with a valence of three, will combine with three atoms of hydrogen to form a molecule of ammonia gas. As atoms are the substance of which matter is composed, they must have weight and occupy space. Dalton investigated these properties of the atom and summed up the results of his investigations in two laws which bear his name and will be discussed later. Atoms do not occur in Nature as such but in the form of molecules, and to designate them letters taken from the names of the elements are used. These CHEMISTRY 647 letters are termed symbols (see p. 661) and when used alone refer to the atom of the element, but by placing figures before or after the letters the number of the atoms or of the molecules of an element present in a substance may be shown. Thus, “O” indicates one atom of oxygen, “20” two atoms of oxygen, “02” a molecule of oxygen, and “202” two molecules of oxygen. For all practical purposes elements are considered to be substances which cannot be resolved (split up) into or built up from anything simpler. This means that an element is a substance from which no other substance can be extracted and which cannot be made from other substances. Water can be separated into hydrogen and oxygen, air can be separated into oxygen, nitro- gen, and other gases, and salt can be separated into sodium and chlorine; therefore they are not elements. But the substances into which water, air, and salt can be resolved are elements because it has never been possible to obtain any other substance from them or to make them from other substances. It has happened in the past that following improvement in analytical methods, substances considered to be elements have been found to be compounds, and the same may happen again. In studying the elements it is customary to classify them as metals and non- metals and to group them according to the similarity of chemical properties they exhibit. These groups are known as the halogen family, the nitrogen family, the alkali family, the inert gases, etc. Properties in which the elements may show similarity are natural physical form (solid, liquid, or gaseous), tend- ency to form acid or basic compounds, valence, tendency to combine with other atoms or remain inert, etc. Following the grouping of elements in families suggestions to classify the elements on the basis of their atomic weights had been made by various investigators who had traced numerical sequences among the atomic weights of some of the elements and noted connections between them and the prop- erties of the different substances. In 1863 Newlands (1838-1898), an English chemist, published his conception of the periodicity of the elements which showed that if the elements be arranged in the order of their atomic weights those having consecutive numbers frequently either belonged to the same group or occupied similar positions in different groups. He also pointed out that each eighth element starting from a given one was a kind of repetition of the first. His idea was ignored or treated with ridicule as fantastic and not worthy of serious consideration. Newland’s idea led to further investigations by a Russian chemist, Mendeldef (1834-1907), who is perhaps best known for his work on the Periodic Law. By 1850 about 60 elements had been identified and their atomic weights determined. Mendeleef noted the similar characteristics of these elements and when he placed them in series according to their atomic weights he found that these characteristics tended to repeat themselves in an orderly fashion in these series. He recognized that these properties of the elements were a periodic function of their atomic weights and on this basis he evolved his periodic classification of the elements which he published in 1869 and which, in revised form, is still in use. He did not consider this merely as a system of classifying the elements according to certain observed facts but as a law of Nature which could be relied upon to predict new facts and to disclose errors in what were believed to be true facts. This classification of Mendeleef indicated the probable existence of about 92 elements and permitted predicting the characteristics of missing and hypothetical elements with sur- prising accuracy. The existence of many of these then unknown elements has also been confirmed. 648 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY SKAlfeS 1 Group 0 Group I — r2o Group II RO Group HI —•— R2O3 Group IV RH4 ROj Group V RHj R2O6 Group VI RH2 RO3 Group VII RH R2O7 Group Vffl H 1 1.0078 o He 2 Li 3 Be 4 B 6 C 6 N 7 O 8 F 9 4.002 6.940 9.02 10.82 12.01 14.008 16.0000 19.00 Q Ne 10 Na 11 Mg 12 A1 13 Si 14 P 15 S 16 Cl 17 6 20.183 22.997 24.32 26.97 28.06 31.02 32.06 35.457 A 18 K 19 Ca 20 Sc 21 Ti 22 V 23 Cr 24 Mn 25 Fe 26 Co 27 Ni 28 4 39.944 39.096 40.08 45.10 47.90 50.95 52.01 54.93 55.84 58.94 58.69 Cu 29 Zn 30 Ga 31 Ge 32 As 33 Se 34 Br 35 63.57 65.38 69.72 72.60 74.91 78.96 79.916 Kr 36 Rb 37 Sr 38 Y 39 Zr 40 Cb 41 Mo 42 Ma 43 Ru 44 Rh 45 Pd 46 R 83.7 85.48 87.63 88.92 91.22 92.91 96.00 99 101.7 102.91 106.7 Ag 47 Cd 48 In 49 Sn 50 Sb 51 Te 62 I 53 107.880 112.41 114.76 118.70 121.76 127.61 126.92 Xe 54 Cs 55 Ba 56 Rare Earths * Hf 72 Ta 73 W 74 Re 75 Os 76 Ir 77 Pt 78 131.3 132.91 137.36 Nos. 57-71 178.6 180.88 184.0 186.31 191.5 193.1 195. 23 R Au 79 Hg 80 T1 81 Pb 82 Bi 83 Po 84 Ab 86 197.2 200.61 204.39 207.21 209.00 210 219 Rn 86 Vi 87 Ra 88 Ac 89 Th 90 Pa 91 U 92 i 222 225 226.05 227 232.12 231 238.07 * Rare Earths: La 57 Ce 68 Pr 59 Nd 60 11 61 Sm 62 Eu 63 Gd 64 Tb 66 Dy 66 Ho 67 Er 68 Tm 69 Yb 70 Lu 71 138.92 140.13 140.92 144.27 146 150.43 152.0 156.9 159.2 162.46 163.5 167.64 169.4 173.04 175.0 Figure 149.—Periodic Arrangement of the Elements. (U. S. Naval Medical School.) [Note.—Atomic numbers are shown in black-faced type at right of symbols and 1937 International Atomic Weights are shown beneath symbols] CHEMISTRY 649 In this periodic classification, usually called the Periodic Table (fig. 149), the elements were formerly arranged in groups and families according to their atomic weights. It later became apparent that in that arrangement certain irregularities existed and recent studies have shown that if the elements are arranged according to their increasing atomic numbers most of these irregularities disappear and certain properties appear at regular intervals systematically throughout the table. As a result of this it has been con- cluded that most of the properties of an element are dependent upon its atomic number. (See p. 663.) Most of the metals appear on the left side of the table and their activity increases as their names go down in any column. The nonmetals are located on the right side of the table and their activity increases as their names go toward the top of any column. The most general utilization of this table is in showing the valence relation of the various families. By referring to figure 149 it will be seen that the symbols of the names of the elements appear in numbered vertical columns and horizontal rows, each column being called a group and each row a series. The elements in each series are arranged in sequence according to their atomic numbers. The elements in series 2 beginning with element No. 2, helium, all differ markedly from each other, and element No. 10, neon, which is very similar to helium, is therefore placed in series 3, beneath helium, and followed by new elements until element No. 18, argon, is reached, which, because it is an element similar to both helium and neon, begins series 4. The elements in each vertical column have a more or less pronounced resemblance to each other which is called group resemblance and is especially noticeable in the valence of the elements in any group. Because of the re- semblance in valence the elements in a group form oxides, hydroxides, acids, and salts of the same general formula, and the hydrides and oxides of maximum valence are shown in formulas at the top of certain columns, the R in the formula representing any element in the column. It will be noted that in most of the columns the elements are placed on either the right or the left side of the column which is because those elements on the right side of the column resemble each other much more closely in both chemical characteristics and physical properties than they do those on the left side. Thus the elements in a group are separated into such groups, or families, as they are called, which usually are named after the first element of the family appearing in a column, as the nitrogen family, the sulfur family, etc. Elements in series 2 and 3 which do not fall distinctly into either family of their group but combine properties of both, are known as type elements because they represent the general characteristics of their group. In series 4, 5, and 6 appear 18 elements which are divided into 2 rows, one row consisting of 11 elements appearing on the left side of the columns and the other of 7 elements appearing on the right side of the columns. Of the 11 elements in the upper rows of these series 3 are placed in Group VIII because they resemble each other very closely, being metals with almost identical characteristics, and, if arranged as the first three elements in new rows, they would interrupt the regularity of periodic recurrence of properties of the elements already appearing in series 2 and 3. The series containing 18 elements are often spoken of as long series and those containing 8 as short series. It is an interesting fact that in the Periodic Table there is no place for the element hydrogen which, while one of the most important of all the elements, seems to have no close relation to any other element and to stand quite alone. Because of its great chemical activity it cannot be placed with the inert gases 650 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY in Group O and although it has some characteristics similar to those of the metallic elements in Group I, it is a gas and not a metal and therefore cannot be placed with the elements in Group I. There are some other irregularities in the Periodic Table which will not be discussed here. Of even more importance is the fact that Mendeldef’s classification presented a fundamental picture of atomic structure. No longer could the elemental atom be accepted as the ultimate form of matter. The table indicated that the atom consisted of variable but definite combinations of some simpler unit of matter, a situation that was distressing to the chemist who had accepted the various elemental atoms as the ultimate form of matter. This confused state did not begin to clarify until radiology appeared on the scene at the turn of the century. The X-rays were discovered by Roentgen in 1895 and the physicist studied them and discovered that the emanations from the negative or cathode pole of the X-ray arc consisted of a stream of very minute particles much smaller than atoms. In the United States Dr. R. A. Millikan determined the velocity and weight of these particles and discovered that they carried a negative charge of electricity. These were known as cathode rays and it was also known that another form of matter was thrown off from the positive pole. Discovery that different elements produced the same emanations of these particles proved that their basic composition was similar. Next it was demonstrated that the quantity of positive emanations was proportional to the atomic weight of the element under investigation. These discoveries changed the entire chemical picture. The atom is now postulated as a structure similar to the solar system of which the Earth is a part. At its center is a core or nucleus consisting of particles charged with positive electricity called protons and other particles bearing charges of negative electricity called electrons, both occurring in pairs. The characteristics of an atom are due to the number and arrangement of these pairs of protons and electrons, which, in a normal atom, are equal in number, and the total charge of positive electricity therefore neutralizes the total charge of negative electricity. All protons and usually about 50 per cent of the electrons are located in the nucleus. The other electrons are relatively at a great distance from the nucleus and rotate around it in definite orbits, as the planets rotate in orbits around the sun, and are called “planetary” or rotating electrons. Consequently the space occupied by an atom is relatively as free from substance as is the solar system. This explains the phenomenon of the penetrating power of the X-rays in the body and even in iron. That is, they penetrate because they fail to collide with either protons or electrons in their transit through space. The proton has about 1,850 times the mass of the electron and determines the mass or weight of the atom. So large is the mass of a proton as compared with the mass of an electron that the mass of the atom of any element is approximately proportional to the number of protons in the atom. The simplest atom, that of the element hydrogen, consists of only one proton with one “planetary” electron. In contrast the atom of the element uranium has 238 protons in its nucleus and its specific gravity is approximately that of gold. It is possible to estimate the number of protons in any atom by comparing the known value of its atomic mass with that of hydrogen with its one proton. The total “planetary” or rotating electrons located in the orbits of an atom determine its atomic number, or position, in the Periodic Table, while those located in the outermost orbit usually determine its valence. The outermost CHEMISTRY 651 orbit is termed the valence orbit, and the electrons in this orbit are called valence electrons. The chemical properties of an atom are very largely due to the “planetary” electrons. As the atomic weight of an atom increases the number of “planetary” electrons also increases. The hypothetical position of the “planetary” electrons is in a series of orbits around the nucleus, the greatest number of orbits being seven. The helium atom has only 2 “planetary” electrons which rotate in a single orbit. Helium and hydrogen are the only 2 elements whose atom has but 1 orbit. Additional electrons assume positions in orbits outside of the original or innermost orbit. The number of rotating electrons in an orbit varies according to the atom of the element, and the maximum number of electrons which may be in any 1 orbit also varies. This arrangement of nucleus and orbits is known as the octet theory and has the virtue, at least, of proposing an atomic structure that harmonizes with the Periodic Table. In the first or innermost orbit there may be no more than 2 rotating electrons, in the second no more than 8, in the third no more than 18, in the fourth no more than 32, in the fifth and sixth, with two exceptions (mercury and lead), no more than 18, and in the seventh or outermost no more than 8. The atom of an element may, therefore, be regarded as being composed of a definite number of pairs of protons and electrons arranged in a definite fashion and reacting in a characteristic manner. The atom has functioned so effectively as a unit of matter that only comparatively recently has its complex structure been demonstrated or even suspected. The atoms of some elements, as lithium, boron, and lead, differ in their atomic mass although their chemical properties are the same. The difference in mass is due to there being different numbers of protons in the atoms. Atoms having the same chemical properties but different atomic masses are termed isotopes, and evidence now shows that many elements are mixtures of isotopes. Radium B, radium D, thorium B, and actinium B are all isotopes of lead and of one another. From facts brought out in the introduction it is possible to define chemistry as the science which treats of the composition of matter when considered as composed of either electrons, atoms, or molecules; and of the changes which modify or alter the composition of matter. When two or more substances combine to form a new substance, or substances are divided into their ele- mentary components, the resulting products exhibit entirely new characteristics and are incapable of identification with the original. As previously stated the science of chemistry is separated into two main divisions on the basis of the structure of matter. These divisions are inorganic chemistry, which is the study of the elements, their properties, applications, and chemical combinations, and organic chemistry, which is the study of carbon compounds as found in, or as by-products of, living organisms. Applied chemistry has many special branches depending upon the industry or profession in which it is employed, i. e., physiological, pharmaceutical, industrial, etc. By observing the infinite variety of forms in which matter occurs in Nature, and the constant changes taking place, the unlimited applications of chemistry are obvious. The changes which occur in matter may be physical or chemical, and the earliest knowledge of chemistry was obtained by observing the changes continuously occurring in Nature but it was not until man began to experi- ment on the substances of Nature that his chemical knowledge made progress. In the performance of his experiments man found certain conditions were 154294°—89 42 652 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY invariable, and from these constants the fundamental laws of matter have been derived. Suppose a stick of sulfur held in the hand is rapidly twirled or thrown through the air. It may be shattered or broken but it still is sulfur; any change occurring is superficial and has to do only with shape or position. Suppose the sulfur is placed in a mortar and finely ground, then fine iron filings added, and the two intimately mixed until a gray colored powder is obtained. If the powder is fine enough, it is possible that the naked eye may not detect the different particles and that the mass will present a uniform and homogeneous appearance, but the mixture is not homogeneous. Should a portion of this mixture be placed beneath the lens of a microscope the particles of sulfur and iron readily can be distinguished from each other. The mixture is therefore heterogeneous; that is, composed of unlike or dissimilar particles and is simply a physical mixture resulting, as is said in chemistry, from a physical change. The proportion of either ingredient may be changed at will, either by adding more of one of the ingredients or by the removal of one of those present. By adding carbon disulfide the sulfur can be dissolved from the mixture and poured off, leaving the iron, or by applying a magnet the iron may be withdrawn. Suppose that a part of this mixture of powdered iron and sulfur is placed within a test tube and heated over a Bunsen burner; the mass will fuse, will reach a red heat, and finally will glow brilliantly, and when cooled will present the appearance of a black, hard, fused mass. If a fragment be broken off, powdered, and placed beneath the microscope it will be seen that it presents a homogeneous appearance, all particles being similar. An attempt to remove a portion of the particles with a magnet will fail, and any solvent used will act on all particles alike. Clearly the mass is different from the original powder because the heating of the sulfur and iron together has produced a chemical change in which a new substance or compound has been formed. This new compound is called ferrous sulfide and is composed of approximately 35 per cent of sulfur and 65 per cent of iron by weight. These weights are constant and never vary, as is the case in physi- cal mixtures. From this fact the following law has been adduced: “A chemical compound is always composed of the same ingredients in the same proportions by weightThis is known as Dalton’s law of Constant Proportions. Another example of this law is shown in the heating of 1 part of alcohol with 2.09 parts of oxygen (a total of 3.09 parts) which gives 1.91 parts of carbon dioxide and 1.18 parts of water (again a total of 3.09 parts). Dalton also discovered the law of Multiple Proportions which is: If two or more elements form more than one compound, and one is considered as a constant, the different weights of the elements that combine with the constant are simple multiples of each other. In water the weights of hydrogen and oxygen are in a ratio of 1 to 8 but in hydrogen dioxide the ratio is 1 to 16. Likewise carbon monoxide is composed of 3 parts of carbon and 4 parts of oxygen while carbon dioxide consists of 3 parts of carbon and 8 parts of oxygen. The law of Reciprocal Proportions states that: The proportions in which any two elements unite with a third are the same when they unite tenth each other, or simple multiples thereof. For example: Carbon dioxide contains 12 parts of carbon combined with 32 parts of oxygen; in methane 12 parts of carbon are combined with 4 parts of hydrogen; if hydrogen and oxygen form a compound, in accordance with this law, they should combine in proportions of 4 to 32 or in simple multiples thereof as 1 to 8, as is found in water. CHEMISTRY 653 A law, as the word is used in science, is a statement summing up facts which actually have been found to be true after a large number of experiments have been performed carefully, accurately observed, and verified. It has been shown by the foregoing that a chemical change differs from a physical one in that, while physical changes are superficial, the changes occurring during a chemical reaction are internal. The whole nature of the reacting substances undergoes a profound change, resulting in the formation of new substances markedly differing in characteristics and properties from those of the original substance or substances. To discover what elements are in any substance and to learn what are the laws governing the actions of elements upon each other is the principal object of chemistry. The process by which the composition of substances is deter- mined is known as analysis, and that by which substances are produced by combining elements, is known as synthesis. SOME PHYSICAL PHENOMENA OF MATTER In the introduction it was stated that the sciences of chemistry and physics are both concerned with the investigation of the properties of matter and are closely related. It is therefore evident that the study of chemistry must be supplemented by and include a knowledge of the physical properties of matter from the viewpoint of the science of physics. Accordingly there will next be given a brief discussion of some of the physical phenomena of matter which are essential to the study of chemistry. Physics is the science which treats of the phenomena associated with matter in general and of the laws governing those phenomena. It is also known as Natural Philosophy and formerly included the sciences of chemistry, biology, astronomy, and geology which are now classed as individual sciences. Characteristics and properties of matter. Anything that has weight and occupies space (takes tip room) is known as matter. In the science of physics the unit of matter is the molecule; in chemistry the unit is the atom. Matter exists in three states: Solid, when it has a definite volume and shape and does not require confinement; liquid, when it has a definite volume, requires confinement on sides and bottom, and takes the shape of the containing vessel; and gaseous, when it has neither definite volume nor shape and must be confined on all sides. Science has demonstrated that all matter is composed of about 92 elemental substances which cannot themselves be resolved or split up into two or more substances and cannot be produced from other substances. It follows, then, that matter which can be resolved into two or more elemental substances is compound matter; therefore matter composed of molecules made up of two or more ele- mental substances is termed a compound. One of the first fundamental laws of both chemistry and physics that man discovered in his experiments with substances in Nature was the indestructi- bility of matter, which means that, regardless of what chemical or physical change may take place, matter can neither be destroyed nor called into exist- ence. After a chemical or physical change has occurred there remains as much matter as there was previous to the change and if a substance is changed physically or chemically it still exists in another form, as has been shown in the examples of mixing sulfur and iron and of heating sulfur and iron. An- other example is the burning of a piece of wood weighing 10 Gms. in a closed 654 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVA vessel containing a definite weight of oxygen. After combustion has taken place it will be found that the weight of the resulting materials, including gases formed, will be 10 Gins, plus the amount of oxygen used from the vessel. This law concerning the indestructibility of matter is also known as the law of Conservation of Matter. All matter has the property of volume which is designated by the terms length, breadth, and thickness. Matter possesses mass and weight. The mass of a substance, which does not vary, is the measure of the quantity of matter the substance contains. Weight is the measure of the difference between the attraction of the earth and that of surrounding bodies for bodies on the surface of the earth. The weight of a body may vary according to the quantity of matter it contains and its distance from the earth’s center. Porosity is a property of matter that signifies that a certain amount of space exists between the molecules of a substance. This property is quite evi- dent in the common sponge and exists in varying degrees in all matter. Compressibility allows the volume of a body to be diminished by pressure. It is a proof of porosity and exists to a great degree in gases. Elasticity is the property which allows a body to resist deformation and resume its original form or volume when the altering force ceases to act. Solidity is the property wherein the relative position of the molecules of a substance is fixed and cannot be altered without the application of force. Fluidity is the property wherein the relative position of the molecules of a substance is not fixed and they are capable of gliding over each other with comparative ease, the body assuming the form of the vessel in which it is placed. Tenacity is the property of a substance by which it resists the total separa- tion of its molecules. Ductility is the property of a substance whereby its form may be changed by the action of traction or pressure. Malleability is the property of a substance which permits it to be hammered or rolled into sheets. Hardness is the resistance which substances offer to being scratched by other substances. This is only a relative property for an object which is hard in reference to one substance may be soft in reference to others. Brittleness is the relative property of a substance which allows it to be broken when struck a sharp blow. Transparency is that property of a substance which allows the passage of rays of light. In studying chemistry the word “force” is often used in connection with the natural phenomena affecting the many chemical and physical changes taking place and described. For this reason the definition of the word and its attend- ant word, energy, is given here. Force is the action of one body upon another, or is that which produces, changes, or stops motion. It is a manifestation of energy which may be caused in different ways, as by electricity, heat, and light. Energy is a property possessed by all matter which may be defined as the capacity to do work and exists in one of two states, kinetic or potential. Kinetic energy is that state recognizable as heat, light, or motion. Potential energy is the latent power of all matter to produce a change, and is defined as the energy of position. A supported object has potential energy due to its position. When the support is withdrawn its potential energy is transformed into kinetic energy by the motion of the falling object. Kinetic energy is rep- CHEMISTRY 655 resentative of motion, visible in the movement of a mass, or evident in light and heat due to the invisible motion of molecules. Just as matter can neither be created nor destroyed, neither can energy be created nor destroyed, and the total amount of energy in the universe remains constant and unchangeable. Energy that apparently is lost actually goes off in some other form of energy, most of it in heat. From a given amount of heat a relative amount of mechanical motion can be obtained, and vice versa. A similar relation exists between heat and electrical energy, and between these and chemical energy. By burning a definite amount of material a rela- tive amount of heat is obtained; and by the application of this heat a corre- sponding amount of chemical action is produced. Although there is no direct way of proving that energy is never destroyed, all experimental evidence points to the principle that: Enei'gy is never created and never destroyed and all forms of energy are convertible, one into another, without loss, the total amount of energy in the universe remaining constant. This principle is termed the law of the Conservation of Energy and is applied to atomic and molecular changes, to electrical phenomena, to biological phenomena, in fact, to all the processes of Nature. Pressure. Pressure is that force which tends to decrease the volume or alter the shape of a substance in direct proportion to the density or weight of the substance exerting the pressure. The density of a substance is measured by its specific weight which is represented by an abstract number showing the density of a given volume of substance as compared with that of water, hydrogen, or some other standard substance, both substances having the same temperature or the temperature of each being known. This is more commonly known as specific gravity. For example: 1 cc of sulfuric acid weighs 1.84 Gms; the weight of 1 cc of distilled water is 1 Gm; therefore, sulfuric acid is 1.84 times heavier than water. The equation used in determining specific weight (or gravity) is: w Sp. wt= "r- W being the weight of a given substance and Y being the weight of an equal volume of the substance used as the standard. That gases are easily compressed is evident from the inflation of an automo- bile tire or a balloon. Even the atmosphere of the earth is under pressure, the air pressure at sea-level being 14.7 pounds per square inch (one atmosphere). This is due to the layers of the atmosphere exerting their weight upon the earth’s surface, the pressure gradually decreasing with altitude. By doubling the pressure on a given quantity of gas in a tube its volume is decreased to y2; by trebling this pressure its volume is decreased to %, etc. This principle is the basis of Boyle’s law of the Compressibility of Gases; The volume of any dry gas, the temperature remaining constant, varies inversely to the pressure applied. The equation used in determining the volume of a gas is: YP=Y'P'; V being the original volume, P the original pressure, V' the new volume and P' the new pressure. Problem.—What will be the volume of 10 liters of gas, calculated at 14.7 pounds pressure, if it is subjected to a pressure of 29.4 pounds, the temperature remaining constant? 10 X 14.7= V' X 29.4; 29.4V'= 147; V'= 5 liters (new volume) 656 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Heat. All matter is composed of very small particles called molecules, which are in constant motion. As the velocity of these molecules increases, the tempera- ture of a body rises. A decrease in molecular velocity causes a corresponding decrease in temperature. Consequently heat may be defined as kinetic energy due to molecular motion. Heat is derived from many sources, the sun being the most important. Evidence that the interior of the earth is highly heated is furnished by molten rock issuing from volcanoes, and boiling water spouting from geysers. Chemical reactions are important sources of heat, especially those of oxidation. Mechanical action can be transformed into heat, friction being a common example. The heat of an object and its temperature are different entities. It is possible for a body to have a high temperature and little heat; it may have a low temperature and little heat; it may have a high temperature and much heat; or it is possible for it to have a low temperature and a large quantity of heat. A burning match has a high temperature but gives off little heat, whereas a steam radiator has a comparatively low temperature but gives off much heat. Temperature is measured by degrees, heat by calories. The terms “hot”, “cold” and “warm” are used to indicate temperature, but their use is only relative. Inasmuch as man’s temperature sense is unreliable thermometers necessarily are used to measure temperature. Several scales are used on thermometers, the Centigrade and Fahrenheit being the most common; the former is employed in scientific measurements, the latter in weather observations and household applications. For the conversion of degrees of Centigrade tem- perature to Fahrenheit degrees and vice versa, see chapter on Pharmacy. All substances expand to some degree when heated and contract when cooled. This phenomenon is most apparent in gases. Unlike liquids and solids, all gases have approximately the same coefficient of expansion. That all gases conduct themselves in practically the same manner under the influence of changes in temperature and pressure is explained by the assumption or hypothesis that equal volumes of gases at the same temperature and pressure contain the same number of molecules. This is known as Avogadro’s Hypothe- sis. The coefficient of cubical expansion for gases is 1/273 of the volume at 0° C., or 0.00367 for each degree Centigrade. If a given volume of gas at 0° C. is cooled to a minus 100° C., it will be found that its volume has decreased 100/273, or, it has only 173/273 of its former volume. Theoretically, a gas cooled to a minus 273° C. would lose 273/273, or all of its volume. Actually it would be liquefied, then solidified. At zero volume, molecular motion having ceased, the body would be without heat, or absolutely cold. Consequently minus 273° C. is considered absolute zero, and from this factor the absolute temperature scale is calculated. The uniform expansion of gases is defined by Charles’ law; If the pressure be constant, the volume of a given mass of dry gas is directly proportional to the absolute temperature. This law may be expressed by the equation: V:V'::T:T'; V being the original volume, V' the new volume, T the original temperature, and T' the new temperature. The Centigrade temperature first must be con- verted into absolute temperature by adding 273 to the given Centigrade temperature. Problem.—What will be the volume of 117 cc of gas, calculated at 52.26° C., if the temperature is decreased to 5° O., the pressure remaining constant? CHEMISTRY 657 117: V':: (52.26+273) : (5 +273) ; 117: V':: 325.26: 278; 325.26V'=32526; Y'=100; new volume is 100 cc. To determine the volume of a gas subjected to changes in temperature and pressure the following formula is used: T T' Problem.—What will be the volume of 500 cc of gas, calculated at 2° 0. and a pressure of 10 pounds, if it is subjected to a pressure of 100 pounds at 35° O.? 500X10 _Y'X 100 2 +273 35+273 5000 100V' . 27500Y'=1540000 275 308 V'=56; new volume is 56 cc. Molecular physics. It has been explained that all matter is made up of exceedingly small par- ticles called molecules. In gases the distance between these molecules is relatively great, whereas in liquids the particles are closer together; but in all cases there is sufficient space between adjacent molecules to permit them to move freely. In solids this space is greatly diminished, proportional to the density of the substance. The conception that molecules of all matter are in constant motion is known as the kinetic theory. (See chapter on Pharmacy). The velocity of this motion depends upon the nature of the substance, its state, and its tempera- ture. Under a powerful microscope small particles suspended in a liquid can be seen moving backward and forward erratically or jumping up and down in ceaseless motion. These movements are caused by the motion of the liquid’s molecules, which, by their impact on the particles drive them hither and thither. This motion, known as the Brownian movement, is a manifestation of molecular motion and was first noticed in 1827 by a Scottish botanist named Brown while examining suspensions of pollen grains in water under a microscope. Evidence of this molecular motion is demonstrated by the diffusion and evaporation of matter. If a jar containing carbon dioxide is placed directly under one containing hydrogen, with their openings together, it will be found that the carbon dioxide will diffuse upward and mix with the hydrogen. As carbon dioxide is 22 times heavier than hydrogen, had it been placed above, its movement downward into the jar of hydrogen could be explained by its greater weight. The movement upward of the carbon dioxide, diffusing through the hydrogen, is therefore possible only because of the movement of the mole- cules. The diffusion of liquids through a semipermeable membrane, which is continuously occurring in living cells, is known as osmosis and is explained by this molecular motion. In the evaporation of water the molecules are con- stantly bounding upward; some mix with air currents and are carried away while others rebound off the air molecules back into the water. If the resist- ance of the air molecules is removed by vacuum, evaporation proceeds more rapidly. Some evaporation occurs from solids and is readily noted with substances like camphor, musk, and iodine crystals. 658 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAYY Because there is ceaseless molecular motion it is remarkable that all sub- stances do not evaporate rapidly and expand indefinitely. Yet many solids have great tensile strength and enormous forces are required to pull them apart. Opposing molecular motion there is a strong force binding together the mole- cules. This force of attraction between like molecules is called cohesion. Unlike molecules may also adhere to one another strongly. The force of attrac- tion between unlike molecules is called adhesion. An examination of the surface of water in a container shows that it is not exactly level or plane, but slightly concave. The edge of the column in contact with the glass is raised above the general level, forming a crescent-shaped sur- face called the meniscus. The lifting of the water at the edge is caused by the adhesion of the water molecules to the glass, this attraction being greater than the cohesion between the water molecules. A line drawn through the bottom of the meniscus of transparent and the top of opaque liquids usually is selected as the reading point. When a column of mercury is examined the edges are found to he depressed and the surface slightly convex, because in this condition cohesion between the molecules is greater than their adhesion to the glass. If a finger is placed in thick molasses and withdrawn one is conscious that a certain amount of force is required to separate the molecules of the molasses. This demonstrates the cohesion of molecules. Surface tension.—The surface of all liquids has a tendency to contract, which tendency is known as surface tension and is the result of action of the mole- cules of the liquid. In contracting the surface of the liquid tends to assume a spherical shape because a sphere is the geometrical figure in which a given volume has the least surface; in other words, surface tension tends to reduce the surface area of a liquid, or to make the surface area smaller. A molecule in the interior of a liquid is attracted equally from all directions by the cohesion of the surrounding molecules, while those on the surface have only molecules of air above to attract them. As a result the attraction on the surface molecules is unbalanced and they are attracted only by the force tend- ing to pull them out of the surface toward the interior of the liquid. This unbalanced attraction causes the surface to contract to as small an area as possible and it then acts like an elastic membrane. Such a condition may be demonstrated by floating a clean needle on the surface of water. A careful examination shows that the‘needle floats in a hollow, the water behaving as though a thin elastic film or membrane had been stretched across its surface; the weight of the needle is not great enough to break through. A wet needle cannot be floated in this manner due to the cohesion of the water molecules; hence, the experiment is more easily performed if the needle is covered with oil. Like water, all liquids have this property. On alcohol the film lacks the strength of that on water. Many oils possess a weaker film but have greater viscosity; that is, the resistance offered by a liquid to the relative motion of its particles causes more friction within the liquid itself and gives it a sup- portive surface. Capillarity.—This property of liquids is due to the combined forces of adhesion and surface tension. The adhesion of water to the surrounding me- dium causes the surface of the water to become concave. Surface tension tends to decrease the surface area, or flatten it, by contraction. The two forces working together raise the liquid above the surrounding level. The height to which a liquid will be lifted depends upon its density and the strength of the liquid film. CHEMISTRY 659 The phenomenon of capillarity is governed by the following rules: 1. Liquids rise in capillary tubes if the liquids wet the tubes and are depressed if they do not; 2. The elevation or depression is inversely proportional to the diameter of the tube; and 3. The amount of elevation or depression decreases as the temperature increases. Solution.—It is common knowledge that a piece of salt dissolves when it is placed in water. Water in this case is called the solvent and salt the solute, and the molecules of the solute occupy space between the molecules of the solvent. All solutions possess the following characteristic properties: 1. A solution is of the same nature throughout and each unit volume of the solvent contains the same amount of the solute; 2. The solute does not separate from the solvent upon standing unless the temperature changes or some of the solvent is lost by evaporation; 3. Only a definite weight of solute can be dissolved in a given volume of solvent at any given temperature, and when the solvent holds all it can of the solute at that temperature it is said to be saturated; 4. The solubility of a solid generally increases with a rise of temperature; and 5. The solubility of a solid varies with the nature of the substance and the solvent used, water being the greatest general solvent and alcohol perhaps second. Crystallization.—When the saturated solution of a solid is cooled or evap- orated, some of the solute separates from the solvent in the form of crystals. Crystallization may occur when a liquid changes from the liquid to the solid state. During crystallization the molecules of the solid arrange themselves in definite geometric figures. The types of the crystals depend upon the nature of the substance and the conditions under which crystallization occurs. Solubility of Liquids.—It is possible to dissolve one liquid in another, and in such a case either liquid may be considered the solvent. Two liquids which are mutually soluble are said to be miscible; if they are insoluble they are said to be immiscible. If an oily liquid is shaken with water so that finely divided particles of oil remain suspended in the water the resulting product is called an emulsion. Solubility of gases.—All gases are soluble to some extent in water. When water is heated, bubbles, consisting of air which was dissolved, rise through the liquid and are liberated; hence, an increase in temperature decreases a liquid’s ability to dissolve gases. This ability is increased by pressure and is employed in the manufacture of carbonated beverages. The increase in a liquid’s ability to dissolve gases under pressure is governed by Henry’s law; The volume of a gas that can be absorbed by a liquid is directly proportional to the pressure applied. The elements. INORGANIC CHEMISTRY The earth, the atmosphere, plants, animals, and everything with which man is surrounded are composed of certain elementary substances in more or less complex forms. These substances are termed elements and each has definite characteristics and properties, chemical and physical, which are governed by a set of constants or laws. Regardless of the way in which the elements com- bine or separate, they do so according to the same definite principles or laws, a number of which have been discussed. The elements at present known to science are shown in the table on page 660 and the atomic weights given are the 1937 International Atomic Weights. As explained in the introduction elements are substances which cannot be resolved into or built up from anything simpler. This definition takes into consideration only the ordinary types of chemical change and takes no cogni- zance of those changes in elements that occur when they are subjected to bom- 660 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY bardment by a-rays emitted by radioactive substances, an example of which is the breaking down of nitrogen into hydrogen and helium by such bombardment. Notation.—The names of many elements are derived from Greek or Latin words that signify some distinguishing feature or peculiarity of the element; others are named after mythological personages or deities, minerals containing them, places where they were discovered; and some are named after planets in the solar system. The names of the more recently discovered elements usually end in “um” or “on”. Table of the Elements Element Symbol Atomic Weights (0=16) Atomic Number Valence Specific Gravity Water Air Actinium Ac 227.0 89 Alabamium. .. ... 219. 0± 85 1 Aluminum . ... ... A1 26. 97 13 3 2. 7 Antimony (Stibium) . .. .. . ... Sb 121. 76 51 3,5 6. 7 Argon . .. _ A 39. 944 18 o 1.38 Arsenic _ - .. . 74.91 33 3, 5 5 7 Barium ... Ba 137. 36 56 2 3 5 Beryllium .. _. _ Be 9. 02 4 2 1 84 Bismuth .. ... Bi 209. 00 83 3, 5 9 8 Boron ... __ .. . B 10. 82 5 3 2 0 Bromine .... Br 79.916 35 1 3 12 Cadmium __ _ Cd 112. 41 48 2 8 6 Calcium. Ca 40. 08 20 2 1 65 Carbon. _ ....... _ C 12. 01 6 2 4 2. 26 Cerium Ce 140.13 58 3 4 6. 92 Caesium. _ _ ... _ ... Cs 132. 91 55 ' 1 Chlorine ..... . _ . .... Cl 35. 457 17 1 2 49 Chromium. ... .. . Cr 52. 01 24 2, 3 6 7 1 Cobalt . . ... Co 58.94 27 2, 3 8 9 Columbium Cb 92. 91 41 3, 5 12 7 Copper (Cuprum) Cu 63.57 29 1, 2 8.9 Dysprosium Dy 162.46 66 3 Erbium.. . . . .... Er 167. 64 68 3 4. 77 Europium .. ... ... Eu 152.0 63 3 Fluorine. .. F 19.0 9 1 1.31 Gadolinium Gd 159. 6 64 3 1 31 Gallium.. Ga 69. 72 31 3 5 94 Germanium. ... Qe 72. 60 32 2, 4 5 47 Au 197.2 79 1, 3 19.32 Hafnium . . ... Hf 178.6 72 4 Helium _ „. _ He 4.002 2 o 0.137 Holmium ... ._ ... Ho 163.5 67 3 Hydrogen ... . .... II 1.0078 1 1 0.069 Illinium ... 11 146.0 61 3 Indium. _ ... In 114. 76 49 3 7.12 Iodine . ... __ I 126.92 53 1 4 94 Iridium .... . Ir 193.1 77 3,4 22 42 Iron (Ferrum) ..... Fe 55.84 26 2, 3 7.86 Krypton ._ __ __ . Kr 83.7 36 0 2.18 Lanthanum . La 138.92 57 6 155 Lead (Plumbum) Pb 207. 21 82 2,4 11 34 Lithium . ... Li 6.94 3 i 0.534 Lutecium .... . Lu 175.0 71 3 Masurium ......... Ma 98.8 43 Magnesium Mg 24. 32 12 2 1. 74 Manganese. . Mn 54.93 25 2,4,6,7 7 42 Mercury (Hydrargyrum) . Hg 200.61 80 L 2 13 59 Molybdenum... ... _ . . Mo 96.0 42 9.01 Neodymium Nd 144. 27 60 3 6 95 Neon ... . . ..... Ne 20.183 10 o 0. 674 Nickel.._ .. Ni 58.69 28 2,3 8 75 Nitrogen. ... ........ N 14.008 7 3, 5 0.967 Osmium . ._ Os 191. 50 76 2,3,4, 8 22. 48 Oxygen _ ... ... ...... 0 16.00 8 2 1.105 Palladium ... . ... ...... Pd 106. 70 46 2,4 12 16 Phosphorus _ P 31.02 16 3,6 1 83 Platinum Pt 195.23 78 2,4 21 37 Pollonium. Po 210,0 84 3,5 Potassium (Kalium) _ ... . K 39.096 19 1 0 870 Praseodymium Pr 140. 92 59 3 6.48 Protoactinium ... Pa 231.0 91 3,5 Radium Ra 226.05 88 ' 2 Radon Rn 222.0 86 0 Rhenium ... Re 186. 31 75 2, 4, 6, 7 Rhodium _ Rh 102.91 45 3 12. 44 Rubidium. Rb 85.48 37 1 1.52 CHEMISTRY 661 Element Symbol Atomic Weights (0 = 16) Atomic Number Valence Specific Gravity Water Air Ruthenium _ 101.7 44 3,4,6, 8 12. 06 Samarium .. 150.43 62 3 7.76 Scandium ___ Sc 45.10 21 3 Selenium __ _ Se 78.96 34 2, 4, 6 4. 65 Silicon . . ... Si 28. 06 14 4 2.42 Silver (Argentum) _ _ _ _ _ Ag 107. 88 47 1 10.50 Sodium (Natrium) . . Na 22.997 11 1 0.971 Strontium.. ... Sr 87.63 38 2 2.54 Sulfur S 32.06 16 2,4,6 2.046 Tantalum . ... . ._ Ta 180. 88 73 5 16.6 Tellurium Te 127. 61 52 4,6 6.25 Terbium ... Tb 159. 20 65 3 Thallium ... _ . T1 204. 39 81 1,3 11.85 Thorium . Th 232.12 90 ' 4 11.2 Thullium.. __ Tm 169. 40 69 3 Tin (Stannum) 118. 70 50 2, 4 6.85 Titanium. _ _ _ Ti 47. 90 22 2,4 4. 5 Tungsten _ _ . W 184.00 74 6 18.7 Uranium ... .. ...... ... U 238. 07 92 4,6 18. 68 Vanadium.. . V 50. 95 23 3,5 5.69 Virginium ...... Vi 225. 0± 87 Xenon . Xe 131. 30 54 0 4. 42 Ytterbium.. Yb 173.04 70 3 Yttrium ... ... ... ... Y 88.92 39 3 3.80 Zinc ... Zn 65. 38 30 2 7.00 Zr 91.22 40 4 4.15 Table of the Elements—Continued For convenience and simplicity in expressing the composition of substances made up of various elements, in representing the results of chemical action, and in working out chemical equations, there is used an abbreviated form of chemical language or a system of symbols. These symbols are abbreviations of the names of the elements and have become fixed by long usage. They usually consist of the first letter of the names of the most important, most abundant or earliest-discovered elements, as O for oxygen, H for hydrogen, N for nitrogen, etc., and in cases where several elements have the same initial letter some other letter of the name is added, Ni for nickel, Ba for barium, Bi for bismuth, etc. In a few instances the symbol is derived from the old Latin name of an element, as Au for gold, Cu for copper, Fe for iron, Na for sodium, etc. As has been stated before, symbols refer to the atom of an element, and the number of atoms or molecules of an element in a substance is shown by placing numbers before or after the symbol. A symbol therefore represents not only the name of an element but a definite quantity of that element, an atom or a molecule, and as atoms and molecules have weight it also represents a definite weight of the element. A collection of symbols, with any attached numbers, shows how the atoms or molecules of an element are united in a substance, and such a collection is known as a chemical formula. A chemical formula is a collection of symbols and numbers showing the kinds and amounts of elements contained in a substance, or compound. A formula standing alone represents one molecule of the substance. A symbol of an element contained in a molecule represents one atom of that element. If more than one atom is present in a molecule the proper small numeral is placed after and slightly below the symbol, and if more than one molecule is present a large numeral is placed before the symbol. Placing a large num- eral before a symbol or before a collection of symbols multiplies everything following the numeral including the subscripted small numerals. For example: H20 is the formula for water, and as so written represents one molecule of that compound, while 2ILO represents two molecules consisting of four atoms of 662 HANDBOOK OP THE HOSPITAL CORPS, U. S. NAVY hydrogen and two atoms of oxygen. To be correct the valences (see p. 664) in a chemical formula must balance. It has been stated that oxygen has a valence of II and that the valence of hydrogen is I. Manifestly one atom of hydrogen is not the equivalent of one atom of oxygen in combining power, and if the two are combined it will require two atoms of hydrogen to balance or equalize one atom of oxygen, because in any given compound all valences of each atom must be employed; that is to say, no element may have a free valence in any saturated compound. (See p. 665.) The valence of barium is II, and therefore one atom of barium can unite with one atom of oxygen to form a molecule of barium oxide. If the valence of one element of a compound is a multiple of the valence of the other element in the compound, take the symbol of the element with the lower valence as many times as it is contained in the valence of the other element and write the quotient as the exponent of the element with the lower valence as directed before. To write the formula of silicon oxide and have it balance, silicon having a valence of IV and oxygen II, the symbol of oxygen must be multiplied by 2. The formula of silicon oxide, there- fore is SiO-2. If the valences of the two elements concerned are not eqiiiva- lent and are not multiples of each other, write the symbols side by side and take each symbol as many times as the other has valences. The valence of aluminum is III, and one atom of that element is not balanced by one atom of oxygen with a valence of II, so to write the correct formula of aluminum oxide it is necessary to take the symbol of aluminum twice and the symbol of oxygen thrice, which gives the formula A12G3. This is the simpliest arrangement in which the two can be combined to form a compound. Chemical formulas are of four kinds, which are named and described as follows: Empirical formulas show the quality but not the quantity (other than relative) of compounds, as in (CJHioOb)*, the formula of starch, but when some special arrangement of the atoms of the substance is made to show not only the quality and quantity of the elements in the compound but the relationship between the different elements or groups of elements they are known as rational formulas, an example of such an arrangement being (0H)2S02 the formula of sulfuric acid. Graphic or structural formulas are those in which the relative position of the atoms is shown as a picture, the exact linking of the atoms being given with the symbols of the elements entering into the compound. Graphic formulas are shown on pages 714 and 715. Stereochemic formulas are used in the study of such advanced chemistry that they will not be discussed here. In order to understand the use of chemical formulas, especially graphic for- mulas, a knowledge of the combining power of elements, which is based on that of the atoms of the element, is necessary. Atomic weight.—The symbols of the elements represent a quantitative por- tion of the substance they designate, and each symbol signifies the smallest division of that element present in a molecule, and denotes a definite and fixed quantity, as, for example, in the formula NaCl the symbol Na repre- sents 22.997 parts of sodium and the symbol Cl represents 35.457 parts of chlorine as combined in a molecule of sodium chloride. Atoms of the same element always possess the same weight in relation to any definite standard selected with which to compare them, but the weight of an atom of one element is never the same as that of an atom of any other element. Atomic weight is purely relative and, as it is impossible to weigh single atoms, it is determined by comparison with the weight of some element selected as a standard. For many years hydrogen, the lightest of all known elements, was used as the standard for atomic weights and its atomic weight arbitrarily was placed as 1, but hydrogen is very difficult to obtain CHEMISTRY 663 in a pure state and mistakes as to its actual weight frequently occurred. Each time an apparatus or process was developed which came a little nearer to obtaining pure hydrogen, and consequently nearer the determination of its true weight, a revision, entailing recalculations of the atomic weights of all other elements, became necessary. This caused much work and finally the use of hydrogen as a standard was discontinued and oxygen substituted. Under the old system the atomic weight of oxygen was 15.88 but in the new system was fixed at 16. Thus when it is stated that the atomic weight of sulfur is approximately 32, it is meant that the weight of an atom of sulfur bears the same relationship to the weight of an atom of oxygen as 32 bears to 16, and similarly, as the atomic weight of iron is approximately 56, the relationship between the atomic weights of iron and of oxygen is as 56 is to 16. The absolute weight of the atom of any element is unknown but definite relative weights have been determined, and upon them all quantitative chemical analysis depends. Molecular weight.—The weight of a molecule is the sum of the weights of all atoms which compose it. A molecule of hydrochloric acid is composed of an atom of hydrogen and an atom of chlorine. The atomic weight of hydrogen being 1.008 and the atomic weight of chlorine 35.457, the molecular weight of hydrochloric acid is the sum of 1.008 and 35.457, or 36.465, and the rela- tionship of the molecular weight of hydrochloric acid is to the atomic weight of oxygen as 36.465 is to 16. The molecular weight of any substance expressed in grams is called the gram-molecular weight, or mole; thus, 18.016 Gm. is a mole of water and 32 Gm. a mole of oxygen. At a given temperature and pressure the gram- molecular, or molar, weight of a gas will, in accordance with Avogadro’s hypo- thesis, occupy a constant volume which is called the gram-molecular volume or the molar volume. When the given temperature is 0° O. and the given pressure is 760 mm. the molar volume of a gas is 22.415 liters. Atomic number.—This is a number that indicates the position of an element in the Periodic Table and represents the net positive electrical charge on the nucleus of an atom. It also represents and is equal to the number of planetary electrons outside the nucleus upon which depend the chief physical and chemical properties of the elements; therefore a knowledge of the atomic numbers of the elements is important. The net, or excess, positive electrical charge on the nucleus of an atom is equal to the number of natural units of positive electrical charge (protons) in the nucleus of an atom minus the number of natural units of negative elec- trical charge (electrons) in the nucleus. As the helium atom has an atomic mass of 4 and as the atomic mass of an atom is approximately proportional to the number of protons in the atom, the nucleus of the helium atom is consid- ered as containing 4 protons. There being twice as many protons as electrons in the nucleus of an atom it follows that there are but 2 electrons in the nucleus of the helium atom and therefore the net or excess positive electrical charge is 4 minus 2 or 2, which is the atomic number of the element helium, and also represents and is equal to the number of planetary electrons outside the nucleus. For the helium atom to be electrically neutral it must have an equal number of positive and negative electrical charges, and as but 2 of the 4 electrons necessary to neutralize or balance the 4 protons are in the nucleus, the other 2 electrons must be outside of the nucleus. In most cases atomic numbers follow the order of the atomic mass of the elements. Each element has its own atomic number which determines its 664 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY place in the Periodic Table and all its properties except those depending on atomic weight. Atomic numbers are determined by X-ray spectra according to the method devised by H. G. J. Moseley (1887-1915), a brilliant British physicist killed in the World War. He found that the X-rays emitted by different elements when bombarded by cathode rays in a vacuum tube give different X-ray spectra and hence the X-rays were of different wavelengths. By studying these charac- teristics he was able to calculate the number of the element giving off the X-rays, and his discovery made it possible to determine the number of elements, how many were missing, and to correct discrepancies in the position of certain elements in the Periodic Table as based on their atomic weights. Valence. This is the term used to describe the power of the atoms of elements to com- bine with the atoms of other elements. It sometimes is spoken of as the saturating or replacing power of elements and as chemical affinity. As stated in the introduction hydrogen is taken as the standard in fixing the valuation of valences, and its valence arbitrarily is designated as one. In some elements valence is comparative only, because they will not combine with hydrogen, as mercury, for instance. The valence of such elements is determined by compari- son of the noncombining element with one which will combine with hydrogen. Therefore, as one atom of mercury will combine with one of oxygen, and it is known that one oxygen will combine with two hydrogen, the valence of mercury is said to be two. If an element has such combining power, or valence, that it can unite with two atoms of hydrogen, it is said to have a valence of two; if it can unite with four atoms of hydrogen its valence is four, etc. Elements which do not form compounds, such as the inert gases, are said to have no valence. Elements often are designated as univalent, divalent, trivalent, or tetravalent respectively when their atoms are possessed of one, two, three, or four valences. Similarly, they may be designated as monads, diads, triads, tetrads, etc. The valence of an element may be indicated also by Roman numerals placed slightly above and to the right of the symbol. The table following, which is illustrative only, shows the difference in the number of hydrogen atoms which combine with one atom of several elements in the hydrogen compounds given, and indicates the valence of the element in the compound with which the hydrogen has combined. Valence of I Valence of II Valence of III Valence of IV HC1 H20 HsN H4C HBr H2S HsP H4Si HF EtaSe HaAs HI HsTe H3Sb Chlorine and bromine which combine with hydrogen, atom for atom, are monads. Oxygen and sulfur require two atoms of hydrogen for saturation and are therefore diads. Sodium does not combine with hydrogen, but as in its reaction with hydrogen chloride (HC1) it replaces hydrogen, atom for atom, its valence as a monad is established. Similarly, as an atom of zino in its reaction with hydrogen chloride displaces two atoms of hydrogen, it is a diad. The valence of all the elements toward hydrogen is constant and unchangeable. A hexad atom can unite with and completely neutralize six atoms of a monad, three atoms of a diad, two atoms of a triad, or one atom of a hexad. An atom of a tetrad could unite with four atoms of a monad, two atoms of a diad, or CHEMISTRY 665 one atom of another tetrad. Furthermore, any triad, tetrad, etc., atom may neutralize several different kinds of atoms of lower valence at one and the same time. For example, a hexad may unite with one triad, one diad, and one monad, or with any other combination of atoms the sum of whose valences does not exceed six. Valence may be likened to men having as many hands as elements have valences and each hand ready to grasp the hand of another person and form a bond. Sometimes, as has been shown, one hand may be so strong that it takes more than one of the other’s hands to hold the grip which forms the bond. Certain elements may possess more than one valence and this condition is known as polyvalence. An atom of mercury, for example, under some circum- stances will combine with one atom of chlorine, forming mercurous chloride, commonly known as calomel, and under other conditions it will combine with two atoms of that element to form mercuric chloride, popularly called bichloride of mercury. Just why an element may possess this quality of polyvalence is not known; it only is known that they do possess it. When an element changes its valence, either higher or lower, the change usually is in degrees of two, changing from monad to triad, diad to tetrad, etc., or the reverse. Exceptions to this rule are known, however, as iron, which changes its valence 1 degree at a time, from a valence of 2 to a valence of 3, and mercury, which changes from 1 to 2. That these varying valences may be indicated, the terminations ous and ic are used, denoting the lower and higher valence, respectively, as cuprous oxide, Cu20, in which copper has the valence of 1, and cupric oxide, CuO, in which copper has the valence of 2. When chlorine, bromine, and iodine combine with hydrogen they are always monads, as they also are when combined with metals, as copper chloride (CuCh) or bismuth chloride (Bids). But when the various elements combine with the diad oxygen, or such elements as chlorine and bromine, variations in the valence of these elements develop. This valence toward oxygen or the halogens, is termed halogen valence, usually increases in increments of 2, and is an example of polyvalence. The variation of the oxygen, or halogen, valence of sulfur and osmium is shown in the table following. Valence of III Valence of IV Valence of VI Valence of VII SjOj SOa S03 S2O7 Valence of II Valence of IV Valence of VIII OsO OsOj OSO4 When all the valences, or bonds, of one element have been satisfied or replaced by a like number of another element, the resulting compound is said to be saturated, but where one of the elements of a group has a valence less than its maximum valence the group is said to be unsaturated. In some com- pounds it is believed that the valences for which there is no satisfying valence may hook up with each other, although this is not known positively. Groups of elements having unsatisfied valences are known as radicals (SO*, N03 OH, etc.). During chemical change a radical behaves as a unit similar to an indi- vidual atom and has a definite valence and retains its structure throughout the reaction. 666 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In ammonium chloride, NHUCl, it is known that nitrogen acts as a pentad and has all valences satisfied, while in ammonia gas, NHS, it is known that nitrogen acts as a triad having 3 valences satisfied. The fact that when hydrochloric acid is added to ammonia gas, ammonium chloride is produced, with the con- sequent increase in valence from 3 to 5, and the knowledge of similar occur- rences in other compounds, has led to the belief that possibly the unsatisfied valences unite with each other in compounds which otherwise would not be saturated. Valence also is indicated by using the symbol of the element with bonds, or arms as they might be called, equal to the degrees of valence, extending from it. It is not necessary that these bonds be attached to the symbol in any definite position, but only that the proper number of bonds corresponding to the degree of valence be used. To illustrate this the following examples are given showing the placing of the required number of bonds about the symbol of the element and the name of the degree of valence: Monad Diad Triad Tetrad Pentad H— —O— —B— —C— =P= Different positions of bonds II I / // X? _P= =p= -p< =?<; -p< Practical use of graphic formulas to show the composition of compounds is obtained by linking the bonds of the symbol of one element with those of others, so that all bonds are joined, always remembering that one bond of an element can be linked with only one bond of another element. Some examples of common compounds written graphically are: Water Nitric Acid Ammonia (gas) //° /H H—O—H H—O—N/ Nr-H N) \H To show how the formula of a compound may be written, acetic acid can be represented in any of the following ways: H O CII3COOH; C2H402; H—C—ft—0—H A In writing the usual chemical equations none of the various ways of indicat- ing valence is ordinarily used, and it must be remembered that under no circum- stances do the bonds used in graphic or structural formulas actually exist; they are used only to indicate theoretically the relationship or linking together of the different atoms in compounds. As stated in the introduction and in the discussion of atomic structure the valence of atoms is determined by the number of electrons contained in the outer shell or orbit. This is due to the gain or loss of electrons in this shell or orbit in order to complete its symmetry. Metallic elements lose electrons read- ily while nonmetallic elements readily gain them. Amphoteric or intermediate elements, which partake of the characteristics of both metals and nonmetals, have the ability to gain or lose electrons according to the influences by which they are surrounded. 667 CHEMISTRY Beryllium with an atomic weight of 9, has in its nucleus 9 protons and 5 electrons (fig. 150(a)). Surrounding the nucleus is one complete orbit or shell of two electrons and there are two valence electrons in the outer orbit. It becomes symmetrical by the loss of its two valence electrons, leaving it with an excess of two positive charges, forming a bivalent ion, Be++. Therefore, it requires one atom of a diad or two atoms of a monad for saturation. Hence, beryllium readily combines with one atom of oxygen, which requires two elec- trons to complete its outer shell; or it might combine with two atoms of hydro- gen, each hydrogen atom requiring one electron to complete its respective outer shell. Boron can lose three electrons, hence, it is trivalent (fig. 150(&)). The carbon atom contains 4 valence electrons and will become symmetrical either by the addition or loss of 4 electrons (fig. 150 (c)). While the ion of carbon is unknown, the compounds formed by the carbon atom indicate its intermediate nature and demonstrate that its chemical behavior is governed by the same principles that control both the metals and nonmetals. In the oxygen atom there are 6 electrons in the outer shell (fig. 150 id)). If it were to resort to the symmetry of the helium 'atom it would be compelled to lose 6 electrons from its outer shell, but by gaining 2 electrons it assumes the symmetry of the neon atom (fig. 150 (e)). After gaining 2 electrons it has an excess of 2 negative charges, so it is said to have a valence of minus II. The outer shell of the fluorine atom assumes symmetry upon the addition of 1 electron, therefore its valence is minus I (fig. 150 if)). The electronic theory. Electricity is spoken of as being static when it remains stationary, or at rest, and as dynamic, when it is in action, or in motion, and produces power, heat, and light. Static electricity may become active by friction. It has long been known that when certain solids, as amber, rubber, glass, etc., which do not conduct electricity, are rubbed with a piece of wool, or silk, or fur, they acquire the ability to attract light objects such as small pieces of paper, cork, pith, feathers, etc. The solids are then said to have become electrified, or charged with electricity and practically every solid, when rubbed with a different substance, will acquire this property. They may also become electrified by liquids, as when liquids pass through pipes. The electrification in all cases is the result of friction activating the static form of electricity in the substances themselves. If a rubber rod is electrified by rubbing with wool and then suspended by a thread and another electrified rubber rod is brought near to it, the two rods will repel each other, but if a glass rod that has been electrified by rubbing with silk is brought near to the suspended rubber rod, the two rods will attract each other. This is evidence that there is more than one state of electrification and is the basis for the law that like electrifications repel and unlike attract. To the electrification found on the glass rod the name positive has been given, and to that on the rubber rod the name negative. When a body has become electrified it is said to be charged with electricity, or to have a charge of electricity, and the flowing of this charge from one body to another is termed a current of electricity. For a current of electricity to flow from one body to another it is necessary for the bodies to be connected by substances which will conduct, or carry, the current, and such substances are known as conductors, a familiar example being copper wire. Substances which will not conduct electricity are known as nonconductors or insulators and are used to support conducting substances and prevent them from losing their electrical charge, common examples being rubber and glass. Due to 154294°—39 43 668 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY If) FLUORINE (i) NITROGEN fit) HYDROGEN ATOM (•) HELIUM //) LITHIUM (*) HYDROSEN MOLECULE (=) BERYLLIUM (*) BORON M CARBON (*) OXYGEN NEON (1) SODIUM (m) LITHIUM FLUORIDE M ARGON Figure 150.—Shells and orbits of elements. CHEMISTRY 669 the fact that in different substances the degree of conductivity varies it is not possible to classify them strictly as either conductors or nonconductors, and they are therefore spoken of as being good or poor conductors, metals being the best and glass, rubber, sealing wax, and like substances the poorest. Many important facts concerning the relations between elements have been determined through knowledge gained by the practical application of the law that like electricities repel and unlike attract, and that bodies charged with positive or negative electricity act in the same manner. It has been explained that all matter is considered as composed of electrons charged with negative electricity and of protons charged with positive elec- tricity. This has been shown by experiments carried out on solutions of sub- stances made up of known elements in water, contained in vessels called decomposing cells. In these cells are placed the positive and negative termi- nals, or electrodes, of an apparatus producing electricity, to which metallic plates are usually attached. If perfectly pure water, which is an extremely rare product, is then poured into the cell it will be found that no electricity will pass through it. If, however, a small amount of an acid, a base, or a salt be added to the water the solution will readily conduct the electric cur- rent. Substances which, when added to water, make it possible for the solution to conduct electricity are known as electrolytes, and substances which do not, as organic bodies like sugar, starch, and albumin, are known as nonelectrolytes. The substances used as electrolytes are electrically neutral or balanced, or, in other words, the protons and electrons in their atoms are equal in number. An electric current in passing through a solution of an electrolyte brings about a chemical decomposition called electrolysis in which the electrolyte is separated or split up into two groups of particles, each of which flows either to the positive or negative electrodes and on contact becomes electrically neu- tral. If the water in a decomposing cell is made slightly acid it splits up into hydrogen gas and oxygen gas when the current passes through the solution, the hydrogen gas being liberated at the negative, or cathode electrode, and the oxygen gas at the positive, or anode, electrode. The liberation of hydrogen at the negative electrode shows that it was charged with positive electricity, and the liberation of oxygen at the positive electrode shows it was charged with negative electricity. Passage of an electric current through water in which copper sulfate has been dissolved causes copper to be de- posited on the negative electrode and oxygen to be finally liberated at the positive electrode. Electrically charged particles of matter are called ions, from a Greek word meaning “to go”, and ions charged with positive electricity are known as cations, because they go to the cathode, or negative, electrode, while those charged with negative electricity are known as anions, because they go to the anode, or positive, electrode. Cations and anions carry the matter with which they are associated, and on touching the electrodes the electric charges leave them and pass into the electrodes while the matter is deposited or liberated. In the electrolysis of hydrochloric acid in water (fig. 151) the acid ionizes into positive hydrogen cations and negative chlorine anions, with molecules of hydrogen gas and of chlorine gas being liberated later. These examples have also shown that during electrolysis there is movement of the electrified particles of matter or ions in the solution toward the positive and negative electrodes in accordance with the law that unlike electricities at- tract. It is believed this movement is the result of the loss or gain by a neu- tral atom of an electrolyte of one or more electrons in the formation of the 670 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY particles of matter called ions. If electrons are lost the particle or ion becomes positively electrified, and if they are gained, the particle is negatively charged. In the theory of electrolytic dissociation, or ionization, any one molecule of an electrolyte breaks down into one or more cations and one or more anions, the total number of the positive and negative charges being equal. Each cation and anion forms a nucleus to which may be attached a variable number of mole- cules of the solvent, and as a result, the moving particle or ion is complex. Fig. 151.—Electrolysis of hydrochloric acid. The valence of the ion corresponds with the valence of the element or group of elements from which it is derived and is equal to the number of electric charges borne by it. The process of electrolytic dissociation or ionization, or the formation of ions, may be represented as follows: Hydrochloric acid Hydrogen ion Chlorine ion — -~>H+ + Cl- ztH+ + ci- Sulfuric acid 2 Hydrogen ions Sulfate ion 2 Hydrogen ions Sulfate ion H2S(y + SO r “ In the ionization of sulfuric acid positively charged hydrogen ions and nega- tively charged sulfate ions are formed by the dissociation of sulfuric acid molecules. CHEMISTRY 671 The arrows as used in the examples show that the reactions are reversible; that is, the products under suitable conditions will produce the original substances. By electrolysis the positive hydrogen ions are attracted to the negative elec- trode where they lose their charges of positive electricity and are liberated as molecules of hydrogen gas. When the sulfate ions reach the positive electrode the process, while similar, is more complicated, but the liberation of oxygen is the final, or end, result. Through the observation of these and similar phenomena the electronic theory has been developed, by which many chemical reactions have been made clear. Numerous experiments have shown that the atoms of elements are composed of positive and negative electrically charged particles which are present in sufficient numbers to exactly balance or neutralize each other. The unit of positive electricity, the proton, is designated by placing a single plus sign above and to the right of the symbol of the element, while that of negative electricity, the electron, is designated by placing a single minus sign in the same position. As a result of experiments concerning the electrical properties of the atom certain postulates or assumptions have been laid down: 1. All atoms are composed of positive and negative electrical charges in equal quantities. 2. Each atom is composed of two main parts. The central part is called the nucleus; surrounding it at some distance are particles of negative electricity called electrons, considered to be arranged and rotating in concentric circles or orbits about the nucleus. 3. The nucleus consists of both positive and negative electricity, with positive charges always present in larger numbers than the negative. 4. The atomic number of an element signifies the number of extra protons present in its nucleus. 5. The external rotating or planetary electrons always exist in a sufficient number to balance the excess protons in the nucleus of the element (fig. 150 (ff) )• The external electrons are associated in groups of shells, or orbits, the first shell or orbit being nearest the nucleus and complete, or symmetrical, when it is occupied by two electrons. The external electron of hydrogen is located in this shell (fig. 150 (h)), as are the two external electrons of helium (fig. 150 (i)). The lithium atom has 3 external electrons, so the third is contained in a second shell (fig. 150 (j)) outside of the first. The second shell is complete when it contains 8 electrons. Sodium which has 11 external electrons is demonstrated with its eleventh electron in a third shell (fig. 150 (0) outside of the first two. The third shell, like the second, may be completed with 8 electrons; in heavier elements it contains 18. The fourth shell may contain 32 electrons. The evi- dence of the nature of these shells and the number of electrons they contain was obtained largely through a study of valence. When an atom has in its outermost shell less than the number of electrons required for completeness, or symmetry, it always shows a tendency to combine with other atoms. For example: Lithium with an atomic number of three has only one electron in its outermost shell; fluorine with an atomic number of nine has seven. These two elements readily combine, the single electron of the lithium shell supplying the necessary electron to complete the outer shell of the fluorine atom, and producing the compound, lithium fluoride, which power- fully resists any effort to separate the two atoms (fig. 150 (j, f, & m)). When 672 HANDBOOK OF THE HOSPITAL CORPS, XT. S. NAVY an element is extremely active its atoms combine with each other forming molecules (fig. 150 (fc)). Atomic structure.—The hydrogen atom is the simplest of any of the elements and like all other atoms is electrically neutral, containing an equal number of electrons and protons. It readily loses one electron forming an ion which contains an excess of one proton and is represented by H+. This electron, situated outside the nucleus and intimately connected with the chemical be- havior of the atom, is termed the valence electron. All atoms possess valence electrons with the exception of the inert gases, helium, neon, argon, etc. (fig. 150 (i, e, S n)) and the basis of chemical activity is the interchange of the valence electrons among the elements to produce various compounds. The activity of these electrons is demonstrated when a substance is dissolved in water and the various atoms receive and contribute their outer electrons, according to their nature, to form ions. An atom that contributes, or loses, its electrons is left with an excess of protons, and hence is a positive ion or cation. A negative ion is formed when an atom receives, or gains, electrons, and as an excess of electrons is then present in its structure it is a negative ion or anion. In this form the individual atoms are electrically unbalanced. Upon removal of the solvent the ions revert to their original molecular structure. In the study of the structure of atoms, the atomic numbers assigned to the various atoms are indicative of the number of excess protons contained in the nucleus, which excess in every case corresponds to the number of planetary electrons in the various shells surrounding the nucleus. To clarify the study of atomic structure it is necessary to consider the relative weights of the atoms (atomic weights) as whole numbers, and in most cases the atomic weights are so nearly whole numbers that the fraction of error is negligible. Also, it will be found that the approximate atomic weights represent the total number of protons or the total positive electrically charged units contained in the nucleus of the element considered. Therefore: Atomic numbers designate both the number of protons, or positive factors, in excess and the number of electrons contained in the electronic shells of a given atom; and the approximate atomic weights correspond to the total number of protons in a given atomic nucleus. The atomic number of helium is 2 which denotes an excess of 2 protons which are balanced by 2 planetary electrons. The nucleus with its surrounding elec- trons forms a stable configuration in that the external shell is complete, there being no valence electrons present to combine it with other atoms. This is true, in fact, for helium, being an inert gas, is incapable of combining with other elements. This condition is indicative of a valence of zero. Lithium, with an atomic weight of approximately 7 and an atomic number of 3 must contain 7 protons and 4 electrons in its nucleus and 3 rotating or plane- tary electrons in its electronic shells. Two of the planetary electrons are firmly held in the first shell, as are the two outer electrons in the helium atom. The remaining electron in the second shell produces an asymmetrical arrangement, in that the second shell requires 8 electrons for completion. This disturbs the forces within the atom. Theoretically, to overcome this asymmetry the valence electron is removed, forming a lithium ion (Li+). This is true because the lithium atom is very active chemically, having a valence of one. It is convenient to represent atoms containing more than one shell or orbit as cubes, as shown in figure 150, or as a series of concentric circles around the nucleus, but it must be remembered that such figures merely represent the postulated relationship of the various parts of the atom, do not imply that atoms are necessarily cubical or spherical in form, and that the electrons are not stationary but revolve about the nucleus. CHEMISTRY 673 Reactions and equations. In chemistry these terms are synonymous in so far as their use is concerned. It has been shown how chemical symbols are used to indicate the composition of a substance, and chemical symbols are used further to show exactly the nature of the chemical changes which occur when different substances come in contact with each other. The grouping of the symbols in this manner is called a reaction, but, strictly speaking, the statement is an “equation of the re- action,” as it is written in the form of an equation and both sides of the equa- tion must balance. It is customary to speak of these expressions either as reactions or equations. The signs of addition, +, and equality, = or —are used in expressing the reaction, but as the reaction may be reversible the use of the words “results in,” “produces”, or “gives” is preferred to “equals”, and use of the arrow to the sign of equality. When an arrow is pointed upward (t) it indicates that a gas is liberated and when pointed downward (I) that a substance has been precipitated or thrown out of solution. The use of chemical symbols to express a chemical equation may be described as a shorthand method of recording what has happened in a chemical reaction and obviously must be a statement of facts that actually occurred. In other words, the equation is written to fit the reaction, and consequently equations cannot be written until it is known through testing and experimenting ex- actly what has happened in any given instance. The general laws of chemistry and physics and observations of large numbers of reactions have been studied until it is known just what will happen in the majority of cases where specific reagents (compounds used for producing reactions) are brought in contact. In writing reactions or equations, three difficulties usually are encountered. These difficulties are to know if a given change will occur, to know the amount of the substance to be used, and to know the character of the substance formed in the reaction. The first difficulty is experienced because the varying electri- cal natures of the elements affect their affinities, and because of the disturbing of ordinary affinities by the formation of insoluble bodies wrhen liquid substances capable of producing them are brought together, the facility with which bodies that can be volatilized or converted into a gas diminish in their chemical power when this occurs, and in the proportion or concentration of the substances brought in contact with each other. The second difficulty is caxised by the necessity of knowing the ratio in which the substances can react upon each other, which is determined by their valences. The third difficulty encountered is due to the electrical relations of the ions of the substances coming in contact with each other, in which it is necessary to remember that electro-positive ions can unite only with electro-negative ions. Reactions are chemical changes in substances and changes in matter of this character affect the molecules of the substances involved therein. Molecules are the smallest portions of a chemical compound that retain the properties of that compound and are composed of two or more atoms which are, in turn, the smallest possible divisions of the elementary substances. The atoms composing the original molecules dissociate, or combine with like and unlike atoms of other molecules, to form new substances possessing entirely different properties from the original. For example; If an electric current is allowed to act upon water the water loses its identity as such and is resolved into two gases, hydrogen and oxygen. These products no longer possess the characteristics of water. In the rusting of iron, due to its combination with the oxygen of moist air, a reddish-brown powder is formed, iron oxide, which no longer has the characteristics of either iron or oxygen. 674 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY The attraction of one atom for another permits the formation of a com- pound. This attractive force is known as chemical affinity and varies greatly, not only among the various elements, but also with each element itself by the action of varying physical forces. The first condition necessary to produce a chemical change is intimate contact and freedom of motion between molecules, so that they may exchange their atoms. With solids this condition is obtained by dissolving them in a liquid medium. Some chemical reactions take place upon molecular contact while others need the application of physical forces such as heat, light, or electricity, along with molecular contact, to produce the desired change. The most common types of reactions or chemical changes are: 1. Synthetic reactions, or direct combination, in which simple compounds or elements unite to form complex substances, as: SOa+ELO—^EhSCh; 2. Analytical reactions, or decomposition, which embrace a large variety of reactions whereby the elements are separated from their compounds for the purpose of forming insoluble bodies or stable substances capable of being iden- tified and weighed, as: BaCl2-f Na2S04—>BaS04-l-2NaCl, in which reaction the barium sulfate is precipitated and therefore, the amount of it or of the sodium chloride may be determined ; 3. Substitution, or displacement, wherein one element of a compound is dis- placed by another element, as: Fe+2HC1—^FeCh+EB; 4. Double decomposition, or metathesis, is the most common type and is the mutual reaction of substances in solution to form new compounds by the inter- change of atoms or atomic groups (radicals), as: H2S044-2NaCl—>NaS04 + 2HCl; and 5. Dissociation, or reversible reactions which are those produced by physical forces such as heat, light and solution. The molecules of certain compounds separate into simpler forms which exist as long as the favoring conditions con- tinue. When these conditions cease to act, the products of dissociation recom- bine to form the original substance: HCl+water±^H++Cl- NH4C1+heat NH3+HC1 It has been previously stated that under suitable conditions the products of reactions will produce the original substances and that such reactions are known as reversible reactions. This means that, to a certain extent, a reaction and its degree of completion may be controlled partially and in some cases made to proceed in either direction. Such reactions are also known as incomplete. The reaction between calcium oxide and carbon dioxide is of this nature, for, if a stream of carbon dioxide is allowed to pass over calcium oxide, calcium carbonate is produced; while if calcium carbonate is heated, that compound is decomposed into calcium oxide and carbon dioxide. Such a reaction is written as follows: This equation simply means that the reaction may proceed from left to right, or vice versa, according to the conditions obtaining at the time. Equations.—A chemical equation expresses several important laws, among which are those of the Conservation of Matter and of Definite Proportions, indicates the weights of the reacting substances and their resulting products, and must balance and conform to the laws which govern it. In writing the chemical formula for potassium chlorate and its reaction due to the applica- tion of heat, experimental facts show that oxygen is liberated and the potas- sium chlorate converted into potassium chloride. It might be thought that CaO+COa CHEMISTRY 675 the equation KClOs+heat *02+KCl would express the reaction but exam- ination shows that it is incorrect, in that while there are 3 atoms of oxygen on one side of the equation there are only 2 on the other, and the equation therefore fails to conform to the law of Conservation of Matter. To correct this the equation must be balanced by placing numbers, as necessary, before each of the chemical formulas, so that finally there will be the same number of atoms of each element on each side of the equation. These numbers show the smallest amount of the elements that can enter into the reaction, and must be whole numbers as it is obvious that half an atom cannot be used. In the foregoing equation the oxygen molecule contains 2 atoms of O, but the formula for KClOa contains 3, and the 03 and 02 do not balance. Therefore, some multiple of 3 and 2 must be represented in the equation. As the smallest multiple of 3 and 2 is 6; enough KClCh must be used to furnish 6 atoms of O, and as 6-H5=2, that number of parts of KCIO.i is required. The correct equa- tion then will read: 2KCl(>+heat—>302-f2KC1. In stating equations it is necessary to remember that the molecular formulas of elements entering into combinations to form new compounds must always be used. Especially is this true of the gaseous elements such as hydrogen, oxygen, chlorine, nitrogen, etc,, which can exist only in the free or molecular state. All but 11 of the elements have one atom to the molecule, the exceptions being ar- senic, phosphorus, sulfur, selenium, bromine, iodine, fluorine, chlorine, hydrogen, oxygen, and nitrogen. Therefore when these elements are used in equations they must appear as As*; P4; Ss, So, S2, or S; Ses; Br2; I2; F2; Cl2; H2; 02; and N2. When dealing with reactions generally between acids and metals, or metallic oxides or hydroxides, it is safe to assume that a salt of known content will be formed; for example, when zinc is placed in a solution of hydrochloric acid it is known that zinc chloride will be among the products formed and that hydro- gen will be another product. In connection with the writing of equations showing reactions, the following rules, with examples, are given to assist the student. 1. Any metal plus any acid gives a salt of the metal plus hydrogen. Example: 2Ag + 2HC1—»2AgCl + II. 2. Any hydroxide plus any acid gives a salt of the acid used plus water. Example: Metal Acid Salt Hydrogen NaOH + + H=0 Hydroxide Acid Salt Water 3. Any carbonate plus any acid gives a salt of the acid used plus carbon dioxide plus water. Example: Na2C03 + 2HNOs—> 2NaN03 + C02 + H20 Carbonate Acid Salt Carbon Water Dioxide 4. Any metal plus water which produces a reaction gives a hydroxide of the metal plus hydrogen. Example: 2Na + 2H20 -> 2NaOH + H2 Metal Water Hydroxide Hydrogen By the use of equations in conjunction with certain mathematical procedures it is possible to ascertain the percentage of each element entering into the composition of chemical compounds, the quantities of substances involved in 676 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY chemical reactions, the combining weights of elements, etc. The procedures necessary to obtain such information are spoken of as chemical arithmetic or stoichiometry. Stoichiometry is that branch of chemistry which treats of the relations between the properties of substances and their composition, and of the methods of cal- culating the quantities of substances, by weight or volume, involved in chem- ical reactions. It is based on the fundamental laws of chemistry. Chemical formulas and equations are made up of chemical symbols which represent atoms of elements and, as previously explained, definite weights of matter. The figures representing these weights are used in the mathematical calculations of stoichiometry, as shown in the examples appearing hereafter, in which also are explained the methods used in such calculations. If 1 atom of zinc and 2 molecules of hydrochloric acid will produce 1 molecule of zinc chloride and 1 of hydrogen it follows, then, that a definite weight of each of the former must produce a definite weight of each of the latter, be- cause, through the law of Conservation of Matter, no matter, or weight, can be lost or gained in any chemical reaction. The actual weight of no atom is known but the relative weights are and it is those which are used in chemical equations. After writing the symbols of the elements involved in this reaction in the form of an equation, figures representing the atomic and molecular weights of the elements and compounds are placed in the proper position just above the symbols in the equation and the result observed. Zinc has an atomic weight of approximately 65.4, and as only one atom of that element is involved in this equation that figure is placed above the symbol of zinc. The atomic weight of hydrogen is, roughly, 1, and of chlorine 35.5. The molecular weight of hydrochloric acid therefore is 36.5, but as that figure represents the weight of only one molecule and in this equation two molecules are necessary, the number is doubled and the number 73 placed above the formula of hydrochloric acid. The molecular weight of zinc chloride must be the atomic weight of zinc (65.4) plus twice the atomic weight of chlorine (35.5X2=71) or 136.4, which is written, above the formula of that compound, and 2, of course, is the molecular weight of hydrogen. The equation then appears as follows: 65.4 73 136.4 2 Zn+2HCl-> ZnCl2+H2. As no weight may be lost or gained in a chemical reaction, the combined weights of zinc and hydrochloric acid should just equal the combined weights of zinc chloride and two atoms of hydrogen, and it is found that they do, the sum of the weights of the elements and compounds on either side of the equality sign being 138.4. Now, irrespective of what the actual weight of the atoms or molecules may be, this equation shows that 65.4 parts by weight of zinc and 73 parts by weight of hydrochloric acid will produce 136.4 parts by weight of zinc chloride and 2 parts by weight of hydrogen. One may substitute any unit of weight desired—grains, ounces, tons, kilograms, or grams—for the word “part” and the actual weights involved read off as such. If a chemical equation is written correctly, the combined weights of the reacting substances will exactly equal the combined weights of all the products. It naturally follows that if a compound is formed which contains more atoms of an element, or requires two or more radicals to balance it, and those amounts are not contained in one molecule of the substance from which it is to be supplied, more molecules of that substance must be used, as previously explained. In other words, enough of the substance must be used to supply the amounts CHEMISTRY 677 needed. Suppose metallic calcium is dropped into some hydrochloric acid. It is known that calcium chloride (CaCh) will be formed, the equation being: 40 73 111 2 Ca+2HCl->CaCl2+H2 As a molecule of calcium chloride contains two atoms of chlorine and one molecule of hydrochloric acid contains only one atom of chlorine, it is necessary to use two molecules of that acid. Determining the weights involved in the equation, shows that 111 parts of calcium chloride and 2 parts of hydrogen are formed by the action of 73 parts of hydrochloric acid on 40 parts of calcium, all parts being by weight. By applying these principles the weights of any substances required to produce a definite weight of a specific compound may be calculated. First the equation must be stated and balanced, next the reacting weights must be written in their respective places above the equation, and then, by making a simple statement in proportion, the required weights easily are ascertained. Suppose the problem is to ascertain the quantity of hydrochloric acid neces- sary to produce 75 grams of calcium chloride. By reference to the preceding equation it is noted that 73 grams of hydrochloric acid will produce 111 grams of calcium chloride. It follows, then, that: wherein it is found that x equals 49.32+ grams of hydrochloric acid. Simi- larly, had the problem been to determine how much calcium chloride could be made from 1,850 grams of hydrochloric acid the statement would have been: 73: 111:: x: 75 73: 111:: 1850: x and x would equal 2,813+ grams of calcium chloride. The next examples given show a different method of working the problems occurring in chemical equations although based on the same principles as the others. Suppose it is desired to make 20 Gms. of oxygen (O) without wasting material. Set down the formula and write the amount, in grams, above the substance to be obtained. Place an “x” to represent the unknown quantity above the substance to be weighed. Below the formulas write the formula weights, which are calculated from the atomic weights. The number before the formula is used as a multiplier to obtain the equation weight. The numbers for KC1 are omitted as they do not enter into the problem. x 20 2KC10i -> 302 +2KC1 Atomic weights: K, (39) ; Cl, (35~5) ; O, (16 X 3)~ O, (l(Tx 2)' Formula weights; 122.5 32. Equation weights: 2 X 122.5 = 245. 3 X 32 = 96. if 245 grams of KClCb produce 96 grams of O, then: 245:96:: x: 20 96x = 4900 required to produce 20 grams of O. x = 51, the number of grams of KC103 The “x” can be on either side of the arrow. In other words the weight of any product can be. calculated, if the weight of any one of the substances is known. 678 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The “x” and the known weight can also be used on the same side of the equation. What weight of hydrogen is required to react with 100 Gms. of iron oxide? 100 x Atomic weights: Fe, (56X2) ;0, (16x3) H,(1 X 2) Formula weights: 112 48 3 X2 Equation weights: 160 6 FG203 -f- 3H2 If 6 grams of hydrogen are required to react with 160 grams of iron oxide, then: 160: 6 :: 100: x 160x = 600 x = 3.75, the number of grams of hydrogen required to react with 100 grams of iron oxide. The weights expressed in the foregoing equations are for 100 per cent, or absolute compounds, which are compounds with absolutely no diluent or im- purities present. Unfortunately such compounds rarely are met with in prac- tice, so that when dealing with actual cases it generally is necessary, after determining the required weights of the absolute substance, to calculate how much of the impure or diluted product at hand will be necessary to furnish the required amount of absolute substance. In dealing with liquids the specific gravity, in addition, must be taken into consideration. Suppose the problem is to determine how many cc of a solution of sulfuric acid, specific gravity 1.90, 90 per cent by weight, will be required to liberate 1,125 Gms. of hydro- chloric acid from the appropriate quantity of sodium chloride. The equation is written and the reacting weights calculated. Using approximate atomic weights, this would be as follows: 117 98 142 73 2NaCl+H2S04-*Na2S04+2HCl which shows that 98 grams of absolute sulfuric acid will produce 73 grams of absolute hydrochloric acid. Then, 98: 73:: x: 1125 and x is found to equal 1,510+ Gms. Now, the specific gravity of the solution of sulfuric acid to be used is 1.90, therefore 1 cc will weigh 1.9 Gms. (volume X sp. gr.=weight), of which 90 per cent, or 1.71 Gms., is absolute sulfuric acid. Then, if 1 cc contains 1.71 Gms. of absolute acid and 1,510 Gms. of the absolute acid are needed, by dividing 1,510 by 1.71 the required number of ec is ascertained, which is, in this case, 883+. It also will be observed that many compounds are crystalline in character, and in these crystals the compounds are combined loosely with one or more molecules of water (water of crystallization), and the weight of this water, though it may be driven off by heating the crystal, must be taken into con- sideration when the crystals themselves are used. The molecular weight of sodium carbonate, for instance, is, in round numbers, 106, but crystals of this compound cannot be indicated always as Na2C03. In one official salt the compound exists as Na-COs.lOELO; therefore to obtain 106 Gms. of the absolute salt in this case it will be necessary to weigh out 286 Gms. of the crystals of that compound. 679 CHEMISTRY Nomenclature and classification of chemical compounds. To be a compound a substance must be composed of atoms of two or more elements which have combined to form molecules or the smallest particles of the substance. Simple molecules (H2, P*) consist of like atoms while compound molecules (H20, KI) are made up of unlike atoms. The naming of chemical compounds depends on a system in which certain accepted terminations are added to the name of one of the elements in the compound. These terminations are considered as meaning that nothing but the elements specifically named is present in the compound. For compounds containing only two elements or one element and a radical the termination ide is used; compounds formed in the union of oxygen, sulfur, chlorine, etc., with another element or radical are known as oxides, sulfides, chlorides, etc., respectively. In addition to this termination there are other ways of distinguishing com- pounds, each of which indicates a compound formed by the combination of ele- ments in different proportions. Copper oxide is the proper designation of both the cuprous and cupric salts of copper, for they contain only two elements, but they are different bodies. Therefore the cuprous salt is designated as copper SM&oxide and the cupric salt as copper monoxide. Sub is used to Indicate a difference in the normal combination of the elements in a salt and in this case there is less oxygen in combination with copper than there is in copper mon- oxide. Mon is but one of the several syllables used to designate the relative quantities of elements which combine in more than one proportion, the others, with examples, being: Carbon dioxide, C02; sulfur trioxide, SOs; carbon tetra- chloride, CCh; and phosphorus pentachloride, PC15, etc. Occasionally a com- pound has one-half more of an element than another compound containing the same elements, or the proportion is as 1 to 1%. But as fractions are not al- lowed in formulas the whole expression is multiplied by two and the proportion becomes as 2 to 3, and such compounds are known as sesqai-compounds, the word sesqui meaning one and a half. The formula of iron-sesquioxide, there- fore, instead of being is FeaOa. Other syllables and terminations used in the naming of compounds will be explained during consideration of acids, bases, and salts (these being the prin- cipal representatives of ternary compounds), those which have been given here being used almost entirely in binary compounds. Binary compounds are compounds containing atoms of two elements, as water, ELO, potassium iodide, KI, or calcium oxide, CaO. Compounds con- taining atoms of three or more different elements are known as ternary com- pounds, as potassium chlorate, KClOa, magnesium sulfate, MgSCb, or sulfuric acid, H2SO4. Ternary compounds are considered as being first derived from binary com- pounds and the negative part of the formula of ternary compounds usually consists of a group of atoms which act in the same manner as the negative element in a binary compound. Thus, in the compounds sulfuric acid, H2SO4, and magnesium sulfate, MgSCh, the hydrogen and magnesium are the metallic or positive parts, and the group SCh acts as the nonmetallic or negative part of the formula. Such groups of elements arc termed radicals and will next be discussed. Radicals are groups or combinations of the atoms of elements that play the part of a single atom in certain types of compounds. They appear in many compounds and although the groups remain intact and act as single atoms in chemical reactions they cannot exist in a free state but are alwaysi found in 680 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY combination with other atoms. One radical, NH4, or ammonium, acts as a positive metal. As explained under valence they are groups of atoms having unsatisfied valence. The valence of radicals is determined by the number of valencies unsatisfied, and is known as saturated, (CH4), monad, (OIL), diad, (CO), etc. With but few exceptions the names of radicals terminate in yl, as carbon yl, methyl, etc., and they are identified in chemical formulas by enclosing them in brackets or parentheses, as (Fe(OH)3, instead of FeOiIL. In addition to being known as a radical such a group of atoms may be known as a residue; that is, what remains after the removal of an atom from a saturated molecule. The formulas, valences, and names of some of the more important radicals are given in the table following. Formula Name Valence Formula Name Valence NH4 Monad. Monad. Monad. CHj Methyl . Monad. Monad. Diad. NOj.. ON OH Hydroxy] CO Although sometimes referred to as radicals, the groups S03 and SO- are really anhydrides, which are compounds derived from acids by the abstraction of a molecule of water. Literally, anhydride means “without water.” The positive radical ammonium, —NH4, cannot exist by itself. When ammonia gas, NH3, is dissolved in water a molecule of it and a molecule of water unite to form ammonium hydroxide, NELOH. Chemically, ammonia is nitrogen trihydride, and as such the nitrogen must have a valence of III. When brought in contact with water the nitrogen is theoretically considered to be oxidized to its maximum valence, Y, with which it can hold the four hydrogen atoms and one hydroxyl group. This hydroxyl group can be exchanged for other radicals similarly, as though it were attached to a single positive element. The formation of ammonium hydroxide is shown graphically as follows; (Nitrogm/trihydride)} Water Ammonium hydroxide The univalent hydroxyl radical, —OH, consisting of one atom of hydrogen and oxygen, cannot exist by itself, and is a characteristic part of bases, alcohols, oxyacids, etc. Radicals play a most important part in the various reactions of analytic and synthetic chemistry, readily interchanging with atoms in chemical reactions. Radicals are so closely interwoven in the theories and laws concerning the formation of acids, bases, and salts that consideration of them will be continued in the discussion of the latter. Acids, bases, and salts are the three main types of inorganic chemical com- pounds and any one of the three may be either a binary or ternary compound. Acids are compounds of hydrogen with a negative element or radical, and are sometimes considered as salts of hydrogen. They possess a sour taste when diluted, saturate bases (neutralization), destroy or change the color of litmus CHEMISTRY 681 or other indicators, have a corrosive action on animal and vegetable tissues, and in aqueous solution dissociate into hydrogen ions, producing the characteristic reaction of the substance, and electronegative elements. All acids contain hydro- gen which is readily replaceable by a metal, the product being a salt. Acids are divided into two classes, binary (hydrogen, hydro, or halogen) acids which are compounds of the halogens and hydrogen, and ternary (oxy or oxygen) acids in which hydrogen is linked by means of oxygen to negative radicals containing oxygen, as HO—NO2. Examples of each are shown in the table following. Hydrogen acids Oxygen acids Hydrochloric acid .. HC1 Hydrobromicacid ..... HBr Hydriodic acid HI Hydrofluoric acid.. HF Sulfuric acid _ ... .. H2SO1 Nitric acid HNO3 Phosphoric acid.. .. HsPO* Carbonic acid IHCOj Chloric acid HCIO3 The strength of an acid is said to depend upon the degree to which it can dissociate or ionize. When an oxide of a negative element is dissolved in water an acid is produced. Theoretically, then, in order to manufacture an acid the first step is to produce an oxide of the element. Such an oxide is known as an acid anhydride, which may be described as an acid from which all hydrogen with sufficient oxygen to form water has been removed. For purposes of nomenclature all ternary acids are considered to be derived from acid anhydrides. A molecule of an acid may be said to be composed of two parts—its replace- able hydrogen and the remainder of the molecule. This remainder is known as an acid radical or residue. If an acid contains one atom of hydrogen to a molecule, as does hydrochloric acid, one atom of any univalent or monovalent element may replace that hydrogen to form a normal salt, but as an atom of a divalent element is equivalent in strength, or valence, to two hydrogen atoms one divalent atom can replace the hydrogen contained in two molecules of such an acid. Conversely, if the acid contains two atoms of replaceable hydrogen to a molecule, as sulfuric acid, it is evident that it must require two atoms of a univalent or monovalent element, or one atom of a divalent element to replace it. For that reason radicals are regarded as groups not broken up easily, which act as a unit in most reactions, and which possess valence (or basicity) the same as do elements, this basicity being determined by the num- ber of replaceable hydrogen atoms in a molecule of the acid of which they are the residue; for example: depend upon the degree to which it can Acid Radical Basicity HN03. . -N03 ... 1 HCIO3 — ClOa 1 H2CO3 = C03 2 =so4 2 H3PO4 =P04. 3 =bo3 3 The formula for a radical may be written correctly and no attention paid to the valence of any particular element in it, since these elements are acting as a group, or whole, and, as stated before, the valence or basicity of the radical or group is governed solely by the number of replaceable hydrogen atoms orig- 682 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY inally combined with them in the acid of which they are the residue. Observ- ing the matter in this light, it is clear that by knowing the valence of the base to be used and the formula of the acid from which the radical is derived, the two then may be combined exactly in the same manner as would be two ele- ments to form any binary compound. For example, it is desired to write the formula for zinc carbonate. Zinc has a valence of two. Its symbol, Zn, is written down. A carbonate must come from carbonic acid, since carbon is the characteristic element in that radical and “ate” salts come from “ic” acids. The formula for carbonic acid is H2CO3. The carbonate radical therefore must be COs and is written down alongside and next after the symbol for zinc. Car- bonic acid, containing two atoms of replaceable hydrogen to a molecule, shows that the carbonate radical must be dibasic and accordingly will exactly match in valence strength with one atom of zinc. The formula for zinc carbonate therefore is ZnCOs. In other words, zinc being divalent, is equal in combining power to two hydrogen atoms and can replace them in any acid. Sodium is univalent, and it would require two atoms of that element to replace all the hydrogen in a molecule of carbonic acid, so that the formula for sodium car- bonate would be Na2C03. Whenever a whole radical must be used in a formula more than one time (unless it is a binary radical) it is necessary to enclose it within parentheses and multiply it by using a small numeral suffixed somewhat below the parentheses, as is done in the case of multiplying a single atom. For example— Calcium chlorate Ca(C103)2 Ferric sulfate Fe2(S04)3 Ferrous phosphate Fe3(P04)2 Carbonate radicals generally are broken up when brought in contact with an acid or when heated, and therefore when a carbonate reacts with an acid another carbonate is not formed, but carbon dioxide and water are among the products. This is shown by the equation marked (a) following. When heated, all carbonates except those of the alkalies will produce carbon dioxide and an oxide of the element with which it is combined as a carbonate, as shown by the equation marked (&). (а) CaC03+H2S04->CaS04+C02+H20 (б) CaCOs+Heat—>Ca0+C02 Very few salts are actually formed by treating a metal or its base with an acid, although practically all of them can be so produced. Many of the acids do not exist as such, and others, though formation is possible, are of such a weak or unstable nature that their use outside of a laboratory would be most impracticable, and in most instances formation of salts by such a method would prove too costly. In practice, therefore, compounds are produced usually by other methods, an outline of which will be given later. Most of the acid-forming elements are polyvalent, and therefore they can unite with oxygen to produce more than one oxide. In the cases of those elements which form only two oxides, as nitrogen or arsenic, the nomenclature is easy and is carried out exactly as described for all binary compounds; that is, there would be nitrous and nitric oxides and arsenic and arsenious oxides. In examining chlorine it will be seen that this element possesses four distinct sets of valences, and therefore can unite with oxygen in four ways. It develops that chlorine, as well as others of these polyvalent elements, has two sets of valences with which it unites with oxygen much more often than it does with its other two sets. Also that these more common compounds with oxygen are much more stable. To the compounds formed by these two sets of CHEMISTRY 683 valences the endings ic and ous are given. Thus there are chloric oxide (CI2O5) and chlorous oxide (CI2O3), in which the valence of chlorine is V and III, respectively. For the oxides next above the ic form the prefix per is used, and for the oxide next below the ous form the prefix hypo. Accordingly the oxides of chlorine are named as follows: Perchloric oxide, chloric oxide, chlorous oxide, and hypochlorous oxide. Such oxides also may be named in other ways; for example, chloric oxide correctly may be called chloric oxide, chlorine pentoxide, or chloric anhydride. As has been said, an acid is produced by dissolving a negative oxide (acid anhydride) in water, and the acid so produced inherits the name of the oxide, the word “acid” simply being substituted for the word “oxide”; therefore sulfuric oxide produces sulfuric acid, nitric oxide produces nitric acid, and hypophosphorous oxide produces hypophosphorous acid, and chloric, iodic, and bromic acids are derived, respectively, from chloric, iodic, and bromic an- hydrides. The negative element which unites with oxygen to form an acid anhydride is known as the “characteristic” element of that oxide and of the acid produced from it. It is the element that gives the acid its name; e. g., sulfur is the characteristic element in sulfuric acid, etc. The reaction that actually occurs when an anhydride is dissolved in water is that the molecule of the anhydride unites with the molecule of the water to form one or more hydroxyl groups, so that, if lines are used to designate valence or bonds, the transformation that takes place is as shown in the following graphic formula of sulfuric acid: Sulfuric anhydride Sulfuric trioxide + Water yields Sulfuric acid S03 + H20 H2S04 It should be noted that it is only the hydrogen contained in the hydroxyl group of a ternary acid that can be replaced by a metal or a base. Usually in all inorganic acids all of the hydrogen is so combined but not always. The formula for phosphorous acid is H3PO3, but only two of the hydrogen atoms can be replaced for the reason that only two are contained in hydroxyl groups, as is shown by the graphic formula of that acid: Phosphorous acid Experiments have proven that hydrogen not so contained is not replaceable by a positive element, and as phosphorous acid contains hydrogen that is not part of a hydroxyl group it is therefore one in which all of the hydrogen cannot be replaced. (Some authorities question the graphic formula of phosphorous acid as shown.) Acids are also classed according to their basicity, which is determined by the number of hydrogen atoms they contain that are replaceable by monovalent positive atoms. Acids having one replaceable hydrogen atom, as hydrochloric (HC1), are known as monobasic, those with two, as sulfuric (H2SO4), as dibasic, h3po3 154294°-—89 44 684 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY those with three, as phosphoric (HsPCb), as tribasic, etc. Any acid containing more than one replaceable hydrogen atom may be termed a polybasic acid. Tables showing examples of the two classes of inorganic acids are given next. Binary or Hydracids Name Formula Name Formula Name Formula Hydrobromic- HBr Hydrocyanic HCN Hydriodic- HI Hydrochloric _ _ HC1 Hydrofluoric HF Hydrosulfuric. II2S These acids form salts whose names terminate in the ending ide and the prefix hydro is not used in naming the salt. Thus hydrochloric acid produces chlorides and hydrosulfuric acid produces sulfides. Ternary or Oxyacids Name Formula Name Formula Name Formula HCIO4 H2S2O7 HC1O3 Sulfuric . H2SO4 HBrO HCIO2 H2S2O3 HCIO Sulfurous . . ... H2SO3 HIOs H2S2O4 HNOs Pyrophosphoric H4P2O7 HNO2 HsPOi IIB02 H4S104 HPOs H3PO2 Cyanic . HCNO Salts formed by these acids are named as follows: Acids whose names end in ic produce salts whose names end in ate; acids whose names end in ons pro- duce salts whose names end in ite and any prefix occurring in the name of the acid before the part referring to the “characteristic” element also is used in the name of the salt. Thus sulfuric acid produces sulfates, sulfurous acid produces sulfites, and persulfuric acid produces persulfates. Some of these acids may not actually exist and some are' so unstable that their actual use, outside a laboratory, would be impracticable, but salts of all of them are existent. The formulas given in these tables are molecular formulas in that they express the content, qualitatively and quantitatively, of a molecule. Bases are compounds in which a positive element or radical is united with a hydroxyl (—OH) group. They are capable of reacting with acids to form salts, and when dissolved in water they dissociate, yielding hydroxyl ions, which produce their characteristic alkaline reaction, and electropositive ele- ments. Because they contain the hydroxyl group they are also known as hydroxides. Hydroxides of the alkali-metals are called alkalis, while those of calcium, strontium, barium, and magnesium are called alkaline earths. Alkalis are known as mild and caustic, according to the strength of their action. Bases have several characteristic properties such as: Interaction with acids to form salts; alkaline reaction, if soluble; restoration of the blue color of substances reddened by acids, as litmus; soapy, slippery feeling, if soluble; power to saturate or neutralize acids, taking away their characteristic proper- ties; and the effervescence of most mild varieties with acids, giving off carbon dioxide (C02). CHEMISTRY 685 In theory, for purposes of nomenclature, bases are regarded as being formed either by the direct union of some basic element and oxygen, as calcium oxide, CaO, or by the action of a positive element or its oxide on water, where- by a hydroxide is formed, as potassium hydroxide, KOH. A hydroxide is a compound in which an atom of an element is combined with one or more groups of hydroxyl (—OH). Being a radical, hydroxyl cannot exist by itself, and when combined as a hydroxide it may he regarded as water in which one of the hydrogen atoms has been replaced by another element. Hydroxides are regarded as binary compounds, as the group (—OH) acts much the same as a univalent element. Hydroxides must not be confused with hydrates. The latter are additive compounds of one or more whole molecules of water with a molecule of some other compound, such as, for instance, terpin hydrate (C10H20O2.H2O). When acids are mixed with bases mutual rearrangements of the composi- tions of these substances take place, and the products of this interaction between acids and bases are known as salts. This term should not be confused with the common name of sodium chloride, “salt.” The saturating or neutralizing power of bases is determined by the number of hydroxyl groups present. When one hydroxyl group is present a base is known as mon&hydric (sodium hydroxide, NaOH) ; when two are present a base is known as dihydric (barium hydroxide, Ba(OH)2) ; etc. Salts are the products or compounds formed when all or part of the replace- able hydrogen in an acid has been replaced by a positive element or a base. They are classified according to the amounts of the acids and bases entering into the interaction, being known as normal or neutral, acid or mixed, double, and basic or oxy or sub. Normal or neutral salts are those in which all replaceable hydrogen of an acid has been replaced by a metal or base, as in calcium sulfate (CaSCh). Acid salts are those in which the amount of the base is not sufficient to allow complete interaction and only a part of the replaceable hydrogen of the acid can be replaced by a metal or base, as sodium acid sulfate (NaHSCh). Be- cause of the presence of this unreplaceable hydrogen, the names of acid salts usually contain the word acid and their formulas always contain an H. They also are designated as hydrogen salts or, instead of using the word acid or hydrogen in their names, the prefix “bi” may be used, and when so used always denotes an acid salt. Its use in any other kind of compound is incorrect, and therefore should never be used in place of “di” to indicate a double quantity. Bichloride of mercury is an example of the incorrect use of this word. Sodium acid sulfate, then, correctly may be called by that name or sodium hydrogen sulfate or sodium bisulfate. Double salts are those in which the hydrogen of an acid has been replaced by two or more elements, as in sodium and potassium sulfate, NaKSCh, or by an element and a radical, as in sodium ammonium sulfate, NaNIBSCh. Basic salts are those which contain more base than is required to form a normal salt and are regarded generally as being formed when there is not enough acid present to neutralize the base. An example of a basic salt is bis- muth subnitrate or, as it is sometimes called, bismuth oxynitrate. This basic salt is prepared by the decomposition of bismuth nitrate in a large quantity -of water according to the following interaction: Bi(N03)3 +2H20 BiO(NOs) .H20 + 2HNO-, Bismuth nitrate-f Water gives Bismuth subnitrate-{-Nitric acid 686 HANDBOOK OF THE HOSPITAL CORPS, XT. S. NAVY In the interaction shown it might seem that there was sufficient nitric acid present to neutralize the base (a metal in this case) but immediately water is added to the normal salt (bismuth nitrate), two of the acid anhydrides (NOs) in it combine with two of the hydrogen atoms in the water to form nitric acid, so it can be seen that there is not enough acid (NOs) present in bismuth subnitrate to neutralize the base, the base bismuth having a valence of 3 while the valence of the acid anhydride is but 1. Just as the acids are named from the anhydrides from which they are derived, so, too, are salts named from the acid which produces them, by naming the first or basic part of the salt just as described for the basic part of binary salts and dropping the ending of the names of the acid and substituting other endings. As the salt of a binary acid is itself a binary compound its name must end in “ide” so that from a reaction of zinc and hydrochloric acid would be obtained zinc chloride. The names of all ternary acids, as has been learned, end either in “ous” or “ic” and the names of the salts from these acids end in “ite” or “ate” respectively. In all salts, except binaries, any prefix the acid may have had is carried over and incorporated in the name of the salt. Thus it may be said that “ous” acids produce “ite” salts, “ic” acids produce “ate” salts, “per-ic” acids produce “per-ate” salts, “hypo-ous” acids produce “hypo- ite” salts, and “meta-ic” acids produce “meta-ate” salts. Similarly, any other prefix the name of a specific acid may have is inherited by any salt it may produce, as, for instance, pyrophosphoric acid produces pyrophosphates. All rules are tested by the exceptions thereto, and it must not be inferred from anything that has been said that in all instances the facts will adhere rigidly to the theory laid down. The scheme of nomenclature for acids and salts herein described is conceived as the one most nearly fitting all cases. It is purely theoretical and conceives that all acids are formed from their respective anhydrides, as described, and further, that all salts are derived directly through the action of an acid on a positive element, or upon an oxide or hydroxide of a positive element (bases). For the reason that ternary acids are produced from binary compounds and all other ternary compounds in turn are derived from the acids, in order to determine the formula of any salt, it is necessary that the formula of every acid listed in the tables of inorganic acids on page 684 be committed to memory. Just as it is necessary to know the valences of the different elements before it is possible to accurately write the correct formula for any acids, so is it necessary to know these formulas before it will be possible to write the formula of any compound (salt) derived from them. The nonmetals. Hydrogen.—Symbol: H ; Atomic number : 1; Atomic weight; 1.0078 ; Valence : I; Molecular formula : H2. Occurrence: Hydrogen is one of the most widely distributed elements. It forms one-ninth of the water of the earth, one one-hundredth per cent of the air, and is a constituent of nearly all organic material. Properties: Pure hydrogen is an odorless, colorless, tasteless gas. It is the lightest substance known, one liter weighing 0.089783 Gm. at 0° C. and 760 mm. pressure. Because of this property “lighter-than-air” aircraft are inflated with it to give them buoyancy, but due to its inflammable nature its use for that purpose is extremely hazardous. Inasmuch as its molecules have great diffusi- bility nonporous containers are necessary to retain it. Because of its activity in the nascent state, i. e., when being liberated from its compounds in the form of atoms, two atoms of hydrogen combine to form CHEMISTRY 687 a stable molecule. In this form it has little affinity for other substances, but in the nascent state or when its temperature is elevated, its behavior is quite the opposite. It bums with a nonluminous but intensely hot flame, combining with the oxygen of air to form water. This intense heat is put to practical use in the oxy-hydrogen torch employed to weld metals having a high melting point. When a current of hydrogen is directed upon a mass of finely divided plat- Figure 152.—Generation of hydrogen gas: (a) Generator; (6) wash bottle; (c) thistle tube ; (d) outlet. inum, the latter becomes incandescent. This results from the heat produced by the union of hydrogen with the oxygen occluded (absorbed) in the finely divided metal. The platinum undergoes no chemical change. Other metals and substances act in a similar manner, facilitating a chemical reaction with- out undergoing any chemical change themselves. These substances which accelerate such chemical reaction through their presence are known as catalysts and the action is termed catalysis. Hydrogen combines with chlorine even more readily than with oxygen, but with most other nonmetals it does not unite unless in a nascent state. The 688 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY nascent state represents the element in its atomic condition at the moment of generation. While in the nascent state hydrogen is capable of reducing ic compounds to lower ous compounds, or metallic oxides and chlorides to their metals: 2FeCl3 + H2—>2FeCl2 + 2HC1 Fe203 3H2—>3H20 -f- 2Fe Isolation.—Hydrogen may be prepared by the electrolysis of acidified water, 2H20-^2H2+Ou> or by the action of dilute acids upon a metal, the gas being collected over water (fig. 152) : Zn+H2S04-*ZnS04+H21 When the zinc is brought into contact with the acid solution an equivalent weight of the metal passes into solution in the ionic condition. The hydrogen ions recover their missing electron from the zinc atoms and are liberated as molecular (gaseous) hydrogen. This giving up of an electron by the metallic atoms shows that they have a smaller affinity for their electrons than does hydrogen. The reaction of the metal and the acid is attended by the evolution of considerable heat and experiments have shown that the heat evolved when various metals are used is quite different, which shows that the “chemical activity” of the metals is different. Some metals, like sodium, react vigorously with water at ordinary temper- atures displacing hydrogen, while others, like iron, must be heated before the hydrogen is displaced. This is because sodium is more active than iron, and the same difference exists when they are brought in contact with an acid. As a result of this difference in chemical activity it has been found that certain metals will displace others in acid solutions and it is possible to arrange all the metals in the order in which they will displace each other in this way. Such an arrangement is known as the electrochemical series of the metals, and also as the electromotive series. Following is a list of the common metals showing their position in the electrochemical series according to their decreasing chemical activity. Lithium Aluminum Nickel Copper Potassium, Manganese Tin Mercury Sodium Zinc Lead Silver Strontium Chromium HYDROGEN Platinum Barium Iron Antimony Gold Calcium Cadmium Bismuth Magnesium Cobalt Arsenic All the metals above a given one in this list will displace it from solutions of its compounds, while it, in turn, will displace all those of lower position. Sodium and potassium react violently with water at room temperature; mag- nesium burns in steam while iron must be heated before it reacts with steam; and the metals below iron do not react with steam unless excessive tempera- tures are employed. The place of hydrogen in the electrochemical series is most interesting. All those metals which precede it will, under ordinary conditions, evolve hydrogen from dilute acids, while those which follow it will not. CHEMISTRY 689 All the metals down to and including mercury combine directly with oxygen, while the oxides of gold and platinum are formed indirectly. If the oxides of the first ten metals are heated in hydrogen no reduction takes place, but those oxides from iron to copper inclusive are reduced by heating with hydrogen. The oxides of the last four metals are reduced by heat alone. The Chlorine Family ok “Halogens”.—Chlorine, bromine, iodine and fluorine exhibit such a close resemblance as elements, and in their compounds, that they are grouped into a family known as halogens or “salt formers.” They all unite with metals to form salts such as sodium chloride. chlorine.-—Symbol: Cl; Atomic number: 17; Atomic weight: 35.457; Valence: I; Molecular formula : Cl2. Occurrence.—In Nature chlorine does not occur free but is found abundantly in combination with sodium in sea-water and salt mines. It is not very abundant in the vegetable kingdom, but in the animal kingdom, combined with sodium, it is a constituent of the body fluids. Proper'ties.—Chlorine is a yellowish-green gas with a suffocating odor and when inhaled has a corrosive effect on the mucous membrane of the respira- tory tract. Next to fluorine, chlorine is the most active element of the non- metal group, readily combining with all the elements except oxygen, the inert gases and some of the rarer metals. A mixture of chlorine and hydrogen com- bines with explosive violence when a flame or spark is applied, upon contact with a platinum sponge, or upon exposure to the sun’s rays. Because of its intense affinity for hydrogen, chlorine indirectly becomes a powerful oxidizing agent by liberating nascent oxygen from the water in moistened materials. Isolation.—Chlorine may be isolated by the electrolysis of HOI or chlorides, or through the oxidation of HC1 by higher metallic oxides with the application of moderate heat: 2HC1-»IL+C12 It is extensively used as a bleaching agent in the form of chlorinated lime and is employed in water purification and sewage disposal as a powerful germicide and deodorizer. Chlorine was the first gas used in modern chemical warfare, and has a demoralizing effect upon troops because of its irritant, suf- focating action. Prior to the development of efficient masks it caused heavy casualties. Hydrochloric acid, HC1, is one of the gaseous products ejected from volcanoes and is a normal constituent of the gastric juices of mammals, being present in quantities from 0.1 to 0.4 per cent. It is a colorless gas with a sharp, suffocat- ing odor and acid taste. The dry gas neither acts on metals nor reddens litmus. It fumes in moist air and is very soluble in water. In contact with most metallic oxides it decomposes them to form water and a chloride: Mn02+4HC1—»MnCU+2HjO+Cla Fe203+6HCl->2FeCl3+3H20 The concentrated aqueous solution, commonly called muriatic acid and con- taining 35 to 37 per cent HC1, is a colorless, corrosive fluid with a strong acid taste and pungent odor. Most metals dissolve in it, liberating hydrogen. Certain typical reactions are produced by strong acids acting upon various substances, and examples of them are shown in the following equations in which HC1 is the strong acid used: 690 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 1. Metals are acted upon by acids, hydrogen being displaced and a salt formed: 2HC1+Fe—> FeCh+Ha T 2. Acids react with oxides of the metallic elements, a salt and water being formed: Fe0+2HC1—»FeCl2+H20 3. Acids react with metallic hydroxides to form a salt and water: Fe(0H)2+2HCl-»FeCl2+2H20 4. An acid reacts with a carbonate to form a new salt and water, with the liberation of carbon dioxide: FeC03+2HC1 —> FeCl2+H20+C02 T (H,CO.) 5. In general there is a tendency for the active acids to react with metallic salts, liberating the acid of the salt and forming a new salt: bromine.—Symbol; Br; Atomic number: 35; Atomic weight: 79.916; Valence: I; Molecular formula : Br2. Occurrence.—The chief sources of bromine are from magnesium bromide in brine wells and in sea-water. The magnesium, calcium, and sodium salts of bromine are found in many rock salt deposits. Properties.—Bromine is a reddish-brown, intensely caustic liquid which lib- erates orange-red vapors of a suffocating odor resembling that of chlorine. It is similar to chlorine in chemical action, although less active, chlorine displac- ing bromine from salts. In the presence of water it is an active oxidizing agent: FeS04+2HC]->H2S04+FeCl2 H2 S+4Br2+4H20-+ H2SO*+8HBr Isolation.—The various methods employed for the isolation of bromine depend upon its displacement from bromine salts by chlorine: Cl2+2NaBr—»2NaCl+Br2 Hydrolromic acid, HBr, is a colorless, heavy gas, with a sharp, irritating odor and acid taste; it is very soluble in water, the concentrated solution fuming in air. Solutions of the acid decompose upon standing, bromine being liberated. It combines with most metals to form salts, called bromides, which are used extensively in medicine and photography: NaOH+HBr —>NaBr+H20 Hydrobromic acid is prepared by the action of an acid upon a bromide; Sulfuric acid cannot be used due to the liberation of sulfur dioxide and molecular bromine. iodine.—Symbol: I; Atomic number: 53; Atomic weight: 126.92; Valence: I; Molecular formula: I2. Occurrence.-—In small quantities, iodine is distributed throughout Nature combined with sodium, potassium, calcium, and magnesium. In sea-water, iodides are absorbed by sea-weeds, known as kelp, and certain species of sponges, which formerly comprised the chief source. Most of the present world supply is obtained from the iodate impurities of salpeter found in Chile and 3KBr+H3P04-> K3P04+3HBr CHEMISTRY 691 Peru. Traces of iodine are found in the blood and certain portions of the animal body, as the thyroid and the liver. Properties.—The bluish-black rhombic plaques of pure iodine have a metallic luster, distinctive odor, acrid taste and neutral reaction. Iodine is slightly soluble in water, but in the presence of alkali iodides or hydriodic acid its solubility is greatly increased. One Gm. is soluble in 12.5 parts of alcohol. It resembles chlorine and bromine in its chemical reactions, although it is less active. Its affinity for hydrogen is comparatively weak, but the reverse is true in its relation to oxygen, for chlorine and bromine are replaced in their oxygen compounds by iodine: 2KC10,-!+I,-* 2KI03+Cl2 Iodine unites with the positive element in a solution of alkali hydroxides to form iodides and iodates: 3l2+6NaOH-^5NaI+NaI03+3H20 Upon treatment with ammonia water, it forms a very explosive compound, nitrogen tri-iodide (NL). Isolation.—Iodine is extracted from Chilean saltpeter by precipitation from the mother liquor (after the removal of the sodium nitrate) with a mixture of acid and neutral sodium sulfite: 2NaI03+3Na2S03+2NaHS03-^5Na2S04+H20+I2 The precipitate is collected on muslin, strained, dried, and purified by sublimation. Iodine and its salts are used extensively in medicine and photography. Hydriodic acid, HI, is a colorless, heavy gas with a sharp penetrating odor, fuming in air and very soluble in water. This is a very unstable compound, decomposing upon exposure to air. As a reducing agent it is very active due to the readiness with which it resolves into iodine and nascent hydrogen; hence, it is employed extensively in organic synthesis. It may be prepared by the action of phosphoric acid upon potassium iodide with the application of heat: Most of the compounds known as iodides are very soluble in water and may be prepared by the direct union of the elements in water: 3KI+H3P04—^PCX+SHI or by the addition of iodine to the hydroxide of an alkali metal: Fe+Ia— 3l2+6KOH-> 5KI+KI03+3H20 The mass is then burned with charcoal to reduce the iodate: KIOs+SC—>KI+3C0 Fluorine.—Symbol: F ; Atomic number : 9; Atomic weight: 19.00; Valence I; Molecular formula: F2. Occurrence.—Fluorine occurs mainly as calcium fluoride (fluorspar), CaF2, widely distributed throughout the world, and as sodium and aluminum fluoride (cryolite), BNaF.AlFs, found in Greenland. Properties.—Fluorine is the most active element known, combining with hydrogen even in the dark with explosive violence, and decomposing water with the formation of hydrogen fluoride and ozone. Many organic substances are ignited upon contact with it. 692 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Isolation.—It is prepared by the electrolysis of anhydrous hydrofluoric acid. Hydrofluoric acid, anhydrous, HF, is a colorless liquid which vaporizes as an intense, irritating, corrosive gas. In the presence of water it corrodes glass, porcelain, earthenware and most of the metals, but has slight effect upon the nonmetals. Its action upon silica makes it very useful in etching glassware. The gaseous envelope which surrounds the earth is called the atmosphere. It is composed of: Percent Nitrogen (N) 78 Oxygen (O) 21 Argon (A) 00.94 Carbon dioxide (CO2) 00.03 Hydrogen (H) 00.01 Neon (Ne) Helium (He) Krypton (Kr) Xenon (Xe) Niton (Nt) 00. 02 Except for carbon dioxide, these elements as found in the atmosphere are in a free and uncombined state, so that air is a mixture. Helium, neon, argon, krypton, xenon, and niton are completely inactive, uniting with no known substance or element to form compounds and having only one atom in their molecules. They are the so-called inert gases, existing only in the atomic state. Oxygen.—Symbol: O ; Atomic number: 8; Atomic weight: 16.00; Valence II; Molecular formula: Ch. The discoverer of this element is regarded as Joseph Priestley of England who in 1774 obtained an “air”, as he called it, from the heating of mercuric oxide over mercury in which he found “that a candle burned * * * with a remarkably brilliant flame.” Although it is certain that Scheele of Sweden had isolated this gas in 1772 and there is little doubt that other experimenters had obtained oxygen long before either Scheele or Priestley, credit for its discovery is given to Priestley because he was the first to publish the results of his experiments and make them known to the world. Lavoisier of France, with whom begins modern chemistry, developed experiments showing its source and properties and in 1784, because he thought the properties of acids were due to the presence in them of this substance, he gave it the name of oxygen, which is derived from Greek words meaning “sour” and “I produce,” or roughly, “acid former,” sourness being a characteristic of acids. Oxygen is the most useful element known to man and is essential to animal life in the repair of tissues and the furnishing of heat and energy. It is vital in developing heat, light, and power from burning fuel. It is used in the acetylene torch, in special high-temperature furnaces and in treating respiratory distress from pneumonia, heart disease, and severe asthma. Submarine opera- tions, diving, caisson work, high-altitude flying and rescue-breathing apparatus all require oxygen. It is mixed with anaesthetic gases in the production of general anaesthesia. Occurrence.—Oxygen makes up one-half of all matter known to man, eight- ninths of the water of the ocean, and, more than one-fifth of the atmosphere. Two-thirds of the human body is combined oxygen. Ordinary soil and rocks contain about 50 per cent oxygen. It occurs free only in the air, its most natural and cheapest source. CHEMISTRY 693 Properties.—Oxygen is a colorless, odorless, tasteless gas which is 1.105 times as heavy as air. One liter weighs 1.429 Gm. measured at 0° C. and a barometric pressure of 760 mm. It may be liquefied at and below minus 118° C., but no pressure is great enough to compress it to a liquid above minus 118° 0. which may then be called its critical temperature. At this critical temperature a pressure of 50 atmospheres is required to liquefy oxygen, and hence is called the critical pressure. Liquid oxygen is light blue in color and boils at minus 182.5° 0. under atmos- pheric pressure. Frozen oxygen is a pale blue, snowlike solid, melting at minus 227° O. It is only slightly soluble in water, 30 ec per liter. While oxygen is only moderately active at ordinary temperatures, it is very active at elevated temperatures and unites with all the elements except fluorine and the inert gases. Iron will rust in the air at ordinary temperatures but when heated red hot and placed in oxygen, will actually burn: 3Fe+20a—> FeO.Fe2Os A compound of oxygen with an element or radical is termed an oxide. Accord- ing to their observed composition they are known as monoxides (R-O), and (RO), sesquioxides (R/h), dioxides (R02), trioxides (RO..) tetmoxides (ROi), pent oxides (JB205), and heptoxides (K207), R in these formulas representing any element. Oxides are divided into two general classes according to the nature of the compounds resulting from their union with water. Oxides yielding acids with water are called acidic oxides, and those yielding bases with water are called basic oxides. Acidic oxides, also called acid anhydrides, combine with basic oxides to form salts, as sulfur trioxide (SOs) which combines with barium oxide (BaO) to form barium sulfate (BaSO*). Basic oxides unite with acids and acidic oxides to form salts, as copper oxide (CuO) unites with diluted sulfuric acid (H2SO4) to form copper sulfate (CuSOO, and sodium oxide (Na20) unites with sulfur trioxide (SOs) to form sodium sulfate (Na2SO.i). Oxides consisting of a metallic element and oxygen are known as metallic oxides, and those that do not form acids with water, that cannot be obtained by removing water from acids, and that do not form salts by uniting with either basic or acidic oxides or with acids are known as neutral oxides. Oxides that combine with acids to form salts corresponding with oxides con- taining less oxygen than they do themselves are termed peroxides, as hydrogen dioxide (H2O2) and barium dioxide (Ba02). Elements whose oxides react with water to form bases are called metals and elements whose oxides react with water to form acids are called nonmetals. When substances react, heat is usually liberated and if this reaction becomes vigorous enough to produce light it is called combustion. As a rule this term is applied to a union of oxygen with other substances. The temperature at which a substance in contact with air bursts into flame is called its Mndling temperature. Reactions accompanied by heat are exothermic and those requir- ing the application of external heat to keep them going are endothermic. The unit of measure for heat is the calorie which is the amount of heat required to raise the temperature of 1 Gm. of water from zero to 1° C. The British thermal unit (B. T. U.) is the amount of heat required to raise the temperature of 1 pound of water 1° F. Since 1 pound contains 453 Gm. and 1° F. is five-ninths of 1° C., the B. T. U.=% of 453 or 252 calories. The number of calories liberated when the formula weight (molecular weight in 694 HANDBOOK OF THE HOSPITAL CORPS, XT. S. NAVY grams) of any pure substance burns completely is the heat of combustion. When a gram of substance oxidizes slowly it liberates the same amount of heat as when it burns violently. If the heat from a slow oxidation is not conducted away fast enough it accumulates, finally bringing the temperature of the substance to the ignition point. This is called spontaneous combustion. Oil-soaked rags are most likely to ignite spontaneously and should be disposed of or placed in closed tin cans. Isolation.—To obtain oxygen air is liquefied by pressure under reduced temperature and then allowed to evaporate. The more volatile nitrogen evaporates first and leaves the oxygen which is pumped into strong cylinders. Electrolysis of water releases oxygen and hydrogen at the anode and cathode electrodes respectively but this method is expensive. The heating of oxygen compounds is the most convenient laboratory method: 2HgO + Heat -» 2Hg -f O2 T Mercuric oxide Mercury Oxygen 2KN03 + Heat -» 2KN02 + O2 t Potassium nitrate Potassium nitrite Oxygen 3MnOa + Heat —> Mn30* + 02 T Manganese dioxide Manganese oxide Oxygen 2Ba02 + Heat -> 2BaO + 02 T Barium dioxide Barium monoxide Oxygen 2KC103 + Heat -► 2KC1 + 302 T Potassium chlorate Potassium chloride Oxygen The last reaction shown is much more complete and rapid, even at a rela- tively low temperature, when a small amount of manganese dioxide is present. The manganese dioxide aids the reaction without entering into the chemical changes and is therefore a catalyst. The oxygen is collected by displacement of water in inverted containers. When an element exists in more than one form in the same physical state these forms are said to be allotropic modifications of the element, and the condition is known as allotropism. This condition is found in several of the elements, one of them being oxygen, the allotropic form of which is ozone, (Os), with distinct physical properties. Ozone is 1.5 times as heavy as oxygen and more active chemically. It is formed in the upper atmosphere by ultra-violet radiation. Static electrical discharges, lightning, static machines, and electric motors produce it from the oxygen of the air. The change from oxygen to ozone is represented thus: It has a characteristic pungent odor and is rather unstable, tend- ing to turn to oxygen. Its oxidation is done with the third atom releas- ing O2. Thus: H2S+O3—HI20+S+02. Formerly its chief use was as a bleaching agent and water purifier but now it has been largely replaced by chlorine. Produced electrically it is very effective as a deodorizing agent in homes, restau- rants and theatres. Ozone is claimed to be healthful and stimulating. Water, H20, is the most important of all chemical compounds. It occupies about five-sevenths of the earth’s surface as lakes, rivers, and oceans; as ice and snow it covers the vast arctic and antarctic regions. In addition to its abundant natural occurrence, water is present in green plants to the extent of 75 per cent to 80 per cent and in the soil from 5 per cent to 20 per cent. CHEMISTRY 695 It exists in considerable quantities in the atmosphere from which it is pre- cipitated in various forms. Pure water is an odorless and tasteless liquid. In small quantities it is colorless, but with an increase in depth it assumes a bluish-green color. When cooled, water contracts, reaching its maximum density at 4° C. at which temper- ature 1 cc has a weight of 1 Gm. At 0° C. it solidifies, forming ice. The freezing point may vary slightly under certain circumstances, but the melting point remains constant at 0° C. At 100° C. water boils, forming steam. These figures are determined at a pressure of 760 mm. of mercury. Water evaporates constantly and the higher the temperature, the faster the rate. Increased pressure and vapor tension reduce the rate of evaporation. If a little water or any other liquid is introduced into the vacuum of a mercury barometer, its molecules immediately begin to saturate the space with vapor, depressing the mercury column according to the temperature of the tube. If the height of the mercury column is subtracted from the true baro- metric reading, taken at the same temperature, the vapor tension of the liquid is obtained. At 0° C. water has a vapor tension of 4.6 mm. of mercury; at 100° C. it has a vapor tension of 760 mm. of mercury; that is, the vapor tension equals the atmospheric pressure. When this condition prevails, the water boils because the molecules can escape freely from the liquid. The boiling point of a liquid is attained when its vapor tension just exceeds the pressure of the surrounding atmosphere. The importance of water is due largely to its capability of dissolving many substances, chemical reactions taking place readily in solutions of water. Many substances upon crystallizing from a solution, form molecular compounds containing water known as water of crystallization. The quantity of water taken up at a given temperature is always the same. In many instances the color of the salt is determined by the presence of this water of crystallization, as in copper sulfate, CuSCb.SIhO, which exhibits a blue color in the crystal- line form but becomes white upon the loss of its water of crystallization. Water of crystallization may usually be removed at from 100° O. to 105° C.; the substance then assumes its amorphous form. Water is composed of 2 parts of hydrogen and 1 part of oxygen. A mixture of these two gases, when ignited, explodes with violence to form water. By electrolysis water is resolved into these gases. The alkali metals and the alkaline-earth metals decompose water at ordinary temperatures while some of the other metals decompose it with the aid of heat. It combines with the oxides of some nonmetals to form acids. Water, as found in Nature, contains many inorganic and organic substances in solution. To obtain pure water these substances are removed by distillation. oxidation and eeduction.—When an element combines, with oxygen to form a compound it is said to be oxidized and the process or change which occurs is called oxidation. Compounds also may undergo oxidation when oxygen unites with one or more of the elements making up the compound. Oxidation usually is explained as being the addition of oxygen to an element or compound, the substance which furnishes the oxygen being termed the oxidizing agent, and the compound resulting from the combination with oxygen being called the product, an oxide of the element with which oxygen has combined. Examples of ordinary oxidation are: Substance Oxidizing agent Product 2Mg + O 2 —♦ 2MgO Cr203 + KCIO3 -* 2Cr03+KCl 696 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In a broad sense oxidation includes all chemical reactions, in many of which oxygen takes no part, which result in the addition of electro-negative elements or radicals to an element or compound, examples being: 2FeCl2+Cl2-+2FeCl3; and 4FeS04+2H2SOi-f 02 —>2Fe2 (SOi) s+2H20 When oxygen is partially or entirely removed from a compound it is said to be reduced and the process or change which occurs is called reduction, being usually explained as the removal of oxygen from a compound. The substance which unites with oxygen to remove it from the compound is termed the reducing agent and the substance resulting from the removal is called the product. Examples of ordinary reduction are; Substance Reducing agent Product KN03 + Pb -» KN02 + Pb0 Fe203 + H2 —> 2Fe0 + H20 Reduction also may he explained as the partial or entire removal of electro negative elements or radicals from a compound, examples being: 2FeCl3 + H2 -► 2FeCl2 + 2HCI Fe2(S04)3 + H2 2FeS04 + H2S04 Hydrogen and the metals form the electro-positive part of compounds; and oxygen, the nonmetals and most radicals the negative part. To facilitate the understanding of oxidation and reduction equations it is necessary to consider the valences of the substances involved from the viewpoint of the electronic theory. To determine the valence of each individual element in a ternary compound it is necessary to consider the hypothesis that the total sum of their respective valences is zero, i. e., the total positive electrical charges are exactly equal to the total negative electrical charges and the compound is neutral or has a valence of zero. In the compound H2SO4, hydrogen, each atom of which has a valence of plus 1 (H+), has a total valence of plus 2 (H+ +), and oxygen, each atom of which has a valence of minus 2 (0~ ~), has a total valence of minus 8(0 ). As but 2 of the 8 negative valences of oxygen have been satisfied or neutralized by the 2 positive valences of hydrogen, and as the compound H2SO4 is considered neutral or to have a valence of zero, the sulfur in this compound must therefore have valence of plus 6 (S+ + + + + +). It is also considered that an element in an uncombined state has a valence of zero and it should be remembered that this consideration is not to be confused with the true valence of elements as regards their chemical affinity. By applying this theory to the oxidation of sulfur, S+02 —> SO2, it is found that the valence of the sulfur changes from zero to plus 4, while at the same time each oxygen atom changes from zero to minus 2. When the positive valence of an element is increased, that element is said to be oxidized. As an example of this principle the oxidation of hydrochloric acid by manganese dioxide may be taken: Mn02+4HCl-*Cl2+MnCl2+2H20 Chlorine, when combined with hydrogen, has a valence of minus 1. Assuming the valence of chlorine is zero in an uncombined state, upon liberation it has become oxidized. In a similar fashion the valence of manganese in manganese dioxide, Mn02, which is the oxidizing agent, is plus 4, while in manganous chloride, MnCb, it is plus 2; during the reaction its valence has been reduced. Whenever an element loses positive valence it is said to be reduced. CHEMISTRY 697 This gives a broader conception of the terms “oxidation” and “reduction” and it will be found that this idea is a very convenient one to use. For example, in the oxidation of sulfur the valence of sulfur changes from zero to plus 4; therefore, it is oxidized; the valence of oxygen changes from zero to minus 2 so it is reduced. In the oxidation of hydrochloric acid the valence of chlorine changes from minus 1 to zero; hence, it is oxidized; the valence of manganese changes from plus 4 to plus 2, the element undergoing reduction. In the equations for these reactions both oxidation and reduction occur and in every case where one element undergoes oxidation some other element is reduced. In observing these two equations it will be noted that the gain and loss of valence are equal; one atom of sulfur gains 4 while each atom of oxygen loses 2. One atom of manganese loses 2 while each atom of chlorine gains 1. In every case of oxidation and reduction the total gain in valence is equal to the total loss. Balancing oxidation and reduction equations.—If the products of a reaction involving a change in valence are known, the coefficients required to balance an equation can be determined by the following rules: 1. Write the reactants and their products, as determined by the simple rules discussed under hydrogen, in the form of an unbalanced equation. 2. Select the elements which show a change of valence and indicate the valence of each atom above its symbol. 3. Determine the gain and loss, and what coefficients are required to make the gain and loss equal. 4. Use these coefficients in their proper places and complete the balancing. Usually it is best to leave hydrogen and oxygen until the last and if the quanti- ties of these elements check the equation is completely balanced. Hydrogen sulfide reacts with ferric chloride, reducing the iron to the fer- rous state with the liberation of sulfur and hydrochloric acid, the unbalanced equation being: FeCl3+H2S—>FeCl2+S+HCl. In changing valence each atom of iron loses 1 valence while each atom of sulfur gains 2; therefore, to balance the equation, there must be twice as many molecules of FeCU as there are of H>S. This leaves two atoms of hydrogen and two atoms of chlorine which unite to form 2 molecules of hydrochloric acid, and the balanced equation becomes: 2FeCl3+H,S-»2FeCl*+S+2HCI Another example is the reaction between potassium permanganate and hydro- chloric acid, in which free chlorine is liberated. Potassium permanganate being the oxidizing agent it appears probable that the resulting products will be free chlorine, water, and a chloride of each of the two metals, potassium and manganese. The unbalanced equation in this reaction will then be: KMn04+HCl-»KCI+MnCl2+H20+Cl The elements in this equation which show a change of valence are manganese and chlorine. In the compound KMnO-i manganese has a valence of positive 7 which, added to the valence of positive 1 of potassium, gives 8 positive valences to exactly balance the 8 negative valences of the 4 atoms of oxygen and make the compound neutral. As, in the compound MnCk manganese must have a valence of positive 2 to balance the valence of negative 2 of chlorine, it is evi- dent that manganese has lost 5 valences. In this reaction free chlorine is liberated as a gas. In this form chlorine can neutralize 2 positive valences and, although it is in an uncombined state, in order to work out the equation it is 698 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY considered as having a negative valence of 2, and therefore the chlorine liberated as a gas may be said to have gained 1 valence over what it had in the com- pound HC1. The valence of the chlorine in the chlorides of the metals remains unchanged and need not be considered. To balance this loss and gain of val- ences there must be 5 atoms of chlorine liberated for every molecule of KMnCh used, but as the free chlorine is expressed in its molecular form CL, to liberate 5CL (10 atoms of chlorine) it will therefore be necessary to use 2 molecules of KMn04. Using 2 molecules of KMnCh increases the number of atoms of oxygen in the oxidizing agent from 4 to 8 which have 16 negative valences that will require 16 positive hydrogen valences for balancing. Consequently 16 molecules of the compound HC1 are needed to react with 2 molecules of the compound KMnOi and the left side of the equation becomes 2KMnC>4+16HCl. By work- ing out this part of the equation so that the products previously mentioned are represented in the other part it will be found that the complete equation for the reaction is: 2KMn04+16HC1 —>.2KC1+2MnCl2+8H20+5C12 and examination shows that each side of the equation balances the other. It might be thought that in this reaction free oxygen would escape but it does not for as fast as it is liberated it is used in oxidizing hydrochloric acid to form water and chlorine. Oxidation and reduction may take place simultaneously in a reaction, an example being in the preparation of sulfuric acid from sulfur and nitric acid, when sulfur is oxidized by the oxygen in nitric acid and the nitrogen in nitric acid is reduced to nitric oxide. The unbalanced equation of this reaction is: S+HN03->H2S04+N0 In this equation sulfur, as an uneombined element, has a valence of zero while in the compound H2S04 it must have a positive valence of 6 as that is the number obtained by substracting the positive valence of 2 for hydrogen from the negative valence of 8 possessed by the 4 atoms of oxygen, and sulfur therefore has gained 6 valences. In the compound HN03 nitrogen must have a positive valence of 5 as that is the number obtained by subtracting the positive valence of 1 hydrogen from the negative valence of 6 possessed by the 3 atoms of oxygen, while in the compound NO it must have a positive valence of 2 to balance the negative valence of 2 of oxygen, and nitrogen therefore has lost 3 valences. Consequently, to balance the gain and loss of valences, there is required twice as much nitrogen as sulfur, and the balanced equation therefore is: S+2HNOs H.S04+2N0 It must always be remembered that oxidation and reduction bring about changes of valence and that oxidation leads to an increase and reduction to a decrease of positive valence. The Sulfur Family.—The elements usually considered as members of this family are sulfur, selenium and tellurium, between which there is such close family resemblance that only sulfur will be discussed with any detail. Ref- erence to the Periodic Table will show that with these elements in Group VI is the element oxygen from which it naturally would be expected that they all exhibit certain similarities in properties and might be considered as the oxygen family of elements. Certain properties of all are similar but others are in reverse order, and it is therefore customary to study oxygen singly and the others as the sulfur family. CHEMISTRY 699 sulfur.—Symbol: S; Atomic number: 16; Atomic weight: 32.06; Valence: II, IV, VI; Molecular formula: Ss, Sa, Sa, or S, depending upon temperature, Ss or S being used most commonly. Occurrence.—Sulfur is the “brimstone” of the Bible and is found uncombined in nearly all volcanic regions. Sicily and Louisiana are the chief commercial sources. In the combined state, sulfur is found in many mineral ores, especially as glcmce (mineral sulfides), and traces of it are found in the cells of animal and plant life. During the process of decay or disintegration this organically combined sulfur is liberated in the form of volatile compounds, especially hydrogen sulfide, which account for their permeating, offensive odor. Properties.—Sulfur is a pale yellow, tasteless and nearly odorless substance, insoluble in water. It may exist in several allotropic modifications depend- ing upon the temperature and physical forces to which it is subjected. These forms are crystalline, amorphous, and liquid. At ordinary temperatures sulfur is relatively inactive, but upon the application of heat it combines with nearly all the metals to form sulfides. Many nonmentals combine with sulfur, as chlorine, bromine, hydrogen, etc. Sulfur burns with a pale bluish flame and when heated with oxidizing reagents, it is converted into sulfuric acid. Caustic alkalies dissolve it to form a mixture of alkali sulfides and thiosulfate. Sulfur is used in large quantities for the preparation of sulfuric acid, sulfur dioxide for bleaching purposes, and vulcanized rubber. In medicine it is used externally and to some extent internally. Sulfur is obtained from its ores by melting, and from subterranean deposits by the application of hot water and air under pressure. Purification of the impure sulfur is carried out by sublimation. Hydrogen sulfide, H2S, is a heavy, colorless gas with a nauseating odor re- sembling that of rotten eggs. It is poisonous, and prolonged inhalation of its fumes will cause distressing symptoms and even death in dilutions as weak as 1 to 200. It is a powerful reducing agent and is extensively employed in chemical analysis to precipitate many metals from their salts as sulfides: PbO + H2S—>PbS J, +H20 This gas is extremely inflammable and burns with a pale blue flame. The products of its combustion are water and sulfur dioxide, or sulfur, if combus- tion is rapid. In aqueous solution it undergoes slow oxidation from contact with air, sulfur being precipitated. Boiled (air free) water should be used in preparing its solution, which is to be kept in well-closed containers away from light. It is decomposed by many oxidizing agents. Chlorine, bromine, and iodine combine readily with its hydrogen, precipitating sulfur: H2S+CI2—>2HC1+S I When solutions of metallic salts are treated with hydrogen sulfide various metallic sulfides of characteristic color and solubility are formed. These sulfides are divided into two large groups: 1. Sulfides insoluble in dilute acid (CuS, HgS, As2S3, etc.); 2. Sulfides insoluble in neutral or alkaline solutions, but soluble in dilute acids (NiS, MnS, ZnS, etc.). By application of these factors (solution or precipitation with an acid or base) and separation by filtration, the sulfides of most metals can be isolated, then identified, and their percentage estimated. This method is useful in detecting lead in the urine, and arsenic or mercury in the stomach, liver, and kidneys. 154294 °—39 45 700 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY Hydrogen sulfide is formed when a stream of hydrogen is passed over boiling sulfur. In the laboratory it is prepared by the action of hydrochloric acid upon a metallic sulfide in the presence of water: FeS+2HCl-»FeCl2+H2S f A generator similar to the one illustrated in figure 152 may be satisfactorily used. In the generator (A) is placed some ferrous sulfide covered with water and to it from time to time is added hydrochloric acid, sufficient to keep up evolution of the gas. The gas is readily evolved without the application of heat, and may be used directly or passed through a wash-bottle. Sulfur dioxide, SCh, is a colorless gas with a peculiar suffocating odor; it is easily liquefied at ordinary temperatures. It is a strong reducing agent, weakly acid in aqueous solution, and reacts with water to form sulfurous acid: SO2 H2O H2SO3 It also reacts with hydrogen sulfide, oxygen, and chlorine. Sulfur dioxide is the gas used in many mechanical refrigerators; sulfuric acid is manufactured from it, and it is employed as a bleaching and fumigating agent. It may be prepared by burning sulfur or metallic sulfides. Sulfuric acid, ELSCh, is an oily, colorless liquid with a density of 1.838 at 15° C. It mixes in all proportions with water, evolving much heat, and therefore should always be poured slowly into water to avoid spattering. Sulfuric acid is a powerful oxidizing and dehydrating agent, charring dry wood, sugar, and other organic substances. It combines with nearly all the metals to form sulfates; It is prepared on a commercial scale by two processes: 1. The Lead Chamber Process in which sulfur dioxide mixed with air is oxidized to sulfur trioxide (S03) by nitric acid vapors in a lead lined chamber, enough water being present to form sulfuric acid: Cu+ILSO.—»CuS04+H2 T 2S0a+2HN0s+H20-*2H2S(X+N0+N0: 2. The Contact Process in which sulfur dioxide mixed with air is passed over a catalyst, such as finely divided platinum or ferric oxide, at 400° C. and oxidized to sulfur trioxide. The sulfur trioxide is allowed to bubble through a mixture of sulfuric acid and water where it combines with the water to form more sulfuric acid: SOs+HaO—>H2SC)4 Sulfuric acid is used in the manufacture of nitro-glycerin, smokeless powder, hydrochloric acid from sodium chloride and nitric acid from sodium nitrate. selenium and tellurium, as well as their compounds, are very similar to sulfur and its compounds. Selenium is valuable chiefly because its electrical conductivity is greatly increased while exposed to light, making it useful in many automatic devices which are controlled by light; its molecular formula is Ses. Tub Niteogen Family.—This family consists of nitrogen, phosphorus, arsenic, antimony, and bismuth. These elements show a graded difference in their physical and chemical properties. The difference is more pronounced between these elements than those of the halogen group. In their chemical properties the nonmetallic properties gradually give way to the metallic with increase in atomic weight. CHEMISTRY 701 nitrogen.—Symbol: N; Atomic number: 7; Atomic weight: 14.008; Valence: III, V; Molecular formula: N*. Occurrence.—In the free state nitrogen constitutes about % of the atmosphere. It is found in large quantities combined with sodium and oxygen in Chili saltpetre. Combined with hydrogen in the form of ammonia, it is a by-product of the destructive distillation of coal. Animal and vegetable substances contain nitrogen which is given off as ammonia during the process of decomposition. Properties.—Nitrogen is a colorless, odorless, and tasteless gas. It is neither combustible nor capable of supporting combustion. In the free state it is inactive, but nearly all nitrogen compounds are very active, the alkaloids and cyanides being quite toxic to animal tissues. The preparation of its compounds is almost always performed by indirect means. Isolation.—Nitrogen may be prepared by removing the oxygen from the air, or by chemical means through the reaction of potassium dichromate on ammonium chloride: K2Cr20r+2NH4CI-*Cr203+2KCl+4H20+N2 Ammonia, NIL, is a colorless gas with a pungent suffocating odor and caustic taste, quite soluble in water. It is alkaline to litmus and combines with acids to form ammonium salts. The formula NIL (ammonium) represents a hypo- thetical compound that has many properties in common with potassium and sodium. Ammonia gas, NIL, combines with water to form a weak hydroxide, NELOH, the equation being: NEL-f-ELO—>NELOH. Ammonia is used chiefly in mechanical refrigeration and in the production of nitric acid. In dilute aqueous solutions it is an effective cleaning fluid. Nitrous oxide, N20, is a colorless gas with a faint peculiar odor and sweetish taste. It supports the combustion of many substances almost as actively as oxygen. A mixture of nitrous oxide and hydrogen explodes with violence when ignited. This gas is used extensively in minor surgery and dentistry when a short anaesthesia is desired. The anaesthetic effect is controlled by inhalation of the gas mixed with oxygen. Aside from its anaesthetic effect, it is physio- logically inert. The usual method of preparation is by heating ammonium nitrate at a temperature of below 250° C., decomposing it into nitrous oxide and water: NH4N0s+Heat-»N20+2H20 Nitric oxide, NO, is a colorless gas which produces reddish colored fumes upon contact with the oxygen in the air, forming nitrogen dioxide; 2NO+02—>2NOa Nitric oxide will not burn, but supports combustion at high temperatures. It is used in the manufacture of nitric acid, and sulfuric acid by the Lead Chamber Process. Nitric acid (aqua fortis), HNOa, is not found in Nature in the free state, but the nitrate radical (NOs) in nitric acid, is found combined with potas- sium, sodium, calcium, and magnesium in the nitrates of those elements, the largest known deposits of nitrates being the sodium nitrate beds of the rain- less districts on the coast of Chile. Nitric acid is a colorless, fum/ing, very corrosive liquid. When exposed to light it assumes a yellow to orange color due to slight decomposition, with the formation of nitrogen dioxide (NCh). Due to its unstable character nitric acid acts as a powerful oxidizing agent. Through action that occurs within itself nitric acid frequently is reduced, forming the lower nitrogen oxides NO, N2O3, and N02. As a result of such energetic properties, it dissolves nearly all the metals, with the exception of 702 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY gold and platinum, forming nitrates, or converting them into acids and in- soluble oxides according to their nature: Due to the oxidizing action of nitric acid upon hydrochloric acid, chlorine is liberated in its most active (nascent) form. This atomic chlorine reacts vigorously with metals and is useful in combining with those metals which are below hydrogen in the Electrochemical Series, especially gold and plat- inum. Such a mixture, containing 1 part of nitric acid to 3 parts of hydrochloric acid, is known as nitrohydrochloric acid (aqua regia). Many organic substances, such as turpentine, burst into flame upon contact with nitric acid, while others merely turn yellow. Substances like cotton, benzene and glycerin undergo a process of nitration when treated with the concentrated acid (nitro-cellulose, nitro-benzene, nitro-glycerin). In dealing with nitric acid it must be clearly remembered that it has two actions, that of an acid and that of an oxidizing agent. Nitric acid containing nitrogen tetroxide, which imparts an orange color to the liquid, is known as fuming nitric acid. This substance is prepared by the addition of paraformaldehyde or a little starch to the colorless acid and heating the solution. This form of nitric acid is more energetic in its oxidizing power than the colorless variety. Nitric acid has extensive commercial applications, being employed in the manufacture of sulfuric acid, explosives, artificial silks, and many other important commodities. It is used as a solvent in the refining of precious metals. Nitric acid is produced from sodium and potassium nitrate by heating them in a retort with sulfuric acid; 3Hg+8HNOs-»3Hg (N03) 2+4H20+2N0 The nitric acid distills over, is concentrated, and then purified. Nitrates are monobasic salts prepared by dissolving a metal or its oxide in nitric acid. Nearly all the nitrates are soluble in water with the exception of a few basic salts. The alkali nitrates are employed in dry oxidation. phosphorus.—Symbol: P ; Atomic number: 15; Atomic weight; 31.02; Valence: III, V; Molecular formula : P4. Occurrence.—Phosphorus is never found in the free state, but chiefly as tri-calcium phosphate, which is the principal constituent of bones as well as of the minerals, apatite, CaFs.SCasCPChh and phosphorite, CastPChh. Both of these minerals are used extensively in commercial fertilizers. Phosphorus is also found distributed in comparatively small quantities in plant and animal tissues, in the soil and in sea-water. Properties.—Phosphorus exists in several allotropic forms, yellow and red phosphorus being the most important. The yellow variety is a translucent, wax-like solid which is soft enough to be cut with a knife at ordinary tem- peratures. It is insoluble in water but extremely soluble in carbon disulfide, 1 Gm. dissolving in 0.9 cc. In handling, phosphorus must be kept under water because it is a very inflammable substance, igniting spontaneously in the air at 40° C. The phosphorescence visible in the dark upon exposure to air, appears to be due to slow oxidation. Yellow phosphorus possesses a great affinity toward many elements, uniting directly with nearly all except nitrogen, the inert gases, carbon and the noble metals. With bromine and sulfur it reacts violently. Due to its great affinity for oxygen it is a powerful reducing agent. It decomposes nitric acid with H2S04+2NaN0s->Na3S04+2HN0s. CHEMISTRY 703 explosive violence, and reduces salts of some metals, as mercury, gold and copper, to metals and phosphides. Red, or amorphous phosphorus, an allotropic form, possesses essentially different properties from the yellow variety, being a dark red to yellowish brown, inodorous powder which is insoluble in carbon disulfide and all other solvents. It does not phosphoresce and is stable in air. Red phosphorus is prepared by heating the yellow variety to 300° C. in airtight chambers. After the conversion, the resulting product is treated with carbon disulfide to remove any remnants of yellow phosphorus. The chief use of this variety is in the manufacture of safety matches. It is also extensively employed in organic synthesis. The red variety is not poisonous, whereas the yellow variety produces burn- ing in the stomach, vomiting and convulsions. The inhalation of the vapors, for any length of time, causes necrosis of the bones and liver. Isolation.—Phosphorus is obtained from bone ash by treatment with silica and coke in the “continuous acting” electric furnace process: 2Ca3(PO4)2+6SiO2+10C-»P4+6CaSiO3+10CO T Phosphorus combines readily with the halogens to form compounds of the types Pi?3 and PR-,, R representing any of these elements. Four oxides and eight acids of phosphorus are known: are known : Oxides Acids Phosphorus protoxide P20 Hypophosphorous acid _ Phosphorus trioxide PiOfl Orthophosphorus acid __ .. Phosphorus tetroxide P2O4 Metaphosphorous acid... HPO2 Phosphorus pentoxide P2O5 Orthophosphoric acid Metaphosphoric acid Pyrophosphorous acid Pyrophosphoric acid Hypophosphoric acid HPO? —H4P2O5 H4P2O8 The meta- and pyro-phosphoric acids are anhydrides of orthophosphoric acid and may be considered derivatives of phosphoric oxide plus varying amounts of water: P2O5+H2O—>2HP03 P2O5+2H2O—>H4P207 P205+3H20->2HsP04 Phosphorus Pentoxide, Pa0B, is a bulky, white, amorphous, or crystalline powder, prepared by burning phosphorus in iron cylinders supplied with a cur- rent of dry air and purified by subsequent sublimation in a current of oxygen to free it from ous oxides. Phosphorus pentoxide has a powerful affinity for water, producing a hissing sound when thrown into it. Because of this property it is used as a desiccating agent, especially for drying gases. Orthophosphoric acid (anhydrous), H3PO4, occurs in rhombic prisms which, on exposure to moist air or upon addition to water, deliquesce to a thick syrupy liquid. The Acid Phosphoricum, U. S. P., contains not less than 85 per cent, nor more than 88 per cent of HsPCh. When heated from 200° C. to 215° 0., orthophosphoric acid is gradually con- verted into pyrophosphoric acid H4P2O7. When heated above 400° C. it is com- pletely converted into metaphosphoric acid, HPOa. 704 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY This acid forms 3 classes of salts depending upon the number of hydrogen atoms replaced by a metal: Primary phosphate NaHaPCh Secondary phosphate Na2HPOi Tertiary phosphate NasPCh Arsenic.—Symbol: As; Atomic number : 33; Atomic weight: 74.91; Valence: III, V; Molecular formula : As4. Occurrence.—Arsenic is widely distributed in nature. In the free state it is usually found in crystals, while in the combined state it is abundantly distrib- uted as sulfides or metallic arsenides. Small quantities of arsenic are found in many mineral waters and in sea-water. Properties.—Arsenic usually occurs in the form of a steel-gray, brittle, crystal- line mass. It exhibits two allotropic modifications, crystalline and amorphous. The latter form is black and when heated to 360° C. reverts to the crystalline form. Isolation.—Arsenic is obtained by heating arsenical pyrites out of contact with air. The arsenic sublimes, leaving the iron as a sulfide. Arsenic forms compounds analogous to those of nitrogen and phosphorus, arsenic trioxide being one of the most important. Arsenic trioxide, or arsenious oxide, AS2O3, is a white amorphous or crystalline powder having three allotropic forms, each variety depending upon its crystal formation. It is readily oxidized to arsenic oxide, hence, it is employed as a reducing agent. With the alkali hydroxides it readily forms salts. Arsenic trioxide is a powerful irritant poison, the antidote being the Magma Ferri Hydroxidi of the U. S. P. which acts as a colloid, absorbing the arsenic and rendering it innocuous. In small doses arsenic trioxide and other arsenical compounds are widely employed in medicine. It is also used in the preparation of dyes. Antimony.—Symbol: Sb; Atomic number: 51; Atomic weight: 121.76; Valence: III, V. Occurrence.—The chief source of antimony is the antimony glance or stibnite, Sb2S3. Native antimony is usually accompanied by arsenic. Properties.—Antimony is a silver-white, lustrous metal, more basic than arsenic, but less so than bismuth. It possesses both metallic and nonmetallic properties, combining with oxygen and the halogens. Strong nitric acid and sulfuric acid react with it to form the nitrate and sulfate, but with dilute acids no reaction occurs. In combination with other metals it composes some of the more common alloys. Aside from the fact that some of its compounds, which are similar to those of arsenic, are used in medicine, they have very little practical value. bismuth.—Symbol: Bi; Atomic number; 83; Atomic weight: 209.00; Valence: III, V. Occurrence.—The commercial sources of bismuth are not numerous. Both the metal and its ores are generally disseminated through rock. Bolivia is now the chief source of supply. Properties.—Bismuth is a hard, brittle, lustrous, white metal of crystalline structure, being isomorphous with arsenic and antimony. It is chemically inactive at ordinary temperatures, but at elevated temperatures it is converted into the oxide: 4FeAsS+Heat—>As4+4FeS 4Bi+302—>2BiaOa CHEMISTRY 705 It is acted upon by hot nitric and sulfuric acids. Combination with the halogens takes place slowly. The insoluble salts are employed in medicine, while metallic bismuth is a valuable constituent of various alloys. Both bismuth and arsenic are extensively used as spirochseticidal agents in the treatment of syphilis. Carbon and Silicon.'—These are the first two elements in Group IV of the Periodic Table and are the only ones of the two families in this group that will be here discussed. Carbon is the essential element in the organic world and it has far more compounds than any other element due to the fact that its atoms possess the power of combining with each other and thus forming compounds that are very complex in character. The organic compounds of carbon possess certain well-defined characteristics, thousands of them are known, and many can be prepared by synthesis from the elements. So numerous are the compounds of carbon that most of them are considered and studied as a special branch of the science of chemistry known as organic chemistry, which later will be briefly discussed. Silicon occupies in the mineral or inorganic world the same position that carbon does in the organic, and is considered as the most important element in that world. carbon.—Symbol: C: Atomic number: G; Atomic weight: 12.01; Valence: IV. Occurrence.—Carbon occurs in Nature in three allotropic forms, two of which are crystalline and the third amorphous. The two crystalline forms are the diamond and graphite. Amorphous carbon occurs naturally in the various forms of coal and many amorphous forms may be prepared, as coke, charcoal, boneblack, lampblack, and soot. Combined with hydrogen and other elements it comprises all organic material and their by-products. Carbon and its com- pounds are found widely distributed in the Earth as coal and oil. Properties.—Carbon is an odorless, tasteless, black solid except in the diamond where it is colorless. Different forms vary in hardness and electrical con- ductivity, intense heat converting them all to the graphite modification. It has great absorbing powers which are employed in the refining of sugar and the construction of gas masks. Carbon when heated unites readily with oxygen, hydrogen and some of the metals. As coke it is a reducing agent used in blast furnaces. It is an amphoteric element exhibiting both metallic and nonmetallic properties. Car- bon stands alone among the elements in that it is capable of combining with itself to form long chains of carbon atoms. Silicon possesses this property to some degree but the length of the chain is limited. Carlon dioxide, CO2 is a colorless, odorless, heavy gas, soluble in an equal volume of water at 15° C. but much more so under pressure. It is a product of the oxidation of all organic matter, being formed in both combustion and decay, and of many fermentation processes, and is exhaled from the lungs of all animals in respiration. It will not support combustion nor is it com- bustible. Metallic oxides unite with it to form carbonates: Carbon dioxide reacts with water to form the hypothetical carbonic acid (H2O+CC; which has never been isolated because upon liberation it immediately reverts to carbon dioxide and water. In solution, it reacts with bases to produce carbonates, or bicarbonates if an excess of acid is present. Carbon dioxide is used in fire extinguishers, leavening agents, and in the manufacture of carbonated beverages. CaO-j-CO*—>CaC03 706 HANDBOOK OP THE HOSPITAL CORPS, U. S. NAVY Carbon monoxide, CO, is a colorless, poisonous, almost odorless gas formed from the incomplete combustion of carbon, 2C+02—>2CO. It escapes from stoves too closely damped, kerosene heaters, automobile exhausts, and is a constituent of illuminating gas. Dilutions of 1 in 800 are fatal if breathed for one-half hour. It is a good reducing agent, extracting oxygen from hot metallic oxides. Phosgene, COCh, is a gas used in chemical warfare. Carbon tetrachloride, CC14, is valuable as a solvent and fire extinguisher. Carbon disulfide, CS2, is a highly inflammable liquid and is of value as a solvent of rubber, sulfur and other substances. It is also an efficient exterm- inator of vermin. Cyanogen, C2N2, is a very poisonous gas from which is derived hydrocyanic acid, HCN (“prussic acid”), a colorless, extremely poisonous, volatile liquid characterized by its almond-like odor. Hydrocyanic acid reacts with most of the metals to form cyanides and cyanates. It is used in the fumigation of ships. silicon.—Symbol: Si; Atomic number : 14 ; Atomic weight: 28.06; Valence: IV. Occurrence.—Silicon does not occur in the free state, is not found in the air either as an element or a compound, and is not present to any consider- able extent in water. Except for oxygen, it is the commonest element, com- posing one-fourth of the Earth’s crust. It is found in quartz, sand, and sandstone. Clay and all common rocks, except limestone and dolomite, are silicates. Properties.—Silicon occurs in two allotropic forms, amorphous silicon which is a brown powder, and crystalline silicon which is obtained as hard, black, hexagonal crystals. It burns in oxygen and combines with the halogens at suitable temperatures to form gases. It is insoluble in acids, but dissolves readily in sodium hydroxide, displacing hydrogen from the solution: Silicon is capable of uniting with itself in a manner similar to that of the carbon atoms, but whereas the carbon atom is capable of building an almost limitless number of complex molecules, the limit of stability for the silicon chain is SioHu. It is of importance in the manufacture of glass. The element is isolated by reducing the oxide with powdered magnesium or aluminum: 4NaOH+Si—>Na4SiO*+2H2 Si02+2Mg—»2MgO+Si, or 3Si02+4AI-»3Si+2Al203 The metals. The Alkali Metals.—The elements of the alkali group constitute a family in Group I of the Periodic Table and have a valence of I. They are called alkali metals because the most familiar members of the family, sodium and potassium, are found in compounds that have long been known as alkalis. The members of this family possess certain properties in common in that they are light, soft metals with a low melting point, silvery-white in appear- ance, and of a bright metallic luster when pure. They oxidize in air and energetically decompose water, with the evolution of hydrogen, to form hydrox- ides of a strong alkaline reaction. They occupy places near the top of the electrochemical series which shows they are very active metals, do not occur free in Nature, and their compounds with very few exceptions, are white solids soluble in water. Sodium and potassium are the most important members of the family. CHEMISTRY 707 sodium.—Symbol: Na ; Atomic number: 11; Atomic weight: 22.997; Valence: I. Occurrence.—Sodium, like all other alkali metals, is not found in Nature in the free state but in combination with other elements in which form it is widely distributed throughout the world. Combined with chlorine it forms the salt of sea-water and rock-salt mines. Properties.—Sodium is a silvery-white metal of waxy consistency at ordinary temperatures prepared in various ways. It decomposes water, reacts with acids forming the corresponding salts and liberating hydrogen, and combines directly with the halogens: and has a great affinity for oxygen : 2Na+Cl2—>2NaCl 2Na+0_. —♦ N a20. It is a good reducing agent, displacing hydrogen from water and alcohol: 2Na+2H20—»2NaOH+H2 When heated in the Bunsen flame it, as well as most of its compounds, volatil- izes and colors the flame yellow. Sodium and its compounds are of great importance. Isolation.—Sodium is isolated by the electrolysis of fused sodium hydroxide in Castner cells. Sodium chloride, NaCl, is found in rock-salt deposits, salt lakes, and sea- water. It occurs as transparent cubical crystals and as a white crystalline powder. When calcium or magnesium is present it is more or less hygroscopic, but in the pure state it does not possess this property. It is used in the prepa- ration of other sodium compounds and reacts with nonvolatile acids to form hydrochloric acid: NaCl+H2S04 NaHS04+HC1 It is the principal condiment used for seasoning food and also acts as a food preservative. Mined in the comparatively pure state it is sent into commerce without further purification. Large quantities are obtained from the evapora- tion of sea-water. Sodium hydroxide, NaOH, is a white, solid, hard mass that is deliquescent in the presence of moist air. It is extremely basic to indicators and is a strong caustic. It has many uses, being employed in large quantities in the manufacture of soap and in the neutralization of acids to form their sodium salts. It may be prepared by the electrolysis of sodium chloride. Sodium bicarbonate, NaHCOs, is a white opaque powder, permanent in air under ordinary circumstances but decomposing slowly in moist air. It has a mild alkaline reaction which increases upon long standing due to the loss of carbon dioxide and subsequent formation of sodium carbonate. It is the main constituent of most baking powders and has considerable use in the textile industry. In medicine it is used as an antacid. Nearly all the sodium bicar- bonate of commerce is prepared by the Solvay Process which is known as the ammonia-soda process, the reaction being: Sodium carbonate, Na2COs, closely resembles sodium bicarbonate except that its alkaline reaction is stronger due to its greater hydrolysis in water. It is prepared by heating sodium bicarbonate: NaCl+NH3+C02+H20^NaHC03+NH4Cl 2NaHCa+Heat-»Na!!C03+C02+Ha0 708 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY potassium, lithium, eubidium, and cusiuM are similar to sodium in their properties. The Alkaline Earth Metals.—The metals of this group are grayish-white in color, of a bright metallic luster, malleable and ductile. They belong to Group II of the Periodic Table, have a valence of II, are very active, tarnish quickly in air, and react with water to form hydroxides, with hydrogen being liberated. The halogens and nitrogen combine with them directly. The hydroxides of these metals increase in solubility with the increase in atomic weight of the metals; the sulfates decrease in solubility with the increase in atomic weight. magnesium.—Symbol; Mg; Atomic number: 12; Atomic weight: 24.32; Valence: II. Occurrence.—This element is not found in the uncombined state in Nature, however, its compounds are widely distributed. Properties.—'Magnesium is a silvery-white, highly lustrous metal. It is stable in dry air but in the presence of moisture gradually becomes covered with a film of magnesium oxide. Heated in air it ignites and burns with a blinding white light which is especially rich in actinic rays. It is employed in photog- raphy as a flashlight powder, and in the manufacture of fireworks and light- weight alloys. It decomposes slightly at 100° C. or over in air with the formation of magnesium oxide (MgO) and some magnesium nitride (Mg3N2). Isolation.—Magnesium is isolated by the electrolysis of the fused double chloride, MgCl2.KCl.6H2O (carnallite). Magnesium chloride, MgCl2, is found in sea water and certain salt deposits. It is very deliquescent in air. Magnesium sulfate, MgSCb, is found along with the chloride in salt deposits; the hydrate, MgS04.7H20, is known as Epsom Salts. calcium.—Symbol: Ca; Atomic number: 20; Atomic weight: 40.08; Va- lence: II. Occurrence.—The compounds of calcium are widely distributed in Nature, the carbonate being the most abundant. Properties.—Calcium is a tough and malleable silvery-white metal with a bright luster. It resists oxidation in dry air, but in the presence of moisture it quickly becomes covered with the hydroxide which gradually extends throughout the whole mass. It is very active chemically and at high tempera- tures burns with a brilliant white light. Isolation.—Calcium is isolated by the electrolysis of the fused chloride. Calcium carbonate, CaC03, is found as limestone, marble, and chalk. It is a white transparent solid insoluble in water, but dissolved by most acids with the liberation of CO2. It is used in the building industries as stone, mortar, plaster, etc. Calcium oxide, CaO, (lime) is prepared by heating calcium carbonate: CaCOs+Heat—>Ca0+C02 It is a white solid which reacts with water, forming calcium, hydroxide and producing considerable heat: CaO+H.O—>Ca (OH) 2 beryllium, strontium, and barium are elements somewhat similar in their properties to magnesium and calcium. Boron and Aluminum.—Boron and aluminum are the first two elements of Group III in the Periodic Table. None of the other elements in this group are abundant or well known. Boron is a nonmetal; aluminum is a metal. A valence of III is shown by both elements in all their compounds. CHEMISTRY 709 Boron more closely resembles silicon than aluminum in its properties. boron.—Symbol: B; Atomic number; 5; Atomic weight: 10.82; Valence: III. Occurrence.—Boron does not occur in the free state but is found combined with oxygen and hydrogen as boric acid and sodium borate, or borax, deposits of the latter being located in California and Nevada in the United States and in Peru and Chile, South America. Properties.—Boron is an amorphous powder which can be fused to a very hard and brittle mass. It combines slowly with oxygen at 100° C. and at high temperatures bums with a green flame: The halogens combine with it at high temperatures; nitric acid oxidizes it to boric acid, and the metals combine with it to form borides. There are no important uses of boron. Isolationj—Boron is Isolated by heating boric trioxide with magnesium to redness. The resultant mass is treated with hydrochloric acid and alkalies. Boric acid, H3BO3, occurs in certain volcanic districts, especially in Tuscany where it is obtained by condensing the vapors of hot springs. It may be pre- pared by treating borax (Na2B4Or.l0H2O) with an acid. It is sparingly soluble in water and has weak acidic properties. Its main use is as a mild antiseptic. aluminum.—Symbol: A1; Atomic number : 13; Atomic weight: 26.97; Valence; III. Occurrence.—Aluminum composes 7 per cent of the Earth’s crust, being the most abundant metal. Due to its chemical activity it is never found in the free state. Properties.—It is a bluish-white metal of high luster, somewhat malleable and ductile. Water does not act upon it at any temperature. It combines with many of the nonmetals, especially the halogens, and with members of the sulfur family. It reacts with acids: •lB+302—»2B20s and soluble bases 2A1+6HC1—> 2 A1C13+3H3, 2Al-j-6NaOH—^NasAlOs+SHa In oxygen it burns with a brilliant light and is used in the manufacture of flashlight bulbs. Most cooking utensils are now made of aluminum. Light- weight alloys are also largely aluminum. Isolation.—Aluminum is isolated by the electrolysis of bauxite, molten cryolite being used as the solvent. Aluminum oxide, AhOs, is found in Nature as corundum, and in the finer crystals as ruby and sapphire, colored red or blue, due to traces of metallic oxides. Rare Earths.—These elements are trivalent and when oxidized are of the general formula Rf)s. The hydroxides are white amorphous precipitates which do not dissolve in alkali hydroxides. With alkali sulfates they form double salts. Copper.—Symbol: Cu; Atomic number: 29; Atomic weight, 63.57; Valence: I, II. Occurrence.—Metallic copper is found in the free state and in combination with other elements. It is obtained from its ores by smelting. Properties.—Copper is a lustrous, malleable, and ductile metal with a peculiar reddish color. Next to silver it is the best conductor of electric current and its most important use is as “electric wire”. It forms two series of com- pounds, those in which the valence is I (cuprows), and those in which the valence is II (cupric). 710 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Copper sulfate, CuSCh, is prepared by the action of sulfuric acid on copper. The crystalline form has a bluish color. When the crystals are heated they lose their color and become a white, amorphous powder which reverts to the blue crystalline form upon the readdition of water. It is used in copper refining, electroplating and calico printing. It is occasionally used in lakes and reservoirs to kill organisms such as algae. Zinc.—Symbol: Zn; Atomic number: 30; Atomic weight: 65.38; Valence: II. Occurrence.—Zinc occurs chiefly as a sulfide or zinc blende, and as a car- bonate. The pure metal is obtained by roasting and refining. Properties.—Zinc is a bluish-white metal, malleable and ductile between 100° C. and 150° C. and is used in the manufacture of galvanized iron, bronze, brass,' German silver, and other alloys. Zinc tarnishes readily but the forma- tion of a basic carbonate prevents its oxidation. In a flame it burns with a blue color. Acids act upon it to form salts. Soluble bases combine with it to form zincates: Zn+2HCl->ZnCl2+H2; Zn+2Na0H-^Na2Zn02+H2 Zinc oxide, ZnO, is made by burning zinc vapors in oxygen. It is a white powder used in paints. Zinc sulfate, ZnSQt, is used in printing, dyeing cloth, and in medicine as an astringent. All zinc compounds are poisonous. Mercury.—Symbol: Hg; Atomic number; 80; Atomic weight: 200.61; Valence; I, II. Occurrence.—Mercury is found in the native state as minute globules dis- seminated throughout its ores. The most abundant mercury ore is cinnabar, (mercuric sulfide, HgS). Properties.—At ordinary temperatures mercury is a liquid, silvery-white, lustrous metal. When cooled to minus 38.8° C. it forms a malleable, ductile, and crystalline solid. It is insoluble in water or other solvents. At ordinary temperatures hydrochloric and sulfuric acids have no effect upon it, but when boiled with the latter it slowly dissolves with the evolution of sulfur dioxide. Nitric acid dissolves it rapidly, forming mercurous nitrate if the mercury is in excess, and mercuric nitrate if the nitric acid is in excess: 6Hg+8HN03-»6HgN08+2N0+4H20; 3Hg+8HN03->3Hg(N0a)2+2N0+4H20 With oxygen it combines to form an oxide; this action is reversible: 2Hg+G2^2HgO The halogens combine with mercury at ordinary temperatures. Many metals, such as gold and silver, form an amalgam with mercury. Mercuric chloride, HgCh, is a white crystalline salt, soluble in water, made by heating a mixture of mercuric sulfate and sodium chloride. It is a power- ful antiseptic and a dangerous irritant poison. Mercurous chloride, HgCl, is a white powder prepared by heating mercuric chloride with mercury. It has extensive use in medicine. The Tin Group.—Germanium, tin, and lead, along with carbon and silicon form a group in which the elements exhibit a valence of II and IY. A sub- group related to these are titanium, zirconium, and thorium. tin.—Symbol: Sn; Atomic number: 50; Atomic weight: 118.70; Valence: II, IV. CHEMISTRY 711 Occurrence.—The most important tin ore is cassiterite, or tin stone, Sn02, found most abundantly in the Malay States, Bolivia, the East Indies, and China. Propertiesf.—Tin is a white, lustrous metal existing in two allotropic forms, the gray form being brittle and easily crumbled into powder, while the white variety is soft and malleable. It is not affected by air or water at ordinary temperatures, but when strongly heated in a flame it burns with an intense white light to its oxide, SnCh. Tin reacts with the strong acids and hot con- centrated solutions of the strong alkalies, but is not affected by organic acids and weak alkalies. Due to its resistance to many chemical solutions it is used to plate copper and iron vessels. Most of it is used for tin plating cans, and it is a constituent of alloys such as bronze. Isolation.—Tin is obtained by reducing the oxide, Sn02, with carbon in a reverberatory furnace. Many of the compounds of tin are used in the dyeing industry. lead—Symbol: Pb ; Atomic number: 82; Atomic weight: 207.21; Valence: II, IV. Occurrence.—The most important and abundant source of lead is the sulfide (galena), PbS, which is widely distributed. Properties.—Lead is a silvery-grayish metal, soft and malleable, easily cut with a knife, and when drawn across paper it leaves a gray streak. In the presence of air a coating of lead oxide is formed which protects the metal from further oxidation. Cold concentrated hydrochloric and sulfuric acids have but little action on it. When boiled with these acids the chloride and sulfate are formed. With nitric acid it acts readily to form lead nitrate and oxides of nitrogen: 3Pb+SHNOs -*3Pb (NOa) 2+4H20+2NO Large quantities of lead are used in the plumbing industry and in the manu- facture of storage batteries, alloys and paints. Isolation.—Lead is obtained from its ores by roasting in a current of air to oxidize the sulfide: 2Pb S+30a —>2Pb0+2 S02 The air supply is removed after % of the ore has been oxidized and then the temperature is raised. This produces metallic lead: PbS+2PbO-»SPb+SOa Oxides of lead.—Litharge (PbO), red lead (PbsCh), and lead dioxide (PbCb) are the important oxides of lead. The first is used in glass manufacture, the second as a paint pigment, and the third in making storage batteries. Basic lead carbonate, 2PbC03.Pb(0H)2 (white lead) is prepared by the action of air, carbon dioxide, and acetic acid upon perforated lead plates. It is used as a paint pigment. The Iron Group.—This group, No. VIII in the Periodic Table, contains iron, nickel, and cobalt. It is distinguished because of the magnetic properties of its members. Iron.—Symbol: Fe; Atomic number: 26; Atomic weight: 55.84; Valence: II, III. Occurrence.—Iron occurs free in meteorites, and combined as oxides, car- bonates, silicates and sulfides. Properties.—Pure iron is of a silvery-white appearance. In this state it is too soft for commercial purposes, therefore, small quantities of other elements, such as carbon, silicon and manganese are added to give it hardness. When 712 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY iron is combined with small quantities of carbon it is known as steel. Dry air, or water free from carbon dioxide, does not affect iron, while the presence of moisture and carbon dioxide causes the formation of hydrated ferric oxide (rust). Concentrated nitric acid and sulfuric acid have no action hpon iron at ordinary temperatures, although when diluted they attack it readily. Isolation.—Iron, as used in commerce, is obtained by reducing its ores in blast furnaces. Pure iron is isolated by electrolysis or reduction of the pure oxide in a current of hydrogen. Ferric chloride, FeCL is prepared by burning iron wire in chlorine. It is extremely soluble in water and alcohol. Its alcoholic solution is known as Tincture of Ferric Chloride. Ferrous chloride, FeGU, is prepared by treating iron with hydrochloric acid, in the absence of air: Silver and Gold.—Silver and gold are known as the noble metals and appear in Group I In the Periodic Table. This group also includes copper to make a family of three members, although there is not much resemblance in the chemistry of any two of these elements. Copper and gold usually have a higher valence than I which is characteristic of this group. silver.—Symbol: Ag; Atomic number: 47; Atomic weight: 107.88; Valence: I. Occurrence.—Silver is found free embedded in rock, or in combination as argentite (Ag2S) and as silver chloride (horn silver). Properties.—Silver is a soft, white, lustrous metal capable of taking a high polish. It is very malleable and ductile, and the best conductor of electrical current. Air and water have no action upon it. Nitric acid attacks it readily with the formation of silver nitrate: Fe+2HCl-*FeCl2+H2 GAg+8HNO3 —>6AgN03+4H20+2NO Hydrochloric and dilute sulfuric acids have but slight action upon silver even at boiling temperatures, while hot concentrated sulfuric acid dissolves it form- ing silver sulfate and liberating sulfur dioxide. It reacts readily with the halogens. The alkalies have little or no action upon it. Isolation.—In the combined state silver is obtained from its ores by smelt- ing. It is removed from rock, where it occurs in the free state by crushing the rock and amalgamating the silver with mercury, after which the mercury is removed by distillation. Some of the silver salts are used in photography and medicine. Silver nitrate, AgNOa, is prepared by the action of nitric acid upon pure silver. This compound is used in the manufacture of other silver compounds and indelible inks. In medicine it Is used as a caustic. In ancient times silver and gold were among the few metals known. Gold was symbolical of the sun and silver of the moon (luna), hence the term “lunar caustic” applied to this compound. gold.—Symbol: Au ; Atomic number : 79; Atomic weight; 197.2; Valence; I, III. Occurrence.—Gold is ordinarily found in the free state, widely distributed but in small quantities. Properties.—Gold is a soft, heavy, bright yellow metal, extremely malleable and ductile. It is very inactive and will not react wuth any of the common acids; it dissolves in nitrohydrochloric acid (aqua regia) however, and in sodi- um cyanide with the presence of oxygen. The fused alkalies corrode it. This metal has been basis of currency throughout the world for centuries. Large quantities are used for making jewelry, and in dentistry. CHEMISTRY 713 ORGANIC CHEMISTRY Introduction. By the middle of the seventeenth century the study of the substances occur- ring in Nature had so far developed that they were grouped in the three natural kingdoms of animal, vegetable, and mineral matter. At this time the study of chemistry was divided into three branches, each dealing with the substances in one of these kingdoms, and chemists devoted themselves mainly to the study of mineral or nonliving substances. Following the discovery that certain substances are formed in the growth of both animals and plants the distinction between animal and vegetable chem- istry was discarded and substances produced by organized life-processes became known as organic. It was then believed that such substances were formed as the result of the so-called “vital force” in living things and could not be artificially produced by chemists. Although Lavoisier showed that organic substances are composed largely of carbon, hydrogen, oxygen, and nitrogen, and it was known that inorganic substances could be artificially prepared in chemical laboratories, the belief that organic substances could be produced only within living organisms persisted for many years. In 1828 Friedrich Wohler, a German chemist, in the course of some experi- ments, discovered, much to his surprise, that by warming ammonium cyanate it was transformed into urea, a waste product of the body that is secreted into the urine by the kidneys. Urea is a typical organic compound and pre- viously had been known only as a product of living organisms, while am- monium cyanate was essentially a laboratory-prepared compound. With Woh- ler’s production of a typical compound normally produced by the living organism from inert or nonliving matter the belief that “vital force” was necessary for the formation of organic compounds began to disappear, and by the middle of the nineteenth century had been abandoned, but the term organic chemistry survived and is used today to define this branch of chemistry, principally to distinguish it from inorganic chemistry. Since the first synthesis of an organic compound investigations have shown that organic substances obey the same laws of composition as inorganic sub- stances and enough syntheses of substances occurring in the living organism have been made to show that the chemical changes that take place in the living organism obey the same laws as those that occur in the laboratory. It has been further shown that carbon is present in all so-called organic compounds and organic chemistry may therefore be defined as the chemistry of the compounds of carbon, as they are found in Nature or have been syn- thesized in the laboratory. At the present time approximately 300,000 com- pounds of carbon are known while the compounds of all the other elements combined number only about 26,000. Organic chemistry is also defined as the chemistry of the hydrocarbons and their derivatives. In the last few decades organic chemistry has made rapid progress, even to the point of producing substances which have no counterpart in Nature, as plastics, for example. Today it plays an important part in industry for the organic chemist produces antiseptics, drugs, explosives, and perfumes from coal-tar, converts cotton and wood into paper, artificial silk, explosives, photo- graphic films, and celluloid, and prepares leather, soap, sugar, paints and varnishes, synthetic plastics and resins, rubber, and linoleum. Organic chem- istry makes it possible to understand the changes that take place in the making of jam, the baking of bread, the brewing of beer, etc., and to correctly understand physiology and the chemical processes that occur in the healthy, 714 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY as well as the diseased body, a knowledge of that branch of organic chemistry known as physiological chemistry is necessary. As a source of organic compounds Nature is unequalled for not only are they formed in the growth of animals and plants but they exist in and are obtained from substances that once were living animals and plants. Starch, sugar, cellulose, vegetable acids, fats, proteins, alkaloids, etc. are examples of organic compounds formed in the growth of plants and animals. By natural processes of decomposition or by laboratory methods many of these substances are broken down into simpler forms resulting in additional compounds. Many important compounds are obtained through the process of fermentation, exam- ples being alcohol and vinegar. The destructive distillation of coal, wood, and bones produces a large number of organic compounds. From the destructive distillation of coal are obtained illuminating gas, ammonia products, coke, and coal tar. The latter is especially rich in organic compounds, there being about 200 present in it, among which are numerous phenol bodies, cresols, benzene, toluol, dye bases, etc. In the destructive distillation of wood acetone, acetic acid, methanol (wood alcohol), creosote, charcoal, and tar are some of the products. The destructive distillation of bones produces ammonia and of- fensively smelling substances used to denature other substances. Petroleum contains many compounds of carbon and hydrogen. The methods used in the study, analysis, and synthesis of organic compounds are too complex for discussion here. Two distinct divisions or types of carbon compounds, or hydrocarbons, exist: 1. The aliphatic or open-chain series; and 2. The aromatic, carbocyclic, or closed- chain series. The word aliphatic is derived from a Greek word meaning fat, oil, and the aliphatic series consists of an open chain of carbon atoms, represented structurally as follows: Ethane The aromatic series is characterized by a closed chain of carbon atoms known as the benzene nucleus or benzene ring, represented structurally as follows: Benzene The aromatic series can be further divided into two groups, one of which, called the polymethylenes, exhibits properties closely resembling those of the aliphatic series, while the other exhibits properties differing in many respects from the aliphatic and polymethylene compounds, and is the true aromatic series. Structure and structural formulas of carbon compounds.—In the discussion of rhe element carbon on page 705 its valence is given as IV, shown structurally as: CHEMISTRY 715 and which means that it requires four monovalent atoms for saturation. It was also explained that carbon atoms possess the property of self affinity, being capable of combining with each other to form long chains. This property is shown structurally as: and is always true unless the saturation bonds are united with some other element. In the writing of these structural formulas it should be remembered that when two carbon atoms are shown as C — C—, the single bond uniting 1 1 the two C’s actually represents one bond from each carbon atom joined together. Also, as in the formula of benzene shown before, where no bond uniting a hydrogen atom with a carbon atom appears, it is considered that a single bond representing one bond from the hydrogen atom and one from the carbon actually exists but has been omitted for convenience in writing the formula. The formula of benzene showing all bonds appears on page 722. When a carbon atom or group of carbon atoms is found in such a state that all bonds are not occupied, it is said to be unsaturated. Consequently compounds containing such groups are also unsaturated, and are capable of taking on additional atoms and radicals. In these groups the carbon atoms may be likened to the nucleus of an atom, and the various atoms saturating the bonds represent the electrons. The number of unsaturated bonds is equal to and identical with the group’s valence: Valence I Valence II When all the bonds of the group are satisfied, its valence being zero, a saturated compound results. In organic chemistry the carbon atoms, as a rule, unite with hydrogen to form hydrocarbons. The hydrogen atoms are readily replaced by monovalent atoms or groups to form substitution or addition compounds: Methane Methyl iodide Methyl alcohol Ethyl alcohol Isomerism.—When analyzing organic compounds their molecular weight and the ratio of the atoms composing them is expressed by empirical formulas, as CzELiO for example. As there are two substances which have the composition and molecular weight represented by this formula, it is evident that the formula must be written in two different ways if each compound is to be dis- tinctly represented. To do this the formula for one substance, which has many of the properties of a hydroxide, is written O2H5.OH, while that for the other, which is an oxide, is written (CH3)20. Formulas of this type are known as rational formulas. (For a general discussion of formulas see p. 661.) In the study of organic substances the chemist endeavors, by means of graphic or structural formulas, to show the chemical properties possessed by a 154294°—39 16 716 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY substance, in order to definitely distinguish between compounds having the same percentage composition and molecular weight. That there are many such compounds is evidenced by the fact that more than 100 compounds with the formula CaHnNCh have been described. Such compounds are known as isomers and the phenomenon of the existence of such substances is termed isomerism. In seeking an explanation of this phenomenon chemists concluded that, if the molecules of two substances con- tain the same number and kind of atoms in the same relative proportions, the difference in properties exhibited by the two substances must be due to a difference in the arrangement of the atoms within the molecules. Thus, the two compounds having the formula C2H0O are isomers, and to distinguish between them, the chemist, in a structural formula, shows the different arrangement of the atoms within each molecule as follows: Ethyl alcohol Di-methyl ether Compounds having the same percentage composition but different molecular weights are known as polymers and this condition of compounds is termed polymerism. Thus, benzene, CeHs, is a polymer of acetylene, C2H2. Homologous series.—By observing the structural formulas of methane and H ethane it will be seen that in the formula for ethane there is one more C group H than in the one for methane. By the addition of similar groups other com- pounds are formed as: Propane Butane and by continuing the procedure a considerable number of hydrocarbons can be obtained. It will be noticed that each compound differs from the ones next H to it by one i group, and the molecular formulas of these substances, methane, H CIL, ethane, C2Ho, propane, C3Hs, and butane, CJLo, show a like difference of one CH2 group. A group of such compounds is known as a series and each compound as a member of the series. A series of compounds in which the members have similar chemical properties and each successive member differs in composition by a constant increment of CH2 is termed a homologous series, the relationship is homology, and any member in the series is a homologue of any other member in it. CHEMISTRY 717 This principle not only applies to the hydrocarbons but to their derivatives as well: Methyl chloride Ethvl chloride Propyl chloride That such a series can be built up is due to the fact that, in the methane series for example, one hydrogen atom, El, can be replaced by a CEL radical, H —C—H; by taking one hydrogen atom from the formula for methane, CEL A there is left OH* and replacing this hydrogen atom with the radical CEL gives CaHe, the formula for ethane. (See p. 714.) The fact that it is possible to classify the hydrocarbons into a small num- ber of homologous series greatly simplifies their study. This classification is based on the chemical properties of the different hydrocarbons, which is de- termined largely by the relation between the carbon and hydrogen atoms in the molecules. When brought into contact with other substances a great many hydrocar- bons are very inactive, being little affected by concentrated sulfuric acid and nitric acid and resisting the action of strong alkalies and most oxidizing agents. Under certain conditions these hydrocarbons will react with chlorine and bromine and their hydrogen is replaced by the halogen. Certain hydrocarbons having these properties are classified in the series known as the paraffins (de- rived from Latin words meaning little affinity). This series is also known as the methane series, because methane is the simplest member of the series, and as the marsh gas series, because methane, a gas, is formed when dead leaves, grass, etc., disintegrate in stagnant pools of water in marshes or swamps, the gas rising in bubbles in the water when the decaying mass is stirred. The methane series is one of the principal homologous series of hydro- carbons, and the first eight members in it are: Name Formula Name Formula Methane cn4 C2H6 C3H& C4H10 C5H12 CoH,4 C?H,6 CgHis Ethane . Propane __ __ As each member of the series differs from its preceding member by a definite and constant increment of CEL, a general formula can be used to represent that increment as: CaH2n+2, n equalling the number of carbon atoms combined. Ethane, the second member of the methane series, contains 2 combined carbon atoms, and therefore: C2H(2xj)+3=C2H8. An easier method is to “add 12” to the subscribed numbers in the formula of the preceding member, using the 1 for the carbon atoms and the 2 for the hydrogen, thereby increasing the number of carbon atoms by 1 and the number of hydrogen atoms by 2. 718 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The chief source of the methane series of hydrocarbons is petroleum, from which they are obtained by fractional distillation. The lower members of this series consist of gases which are dissolved in the middle or liquid members of the series. The higher members are solid forms and also are dissolved in the liquid portion. These hydrocarbons also may be obtained by dry distillation of many other organic substances, such as bituminous coal, shales, and wood. Methane, CH4, is the only hydrocarbon containing but one carbon atom. It is found in petroleum and also occurs as a by-product from decomposing vege- table material, especially at the bottom of marshes and pools. Methane is a colorless, odorless gas, burning with a pale, faintly luminous flame, and forming an explosive mixture with air. It may be prepared in the laboratory by heating a mixture of anhydrous sodium acetate and soda-lime. Illuminating gas, manufactured from coal, contains 30 to 40 per cent of methane. Ethane, CaHn, is found in crude petroleum and natural gas. It is a colorless, odorless gas, burning with a pale flame. It may be prepared by the action of zinc or sodium upon methyl iodide: CH3I + Nal 2N t , 19Hs CH3I + Na/^2Nai + |(lH3 This building up of complex molecules from simpler ones is synthesis. Propane, normal butane, pentane, and hexane occur as liquids in crude petroleum, the latter two especially being present in gasoline. The hydrocarbons from Oi«Hm on are solid at ordinary temperatures and comprise the bulk of petrolatum products. A mixture of still higher hydrocarbons constitutes the commercial paraffin. Hydrocarbon derivatives. Halogen substitution products are derived from the hydrocarbons by replacing one or more of the hydrogen atoms with halogen atoms. {See p. 215.) Chloroform, CHCh, (trichlormethane), is a comparatively heavy liquid with an ethereal odor and sweetish taste. It is noninflammable, very slightly soluble in water, and boils at about 61° C. Chloroform is prepared by treating acetone or ethyl alcohol with chlorinated lime. It is good solvent and a general anaesthetic. CHS Ethyl chloride, | is a colorless, extremely volatile, inflammable liquid CH2CI having a pleasant ethereal odor and boiling between 12° and 13° 0. It is prepared by treating ethyl alcohol with hydrochloric acid. In minor surgery ethyl chloride spray is used to anaesthetize local areas by freezing. It is also a general anaesthetic. Alcohols.—An alcohol is derived from a hydrocarbon by substituting a hy- droxyl group (OH) for one or more of the hydrogen atoms. Alcohols con- taining one OH group are monohydroxy alcohols. Those containing two OH groups are dihydroxy alcohols, etc. {See p. 218.) OH Methyl alcohol, J is a colorless liquid with a peculiar odor, burning with CH3 a nonluminous flame. It boils at 66.7° C. It is poisonous and blindness and death may result from its internal use. Methyl alcohol or “wood spirit” is obtained from the dry distillation of wood (wood alcohol) and is also prepared synthetically in large quantities under the name of methanol. It is an excellent solvent for fats, oils, and resins. CHEMISTRY 719 CH3 Ethyl alcohol, | ., is a colorless, inflammable liquid with a pleasant CH2OH odor, and at 95.57 per cent strength it has a boiling point of 78.3°C. It burns with a nonluminous flame and its vapors, when mixed with air, explode when ignited. Ethyl alcohol is obtained by the fermentation of grain or fruit with subsequent distillation. It is one of the best solvents and is the starting point in the manufacture of many such useful compounds as ether, chloroform, and iodoform; large quantities are used in the preparation of varnishes, per- fumes, and tinctures of drugs. It is not poisonous although when taken to excess in strong beverages the effect on the system is distinctly injurious. The general group CH2n+i, is termed the “alkyl radical group”. Individual radicals take their names from the corresponding hydrocarbons, as CH3, the methyl radical, and C2H5, the ethyl radical. Aldehydes.—An aldehyde is derived from a hydrocarbon by substituting an oxygen atom for two hydrogen atoms on a terminal carbon atom. {See p. 220.) 0 Formaldehyde, J| , is a gas of extremely pungent odor, which reduces cold CH2 ammoniacal silver solution. It is prepared by passing a mixture of gaseous methyl alcohol and air over gently heated copper oxide. It is valuable as an antiseptic, fumigating agent, and preservative. Undertakers use a solution of formaldehyde of about 40 per cent in water for embalming. Acetaldehyde, is a colorless, mobile liquid, having a marked characteristic odor and boiling at 21° C. It is prepared by the oxidation of ethyl alcohol with a mixture of dilute sulfuric acid and potassium dichromate. Ketones.—A ketone is derived from a hydrocarbon by substituting an oxygen atom on a carbon atom other than a terminal one in place of two hydrogen atoms. Acetone, is a colorless liquid with a somewhat pleasant ethereal odor. It is very soluble in water and boils at 56.6° 0. The chief use of acetone is as a solvent and it is prepared by the distillation of calcium acetate: Ethers.—An ether is an alkyl oxide, that is, two alkyl radicals such as CH3 or C2H5 are attached to an oxygen atom. {See p. 221.) Ethyl ether, (commonly called sulfuric ether be- cause sulfuric acid is used in its preparation), is a transparent, mobile liquid with a characteristic odor and a burning sweetish taste. It is some- what soluble in water (1 —10) and boils at about 35° C. The vapor is very in- 720 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY flammable and forms an explosive mixture with air. Ethyl ether is the most important general anaesthetic. In commerce its chief use is as a solvent. The ethers are prepared by treating alcohols with sulfuric acid and con- densing the vapors. Organic acids.—An organic acid is derived from a hydrocarbon by sub- stituting an oxygen atom and a hydroxyl group for the three hydrogen atoms of a methyl radical, CHS, thus forming a carboxyl group, COOH, which is common to all organic acids. {See p. 225.) Acetic acid, is a clear, colorless liquid with a very penetrat- ing, acid odor and sharp burning taste. It boils at 118° C. and mixes with water in all proportions. It is produced by the oxidation of alcohol in fermented liquors due to the presence of a microscopic organism, the My coderma aceti. It may also be obtained from the dry distillation of wood. Vinegar contains 4 per cent of acetic acid. Fats or animal and vegetable oils, are esters of organic acids. Soaps are the metallic salts of organic acids Esters.—An ester is derived from an organic or inorganic acid by replacing the carboxyl hydrogen in organic acids, or the ionizable hydrogen in inorganic acids, with an alkyl radical. {See p. 226.) Ethyl acetate, is a transparent, colorless liquid with a fragrant and refreshing odor and a peculiar acetous, burning taste, moderately soluble in water and easily soluble in alcohol and ether. It is inflammable and burns with a yellowish flame and acetous odor. Its most important use is as a solvent. Ethyl nitrite, is a mobile liquid having a penetrating ethereal odor and peculiar stinging taste, boiling at 18° C. and burning with a bright white flame. Its alcoholic solution is Spiritus ASthylis Nitritis, XL S. P., commonly known as sweet spirit of niter. Ethyl nitrite is prepared by the action of sulfuric acid upon a mixture of sodium nitrite and alcohol. If the alkyl radicals in a compound are designated by the letter R the various hydrocarbon derivatives may be represented by the following formulas: Derivative General formula Derivative General formula ROH RCHO RCOR Acid RCOOH RCOOR ROR Ether__. .. ... Carbohydrates.—Among the important derivatives of the open-chain series of hydrocarbons are the saturated compounds known as carbohydrates. These compounds are produced in the growth of all green plants by the process of CHEMISTRY 721 photosynthesis and constitute a major class of foods for animals. The name originated in the fact that they contain the elements carbon, hydrogen, and oxygen and their elementary composition may be expressed by the general formula CH>0, the latter two elements being in the same proportion as they are in water. There are, however, true carbohydrates in which this ratio of hydrogen to oxygen does not exist and other compounds that are not carbo- hydrates in which it does exist and to such compounds the term carbohydrate is therefore not strictly applicable. Notwithstanding these facts it continues to be used as the name of this class of compounds for it is too well fixed in chemical nomenclature to be displaced. {See p. 241.) Typical carbohydrates are sugars, starches, and cellulose. Their molecules are very complex and study of this class of compounds has shown that they are in general aldehyde or ketone alcohols, or compounds which are converted by hydrolysis into those types of alcohols. The carbohydrates are also known as saccharides and may be divided into two classes, the monosaccharides, which do not hydrolyze, and the polysac- charides, which can be converted into monosaccharides by hydrolysis. When a monosaccharide contains the aldehyde group it is known as an aldose and when it contains the ketone group it is known as a ketose. Monosaccharides are also classified according to the number of carbon atoms in the chain as dioses, trioses, tetroses, pentoses, hexoses, etc. The simpler carbohydrates are also called simple sugars, which are named as are the monosaccharides and are polyhydroxy derivatives of saturated aldehydes and ketones. The complex sugars, the starches, and cellulose, all of which are polysaccharides, consist of 2, 3, or many such simple sugars united into a single molecule. The structural formula of glucose, a hexose sugar, is as follows: Tlnsaturated hydrocarbons. Associated with the saturated hydrocarbons in petroleum is a series of hydro- carbons each member of which contains two hydrogen atoms less than the corresponding member of the saturated series. They possess the general formula CnH2n and are known as the olefin series. Hydrocarbons of this series are also known as the ethylenes, from the first member of the H H series, ethylene, H— —H. They contain one unsaturated linkage which is indicated structurally by a double bond placed between two of the carbon atoms as shown in the formula of ethylene just given. Their most characteristic reaction is the direct combination with two atoms of halogens to form “addition compounds”. An example is the combination H H I I of two atoms of bromine to form ethylene bromide, H—C—C—H, They Br ir have been named by adding the termination “ene” to the monad radicals derived from the corresponding saturated hydrocarbons. In their physical properties they resemble the methane homologues closely. 722 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Hydrocarbons containing two hydrogen atoms less than the corresponding member of the olefin series and four less than the same member of the paraffin series are known. They may belong either to the allenes containing two double H H linkings, such as allene, H— Ui —H, or to the acetylenes containing one triple linking, such as acetylene, H—C=C—H. The names of some of the members of these series are given in the following table: Ethylene series CnHjn Acetylene series CuH2a-2 Name Formula Name Formula Ethylene Propylene Butylene Pentylene Hexylene.-. Heptalene Octalene C2H4 c3h8 C4H8 C5H10 CeHia C7H,4 CsHis Acetylene. ... Propine. Butine.. Pentine Hexine Heptine Octlne C2H2 C8H4 c4h6 c6h8 CgHio C7H12 C8H14 Aromatic hydrocarbons. The derivatives of methane and similar hydrocarbons have one common feature in that they are open-chain hydrocarbons, or aggregates of carbon atoms linked together in such a way that the end carbon atoms are distin- guished from those occupying a middle position in the molecular grouping. In the aromatic series of hydrocarbons it is considered that the molecule contains six carbon atoms linked together in a closed chain so that no one of the six is an end carbon atom. The fundamental hydrocarbon of this series is benzene, the structural formula of which is shown on page 714. Before continuing with the discussion of the aromatic hydrocarbons a brief explanation of the benzene ring is essential. If the structural formula of benzene is so written as to show all bonds linking the carbon and hydrogen atoms together it will appear as: This is a cumbersome method and for convenience a simple oblong hexagon is ordinarily used. At each angle of the hexagon it is assumed a CH group is situated and the hexagon so written is always understood to mean CcHe. The hydrogen atoms in benzene are replaceable by the substitution of other elements or groups, and when only a single hydrogen atom is replaced, as in the formation of phenol from benzene, the replacing OH group may be shown OH at any angle of the hexagon but usually is placed at the top, as which V CHEMISTRY 723 it is understood to be CoHsOH, or phenol. (See p. 222.) If, however, two hydro- gen atoms are replaced it is necessary to know at which angles to place the replacing element or group. To facilitate this the angles of the hexagon are given imaginary numbers starting with 1 at the top and proceeding clock- wise, thus: Replacement or substitution of two hydrogen atoms can take place in three different ways, to form three isomeric compounds, as shown in the following structural formulas where the OH group is again used as the substituent: Each of the compounds shown, in which 2 hydroxyl groups are substituted for 2 hydrogen atoms, is dihydroxybenzene, but to designate the structure the figures of the substitution places or the prefixes ortho, meta, or para are added. Thus the first compound shown is known either as 1-2 or ortho, the second as 1-3 or meta, and the third as 1-4 or paradihydroxybenzene. Substitution of three hydrogen atoms in the benzene ring also gives three isomeric compounds as follows, with OH as the substituent: The substituent groups in the compounds shown are said to be vicinal (adjoin- ing or consecutive), in the one at the left, asymmetrical in the one in the center, and symmetrical in the one at the right. These isomeric compounds, all of which are trihydroxybenzene, are designated by numbers or by the first letters of the words indicating the positions, as 1-2-3 or v-, 1-2-4 or a-, and 1-3-5 or s-trihydroxybenzene. For further information concerning the benzene ring reference should be had to any standard text book on Organic Chemistry. Resuming discussion of the aromatic series, homologues of this series are formed by the replacement of one or more of the hydrogen atoms by methyl and ethyl groups; The limit of this replacement is reached when other atoms or groups have been substituted for the six hydrogen atoms. Both the hydrocarbons of this series and the substitution derivatives are quite stable. 724 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The benzene derivatives are not convertible into methane derivatives by the addition of halogens or other atomic groups; benzene, CbHo, cannot be converted into hexane, CsHw, by any means, direct or indirect. In fact, it is strikingly evident that OsHe is a peculiarly constituted molecule, which resists change and remains substantially intact through all the substitutions that may be effected. It cannot be transformed into a simple molecule containing 5, 4, or 3 carbon atoms; when oxidized, it reverts into carbon dioxide and water. More than half of all the carbon compounds are benzene derivatives. Among the important derivatives is nitrobenzene which is prepared by treating benzene with nitric acid. Nitrobenzene is reduced by nascent hydrogen to aniline, from which the “aniline dyes” are derived. The general formula for the benzene series is represented aS CnH2n—6« The scope of Organic Chemistry is practically unlimited and in this chapter it has not been possible to give more than a very brief outline of this most interesting subject. As has been previously stated many hundred times more compounds than Inorganic Chemistry contains are already known, and what future research in this realm may produce is purely a matter of speculation. ANALYTICAL PROCEDURES The division of chemistry which deals with the composition of substances is called Analytical Chemistry and its procedures are known as chemical an- alyses. It is divided into two parts: 1. Qualitative analysis, in which the constituents in a given compound are identified; and 2. Quantitative analysis, in which the percentage of various elements or compounds is determined. The methods used to make these determinations are based upon the simple laws of chemistry and the similarity of properties and reactions existing among certain groups of elements and their compounds. Because the molecules of a substance necessarily must have intimate con- tact to facilitate a complete reaction, the substance to be analyzed is first dissolved in a liquid, usually water. This induces the substance to dissociate into its various ions. The determinations in chemical analysis are based upon the conduct of these ions and their reactions with various reagents, and therefore a knowledge of the theories and laws of ionization as related to the various elements and reagents employed is necessary. A brief discussion of ionization as regards its use in chemical analysis will follow. The first step in proceeding with a chemical analysis is either to isolate the various components to be determined by precipitation of their ions and subsequent filtration, or to treat their solution in such a manner that their reaction with the indicated reagents is not modified or obscured. Pure water freezes at 0°C., but when a substance is dissolved in water the freezing temperature ordinarily is depressed in proportion to the amount added. It is evident, therefore, that the depression of the freezing point of water is proportional to the number of molecules of the substance dissolved in a given CHEMISTRY 725 quantity of water. For example, if a mole {see page 663) of alcohol (46 Gms.) is dissolved in sufficient water to make 1,000 cc, the freezing point is lowered 1.86° C. Similarly, one mole of many other substances, such as sugar or glycerin, when dissolved in sufficient water to make 1,000 cc, depresses the freezing point of the water 1.86° C. Acids, bases, and salts, in the same equivalent proportion, cause the freezing point of water to be depressed even more than 1.86° C., in many cases as much as 2, 3, or 4 times. In dissolving one mole of Nad in sufficient water to make 1,000 cc of water, the freezing point is lowered nearly 2 times 1.86° O. From this fact it might seem that there are twice as many particles present in the solution from a mole of NaCl as there are from a mole of alcohol, but as a mole of one substance contains the same number of molecules as that of any other substance, there therefore cannot be twice as many molecules of NaCl as there are of alcohol. Consequently, it becomes evident that the molecules of NaCl split into two particles. One molecule of BaCb dissolved in sufficient water to make 1,000 cc depresses the freezing point of the water nearly 3 times 1.86° C., and hence it is obvious that its molecules have split into 3 distinct particles. Further evidence of this splitting process is the precipitation of AgCl when AgNOs is added to a solution of NaCl or BaCb. This precipitation will occur with any chloride regardless of what active metal is combined with the Cl. Therefore, it is apparent that the characteristics of a solution are to some extent due to the functions of the constituent parts of the salts, rather than the molecules of the salts as a whole. In like manner all acids exhibit the same properties which classify them as acids (turn litmus red, have a sour taste, decompose carbonates) regardless of what elements or groups of elements are combined with the hydrogen which is common to all acids. This shows that the properties of an acid are dependent upon its hydrogen, for that is the only element common to all acids; the other elements combined with hydrogen in acids have extremely different properties. The characteristic properties of all the bases in solution are derived from the hydroxyl radical, (OH), which is the only unit common to all bases. These facts demonstrate that acids, bases and salts, when dissolved in water, split up into their constituents in the following manner: hci +cr +OH~ HaCl <=?Na+ + C1- H2S04 + H+ + SOr - BaCl2 + Cl- + Cl- The hydrogen formed when an acid splits up in solution behaves quite differently from that found in the gaseous state or in compounds such as the hydrocarbons. Likewise, the sodium formed is quite different from metallic sodium which reacts violently with water. This is because these particles, called cations or anions according to their nature, carry electric charges, and when they come in con- tact with the cathode or anode electrode, as the case may be during the proc- ess of electrolysis, they give up their electrical charge and assume their natural state. (See previous discussion of electrolysis.) Substances which per- mit the passage of an electrical current through their solutions, and which, from the consideration of their depression of the freezing point, do split into their constituent parts, are known as electrolytes. Substances which do not permit the passage of electrical current through their solutions and give normal 726 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY freezing point depressions (1.86° C. per one mole in sufficient water to make 1,000 cc) are known as non-electrolytes. From these observations the theory of electrolytic dissociation, or ionization, has been developed, in which it is considered that: 1. When an acid, base, or salt is dissolved in water it instantly separates or dissociates into particles called ions; 2. These ions are electrically charged, hydrogen and the metals carrying posi- tive charges and the non-metallic elements and radical groups except NH*, carry- ing negative charges. The total of the positive and negative charges is equal, that is, they balance each other; and 3. When oppositely charged ions in a solution collide they reform, for an instant, molecules of the original substance. The process of ionization is there- fore reversible, and is indicated by double arrows <=*. The solution will con- tain, at a given instant, a definite number of whole molecules along with the ions. Ionization is not complete until the solution is so greatly diluted that collision of the ions rarely occurs. The number representing the percentage of molecules ionized at a given instant is called the degree of ionization. Thus, if at a given instant, 90 out of every 100 molecules of a substance are ionized and 10 still exist as whole molecules, the degree of ionization is 0.90 or 90 per cent. Acids, such as HC1, HNOs and H2SO4, which have a high degree of ioniza- tion (0.50 to 0.90) in normal solutions are called strong acids. Other acids, such as H.C2H302, H2S and H2C03, which are ionized very slightly (less than 0.1) in normal solution are known as weak acids. There is, however, no very distinct demarcation between weak and strong acids, all acids being completely ionized in very dilute solutions. Bases, such as NaOH and KOH, which have a high degree of ionization in normal solutions are called strong bases. Those having a low degree of ionization, such as NHtOH, are called weak bases. Nearly all the soluble salts are highly ionized, even those derived from weak acids. When ions are removed from a solution by the addition of another sub- stance, the relative velocity at which the molecules break up to form new ions will be increased, although the number of ions present at a given instant will remain the same. For example, HC1 is normally ionized 80' per cent, in a normal solution, into positive hydrogen (H+) and negative chlorine (Cl-) ions. If a mole of NaOH is added to the solution, the H+ ions unite with the OH~ ions derived from the NaOH to form H20 which is very slightly ionized. Therefore, the H+ ions are removed from the solution. HC1 is constantly ionizing, but the OH~ ions continuously remove the H+ ions from the solution, preventing the reforming of HC1 molecules. As a result, the HOI molecules are progressively broken down until no more molecules of HC1 remain. In the same way the ions of NaOH undergo a like process. When there are no longer molecules of HCl or of NaOH left to ionize, the solution exhibits neither the properties of an acid nor a base; hence it is termed neutral. The reactions which take place are indicated by the following equation: HClfc? ir +C1- _l_ -j- OH-+Na+ it it H20 NaCl Standard solutions are those which contain a known and definite amount of a given substance. They are divided into two classes, molar and normal. CHEMISTRY 727 Molar solutions.—The concentration, or quantity of solute a solution con- tains, is often an important factor in chemical reactions. The ratio of solute to a definite volume of solvent is usually expressed in grams per 1000 cc, ounces per quart, or pounds per gallon. These are convenient arbitrary units selected by man. On the other hand there are certain units which are constant in Nature and must be considered in chemical reactions, for, in truth, chemistry is a duplication, by man, of natural processes. The natural unit of an element is the atom and is the unit which is exchanged in chemical reactions. In the case of compounds the natural unit is the molecule. Therefore, the natural unit of weight in a chemical reaction is the actual weight of each individual atom concerned. It is readily apparent that the actual weights of the atoms and molecules are too small for convenient use. The actual weight of a hydrogen atom has been determined as 0.000,000,000,000,000,000,000,001,662 Gm., and that of oxygen as 0.000,000,000,000,000,000,000,026,4 Gm., the latter being nearly 16 times the former. Due to the impracticability of working with such volu- minous figures, relative weights rather than absolute weights are used. The relative weights are the same regardless of the number of atoms compared. Thus, one atom of oxygen is nearly 16 times as heavy as one hydrogen atom; 2 oxygen atoms are nearly 16 times as heavy as 2 hydrogen atoms, etc. One gram of hydrogen contains a definite number of hydrogen atoms. To acquire the same number of oxygen atoms it would be necessary to have nearly 16 Gm. of oxygen. Therefore, the relative atomic weight of an element in grams contains the same number of atoms regardless of what element is considered. The calculation of the relative atomic weights is based on oxygen (0=16) as the arbitrary standard; then 16 Gm. of oxygen contain the same number of molecules as 1.0078 Gm. of H; 22.99 Gm. of Na; 32.06 Gm. of S; 35.457 Gm. of Cl; etc. One molecular weight in grams is called a mole. A solution containing one mole of solute in 1,000 cc of the solution (not the solvent) is termed a molar solution. Such molar solutions are designated by the abbreviations M/l or H- and solutions containing one-half mole, one-tenth mole, etc., in 1,000 cc, as M/2 orM, M/10orM, etc. One mole of any substance contains the same number of molecules as a mole of any other substance. Hence, a mole of a given substance has the exact number of molecules necessary to react completely with one mole of another substance, or with a definite multiple or fraction thereof. Thus: H2S0 + H+ +S04- - + + + + Na+ + Na+ it it 2H20 Na2S04 In this reaction one molecule of H2S04 combines with two molecules of NaOH to form a salt and a neutral solution; or one mole of H2S04 reacts with two moles of NaOH. With a molar solution of NaOH and a molar solution of HC1, it will take the entire liter of NaOH solution to neutralize the liter of HC1 solution, or 1 cc of NaOH solution to neutralize 1 cc of HOI solution. Molar solutions are convenient because 1 cc of a molar solution of one substance will neutralize 1 cc or 2 cc or 3 cc or % cc or % cc or % cc of a molar solution of some other substance. The reaction between NaOH and H2S04 demonstrates why the numbers are not always 1:1. 728 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY It is obvious that it would be more convenient to have all standard solu- tions neutralize each other cc for cc rather than in multiples of 2, 3, 4, etc. This can be accomplished by the use of normal solutions. Normal solutions.—Solutions which contain 1.0078 Gm. of replaceable hydrogen or its equivalent weight of solute in 1,000 cc of solution are termed normal solutions. It has been noted that all acids derive their characteristics from the ionizable hydrogen which they contain, this hydrogen being readily replaceable by active metals. In preparing a normal solution of an acid, it is necessary to consider the number of hydrogen atoms contained in the molecule. As the molecular weight is derived from the sum of the atomic weights, it is con- venient in preparing standard solutions to use the molecular weight in grams. To prepare a normal solution of HC1 first note that the molecular formula shows 1 replaceable atom of hydrogen and that the molecular weight is 36.465 Gm. in which 1.008 Gm. is the weight of 1 atom of replaceable hydrogen; therefore, 36.465 Gm. of HC1 is to be dissolved in sufficient water to make 1,000 cc. In preparing normal solutions of acids containing more than 1.008 Gm. of replaceable hydrogen, it is necessary to use that portion of the molecular weight in grams which will represent 1.008 Gm. of replaceable hydrogen. For example: H2SO4 contains 2 replaceable hydrogen atoms and its molecular qo weight is 98.07; therefore, - — -—>49.03 Gm. of H2SO4, or the equivalent of /u 1.008 Gm. of H% must be used. HsPO* contains 3 replaceable hydrogen atoms qo ni and its molecular weight is 98.04 Gm.; therefore, Gm. of II1PO4, O or the equivalent of 1.008 Gm. of H+, must be used. For convenience in designating a normal solution the abbreviation N/l or N — is used. In normal solutions or fractions of normal, appropriate numbers are placed below or after a line next to the letter N. Thus, a half normal solution N N Is designated as N/2 or-g-, a fifth normal solution as N/5 ory, a tenth normal N solution as N/10 etc. Solutions which are stronger and therefore are multiples of normal solutions are represented by numbers placed before the letter N. Thus, a double normal solution is designated as 2N, a solution 5 times normal as 5N, etc. In preparing solutions which are fractions of normal, the designated fraction of the molecular weight (or of its proportionate part representing 1.008 Gm. of H+ in 1,000 cc) is used, as, for a N/10 solution of HC1, l/10th of 36.47 Gm. or 3.647 Gm. (the figure in the third decimal place of the molecular weight being dropped and that in the second increased by 1). For solutions which are multiples of normal, the designated multiple is used, as, for a 5/N solution of HC1, 5X46.465 Gm., or 182.325 Gm. Bases do not contain H+ ions but ionize into R++OH" (R being any element forming part of a base), each OH- ion being capable of combination with one H+ ion. In preparing a normal solution of a base the molecular weight (or its fractional part containing OH-, which is the equivalent of one H+) is used. The molecular weight of NaOH, 40.00 Gm., is used in 1,000 cc to prepare the normal (N/l) solution of NaOH. In order to make the H+ equivalent more comprehensive and concise the following formula may be used: __. . . , . molecular weight H+ equivalent weight — , rr- : • total positive valence Then, to prepare a normal solution of an acid containing 1, 2, or 3 replaceable hydrogens the equations would be: CHEMISTRY 729 HC1 ; —36.465 Gm. in 1,000 cc. oft 07 H2S04: -—~ = 49-03 Gm-in i*000 cc.' OS 04 H3P04: ——— — 32.68 Gm. in 1,000 cc. The amount of soluble salts to use in preparing normal solutions may be deter- mined in the same manner, as: ono 07 Ba++Cl,~ : — 104.13 Gm. in 1,000 cc Hydrogen ion concentration and Indicators. It is often desirable to determine the acidity or alkalinity of a solution, or the point of neutrality when the positive hydrogen (H+) ions and the negative hydroxyl (OH") ions are equal. By the use of litmus paper the relative differ- ence between acidity, alkalinity, and neutrality may be demonstrated, but often this procedure is unsatisfactory, in that it does not denote the degree in which these properties are present. Solutions containing a preponderance of H+ ions, as previously stated, are considered acid and solutions containing a preponderance of OH- ions are alkaline, the degree of acidity or alkalinity being dependent upon the number of these ions present. In order to define a definite degree of ionization, either of H+ or OH~, a convenient scale is necessary. In order to have a comparable scale there must be a constant, so, in order to determine the degree of ionization, a scale has been devised using distilled water as a constant, because distilled water has a relatively unappreciabie dissociation into H+ and OH- ions. By electrical-conductivity measurements the degree of ionization of distilled water has been determined as 0.000,000,1, or, to use a negative exponent, 10-7. This means that in 1,000 cc of distilled water there is present only 0.000,000,1 gram of hydrogen ion (H+), the balance of the hydrogen being in the molecular form as H20. Likewise the ionization constant of distilled water has been determined to be 0.000,000,000,000,01 or, to use a negative exponent, 10~14. This ionization constant is the product of the multiplication of the hydrogen (H+) concentration and the hydroxyl ion (OH-) concentration as shown by the following dissociation or ionization equation for distilled water: H+ OH- _Constant (10-7)x(10-7)~ (10-14) Using this factor as a constant, a scale of measure is formulated in terms of potential hydrogen, pH, (ionized hydrogen) to cover the complete range of acidity and alkalinity. The equivalent pH value for any given H+ is the logarithm of that concentrate’s reciprocal. For example: 10,000,000 is the reciprocal of 0.000,000,1 and the log of this is 7 which is the pH value for the H+ concentration of 0.000,000,1. In order to eliminate the unwieldy ciphers the H+ concentrations are ex- pressed by negative exponents. The mathematical calculations by which the pH values are obtained are too complicated, especially in determining the frac- tional parts, to be discussed in this chapter. Inasmuch as H+ concentrations are universally expressed in pH values, which are readily determined, a knowl- edge of logarithms is not necessary to determine the degree of acidity or alkalinity. However, it is to be remembered that the pH values are repre- sented by logarithms, hence, the numerical order in the pH scale is inversely proportional to the H+ concentration it represents. With an increase in pH 730 HANDBOOK OF THE HOSPITAL CORPS, II. S. NAVY values from 0 to!4 there is a decrease in H+ concentration with a correspond- ing increase in OH' concentration to maintain the equilibrium of 10"14, the ionization constant of H20. At pH 7.0 there is an equal number of H+ and OH" ions, the concentration in each group being 10"7 hence, pH 7.0 is the neutral point. A decrease in pH from 7 to 0 is accompanied by a progressive increase in H+ ions, and in acidity, with a decrease in OH- ions. An increase in pH from 7 to 14 is accompanied by a progressive decrease in H+ ions with an increase in OH" ions, and in alkalinity. Because logarithms are used, in the pH scale it is to be noted that pH 6 represents 10 times as many H+ ions as pH 7, and that pH 5 represents 100 times as many H+ ions as pH 7, etc. pH Scale Hydrogen ion concentration pH value Hydroxyl ion concentration 1.0 or 10-° pH 0.0 IO-14 or 0.00000000000001 0.1 or 10-1 pH 1.0 10-13 or 0.0000000000001 0.01 or 10-2 pH 2.0 IO-12 or 0.000000000001 0.001 or lO"3 pH 3.0 IO-11 or 0.00000000001 0.0001 or IO-4 pH 4.0 IO-10 or 0.0000000001 0.00001 or 10-5 pH 5.0 10-9 or 0.000000001 0.000001 or 10-6 pH 6.0 10-8 or 0.00000001 0.0000001 or 10“7 pH 7.0 10-7 or 0.0000001 0.00000001 or 10-* pH 8.0 10-6 or 0.000001 0.000000001 or 10-9 pH 9.0 10-5 or 0.00001 0.0000000001 or IO-10 pH 10.0 lO"4 or 0.0001 0.00000000001 or 10-ii pH 11.0 10-3 or 0.001 0.000000000001 or 10-12 pH 12.0 10-2 or o.Ol 0.0000000000001 cr IO-13 pH 13.0 10-1 or 0.1 0.00000000000001 or lO-'4 pH 14.0 10-6 or 1.0 Hydrogen ion determinations are made either electrochemically or col- orimetrically. Electrical-conductivity tests for the quantitative determination of H+ ions require elaborate apparatus and special training, whereas colori- metric determinations may be made comparatively accurately and conven- iently with inexpensive apparatus, buffer solutions, and indicators. A buffer solution is one that has a definite concentration of hydrogen ions (H+) which is not altered by dilution, and is prepared by dissolving definite weights of the salts of weak acids and of weak bases or of both in sufficient water to make 1000 cc. As a rule, two buffer solutions are used in con- junction, one containing a preponderance of H+ ions and the other a preponder- ance of OH- ions. By mixing prescribed volumes of these solutions together it is possible to produce a solution of any desired pH value. Due to the low ionization value of the substances used, the H++OH~ equilibrium is maintained under ordinary circumstances and the pH value of their combination remains constant. For detailed preparation of buffer solutions refer to “Clinical Diagnosis by Laboratory Methods”, Todd and Sanford, p. 668. Indicators are natural or synthetic organic substances used in chemistry to show by a color change whether a substance is acid or alkaline in reaction. A familiar example is blue litmus which turns red with acids and is unchanged with alkalies. To determine the pH value of a given solution, a range of known pH values is prepared with buffer solutions contained in a series of test tubes, to which is added an indicator that will cover the pH range desired. An equal amount of indicator being added to each tube, a distinct and progressive range of colors develops. An equivalent amount of indicator is added to a proportionate part of the unknown solution and the resulting color compared with the known CHEMISTRY 731 range, the pH value of the unknown solution being identical with that of the tube whose color it matches. Following are some of the more common indicators used and the pH range they cover: Indicator pH range Color change Acid Alkaline Brom-phenol blue 3. 0- 4. 6 4.4- 6. 0 6. 2- 6. 8 6. 0- 7. 6 6.8- 8.4 7. 2- 8. 8 8.3-10.0 Yellow Red Blue. Y ellow. Purple. Blue. Red. Red. Red. Brom-cresol purple . Brom-thymol blue_ Yellow Yellow Yellow Yellow Phenolphthalein Colorless Phenolphthalein is one of the most common indicators used, especially in titrating acids and alkali hydroxides. However, care must be employed in the choice of an indicator, as some are affected in the chemical reactions used for analysis, e. g., when titrating carbonates and ammonium compounds phenolphthalein cannot be used. In titrating carbonates methyl orange is used. In ammonia titration cochineal is used. It is also Important to note if the indicator to be used covers the pH range in which the end-point is to be obtained. are affected in the chemical reactions used Qualitative anaylsis Qualitative analysis is concerned only with the identification of the con- stituents of a compound. As previously stated the elements are divided into the metals and nonmetals. Upon solution, a substance dissociates into ions, the metals forming the positive ions and the nonmetals the negative ions. In determining the character of the positive ions it is found that a number of elements, often elements in the same family, are similar in that one type of their salts is insoluble in water which makes it possible to classify them in groups by precipitation and filtration. After the element has been isolated it is usually identified by its reaction with known reagents or by the color of its precipitate. The negative ions are also identified in a similar manner. Quantitative analysis. Quantitative analysis is concerned with the determination of the percentage of various elements and compounds contained in a substance. Quantitative analysis may be of two types: 1. Ultimate analysis in which the various ele- ments present in a substance are determined, as the determination of sodium, sulfur and oxygen in sodium sulfate; and 2. Proximate analysis in which is determined the groups of elements which act in a similar manner when treated with a reagent or series of reagents, as in determining the amount of insoluble matter in limestone. Quantitative methods of analysis may be performed by gravimetric or volumetric procedures. In gravimetric methods the substance to be deter- mined is isolated, dried, and weighed. In visual volumetric analysis the sub- stance to be determined is titrated against a volumetric solution containing a known quantity of material that will produce a definite reaction with the unknown. The completion of the reaction is signified by an appearance, the disappearance, or a change of color either natural or from an indicator that has been added, or by the end or beginning of precipitation. 154294°—39 47 732 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Visual volumetric analysis is performed by one of the following methods: Acidimetry, in which the percentage of an acid is determined by neutraliza- tion with a standard alkali solution. An indicator is used. Alkalimetry, in which the percentage of an alkali is determined by neutral- ization with a standard acid solution. An indicator is used. lodimetry, in which the percentage of a substance is determined by indirect oxidation through the use of iodine. Iodine is also used in connection with the estimation of other halogens. Oxidimetry, in which the percentage of a substance is determined by direct oxidation through the use of potassium permanganate or some other sub- stance capable of yielding oxygen. In volumetric determinations there are three general types of reactions em- ployed, direct, indirect and residual. In the direct type a known solution is added directly to the unknown until the reaction is complete, as in alkalimetry and acidimetry. The indirect type is used where the quantity of the unknown cannot be con- veniently determined unless it is acted upon by a second substance to form an- other compound which is in proportion to the quantity of the unknown. This second compound is then titrated to find the percentage of the unknown, as in the determination of chlorine. The substance containing chlorine is acted upon by potassium iodide, iodine being liberated in proportion to the amount of chlorine; the iodine is then titrated against a known solution of sodium thiosul- fate, starch paste being used as the indicator. The residual type is used where it is impossible or extremely difficult to ob- tain a reaction between the unknown and the reagents when equivalent quanti- ties are added to each other. Therefore, an excess of the standard solution is added to the unknown to obtain a complete reaction and then a second standard solution is used to titrate the amount of the first solution that remains. The percentage of the unknown is determined from the quantity of the first solution used in the reaction, as in the determination of sodium chloride. A definite quantity of silver nitrate is added in excess to the unknown solution. After the reaction is complete the amount of silver nitrate left from the reaction is titrated against a standard solution of sodium sulfocyanate, ferric ammonium alum being used as an indicator. The amount of silver reacting with the sulfo- cyanate solution is then subtracted from the original quantity added. From this the equivalent amount of sodium chloride is determined. This is known as “back titration”. If it is desired to determine the percentage of sodium hydroxide in a given solution proceed in the following manner: 1. Measure the solution to obtain its volume. 2. Into a 25 cc burette place an N/l solution of hydrochloric acid and bring the meniscus exactly to the 0 mark. 3. Place 10 cc of the sodium hydroxide solution in a 250 cc white porcelain evaporating dish and add 3 drops of phenolphthalein indicator. 4. Allow the HC1 solution to run slowly into the evaporating dish con- taining the NaOH solution, stirring constantly. 5. When the solution becomes visibly paler, add the HCl, a drop at a time, noting the reading on the burette after each addition. When the NaOH solution shows just the faintest tint of pink and the addition of one more drop will make it colorless, the end-point of the reaction has been reached. From the reading on the burette calculate the percentage of NaOH. If the NaOH solution measured 350 cc and neutralization was obtained with 8 cc of HCl, the percentage is calculated in the following manner: 733 CHEMISTRY N/l solution of NaOH contains 40.0 Gm. of NaOH per 1000 ce. 1 ce of N/l HC1 is the equivalent of 0.040 grams of NaOH. Therefore: q^o 8 X 0.040=0.320 Gm. of NaOH in 10 cc, and in 350 cc there areX 0.320= 11.21 Gm. of NaOH. The percentage of an acid is determined in the same manner. Other analytical procedures involve more complicated reactions and for these reference should be made to a standard text on chemical analysis. References General Chemistry.—B. S. Hopkins. General Chemistry.—H. N. Holmes. General Chemistry.—H. G. Deming. A Course in General Chemistry.—McPherson and Henderson. Textbook of Inorganic Chemistry.—J. R. Partington. Organic Chemistry.—J. F. Norris. Modern Chemistry.—F. Prescott. Modern Physics.—C. E. Dull. Physics.—O. M. Stewart. Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. CHAPTEK X ANAESTHESIA Anaesthesia is the state in which total or partial loss or absence of feeling or sensation exists and may be the result of disease or injury, or of the administration of an anaesthetic agent. It is known as general or regional {local), according to the extent of insensibility to pain. The combination of gas-ether anaesthesia is still used extensively, although it is being replaced to a great extent by the cyclopropane-ether-oxygen mixture. Ethylene-oxygen is being used less because it has only a 25 per cent potency, while cyclopropane, with 100 per cent potency, gives the same rapid type of induction and recovery, with deeper anaesthesia. As more surgeons become familiar with spinal anaesthesia, recognizing its safety, they adopt it for most operations below the diaphragm. Patients have less postoperative complica- tions from spinal and regional anaesthesia than from the other types. REGIONAL ANAESTHESIA Regional or local anaesthesia produces loss of sensibility to pain in the area or region involved, which may be small or extensive, depending upon the method used and site of injection. There is no loss of consciousness. There are four different types of regional anaesthesia: 1. Surface or topical anaesthe- sia ; 2. Infiltration anaesthesia; 3. Block anaesthesia; and 4. Spinal anaesthesia. Surface or topical anaesthesia. This type of regional anaesthesia is produced by the instillation or applica- tion of an anaesthetic agent directly on the tissue to be anaesthetized, usually the mucous membranes of the eye, nose, mouth, urethra, and anus. It is also applicable to painful skin ulcers and itching dermatitis. The four most com- monly used drugs are: Cocaine hydrochloride, (C17H21NO.HCI) ; metycaine hydrochloride, (CcHi.COOCCHsh.NCeHu.HOl) ; nupercaine hydrochloride, (aHr,N.OC4HD(2).CONH(CH2),N(C2H3)2HCl(4) ; and pontocaine hydrochloride, (C4H0NH.CcH4COO.aH4N (CHS) >. HC1). Cocaine Hydrochloride.—For instillation in the eye a 4 per cent solution is used. Two to four drops instilled in the eye at intervals of 3 to 5 minutes for a period of one-half hour will produce sufficient anaesthesia to permit operations on the eye. For internasal operations the nose is packed with pledgets of cotton soaked with a 20 per cent solution. Cocaine should never be used for local infiltration, block or spinal anaethesia as it is a very potent protoplasmic poison. Certain individuals are very susceptible to its action and grave systemic reaction may result even with topical applications. This reaction is manifested by rapid pulse, dilatation of the pupils, facial pallor, shortness of breath, anxiety and restlessness. The more serious cases may have convulsions and loss of consciousness, with the skin becoming cold and livid. Treatment for restlessness and anxiety consists in giving a barbiturate, such as pentobarbital sodium, 3 grains intravenously, and in addition institute artificial respiration. Do not give epinephrine, as the cocaine has already caused vasoconstriction. 735 736 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Metycaine Hydrochloride.—This drug can be used for topical application, local infiltration or spinal anaesthesia. It is somewhat more toxic than pro- caine, but its potency permits the use of a smaller dose, especially for spinal anaesthesia, thus making the therapeutic doses of each equal as to toxicity. For surface or topical anaesthesia a 1 per cent solution is used, and for infiltration anaesthesia 0.5 to 2 per cent. Nupercaine Hydrochloride.—In a 1 per cent solution it will anaesthetize mucous membranes, but due to its extreme potency and toxicity it should not be used repeatedly over a period of several days. Pontocaine Hydrochloride.—This drug is 10 times more toxic and 10 times more potent than procaine of which it is a derivative. For mucous membrane anaesthesia it can be used in a 1 per cent solution. It may also be used in a 1 per cent ointment, but like nupercaine, should not be used over a long period of time. Its most common use is for spinal anaesthesia. Infiltration and Block anaesthesia. Local infiltration consists of injecting the tissues at the site of the incision. All tissues to be cut must be injected. This method is applicable for minor surgical procedures but should not be used where tissues with infection are to be incised, as the injection will be painful and there is chance of spreading the infection to the lymphatics or blood stream. Block amesthesia is produced by injecting the solution around the area to be operated on. This procedure is considered superior to local infiltration and is applicable to nearly every part of the body. After local infiltration the incision can be made immediately, but with field block 5 to 15 minutes must intervene. In nerve block the injection is made around or into the nerves which supply the field of operation. Procaine hydrochloride (C13H20O2N2.HCI), different brands of which are known as Novocaine and Neocaine, is the anaesthetic of choice for infiltration and block anaesthesia. A 0.5 per cent solution is sufficiently strong for all infiltration and field block anaesthesia. For nerve block a 1 or 2 per cent solution should be used. The anaesthesia may be prolonged by the addition of epinephrine which is due to the fact that epinephrine causes a constriction of the blood vessels at the site of the injection and thus delays absorption of the anaesthetic agent. There is also less bleeding as a result of this vasoconstriction. For each 200 cc of 0.5 per cent procaine solution 16 drops or 1 cc of a 1 to 2,600 solution of epinephrine is added. With patients considered a good risk it is safe to use the following maximal amounts of procaine; 300 cc of 0.5 per cent solution; 100 cc of 1 per cent solution ; 40 cc of 2 per cent solution. Spinal anaesthesia. This is a regional nerve block accomplished by injecting the solution into the spinal canal. Another special type of anaesthesia is caudal block in which the sacral nerves are anseesthetized by an injection of an anaesthetic solution into the sacral canal. Spinal anaesthesia will permit any operation from the level of the diaphragm downward, while caudal anaesthesia limits the field of opera- tion to the structures supplied by the sacral nerves, the pelvic viscera, perineum, etc. The drugs used for spinal anaesthesia are, in the order of choice: Procaine hy- drochloride, metycaine hydrochloride, pontocaine hydrochloride, and nupercaine hydrochloride. Procaine Hyrochloride.—The dosage of procaine hydrochloride for spinal anaesthesia varies from 50 milligrams to 200 milligrams, the maximal dose. For ANAESTHESIA 737 high abdominal operations 200 milligrams are dissolved in 3 cc to 6 cc of spinal fluid and injected into the spinal canal at the third or fourth lumbar interverte- bral space. This will give an anaesthesia lasting about 1 hour. For operations on the lower abdomen 150 milligrams will suffice and 50 milligrams for short operations on the lower extremities. Metycaine Hydrochloride.—For spinal anaesthesia 75 milligrams of metycaiue hydrochloride is equivalent to 100 milligrams of procaine hydrochloride. It is given interspinally the same as procaine with approximately 30 to 40 per cent longer duration of anaesthesia. Pontocaine Hydrochloride.—This agent is obtainable in ampules containing 10 milligrams in crystal form for use in spinal anaesthesia. It is also available in ampules containing 2 cc of a 1 per cent solution representing 20 milli- grams. The adult dose ranges from 5 milligrams to 20 milligrams. The usual site of injection is between the twelfth thoracic and first lumbar vertebrae. Anaesthesia lasts from 2 to 3 hours. Nupercaine Hydrochloride.—For spinal anaesthesia a 1 to 1,500 solution is used. It produces long anaesthesia and is extremely potent and toxic. General anaesthesia produces a state of unconsciousness associated with general loss of sensation, including, of course the loss of sensibility to pain. Usually the induction is by inhalation, but may be by intravenous or rectal administration of the anaesthetic agent. The principles governing the admin- istration of general anaesthetic agents have advanced remarkably during recent years. The trained anaesthetist is not satisfied with merely keeping his patient under the influence of the anaesthetic, as was formerly the practice, but endeavors to induce and maintain a light, even, surgical stage of anaesthesia during the entire operation. The various factors which influence the proper administration of the anaesthetic are discussed in more detail at the end of this section. The anaesthetist is required in many instances to assume great responsibili- ties, and should acquire a thorough knowledge of the methods of anaesthesia and how to handle patients. In this connection it should be emphasized that patients awaiting operation frequently and needlessly are alarmed by a care- less or thoughtless remark made by the attending hospital corpsman. This is especially true in the operating room during spinal anaesthesia and the early stages of general anaesthesia while the patient is still conscious. At such times his hearing is often very acute, and he is likely to hear conversation concerning his condition which might cause him needless anxiety and add to the risks of the operation. The responsibility of the anaesthetist does not terminate upon completion of the operation. He is directly responsible for the patient during his trans- portation from the operating table to his bed and until properly relieved by a competent attendant. GENERAL ANESTHESIA Inhalation anaesthesia. Inhalation anaesthesia is based upon the laws of diffusion of gases and vapors. During induction of anaesthesia the diffusion is from the lung alveolar air spaces to the blood and tissue cells, the direction of lessening partial pressure. Upon discontinuing anaesthesia the flow is reversed. The main factors governing the efficiency and rapidity of anaesthesia are the potency of the agent, and the method of administration. These two 738 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY factors are responsible for anaesthetic concentration in the alveolar air and rapidity of diffusion through the alveolar membrane to the blood, which in turn carries the anaesthetic agent to the tissue cells, especially those of the brain. It is the saturation of the brain tissues with the anaesthetic agent which causes general anaesthesia. The rapidity with which an agent is absorbed by the brain tissues decides the rapidity of anaesthesia, and likewise the rapidity Figueb 153.—Schema of inhalation anaesthesia (after Guedel). of elimination by the brain tissues determines the speed of recovery from anaes- thesia. It must be remembered that once the brain tissues become saturated sufficiently to produce anaesthesia it will take much less of the anaesthetic agent to keep the patient in this state. Stages of Inhalation Anesthesia.—The four stages of inhalation anaes- thesia are represented in Fig. 153. It also shows the relative duration of these stages which, according to Guedel, is constant with all inhalation anaesthetic agents. ANAESTHESIA 739 The time required to carry anaesthesia through all stages by various agents, is as follows: minutes Ether 10 to 30 Chloroform 4 to 12 Nitrous oxide 1 to 4 Ethylene 1 to 4 Ethyl chloride 1 to 4 Cyclopropane ya to 3 This time is average and is flexible, depending on such conditions as age, risk group, etc. First stage.—This lasts from the beginning of anaesthesia to the loss of con- sciousness. No attempt should be made to perform any operation in this stage. During this stage the respiration is normal until the approach of the second stage when it is increased. If during this stage respiration ceases it is due to the anaesthesia being forced. The patient is holding his breath, the result of laryngeal irritation. The pupils, with no preanaesthetic medication, will be dilated or normal depending upon the emotional reaction. If morphine has been given the pupils will be contracted. The eye-lid reflex is present. This reflex is elicited by raising the upper lid and upon being released it will close. Second stage,—While this stage is short in duration it is the danger stage. Death may occur from physical injury or ventricular fibrillation and cardiac failure. Avoid all unnecessary external stimulation, such as handling the patient, loud talking, clatter of instruments and utensils, and surgical prepara- tion of the field of the operation, etc. The patient should be well strapped to the table and not touched unless he attempts to fight the anaesthesia. It must also be remembered that the patient can become delirious emerging from the third stage to the second. The greatest eye-ball activity is in this stage, the extraocular muscles moving them back and forth. Third stage.—This stage is divided into four planes and is the stage of surgical anaesthesia. In the first plane of the third stage the respiration is rhythmic and full with an increase of volume. The eye-ball activity in this plane gradually diminishes and when it ceases the second plane is reached. Eccentric fixation of the eye-ball is sometimes present instead of the eye-ball activity, but as the second plane is approached the eye-ball returns to its normal position. When no preansesthetic medication has been given the pupil returns to normal. The size of the pupil varies with preansesthetic medication. The eye-lid reflex is absent. When the anaesthesia goes from the third stage to the second (patient coming out of anaesthesia), the swallowing reflex may become evident and precedes vomiting. In the second plane respiration remains the same and the pupil usually begins to dilate. In the third plane there is intercostal muscular paralysis and respiration becomes diaphragmatic. This can be detected by watching the thoracic move- ment or by placing a hand on the anterior thoracic wall. With complete intercostal paralysis there is no motion of the thorax, (lower part of third plane). Pupillary dilatation increases. In the fourth plane respiration becomes shallow and the pupils completely dilated. Cyclopropane produces very little pupillary dilatation up to the fourth stage. Fourth stage.—This is the stage of respiratory paralysis and failure and is followed by cardiac failure. 740 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Open Drop Ether Technique.—Ether is dropped upon a wire mask covered with gauze which is held a few inches over the patient’s face for a short period so as to accustom him to the odor. It is then placed over the nose and mouth and no attempt is made to further confine the vapor by wrapping the mask. Guedel has worked out a very good system governing the amount of anaes- thetic agent to be used which is as follows: “A fair guide to the dropping rate, which of course is only approximate, depends upon the size of the drops and the thickness of the gauze mask, is 12 drops the first minute 24 drops the sec- ond minute, 48 the third minute and 96 the fourth minute, doubling, each minute, the rate of the minute before. A rough guess of the percentage of ether vapor under the mask from this rate of dropping would be about one per cent the first minute; three per cent or four per cent the second minute; six per cent or seven per cent the third minute; and ten per cent or twelve per cent the fourth minute, which last figures represent approximately total satura- tion of the ordinary mask. “It has been estimated that six per cent or seven per cent ether vapor under the mask is necessary for the maintenance of anaesthesia once it is estab- lished * * *. “With the above rate of dropping of the ether the patient should pass into the second, or delirium stage of anaesthesia in about 4 minutes. The ether con- centration inspired at that time is 10 per cent or 12 per cent, which is much higher than is necessary for maintenance. However, we must hold to this high concentration until we have driven the anaesthesia down to the desired stage * * *. It is impossible to figure the course of an anaesthesia mathemat- ically, but we may estimate that complete saturation of the mask must be main- tained from the fifth to the tenth minute after anaesthesia is started in an ordi- nary adult, and probably longer than this * * *. To summarizie the rate of ether administration, we may state that during the first 15 minutes it is carried as rapidly as possible to full saturation of the mask; about 100 drops per minute. During the second 15 minutes the rate is lowered to approximately 50 drops; during the third 15 minutes 20 or 30 drops and from this time on it is carried somewhere near the last figure. Again it is necessary to state that any esti- mate of the number of drops required or the percentages that exist under the gauze mask, cannot even approach accuracy. They are stated in this manner, only as a guide.” Sbmicloseid Method.—Is the same as the open drop method except that the mask is wrapped with towels, wet or dry, to prevent loss of anaesthetic vapor and retention of some of the expired carbon dioxide. By cutting down carbon dioxide depletion of the body the acid-base equilibrium of the blood is better maintained. Also the increase of carbon dioxide causes an increase in the amount of tidal air which with the higher concentration of anaesthetic agent will produce a faster induction of anaesthesia. The standard gas-oxygen ether machines used in the Navy give a semiclosed method of anaesthesia induction. Closed Method.—This method necessitates the mask being tightly secured around the nose and mouth, thereby preventing any loss of anaesthetic agent. The accumulation of carbon dioxide is absorbed by soda-lime placed in a by- pass between the breathing bag and anaesthetic mask. This can be cut in or out so as to regulate the carbon dioxide concentration. This feature was per- fected by Waters and it allows the use of a minimal amount of agent and conserves the body heat and moisture. Special machines must be used for this method. Drugs Used for Inhalation Anesthesia.—Nitrous oxide (N20).—A color less gas with a specific gravity of 1.527. It is not inflammable, but forms an ANAESTHESIA 741 explosive mixture when combined with ether, ethylene, or oxygen. To be a good anaesthetic gas it should be not less than 95 per cent pure. To produce anaesthesia there must be a concentration of at least 80 per cent by volume. It produces no irritation to the respiratory tracts, and has about a 15 per cent potency. (See fig. 153.) Unless there is sufficient preanaesthetic sedation it will be difficult to carry the anaesthesia beyond the middle of the first plane, third stage. In attempting to obtain a deeper anaesthesia where there has been insufficient preanaesthetic medication given the oxygen content of the anaesthetic mixture is reduced. This reduction of oxygen, if continued, will produce anoxaemia and anoxia with a resulting acidosis. The closed method is em- ployed and it can be used in the presence of a flame or cautery. It is applicable to operations of short duration and where deep anaesthesia with complete muscle relaxation is not essential. Nitrous oxide should be used with caution in the presence of high blood pressure, toxic goiter, and cardio-vascular disease. A trained anaesthetist only should administer it. Ethylene (GtH*).—A colorless gas with a specific gravity of 0.8. It is inflam- mable and has a pungent odor and sweetish taste. Mixed with nitrous oxide it is highly explosive. Its potency is about 25 per cent, anaesthesia being carried to the lower border of the first plane in the third stage which is slightly more than nitrous oxide. It will permit the use of a higher percentage of oxygen to produce the same anaesthesia, hence there will be less chance of acidosis. It is administered by the semiclosed or closed carbon-dioxide-absorption method. As it is highly inflammable it should not be used in the presence of a cautery. Ethylene can be used for much the same conditions as nitrous oxide, and like the latter it does not give good muscular relaxation, although the relaxation is better than with nitrous oxide. Cyclopropane (CsHs).—A colorless, inflammable gas, having a specific gravity of 1.46. It is supplied in cylinders and like nitrous oxide and ethylene is admin- istered by the closed method. Its absorption and elimination by the body tissues is rapid, thus producing a rapid induction and recovery from anaes- thesia. It is nonirritating to the respiratory tract and unlike the other inhalation anaesthetic agents it does not stimulate respiratory function. Cyclo- propane has a 100 per cent potency and when administered produces similar physical signs to those of ether in the various stages of anaesthesia. There are not, however, the irritating effects that are present with ether in the first and second stages. It must be remembered that with cyclopropane there is but little pupillary dilatation. The depth of anaesthesia is governed by the depth of respiration. Ether (C2H5.O.C2H5).—A transparent, colorless, inflammable liquid which vola- tilizes at room temperature. Ether vapor is 2.6 times heavier than air and when mixed with oxygen, nitrous oxide or air it is explosive and inflammable. When ether contacts the skin and is covered with a towel, thus preventing evaporation, it will cause a burn. If dropped in the eye, it will produce conjunctivitis. It has a 100 per cent potency and can be given by the open, semiclosed, or closed method. Chloroform (CHC13).—A colorless liquid with a pleasant odor, the vapor being 4.1 times heavier than air. It is not explosive, and has an anaesthetic potency of 100 per cent. As it is highly toxic to the liver and the cardio- vascular and nervous systems, and produces deep anaesthesia rapidly, it is con- sidered an unsatisfactory anaesthetic agent. It is not inflammable but its heated vapor burns with a green flame, and care must be taken not to vaporize it in the presence of a naked flame because of the production of noxious gases. 742 HANDBOOK OF THE HOSPITAL CORPS, XI. S. NAVY Ethyl chloride (CH3.CH2CI).—A colorless, inflammable liquid, the vapor being 2.2 times heavier than air. When sprayed on the skin it will freeze the superficial tissues, giving local anaesthesia. It can also be used for inhalation anaesthesia, but because of its being so volatile it is hard to maintain the anaesthetic levels. It is not recommended for inhalation anaesthesia. Divinyl oxide (CEL : CHOCH : CH2).—Known also as divinyl ether, vinyl ether, and vinethene. A colorless and inflammable liquid; it is given by the drop method. Induction and recovery are rapid, the absorption and elimination rate being twice that for ether. Physical signs of anaesthesia are practically the same as for ether. It is not recommended for long operative procedures. Further investigation must be made with respect to the value of divinyl oxide as an anaesthetic agent. With the exception of nitrous oxide and chloroform these drugs are all inflam- mable and, with the exception of chloroform and ethyl chloride, all are explosive. Therefore great care must be taken to avoid using those that are inflammable or explosive, or are both, near an open flame such as is found in a lighted gas jet, lamp, burning candle, or stove, or in the vicinity of a hot cautery or elec- tric spark. Carelessness in this respect has been the cause of many explosions and burning with fatal results. Electric sparks are the most common cause of explosions in anaesthesia, static sparks occurring within the anaesthetic appara- tus or between the patient’s face and the mask most frequently causing fatal explosions. Administration of the Anaesthetic in Inhalation Anaesthesia.—The choice of the anaesthetic to be used is left entirely to the medical officer in charge of the case, and is governed by the condition of the patient, the type of operation, the climatic conditions, and the type of agent available. The hospital corpsman is particularly interested in the last two conditions. In very hot climates, as in the tropics, it is frequently next to impossible to induct general anaesthesia with ether, as it is so volatile that evaporation occurs almost immediately upon release from its container. Under such con- ditions it may be necessary to use chloroform. As nitrous oxide and ethyl chloride usually are not available in sufficient quantities outside of hospi- tals, dependence must be placed upon ether and chloroform. It is therefore essential that the hospital corpsman become thoroughly familiar with the administration of these two ansesthetic agents, especially the former. Insufficient oxygenation of the blood is the cause of most of the difficulties in securing a quiet, peaceful, satisfactory anaesthesia, and of a large percentage of fatalities in connection with the use of anaesthetics. The first important object, therefore, is to maintain a clear air passage in the patient. The anaesthetist should familiarize himself with the signs of obstructed breathing and should be able to recognize and overcome these obstructions as they occur. The most common causes of obstruction of the air passages are partial obstruction of the nasal passages, frequently found in otherwise normal individuals; the presence of mucus or vomitus in the mouth, pharynx, and naso-pharynx; firm closure of the jaws in the early stage of anaesthesia (patients with no teeth are prone to press their upper and lower gums together so firmly that very little or no air can enter) ; dropping of the lower jaw and “swallowing” of the tongue; position of patient with reference to mechanical pressure; spasm of the laryngeal muscles. The only sure practice to follow in observing the patient’s breathing is to hear or feel every respiration. As the patient’s respiratory efforts continue for some time even though the air passages are obstructed, it is not enough that the ANESTHESIA 743 anaesthetist should only see the chest and abdominal movements; he must be certain that respiration actually is taking place. Mucus or vomitus should be removed with a gauze sponge held in forceps. Dropping of the jaw and “swallowing” of the tongue should be overcome by light, even pressure under the jaw. In this connection it may be stated that long continued pressure over a small area of the jawbone may cause considerable soreness and tenderness for several days. It is occasionally necessary to hold the tongue forward by means of tongue forceps, although this procedure should be avoided if possible. Turning the patient’s head to one side allows the drainage of mucus and other secretions and frequently prevents the backward drop of the tongue and jaw. Laryngeal spasm usually is due to reflex action; a most frequent cause is too strong anaesthetic vapor. Withholding of the anaesthetic frequently will over- come the spasm. Impending vomiting with its resulting laryngeal spasm may be prevented by deepening the anaesthesia. The question which naturally arises in each and every case is “How far is the patient under the influence of the anaesthetic?” It is essential that the anaesthetist know the exact degree of narcosis present at any and every given moment of anaesthesia. The requirements of the operation decide the depth of anaesthesia desired in each case. Constant practice in administering anaes- thetics is necessary to obtain a knowledge of the finer details concerning general anaesthesia. Induction of Ether Anesthesia.—The open-drop technique of administering ether for general anaesthesia is considered the best as the amount of mucus secreted is generally much less, the tendency to coughing and labored breath- ing is decreased, the patient’s color is better, and the pulse rate and blood pres- sure are well maintained. Most of the effects of deficient oxygenation of the blood do not occur, as this method permits the admixture of an adequate supply of oxygen from the air. When the patient is in as comfortable a position as possible the face should be anointed with a bland ointment and the eyes covered with a layer of gauze. The mouth and nose then are covered either with one of several types of gauze mask or with three or four strips of gauze. It is best to allow the patient to breathe several times with the gauze in position in order that the patient may become accustomed to its presence and also to determine whether or not the thickness of the gauze is too great to permit free and easy respiration. Before beginning the administration of the anaesthetic, which to some patients may be very disagreeable, it is frequently desirable to drop a few drops of oil of bitter orange peel on the gauze. This is then followed by the ether, which should be administered drop by drop, very slowly at first, then gradually in- creasing the amount until the patient can take the strongest vapor. The ether should be dropped over an area involving the mouth and nares. The patient should never be hurried and should never be advised to breathe deeply, as a feeling of suffocation will ensue and the patient is also likely to struggle. During the administration of the anaesthetic the anaesthetist should talk con- stantly to his patient in order to maintain the latter’s confidence. In other words, the anaesthetist should talk his patient to sleep. By this method under ordinary conditions the patient can be brought under the influence of ether in from four to six minutes. The four stages of inhalation anaesthesia with ether will next be described, omitting reference to the four planes of the third stage. 1. In the stage of analgesia, or light anaesthesia, occurs the primary decrease of consciousness 744 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY accompanied by a feeling of asphyxia and ringing in the ears. Respiration is accelerated; the blood pressure is increased slightly; the pulse becomes full and bounding; and the color of the skin becomes heightened. Concentrated vapor in this stage will cause coughing, holding of the breath, swallowing, spasm of the glottis, muscular rigidity, turning of head from side to side and slight dilatation of the pupils. 2. In the stage of delirium, or excitement, the controlling centers in the cerebrum are depressed and there is incoordination of movements and speech, which may amount to violent struggling and shout- ing. Memory, volition, and intelligence are interfered with; consciousness is partially or wholly lost; marked rigidity of muscles supervenes; the pupils are dilated and mobile; secretions of the respiratory tract are increased markedly; the face is very flushed; perspiration is evident and the breathing may be irregu- lar. As the patient passes from this stage to the third stage, vomiting is not infrequent. Patients addicted to the use of alcoholic liquors frequently require a rather forced administration of the anaesthetic during this stage. In the stage of surgical anaesthesia the cerebrum and spinal cord are paralyzed, sensa- tion to pain is lost, and there is complete unconsciousness and relaxation. The respirations are deep, regular, and generally audible. A soft stertor may be considered normal. A strong stertor indicates obstruction of the air passage which requires immediate attention. The color of the face, ears, and lips is normal; the pupil is usually normal or contracted, but reacts to light; and the eyeball is eccentric or oscillatory. If the eyeball is stationary on center with pupil dilated, the patient is receiving too much ether, the administration of which should be discontinued at once. The lid reflex is weakly active; coughing and phonation are absent; and the heart action is accelerated. As anaesthesia progresses the face may become more flushed than normal. From the third stage the patient may change in the direction of consciousness or of deepening narcosis, the fourth stage. Returning consciousness is indicated by the following signs: Respiration regular, not full, but quiet; pallor of face; moderate dilatation of the pupils with light reflex ; increased activity of lid reflex ; swallowing movements ; return of phonation. 4. The stage of respiratory paraly- sis, or dangerous stage, is the stage of overdose of the anaesthetic. The medulla oblongata becomes paralyzed and asphyxia and weakened circulation follow. Death occurs in this stage from paralysis of the respiratory center in the medulla. The signs of the fourth stage are weak, shallow respiration, cyanosis, soft feeble irregular pulse, dilatation of pupils with no reaction to light, absence of lid reflex, central fixation of eyeballs, separation of eyelids, and fall of blood pressure. Treatment of Emergencies.—While every effort should be made to prevent the occurrence of emergencies, it is nevertheless true that, even in the hand of the most expert anaesthetists, various crises may occur which require immediate treatment. These emergencies or crises may be grouped under two headings, those due to respiratory failure and those due to circulatory failure. Reference already has been made to certain causes of respiratory obstruction and the indicated remedial measures have been discussed. The main effort in cases of respiratory failure should be directed toward clearance of the air passage and maintenance of the act of respiration. If the latter be not voluntary, artificial respiration is indicated. Regular pressure on the chest, drawing the tongue for- ward and lowering the head usually will restore normal breathing. If this pro- cedure fails, it may be necessary to perform artificial respiration in accordance with the Sylvester method. Large amounts of fluid in the abdominal and pleural cavities may be the cause of respiratory embarrassment, and measures directed toward at least partial removal of these causes should be instituted. ANESTHESIA 745 The loss of the pupillary and corneal lid reflexes, associated with feeble respiration and, increasing cyanosis, indicates paralysis of the respiratory center in the medulla. A hypodermic injection of atropine sulfate should be given immediately and artificial respiration instituted and continued until normal breathing is resumed. Anaemia of the brain, due to extensive haem- orrhage or to chloroform, is counteracted by lowering the head and raising the lower limbs if necessary. Circulatory failure recognized by a running, feeble, or irregular pulse, in- creasing pallor, and feeble respirations must be overcome by stimulation of respiration as indicated above and by the administration hypodermically of cardiac stimulants (caffeine, epinephrine, etc.). Any change in the general condition of the patient should be communicated immediately to the operating surgeon. The latter depends upon the anaes- thetist to inform him concerning the progress of the anaesthesia, and the anaesthetist should not hesitate to institute whatever measures are indicated to promote a successful anaesthesia. Intravenous anaesthesia. The two anaesthetic agents commonly used in intravenous anaesthesia are: Evipal soluble, or sodium cyclural, (Sodium N-Methyl-cyclohexenyl-methylma- lonylurea) ; and Pentothal sodium (Sodium ethyl (1-methyl butyl) thiobarbitu- rate). Both are derivatives of barbituric acid and are obtainable in ampules containing 15 grains (1 Gm.) each. The method of administration and the effects of both are the same, so the technique described herewith will apply to either. Pentothal sodium is the more potent of the two, requiring less dosage and giving more relaxation. Technique of Administration.—The contents of one ampule (1 Gm.) is dissolved, in 20 cc of triple-distilled sterile water making a 5 per cent solution. Each cubic centimeter of this solution contains % grain of the agent. This is drawn up into a 20 cc syringe to which is attached a 20 gauge needle. A vein is selected, preferably in the arm, the skin is prepared and the arm draped. The vein is punctured with the needle and the solution injected slowly. At the time the injection is started the patient is told to count slowly and usually can only count to seven or ten before becoming anaes- thetized. By this time (5 to 15 seconds) from 2 to 4 cc’s have been injected. This will give from 15 to 30 minutes anaesthesia. To give further anaesthesia an additional 1 or 2 cc’s of the solution is injected after the patient shows signs of recovering from first injection. Recovery is indicated by movements, deepening respiration, and increased muscle tone. The two things that must be maintained are unobstructed air passage and sufficient depth of respira- tion. Four cc’s of the 5 per cent solution given rapidly can stop respiration, and 2 cc in the aged will produce the same bad effect. Preliminary medication is the same for this type of anaesthesia as for others except that where the surgical procedure will last but a few minutes, the preanaesthetic medication can be omitted. Rectal anaesthesia. This type of anaesthesia, also known as colonic, is produced by the instillation of a drug into the rectum. The two commonly used drugs are avertin (tribrom- ethanol (CBrs.CHaOH) dissolved in amylene hydrate) and ether and oil. Avebttn gives sedation simulating sleep but is not analgesic; therefore pain stimuli will arouse the patient. It depresses respiration and circulation but less postoperative medication is needed, and is safe for use in conjunction with other anaesthetic agents. Avertin is a white crystalline substance and 746 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY must not be exposed to sunlight or alcohol. Elimination is by the liver and to some extent by the kidneys. Anaesthesia with this agent will last from 1 to 4 hours, averaging iy2 hours. Following the period of anaesthesia the patient usually has a period of peaceful sleep lasting from 3 to 6 hours. It should be used with caution where there is evidence of disease of the kidney, liver or rectum. The dosage is governed by the patient’s weight and age and the solution prepared in accordance with a special table. It should be given only under the supervision of a medical officer. Preparation of patient.—Give a cleansing enema, not soap-suds, the day before operation and a sedative the night before. Repeat the enema on the morning of operation. Preanaesthetic medication should be given 1 hour before operation. Following the operation any anaesthetic remaining in the rectum should be siphoned off and the rectum cleansed with 1 quart of warm water. The anaesthetic tray should contain the following articles; 1. Large catheter. 2. Rubber tubing with connection for catheter. 3. Funnel to fit into tubing. 4. Special mixing flask and cork. 5. Large pan to hold hot water and flask. 6. Distilled water. 7. Thermometer (centigrade). 8. Graduate (cc). 9. Bottle of Congo red with dropper. 10. Lubricant. 11. Draw sheet (1) ; Tow'els (4). In Oil-ether Anesthesia a combination of ether and olive oil is given rec- tally by means of rectal tube or large catheter and funnel. The systemic effect is the same as when ether is administered by inhalation. The mixture used consists of 6 fluidounces of ether and 2 fluidounces of olive oil which makes a 75 per cent mixture. The dose of this mixture is on the basis of 1 fluidounce to each 20 pounds of body weight, and a man weighing 140 pounds would there- fore require 7 fluidounces. The patient is prepared the same as for avertin anaesthesia, except that the skin over the sacrum and perianal region must be protected with petrolatum for the oil-ether mixture is very irritating to the skin. The genitalia and inner aspect of the thighs must he well draped. At the finish of the operation any anaesthetic remaining in the rectum should be siphoned off and measured. Cleanse the rectum with 1 quart of warm water, and then instill about 100 cc of olive oil and allow it to remain. The patient should have close supervision following both avertin and oil-ether anaesthesia, using the same precautions as are taken for ether inhalation anaesthesia. The anaesthetic tray should contain the following articles: 1. Large catheter or rectal tube. 2. Funnel to fit catheter or rectal tube. 3. Bottle or container with tight-fitting top for mixing oil and ether. 4. Graduate. 5. Petrolatum. 6. Draw sheet. 7. Towels. 8. Clamp for rectal tube. ANESTHESIA 747 PREAIOESTHETIC MEDICATION Preansesthetic medication is important, as it allays the patient’s fear and anxiety, thus giving him more nearly normal pulse, respiration and blood pressure, with a quiet induction, and thereby requiring less anaesthetic agent. The night before operation a mild sedative, such as codeine or a barbiturate should be given to induce sleep. On the day of operation further preansesthetic medication with opium de- rivatives, solanaceous alkaloids, barbituric acid derivatives, etc. should be given. Opium derivatives. Morphine, the most commonly used of these derivatives, is an analgesic in small doses and a respiratory depressant in large doses. It should be given 1 to 1% hours prior to operation, as there may be a mild stimulation during the first half-hour, and the greatest respiratory depression during the second half hour. The dosage used is Vs to M grain. Solanaceous alkaloids. Atropine lessens the secretions of the respiratory tract and stimulates metabo- lism. Because of the metabolic stimulation it should not be given to toxic goiter cases. It is usually given combined with morphine in which form the usual dose is morphine M grain and atropine Mso grain. Scopolamine is given for its sedative action thereby inhibiting the emotional activity. It is often given in combination with morphine when there is obtained both sedative and analgesic action, the ordinary dosage in this form being morphine M grain and scopolamine Moo grain. Barbituric acid derivatives. Of the many barbiturates available the most commonly used are barbital, amytal, phenobarbital and pentobarbital in the form of their more soluble sodium salts. They all act similarly as soporifics, affecting the intellectual cen- ters with practically no analgesic action. They are synergetic in action with morphine, hence when used in combination with morphine there will be obtained cerebral sedation and analgesia. Barbital and phenobarbital are eliminated mostly by the kidneys, while amytal and pentobarbital are detoxified by the liver. Hence, with pathology in the kidneys, amytal and pentobarbital should be chosen. Likewise, with liver damage, barbital and phenobarbital are preferable. Tribromethanol, or Avertin, is sometimes used as a preansesthetic medica- tion being given per rectum in doses of 60 mgm. per kilogram of body weight. References The Operating Room—Instruction for nurses and assistants.—St. Mary’s Hospital, Rochester, Minn. Inhalation Anaesthesia—A fundamental guide.—A. E. Guedel, M. D. Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. 154294°—39 48 CHAPTER XI Page Section 1. Administration and General Clerical Procedures 749 Section 2. Hospital Supplies and Property Accountability 774 Section 3. Commissary Supervision 804 Section 4. Deaths and Medico-Legal Matters 833 Section 1.—ADMINISTRATION AND GENERAL CLERICAL PROCEDURES Upon the officers and enlisted men of the Hospital Corps the Medical Depart- ment of the Navy depends largely for the supervision and the performance of the clerical work required wherever there is a representative of the Medical Department on duty. In the lower ratings the primary duty of hospital corpsmen concerns the care of the sick and the injured. As they advance in rating they necessarily become more familiar with the administrative and clerical duties in the Medi- cal Department, and when assigned to such duties must assume responsibility not only for the accuracy of the work performed but also for so organizing and supervising the clerical force that a maximum of efficiency will be obtained. To satisfactorily perform these duties, hospital corpsmen must: 1. Be conversant with the Navy as regards its organization and personnel, its history, and the laws and regulations governing the Naval Establishment; 2. Be thoroughly familiar with the history and organization of the Medical Department, the laws and regulations governing its duties, the sources and application of monies under its control, and the relationship of the Medical Department to the Naval Establishment; 3. Have a full knowledge of the duties of the Medical Department ashore in naval hospitals and at other shore stations, and afloat on the various types of vessels composing the fleets; and 4. Understand office management and the Navy Regulations and bureau manuals governing the performance of clerical and administrative duties. In this section much information that could well be included is omitted on account of lack of space and because it can be found in official publica- tions that are easily accessible. For these reasons the information given here is more or less general in scope and must be supplemented by reference to other publications for detailed and specific information not found here. THE NAVY DEPARTMENT, ITS BUREAUS AND OFFICES Section 415 of the Revised Statutes of the United States provides that there shall be at the seat of government an executive department, to be known as the Department of the Navy, and a Secretary of the Navy, who shall be the head thereof. The Navy Department is charged with the general control and administration of the Navy of the United States. In section 2 of Article II of the Constitution of the United States ,of America it is provided that the President of the United States shall be the Commander in Chief of the Navy of the United States. 749 750 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The Secretary of the Navy, a civil officer, is appointed by the President, by and with the advice and consent of the Senate of the United States, and because he is the head of an executive department is a member of the Presi- dent’s Cabinet. He performs such duties as the President may assign to him or are required by law and has the general superintendence of construction, manning, armament, equipment, and employment of vessels of war. The Secretary’s deputy is the Assistant Secretary of the Navy, a civil officer, whose appointment is authorized by law and who performs such duties as may be prescribed by the Secretary of the Navy or are required by law. In the absence of the Secretary of the Navy his duties are performed by the Assistant Secretary of the Navy. In the temporary absence of the Secretary and the Assistant Secretary of the Navy, the Chief of Naval Operations is, by law, next in succession to act as Secretary of the Navy. In the absence of all three of those just named the duties of the Secretary of the Navy temporarily devolve upon line officers of the Navy in the following order of succession: Chief of the Bureau of Navigation, Chief of the Bureau of Ordnance, Chief of the Bureau of Engi- neering, Chief of the Bureau of Aeronautics, and the Judge Advocate General of the Navy. For administrative purposes the Navy Department is divided into the Office of Naval Operations and eight bureaus, each charged with certain specific duties and in charge of an officer of the Navy appointed by the President, by and with the advice and consent of the Senate. These officers are appointed for 4 years and during their term of office have the rank of rear admiral except in the case of the Chief of Naval Operations who has the rank of admiral. In addition to the foregoing there are the Judge Advocate General of the Navy and the Major General Commandant of the Marine Corps. The Judge Advocate General is an officer of the Navy or the Marine Corps, appointed by the President for 4 years, by and with the advice and consent of the Senate, and while so serving has the rank of rear admiral in the Navy or of major general in the Marine Corps, as the case may be. The Major General Commandant of the Marine Corps is an officer of the Marine Corps appointed by the President for 4 years, by and with the advice and consent of the Senate, and while so serving has the rank of major general in the Marine Corps. Following is a list of the eight bureaus of the Navy Department and the titles of the officers in charge of them: Yards and Docks Chief of the Bureau. Navigation Chief of the Bureau. Ordnance Chief of the Bureau. Construction and Repair Chief Constructor and Chief of the Bureau. Engineering Engineer in Chief and Chief of the Bureau. Supplies and Accounts Paymaster General and Chief of the Bureau. Medicine and Surgery Surgeon General and Chief of the Bureau. Aeronautics Chief of the Bureau. The business of the Department of the Navy not specifically assigned by law is distributed among the bureaus and offices by the Secretary in such manner as he judges to be expedient and proper. The various duties per- formed under this distribution are, briefly, as follows: ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 751 Office of the Chief of Naval Operations. Operations of the fleet and the preparation and readiness of plans for its use in war; direction of the Office of Naval Intelligence and the Division of Fleet Training; operation of the Communication Service, of naval districts, of Naval Reserve vessels, and of mines and mining; the operations of the Marine Corps, except when operating with the Army or on other detached duty by order of the President; the operations of Coast Guard vessels when operating with the Navy; the direction of all strategic and tactical matters, organization of the fleet, maneuvers, gunnery exercises, drills and exercises, and the train- ing of the fleet for war; and the preparation, revision, and record of regula- tions for the government of the Navy, general orders, tactical Instructions, drill books (except those issued for the individual instruction of officers and enlisted men), signal codes, and cipher codes. Bureau of Yards and Docks. The design, construction, alteration, and inspection of the public works and public utilities of the shore establishments of the Navy and (with certain exceptions) their repair and upkeep and administrative supervision of opera- tion ; the acquisition and disposition of real-estate and the custody of real property no longer needed for the use assigned, as provided in articles 426 and 427, U. S. Navy Regulations. Bureau of Navigation. The procurement, education, training, discipline, and distribution of officers and enlisted men of the Navy, Naval Reserve, and the Reserve Officers’ Train- ing Corps, except the professional education of officers, nurses, and enlisted men of the Medical Department; the supply, maintenance, and repair of ships’ navigational outfits, including instruments; ocean and lake surveys and the collection of foreign surveys; the publication and supply of charts, sailing directions, and nautical works, and the collection and dissemination of all nautical, hydrographic, and meteorological information to ships and aircraft; the upkeep, operation, and repair (with certain exceptions) of the Naval Academy, Postgraduate School, Naval War College, training schools for en- listed men, training stations, Naval Home, Naval Observatory, and Hydro- graphic Office; the direction of receiving ships and stations; the issue, recording, and enforcement of orders of the Secretary of the Navy to officers of the Navy and of the Naval Reserve; the keeping of the records of service of officers and enlisted men; the preparation, revision, and enforcement of regulations governing uniforms; and naval discipline, rewards, and punishments. Bureau of Ordnance. The design, manufacture, procurement, maintenance, issue, and efficiency of all offensive and defensive arms and armament, and, unless otherwise excepted, optical and other devices and material for the control of guns, torpedoes, and bombs; the upkeep, operation, and repair (with certain ex- ceptions) of naval gun factories, ordnance plants, torpedo stations, proving grounds, powder factories, ammunition depots, magazines on shore, and mine depots. Bureau of Construction and Repair. The general design, structural strength, stability, and seaworthiness of all ships of the Navy, except airships; the designing, building, fitting out, and repairing of hulls of vessels; preparation of plans and data showing designs 752 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of new vessels; provision of facilities and arrangements for salvage of ves- sels; the drydocking of vessels and the operating and cleaning of drydocks and marine railways; the design, development and procurement of materials and appliances for gas defense; diving gear and experimental diving units, and respiratory protective devices; paravanes and mine-sweeping gear. Bureau of Engineering. The design, construction, installation, and maintenance of all propelling machinery, together with its auxiliaries, and, unless otherwise excepted, exterior and interior communication systems, electric wiring and cable, and auxiliary machinery; the design, manufacture, installation, and maintenance of all radio and sound equipage; the upkeep, operation, and repair (with certain exceptions) of the Engineering Experiment Station, Naval Research Labora- tory, Naval Boiler Laboratory, and Material Laboratory (jointly with the Bureau of Construction and Repair) ; preparation of specifications for fuel. Bureau of Supplies and Accounts. The procurement, purchase, custody, shipment, warehousing, and sale of all supplies, fuel, and other property of the Navy (unless otherwise provided for and excepting supplies for the Marine Corps) ; the supply and disbursement of funds and the payment for articles and services procured for the Navy; the upkeep and operation of the Naval Clothing Factory and coffee-roasting plants; administrative supervision over fuel plants and commissary activities; authorization of transportation of Navy property and household effects of Navy personnel. Bureau of Medicine and Surgery. “The Bureau of Medicine and Surgery, under the direction of the Secretary of the Navy, is charged with and responsible for the maintenance of the health of the Navy, for the care of the sick and injured, for the custody and preserva- tion of the records, accounts, and properties under its cognizance and pertain- ing to its duties, and for the professional education and training of officers, nurses, and enlisted men of the Medical Department of the Navy.” (Art. 457 (1), N. R.) “It is charged with the upkeep and operation of all naval hospitals, medical supply depots, medical laboratories, the Naval Medical School and of all tech- nical schools established for the education or training of members of the Med- ical Corps, Dental Corps, Nurse Corps, and Hospital Corps, and with their repairs, except as excluded in article 484.” (Art. 457 (2), N. R.) “The Bureau of Medicine and Surgery shall provide for inspection of the sanitary condition of the Navy, shall recommend with respect to all questions connected with hygiene and sanitation affecting the service, and, to this end, shall have opportunity for necessary inspection; it shall advise with other bureaus and offices in reference to the sanitary features of ships under con- struction and in commission, regarding berthing, ventilation, and location of quarters for the care and treatment of the sick and injured; of the provisions for the care of wounded in battle; and, in the case of shore stations, with regard to health conditions depending on location, the hygienic construction and care of public buildings, especially of barracks and other habitations, such as camps. It shall also advise concerning matters pertaining to clothing and food, to water supplies used for drinking, cooking, and bathing purposes, and to drainage and disposal of wastes, so far as these affect the health of the Navy. It shall safeguard the personnel by the employment of the best methods of hygiene and sanitation, both afloat and ashore, with a view to maintaining ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 753 the highest possible percentage of the personnel ready for service at all times, and shall adopt for use all such devices or procedures as may be developed in the sciences of medicine and surgery as will in any way tend to an increase in military efficiency.” (Art. 458 (1), N. R.) “It shall be the duty of the Bureau of Medicine and Surgery to provide for the physical examination of officers, nurses, and enlisted men, with a view to the selection or retention of those only whose physical condition is such as to maintain or improve the military efficiency of the service if admitted or retained therein; and it shall pass upon the competency, from a professional standpoint, of all men of the Hospital Corps for enlistment, enrollment, and promotion by means of examinations conducted under its supervision or by such forms as it may prescribe.” (Art. 458 (2), N. R.) “The Bureau of Medicine and Surgery shall recommend to the Bureau of Navigation the complement of Medical Department personnel for hospitals and hospital ships, and shall recommend and have information as to the assignment and duties of medical officers, dental officers, and hospital corps- men. It shall be charged with the administration of the Nurse Corps, and shall have power to appoint and remove all nurses, subject to the approval of the Secretary of the Navy.” (Art. 458 (3), N. R.) “It shall require for and have control of the preparation, inspection, recep- tion, storage, care, custody, transfer, and issue of all supplies of every kind used in the Medical Department for its own purposes; and shall have charge of the civilian force employed at naval hospitals, medical supply depots, medical laboratories, the Naval Medical School, and at all technical schools for the education or training of Medical Department personnel.” (Art. 458 (4), N. R.) “It shall approve the design of hospital ships insofar as relates to their efficiency for the care of the sick and wounded, and shall provide for the organization and administration of the Medical Department of such vessels.” (Art. 458 (5), N. R.) “The arrangements for care, transportation, and burial of the dead shall be under the jurisdiction and control of the Bureau of Medicine and Surgery, except as otherwise provided in article 1841.” (Art. 458 ( 6), N. R.) Bureau of Aeronautics. The design, construction, fitting out, testing, repair, and alteration of naval and Marine Corps aircraft and (with certain exceptions) instruments, equip- ment, and accessories pertaining thereto; the upkeep, operation, and repair (with certain exceptions) of all aeronautics shore establishments of the Navy and Marine Corps, exclusive of aircraft operations. The Judge Advocate General of the Navy. Shall have cognizance of all matters of law arising in the Navy Department; revise and report upon the legal features of and have recorded the proceedings of all courts-martial, courts of inquiry, boards* of investigation and inquest, and boards for the examination of officers for retirement and promotion in the naval service; prepare charges and specifications for courts-martial, and the necessary orders convening courts-martial, courts of inquiry, and various exam- ining boards when ordered by the Secretary of the Navy; prepare courts-martial orders promulgating final actions and other legal information; conduct all official correspondence relating to such courts and boards; examine and report upon all questions relating to rank and precedence, promotions and retirements, and the validity of the proceedings in court-martial cases, all matters relating to the supervision and control of naval prisons and prisoners, including prisoners of war; removal of the mark of desertion, correction of records of service of 754 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY naval personnel; certification of discharge in true name; pardons; interpretation of statutes; references to the General Accounting Office; proceedings in civil courts by or against the Government or its officers; preparation of advertise- ments, proposals, and contracts; insurance; patents; the sufficiency of official contracts, and other bonds and guarantees; claims by or against the Govern- ment; conduct correspondence respecting the foregoing, including preparation for submission to the Attorney General of all questions directed by the Secretary of the Navy to be so submitted; examine and report upon all Congressional bills and resolutions referred to the Navy Department; draft all proposed legislation arising in the Navy Department; examine and report on questions of international law; search titles, purchase, sale, transfer, and other questions affecting lands and buildings pertaining to the Navy; and care for and preserve all muniments of title to land acquired for naval uses. The Major General Commandant of the Marine Corps. The procurement, discharge, education, training, discipline, and distribution of officers and enlisted personnel of the Marine Corps, including the Marine Corps Reserve, and the administration and general efficiency of the Marine Corps and of the Marine Corps Reserve; the upkeep, operation, and repair (with certain exceptions) of marine barracks and marine posts. THE NAVAL FORCES AND N£VAL STATIONS Primarily, the Navy is the naval forces of the United States composed of the combatant forces of vessels, aircraft, and troops operating under naval authority together with such additional vessels, district craft, aircraft, or other units as may be assigned thereto for training, utilitarian, or other purposes. The combatant forces are organized into fleets, forces, type organizations, flotillas, aircraft wings, aircraft groups, squadrons, and divisions. The vessels of the Navy are classified as battleships, cruisers, aircraft carriers, destroyers, mine layers, submarines, patrol vessels, and auxiliaries consisting of destroyer, submarine, aircraft, and seaplane tenders; repair, store, ammunition, and cargo ships; oilers; transports; mine sweepers; submarine rescue vessels; hospital ships; and tugs. Although afloat, the vessels of the naval forces must place great dependence on shore stations for many repairs, for supplies and equipment, and for personnel so that the maximum of efficiency may be maintained. As a direct result of this dependence the Navy Department has under its control a number of naval stations both within and without the continental limits of the United States. The United States and its possessions, with the exception of Guam, Amer- ican Samoa, Puerto Rico, and the naval station at Guantanamo, are divided into naval districts within which are located naval bases, navy yards, and naval stations. The following definitions from Navy Regulations clearly state the composi- tion and object of naval bases and shore stations: “A naval base is, generically, a center from which men-of-war can operate and be maintained, and may be of a permanent or temporary character, de- pending upon whether its constructed naval accommodations are of a fixed or transient nature.” (Art. 2050 (a), N. R.) “Naval bases are divided geographically into two classes, home bases and outlying bases, and these are themselves divided by their facilities into main bases, subsidiary bases, and bases for particular types of naval craft. ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 755 (Destroyer bases, submarine bases, aviation bases, etc.).” (Art. 2050 (b), N. R.) “A main home base is one within the continental territory of the country, from which the fleet can operate at all times and which is designated to maintain the fleet in all respects, both in peace and war.” (Art. 2050 (c) N. R.) “A main outlying base is one without the continental limits of the country, having as many of the attributes of a main home base as practicable, and designed to be a strong point of support for the fleet and from which it can be maintained for limited periods in war.” (Art 2050 (d), N. R.) “A subsidiary base (home or outlying) is one that contains some of the fixed elements of the main base and which, while not capable of supporting and maintaining the whole fleet, may so care for portions of it.” (Art. 2050 (e), N. R.) “A destroyer, submarine, aviation, or other base for particular types of naval craft is one from which the type in question can operate and be main- tained. It may or may not form part of a main or subsidiary base.” (Art. 2050 (f), N. R.) “An outlying base of a temporary character used in war for the fleet or portions of it is termed an advanced base.” (Art. 2050 (g), N. R.) “The characters, composition, and strength of naval bases will depend upon the necessities of service, at all times.” (Art. 2050 (h), N. R.) “A naval station is the location of a particular form of naval activity, and may or may not form part of a naval base.” (Art. 2050 (i), N. R.) “A naval depot is the location where naval personnel or material is stored and delivered, and may or may not form a part of a naval base.” (Art 2050 (j), N. R.) Navy yards are shore establishments, largely industrial in character, that are principally concerned with the repair, alteration, dry docking, and overhaul of naval vessels. Some are equipped for the construction of naval vessels and others for special kinds of work. The following definitions of certain naval terms often used are from U. S. Navy Regulations: “Strategy applies to the distribution of naval forces, their armament and supplies in preparation for war or in the prosecution of war. It includes logistics. It refers to naval movements and dispositions made before contact with the enemy’s forces.” (Art. 2051, N. R.) “Tactics applies to all naval movements and operations made after contact with the enemy’s forces. The term ‘contact’ is here employed in a broad sense, meaning such proximity to the enemy as affects fleet formation and renders a battle imminent.” (Art. 2052, N. R.) “Naval policy.—Everything that includes the fixed condition of preparation for war; that is, the strength, character, and composition of the Navy, forti- fication of ports and bases, etc. (This wrill be based upon our political rela- tions and the probability of war with different powers. It will also be influ- enced by the conclusions of a comprehensive study of the political relations between other powers throughout the world and their influence upon coali- tions and alliances.)” (Art. 2053, N. R.) From before the inception of the Government to August 31, 1842, the history of the medical department of the Navy is interwoven with that of other branches of the service. In 1775 the Continental Congress organized the Navy. Thus it will be seen that the Navy has existed longer than the Government and was established THE BUREAU OF MEDICINE AND SURGERY 756 HANDBOOK OF THE HOSPITAL COEPS, TJ. S. NAVY prior to the Declaration of Independence. Military control of the earliest vessels of the Navy was directly under the Continental Congress and was conducted through its naval committee. Under the present form of government the executive department known as the Department of War was created by act of Congress in 1789. This depart- ment controlled the Navy as well as the Army. By the act of Congress of April 30, 1798, another executive department, denominated the Department of the Navy, was established. But the Navy Department was not divided into bureaus and consisted only of one office, whose head then, as now, was the Secretary of the Navy. Each vessel of the Navy in those historical days carried at least one sur- geon, and some of the larger ships a surgeon and surgeon’s mate. Surgeons usually held commissions, and the surgeon’s mates received warrants. These members of the medical profession serving in the Navy seem to have had little, if any, relationship to one another (which is not surprising when one realizes that at that time there was no medical corps and no organization in the Navy Department directly responsible for the supervision of them or their work), and their rank and status was not well defined. The first attempt to regulate the medical establishment and provide a sys- tematic organization occurred in 1799, when Congress authorized the following officers in the medical establishment of the United States: “A physician general who shall be charged with the superintendence and direction of all military hospitals, and generally of all medical and chirurgical practice or service con- cerning the Army or Navy of the United States, and of all persons who shall be employed in and about the same, in camps, garrisons, and hospitals; an apothe- cary general, and one or more deputies, who shall be charged with the safe- keeping and delivery of all medicines,- stores, and whatsoever else may be necessary in relation to said practice or service.” In 1815 Congress authorized the President to appoint three naval officers as a board of commissioners for the Navy, to be attached to the Secretary’s office and, under his direction, to discharge the ministerial duties of his office. Here may be seen the first step toward the creation of the present day chiefs of bureaus. In 1832 two post captains were added to the board of commissioners for the Navy, making five members on the committee. Then came the reorganization of the Navy Department, when by the act of August 31, 1842, the board of commissioners for the Navy was abolished and five bureaus were created to conduct the business of the Navy Department. The Secretary of the Navy by this act was directed to assign the duties of the newly created bureaus in the following words: “Sec. 5. And be it further enacted, That the Secretary of the Navy shall assign and distribute among the said bureaus such of the duties of the Navy Department as he shall judge to be expedient and proper; and all the duties of the said bureaus shall be per- formed under the authority of the Secretary of the Navy, and their orders shall be considered as emanating from him and shall have full force and effect as such.” One of the bureaus created by this act, and by it responsible for conducting a part of the business of the Navy Department, was the Bureau of Medicine and Surgery, and its existence as a separate and distinct bureau in the Navy Department dates from August 31, 1842. At that time there were 60 surgeons in the Navy and the first chief of the Bureau of Medicine and Surgery was selected from them. Upon the man so selected rested the burden of planning the organization of the newly created bureau, of developing a medical corps, of coordinating the activities of the sur- ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 757 geons and surgeon’s mates, and other personnel, and formulating the necessary regulations to govern and control this branch of the Navy Department. Viewed from the standpoint of later years it must be conceded that a wise selection was made in choosing as the first Chief of the Bureau of Medicine and Surgery, Surgeon William Paul Crillon Barton. By education, training, and naval experience he was peculiarly fitted to organize and administer the new bureau, and to him must be accorded full credit for the work which he performed under adverse and trying conditions in establishing the bureau upon a firm foundation. Following is a list of the names of the chiefs of the Bureau of Medicine and Surgery and the Surgeons General, United States Navy, from 1842 to date: Chief of Bureau. (Act of August 31, 18^2.) William Paul Crillon Barton Sept. 2, 1842, to Apr. 1, 1844. Thomas Harris Apr. 1, 1844, to Sept. 30, 1853. William Whelan Oct. 1, 1853, to June 11, 1865. Phineas J. Horwitz July 1, 1865, to June 30, 1869. Chief of Bureau, with relative rank and pay of commodore and title of Surgeon General. (Act of March 3, 1871.) William Maxwell Wood July 1, 1869, to Oct. 31, 1871. Jonathan M. Foltz Nov. 1, 1871, to June 8, 1872. James C. Palmer June 10, 1872, to July 8, 1873. Joseph Beale July 9, 1873, to Feb. 2,1877. William Grier Feb. 3, 1877, to Oct. 5, 1878. J. Winthrop Taylor Oct. 28, 1878, to Aug. 19, 1879. Philip S. Wales Aug. 20, 1879, to Jan. 27, 1884. Francis M. Gunnell Apr. 1, 1884, to Apr. 1, 1888. John Mills Browne Apr. 2, 1888, to May 10, 1893. James Rufus Tryon May 11, 1893, to Sept. 7,1897. Newton L. Bates Oct. 1, 1897, to Oct. 18, 1897. Chief of Bureau, ivith the rank of rear admiral, title of Surgeon General, and pay and allowances of brigadier general in the Army. (Act of March 3, 1899.) William Knickerbocker Van Reypen Oct. 23, 1897, to Jan. 25, 1902. Presley Marion Rixey Feb. 5, 1902, to Feb. 4, 1910. Charles Francis Stokes Feb. 7, 1910, to Feb. 6, 1914. Chief of Bureau, vnth the rank of rear admiral, title of Surgeon General, and pay and allowances of major general in the Army. (Act of July 1, 1918.) William Clarence Braisted Feb. 7, 1914, to Nov. 29, 1920. Edward Rhodes Stitt Nov. 30, 1920, to Nov. 29, 1928. Charles Edward Riggs Jan. 19, 1929, to Jan. 18, 1933. Perceval Shearer Rossiter Mar. 16, 1933, to Nov. 30, 1938. Ross “T” Mclntire Dec. 1, 1938, (present incumbent). The duties of the Bureau of Medicine and Surgery, as defined by the United States Navy Regulations, articles 457 and 458, are given on pages 752 and 753. To carry out these duties, officers and enlisted men of the Medical Depart- ment of the Navy necessarily will be found wherever the activities of the Navy lead. 758 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAYY The primary duty of the medical department of the Navy is to preserve the Navy’s personnel from impairment by reason of sickness or injury, and to return men so incapacitated to active duty in the shortest period consistent with circumstances. To accomplish this object more readily, naval hospitals have been established at the geographical points where concentration of naval activities occurs and the Bureau of Medicine and Surgery is charged with their upkeep and operation under the general charge and superintendence of the Secretary of the Navy. Officers and enlisted men of the Navy and Marine Corps, afloat and ashore, in need of hospital treatment are transferred to the naval hospital most convenient to the ship or station on which they are serving at the time. To provide hospital care for the personnel of the fleets when transfer to a naval hospital is not possible, modern hospital ships are available. It is in naval hospitals that the medical department’s utility as a conserving force of the personnel of the Navy becomes most apparent, where its sphere of usefulness is best demonstrated, and where all that pertains to the sick and injured finds its fullest development. The naval hospitals controlled by the Bureau of Medicine and Surgery and at present in commission are located at: Portsmouth, N. H.; Chelsea, Mass.; Newport, R. I.; New York, N. Y.; Philadelphia, Pa.; Annapolis, Md.; Wash- ington, D. C.; Norfolk, Va.; Parris Island, S. O.; Charleston, S. O.; Pensacola, Fla.; Great Lakes, 111.; San Diego, Calif.; Mare Island, Calif.; Puget Sound, Wash.; Pearl Harbor, Hawaii; Guam; and Canacao, P. I. In addition to the above naval hospitals, at the submarine bases at New London, Conn., and Coco Solo, O. Z., at the Marine Barracks, Quantico, Va., and at the naval stations, Guantanamo Bay, Cuba, and Tutuila, Samoa, establishments commonly known as sick quartersi provide for the care of the sick and injured at these places in a manner similar to naval hospitals. The naval hospitals at Brooklyn, N. Y., and San Diego, Calif., are designated for the treatment of cases of malignant diseases. In addition to the hospitals directly under the cognizance of the Bureau of Medicine and Surgery there are special hospitals at which Navy and Marine Corps patients may receive treatment. One is the Army and Navy General Hospital at Hot Springs, Ark., where relief reasonably may be expected for the various forms of rheumatism, including muscular and articular conditions, after the acute inflammatory stage has passed; neuralgia and neuritis and metallic poisoning of a chronic nature; paralysis not of central origin; the earliest stages of locomotor ataxia and any other chronic degenerative change of nervous origin (insanity excepted) ; chronic nephritis and cardiorenal diseases (the early stages only) ; chronic skin diseases, especially the squamous varieties; arteriosclerosis; neurasthenic conditions, due to overwork, and other conditions accompanied by high blood pressure; certain metabolic diseases, such as gout, diabetes, obesity, etc.; chronic gastro-intestinal diseases which have not re- sponded to continued hospitalization at other places (gastric neuroses, post dysenteric colitis, chronic intestinal stasis, etc.). In Fitzsimons General Hos- pital, United States Army, at Denver, Colorado, cases of pulmonary tuberculosis may receive treatment. Insane cases are cared for at St. Elizabeths Hospital, Washington, D. C. (formerly known as the Government Hospital for the Insane). At Philadelphia, Pa., “a permanent asylum for disabled and decrepit Navy officers, seamen, and marines” has been established and is known as the United States Naval Home. Officers of the Navy or Marine Corps may be admitted to the benefits of the Naval Home by permission of the Secretary of the Navy. Enlisted men of the Navy or Marine Corps may be admitted to the benefits of ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 759 the Naval Home by authority of the Bureau of Navigation under the following classification: (A) Discharged enlisted men of the Navy or Marine Corps who have served in the Mexican War, the Civil War, the War with Spain, the Philippine Insur- rection, the World War, or any other service where the armed forces of the United States have been employed, and their lives hazarded in military opera- tions, and who are, by reason of wounds, sickness, old age, or other disability, xmable to support themselves by manual labor. (B) Discharged enlisted men of the Navy or Marine Corps who have become disqualified for further service by wounds, or injuries received, or by disease contracted in the service in the line of duty and who are unable to support themselves by manual labor. (C) Retired enlisted men of the Navy and Marine Corps unable to support themselves by manual labor. Applicants for admission to the Naval Home must be certified by a naval medical officer or a reputable physician as unable to support themselves by manual labor. Beneficiaries in the Naval Plome are quartered in separate rooms, are outfitted with the necessary uniform and such other clothing as may be deemed necessary upon admission, are issued such items of clothing quarterly as may be required for health and comfort, are given 1% pounds of tobacco per month, and when not in receipt of a pension are given an allow- ance of $3 per month for pocket money. When naval hospitals are not convenient, United States Army Hospitals, the hospitals of the United States Public Health Service, and the facilities of the Veterans’ Administration are available for the treatment of the Navy’s sick, and in emergency patients may be transferred to a civil hospital, as provided for by article 1143, United States Navy Regulations. The Surgeon General of the Navy is the Chief of the Bureau of Medicine and Surgery and its administrative head. Upon him devolves the formation of general policies and the maintenance of contact with: (а) The medical divisions of the fleets through the fleet surgeons; (б) The medical departments of naval stations through the senior medical officers; and (c) Naval hospitals, naval medical supply depots, naval medical and Hospi- tal Corps schools, and separate naval dispensaries or sick quarters through their commanding or senior medical officers. The assistant to the chief of the bureau, a naval medical officer, acts as the executive, has general supervision of the entire organization and work of the bureau, assists in the development of general policies, and in the absence of the Surgeon General becomes the acting chief of the bureau and signs all mail or official correspondence. The chief clerk has general supervision of the operation of the various bureau offices and becomes the acting chief of the bureau in the absence of both the chief of the bureau and the assistant to the chief of the bureau. For ease of administration and to facilitate the transaction of business, the bureau is divided into the following divisions: Administration, Personnel, Den- tistry, Physical Qualifications, Preventive Medicine, Aviation Medicine, Materiel and Finance, Inspections, Planning, Publications, and Red Cross and Veterans’ Administration. The duties assigned to each are indicated by the titles. MEDICAL DEPARTMENT PERSONNEL Comprising the personnel of the medical department are the members of four corps, the Medical, Dental, Hospital, and Nurse Corps. The Medical Corps 760 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY is composed of medical officers, the Dental Corps of dental officers, the Hos- pital Corps of commissioned warrant officers, warrant officers, and enlisted men, and the Nurse Corps of trained nurses. Medical and dental officers and nurses are appointed from civil life, the former by the President, by and with the advice and consent of the Senate, the latter by the Surgeon General with the approval of the Secretary of the Navy. Hospital corpsmen are enlisted or change their rating from other branches of the service to Hospital Corps ratings. Pharmacists (warrant officers) are appointed from chief pharmacist’s mates (enlisted men) by the Secretary of the Navy and chief pharrpacists (commissioned warrant officers) are appointed to that grade from pharmacists, being appointed by the President, by and with the advice and consent of the Senate. For full Information concerning the grades and ratings, appointments, pro- motions, and advancements, and the duties of the members of these corps, reference should be made to chapters 2 to 10, inclusive, and sections 2 to 4, inclusive, of chapter 12, Manual of the Medical Department. NAVAL HOSPITALS Legally, the title “naval hospital” can be applied only to those naval medical activities established as naval hospitals by order of the Secretary of the Navy prior to March 4, 1913, or authorized by act of Congress since that date. However, field hospitals and Navy base hospitals for foreign duty may, by competent authority, be classified as naval hospitals. All other medical facili- ties can be designated as dispensaries. The advancement made in hospital construction reflects itself in the many types of architecture found in naval hospitals. In addition to the main or hospital building, each hospital is equipped with other buildings necessary for the proper maintenance of the hospital, such as quarters for staff, power plant, laundry, garage, etc. To carry out the principal “mission” of naval hospitals the duties performed by Medical Department personnel will be found to be of two kinds, profes- sional or clinical and administrative. Professional duties are those primarily connected with the medical, surgical, dental, and nursing services. Each of these services is in charge of medical-department personnel designated by the commanding officer as Chief of Medical, Surgical, or Dental Service, and Chief Nurse. Under supervision of the Chief of Medical Service are the services of general medicine, psychiatry, laboratories, physical therapy, and out-patient; under supervision of the Chief of Surgical Service are the services of general surgery, eye, ear, nose, and throat, X-ray, urology, and orthopedics. The Chief of Dental Service has supervision of all dental work, and the Chief Nurse of all nursing. Administrative duties are those which concern organization, discipline, and training, maintenance and repair, preparation and preservation of records, preparation and serving of foods, procurement, custody, and disposition of prop- erty, etc. The commanding and executive officers are directly in charge of organization, discipline, and training, and the other administrative duties named, under their supervision, are directly in charge of naval pharmacists. Naval hospitals are commanded by an officer of the Medical Corps of the United States Navy, usually of the rank of captain, who is responsible to the Bureau of Medicine and Surgery for the care and treatment of the patients and for the discipline, cleanliness, and economic management of the Institution, and in turn exacts from subordinates, employees, and patients a proper obedience to his orders and to the laws and regulations of the Navy. All persons be- ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 761 longing to the Navy or Marine Corps who may be attached to the hospital or civilian employees in the hospital perform such duties as may be assigned them by the commanding officer. The general policies regarding the administration of naval hospitals are formulated in the Navy Department, but the commanding officer is responsible to the Bureau of Medicine and Surgery for the accom- plishment of those policies in such manner as he may deem most suitable to local conditions. The general orders regarding the operation of a naval hos- pital are in the main very similar at all institutions, as they are governed by the policies of the Navy Department; but the working details of these policies differ at the various hospitals, due to location, capacity, arrangement, etc. The policies of the Bureau of Medicine and Surgery and the Navy Department are sufficiently flexible to allow for these varying conditions, over which the commanding officer is given complete control. The medical officer next in rank to the commanding officer, unless otherwise ordered by the Navy Department, performs the duties of executive officer of the hospital. He is responsible to the commanding officer for the general functioning of the institution. The orders issued by the executive officer are the orders of the commanding officer, and therefore he always is well informed concerning the orders and policies of the commanding officer. Subject to the approval of the commanding officer, the executive officer directs all matters as regards duty assigned to personnel, discipline, leave, liberty, cleanliness, good order, etc. of the hospital. As he is the direct representative of the commanding officer, all requests or communications of any nature intended for the commanding officer must be taken up with him before being submitted to the commanding officer. Military etiquette demands that permission be obtained from the executive officer to communicate directly with the commanding officer. This is done in order that the executive officer may be informed regarding all matters pertinent to his office and at times relieve the commanding officer of minor details which can be adjusted by him. In the absence of the commanding officer, the execu- tive officer is recognized as the commanding officer and performs such duty during his absence. All medical officers attached to a naval hospital, other than those just men- tioned, are commonly designated as junior medical officers. They are assigned to the various activities of the hospital by the executive officer with the approval of the commanding officer. The assignment of these officers to duty in the wards, operating room, X-ray department, laboratory, etc., places them in charge of work performed within the activity concerned, and they are directly responsible for the proper performance of their duties, and in turn exact of the hospital corps- men and nurses under them strict attention to duty and proper performance of all orders issued by the commanding officer. The junior medical officers alternate in duty as officer of the day. An officer so acting is the representa- tive of the commanding officer and is responsible to him for compliance with orders and the maintenance of good order and discipline in the hospital. If the commanding officer and executive officer be absent from the hospital, he is responsible for the efficient management of the hospital and during their absence has the authority necessary for the enforcement of the orders and regulations governing the hospital. In the absence of an officer assigned as ward officer, the officer of the day is charged with the proper care of the sick in the ward concerned, and all information regarding patients which under ordinary conditions would be taken up with the ward officer, is communicated to the officer of the day, who issues orders accordingly. Hospital corpsmen take up all matters pertaining to the treatment of patients directly with the medical officer of the ward, or in his absence the officer of the day, and all details 762 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY regarding patients, liberty, leave, work, etc., must be approved by the ward officer before being submitted to the executive officer. All patients admitted to a naval hospital are received by the officer of the day or his representative; he also is informed of all discharges involving patients; and all attachments, transfers, or discharges of staff must pass through his hands. The replenishment of supplies, the upkeep, expenditure, accountability, and survey of property, management of the commissary department, and the cor- respondence and clerical work of the administrative offices of a naval hospital are duties performed by chief pharmacists and pharmacists. However, the commanding officer may direct that these officers perform other duties than those mentioned here. In order to accomplish this work, hospital corpsmen and civilian clerks are detailed in the offices concerned, under the direct charge of the chief pharmacist or pharmacist. In connection with the accountability of property great care has to be exercised at all times by hospital corpsmen, as it must be remembered that all equipment and supplies of the medical department are Government property and the laws governing their care and preservation are stringent and binding. Hospital corpsmen may be detailed for duty in any activity of the hospital as the commanding officer may direct. As it is the policy of the Bureau of Medicine and Surgery that hospital corpsmen’s duty shall be such as pertains directly with the care of the sick, all hospital corpsmen on duty in a naval hospital should thoroughly acquaint themselves with the orders and regulations govern- ing the hospital, in order that they can carry out faithfully such duties as may be assigned them and all instructions concerning the treatment of patients consigned to their care be conscientiously accomplished. A chief pharmacist’s mate customarily is detailed for duty as police petty officer of the hospital. He is responsible to the executive officer, and in his absence to the officer of the day, for such duties as may have been assigned him by the executive officer as regards the maintenance of discipline and order in the hospital and the various utility buildings of the hospital. Though the duties of a hospital corpsman at naval hospitals may, at times, seem disagreeable, such duties are often most im- portant from a nursing standpoint, and the accomplishment of such duties in the manner directed by the medical officer concerned will make much for the efficiency of the hospital and will be recognized only as part of that Intricate machinery called management. Under direction of the commanding and executive officers the nursing service of a naval hospital is under the direct supervision of the chief nurse. She instructs nurses in their duties, particularly as they pertain to the naval serv- ice, and sees that the orders of the executive officer and ward officers are carried out by the nurses under her. Nurses in charge of wards, operating rooms, diet kitchens, or linen rooms are given the necessary authority over patients and hospital corpsmen for the purpose of direct care of the sick and of ward or other work. They are held responsible for their conduct, attention to duty, and practical instruction in the details assigned to them. The work assigned hospital corpsmen in naval hospitals is considered as a training for the work to follow when they are assigned to duty on board men-of-war and on independent duty, when the instructions obtained in the hospital will be fully appreciated. The hospital has various special departments, such as dispensary, linen room, diet kitchen, etc., which are indirectly concerned in the treatment of the sick, but are necessary adjuncts to the hospital. These departments are in direct charge of a nurse or hospital corpsman, who is responsible to the executive officer for the proper performance of duty as directed by the commanding officer. ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 763 IT. S. NAVAL MEDICAL CENTER The Naval Medical Center, established by General Order No. 70, dated June 20, 1935, at Washington, D. C., consists of the Naval Medical School and the Naval Hospital, Washington, D. C. It is under the control of the Bureau of Medicine and Surgery, and functions as a medical, diagnostic, and educational center. Each unit of the Naval Medical Center has its own commanding officer. At the Naval Medical School postgraduate education is given medical officers and dental officers, and nurses and hospital corpsmen receive technical training in various subjects. XT. S. NAVAL DISPENSARY, WASHINGTON, D. C. The Naval Dispensary provides treatment for naval personnel attached to the Navy Department and their families, renders first-aid treatment and care to the civil employees of the Navy Department, and conducts special physical and other examinations. IT. S. NAVAL MEDICAL SUPPLY DEPOTS Three naval medical supply depots are maintained. The central depot is lo- cated at Brooklyn, N. Y., one at the Navy Yard, Mare Island, Calif., and one at Canacao, P. I. The central depot contracts for and purchases all supplies listed on the supply table and such other special equipment as may be required. It supplies the other depots with stock, also all shore stations on the Atlantic seaboard, and all ships operating in European, Atlantic, and South Atlantic waters. Mare Island supplies the shore stations on the west coast and ships in Pacific waters. Canacao supplies all ships and shore establishments in Asiatic waters. The medical supply depots are separate commands for officers of the Medical Corps. The staff usually consists of one or more chief pharmacists or pharma- cists, hospital corpsmen, and civil employees. HOSPITAL CORPS SCHOOLS Two schools are maintained for the instruction of hospital corpsmen, one at the Norfolk Naval Hospital, Portsmouth, Ya., and one at the Naval Hospital, San Diego, Calif. The commanding officers of these hospitals are also the commanding officers of the respective schools. The teaching staff consists of medical officers, chief pharmacists, pharmacists, and members of the Hospital Corps and Nurse Corps. CLERICAL WORK IN THE MEDICAL DEPARTMENT OF THE NAVY The clerical work in the medical department of the Navy required of hos- pital corpsmen may be explained most advantageously if separated into three divisions, as 1. General correspondence, i. e., letters, endorsements, etc.; 2. Requisition and voucher forms for the procurement of supplies and services; and 3. Reports and returns other than requisition and voucher forms. Correspondence. Correspondence or written communication in the Navy is divided into three general classes, which are official, semiofficial, and unofficial. (a) Official correspondence is communication between officers of the Navy and the offices and bureaus of the Navy Department, commanders in chief, 154294°—39 49 764 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY commandants, vessels of the Navy, naval stations, ships and stations, and with other executive departments by the office of the Secretary of the Navy. The subject matter usually embraces information concerning the activities, duties, and policies of the Navy, recommendations, reports, and knowledge of conditions in foreign countries which are of value to the transaction of public business. (6) Semiofficial correspondence usually is the communication of informa- tion in a partly official manner to a bureau or office in the Navy Department by officers under the direct cognizance of that bureau or office. (c) Unofficial correspondence is all communication not considered official or semiofficial. Official correspondence and information relating to any matter of such nature that special precautions should be taken to insure that information concerning it shall be permanently or temporarily limited in circulation is classified as secret, confidential, or restricted, and is defined as follows; Secret matter is matter of such a nature that its disclosure might endanger the national security, or cause serious injury to the interests or prestige of the Nation or any Government activity thereof. Confidential matter is matter of such a nature that its disclosure, while not endangering the national security, would be prejudicial to the interests or prestige of the Nation or any Government activity thereof. Restricted matter is matter of such a nature that its disclosure should be limited for reasons of administrative privacy; or, is matter not classified as confidential because the benefits to be gained by a lower classification out- weigh the value of the additional security obtainable from the higher classi- fication. Correspondence or information relating to methods of procedure regularly followed and to other subjects, a full knowledge of which could by no possi- bility be of use to an enemy is not considered as classified matter, constitutes a large part of correspondence, and is sometimes termed nonconfidential. Official correspondence within the naval service is carried on in the manner prescribed in detail by the Navy Regulations. While the substance of official correspondence concerning the medical department of the Navy is determined by the officers charged with such duty, its transcription into official form for signature and forwarding usually is entrusted to hospital corpsmen. For one preparing correspondence, it is most important to remember to keep a copy of every letter or endorsement prepared and to have a systematic method of numbering and filing all such papers, so that they can be referred to readily. A hospital corpsman detailed to perform clerical work should have access to a copy of the Navy Regulations, and the instructions in Chapter 52 thereof should be referred to whenever there is any doubt as to the proper form to be used or the method of procedure to be followed. In this section will be described only so much of the official instructions as will make clear the essential features of service correspondence by letter or endorsement. Correspondence must be courteous in tone and free from expressions of a personal nature, but courtesy shall be indicated by the substance and feeling rather than by artificially polite phrases and formulas. So far as is possible, and with due consideration of the public interests, the number of letters written and their length should be minimized. Accuracy, simplicity, and conciseness, especially in official correspondence, and confining letters to the one subject at hand without omitting necessary details and arranging the paragraphs of letters in logical sequence is most essential. If ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 765 adding to the clearness of a letter, the use of accompanying diagrams, tables, and sketches is permissible, but they should never be embodied in the letter. Communications from subordinates are sent to their superior officers for transmittal. If in proper form and language, the superior officer forwards them as soon after receipt as practicable, stating thereon in writing, by endorse- ment or otherwise, his opinion in relation to every part of the subject con- tained in the communication. To such papers as are complete in themselves and do not require an expres- sion of opinion from the office through which they are transmitted, the term “forwarded” may be affixed and such papers transmitted under the endorse- ment of an officer of the staff, by direction of the commander in chief, the commandant, or the senior officer present. As a general rule, letters shall be answered by letters and not by endorse- ment. This does not prevent the use of stamped or written endorsements on papers or reports copies of which are not retained, or the use of endorsements on papers necessarily referred to several bureaus or offices. This is intended to prevent unnecessary clerical work. When the original is answered by a separate letter each office has a complete record of the correspondence without extra work. Separate letters shall be written on separate subjects unless the subjects are of a like nature. The subject matter in a letter should be divided into paragraphs in logical sequence, each containing statements com- plete in themselves but all relative and pertinent to the subject at hand, and the paragraphs numbered. All communications, except such as require neither action nor reply, shall be acknowledged. Letters and endorsements shall be numbered and shall be typewritten if practicable, using noncopying ribbons and making a sufficient number of car- bon copies for filing or other purposes. If correspondence cannot be type- written, it should be written legibly and contain no erasures or interlineations. Carbon copies shall show the office of origin and the name of the signing officer shall be typewritten or stamped on all copies. In preparing letters, endorsements, and reports which go through another office or other offices, the office preparing the original will make on thin white paper a copy for each office through which the correspondence is to pass before it reaches its final destination. These copies will be marked for the appropriate office. Letter paper habitually is used for official correspondence in the Navy, whether letters or endorsements. For the original or first copy, it is white linen typewriter paper, 8 by 10% inches in size, weighing approximately 4% pounds per ream of 500 sheets of that size. For file copies, a green tinted paper of the same size and weighing about 3 pounds per ream is used. Thin paper other than green is used for additional carbon copies. Typewriter cap, used only in special cases, shall be 8 by 13 inches in size, but otherwise similar to letter paper. The paper used for letters and endorsements has two holes punched in it, the center of the holes one-half inch from the top of the sheet and 2% inches apart and equidistant from the center of the sheet. These holes permit the sheets to be fastened together uniformly. The following instructions relative to correspondence are quoted in full from article 2015, of U. S. Navy Regulations in order that they may be available for those who may not have ready access to a copy of that publication. “(1) The forms prescribed in this article shall apply to all correspondence within the naval service, with the State naval militia organizations, and with 766 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY such departments as may adopt a similar form of correspondence, but not with departments, officials, and persons that have not adopted these or similar forms. “(2) Letters shall begin with the ship or station, place and date, grouped and spaced as indicated in the examples in paragraph 27. The upper line of the heading shall be at least iy2 inches from the top of the page. In the case of endorsements which start on a new page, or any letter or endorsement con- tinued on a new page, there shall also be left clear at least 1% inches at the top for binding purposes. “(3) The official designation of all vessels of the Navy shall be the name of the vessel preceded by the letters U. S. S. The word flagship shall follow the name of the vessel in the heading of a communication emanating from the office of a flag officer. “(4) Special subletterheads may be used at shore stations to designate the different offices of the station, and by officers on detached duty ashore, but shall not be used to designate the different heads of departments on board ship. (See Example B and the last two examples under C.) “(5) In communications dated on board a vessel at sea, the latitude and longitude shall be stated if exactness be necessary, otherwise the expression ‘Passage, to ’ shall be used. “(6) Following the heading and date in letters and endorsements either the official designation, or the name and rank of the writer preceded by the word ‘From’, shall be written at the left side of the page as indicated in examples in paragraph 27. “(7) On the line below ‘From’, and preceded by ‘To’ at the left of the page, shall appear the official designation of the office or official addressed; following this the channel through which the communication is to pass; these offices to be designated by numerals indicating the sequence of routing. “(8) Following the address, the subject of the correspondence, briefed, shall be written across the page, preceded by ‘Subject’. “(9) The brief of the subject should be written in about the same form and terms as would be used in indexing the communication in filing; for example, ‘Delaware; feed pumps; recommends change in type’, ‘Navy Yard, New York; Dry-dock No. 1; reports damage to caisson struck by tug’. “(10) The subject shall not be repeated at the beginning of an endorsement, except when required by the filing system of the writer’s office to identify the file copy, or when the endorsement begins on a new sheet, in which case it shall always be repeated. “(11) After the subject the references to previous correspondence on the same subject, if any, shall be briefly indicated, preceded by ‘Reference’. Usually the references have been addressed either to the writer or to the addressee of correspondence, and it is necessary to indicate only the office of origin in references. Occasionally for clearness it is desirable to indicate the addressee of a referenced letter as shown in the form in paragraph 27. “(12) In acknowledging, answering, or referring to official communications, the file number (letters as well as figures), and date shall be included in the ‘Reference.’ References shall be lettered in small letters, and may be referred to in the communication as ‘Reference (a)’, etc. “(13) When a plan that has been given a file number is referred to in the correspondence, this number should be stated in connection with such reference. “(14) Following ‘Reference’, if any, the number of enclosures shall be stated preceded by ‘Enclosure’ at the left of the page, as indicated in the example in paragraph 27. ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 767 “(15) The use of numbered enclosure slips attached to the enclosures is authorized, and in case they are used the serial number of the slip or slips should be given after the word ‘Enclosures’. (See example B.) “(16) Where necessary the method of forwarding enclosures, whether enclosed under separate cover or by express, shall be indicated. The absence of ‘Refer- ence’ or ‘Enclosure’ will indicate that no reference or enclosure accompanies the communication. “(17) The file number of the letter or endorsement shall be placed in the upper left corner, about 1 inch from top and 1 inch from the left edge of the page; the abbreviation or initials of the section or division preparing the correspondence to follow on the same line as the file number. “(18) The body of letters and endorsements shall be written single spaced, with one double space between paragraphs. Each endorsement shall, where possible, be written on the same sheet as the preceding letter or endorsement, with a space of about one-half inch intervening. “(19) Paragraphs in letters and endorsements, or other official papers, shall be numbered. Subparagraphs shall be lettered thus: (a), (&), etc. “(20) The body of the letter shall begin and end without any ceremonial form or expression, such as ‘Sir,’ T have the honor to report’, ‘Very respect- fully’, etc., and shall be followed by the signature of the writer without desig- nation of rank, title, or office. Information will be imparted, reports made, and questions asked directly, dispensing with such introductory phrases as ‘The bureau informs you that’, ‘Information is requested as to’, ‘It is directed’, etc. “(21) In the body of the letter IT. S. Navy shall be abbreviated to U. S. N., U. S. Naval Reserve to U. S. N. R., U. S. Marine Corps to U. S. M. O., and U. S. Marine Corps Reserve to U. S. M. C. R. In the case of names of officers of the Staff Corps the designations as given in article 148 shall be abbreviated as follows: Medical Corps to M. C., Supply Corps to S. O., Dental Corps to D. C., Construction Corps to C. C., Civil Engineer Corps to C. E. C., Chaplain Corps to Ch. C., Professors of Mathematics to Math. “(22) When any article referred to in a communication is forwarded under separate cover, it shall be tagged and plainly marked in the following manner: ‘From Commanding Officer, U. S. S. , accompanying letter (or endorsement) No. , date ’ If possible this shall appear also on the box or package carrying the enclosure. “(23) Stamps showing the date of receipt of papers shall be so placed as not to occupy any writing space. If stamps constituting pro forma endorse- ments, such as ‘Received and forwarded’, ‘Referred for action’, etc., are used, they will be placed on the face of pages as though written in a more formal manner, and will be numbered as indicated in example. “(24) Endorsements, whether written or stamped, except those referred to in the next paragraph, shall be placed in regular order, beginning on the last page of the letter, immediately below the signature, if there be room there; if not, additional full sized sheets shall be appended to the letter to accommodate them. Endorsement slips shall not be used, except on corre- spondence with other departments using such slips. “(25) All endorsements affecting pay, mileage, transportation, and traveling expenses shall be placed on the face of the original order involving travel, if practicable, otherwise on the back of the order. Such endorsements shall never be placed on sheets which might be detached from the original order. “(26) Only one page of the sheet shall be written upon, and a margin of % inch shall be left on each side and at the bottom of the sheet. 768 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY “(27) The following are examples of the forms of correspondence prescribed in this article: Example A No. 122-3. U. S. Navy Yard, Philadelphia, From: Commandant, Navy Yard, Philadelphia. To: Commanding Officer, U. S. S. Southwark. Via: (1) Construction Officer. (2) Engineer Officer. Subject: U. S. S. Southwark—Repairs to boat crane. References: (a) Comdg. Off. let #576-D, of 27 April, 20. (b) Dept. let. 2345-432, of 30 April, 20, to Bu. of C. & R. Enclosures: (A) (separate cover) Blueprint #1234 showing proposed arrangement of boat crane. (B) (herewith) Copy of previous correspondence on this subject. 1. The repairs to the boat crane of the U. S. S. Southwark are to be under- taken by the ship’s force. The yard force will give such assistance as may be necessary in this connection, and you will please be governed accordingly. SO June, 1920. A. B. __ 1st endorsement No. 324-S-OD. U. S. Navy Yard, Philadelphia Construction Department, 1 July, 1920. From: Construction Officer. To: Commanding Officer, U. S. S. Southwark. Via: Engineer Officer. Subject: U. S. S. Southwark—Repairs to boat crane. 1. The commanding officer has been consulted concerning the desired repairs, and the necessary material therefor under the construction department will be furnished. Estimated cost: Labor $10 Material 80 Indirect 40 Total 130 C. D. 2d endorsement No. 411-237-PW. U. S. Navy Yard, Philadelphia Engineering Department, 5 July, 1920. From: Engineer Officer. To: Commanding Officer, U. S. S. Southwark. Subject: U. S. S. Southwark—Repairs to boat crane. The construction officer and commanding officer have been consulted, and the necessary material under the engineering department for the proposed repairs will be furnished. ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 769 Estimated cogt: Labor $8 Material 60 Indirect 30 Total 98 E. F. 1382-67-C. O. Example B. Navy Yakd, Puget Sound, Wash., Hull Division, 6 May, 1920. From: Construction Officer. To; Commandant. Subject: Quick-drying paint. References: (a) Bureau C. & R. letter 4048-A-306 of 14 March, 20. (6) Bureau C. & R. letter 4048-A-139 of 27 July, 19. (c) Bureau C. & R. letter 1808-B-912 of 12 Feb., 20. Enclosures : #13821 & #13822. 1. I request that the Bureau of Construction and Repair furnish formula for manufacturing slate-color, quick-drying paint mentioned in the first para- graph of reference (c). 2. Also request information as to the proper formula for boot topping on battleships. The second paragraph of reference (c) states that black quick- drying paint is used for boot topping on vessels painted slate color. Reference (?>) gives black boot topping formula for use on torpedo boats, destroyers and colliers, but states nothing about modifying previous instructions regard- ing boot topping for battleships, the last instructions received on that point being in reference (c). Attention invited to enclosure #13822 showing sam- ples of boot topping used on ships at the yard, and that mixed according to reference (c). A B 12879-136-c 1st endorsement. Navy Yabd, Puget Sound, Wash., 7 May, 1920. From: Commandant. To: Bureau of Construction and Repair. Subject: Quick-drying paint. Enclosure: #13822. 1. Approved and forwarded. E F G Example C. (Form of letterheads and subletterheads.) Navy Department Bureau of Construction and Repair Washington, D. C., 1 July, 1912. 770 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY U. S. S. Connecticut Hampton Roads, Va., 1 July, 1912. United States Atlantic Fleet U. S. S. Connecticut, Flagship Navy Yard, New York, 1 July, 1912. U. S. S. Connecticut (Passage, New York to Hampton Roads) 1 July, 1912. Navy Yard, New York Captain of the Yard’s Office 1 July, 1912. Navy Yard, Boston Hull Division 1 July, 1912. Navy Yard, Norfolk Machinery Division 1 January, 1913.,> The sheets of a letter or report shall be arranged in regular order from bottom to top; i. e., the first sheet on the bottom, the last sheet on top. Enclosures, if any, shall be attached in regular order on bottom of the letter, all securely fastened together, the head of the fastener underneath and the ends turned over the face of the correspondence in order that the last sheet may be readily removed to place endorsements thereon. Additional sheets bearing endorsements shall be attached, each on top of the preceding one, on the face of the correspondence, so that the last endorsement shall be uppermost. Whenever an endorsement begins on a new sheet the subject shall be repeated. Each page of letters and endorsements shall be numbered in the middle of the page about one-half inch from the bottom. These numbers shall run consecutively throughout the correspondence. When folding is necessary, letter paper shall be folded in three and type- writer cap in four equal folds parallel to the writing. All papers of whatever nature which by law or regulation must be signed, approved, or forwarded by an officer commanding a fleet, squadron, division, or station, the commandant of a naval station, the senior officer present, or the commanding officer of a ship, actually must be signed by such officer in his own handwriting. In his absence they shall be signed by the line officer next in rank and actually in command at the time, and the word “Acting” shall be written or stamped after his signature, but the title of the official from whom the communication emanated, as indicated after the word “From” at the beginning of the paper, shall not be modified. The name of the officer signing also shall be typewritten or stamped. Thus, in the absence of the Chief of the Bureau of Navigation, the words “Bureau of Navigation” still would appear in the letterhead, and the acting chief of bureau would write “Acting” after his signature. “Acting” shall not be used by officers left in command of ships or divisions. When the officers in charge of sections of a bureau or office are authorized to sign mail of their section, they write or stamp the words “By direction” after 771 ADMINISTRATION AND GENERAL CLERICAL PROCEDURES their signature, and the title of the bureau or office shall appear in the pre- scribed place at the head of the communication. Communications generally are addressed to those who by regulation or law have cognizance of the subject presented or are authorized to take action thereon. Official communications intended for officers holding positions with recognized titles are addressed to them by title and not by name, as “The Secretary of the Navy,” “Bureau of Navigation,” “The Commandant,” “The Commander in Chief, Fleet (or Squadron),” ‘The Commander, Squadron (or Division),” “The Commanding Officer.” Officers left in temporary command of a station, fleet, squadron, or division, or in general, of any command, are addressed as if they were the regular com- manding officer, on the principle that it is the office and not the person that is addressed. The temporary incumbent transacts the business so that the necessary copies and records shall be preserved in the files of the absent superior officer’s office, using stationery of that office when practicable. For the purpose of expediting public business between offices of the department or within any command, mail shall be regarded as consisting of three classes-— urgent, important, and ordinary. “Urgent” mail shall be given precedence over all other, and in order that it may be readily distinguished, it shall have affixed to it a red slip, 2 by 3 inches in size, with “Urgent” printed thereon. “Important” mail shall be given precedence after urgent mail and shall bear a blue slip with the word “Important” thereon. In general, “ordinary” mail shall be handled in the order in which received. Official mail received on board ship, or at any station, shall be opened at once by the officer actually in command for the time being, or his designated representative, and all papers requiring prompt action given immediate attention. Official communications for the Navy Department or any of its bureaus or offices are addressed directly to the bureau or office which has cognizance over the subject matter. It is prohibited to address communications to “The Navy Department” or to “The Navy Department ( ).” The following are examples of authorized addresses: The Secretary of the Navy. The Assistant Secretary of the Navy. The Chief of Naval Operations. The President of the General Board. The Chief of the Bureau of The Major General Commandant, Marine Corps. The Judge Advocate General. The Chief Clerk of the Department. When papers are addressed erroneously and reach any bureau or office under the jurisdiction of the Navy Department they are turned over to the bureau or office to which they should have been properly addressed without action thereon. No written communication is official which has not been forwarded through the prescribed channels and with the endorsements of the officers through whom it should have been forwarded. All officers are required to file and preserve all official documents received and copies of all official letters and endorsements sent. Suitable files containing copies of all orders given and official letters written and the original of all letters received on public service in all offices on board 772 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY naval vessels and at shore stations shall be kept and preserved. Commanding officers may take copies of orders or letters sent and received. The system of filing shall be such as to safeguard all official papers and to render them readily accessible to reference. A flat filing system shall be used when practicable. United States Navy filing system. A uniform system of filing all correspondence by subjects with key letters and numbers was adopted by the Navy in 1923. This system, the rules for which are contained in the United States Navy Filing Manual, must be strictly adhered to. The subject titles are so arranged as to be as nearly as possible self-indexing. To this end the activities of the Navy have been divided into seven main parts and each part designated by a letter. These are: (1) A Administration. (2) F Aircraft material. (3) H Hydrography, meteorology, navigation, and astronomy, (4) L Logistics. (5) N Shore establishment material. (6) P Personnel. (7) S Material of ships. The activities under each of these main parts have been so arranged that those of correlative nature or having the same general purpose are grouped together and each group assigned a descriptive file arrangement title with its corresponding file number. For example, the personnel groups run thus: PI Genealogy and identification. P2 Preventive medicine. P3 Medicine. P4 Surgery. P5 Dentistry. P6 Death and casualties. P7 Domestic relations. P8 Social relations. P9 Political relations. P10 Amusement and recreation. Pll Education. Pi 2 Religion. PI 3 Misconduct and discipline. P14 Appointment. P15 Commendations, citations, and medals. P16 Assignment and detail. P17 Rank, precedence, and promotion. PI8 Attendance and absence. P19 Separation (personnel). P20 Performance. P21 Morale. In selecting a file number from the index, it should represent a specific title. Example: An endorsement is to be placed on an officer’s request for leave from the Naval Hospital, Washington, D. C. By referring to the index it is found that the file number for that hospital is NH6, the subject of the endorsement is leave of absence. Again referring to the index it is found ADMINISTRATION AND GENERAL CLERICAL PROCEDURES 773 that P18-1 covers that subject. If correspondence for personnel is filed in individual jackets for those concerned, then the letter J is also added. All letters and figures are now joined, but each block is separated by a slant (/). Thus the complete file number is NH6/P18-1/J and twTo carbon copies should be prepared, one for file under P18-1 and one for the jacket J. A copy of the filing manual is to be found in each office. Organization of clerical force. The clerical work required of the medical department of a ship or hospital is carried on largely by members of the Hospital Corps. When hospital corpsmen are on independent duty the preparation and forwarding of the various reports and returns required is entirely in their care, and unless they have prepared themselves for this work it is very confusing to the bureau and entails unnecessary work in the attempt to gather accurate data from incorrect and carelessly made reports. The duties in a naval hospital comprise all that relates to the replenish- ment of supplies, the upkeep, expenditure, and survey of property, the com- missary department and the correspondence and clerical work of the record section incident to the above, as well as the filing of all permanent records. Clerical activities at a naval hospital are usually divided into four sections, i. e., personnel or record office, accounting office, property office, and commis- sary department. Aboard ship the clerical work comprises all the work required at naval hos- pitals, except commissary, and is not divided. A chief pharmacist’s mate is usually in charge, the whole being under the supervision of the medical officer. BLANK FORMS AND RETURNS OF THE MEDICAL DEPARTMENT OF THE NAVY OTHER THAN REQUISITION AND VOUCHER FORMS To secure uniformity and accuracy of the reports and returns connected with the duties of the medical department of the Navy certain blank forms for specific purposes have been provided. To designate these forms they are lettered or numbered, and they usually bear other letters indicating that they belong to the Bureau of Medicine and Surgery. The data contained in these reports are the basis for all of the bureau’s statistical compilations, and become permanent and highly important records of the Navy Department. The Bureau of Medicine and Surgery is compelled to rely upon them for the medical histories of the officers and enlisted men of the Navy when requested to furnish specific information of importance demanded by other departmental bureaus and of vital concern to the individual. It is therefore obvious that these reports must be without error. In combining and tabulating these reports an error in any one makes the whole faulty and im- pairs any deductions made from such statistics. To assure the uniformity and accuracy desired and to aid those wrho prepare these forms, detailed instructions for preparing each particular form are printed on the form itself, or the information desired is fully indicated in the printing and wording of the form. A great difficulty with printed instructions of this character is that those for wThose guidance they are intended do not read them and consequently do not comply strictly with the directions given. Only by strict compliance with instructions can mistakes and needless correspondence be avoided. Before attempting to prepare any bureau form or report it is therefore essential to read carefully the instructions pertaining to the form and to understand their meaning. 774 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY These forms, as well as the instructions for preparing them, are subject to change, and therefore the form itself should always be resorted to for the necessary directions as to its preparation. In transacting the business of the Medical Department of the Navy many reports and returns other than those pertaining to that department must be prepared as occasion requires. General and detailed instructions concerning their preparation are contained in bureau manuals and circular letters, or on the forms, and in all cases should be strictly followed. Hospital corpsmen whose examinations for advancement in rating include the subject of Administration and General Clerical Procedures must famil- iarize themselves not only with the contents of all sections in this section hut with those parts of bureau manuals, Navy Regulations, Naval Courts and Boards that pertain to the subject. References Handy Book for the Hospital Corps, 1917. U. S. Navy Regulations. Manual of the Medical Department. Bureau of Navigation Manual. Hospital Corps Handbook, U. S. Navy, 1923. Handbook of the Hospital Corps, U. S. Navy, 1930. Section 2.—HOSPITAL SUPPLIES AND PROPERTY ACCOUNTABILITY The title of this secton, usually spoken of by the term Property and Accounting, as employed by the Medical Department of the Navy, comprehends the procurement, custody, and final disposition of property under its cognizance, and the accounting procedures concerned therewith. It is essential, therefore, that all personnel of the Medical Department, particularly hospital corpsmen, understand the subject and be familiar with the terms in common usage and the routine procedures. In this section the terms and procedures will be covered generally by definitions, explanations, and illustrations. A study of the Manual of the Medical Department, U. S. Navy, and other official publications, for details and directives, is recommended to all personnel, especially to those whose duties are in any way concerned therewith. In general, medical-department property is of two classes—equipment and supplies. At naval hospitals “land and buildings” constitutes a third class. Equipment is property that is not consumable, i. e., not easily breakable (as hospital furniture) or not readily rendered unfit for. service by continued use (as surgical instruments). Consumable materials and personal services are classified as supplies. In order to determine if an item is equipment or supplies reference should be made to the Supply Table and Supplementary Supply Table. Items not specifically listed therein should be classified accord- ing to the classification of similar or identical items in the supply tables, and should be grouped by classes in the equipment or supplies ledger according to the listing of similar or identical items in the Federal Standard Stock Catalog. Property accountability and accounting procedures. Article 1194, U. S. Navy Regulations, holds the medical officer in command of each hospital, and the medical officer of each station and ship responsible and accountable for all public property under his control belonging to the Medical Department of the Navy. HOSPITAL AND PROPERTY ACCOUNTABILITY 775 In order to avoid unnecessary expenditures of public money or stores and to attend to the care and preservation of Government property, an accurate account of property under the cognizance of the Medical Department must be kept. This is accomplished by the utilization of certain accounting records, bookkeeping procedures, reports, and returns. The following paragraph, quoted from the Code of Laws of the United States, Title 5, section 430, fixes the responsibility of the Bureau of Medicine and Surgery for its books of records and accounts: “The several bureaus shall retain the charge and custody of the books of records and accounts pertaining to their respective duties, and all of the duties of the bureaus shall be performed under the authority of the Secretary of the Navy, and their orders shall be considered as emanating from him, andt shall have full force and effect as such.” It is impracticable for the Bureau of Medicine and Surgery to attend to all the details of accounting for monies and materials for each Individual station and ship. Therefore there have been established accounting systems for use by naval hospitals and by ships and stations. Reports and returns forwarded by medical-department activities at regular intervals provide the bureau with the information necessary to carry out its financial responsibilities and control its financial obligations. At each naval hospital there is established a Property and Accounting Office in which correspondence, records, reports, returns and documents required in the handling of the financial affairs of the hospital are prepared and maintained. This department is usually under the charge of a chief pharmacist or pharma- cist designated as the Accounting Officer with an assistant designated as the Property Officer, although the duties of both these officers may be combined. In addition to such other duties as may be assigned them the duties of officers assigned to the Property and Accounting department of a naval hospital are as listed immediately hereafter. The accounting officer— 1. Is the assistant to the commanding and executive officers in financial and property matters; 2. Is responsible for the accounting records and keeps the commanding officer informed relative to the status of allotments, expenditures, etc. Keeps the Land and Buildings, Equipment, and Supplies Ledgers and is responsible for their accuracy; 3. Supervises the preparation of requisitions, public vouchers, payrolls, invoices, requests for allotments, surveys, annual estimates and advanced years’ estimates of expenditures, and all other forms and reports pertaining to financial matters; 4. Submits to the commanding officer, via the executive officer at the end of each month, a report on the condition of allotments, and a statement of the balances available, or prospective over-obliga- tions, if any, with reasons therefor; and 5. Keeps himself informed of the laws, regulations, and instructions governing the preparation and submission of accounting records and reports and keeps the books of account and financial records of the hospital. The property officer— 1. Is custodian of all stores and equipment belonging to the hospital, exercising personal and careful supervision over them and the 776 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY economical use and expenditure thereof, reporting any deficiencies to the accounting officer; 2. Receipts for, issues, and accounts for all stores (except commissary stores) and equipment; 3. Maintains the proper records of equipment issued to the several serv- ices and facilities of the hospital, obtains and retains in file custody receipts therefor, and reports any deficiency in property charged to these activities to the accounting officer; 4. Takes an actual inventory of stores (except commissary stores) on hand at the end of each quarter and reports to the accounting officer any differences in the amounts as shown on the books and as determined by actual inventory; 5. Correlates the inventories from the various activities as of 30 June, each year, and prepares the annual inventory for submission to the bureau; 6. Is responsible for the management and accounting of the pharmacy unless the commanding officer shall specifically except this responsi- bility from his assigned duties; and 7. When detached or relieved, makes a complete inventory of all equip- ment and supplies (except commissary stores) and transfers them to his successor. The accounting system prescribed for naval hospitals is based upon double- entry bookkeeping principles modified to provide data essential to central con- trol and internal management. Such elements of appropriational, cost, and fiduciary accounting as will provide the necessary data are utilized in this system which is designed to suit the needs of all naval hospitals regardless of size or of the number of administrative units into which each hospital may be divided. A knowledge of the fundamental principles of double-entry bookkeep- ing procedure is necessary to the proper understanding of the accounting system in use at naval hospitals. As a detailed discussion of the fundamentals of bookkeeping is beyond the scope of this section, and in view of the fact that ac- counting instructions are contained in Chapter 20 and Circular Letter F, Appendix D, Manual of the Medical Department, U. S. Navy, only brief mention of medical department accounting records and reports will be made here. Naval hospitals.—The accounting records required to be kept at each naval hospital are: 1. Journal.—The Journal is a book of original entry in which is recorded, either in detail or in summary form, the debit and credit effects of financial transactions. 2. Charge Register.—The charge register is a columnar subsidiary journal record in which is recorded the debit and credit effects of financial transactions involving the receipt of property, except property received by transfer voucher or taken up from inventory adjustment vouchers. 3. General Ledger.—The general ledger is the control or master ledger in which is recorded the debit and credit effect of every receipt and expenditure of property. Postings to this ledger are made only from the Journal. 4. Land and Buildings Ledger.—The land and buildings ledger is an itemized record of the receipt and expenditure of land and buildings items. 5. Equipment Ledger.—The equipment ledger is an itemized record of the receipt and expenditure of all equipment items. 6. Supplies Ledger.—The supplies ledger is an itemized record of the receipt and expenditure of all consumable supplies except provisions. HOSPITAL AND PROPERTY ACCOUNTABILITY 777 7. Commissary Ledger.—The commissary ledger is an itemized record of the accounts of the commissary department, both as to quantity and cash value of provisions. 8. Expense Analysis Register.—The expense analysis register is a cost analysis of the hospital operating expense subdivided to show: (a) The operating cost by departments; (ft) the expenditures on account of pay of the military staff; and (c) the expenditures made for the Navy as a whole. 9. Recapitulation of Ledger Accounts. (Register No. 3).—The recapitulation of ledger accounts is prepared quarterly and when decommissioned, in dupli- cate, and is forwarded to the bureau not later than 15 days after the close of each quarter. In addition to the recapitulation of general ledger accounts this form furnishes a recapitulation of each Expense Analysis Register account and information related to both recapitulations. When forwarded it is accom- panied by other required financial reports and supporting data. The duplicate copy is retained in the files of the accounting office of the activity submitting the report. 10. Quarterly Ration Return. {N. M. S. II. Form 36).—The quarterly ration re- turn is prepared in duplicate, quarterly and when decommissioned, and the original is forwarded to the bureau with the Recapitulation of Ledger Ac- counts (Register No. 3). This report supplies the bureau with information as to subsistence furnished personnel, the amount of reimbursement received or to be obtained by the bureau therefor, the value of provisions received and expended, and the average daily cost of ration. Ships and stations.—The accounting system for shore stations other than naval hospitals and for ships consists principally of records of the receipts and expenditures of materials and services and of records of appropriational ex- penditures and obligations. The following financial records are required to be kept in the operation of this system; 1. Journal of Receipts and Expenditures of Medical Department Property.— This journal is the book of original entry for stations and ships and is used to record data relative to each financial transaction involving the receipt and disposition of medical-department property. It should be posted daily, or as frequently as may be necessary to keep the record up to date. Each entry should be substantiated by a duly authenticated voucher (N. M. S. Form 4 invoices, stub requisition summaries and stub requisitions, public vouchers, transfer vouchers, surveys, issue vouchers, etc.) and the vouchers should be preserved in such manner as to be readily accessible for reference or audit purposes. At the close of each quarter and upon decommissioning, each amount column in the Journal should be totaled and the sums entered on the Statement of Receipts and Expenditures of Medical Department Property (N. M. S. Form E). 2. Equipment Ledger.—In this ledger a sheet (N. M. S. Form W) is kept for each item or group of identical items of equipment arranged by Supply-Table classes, Supplementary Supply-Table classes, and Federal Standard Stock Cata- log classes. A control sheet for each class and a master' control sheet for all classes should be kept. Receipts of equipment are posted in this ledger from the data contained in the substantiating voucher following posting of the total amount of the voucher in the Journal of Receipts and Expenditures of Medical Department Property. Expenditures of equipment are posted to this ledger from approved surveys and transfer vouchers, following posting in the Journal. 3. Supplies Ledger.—In this ledger a sheet (N. M. S. Form W) is kept for each item or group of identical items of supplies arranged by Supply-Table 778 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY classes, Supplementary Supply-Table classes, and Federal Standard Stock Catalog classes. A control sheet for each class and a master control sheet for all classes should be kept. Receipts of supplies are posted in the same manner as are receipts of equipment. Expenditures are posted from issue vouchers (N. M. S. Form R.), transfer vouchers issued, and inventory adjustment vouch- ers, in the same manner as expenditures of equipment are recorded. New unit costs of items are determined and recorded on the ledger sheets upon receipt of additional items having a unit cost greater or less than the unit cost then appearing on the ledger sheets. Accounting records and reports used hy the Medical Department provide sta- tistics of two kinds: Appropriational, and cost. By appropriatlonal accounting is meant the procedures involved in recording and analyzing the value of receipts of materials and services obtained by reason of the expenditure or transfer of funds from appropriations under the cognizance of the Bureau of Medicine and Surgery or from the Naval Hospital Fund. Cost accounting concerns the pro- cedures involved in recording and analyzing the value of materials and services consumed in the operation of an activity regardless of the source from which such materials and services may have been received. N. M. S. Form B is the report of allotment expenditures and obligations used in appropriational accounting and is forwarded to the bureau quarterly by all medical-department activities required to submit financial returns. This form is designed to report expenditures as follows: By appropriation, and by objects of expenditure and subheads under objects, including totals expended for supplies, for equipment, and, at naval hospitals, naval medical supply depots, and the naval medical school, on land and buildings. It furnishes information concerning the allotment status as to amount available at the beginning of the period covered by the report, amount expended during the period covered by report, and obligations outstanding and unexpended balance at end of the period. It also analyzes the expenditures reported to show the source (stub requisition, purchase requisition, bureau work request, etc.) of materials, sub- divided according to the appropriations chargeable. On the face of the form are reported the expenditures under the supply depot credit allotment, the status of that allotment, the data concerning each medical supply depot requisition received during the accounting period covered by the report, and the data with respect to each such requisition outstanding at the close of the accounting period. On the reverse of this form is reported an analysis of the receipts from medical supply depots by supply table classes and subheads, subdivided into supplies, equipment, and mortuary supplies and equipment. This analysis is prepared by consolidating the cost data shown on the reverse of all naval medical supply depot requisitions and invoices (N. M. S. Form 4) actually receipted by the activity during the accounting period covered by the report. {See sample forms on pages 798 to 893, inclusive). It is essential that accurate information be furnished on Form B as it is used in the bureau for many purposes, chiefly to fiirnish the information required for allotment control and analyses of expenditures by subheads. N. M. S. Form E is the statement of receipts and expenditures of medical- department property and is forwarded to the bureau by such ships and stations as are required to submit medical-department financial returns. It is designed to furnish a perpetual inventory control and cost analysis, and reports the receipt and expenditure of all materials and services, regardless of source, divided into equipment and supplies, and analyzes certain receipts and expendi- tures. Incidental information as to operating expense, complement, and medical HOSPITAL AND PROPERTY ACCOUNTABILITY 779 services rendered civilians is supplied on lines 46 to 55 inclusive. (See sample form on pages 796 and 797). The information contained on all N. M. S. Forms E submitted is consolidated in the bureau. In order to coordinate the various expenditures and consider the entire problem of financing the Medical Depart- ment, it is essential that this report correctly reflect the financial affairs of the reporting activity. The initial financial record is the allotment card covering the allocation of funds to medical-department activities. Allotment cards, on each of which is shown the name of the appropriation, the allotment number, and the amount of money allotted, are forwarded by the bureau to shore stations with the returned annual estimate of expenditures, as approved. Allotment cards for ships are prepared and forwarded by the bureau. Except for supply-depot credit allotments, the total amount allotted is divided into quarterly appor- tionments, the amount apportioned for each quarter depending upon the estimated requirements of the activity during each quarter. Allotments are classified by the Bureau of Medicine and Surgery as appro- priational (money credits) and medical supply depot (material credits). Appropriational allotments are money credits made to medical-department activities from the Congressional appropriations Medical Department, Navy, and Care of the Dead, Navy, and from the Naval Hospital Fund, and represent the amounts reserved or set aside by the bureau exclusively for the activities to cover the anticipated expenditures and transfers of funds in the procurement of the materials and services necessary to carry out the mission of the Medical Department. Medical supply depot allotments are material credits authorizing withdrawals of equipment and supplies from stock at naval medical supply depots and are measured in terms of money for convenience. In such withdrawals no dis- bursement or transfer of funds is involved because the materials were paid for from funds allotted to the medical supply depots for that purpose. The stock available for issue at medical supply depots is procured from funds allotted by the bureau to the depots annually, prior to 1 July, to cover regu- larly stocked Supply-Table and Supplementary Supply-Table items estimated to be required by all medical-department activities for one year. Upon receipt of the allotment cards, the medical department of an activity is prepared to initiate the procedures necessary to obtain the needed materials and services for its proper function. Procurement. The financial duties of the Bureau of Medicine and Surgery are set forth in Sections I and II, Chapter 20, Manual of the Medical Department, U. S. Navy. Not all monies under the cognizance of the Navy Department are appropri- ated funds; there are also Working Funds and Trust Funds. A notable example of a trust fund, and one of interest to hospital corpsmen, is the Naval Hospital Fund which derives its revenue from within the naval service and is administered by the Secretary of the Navy, the Trustee. The sources of revenue of this trust fund are; 1. By the deduction of 20 cents per month from the pay of each officer, seaman, and marine (Sec. 4808, R. S.). 2. By fines imposed on officers, seamen and marines (Sec. 4808, R. S.). 3. By the value of one ration per day allowed for each officer, seaman, and marine, during his continuance in hospital (Sec. 4812, R. S.). 154294°—39 50 780 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY 4. By the relinquishment of disability pensions due officers, seamen, and marines (other than Veterans’ Administration beneficiaries) while inmates of naval hospitals (Sec. 4813, R. S.). 5. By forfeitures on account of desertion (Act of June 7, 1900, 31 Stat. 697). Monies required for the maintenance and operation of medical-department activities are made available from two sources: Annual appropriations and a trust fund. Services and materials are procured for the medical depart- ment of ships and stations and at hospitals both from the money appropriated and from the Naval Hospital Fund, the trust fund just mentioned. Annual appropriations are made by the Congress for expenditure during a specified fiscal year. The annual appropriations included in the Appropriation Act for the Naval Establishment which pertain to the Bureau of Medicine and Surgery are titled as follows; (a) Medical Department, Navy; (&) Care of the Dead, Navy; and (c) Salaries, Bureau of Medicine and Surgery The detailed purpose of expenditure under the fixed title of appropriations is contained in each annual appropriation act. The language of the appropri- ation controls expenditures to be under that appropriation. For example, the annual appropriation, Care of the Dead, Navy, by its title presupposes, and correctly so, that expenditures for the care of the remains of the dead are payable from this appropriation. The language of this appropriation reveals the specific objects such as funeral expenses, recovery of bodies, cremation, preparation for burial, transportation, burial expenses of pensioners and desti- tute patients, and so forth. The language of an appropriation or fund must be studied carefully to determine the one to which an expenditure is chargeable. It should be remembered therefore that the appropriations and funds are not interchangeable and do not constitute a lump sum to be expended as desired. Rather, the language of the act, naming a specific purpose or object, prevents the use of funds from a less specific appropriation for that particular purpose or object. The Naval Appropriation Act for each fiscal year contains the wording of the annual appropriations; Chapter 20, Manual of the Medical Department, U. S. Navy, defines expenditures to be made from the Naval Hospital Fund. Funds to operate a naval hospital or the medical department of a naval station are obtained by the medium of an annual estimate of expenditures. As ships have approximately the same expenses from year to year the bureau does not require individual ships to submit an annual estimate, but allots funds, by classes of ships, on an average expenditure basis. Under ordinary circumstances, a medical-department activity should not incur any appropriational obligations unless, and until, an allotment for the purpose has been granted by the bureau. Certain contingencies indicated in Article 1396, U. S. Navy Regulations, permit the commanding officer to authorize appropriational expenditures without an allotment. In each such case, however, a full report of the emergency must be made to the bureau in order that provisions may be made to meet the expenditure. The annual estimate of expenditures may be defined as a detailed analysis and itemization of the appropriational expenditures which, it is expected, will be required to provide the submitting activity with the materials and services necessary for its maintenance and operation for a stated period. As the manner HOSPITAL AND PROPERTY ACCOUNTABILITY 781 of submitting estimates and the data required to be submitted to the bureau with each estimate is subject to change, the current circular letter on the subject should be consulted before preparation. An annual estimate is submitted to the bureau by shore stations to cover the period of one fiscal year from 1 July of one to 30 June of the next calendar year. Another estimate, known as “Tentative Estimate, Advance Fiscal Years” is also submitted annually. For example, an annual estimate would be sub- mitted for the period: 1 July, 1942, to 30 June, 1943. The tentative estimate for advance fiscal years is submitted for the two fiscal periods immediately following the period covered by the annual estimate, in this case for the period 1 July, 1943 to 30 June, 1944, and for the period 1 July, 1944 to 30 June, 1945. Annual estimates are reviewed in the bureau and when approved constitute a fiscal guide for1 the activity. The preparation of an annual estimate is not a one-man job. The full cooperation of all persons having to do with materials and services is essential to a complete and intelligent estimate covering requirements for all departments. The data required for the preparation of estimates should be collected from official weekly inspections, notes, experience data, and so forth, classified and filed for reference. Materials and services may be obtained on the following official request forms, duly prepared and accomplished: 1. Purchase Requisitions (S. & A. Form 76 and 76a ashore, and S. & A. Form 44 and 44a afloat) ; 2. Stub Requisition (Local memorandum invoices) ; 3. Requisition for Labor (N. Y. O. Form 6) ; 4. Bureau Work Request (Special M. & S. Form) ; 5. Medical Supply Depot Requisition and Invoice (N. M. S. Form 4) ; and 6. Transfer Vouchers (Usually S. & A. Form 71). In order that a supply officer may make a payment legally, he must have definite authority therefor. The approval of a purchase requisition by the cognizant bureau, or bureaus, constitutes the necessary authority to make payments. A purchase requisition, therefore, may be defined as an authorization to the supply officer designated thereon to make a contract in accordance with the terms of the requisition. Regarding the expenditure of funds of the Medical Department of the Navy it should always be borne in mind that officers of the Supply Corps and Marine Corps Quartermasters are the only persons in the naval service who may make appropriational expenditures, an exception sometimes icing made when the Chief of the Bureau of Supplies and Accounts specifically designates an officer as Special Disbursing Agent. It naturally follows, therefore, that the appropriational expenditures reported by medical department activities must agree with the appropriational expendi- tures reported by the supply officer. Procurement by requisition, in contrast to procurement by transfer, pre- supposes prior approval of a requisition and an allotment of sufficient funds to cover the cost. An allotment of funds may be defined as evidence of a credit which has been established for the maintenance, operation, Improvement, or extension of a specified medical-department activity. The sum allotted is based upon general and specific projects of an approved fiscal plan. Contrary to general opinion, if sums allotted are in excess of needs for approved projects, due to over-estimates, deferred projects, or otherwise, the excess is not available 782 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY for accomplishment of unapproved projects, without specific approval for such use. It should be borne in mind that a project is approved prior to the allotment of funds. Certain minor procurements of materials and services are required fre- quently by medical-department activities. It would be impracticable for an activity to submit a purchase requisition to the bureau for approval in each such case, prior to obtaining the necessary materials or services. This situation is met by the submission and subsequent approval of annual purchase requisitions covering such recurring needs throughout the fiscal year. The language of such requisitions is approximately as follows: For hospitals and large stations For sundry items of supplies, equipment and services, including services of Mood donors, in such quantities and at such times as may be required during the fiscal year 19—. (The services of blood donors are omitted from requisitions drawn under the Naval Hospital Fund because such services are provided for in and are chargeable to the appropriation Medical Department). For ships and small stations For sundry items of medical and dental supplies; special diets for the sick; laundry supplies and services; services of blood donors; repair of and parts for medical-department equipment; repair of and parts for motor vehicles; in such quantities and at such times as may be required during the fiscal year 19—. (Requests for dental supplies and repair of and parts for motor vehicles are omitted from requisitions submitted by ships and stations having no dental officer and at which there are no medical-department motor vehicles). As may be seen, the approval of an annual purchase requisition authorizes a supply officer to make contracts for the purchase of a variety of items, accord- ing to the language appearing on the requisition. The proposed method of procurement of each item on the approved annual estimate of expenditures must be given, that is, whether by Special Purchase Requisition (SR), Annual Purchase Requisition (AR), Stub Requisition (S), or Bureau Work Request (BWR). The method by which an item will be procured is determined by the source from which it is to be obtained as follows: (o) Obtain on N. M. S. Form 4 requisition, if the item is listed on the Medical Department Supply Table or Supplementary Supply Table. (6) Obtain on stub requisition, if the item is listed in the Federal Standard Stock Catalog as Navy material. (c) Obtain on Bureau Work Request, if work involved in connection with the item is beyond the capacity of the hospital force employed. (d) Obtain on purchase requisition, if the item must be procured in the open market where a cash payment is involved. In determining the method of procurement of an item the sources of supply are to be considered in the following order of priority: 1. Naval Medical Supply Depot; 2. Supply Officers’ stores; 3. Bureau Work Request, to be performed by yard labor or Public Works contract; and 4. Purchase requisition. HOSPITAL AND PROPERTY ACCOUNTABILITY 783 The three naval medical supply depots are located in Brooklyn, N. Y.; Navy Yard, Mare Island, Calif.; and Canacao, P. I. Supply-Table and Supple- mentary Supply-Table stores are purchased in large quantities by the procuring depot at Brooklyn, and stored locally, or in the naval medical supply depots at Mare Island and Canacao. Issues from these depots are usually made under the authority of an N. M. S. Form 4 requisition, approved by the bureau. The items listed on the requisition are boxed by the depot and shipped to the medical officer requesting them through the facilities of the Supply Department. The bureau provides tables listing items stocked, for issue, at naval medical supply depots. The tables are known as the Supply Table of the Medical Department, U. S. Navy, and the Supplementary Supply Table of the Medical Department, U. S. Navy. Instructions as to ordering, and limitations on particular items, are contained in each table. Items carried in stock by the local supply officer may be withdrawn on stub requisition for use provided funds are available in the appropriate allot- ment of the medical-department activity. The form of stub requisition to be used may differ at various activities. When labor (including incidental materials) is required for maintenance of buildings, ambulances, or other items of equipment, and such labor is beyond the capacity of the force employed, an M. & S. “Bureau Work Request” form is submitted covering the project. Custody. From the date of procurement (receipt) of medical-department property until the date of its disposition an individual member of the medical department is responsible, in a fiduciary capacity, for its custody. The custody of medical-department property includes the accountability, inspection, and storage of such property and Article 1132, U. S. Navy Regula- tions delegates to the medical officer of each ship the charge of all material and stores on board which are under the cognizance of the Bureau of Medicine and Surgery. Medical officers in command of naval hospitals and the medical officers at shore stations are likewise held responsible for medical-department property in their charge by Article 1194, U. S. Navy Regulations. Persons charged with the custody of medical-department property are not relieved of responsibility therefor until custodianship is regularly transferred to a suc- cessor in accordance with existing instructions, or is disposed of by survey. Also, by U. S. Navy Regulations, officers are required to avoid any unneces- sary expenditure of public money or stores, and so far as may be in their power prevent the same in others, and to attend to the care and preser- vation of all Government property in their charge. Hospital corpsmen who are custodians of or whose duties are concerned with the care of medical-department property are expected to do everything in their power to preserve such property and prevent its loss, waste, or unauthorized use. They also are expected to be thoroughly familiar with the instructions governing the custody of and accountability for medical-department property as contained in the U. S. Navy Regulations and the Manual of the Medical Department, U. S. Navy. As the details of the inspection and storage of medical-department property vary with the location of activities they will not be discussed in this section. Disposition. Equipment and supplies consumed in any given period result in a depletion of material inventories and a change in the total value of stock on hand; 784 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY therefore, records are needed to reflect the physical and financial changes and to provide an administrative control. The primary form used to record storeroom issues at medical-department activities is N. M. S. Form R. Some materials and services are issued without passing through the storeroom, such as payment of salaries and wages to civil employees; bulky stores such as coal or fuel oil; special medicines in small amounts procured locally and consumed immediately upon receipt; etc. Nevertheless an issue voucher, or other docu- ment, covering such supplies is essential: 1. To record the issue authorization; 2. To relieve the storekeeper of responsibility; and 3. To substantiate the necessary entries in the accounting records. After materials are issued from the storeroom of a medical-department activity the issue vouchers are cbmpleted by entering the unit and extension prices on them and the total quantity and cost of each item is then recorded as an expenditure on the respective ledger sheets of the appropriate ledger. Records of quantity and cost of materials withdrawn are tabulated from these vouchers and entered on ledger sheets. A recapitulation of such issues is recorded in the Journal of Receipts and Expenditures of Medical-Department Property at stations and on ships, and in the Expense Analysis Register at hospitals. These recapitulations form the basis for the expenditure entries made on N. M. S. Form E and in the Statement of Expense Analysis Register Accounts on the reverse of N. M. S. Register No. 3, respectively. Equipment and supplies under medical-department cognizance may be trans- ferred to another naval activity or to another Federal activity in emergencies or as a matter of expediency. Such a transfer constitutes an expenditure “by transfer.” The first step in the accounting procedure is the invoicing of the material on Bureau of Supplies and Accounts Form No. 71. When receipted, this form constitutes the duly authenticated voucher required to substantiate the entries in the accounting records and reports with regard to the disposition of the material transferred. Equipment in excess of requirements, missing, worn out, or otherwise unfit for use, is required to be made the subject of a property survey. Surveys are requested and the reports are recorded on Bureau of Supplies and Ac- counts Form No. 154. U. S. Navy Regulations and Chapter 20, Manual of the Medical Department, U. S. Navy, contain complete instructions governing survey procedures. Surveys of property are of two types—formal and informal. The fiduciary (custodial) accountability for property may be terminated by means of a properly executed property survey. The term, property, embraces both medical-department supplies and equipment. A property survey is the act of inspecting Navy materials (property) by a duly appointed officer or board of officers with a view to determining and reporting facts regarding the desig- nated property items and making appropriate recommendation concerning the disposition of such items. The recommended disposition of medical-department property which has been so inspected (surveyed) is subject to the approval of the Bureau of Medicine and Surgery. To this end, the surveying officer or survey board performing the acts of inspection submits a report on the prescribed form (S. & A. Form No. 154), listing in the space provided the condition, cause, re- sponsibility, recommendation, and appraised value of each item. A formal survey is a property survey performed by a surveying officer or survey board appointed by the senior officer present. A survey board con- sists of one or more naval officers, at least one of whom must be commissioned. An informal survey is a property survey performed by the head of depart- HOSPITAL AND PROPERTY ACCOUNTABILITY 785 raent having charge of the property. No survey board or surveying officer is appointed in cases of informal survey. To determine whether a property survey shall be formal or informal, with respect to medical-department property, the instructions published in Chapter 20, Manual of the Medical Department, U. S. Navy, should be followed. A formal survey is required: (а) When an item of equipment has a book value in excess of $25, or a group of identical items has a book value in excess of $100; (б) When the head of department is not a commissioned officer; and (c) When specifically directed by the commanding officer of a ship, or the commandant or commanding officer of a shore station. An informal survey may be held when none of the foregoing restrictions apply. The form used for reporting a property survey is S. & A. Form No. 154. An effort should be made to conserve forms and to this end, where all items can- not be listed on the form itself, the additional items may be listed on standard typewriter paper. The form is designed so that all information with respect to a particular item will be on one page. The upper half only of each sh(eet is to be used for listing the items to be surveyed, the lower half being reserved for use of the surveying officer in reporting the condition, cause, responsi- bility, recommendation, and appraised value of the items appearing in the upper part of the same sheet. When additional sheets are required and are prepared on standard typewriter paper, each sheet shall be divided into two parts in the same manner as S. & A. Form No. 154 is divided. The upper part of the additional sheets shall be used for listing the items to be surveyed and the lower part for the report on the items appearing in the upper part. The condition, cause, responsibility, recommendation, and appraised value, required to be indicated for each item are explained as follows: Condition refers to the actual physical condition with relation to the original purpose, that is, broken ; hinges sprung; leaky; chipped; etc. Cause refers to the reason the item is in its present condition, if such can be determined. The usual causes are: Worn out in use; excess; lost; acci- dentally dropped; damaged by fire; or some other happening or event which brought about the present defects. Responsibility refers to the person or persons who caused the item to be defective. Usually no responsibility attaches to articles worn out in use or rendered defective by some unavoidable act, the usual report as to responsi- bility being: None; Responsibility cannot be fixed; etc. Recommendation refers to the opinion of the board regarding the most appro- priate disposition of the item. The usual recommendations are; Destroy; To naval medical supply depot (naming the depot) ; To supply department for sale; To yard scrap heap; or, Retain and repair on ship or station. The Manual of the Medical Department, U. S. Navy, paragraph 3076, contains detailed instructions with respect to the recommendations mentioned. The surveying officer, or survey board, is required by Article 1911, U. S. Navy Regulations to state in the recom- mendation for disposition whether or not replacement is required. Appraised value is the estimated monetary value of the item in its present condition. Items recommended for transfer to a naval medical supply depot for repair or for further disposition, or to a supply officer for sale or exchange shall, in each case, be assigned a conservative appraised value. The original and two copies of property survey reports on medical-depart- ment property are submitted to the Bureau of Medicine and Surgery for items 786 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of equipment or supplies all of which are recommended to be destroyed. Para- graph 3076, Manual of the Medical Department, U. S. Navy, should be consulted for the correct number of copies required to be submitted in cases where the disposition recommended is other than destruction. When the survey report is returned to the ship or station by the bureau as “approved” or “approved as modified”, the recommendations appearing thereon should be carried out. The commanding officer appoints an officer to supervise the destruction of all items approved to be destroyed, and after destruction is completed the officer so appointed places an endorsement to this effect on the survey report. Items to be transferred or retained are handled by the property and accounting officer or the medical officer in accordance with the recommenda- tion for each item as it appears in the approved survey. The individual items surveyed are written off in the Equipment Ledger, the Supplies Ledger, or the Land and Buildings Ledger, depending on the nature of the items. At naval hospitals, the value of the material disposed of by authority of approved survey is accounted for in the hospital’s financial records and is ultimately reported on N. M. S. Register No. 3. On ships and af; stations the value of the material so disposed of is recorded in the Journal of Receipts and Expenditures of Medical-Department Property and is ultimately reported on the appropriate line, and in the appropriate analysis, on N. M. S. Form E. In order to emphasize the importance of maintaining, in the proper manner, the Journal of Receipts and Expenditures of Medical Department Property on board all ships and at all stations required to submit N. M. S. Forms B and E, samples of these forms have been prepared and are reproduced at the end of this section. These sample forms are intended to demonstrate by example the manner in which the Journal should be prepared and maintained, the method of preparing financial reports, and the relation of each form to each of the others. A detailed discussion of the entries in the sample N. M. S. Forms B and E will not be undertaken here. Instructions for the preparation and submission of these forms are covered fully in Circular Letter F, Appendix D, Manual of the Medical Department, U. S. Navy. An understanding of the purpose of each form and its relation to each of the others can be most readily obtained by tracing each entry in the sample Journal to the various lines, tables, and analyses on the sample N. M. S. Forms B and E. The comments on medical-department accounting procedures appearing next are made in order that the reader may observe the procedures in concrete form and thus obtain a working knowledge of the proper method of recording and reporting transactions involved in the procurement and disposition of medical department property on board ships and at stations. Allotment expenditures to liquidate obligations against allotments for a previous year are reported monthly on supplementary N. M. S. Form B until all obligations outstanding at the close of the previous fiscal year are liquidated. However, on board ships and at stations, the materials or services received by reason of the incurrence of such obligations are considered to be current receipts and are properly taken up in the Journal as at the date of liquida- tion and are reported as receipts on the N. M. S. Form E for the quarter in which the obligations are liquidated. In the sample forms this procedure applies to S. D. Requisitions Nos. 14-40, 16-40, and to Public Voucher No. 1-12 (40). By reference to the sample forms it will be noted that bills of lading covering the transportation of remains are recorded and reported as though they were HOSPITAL AND PROPERTY ACCOUNTABILITY 787 public vouchers. This procedure is followed because charges for transportation of remains, authorized by Government bill of lading or transportation request, are ultimately liquidated by public voucher. Expenditures for transportation of remains are made by disbursing officers in the same manner as other expend- itures on public vouchers. In view of the long period of time which ordinarily elapses between the incurrence of the obligation and the payment for the trans- portation of remains, and since a very accurate estimate may be obtained from the initial carrier, the estimated cost of transportation of remains as obtained from the initial carrier is taken up by the medical-department activity shipping the remains from a memorandum voucher prepared for that purpose. The estimated cost of transportation is recorded as a receipt by public voucher in the Journal and in the Supplies Ledger. An issue voucher (N. M. S. Form R) is prepared immediately following the preceding entry and is recorded as an expenditure in the Journal and in the Supplies Ledger. It is reported as an appropriational expenditure on N. M. S. Form B, and as both a receipt and an expenditure on N. M. S. Form E, for the accounting period in which shipment is made. Adjustment of the expenditures reported by the medical-department activity is made in the Bureau of Medicine and Surgery when the changes are finally paid. Obligations for transportation of remains in foreign countries, when liquidated locally by authority of public vouchers, are taken up in the Journal and the Supplies Ledger and are reported on N. M. S. Form B for the accounting period in which the public voucher is dated. When materials are procured under a contract which does not include free delivery to the medical-department activity, the cost of transportation is added to the purchase price as an allotment charge and as a part of the book value of the material. Transportation charges on such items are always paid for from the Naval Supply Account Fund, a revolving (working) fund under the cognizance of the Bureau of Supplies and Accounts, but the appropriation paying for the material obtained on the contract is ultimately chargeable with the cost of transportation. The transportation charges, when paid, are taken up in the Naval Supply Account, by a supply officer, as though they were actually material and the cost is charged to the Naval Supply Account Fund. In order to charge the cost of transportation to the appropriation paying for the material obtained on the contract, and in order that the medical-department activity for which the material was purchased may be furnished the necessary information for entry in the accounting records and financial reports, the transportation charges are transferred as “material” to the Appropriation Purchases Account and the Naval Supply Account is credited. At the time the transportation charges are transferred from the Naval Supply Account to the Appropriation Purchases Account the cost of transportation is charged to the appropriation paying for the material obtained on the contract and the Naval Supply Account Fund is credited. Up to this point all transactions and accounting procedures in con- nection with the transportation charges are handled by officers of the Supply Corps. The medical-department activity concerned clears the transportation charges through the Appropriation Purchases Account by furnishing the supply officer, in whose account they are lodged, with an accomplished stub requisition. As the appropriation paying for the material obtained on the contract has also been charged with the transportation cost the stub requisition invoicing such cost is taken up by the medical-department activity concerned as a charge to its allotment under that appropriation and is recorded in the Journal in the column headed N. S. A. material. Transportation charges being a part of the gross cost of placing the material in a “ready to use” status at the activity 788 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY are therefore an integral part of the “book value” of the material and are taken up on the ledger sheet recording the description and purchase price of the material. In the sample forms this procedure applies to the transportation charges on the ambulance. In connection with the preceding discussion of transportation charges on material purchased on contract, attention is invited to the fact that the cost is charged to the appropriation for the fiscal year in which the supply officer actually takes up the charges in his Appropriation Purchases Account and not to the appropriation current at the time the material was purchased. For example, an ambulance may be paid for from the appropriation Medical Depart- ment, Navy, 1941 while the transportation charges incurred in its delivery may be paid for from the appropriation Medical Department, Navy, 1942. In connection with the property surveys recorded in the sample Journal it will be noted that Survey No. 1-41 is recorded as having been approved by the Bureau of Medicine and Surgery during the fiscal year 1940 and that the typewriter value to be expended in accordance therewith is recorded as having been expended on the first day of the fiscal year 1941. The fact that Survey No. is so recorded is explained by the assumption that the survey was submitted during the month of June, 1940, accompanied by Special Purchase Requisition No. 4-41, in order to comply with instructions which require that purchase requisitions for replacement typewriters be accompanied by the survey request and report on the typewriters to be replaced and that they be forwarded to reach the Bureau of Medicine and Surgery not later than 15 July of each year. Annual contracts for1 the procurement of typewriters expire on 31 July of each year. Obviously, if the field activity is located at a considerable distance from the bureau the survey and requisition will, of necessity, have to be forwarded prior to the beginning of the fiscal year in which they are to become effective in order to insure compliance with instructions. Even though the approved survey had been received by the activity prior to 1 July, 1940 the typewriter value to be expended in accordance therewith will not have been expended until, or after, that date. The fact that Survey No. 6-40 was not expended during the fiscal year 1940, although the date of approval by the Bureau of Medicine and Surgery is recorded as 3 June, 1940, may be explained by assuming that the approved survey was not received by the activity until 1 July, 1940 after the Journal for the fourth quarter of the fiscal year 1940 had been closed. The fact that it apparently was received on the same date as Survey No. 1-41, approved by the bureau 17 days later, is explained by the fact that surveys on ambulances and motor vehicles must be returned to the activity via the Bureau of Yards and Docks in each case and also via the Bureau of Supplies and Accounts when transfer to a supply officer for sale or other disposition has been recommended. The reader should note that the value to be expended by survey is expended upon receipt of the original of the survey bearing the approval of the Bureau of Medicine and Surgery, or on the first day of the fiscal year in which series it is numbered, and that the expenditure is not held in abeyance until any items having an appraised value have been disposed of in accordance with the approved recommendation of the surveying officer or survey board. A transfer of material is not complete until the receipted transfer voucher issued, signed hy the officer to whom the material is invoiced, has been received by the activity issuing the transfer voucher. The accountability for the material remains vested in the activity transferring it until such time as the signed receipted transfer voucher is received from the activity which is to take up the material in its accounting records. The value of the material transferred HOSPITAL AND PROPERTY ACCOUNTABILITY 789 should be expended from the accounting records only after receipt of the transfer voucher, accomplished as stated before, regardless of the period of time inter- vening between the transfer of the material and receipt of the accomplished transfer voucher. Therefore the expenditure of such material should appear in the Journal and on the N. M. S. Form E for the quarter in which the properly accomplished Transfer Voucher Issued is received. The expenditure will appear in the Journal and the financial reports for the quarter in which the material is transferred only when the signed receipted transfer voucher is received in the same quarter as that in which the material was transferred. A signed receipted copy of all Transfer Vouchers Issued must accompany financial reports for the quarter in which the material so transferred is expended from the accounting records of the activity. The preceding comment is applicable to T. V. I. No. 12-40 as recorded in the sample Journal and the sample N. M. S. Form E. It should be noted that the value of Naval Supply Account (N. S. A.) material received on stub requisitions has been taken up in the sample Journal from the monthly Summary of Stub Requisitions (S. & A. Form 178) and not from the individual stubs received at the time each issue was made by the supply-department activity from which the material was obtained. The indi- vidual stubs for each month should be filed in numerical sequence until the stub summary is received at the end of the month. The charges shown on each individual stub should be checked against the charges reported on the stub summary. In the event discrepancies are found the supply department should be contacted and the necessary adjustments made to bring the total money value of the individual stubs into agreement with the total money value reported on the stub summary. The stub summary should not be signed by the medical officer until appropriational charges have been verified. This procedure should be followed for the reason that individual stubs furnished at the time the material is issued are subject to adjustment for final appro- priational charge by the accounting officer of the supply-department activity furnishing the material. After verification of the stub summary the charges shown thereon should be entered in the Journal and in the appropriate ledgers. The charges for equipment and the charges for supplies should be segregated and entered in their respective sections of the Journal and in their respective ledgers. The total money value of the summary, as verified, is reported on N. M. S. Form B as an allotment charge. The transactions incident to the procurement and disposition of typewriters and other office machines and devices being rather involved, and requiring strict compliance with instructions, the subject of replacement of typewriters will be discussed in detail. During the progress of this discussion reference should be made to the entries recording Survey No. 1-41, T. V. I. No. 1-41, Public Voucher No. 4-1 and A. P. A. Stub No. 54 in the sample forms. Typewriters for use of the medical department afloat are purchased from funds under the cognizance of the Bureau of Supplies and Accounts while those for use of the medical department ashore are purchased from funds under the cognizance of the Bureau of Medicine and Surgery. Typewriters for use of the medical department afloat are obtained from the supply officer on custody receipt and no medical-department accounting procedures are involved. The annual estimate from shore stations should contain provision for type- writer replacements and additions because they may not ordinarily be obtained otherwise. Annual contracts are made by the Procurement Division of the Treasury Department with all leading manufacturers of typewriters and the General Schedule of Supplies lists each company’s machine and the 790 HANE BOOK OF THE HOSPITAL CORPS, U. S. NAVY contract price for each model by item number. The particular make and model to be purchased is left to the discretion of the activity requiring the machine. When the replacement of typewriters is authorized in the annual estimate the procedure to accomplish replacement is as follows: 1. Submit a property survey on S. & A. Form No. 154, to the Bureau of Medicine and Surgery, listing only the machines to be replaced. The make, model number, length of carriage in inches, and serial number must be given for each typewriter listed in the request section of the form. No other items should be listed in the survey. In addition to the routine data applicable to all property surveys, a survey of typewriters must contain a statement by the surveying officer or survey board as to whether or not the carriages and main frames are broken. The recommendation should be “To Supply Department for sale or exchange”. The appraised value of each typewriter for which replace- ment is recommended must be stated as the trade-in allowance listed in Class No. 104 of the General Schedule of Supplies for the current year. 2. A specific purchase requisition, original and seven copies of S. & A. Forms Nos. 76 and 76a, shall be prepared and submitted to the Bureau of Medicine and Surgery with the property survey. If the new typewriters are authorized in the annual estimate no letter of transmittal is required. The item number, detailed description, and the contract price as given in the General Schedule of Supplies, as well as the kind of type and size of carriage desired, must be stated for each typewriter requisitioned. The total contract price of all the typewriters requisitioned shall also be stated. Following the entries concerning the last machine requisitioned must be listed: (a) The name; (6) Model number; (c) Serial number; (d) General Schedule of Supplies item number and exchange value as shown in Class No.-104; and (e) The condition of the carriage and main frame, for each machine to be exchanged on the purchase of the new machines. The total exchange allowance shall be deducted from the total contract price of the new machines to determine the net cost of the requisition. The item number, object and subhead number, and project number, as given in the approved annual estimate, shall be shown following the aforementioned data. 3. Upon receipt of the approved property survey from the bureau the dif- ference between the original book value and the appraised value stated in the survey is expended in the equipment section of the Journal and on the Equipment Ledger sheet. The machine is then transferred, on a Transfer Voucher Issued (S. & A. Form 71), to the nearest supply officer and his signature covering receipt is obtained on the voucher. Upon receipt of the accomplished Transfer Voucher Issued the typewriter value transferred to the supply officer is also expended in the equipment section of the Journal and on the Equipment Ledger sheet. Whether or not the typewriter is retained by the medical department for use pending receipt of the new machine is a local administrative matter. If retained, the typewriter value shall be invoiced to the supply officer as stated before and the supply officer furnished with a custody receipt. The custody-receipt transaction has no effect on the books of account. 4. Upon receipt of the new machine and the invoice, a public voucher is prepared under the Naval Hospital Fund, at naval hospitals, and under the appropriation Medical Department, Navy, at shore stations. The description of the new machine is listed in detail and the contract price is extended to the money value column. Immediately below, in the item column, are inserted the words “Less exchange allowance on (name of) typewriter num- ber surveyed on property survey number and the amount of the allow- HOSPITAL AND PROPERTY ACCOUNTABILITY 791 ance is extended in the money value column. The net amount to be paid on the voucher is determined by deducting the exchange allowance from the con- tract price and is inserted. By reference to the sample forms it will be seen that the contract price is stated on public voucher No. 4r-1 as $70.00, the exchange allowance as $15.00, and the net amount of the voucher as $55.00. In the section of the public voucher (Standard Form No. 1034) headed “Account- ing Classification” the following information must be recorded: In the first of the four columns from left to right, insert the Navy symbol number and the General Accounting Office symbol and subhead numbers of the appropria- tion or fund chargeable; in the second column insert the name of the appro- priation or fund chargeable; in the third column insert the title and account chargeable (13-X-2 in this case) ; and in the fourth column insert the net amount chargeable to the appropriation or fund. In the two columns under the heading “Cost Account” is inserted the account number and name of the nearest stores activity to which is attached a supply officer who renders stores returns to the Bureau of Supplies and Accounts. The symbol numbers, sub- head numbers, and the name of each appropriation and fund under the cog- nizance of the Navy Department are stated in the annual Appropriation Bulletin prepared and distributed by the Bureau of Supplies and Accounts. The account number of each naval activity may be found in the List of Accounting Numbers of Ships and Stations published annually by the Bureau of Supplies and Accounts. 5. When the public voucher is “abstracted” to the stores activity by the Bureau of Supplies and Accounts, the supply officer will take up in his Appro- priation Purchases Account the net amount paid, in this case $55.00. The supply officer will then have in his Appropriation Purchases Account a total of $70.00, representing the $15\00 taken up from the Transfer Voucher Issued and the amount of $55.00 taken up from the public voucher. It will then be neces- sary for the medical-department activity to furnish the supply officer with an Appropriation Purchases Account (A. P. A.) stub requisition in the amount of $70.00. 6. At stations, other than naval hospitals, the amount of the A. P. A. stub requisition representing the trade-in allowance on the surveyed typewriter (in this case $15.00) is taken up in the Journal as h Transfer Voucher Received and is so reported on line 7 and under the analysis of transfer vouchers received on N. M. S. Form E for the quarter in which received. At naval hospitals the amount of $15.00 is taken up by Journal entry debiting equipment account and crediting transfer vouchers received account, and is so reported on N. M. S. Register No. 3 for the quarter in which received. In either case the amount of $15.00 is entered on the equipment ledger sheet as a receipt from the Supply Department. 7. If a copy of the 13-X-2 public voucher is furnished the medical-department activity, the amount of $55.00 charged to the appropriation is taken up by stations in the Journal, under public vouchers, and is so reported on line 4, and under the summary of public vouchers paid, on N. M. S. Form E and in tables 1, 2, and 4 on N. M. S. Form B for the quarter in which taken up. At naval hospitals the hmount of $5&.00 charged to the Naval Hospital Fund is taken up in the Charge Register, debiting the amount in the equipment column and crediting the amount in the vouchers payable column, and is so reflected on N. M. S. Register No. 3 and in tables 1, 2, and 4 of N. M. S. Form B for the quarter in which taken up. At either stations or hospitals the amount of $55.00 is entered on the equipment ledger sheet as a receipt by public voucher and this is the only amount of the transaction to be reported as an appropriational expenditure on 792 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY N. M. S. Form B under object 32 and subhead 65. The exchange allowance on the surveyed typewriter is taken up as A. P. A. material, at no allotment charge, as the surveyed typewriter was paid for from funds under the cognizance of the Bureau of Medicine and Surgery at the time it was purchased. The A. P. A. stub invoicing the exchange allowance represents typewriter value in the form of the appraised value of the surveyed typewriter previously transferred to the supply officer and taken up by him in his Appropriation Purchases Account. The value is returned on the A. P. A. stub in the form of an allowance on the new typewriter and no charge against an appropriation is incurred by the transaction. To determine the book value of the new typewriter the value of the exchange allowance is added to the amount paid by public voucher. 8. In the event a copy of the 13-X-2 public voucher is not furnished to the medical-department activity the amount charged to the appropriation or fund ($55 in this case) is taken up from the A. P. A. stub requisition following exactly the same procedure as if a copy of the voucher had been furnished. In conclusion the reader must remember that the scope of this section is limited, and all hospital corpsmen, especially those whose rating subjects them to assignment to duty independent of medical officers or who are assigned to duty in connection with property and accounting, are again reminded that the information contained herein must be supplemented by constant refer- ence to and study of the U. S. Navy Regulations, the Manual of the Medical Department, U. S. Navy, the Bureau of Supplies and Accounts Manual and Memoranda, other bureau manuals, and such instructions relative to this subject as are issued from time to time. 793 HOSPITAL AND PROPERTY ACCOUNTABILITY RECEIPTS U) .(!).. (1) (1) (1) EQUIPMENT SECTION Date Medical Supply Depot Supply Dept. N.S.A. Material Public Vouchers T.V.R. Other M. D. Activitfcs T.V.R. as A.P.A. Material Remarks 7-2-40 18.16 S.D. Requisition No. 14-40.Class 7.Reported on supplementary Form B.F.Y.1940 7-15-40 87.15 S.D. Requisition No. 1-41. Class 15 7-18-40 100.00 T.V.R. No,1-41. 10 beds from Naval Hospital, Great Lakes, Illinois. 8-2i-40 6.00 Special Issue Requisition No. 15-41. Class 16. 3-15-40 15.00 A.P.A. Stub No.28. Deck Clock. (No allotment chapgei 8-30-40 55.00 Public Voucher No. 4-1. Typewriter. 8-31-40 35.00 Stub Summary, August. Fire Extinguishers. 9-30-40 1.250.00 P.V.#876.(Abstracted by Bu.S&A) Buiok ambulance, U.S.N. No. 4095. 9-30-40 15.00 A.P.A. Stub No.54. Exchange allowance on typewriter.(No allotment charge) 9-30-40 62.30 A.P.A. Stub No.61. Transportation on Buick ambulance. (Allotment charge) Totals 111.31 97.30 1.305.00 100.00 30.00 FIRST QUARTER TOTALS. F.Y. 1941 3 3 4 6 7 Lines on rtiioh reported on NMS Form "E" NOTE: (1) Always taken up In the equipment ledger by Individual items, except that transportation charges on equipment are added to the cost of the equipment and the exchange value of typewriters Is added to the cost of the typewriters. JOURNAL OF RECEIPTS AND EXPENDITURES OF MEDICAL DEPARTMENT PROPERTY EXPH1DITDRES (U (2) (2) FISCAL YEAR, 1941 EQUIPMENT SECTION Date Surveys T.V.I.to Supply Office: for Sale T.V.I. to other Med.Dept. Activities Remarks 7-1-40 50.00 Survey No. 1-41. approved by Bu.M&S 6-20-40. (Typewriter) 7-1-40 1,340.00 Survey No. 6-40. approved by Bu.M&S 6-3-40.(Ambulence) Book value $1,390.00 7-9-40 15.00 T.V.I. No. 1-41, Appraised value of survey No, 1-41 (Typewriter) 7-20-40 10.00 T.V.I. No. 2-41. Appraised value of beds on survey No.8-40,approved by BuM&S 6-13-40. 8-30-40 60.00 T.V.I. No.12-40. Lockers to N.A.S.,San California on 5-12-40. 9-15-40 50.00 T.V.I. No. 3-41. Appraised value of ambulance on survey No, 6-40. Totals 1,390.00 75.00 60.00 FIRST QUARTER TOTALS, F.Y, 1941 11 12 13 Lines on which reported on NMS Form "E" NOTE: (2) Always charge off individual Items In equipment ledger. JOURNAL OF RECEIPTS AMD EXPENDITURES OF MEDICAL DEPARTMENT PROPERTY FISCAL YEAR. 1941 794 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY REG (3) EIPTS SUPPLIES SECTION (*) (5) (3) (3) Date Medical Supply Depot Supply Dept. N.S.A. Material Public "touchers Pay Roll, Civil Employees T.V.R. other M.D. ActivitlBs T.V.R. as A.P.A. Material Remarks 7-5-40 10.00 PV#1-12{40).Special diets.June.Reported on supplementary Form B.FY-1940 7-12-40 76.50 B/L #1087.Memo.voucher,Transportation of remains (T.L.Schmidt). 7-15-40 726.13 S.D. Requisition No.1-41. Classes 6 & 8. 7-15-40 90.00 Pay Roll, 7-1 to 7-15, inclusive 7-15-40 35.00 PV#2-1. Embalming and encasement of T.L. Schmidt 7-31-40 $12.00 Stub Summary.July,Stationery.15.70. Gasoline,$6.30 7-31-40 20,00 Public Voucher No.1-1. Special diets, July. 7-31-40 22.00 Public Voucher No.1-2. Laundry services, July. 7-31-40 90.00 Pay Roll. 7-15 to 7-31, inclusive 8-3-40 6.00 Transfer Voucher Received No.2-41.Sugar from Naval Hospital .Wash. .D.C. 8-5-40 296.18 S.D. Requisition No.2-41. Classes 1. 2 and 11. 8-10-40 35.00 PV#3-1 (NHF) .Hospitalization of D.E.Fox in Memorial Hospital. 8-15-40 90.00 Pay Roll, 8-1 to 8-15, inclusive 8-20-40 18.30 S.D.Reqn.#16-40.Class IS.Reported on supplementary Form B, F.Y.1940, 8-31-40 11.50 Stub Summary. August.'Cleaning gear,#1,50.Gas.,Oil k Grease ,$10.00. 8-31-40 1.75 A.P.A.Stub Summary ,Aug. Pyrex ,1ar for Laboratory .No allotment charge. 8-31-40 10.00 T.V.R.No.3-41.Laundry services from NH,Washington,D.C. (August) 8-31-40 90.00 Pay Roll, 8-16 to 8-31, inclusive 9-2-40 $18.60 Drugs and Dental supplies purchased during July and August. 9-15-40 90.00 Pay Roll, 9-1 to 9-15, inclusive 9-20-40 178.60 S.D. Requisition No, 3-41. Classes 10,13,17 and 23. 9-30-40 19.25 Public Voucher No.1-4. Special Diets, September. 9-30-40 90.00 Pay Roll, 9-16 to 9-30, inclusive. 9-30-40 22.30 S&A Form 280,September.Work Request #37-41.Painting of ambulance. 9-30-40 12.80 Stub Summary,September.Gas..Oil & local minor repairs to ambulance. 9-30-40 10.00 T.V.R.#4-41.Laundry services from NH.Washington, D.C. (September) Totals 1,219.21 58.60 236.35 540.00 26.00 1.75 FIRST QUARTER TOTALS. F.T. 1941. 1 18 19 20 21 23 24 Lines on which reported on NMS Form "E". "NOTES: 3) Always taken up In supplies ledger by individual items. 5) Maintain one ledger sheet for salaries end one for wages. *) Maintain at least one ledger sheet for each expenditure classification as shown in the expenditure section, end in addition, one sheet for civilian medical, dental, nursing and hospital services. Additional sheets should be maintained under each expenditure class!fleation as may be necessary for adequate analysis. $) Stationery and Drugs taken up In supplies ledger by individual items. JOURNAL OF RECEIPTS AND EXPENDITURES OF MEDICAL DEPARTMENT PROPERTY FISCAL YEAR, 1941 HOSPITAL AND PROPERTY ACCOUNTABILITY 795 EXPENDITURES Tii—rri (•) (•) (*) (4) (4) (*) (*) (*)(4) (4) (4) (4) SUPPLIES SECTION Date Supply- Table , Medical Supply Table, Dental Special Diets leundiy Trans- port- ation Wise. Dental Supplies Mi sc. M.D.‘ Supplies Salaries Wages Care of the Dead Survey of Supplies T.V.I. to Supply Officer TVl.to other U.D. Aclivltfes Remarks 7-5-40 10.00 Special Diets. June. 1940 7-8-40 71.50 6.75 09.00 issue Voucher 7-18-40 “76.50 Issue Voucher(Trans.remains-T.L.Schmidt) 7-15-40 76.00 13.50 Issue Voucher 7-15-40 60.00 30.00 Pay Roll,7-1 to 7-15, inclusive 7-15-40 *35.00 Embalming 4 encasement (T.L.Schmidt) 7-82-40 63.00 11.15 02.15 01.50 Issue Vouchers 7-29-40 75.00 12.20 01.13 01.17 Issue Vouchers 7-31-40 20.00 22. 0C 6.30 Spec.Diets.Laundry.Gasoline lJuly) 7-31-40 60.00 30.00 Pay Roll, 7-16 to 7-31, inclusive 8-5-40 74.13 5.76 011.00 Issue Vouchers 3-10-40 *35.00 Uospitalization,D.E.Fox(Hemorial Hospital) 3-12-40 62.15 12.70 Issue Vouchers B-15-40 60.00 30.00 Pay Roll, 8-1 to 8-15, inclusive 3-19-40 72.32 13.02 02.15 Issue Vouchers 3-26-40 70.15 12.34 02.16 Issue Vouchers 3-31-40 10.00 Gas..Oil,Grease (August) 3-31-40 10.0C Laundry Services, August. T.V.R.#3-41 3-31-40 60.00 30.00 Pay Roll, 8-16 to 8-31, inclusive 9-2-40 56.70 13.15 #11.52 Issue Vouchers 9-9-40 72.18 11.12 .27 2.18 Issue Vouchers 9-15-40 60.00 30.00 Pay Roll, 9-1 to 9-15, inclusive 9-16-40 62.76] 2.01 .32 Issue Vouchers 9-23-40 51.11 10.57 Issue Vouchers 9-30-40 19.25 Special Diets, September 9-30-4C 82.76 13.07 2.16 3.65 Issue Voucher 9-30-4C 12.80 Gas.,Oil 4 minor repairs to ambulance 9-30-40 60.00 30.OC Pay Roll, 9-16 to 9-30, inclusive 9-30-40 125.00 Casket,N.S. (H.B.Smith) Local Burial 9-30-40 1.00 Drugs to U.S.S. KANE. T.V.I. #4-41 9-30-40 22.3C Painting of ambulance. Work Request #37-41 9-30-40 10.00 Laundry Services, September. T.V.R. #4-41 Totals 889.76 137.34 49.25 42.0C 51.4C 8.19 77.17 360,00 180.OC 236.50 1.00 FIRST QUARTER TOTALS. F.Y. 1941 28 29 30 31 32 33 34 35 36 38 40 41 42 Lines on which reported on NMS Form "E" NOTES:(4) Charge off individual items in supplies lodger. (*) Maintain one ledger sheet in supplies ledger for each classification so marked. I®; Miscellaneous supollea expended which were purchased during previous quarters. Iff) Issue Voucher for $11,52 includes $1.50 for cleaning gear and #10,02 for drugs consumed (issued) upon receipt. JOURNAL OF RECEIPTS AMD EXPENDITURES OF MEDICAL DEPARTMENT PROPERTY FISCAL YEAR. 1941 154294°—39 51 796 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY STATEMENT OF RECEIPTS AND EXPENDITURES OF MEDICAL DEPARTMENT PROPERTY U. S. ...(Name., of Station) For Quarter Ended .. , 1940 EQUIPMENT (NONEXPENDABLE) ~~ ===== 1. Balance from previous quarter (line 16, last report) $ 12,934*89 RECEIPTS DURING QUARTER 2. From Medical Supply Depots (charged to S. D. allotment) $ 3. From Supply Officer, stub requisition and expendi- ture invoices $ 9.7.?50 4. Public Vouchers (M. & S. Reqn. only) 50 5.00 5. Total (lines 3 and 4) (charged to local pro- curement allotments) TRANSFER VOUCHERS RECEIVED DURING QUARTER 6. From other Medical Department activities (S. & A. Form 71) *9.9 7. From Supply Officer, A. P. A. material, no allot- ment charge 99*99 8. Total (lines 6 and 7) 130 *99 9. Total receipts during quarter (lines 2, 5, and 8) 1 ».§4*5.61 10. Total (line 1 plus line 9) .ou EXPENDITURES 11. By approved survey (Equipment only) 4j.5j?P*QQ 12. By transfer to Supply Officer for sale 7.?..*.P9 13. By transfer to other Medical Department activities .(S. & A. Form 71) .. 60.00 14. Total (line 12 plus 13). 155*00 15. Total expenditures (line 11 plus line 14) J i 16. Balance to next quarter (line 10 less line 15) $ SUPPLIES (EXPENDABLE) 17. Balance from previous quarter (line 45, last report) $.....?.».§.§?.i38.«« RECEIPTS DURING QUARTER 18. From Medical Supply Depots (charged to S. D. allotment), $ 19. From Supply Officer stub requisitions and expendi- ture invoices $ 58 *60 20. Public Vouchers (M. & S. Reqn. only) 236,55 21. From pay rolls, civil employees 540 ,00 22. Total (lines 19, 20, and 21) (charged to local procurement allotments) * TRANSFER VOUCHERS RECEIVED DURING QUARTER 23. From other Medical Department activities (S. & A. Form 71) — — 2§«00 24. From Supply Officer, A. P. A. material, no allot- ment charge - X*?5 25. Total (lines 23 and 24) 27.75. 26. Total receipts during quarter (lines 18, 22, and 25) .. 2»081.91 27. Total (line 17 plus line 26) EXPENDITURES 28. Supply table supplies, medical, expended from storeroom 29. Supply table supplies, dental, expended from storeroom -X?.7.*34. 30. Special diets .49.*25 31. Laundry .. „ 4£*00 32. Transportation service .51*40 33. Miscellaneous supplies; dental (other than supply table) 34. Miscellaneous supplies; other (other than supply table) — .... 35. Salaries $ .. 360 *00. 36. Wages .180*00. 37. Total (lines 35 and 36) 540*00'.. 38. Care of the dead 236,50 39. Total (lines 30, 31, 32, 33, 34, 37, and 38 - .1.PP4.53,— 40. By approved survey (supplies only) ..P..*.PP 41. By transfer to Supply Officer (when authorized) Q.*.Q0. 42. By transfer to other Medical Department activities (S. & A. Form 71) IsQQ 43. Total (line 41 plus line 42) -*-99 44. Total expenditures (lines 28, 29, 39, 40, and 43) - ... . 45. Balance to next quarter (line 27 less line 44)^I11..I..:^.i:::.::i::li:::i^^ OPERATING EXPENSE 46. Gross expenditures (line 15 plus line 44) $...5.1.557 • 61 47. Less nonoperating expenditures (lines 14, 38, and 43) 572*50 48. Net operating expense - $ . 5,185,11 COMPLEMENT (INCLUDES ALL UNITS) 49. Average active-duty service personnel during quarter - ~ .1*7X3 50. Average number of civil employees at station during quarter - &7P 61. Average service and civil personnel during quarter MEDICAL SERVICES RENDERED CIVILIANS Number of individuals Number of treatments 52. Civil employees - X»Q.?.£...*. 53. Dependents .. — 1 ,.9.6.1 64. Civilians, other (humanitarian) 3 SLa 55. Totals ....5S4. 3.f.Q58 The respective values stated herein as on hand (lines 16 and 45) at the close of the quarter have veri- fied by actual inventory. The balances of the equipment and supplies ledgers agree with the respective values 6tated' A. B. CAST, Commander (MC) , U. S. N. Forwarded ; liiiSiSter) tr. s. N. Commanding. a/WBSfl*J HOSPITAL AND PROPERTY ACCOUNTABILITY 797 (1) Analysis of Supply Depot Requisitions Received During Quarter: Requisition Mo. Date Received Equltment Supplies Total S.D.14-40 7-2-40 $ 18.16 $ 0.00 $ 18.16 S.D. 16-40 8-20-40 0.00 18.30 18.30 S.D. 1-41 7-15-40 87.15 726.13 813.28 S.D. 2-41 8-5-40 0.00 296.18 296.18 S.D. 3-41 9-20-40 0.00 178.60 178.60 S. 15-41 8-2-40 5.00 0.00 6.00 Totals. $ 111.31 $ 1.219.21 $ 1.350.52 (2) Analysis of Stub Requisitions and Expenditure Invoices (Priced) Received During Quarter; Month Equipment Supplies Total July $ 0.00 $ 12.00 $ 12.00 August 35.00 11.50 45.50 September 62.30 35.10 %7.40 Totals. $ 97.30 $ 58.60 $ 155.90 (8) Summary of Public Vouchers Paid, Drawn Against M. & S. Requisitions; Annual Requisition .Vo. Equipment Supplies Total 1-40 {P.V.#1-12) $ 0.00 $ 10.00 $ 10.00 1- (P.V.#1-1 to 1-4,ine.) 0.00 79.85 79.85 2- (P.V.#2-1) 0.00 35.00 35.00 3- (P.V,#3-1) 0.00 35.00 35.00 Other than annual requisitions, 8t88 1,218:88 B/L #1087 (C/Pi 0.00 76.50 76.50 Totals. $ 1.305.00 $ 236.35 $ 1.541.35 (4) Analysis of Transfer Vouchers Received from Other Medical Department Activities During Quarter; T. V. R. No. Received from Equipment Supplies Total 1- USNH,Great Lakes,111. $ 100,00 $ 0,00 $ 100.00 2- USNH,Washington, D.C. 0.00 6.00 6.00 3- USNH,Washington, D.C. 0.00 10.00 10.00 4- USNH,Washington, D.C. 0.00 10.00 10.00 Totals. $ 100.00 $ 26.00 $ 126.00 (5) Analysis of A. P, A. Material Received from Supply Officer During Quarter: Month Equipment Supplies Total July 0.00 $ 0.00 $ 0.00 August 15.00 1.75 16.75 September 15.00 0.00 15.00 Totals, t 30.00 $ 1.75 $ $1.75 (6) Analysis of Approved Surry* During Quarter: Dote approved Value expended Value to B. O. Total value Survey No. Vy Bureau hy survey for sale Value to M. 8. D. of survey 6-40 6-3-40 « 1,340.00 $ 50.00 $ 0.00 $ 1,390.00 1-41 6-20-40 50.00 15.00 0.00 65.00 Totals, $ 1.390.00 $ 65.00 » 0.00 $ 1.455.00 (T) Analysis of Transfer Vouchers Issued During Quarter; T. T.t.So. IsineS ta Authority for Issue Equipment Supplies Total 12-40 NAS,San Diego, BuMtcS ltr.(Ll-$ * $ California PA) of 5-9-40. 60.00 0.00 60.00 1- Supply Officer App.Survey #1-41 15.00 0.00 15.00 2- Supply Officer App.Survey #8-40 10.00 0.00 10.00 3- Supply Officer App.Survey #6-40 50.00 0.00 50.00 4- U.3.S. BANS Bul&S Itr.(U-PA) 0.00 1.00 1.00 Totals. ef 9-g5-40 j 1SS'.M $ 1.00 $ (8) Analysis of Pay Rolls: Accrued and unpaid Accrued current Paid during Accrued and unpaid Month from previous month month month at end of month July $ 0.00 $ 180.00 $ 180.00 I 0.00 August 0.00 180.00 180.00 0.00 September 0.00 180.00 180.00 0.00 Totals. ~ 0.00 * 540.00 $ 540.00 0.00 Remarks: Eatimted cost of Supply Table supplies consumed in the treatment of dependents of Naval Personnel 1216.00. 798 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY SUPPLEMENTARY REPORT OF ALLOTMENT EXPENDITURES AND OBLIGATIONS HUH From: U. S. EK ENDED Sl.JCuly> 0S»e..pf.;fi5.tiYltyi Date.X. Augus.t..l9.40._ Table 1. STATUS OF ALLOTMENTS Medical Depart- (1) Naval Hospital Fund (2) Care or the Dead (3) Supply Depot (4) 2719 None. 3362 1961 2. Annual allotment—plus increases, less decreases 3. Expenditures previously reported X X X X X X X X X X X X X X $ Q*00 X X X X X X X X X X X X X X $....LTQne X X XX XXX X X X X X X X $ None $-....40.*7.5.. -Qa.0.0.. X X X X X X X X X X X X X X $....ACU7.5...... 5. Obligations brought forwar 6. Total Amount A\j d 11.00 None None ILABLE S 11.0Q $....None $ None $...1Q»QQ .Final S.—Hone S 1R.16 ?.n,7R l.QQ Hone .... None 1.84 10. Total (to agree with line 6) $ 11.00 $... Ilona $ Hone $ .40.75 Table 2. ANALYSIS OP COMPLETED TRANSACTIONS Medical Department Naval Hospital Fund Care or the Dead Provisions Maintenance 1. NS A material (summary 2. Work requests (supply offi 3. Annual req. No.lr4D(PV $ $ $ ft cer’s S&A 280 only 1 ) —.10...0.0. to PV# inclusive).. 8. Provision contracts... (PV 9. Other charges (list separat (I) ely): (2) (S) (4) (5) (6) (7) (8) (9) — (W) an $ 10.00 Table 3. ANALYSIS OP SUPPLY DEPOT REQUISITIONS (A) Supply Depot Requisitions Received During Current Quarter (B) Requisitions Submitted (Material Not Received) Number Date received Amount Number Dated Estimated cost 5.,E*..14-4Q. .7-JS.-4.0. $....18*16 5?Tn,. 16-40 .4-28-40..... Total... $....12*16 Total... $ 20,75 4—8008 HOSPITAL AND PROPERTY ACCOUNTABILITY 799 ANALYSIS OF ALLOTMENT EXPENDITURES Table 4. BY OBJECTS AND SUBHEADS Table 5. by classes and subheads MD Allotment no. ...37.12 Fiscal year 19.4.0 (2) NHF Allotment C/D Allotment (A) SUPPLIES SD Allotment No Object and Subhead (1) No Fiscal year 19.... (3) No Fiscal year 19 (4) S. T. class Amount Subhead totals 1413. IQ.,.0.0. Q.QQ Q.QQ ilml ...Q.QQ s ,c.Q0 Q.QQ 8 Q.Q0 Q.QQ 0.00 Q.QQ Q.QQ Q.QQ,... 0.00 Q.QQ Q.QQ Q.QQ 27 .Q.QQ 0.00 17 .Q.QQ 30 .Q.QQ c C C .Q.QQ O.QQ (B) EQUIPMENT s IB.16 0,00 0.00 0.00 OtOO O.JDlQ Totals... 10.00 0,00 0.0,0 24 0.00 0.00 Hii ,.m $ 10.00 $ 0.00 $ 0.00 16 J0..Q0. Fimhfintrnt' 0.00 0.00 0.00 Subhead 72.... 0.00 0.00 0.00 28 a.oa Totals... $ 10.00 $ 0.00 $ O.oo Subhead 74.... Q.QQ Remarks: Total Equipment $. ,13.16 (C) mortuary supplies and equipment S $ .0,,0.0... 0.00 Total PLIES Mortuary Sup- and Equipment... $ 0.00 (D) RECAPITULATION $ 0,00 18,16 A..J3...CAST* 0,00 Commander, Medical Corps , U. S. Navy. Total Receipts s.. .18,16 «. t. GOVERNMENT MINTING CMC 4—8002 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY soo FINAL supplementary REPORT OF ALLOTMENT EXPENDITURES AND OBLIGATIONS MONTH (raxmSK ENDED .31. August. 1940. FROM: U. S. LKama of nctivltv 1 Date 20 August 1940 Table 1. status of allotments Medical Depart- ment (1) Naval Hospital Fond (2) Care or the Dead (3) Supply Depot (4) 2719 None 3362 1961 $ 20.75 0.00 s s $ 6. Total Amount Available $ Mods $ None s ..None S 20.75 v - $ $ $...ia»2Q... .Final 2.45 10. Total (to agree with line 6) $ None s Nona None. $ 20.75 Table 2. ANALYSIS OF COMPL Medical Naval Hospital Fund Care or ETED TRANSACTIONS Department Provisions Maintenance the Dead $ $ $ 4. Annual req. No (PV# to PV# ft Annual rnq No. (PV# .. fo PV# - 9. Other charges (list separately): (2) (S) (^) (^) (7) - . .. /p) [10) . (.11) 10. Totals $ None S....Hone $ Hone $....Hone. Table 3. ANALYSIS OF SUPPLY DEPOT REQUISITIONS Number Date received Amount Number Dated Estimated coat a.D....i6.-40. .....8-8Q-4Q $ aa.59 None Total... $ 1.8. *.50. Total... $ Hone HOSPITAL AND PROPERTY ACCOUNTABILITY 801 Table 4. BV OBJECTS AND SUBHEADS Table 5. BY CLASSES and subheads MD Allotment NHF Allotment C/D Allotment (A) SUPPLIES SD Allotment No Object and No Subhead Fiscal year 19.... Fiscal year 19 Fiscal year 19.... S. T. class Amount Subhead totals (1) (2) (3) (4) 1 $ P.OQ 2 Q.QQ Q.OQ 4 QxQQ $ 0.00.. . 6 0*00 8 0*00 13 13.30 18.30 Q.QQ Q.QQ Q.QQ 0.00 23 Q.QQ Q.QQ Q.QQ Q.QQ 0.00 Q.QQ Q.QQ Q.QQ. . Q.QQ Q.QQ. .Q.QQ Q.QQ $ 18.2Q 0.00 0.00 0.00 0.00 0.00 s 0.00 0.00 Totals... Kone None Eone Q.,.0.0. RECAPITULATION 26 Q-.-0-0. 0.00 16 .0.0.0. Subhead 72.... .o.oo 28 .0.0.0. Totals... S.Ji'sne *..:;pne $ i.’oce Subhead 74.... 0.00 Total Equipment $ -0..Q0- (C) MORTUARY SUPPLIES AND EQUIPMENT $ 0.00 $ 0,00.... 21 0,00 Q.QQ Total Mortuary Sup- plies and Equipment... $ 0.00 (D) RECAPITULATION $ 18.30 ... .0..QQ . A. B—.CAST- .. 0*00 Commander, medical Corps, u- s- Na< Scrambled eggs 203 Mashed potatoes 200 American cheese 100 ■*< Hot rolls and butter 260 Sage dressing 200 Sliced pineapple 100 g Coffee Cranberry sauce, Celery and olives ,,. 100 50 Raisin loaf cake ... Bread and butter, ... 150 260 £ 740 Vanilla ice cream 200 Cocoa 250 Bread, butter, coffee 260 1,210 1,385 825 COMMISSARY SUPERVISION When the caloric values are totaled by days, allowing 600 calories each day for incidental articles of food used in cooking and flavoring, such as sugar and milk in the coffee and tea, flour and cornstarch used by the cooks as “thickening,” etc., it will be found that the menu given will total as follows: Monday 1 3, 735 Tuesday 3, 790 Wednesday 3, 270 Thursday 3, 270 Friday 3, 980 Saturday 3, 190 Sunday ' 3, 953 Average for 1 day 3, 598 In order to show the approximate amounts of the various nonstock items to order for a menu, the following list is suggested, based on a complement of 400 rations: Amount: Delivery day 600 pounds beef in sides (2 sides) Monday. 300 pounds loins of beef Monday. 300 pounds loins of pork Saturday before. 250 pounds of fowl, dressed and drawn Wednesday. 300 pounds of chicken, dressed and drawn Saturday. 400 pounds of lamb, carcasses Tuesday. 150 pounds salmon Thursday. 10 gallons clams Friday, a. m. 10 gallons oysters Tuesday, a. m. 40 pounds codfish, shredded Friday. 150 pounds pumpkins Saturday before. 5 pounds mint Tuesday. 200 pounds squash Wednesday. 150 pounds turnips Friday. 60 pounds cake Saturday. No estimates will be given for the remaining items of food on the menu, as they all are items which should be carried as stock items, and sufficient amounts of them should be in store at all times to meet ordinary demands. The two sides of beef should be cut up and used as follows; 2 rounds .1 2 sirloin butts 2 chucks 2 shoulder clods j Use as pot roast for Saturday dinner. 2 loins . Use as beefsteaks for Tuesday dinner. 2 eight-rib cuts Use as cold sliced meats for Tuesday supper. The briskets, cross ribs, plates, navels, rumps, and flanks remaining can be used as hamburger steak on Monday. The two loins of beef trimmed out of the two sides may be added to the 300 pounds of loins ordered for Monday and cut up into steaks for the Tuesday dinner. The lamb carcasses should be cut up into legs, shoulders, racks, and loins. The legs and shoulders to be used as roast lamb for Wednesday and the loins and racks saved for issue to the special diets as lamb chops. There will be sufficient meats left over during the week to provide left-over meats from which to make the croquettes Wednesday and fresh-meat hash on Friday. An important measure in the economical use of provisions is the proper cut- ting of meats. The description of meat cutting which follows is based on the instructions contained in the Navy training course for preparation for the rating of chief commissary steward. Meat Cutting.—The fore quarter of beef consists of six major parts, namely : Prime ribs, chuck, plate, brisket, foreshank, and neck. Before dividing a fore quarter of beef the meat cutter removes the skirt steak by cutting at either end, pulling the steak toward him and keeping the knife close to the ribs as he cuts. 826 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Dividing fore quarter.—First separate the fore quarter into two parts, one consisting of the prime ribs and chuck and the other consisting of the plate, brisl&t, shoulder clod, and shank. This cut is a long one, extending from the BEEF CHART WHOLESALE AND RETAIL CUTS (T) HIND SHANK I TO 3 SOUP BONES 4-HOCK Z ROUND ITO 14 ROUND STEAKS 15 HEEL OF ROUND 3 RUMP STEAKS on ROASTS 4 LOIN END I TO 6 SIRLOIN STEAKS 6 FLANK 1- STEAK 2- OR HAMBURGER 5 SHORT LOIN Ito3 CLUB or OELMONICO STEAKS 4 to M PORTERHOUSE STEAKS 12 PLATE I -STEWS OR BONED AND ROLLED ROASTS 2-SHORT RIBS 7 RIB I TO 4 RIB ROASTS 5 SHORT RIBS II BRISKET I-STEW'S OR BONED AND ROLLED ROASTS 8 TRIMMED CHUCK I * 2 BOTTOM CHUCK ROASTS 3 & 4 TOP CHUCK ROASTS 5to7 CHUCK RI8 ROASTS 10 FORE SHANK I TO3 SOUP BONES 4-SHOULDER CLOD (9) NECK (-BONELESS ROASTS STEWS on HAMBURGER Numerals m circles Q refer to wholesale cuts and major subdivisions of such cuts. Other numero/s refer to retail cuts WHOLESALE CUTS AND SUBDIVISIONS ALL PERCENTAGES BASED ON CARCASS WEIGHT TIE UP ARTERIES AND SEW UP INCISIONS IN SKIN. AMOUNT OF FLUJD TO USE 15 V. OF BODY WEIGHT. 2 V. IN EACH FEMORAL ARTERY. 1 % IN EACH BRACHIAL ARTERY. 2 7o IN ONE CAROTID ARTERY TOWARD HEAD. 7V. IN SAME CAROTID ARTERY TOWARD HEART. INJECT THORAX UNTIL SLIGHT EPIGASTRIC FULLNESS IS APPARENT. INJECT ABDOMEN UNTIL SLIGHT DISTENTION IS apparent, * Figure 166. EMBALMING 885 (c) When the carotids are being injected, massage of the face and adjacent parts is important, it being especially necessary to make sure that the fluid reaches less vascular parts, such as the tip of the nose and margins of the ears. Here, as elsewhere, palpable firmness of the tissues is the indication of success- ful injection. If any of these parts remain soft after completion of the arterial injection and show signs of “skin slipping,” fluid should be introduced by means of a hypodermic syringe, the point of the needle being inserted through the ear, hair line, nostril, or mouth, so that the puncture will not be noticeable. When, as sometimes happens, it is impossible to attain uniform firmness at the first injection, a second injection undertaken the next day often reaches the soft areas. Cavity injection. Besides injection of the arterial system, cavity injection should be performed, as much additional fluid being used for this purpose as may be required. When circumstances permit delay, it is well to postpone cavity injection until several hours have elapsed after the arterial injection has been completed. By that time, if a second arterial injection is to be required, the necessity for it will be apparent, and it can be undertaken before the breaks in the arterial system resulting from cavity injection are made. (a) Thorax.—By means of aspiration at several points remove all body fluids and inject each pleural cavity with embalming fluid under moderate pressure until a slight epigastric fullness becomes apparent. (ft) Abdomen.—By means of aspiration, the point of the needle being ex- tensively moved about, remove as far as possible all gas, liquid intestinal contents, and pathological fluids. Then inject embalming fluid, again moving the needle point about extensively, until slight distention is apparent. Kneading of the abdomen favors diffusion of the fluid. General instructions. (a) After autopsy bodies are to be embalmed in the same way; but in such cases the cavities of the abdomen, chest, and skull, after complete removal of all viscera, shall be packed with absorbent cotton saturated with embalming fluid, or a hardening compound composed of equal parts by weight of flake camphor or naphthalene, plaster of Paris, and dry sawdust may be used. Especial care must be exercised that the evidences of autopsy shall not cause unnecessary distress to relatives. To that end all wounds that have been made shall be neatly closed, if the brain has been examined the skullcap shall be secured to prevent its slipping, and packings and dressings used shall be clean and of suitable material. (ft) If fluid cannot be forced into an artery because of clots or other reasons, such as mutilation or advanced decomposition, multiple injections may be made into the tissues, which then should be wrapped in cotton saturated in embalm- ing fluid. In such case, further, the anus, mouth, and nostrils should be plugged with cotton soaked in embalming fluid, and the entire body, including the face, ears, and hair, washed with the fluid. (c) In the case of a body dead of smallpox, plague, Asiatic cholera, typhus fever, diphtheria, or scarlet fever, the remains, after being washed and after completion of the embalming, shall be bandaged completely, excepting the head, with muslin soaked in embalming fluid. The hands and face shall be enveloped in a suitable cloth saturated with embalming fluid. The laws of some States require that in such cases all body orifices be plugged with cotton soaked in 1-500 solution of mercury bichloride and the body wrapped in cloths saturated with 1-1,000 solution of mercury bichloride. 886 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Embalming fluid. (a) The formula for the embalming fluid to be used is given herewith. Liquid formaldehyde (U. S. P. solution of formaldehyde) cc— 13.5 Sodium borate (borax) grams— 5.0 Glycerin (optional) cc__ 5.0 Water, sufficient to make cc— 100. 0 Should the solution of formaldehyde contain less than 37 per cent of formal- dehyde gas, the amount used should be increased proportionately. The addition of ethyl alcohol in the proportion of 10 per cent of the amount of the liquids in this formula aids in the solution of the sodium borate and to some extent in preventing “graying” of the skin. (ft) As this solution is irritating to many skins, some form of protection is advisable. Gloves may be worn in special cases, but in general it will be found more convenient and equally safe to anoint the hands prior to beginning work with a heavy protective ointment. (c) The exact composition of an embalming fluid is of less importance than the method of injecting it, but service embalmers, who may be acquainted with civilian practice and inclined to follow it, should remember that methods which have proved equal to preserving remains for a few days in temperate regions may be entirely inadequate to preserve bodies for months in the tropics. The fluid represented by the formula quoted (Francis) will retain its stability for more than 2% years; it has proved effective in preserving human subjects ex- posed for 2 months to a temperature of 98° F.; and the property of formal- dehyde in acid solution of bleaching muscular tissue to an ashy gray is over- come by the addition of borax, which furnishes the desired alkalinity without causing deterioration of the solution. This formula is to be used, therefore, in all cases. (d) The fluid hardens tissues so rapidly that thorough penetration to more remote parts often is hindered. For this reason the whole procedure should be carried out expeditiously, and it is recommended that at each site specified the injection be started with half-strength solution; when the return flow is estab- lished the full-strength solution then should be used as directed in this section. (e) The pressure essential to successful injection may be obtained either by elevating the container to a height of 6 feet or, in emergency, by means of a continuous flow rubber bulb syringe or a hard rubber pump syringe. The details requiring attention in employing either method will suggest themselves. It is necessary to state that if a pump is used, in order to avoid rupturing blood vessels, the pumping must he slow and no attempt made to force or hurry the flow of the embalming fluid. A slow penetration by gravity with a minimum of pressure gives better results and preserves the natural appearance much better. When an embalmed body is to be returned from foreign countries to the United States or must be retained on board ship for some time, especial care must be exercised to insure that it will be in good condition at the time of shipment and interment. To accomplish this an injection of one-fourth strength embalming fluid may first be made, followed 12 hours later by one-half strength and 36 hours after the first injection by one of full strength. In such cases the body should not be encased until sufficient time has elapsed after embalming for thorough evaporation of moisture to take place. After time for evaporation has been allowed, the entire body should be coated with vaseline or phenol ointment and wrapped, first with gauze, muslin, or surveyed linen and then with impervious waxed paper, the wrappings being secured in place by bandages. Before encasing the wrapped but unclothed body the casket should INDEPENDENT DUTY 887 be opened and exposed to the sun or artificial heat in order that the lining and padding may be free from moisture. Clothing for the body should be dried, wrapped in impervious waxed paper, and placed on top of the casket in the shipping box. References Manual of the Medical Department, U. S. Navy. Bureau of Medicine and Surgery circular letters. Section 8.—INDEPENDENT DUTY To carry out the duties with which it is charged in articles 457 and 458, Navy Regulations, the Bureau of Medicine and Surgery assigns chief pharmacist’s mates and pharmacist’s mates, first class, to duty as the representatives of the medical department on board small vessels and at small shore stations where the nature of the duty does not justify the assignment of medical officers. They are not offered as substitutes for qualified medical officers, but rather as first- aid men who are capable of relieving the commanding officer of most, if not all, of the detailed management of the sick and injured. Because of the training, instruction, and experience of men in the Hospital Corps, especially in the upper ratings, the Bureau of Medicine and Surgery believes that many times life or limb may be saved that might, without their intelligent first-aid, be jeopardized. The responsibilities of pharmacist’s mates on independent duty are similar to those of a medical officer, and the mission is the same. Pharmacist’s mates assigned to independent duty have demonstrated their qualifications for their rating by written and practical examinations and the Bureau of Medicine and Surgery feels that the commanding officers of vessels and shore stations to which no medical officer is attached, whose experience, general education, judg- ment, and mental training especially fit them for the assumption of responsi- bility in emergencies, ordinarily may rely on these men for valuable and trained assistance in first-aid work when more skilled medical services cannot be secured. Pharmacist’s mates assigned to duty independent of a medical officer and where medical officers are not available are cautioned to bear in mind the fact that the commanding officer of the ship or station is directly responsible for the proper care and disposition of the sick and injured. But it is a paramount duty of a hospital corpsman so situated to make recommendations to the com- manding officer regarding matters affecting the health of the crew, the disposi- tion of the injured, or any unusual condition requiring the services of a medical officer or qualified medical practitioner, temporary assistance for members of the crew, etc. There should be a definite time, approved by the commanding officer for sick call. Minor ailments and injuries are attended to at this time; arrangements for vaccination, visiting a medical officer, and excusing men from duty, but at any time the pharmacist’s mate should be ready to examine men who could not attend regular sick call or who have become ill or have been injured subsequently. Second only to the care of those actually sick or injured is the responsibility of independent-duty pharmacist’s mates with regard to the application of hygienic and sanitary measures. A daily inspection of the ship or station is necessary to accomplish this, and should not be made until after all cleaning stations have been policed. 888 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In making this daily inspection particular attention should be given to places where dirt can accumulate, such as corners, angle-irons, mess gear, mess and clothes lockers, fans, ventilators, blowers, ice boxes, vegetable lockers, wash bowls, urinals, drains, scuppers, and gratings—in fact, any place where an effort must be made to attain cleanliness. The condition of the cooking utensils, pots and pans, the galley range and the deck beneath it should be observed; the bottoms of mess tables and bunks, especially the bunk frames, should be inspected; in storerooms the stowage of unauthorized articles, such as wash buckets, swabs, dirty or wet clothes, should not be permitted, and one should be sure that the bilges of storerooms aboard ship are dry and clean. Ashore, in addition to the above, care must be exercised in the disposal of waste and garbage, the accumulation of stagnant water, drainage, protection of water containers, removal of undergrowth, manure, leaves, etc., cutting weeds and long grass, and the methods used in the disposal of human excreta. ' In short, it is most important that the pharmacist’s mate on independent duty constantly be on the alert to observe anything and everything that in any way might be detrimental to the health and welfare of those with whom he is serving and who depend upon him for protection against disease. Dirt, filth, grease, and decayed or decaying matter are dangerous to health; all can be removed by the use of water, soap, kerosene, and “elbow grease”; and all can be prevented by careful observation and frequent inspection. In the absence of medical officers it devolves upon the pharmacist’s mate representing the medical department to inspect the food prepared for the crew, as to wholesomeness and cleanliness, the fruit and other articles of food and drink offered for sale by boats alongside, and all fresh provisions purchased for the general mess. After such inspections a report should be made to the proper officer as to the conditions found, with such recommendations as are con- sidered necessary. There should be no hesitancy in recommending rejection or refusal of permission to boats alongside to sell if the inspection shows them to be unsatisfactory. Instructions governing such inspections are contained in articles 1156, 1157, 1158, 1159, 1320(2), and 1324, Navy Regulations. On duty independent of a medical officer pharmacist’s mates primarily are expected to: (a) Care for the ordinary ailments of the crew of the vessel or station to which they are attached. (&) Administer first-aid to any serious case that may occur. (c) Maintain a sanitary supervision of the vessel or station, and make suit- able recommendations to the commanding officer. (d) Maintain a proper amount of medical supplies to meet ordinary condi- tions. (e) Prepare for forwarding the necessary forms of the Bureau of Medicine and Surgery and keep the required medical records. (/) Investigate the health conditions in ports visited or in adjacent cities and make a report to the commanding officer with such recommendations as may be indicated. Learn and comply with local quarantine regulations. Whenever contact with medical officers is possible, independent-duty phar- macist’s mates should visit them for council and advice. Frequent consultation with the commanding officer is desirable. They should inform him promptly of any suspected contagious or infectious disease that may appear, and when a patient is in need of the services of a doctor. They are expected at all times to be ready to exert themselves to the utmost to assist any person on board in need of assistance by reason of illness or injury, and, so far as may be prac- ticable, to segregate in the sick bay or other designated place any member of the 889 LABORATORY PROCEDURES AND TECHNIQUE crew who is on the sick list, and to calmly, quietly, and efficiently aid the commanding officer in the maintenance of the morale of the crew in the presence of disease or injury on board. Upon reporting for duty independent of a medical officer, pharmacist’s mates should, if practicable, communicate immediately with the medical officer having- supervision of the medical department of the vessel or station and inform themselves regarding the local organization and the arrangements for obtain- ing medical assistance when needed. They should accurately check the inven- tory of medical-department property (if possible with the man being relieved) and report any discrepancies to the commanding officer and medical officer. Do not accomplish a transfer of property unless prepared to assume responsi- bility for the property reported on the inventory. A pharmacist’s mate on inde- pendent duty has the same responsibility regarding care of property and submission of reports as a medical officer, and when selected for that duty it is assumed that his training and experience have been such that he can perform such duties and can be trusted with the care of medical-department property without immediate supervision. All health records should be examined and carefully checked for errors and omissions and to see that all members of the crew have been properly immunized against small pox and typhoid fever in accordance with current instructions. Any who have not should be immunized immediately for a single case of small pox or typhoid fever is evidence of gross negligence, particular on the part of the one having custody of the health record at that time. Attempt to locate any missing records and open new ones if necessary. The space and equipment for use by the representative of the medical de- partment in the care of the sick or injured should be clean and ready for use when the occasion demands. The question of “how far should I go in treating this case” will present itself time and again to the pharmacist’s mate on independent duty. It would be unwise to establish a rule or rules governing this, but it should never be for- gotten that the primary duty is to prevent disease, to prevent injuries, and to preserve life and limb of the person afflicted. The capable pharmacist’s mate will, considering all things and knowing his own ability, decide what is best for his patient, and the life of the patient often will depend upon this decision. Section 9.—LABORATORY PROCEDURES AND TECHNIQUE URINALYSIS AND BLOOD CHEMISTRY Urinalysis. Urine is an important and complex excretion formed in the kidneys. It carries in aqueous solution waste products arising from metabolism and prod- ucts which come directly from substances eaten. The normal constituents of the urine are divided into organic and inorganic groups. The important or- ganic constituents are urea, uric acid, and creatinine; those of the inorganic group are the chlorides, phosphates, sulfates, and ammonia. The normal urine may contain various cellular elements, such as epithelial cells and leucocytes, also a number of crystals which usually form on standing, and are recognized microscopically. Normal ubine as voided is light straw to dark amber in color, acid in reaction, and transparent. Usually the composition of the urine of a given individual, voided in a 24-hour period, does not vary much from day to day; specimens voided at different times in the day may, however, differ markedly. 890 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY In qualitative work random specimens may be examined, but a 24-hour speci- men is more desirable, and quantitative tests are valueless unless done on the mixed specimen for the 24-hour period. A 24-hour specimen of urine should be collected in a clean container and kept cold, preferably on ice, or protected by a suitable preservative, until examined. Toluene is the best preservative, as it interferes least with the tests which may be performed. One or two cubic centimeters placed in the container to be used for collection of specimen, suffice for this purpose. Thymol also may be used as a urinary preservative. Numerous other preservatives have been used but are less desirable as they may cause false positives or interfere with reactions. The use of preservatives should not be substituted for refrigeration, cleanliness, and care. Routine examination.—Urine for examination should be clear, and may be made so by simple filtration or by filtration after the urine has been mixed and shaken with a small amount of purified talc. When making a routine urine examination one should: 1. measure the amount.—The 24-hour specimen, normally, should be from 1,000 to 1,500 cc. This amount depends upon the balance between the quantity of fluids ingested and the fluids lost by other avenues—perspiration, respiration, faeces (as in diarrhoea), and vomitus. 2. note the color.—This varies in health and depends upon the concentra- tion. The presence of blood, bile, urobilin, and some drugs will affect the color. A pale urine of high specific gravity suggests the presence of sugar (diabetes). 3. note the transparency.-—Freshly passed urine is usually clear, but upon standing becomes cloudy. Large quantities of amorphous phosphates, amor- phous urates, pus, blood, and bacteria produce sediments or cloudy appearances. 4. note the odor.—An aromatic odor is due to volatile acids; ammoniacal to decomposition; fruity to acetone; and characteristic odors are produced by certain substances, as asparagus, etc. 5. test for reaction.—Acid urine turns blue litmus paper red; alkaline urine turns red litmus paper blue. If the urine is neutral in reaction, no apparent change is produced in the litmus papers. Normally urine is acid in reaction, but soon becomes alkaline upon standing when not refrigerated or preserved. 6. test to determine specifio gravity.—Normally this is 1.010 to 1.020. A urinometer is the most convenient means of determining the specific gravity of urine. A special container is filled with urine and a urinometer placed in the container. The urinometer should not touch the sides or bottom of the con- tainer and should be read at the bottom of the meniscus. The specific gravity of normal urine varies with the concentration. The sugar content of urine in diabetes causes a high specific gravity. 7. test for albumin using the heat and acetic acid test. Fill a clean test tube two-thirds full of clear urine. Filter, if necessary, to clear. Boil the upper portion. Add 3 to 10 drops of 10 per cent acetic acid to acidify and reboil. Compare boiled and unboiled portion and report the degree of turbidity of the coagulated albumin on the basis of 4 plus as a maximum. A turbidity in the boiled portion that clears with the acid is ordinarily due to carbonates or phosphates. Albuminuria is an abnormal condition indicating a leakage of blood- serum albumin into the urinary tract and requires further careful investigation. 8. test for glucose (sugar) by placing 5 cc of Benedict’s qualitative solu- tion in a test tube. Boil. Add 0.5 cc of urine. Boil 2 minutes and let cool. If glucose is present, the blue cupric salt will be reduced to a cuprous salt and the solution will be filled with a green, yellow, or red precipitate. Report on the basis of 4 plus as the maximum red precipitate. Benedict’s qualitative solu- tion for urine sugar test is prepared by dissolving 173 6m, of sodium citrate and 891 LABORATORY PROCEDURES AND TECHNIQUE 100 Gm. of anhydrous (or 200 Gm. of crystalline) sodium carbonate in 700 cc of hot water and filter. Add slowly, and with constant stirring, 17.3 Gm. of copper sulfate dissolved in about 100 cc water. Cool, and dilute to 1 liter. Benedict’s quantitative solution is used when required to calculate the amount of glucose present. (See any standard laboratory textbook for preparation of this solution and procedure). An occasional trace of sugar in the urine may be an unimportant finding and may occur following general anaesthesia, the administration of certain drugs, in pregnancy, in head injuries, or a meal heavy in carbohydrates. The finding of sugar, however, always warrants carefully repeated examination and, if persistent, carbohydrate tolerance should be tested, the basal metabolic rate ascertained, and the blood sugar content determined in an effort to establish the cause of this abnormal finding. 9. examine microscopically.—The uncentrifuged urine may be examined microscopically, especially if allowed to stand and some of the sediment taken up in a pipette, but it is usually preferable to centrifuge the urine and examine the sediment. The casts, pus cells, red blood cells, crystals, and other formed bodies, which may be present in a quantity of urine are, by centrifuging, concen- trated and more easily found. The sediment may be examined microscopically either uncovered or covered with a cover glass. In acid urine may be found uric-acid crystals, amorphous-urate deposits, calcium-oxalate 'crystals, and, rarely, leucin, tyrosin, and cystin crystals, and fat globules; in alkaline urine, amorphous phosphates, calcium-carbonate deposits, and ammonium-urate crystals. The following organized structures may be found in urinary sediments: Tube casts, epithelial cells, bacteria, red and white blood cells, spermatozoa, and animal parasites. Pus cells and red blood cells, when present, are reported as the number per high-power field in uncentrifuged urine, using a cover glass preparation. As the urine ages the casts and red blood cells decrease in number, also in alkaline urine. Special tests.—In addition to a routine urinalysis the abnormal constituents named hereafter may be present in the urine and require special tests to de- termine their presence. ketone bodies.—Acetone and diacetic acid are abnormal acid bodies formed in the acidosis of diabetes, in fevers, and in starvation. The importance of examining urines for ketone bodies, which have been found positive for sugar, should be emphasized. Diabetic patients are frequently first discovered in the coma of diabetic acidosis. This type of acidosis (ketonic) may also be a serious complication in the febrile diseases of childhood. bile.—Found in the urine in cases of jaundice. urobilin.—May be found in abnormal amount in conditions in which red blood cells are being destroyed rapidly, in cases of liver insufficiency, or liver infection. indioan.—Caused by the absorption of the products of protein decomposition. occult blood.—When the presence of blood is suspected but cannot be found by microscopic examination a chemical test may be used. Blood chemistry. The blood comes into intimate contact with all the tissues and carries nour- ishment to and waste materials away from them. It carries those products of the glands of Internal secretion which act as chemic excitants, stimulants, or regulators and are known as hormones. Insulin from the pancreas, thy- roxin from the thyroid, and epinephrine from the adrenals are examples of hormones. The blood carries oxygen to and carbon dioxide away from the 154204'’—39 57 892 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY tissues and is the vehicle through which the acid-base balance of the blood is so accurately regulated. The body is continually taking in acid and alkali sub- stances. Much acid is also formed in the body by normal oxidative processes. The sulfur and phosphorus of the proteins are oxidized to sulfuric and phos- phoric acids, and the carbon of the carbohydrates forms carbonic acid. The amount of acid formed, neutralized, and excreted in this way in 24 hours equals the acid contained in several hundred cubic centimeters of normal hydrochloric acid. How, then, is the reaction (hydrogen ion concentration or pH) of the blood maintained and regulated within the narrow limits neces- sary? This is accomplished by the so-called buffer substances of the body. A buffer in this connection, may be defined as a substance which has the prop- erty of stabilizing the reaction of a solution in which it is present; that is, it takes up the acid without appreciable change in its own reaction. When ex- cessive amounts of acid are formed the blood buffers—that is, the alkali re- serve—of the blood becomes dangerously lowered. Valuable and accurate clini- cal methods of measuring the alkali reserve and thus determining the degree of acidosis are the measurement of the carbon dioxide combining power of blood plasma and the carbon dioxide content of the alveolar air. The blood being in such constant and intimate contact with all the organs and tissues, changes in them or alterations of their function are often accu- rately mirrored by it. Changes in the chemistry of the blood occur as the result of conditions altering formation, utilization, or elimination of substances in the body. Examples of these are changes in the kidneys by which products normally excreted tend to be retained (urea, uric acid, creatinine), or metabolic diseases, such as diabetes, in which the formation of the internal secretion of the pancreas is diminished, and, as a result, the organism loses its power to properly utilize carbohydrates. Collection of blood.—For analysis blood is collected in the usual manner from a vein in the arm. Chemically clean and dry glassware must be used throughout. It is necessary in chemical work to prevent clotting of the blood. In order that this may be accomplished neutral potassium oxalate in the pro- portion of 2 milligrams for each cubic centimeter of blood is placed in the flask in which the blood Sample is to be collected. For a complete chemical analysis collect about 15 cc. An excess of the oxalate should be avoided, as large amounts may interfere seriously with analysis. A good plan is, where practicable, to obtain the small flasks for collection of the blood specimen directly from the laboratory where sufficient oxalate has already been added to prevent the coagulation of 10-15 cc of blood. Blood for tests is usually drawn before breakfast after an over-night fast. Certain procedures, such as calcium and phosphorus determinations, agglu- tination reactions, complement fixation tests, Kahn tests for syphilis, and serum colorimetric determinations require clear, nonhsemolized serum. The blood is therefore taken without the use of the oxalate anticoagulant, allowed to coagulate, and the serum separated. Special training is required to master the methods used in quantitative analysis of blood and urine. The technique will be found in detail in texts on laboratory procedures. Normal blood chemical standards per 100 cc are as follows: Cholesterol milligrams 140-200 Chlorides (as NaCl in whole blood) milligrams 450-500 Creatinine milligrams 1-2 Glucose — milligrams 80-120 Nonprotein Nitrogen————— milligrams— 25-35 LABORATORY PROCEDURES AND TECHNIQUE 893 Urea Nitrogen ; milligrams 12-18 Uric Acid milligrams 2-4 Total Protein grams 6-8.5 Albumin , grams 4.5-S.5 Globulin grams 1.5-3 Calcium milligrams— 9-11 Phosphorus milligrams 3-4.5 FUNCTIONAL TESTS Kidney function. The ability of the kidney to excrete substances from the blood stream is fre- quently affected by disease, especially such disease as disturbs the kidney, and is usually diminished after the age of 50 years. Disease of the kidney, how- ever, does not necessarily imply an inability to eliminate substances; that is to say, the functional lesion need not parallel the anatomical. Function, even when serious disease exists, may be normal, especially when the changes are of focal type. Moreover, impairment of renal function does not affect the excretion of different compounds to the same extent. It is well established that functions for chlorides and for urea are independent of each other. In any urine examination, then, one should restrict conclusions regarding im- pairment of excretory power to the substances under consideration. By com- bining the findings derived from blood chemistry and other tests of renal func- tion, one is in a position intelligently to adjust the diet, etc., to the excretory X>owers of the kidney, always bearing in mind, however, that the nutritive need of the body cannot be neglected. Many methods are employed for the determination of kidney function, and their relative values are still debatable. Their multiplicity indicates that no single test is entirely satisfactory, and one should always apply two or more to the case before forming a conclusion. Several kidney-function tests will next be described. Bloou Nitrogen Retention.—Of the nitrogenous constituents in the blood, the kidney excretes creatinine most readily, urea next, and uric acid with the most difficulty. As a consequence, an impairment of function usually results first in the retention of uric acid, then urea, and, finally, creatinine. Owing to the relatively small amount of uric acid and creatinine present, the nonprotein nitrogen, which includes the nitrogen in them as well as in other compounds, is affected very little by alterations in their amounts. The nonprotein nitrogen value is dependent chiefly upon the urea content. This fact is the basis of an intelligent interpretation of the findings. It is said that urea excretion is normal until three-fourths to six-sevenths of the total functional capacity of the kidneys is lost. Nonprotein nitrogen increases only when about 60 per cent has been lost, and retention is rare unless the phthalein excretion is less than 40 per cent for 2 hours. Hence, an increase in urea nitrogen or nonprotein nitrogen means bilaterally impaired function. It has been found that uric acid determination is of much assistance in judging the significance of occa- sional casts and traces of albumin in the urine, an increase speaking for an organic kidney lesion. On the usual hospital diet over 20 for urea nitrogen should be considered suggestive of impaired kidney function; over 70 speaks decisively for renal involvement and probable uraemia. Values for creatinine of over 4 do not occur without great impairment of renal function and probability of uraemia. Dilution Test.—1. Preparation of patient: The day before the test instruct the patient to consume at least 1,000 cc of liquids during the 24 hours and to follow his usual routine in regard to meals. This procedure precludes the test 894 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY being performed on an individual whose tissues have been deprived of fluid. 2. Day of test: At 8 a. m. instruct patient to empty his bladder (this urine to be discarded). 3. Patient to drink 1,500 cc of water within 15 minutes. 4. Omit breakfast. 5. Collect specimens of urine in separate containers at 8: 30, 9. 9:30, 10, 10:30, 11, 11:30 a. m., and 12 noon. Each specimen should be labeled with exact time of collection. The patient may receive his usual diet for luncheon and dinner. Test; 1. Measure the Quantity of urine obtained in each specimen. 2. Obtain the specific gravity of each specimen. Record as a curve. normal findings.—The total quantity voided up to 12 noon should be not less than 1,200 cc nor more than 1,800 cc. The specific gravity of at least one sample should be 1.003 or below. clinical significance.—This test determines the ability of the kidney to dilute urine and excrete water. Deviation from normal indicates impaired renal function. Concentration Test.—Preparation of patient: 1. Instruct patient to take no fluids after the evening meal the day before the test and no fluids at any time during the test and to strictly adhere to the dry diet. 2. At 8 a. m. on the day of the test instruct the patient to empty the bladder and discard urine. Sample diet for three meals on day of test: At 8 a. in., dry cereal with sugar, syrup, or honey; one egg; toast or bread with butter; no fluid. At 12 noon, roast beef, steak or chops; potatoes (boiled, baked, or riced) ; bread and butter; jam; no fluid. At 5 p. m., two eggs; bread and butter; jam; no fluid. collection of urine.—Collect urine in separate containers every three hours until 8 p. m. (11 a. m., 2 p. m., 5 p. m., and 8 p. m.). Samples should be labeled with the hour of collection. Collect night urine at 12 midnight and at 8 a. m. in separate containers. test.—Note the quantity and specific gravity of each sample. normal findings.—The specific gravity of one day sample should reach 1.025 or above. The specific gravity of one night specimen should reach 1.030 or above. clinical significance.—The finding of the specific gravity below 1.025 in all day specimens and below 1.030 in all night specimens indicates decreased renal efficiency. These two tests have repeatedly shown impaired kidney function before it could be demonstrated with other kidney function tests. Twenty-four hours should elapse between tests and both tests should be performed before reaching a conclusion as to renal efficiency. Mosenthal Test.—This test is generally spoken of as the two-hour test. Preparation of patient: 1. To receive the usual diet on the day of the test; also the day before the test. No food or drink is to be taken except at meals. 2. Patient to empty bladder immediately before breakfast (8 a. m.) on day of test (this to be discarded). 3. Collect specimens at 10 a. m,, 12 noon, 2 p. m., 4 p. m., 7 p. m., and 10 p. m. Each specimen to be collected in a separate container, properly labeled with the hour of collection. Note: The 10 p. m. specimen must not be collected less than 3 hours after the evening meal has begun. 4. Collect all urihe from 10 p. m. to 8 a. m. the following morning. This specimen to be in a separate container and labeled “8 a. m. specimen.” test.—1. Determine volume and specific gravity of each specimen passed during the day. 2. Measure the night urine (10 p. m. to 8 a. m.) and deter- mine the specific gravity. sources of error.—All samples not at the same temperature when specific gravity is taken. Erroneous figures will be obtained unless the samples are at the same temperature when specific gravity is obtained. LABORATORY PROCEDURES AND TECHNIQUE 895 normal findings.—1. Night urine will be less than one-half the quantity of total day urine (usually less than 500 ce). The normal ratio of day to night urine is not disturbed, the normal being 4-1 or 3-1. Night specimen should have a specific gravity of 1.018 or above. 2. One day specimen will usually have a specific gravity of 1.018 or above and 1 day sample will have a specific gravity 8 points lower than the highest specific gravity for the day specimen. Example: Highest specific gravity recorded for any single day sample 1.020; the most dilute will be 1.012 or less in normal findings. clinical significance.—1. Usually the first and most definite evidence of impaired kidney function is Indicated by an increase in the night urine, over 500 cc, and the normal ratio of day urine to night urine is disturbed. 2. The highest specific gravity of a day specimen falling below 1.018 is an indi- cation of impairment of renal function. 3. Fixation of specific gravity and an increase in the quantity of urine voided at night .(more than 500-700 ce) is definite indication of impaired renal function. By fixation of specific gravity is meant a variation between extremes of less than 0.008. Pool all specimens in one container and determine the 24-hour excretion of sodium chloride and nitrogen, Mosenthal states that the results obtained by dividing the urea value obtained by the hypobromite test by 2.14 (the nitrogen factor) is a sufficiently accurate expression of the total nitrogen value for the purposes of the test. A normal maximal specific gravity indicates that the kidney can concentrate the urine satisfactorily, providing the 24-hour amount of urine is adequate. A high specific gravity with oliguria (urine excretion deficiency) occurs only in passive congestion of the kidney, and in acute, subacute, or chronic diffuse nephritis, conditions that also show a markedly diminished sodium chloride excretion, together with considerable albuminuria and oedema. Long life is often possible, providing a low specific gravity is compensated by polyuria, (excessive urine secretion) as in diabetes insipidus, chronic nephritis, marked anaemia, during the elimination of oedema, cystitis, pyelitis, polycystic kidney, prostatic hypertrophy, urethral stricture, and paralysis of the bladder, such as occurs in tabes dorsalis, tumor of the cord, etc. Such cases may do well as long as there is a compensatory polyuria. A nocturnal polyuria indicates an overworked kidney and the strain may result in functional damage. Over 500 cc should be considered somewhat suspicious of renal insufficiency. In nephritis it may be improved by cur- tailing the food intake. Nycturia (nocturnal urinary incontinence), the result of prostatic or vesical irritation, should not be confused with nocturnal polyuria. Sodium chloride is being ingested in unnecessary amount if the 24-hour ex- cretion exceeds 5 Gm. A very low excretion, together with oedema, indicates an inadequate elimination, and is then not a criterion of the diet. If 5 or 6 Gm. of nitrogen are eliminated in the urine every 24 hours, there is sufficient protein in the food to maintain the individual’s health and strength, provided the diet contains a considerable amount of starch. Restric- tion of proteins should be guided by the nature of the disease. Thus the test supplies information useful in diagnosis, is an early index of renal function, and serves as a guide to diet. Phenolsulfonephthalein (phtiialein or red) Tbst.—This was developed by Rowntree and Geraghty, and its simplicity makes it very useful. It estimates only excretory ability at the moment for a foreign substance, is not considered quite as reliable as chemical analysis of the blood, and, of course, does not give HANDBOOK OE THE HOSPITAL, CORPS, U. S. NAVY the additional information that the latter sxipplies; also, in certain cases com- plete collection of urine sample may be difficult. It is, however, of much value, gives positive results before urea retention appears, has no contraindications, and does compare the kidneys and evaluate each when combined with ureteral catheterization or use of a separator. Diminished excretion of the dye occurs only when about 50 per cent of kidney function is lost. Positive results are of more significance than negative. Values of more than 75 per cent for 2 hours may be accompanied by diuresis, and Frank considers such a finding suggestive of renal disturbance with irritation if there is any corroborative evidence. The technique comprises administration of the dye, determination of the interval before it appears in the urine, and the amount then excreted during definite periods. The dye is employed in solution, and is conveniently pur- chased already sterilized in ampules, each containing slightly more than 1 cc of a solution of its monosodium salt of the strength of 6 mg. per cubic centimeter. The patient drinks 200-400 cc of water, and 20 minutes later 0 mg. of the dye is injected intramuscularly into the lumbar muscles or intra- venously. The bladder is immediately emptied and the urine discarded. The succeeding portions of urine may be collected by voiding, but it is more accu- rate to catheterize the bladder or ureters, and catheterization is practically a necessity for determination of the “appearance time.” The “appearance time” is the interval of time elapsing between injection of dye and its appearance in the urine. It is determined by allowing the urine to drip from the catheter into a receiver containing a drop of 10 per cent sodium hydroxide solution. The first traces of the dye will cause a pink color. The time interval chosen for calculating excretion is then computed from the instant of this appearance. There is considerable diversity in practice as re- gards this time interval, and it would seem that shorter intervals and quicker results are gaining in preference, as well as being considered equal in value to longer periods. The percentage excretion of the dye is now measured in each sample of the collected urine. One may employ the simple and inexpensive colorimeter of Dunning, but it is better to prepare a fresh standard, as the colors of such permanent ones tend to fade. It is also preferable to follow the suggestion of Cabot and use standards in test tubes rather than in the ordinary colorim- eter, because off colors frequently occxxr, and a satisfactory match of unknown and standard is then impossible in the latter instrument. Prepare a 100 per cent standard by diluting 1 cc of the phenolsulfoneph- thalein solution to 1,000 cc with water. Using test tubes and rack such as those for pH determinations, measure into the test tubes portions of this standard, each tube receiving 0.5 cc less than the preceeding one. A series from 6 to 1.5 cc is satisfactory and gives standards representing 60 per cent to 15 per cent with 5 per cent intervals. Add one drop of 10 per cent sodium hydroxide solution to each tube, fill to the 10 cc mark with water, and mix. Dilute the specimen of urine to some convenient volume that will permit a color match in the standard series and estimate its percentage strength, inter- polating if necessary. To calculate the per cent of dye excreted in the sample, multiply the determined percentage by the total volume to which it was diluted and divide by 1,000. After intravenous injection the appearance time is 4-6 minutes normally, and the normal elimination is 35-40 per cent in 15 minutes, 50-65 percent in 30 min- utes, and 65-80 per cent for 60 minutes, or for the first 30 minutes it may be stated as about 1 per cent per minute from each kidney. 897 LABORATORY PROCEDURES AND TECHNIQUE After intramuscular injection, the normal appearance time is nearer 10 minutes, and the normal elimination is 30-40 per cent in 30 minutes, about 50 per cent (40-60) for 60 minutes, and about 80 per cent (50-85) for 2 hours, or 20-25 per cent during the second hour. If the appearance time is not determined it is customary to allow for it, collecting the first hour’s specimen at 70 minutes after injection of dye and the second hour’s 60 minutes later. Impairment of kidney function, of course, increases appearance time and lessens excretion, serious cases not unusually excreting less than 1 per cent during two hours. When the question of the kidney involved arises, the urine must be taken by ureteral catheterization or by a separator. Urea Clearance Test.—Preparation of patient; Eats usual breakfast at 8 a. m. without tea or coffee, but water as desired. At 9 a. m. patient voids completely and urine is discarded. Give 100 cc water. At 10 a. m. patient voids completely. Save urine and label with time. Give 100 cc water. Take speci- men of blood for urea-nitrogen determination. At 11 a. m. patient voids com- pletely. Save urine and label with time. If urine specimens are not obtained exactly 1 hour apart, the number of minutes must be precisely known by the laboratory. Send all specimens to laboratory. By urea clearance is meant the volume of blood which is entirely cleared of urea by the kidneys in 1 minute. Sugar Tolerance.—This study of sugar tolerance has clinical value in a variety of conditions. The test is carried out as follows: After an overnight fast, ingest 100 Gm. dextrose dissolved in 300 cc black coffee. Collect blood samples just before feeding and at 45 and 120 minutes after same and determine the blood sugar in each sample. If the blood sugar has not by then returned to normal or about normal one may test further samples taken at hourly inter- vals. Venous blood, not finger blood which is practically arterial, should be used. The urine may also be collected and tested for sugar. A normal person should show no glycosuria (excretion of glucose in urine) and his blood sugar will be at its maximum (about 150) within 45 minutes and normal again after 120 minutes. The usual abnormal variation consists in increased height or, especially, prolonged duration of curve before reaching normal, as much as 6 hours being not unusual. The research work reported on the problem of sugar tolerance indicates that it is best to interpret an abnormal curve simply as indicating an impaired sugar tolerance and its degree. High blood sugar and alimentary glycosuria may readily be produced in cases of hyperthyroidism. Hyperglycsemia (excessive glucose in the blood) may occur in nephritis due apparently to raising of the threshold point of the kidney for glucose. Hyperglycsemia and flattened sugar tolerance curves are often found in hypoendocrine (low endocrine secretion) conditions. Low blood sugars (60-90 Mg. per 100 cc) are reported in myxoedema, cretinism, Addison’s disease, and pituitary disease. Gastric analysis. The stomach mucosa normally secretes 1,000 to 1,500 cc of liquid in each 24 hours. This is called the gastric juice. It mixes with the food so that even if no liquid is swallowed at meal time the stomach contents soon become liquid. The gastric juice contains hydrochloric acid in a concentration of 0.4 to 0.5 per cent, pepsin, rennin, and lipase. These aid in digesting the food. In certain diseases the hydrochloric acid may be increased in amount and in other dis- eases diminished or absent. Also when the stomach retains the liquid contents too long fermentation takes place and lactic acid develops. Therefore tests are made to determine the amount of liquid present 12 hours after eating, the 898 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY percentage of acid, both free and combined, with the food, and the presence of lactic acid. Sometimes easily recognized foods, as prunes, are given the night before and looked for in the residual stomach contents. This fluid is removed by a small rubber duodenal tube passed into the stomach. After the residual stomach contents are removed the tube is left in place while an Ewald test meal is eaten. This test meal consists of 2 pieces of toast (about 35 6m.) and 400 cc of water. After the test meal small quantities may be removed every 15 minutes until the stomach is empty or the entire stomach contents removed at the end of 1 hour, care being taken to have the patient lie successively on his back, abdomen, right and left sides to facilitate getting all the fluid. The stomach contents thus obtained are examined to determine the quantity of acid, both free and combined, with the food. Also tests are made for pepsin and occult (invisible) blood and a microscopic examination to discover any pus cells, blood cells, yeasts, cancer cells or large fermenting bacteria (Boas-Oppler bacilli). The acid content is expressed in degrees, indicated The number of degrees reported shows the number of cubic centimeters of N/10 alkali needed to neutralize 100 cc of gastric contents. Duodenal drainage. A tube is passed into the duodenum and specimens obtained before and after introduction of magnesium sulfate solution. Magnesium sulfate stimu- lates emptying of the gall bladder into the duodenum. Gall-bladder bile is concentrated and brown in color. The specimens are examined as to amount, color, turbidity, and presence in the sediment of crystals of cholesterin, calcium bilirubin, bile-stained epithelium or leucocytes, and flagellates (Giardia lamblia). If both cholesterin and bilirubin crystals are found in the gall-bladder bile specimen the presence of gall stones is strongly indicated. liver function tests. Icterus Index.—The color of the blood serum is matched against an arbitrary standard of 1-10,000 solution of potassium dichromate in a colorimeter. The normal index is 2-6, latent jaundice 7-15, and clinical jaundice from 16 up. A good test for the degree of jaundice. Harmless pigments such as carotin from foods may color the serum if a fasting blood specimen is not obtained. Beomsulfalein Dye Test.—The dye is injected intravenously in a dosage of 5 mg. per kilogram of body weight. Samples of blood are withdrawn 5 minutes and 30 minutes after the injection. The blood serum is matched against a standard. Any retention of dye above 50 per cent after 5 minutes, or the presence of any dye after 30 minutes, is indication of hepatic diseases. Galactose Liver Function Test.—Forty grams of galactose are given on a fasting stomach. The bladder is emptied. Five subsequent hourly specimens of urine are collected and Benedict’s quantitative test for sugar is performed on each. Excretion of over 3 grams of sugar is assumed to indicate hepatic functional impairment. Van Den Beegh Test.—Ehrlich’s diazo reagent is added to blood serum and the time of appearance of the maximum color is noted. If a reddish violet color appears within 30 seconds the reaction is immediate direct and indicates obstruc- tive jaundice. If the color appears after 30 seconds the reaction is delayed direct and indicates haemolytic jaundice. An indirect reaction is a quantitative test for bilirubin in the serum by adding diazo reagent followed by alcohol and ammonium sulfate. Normal serum contains from 1-3 mg. of bilirubin per liter. Any amount above this is abnormal. LABORATORY PROCEDURES AND TECHNIQUE 899 Urobilinogen Test.—Ehrlich’s reagent is added to urine. A pinkish color appears in the presence of urobilin. A positive test in a dilution up to 1-10 is normal. Diffuse liver damage is indicated by positive tests in higher dilutions of the urine. A negative test in undiluted urine is found in complete obstruction of the common bile duct. Urobilin is formed in the intestine by the action of bacteria on bilirubin. It is reabsorbed and reconverted into bilirubin by the liver and reexcreted in the bile, except for a small amount which is normally passed in the urine. If the liver is damaged it is unable to convert the urobilin to bilirubin and it passes out in the urine. If the common bile duct is completely obstructed no bile enters the intestine and no urobilin is formed. BACTERIOLOGY This discussion of bacteriology and haematology is not intended to serve as a working manual for laboratory use, but rather to outline the principles involved, the general methods, and something of the application of the more common procedures. Details of technique that are absolutely essential for the proper performance of any test are available in the manuals of laboratory work that are supplied to the medical department of all ships and stations. The microscope. The most important single piece of apparatus in a laboratory is the micro- scope, and it must be used and cared for accordingly. It is used to magnify and so make visible to the eye very small bodies, such, as bacteria, the eggs of intestinal parasites, and the material found in urine sediments. A simple microscope is nothing more than a single magnifying lens. A compound micro- scope, which is the type used in medical laboratories, consists of a number of such lenses arranged in line so as to give a very great magnification, even up to 1,000 times the actual size. Complete and detailed descriptions of micro- scopes are to be found in all books on laboratory work. Before attempting to use a microscope for the first time one should read over a description of its parts and their functions so that it will be possible to adjust the light and the lenses properly. There are a few important things to keep in mind regarding its use, and they are: Never leave the microscope exposed to direct sunlight, excessive heat, or splashing water; never use ether, alcohol, or xylol to clean it, as they all destroy the finish; never pick it up by any of the movable parts; never leave immersion oil on the lens or objective, as it is called, but wipe it off immediately after use with a fine, soft cloth or with special lens paper; when not in use see that it is well covered to protect it from dust. Mxcromettey is the measurement of microscopic bodies. The unit is called the micron and is one one-thousandth part of a millimeter, or one twenty-five thousandth of an inch. A glass disk, with a scale etched on it, is inserted in the eyepiece of the microscope and there it is at the level at which the image of the object on the stage is brought to a focus. The lines of the scale seem to cut the object and the number of divisions of the scale covered by the object is noted. The scale must be standardized for each objective of each micro- scope it is used with. Since the value in microns of one division is thus known and, knowing how many divisions are covered by the object, its size is determined by multiplying these values. Culture media are the materials used for the growth of bacteria in the labora- tory. Simple media are so made that they simulate to a greater or lesser degree the conditions present in the human body, where the bacteria have been grow- 900 HANDBOOK OF THE HOSPITAL CORPS, TJ. S. NAVY ing. The basis of most media is bouillon or broth which is a solution of meat juice, salt, and peptone in water and having a definite degree of acidity. The acidity may be determined by titration. The more modern and satisfac- tory method is to determine the hydrogen ion concentration or its pH value. The usual pH value is about 7.5, approximating that of blood. A few bacteria require media of other values for their cultivation. Simple nutrient broth may be modified by the addition of agar, making it solid, and is then known as nutrient agar. To the latter blood may be added, producing blood agar. In the same way other body fluids, such as hydrocele fluid, may be added, making the enriched media required by some of the more delicate organisms. Figure 167.—1, Filling tubes ; 2, plugging tubes; 3, inoculating tubes; 4, culture flask plate; 5, Durham fermentation tube ; 6, Smith fermentation tube; 7, pharyngeal loop for meningococcus pharynx cultures; 8, West tube for same. (Stitt.) Other substances are used as media, such as milk, broth with sugars added, coagulated blood serum (Ldfflers, particularly useful for Corynebacterium diphtherife), and many others used for special purposes. Milk is used to determine whether the organism produces acid by fermenting the lactose of the milk (shown by a change in the litmus indicator) and whether it produces enzymes that will coagulate the milk. Sugar broth is used In fermentation tubes and always contains an indicator such as litmus. If an organism produces acid, the indicator changes color. If it produces gas as well, some of the gas is collected in the closed branch of the tube. The various activities of organisms on culture media, such as the appearance of the colony, produc- tion of acid and gas in one sugar and not in another, have been classified and serve to identify the specific organism. Media, after preparation, are put up in tubes—fermentation tubes, flat glass dishes with covers known as Petri dishes, or in flasks, and are then sterilized. Sterilization of culture media is accomplished by means of heat, either from streaming steam in an Arnold sterilizer or by steam under pressure in LABORATORY PROCEDURES AND TECHNIQUE 901 an autoclave. Glassware often is sterilized by dry beat. Fractional steriliza- tion is repeated sterilization at 1 to 24 hour intervals and is employed to kill bacteria developing from spores. As the dust of the air is loaded with bacteria all media must be kept covered or, if in tubes, plugged with cotton from the time first made. Bacteria are very small single-celled bodies, visible only through a micro- scope. They are distributed almost universally in soil, air, water, and in the human body. The mouth and throat contain enormous numbers; milk and butter contain millions. The large intestine contains countless numbers, and a large part of the solid matter of the faeces is made up of bacteria. It is evident, therefore, that not all of these bacteria produce disease, and some of them are harmless or even distinctly beneficial to the body and are called nonpathogenic. Many bacteria are known to produce disease, and these are called pathogenic. In order to study bacteria they are grown on culture media, the different organisms separated out and then grown in pure culture for identification. As the majority of bacteria of medical interest grow in the human body the media employed for laboratory growth must be kept at body temperature; hence cultures are kept at a constant temperature of 37.5° O. This is known as incubation and usually is continued for 24-hour periods. Bacteria are classified according to the appearance of colonies, the shape and arrangement of the individual cells, their color when stained by appropriate methods, whether or not they are motile (have the ability to move from place to place in fluid), by their action on milk and sugar bouillon and by their action on experimental animals. The three usual types are the round organ- isms, or cocci, rod shaped, or bacilli, and spiral forms, or spirilla;. All of them are killed by boiling, many of them by a lower temperature if prolonged suf- ficiently. Some grow only in the presesnce of oxygen and are called aerobes, while others require an atmosphere free of oxygen and are called anaerobes. They reproduce by fission or simple splitting into parts. Some of them produce bodies called spores that are much more resistant to high temperatures, drying, and cold than the bacteria and serve to produce new organisms when material containing them again is placed in surroundings favorable to bacterial growths. Filtrable viruses are organisms so minute that they will pass through the pores of a porcelain filter. They cause the following diseases: Small pox, varicella, lymphogranuloma inguinale, foot and mouth disease, herpes febrilis, epidemic encephalitis, poliomyelitis, rabies, benign lymphocytic chorio-meningitis, influenza, common cold, measles, mumps, dengue, yellow fever, and sandfly fever. Smears are thin spreads of pus, blood, bacteria, or similar material on a glass slide. They may be made from material from the throat, from sputum, from an abscess, or of blood. The first essential for a proper bacteriological examination is a good smear, and the chief difficulty is to get it thin enough. If a culture is to be examined, place a loopful and a drop of distilled water on a perfectly clean glass slide and with a sterile platinum wire rub up some of the bacteria in the water, spreading it over as large an area as possible. If the bacteria are in fluid media, the water is not needed. For examination of piis use a cotton swab or a loop and spread out just enough of the material to make a visible film on the slide. Smears of sputum should be made from fresh material—that is, material recently coughed up from the lungs and as free of mouth secretions or saliva as possible and collected in a clean container. For the smear select a thick lump of mucus and avoid the frothy, watery saliva. Smears are allowed to dry in the air and then are fixed to the slide by passing through a flame two or three times. Blood smears should not be fixed by such 902 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY heating. The smear then is ready for staining with whatever dye is indicated, Gram’s method being the best routine process for most bacteria, except tbe tubercle bacillus which requires the acid fast staining method. Stains are substances used to color bacteria and tissue cells so that their morphology may be studied microscopically. They are usually solutions of anilin dyes in water or alcohol, but a few are derived from vegetable sub- stances. The more common stains are hsematoxylin and eosin, used for tissue staining, and methylene blue, carbol fuchsin, gentian violet, and safranin for bacteria. Each of these is made up for use in definite strength, alone or in combination with another dye. For some purposes several stains are applied successively, as part of the material will take up and retain one stain while other parts will react with another dye. This is the principle of Gram’s method and of acid-fast staining for tubercle bacilli. Gram’s stain.—1. Stirling’s gentian violet solution; Five grams of gentian violet are ground in a mortar with 10 cc of 95 per cent alcohol. After prac- tical solution, 2 cc of anilin oil are added and then 88 cc of distilled water. The grinding is continued a short time and then the mixture is let stand a day or two when it is filtered through paper. It has the merit of staining quickly and intensely and of keeping many months. 2. Gram’s iodine solution : The formula for this solution is: Iodine I 1 gram. Potassium iodide 2 grams. Distilled water 300 cc. 3. Decolorizing agents: Alcohol and acetone, equal parts; or alcohol, 95 per cent. 4. Counterstains: (a) Dilute carbol fuchsin: One part carbol fuchsin in .10 parts water; (&) Safranin: 10 cc of saturated alcoholic solution of water soluble safranin with 90 cc of distilled water. 5. Technique: The film should be thin, dried in tbe air, and fixed by passing through the flame or with methyl alcohol. The gentian violet is applied for one-half minute and washed off. The Gram’s iodine solution is applied for one minute or longer and washed off. Alcohol 95 per cent or alcohol and acetone equal parts are now dropped on the film until no more violet color streams out. Wash with water and apply one of the counter stains for 1 or 2 minutes. Gram-positive bacteria are stained a deep violet, whereas the Gram-negative organisms take the color of the counter stain. Method of staining acid-fast bacilli.—Carbol fuchsin (Ziehl-Neelsen), satu- rated alcoholic solution of basic fuchsin, 10 cc, and 5 per cent aqueous solution of phenol, 100 cc. (a) Dry smear in air and fix by passing through flame or with methyl alcohol. (&) Flood smear with stain and gently steam for 3 to 5 minutes. Wash in water. Decolorize with 95 per cent alcohol containing 3 per cent hydro- chloric acid, until only a suggestion of pink color remains. (c) Wash in water. (d) Counterstain with saturated aqueous solution of methylene blue. (e) Wash, dry, and mount. (f) Acid-fast organisms are stained red, other organisms and cells blue. Important acid-fast organisms are the tubercle and leprosy bacilli. Blood cultures are made to determine whether bacteria are present in the blood stream, thus serving as an index of the nature of the disease in some 903 LABORATORY PROCEDURES AND TECHNIQUE cases. Ordinarily about 10 to 20 cc of blood are required. It is taken from a vein by means of a needle and syringe or a needle connected by sterile tubing with a flask, observing strict asepsis throughout. The skin over the vein is sterilized with Tr. iodine and alcohol prior to the taking of the blood. The blood is received in sterile containers and transferred to appropriate media. Usually it is added to bouillon and in varying proportions to melted agar that has been cooled below 45° C. and then is poured into Petri dishes and incubated. Blood for the Wassermann reaction and Kahn test are taken in the same manner, preparing the patient’s arm, constricting above with a tourniquet, and puncturing a vein with a needle. Here, as absolute asepsis of the blood is not required, the blood may be permitted to run from the end of the needle into a tube, but it is better to collect it in a closed system of apparatus. Dark-field examinations usually are made on serum from sores on the geni- talia to detect the Treponema pallidum, the organism causing syphilis. For this purpose a special substage condenser replaces the ordinary Abbe con- denser of the microscope. It is so constructed that light rays are prevented from passing directly from the mirror to the objective by a light-proof black surface. Light is reflected by means of mirrors around the sides of this dark field and so illuminates the organisms or cells that may be present in the fluid on the slide. Ordinary daylight is not sufficient, and special lamps are required. To make the preparation the suspected sore is cleaned of all accumulated secretions with sterile gauze and physiological salt solution. Then it is rubbed sufficiently to promote a flow of serum but not to draw blood. A drop of this material is placed on a slide and immediately covered by a water glass and examined while still moist. The Treponema pallidum is examined in a dark-field preparation because it does not take the ordinary dyes, and when stained by one of the more complicated methods loses many of its characteristics. Other organ- isms may be seen in the dark-field preparation, but as they are stained easily, this method Is not employed. There are a number of spiral-shaped organisms that occur in ulcerative lesions, so great care must be exercised in making a positive report of Treponema pallidum. Bacteriophage is a filtrable, particulate substance which causes lysis or dissolution of susceptible bacteria. It can be obtained from faeces or sewage and can be transmitted indefinitely from one culture to another with increase in quantity. Agglutination tests.—If the serum of a typhoid fever patient is added to a culture of typhoid bacilli clumping or agglutination of the bacteria takes place. This is called the Widal reaction. Several other diseases can be diag- nosed by agglutination tests, among them meningitis, tularaemia, undulant fever, cholera, paratyphoid fever, using the patient’s serum and the causative organism. Pneumococcus typing.—Thirty-two strains of pneumococci have been identi- fied. If rabbits are injected with these strains 32 specific serums can be obtained which when added to pneumococci in pneumonia sputum cause swell- ing of the capsule of the organism enabling the specific strain to be identified. This is the Neufeld reaction. Sensitization tests.—Many people are hypersensitive (allergic) to certain proteins (foods, epidermals, pollens) and suffer from asthma, hay fever, urti- caria, etc. Extracts of the proteins when applied as a scratch test or intrader- mally produce a local urticarial wheal in a person sensitive to the particular substance. {See section on Allergy.) 904 HANDBOOK OF THE HOSPITAL COUPS, U. S. NAVY Friedman test for pregnancy.—If the urine of a pregnant woman is injected intravenously into a virgin female rabbit, hsemorrhagic follicles can be seen in the ovaries of the rabbit within 24 hours. This test is of great value in the early diagnosis of human pregnancy. Schick test.—Inject intradermally 0.1 cc of diphtheria toxin. If a reddened area appears within 24 hours and reaches a maximum after 2-3 days the test is positive and indicates that the individual is lacking in antitoxin and is sus- ceptible to diphtheria. Dick test.—Scarlet-fever toxin is injected intradermally. If the person is sus- ceptible to scarlet fever a red infiltrated area appears within 24 hours. Mantoux test.—Tuberculin is injected intradermally. A local reaction indi- cates past or present tuberculous infection. If a scratch test is used it is called a Yon Pibquet test. Frei test.—An antigen made from an emulsion of a mouse’s brain infected with the virus of lymphogranuloma inguinale is injected intracutaneously. A local reaction which persists for 3 days or longer is diagnostic of lymphogranu- loma inguinale. Paul, and Bunnel test.—When the human serum is added to sheep corpuscles agglutination occurs at dilutions of 1 to 8, or 1 to l(i. Serum from patients with infectious mononucleosis agglutinates sheep cells in high dilutions. Serum from leucsemic patients agglutinates in dilutions of 1 to 4 or less. Following is a list of important pathogenic bacteria and the diseases in which they are the primary causative agent: Organism Disease Gram Positive Bacillus anthracis_ Clostridium tetani {B. tetani) Corynebacterium diphtheria; (B. diphtherias) Diplococcus pneumoniae (Pneumonoccus) _ Mycobacterium leprae (B. leprae) Mycobacterium tuberculosis (hominis) (B. tuber- culosis) . Staphylococcus. Streptococcus. _ _ _. Anthrax. Tetanus (lockjaw). Diphtheria. Pneumonia. Leprosy. Tuberculosis. Boils, abscesses. Cellulitis, scarlet fever. Gram Negative Eberthella typhosa (B. typhosus) _ „ _ Haemophilus ducreyii {B. of chancroid) . Haemophilus influenzae (B. influenzae) Klebsiella pneumoniae {B. pneumoniae) (Fried- lander). Neisseria gonorrhoeae {Gonococcus) _ Neisseria intracellularis (Meningococcus)._ Pasteurella pestis (B. pestis) _ Pasteurella tularensis {Bacterium tularense) Salmonella enter!tidis {B. enteritidis) Salmonella paratyphi {B. paratyphosus (H)) Salmonella schotmiilleri {B. paratyphosus {B))__ Shigella dysenteriae {B. dysenteriae) Vibrio comma {Spirillum cholerx) _ Typhoid fever. Chancroid. Bronchopneumonia. Pneumonia. Gonorrhoea. Epidemic meningitis. Plague. Tularaemia. Food poisoning. Paratyphoid fever A. Paratyphoid fever B. Dysentery. Cholera. LABORATORY PROCEDURES AND TECHNIQUE 905 Counting blood cells. Complete blood count—This includes the determination of the number of red and white cells in 1 cubic millimeter of blood, the percentage of hfemo- globin, and a differential count which determines the percentage of each type of white cells present. Cells are so numerous in the blood that it must be diluted to separate them and permit the counting of individual cells. The dilution is accomplished in special pipettes (marked 101 for red count and 11 for white count), first taking up blood and then the proper diluting fluid. The pipettes are so graduated that known dilutions may be made. One part of blood to 200 parts of fluid gives a dilution of 1-200 for the red pipette and 1-20 for the white. The pipettes must be clean and dry before use, and this is accomplished by washing out with water, sucking alcohol through to wash out the water, then ether to take out alcohol, and then air to evaporate the ether. The bulb of the pipette or mixing chamber contains a glass bead to aid in thoroughly mixing the diluted blood; and if cleaned properly, the bead will not stick to the sides of the bulb. Red blood count.—Cleanse finger tip with alcohol, let dry. Puncture with sterile needle. Draw blood to exactly 0.5 mark, wipe off tip. See that the blood column reaches from the tip to mark. Draw up diluting fluid (Hayem’s) to 101 mark. Cover ends of pipette with thumb and finger and shake vigor- ously to thoroughly mix. Blow out 2 or 3 drops and discard, then apply a drop to the top of the ruled platform of the counting chamber of the hema- cytometer at the edge of the cover slip and allow enough of the diluted blood to run in by capillary attraction to fill the space beneath the cover. This space is 0.1 mm. deep. Allow erythrocytes to settle and using the high dry objective find the large center square which is divided into 400 small squares. Count the number of red cells in 80 of these squares and add four ciphers for the correct red blood count. A normal red blood count is 4.5 to 5 million per cubic millimeter. Hayem’s solution consists of bichloride of mercury 0.5, sodium sulfate 5, sodium chloride 1, distilled water 200. White blood count.—Draw blood to 0.5 mark and diluting fluid (3 per cent acetic acid, or tenth normal hydrochloric acid to the 11 mark. Mix and blow out two drops. Fill the counting chamber. Allow to settle and count the leucocytes under low power in those square millimeters at each of the 4 corners of the Neubauer ruled areas and multiply the total by 50. A normal white blood count is 5 to 10 thousand per c. mm. of blood. A count below 5,000 is called a leucopcenia and above 10,000 a leucocytosis. Differential count.—This is made on a stained smear of undiluted blood. Smears are made on slides or cover slips that are clean and free of all grease. Smears on slides are made by drawing out a drop of blood on one slide by means of the end of another slide. With cover slips, a drop of blood is taken up on the center of one and a second dropped on it. The blood spreads out rapidly in a thin film and then the slips are separated by a sliding motion. Both methods are illustrated. The smears are dried in the air and then stained with Wright’s stain. This stain is made by adding 0.3 Gm. of the dye to 100 cc of pure methyl alcohol and put aside for a few days to ripen. To stain cover blood smear with the stain for one minute then dilute with equal amount of freshly distilled water and allow to stain for 3 to 6 minutes. Wash off, let dry and examine with the oil immersion objective, counting 100 cells. The number of each type of white cells then gives the percentage of each. The identification of the various types of leucocytes is best learned by examining many slides with the aid of an experienced technician. HEMATOLOGY 906 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The Schilling classification of leucocytes for differential count and their normal percentage follows: Basophiles 0-1, eosinophiles 2-4, myelocytes 0, juveniles 0-1, band forms 3-5, segmented neutrophiles 51-67, lymphocytes 21- 35, monocytes 4-8. In severe infectious diseases the number of band and juvenile forms increases at the expense of the segmented neutrophiles and is known as the “shift to the left.” In certain diseases abnormal or patho- logical cells appear. Among the latter are the myeloblasts and myelocytes of myelogenous leucaemia and the lymphoblasts of lymphatic leucaemia. Figure 168.—1, 2, 3, 4, Making blood smears on slide; 5, smear ready for staining— grease marks prevent Wright’s stain from running over slide; 6, U-shaped glass tubing to hold title in staining; 7, right hand holding two cover glasses—one cover glass is being touched to drop of blood from ear; 8, cover glasses transferred to left hand in preparing to place one cover glass on another and spread film; 9, separating cover glasses by sliding one from the other. (Stitt.) The stained smear also is used to demonsti’ate the presence of malarial parasites, the staining qualities of the red cells, and their shape, size, and whether or not any of them show nuclei. Hemoglobin is the coloring matter of the erythrocytes and is estimated by adding tenth normal hydrochloric acid to blood (which converts haemoglobin to haematin) and comparing the color with the color scales of a Sahli or Haden- Hausser haemoglobinometer. It is reported either in per cent of normal or as grams per 100 cc of blood. Coagulation time of the blood is determined by filling a piece of capillary glass tubing with blood. At half minute intervals break off a portion. When coagulation has taken place a wormlike coagulum can be pulled out. Normal coagulation time is 3 to 6 minutes. A long coagulation time is seen in Inemophilia and some jaundiced patients. Sedimentation test.—Five cc of blood are placed in a Cutler graduated tube containing 0.5 cc of 3 per cent sodium citrate solution to prevent clotting. LABORATORY PROCEDURES AND TECHNIQUE 907 As the blood settles a reading is made every 5 minutes for 1 hour and recorded on a graph. The normal sedimentation index for men is 2-8 mm. It is slightly higher for women. Sedimentation increases with increasing destructive processes of disease, hence is a good prognostic indicator. ANIMAL PARASITOLOGY General considerations. While there are many lower forms of animal life that are parasitic for man, only the most common ones will be considered in this section. Before discuss- ing the systematic relationships, structure, and life history of these parasites, there are certain terms employed in animal parasitology which it is necessary to understand. Among these are: 1. Hosts.—The animal in which a parasite undergoes its sexual life is called the definitive or final host, that in which it passes its nonsexual or larval existence the intermediate host. For example: Man is the intermediate host of the malarial parasite, the mosquito the definitive host. 2. True parasitism.—By this is understood the condition where the parasite does harm to the host, deriving all the benefit of the association. A good example of this is the hookworm infecting man. 3. Mutualism.—In such an association there is mutual benefit to each party of the association. An instance of this would be the oyster crab found inside the oyster shell. 4. Commensalism.—Where there is benefit to the parasites but no injury to the host. An example of this would be the Endamceha coli in the intestine of man. 5. Ectoparasites.—Those living upon the body of the host. Example: In- festation with lice. 6. Endoparasites.—Those living within the body of the host. Example: Infection with hookworms, 7. Male parasites are designated by the sign of Mars ( $ ) ; the female by the sign of Venus ( ? ). 8. The name of a parasite consists of its generic and specific names. The first or the generic name always commences with a capital. Example: Cimex lectularius, the name of the bedbug. Classification. Practically all animal parasites of man belong to the following zoological phyla, or branches: 1. Protozoa (one-celled animals); 2. Vermes (low*er worms) ; and 3. Arthropoda (mites, ticks, and insects). Protozoa are one-celled animals and are made up of protoplasm, which is divided into cytoplasm and a nucleus. There are four groups of protozoa as follows: 1. Sarcodina ; 2. Flagellata ; 3. Infusoria ; and 4. Sporozoa. (Fig. 169.) saroodina.—This class of protozoa moves and secures food by throwing out protoplasmic projections called pseudopodia, or false feet. Evdamwha histolyt- ica, one of the parasitic intestinal amoeba of man, is the important member of this class. It exists in two stages, motile and encysted. Man acts as the definitive host. An intermediate host is not required. It is transmitted by cysts in food or water. Flies may act as carriers. It causes the disease known as amoebic dysentery. Diagnosis is made by finding the motile or encysted amoeba in the stools. flagellata.—This class sometimes is called the Mastigophora and includes those protozoa that move and obtain food by means of whiplike appendages, or flagella. Trypanosoma yamhiense is an important member of this group. This 154291°—39 58 908 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY parasite is fish-shaped, has two nuclei and a long flagellum. It lives in the blood and tissues of man. For its development two hosts are required: A fly (Olossina palpalis), the definitive host, and man, the intermediate host. It is transmitted by the fly biting man. It causes the disease known as trypano- somiasis, or sleeping sickness, a disease found chiefly in Africa. Diagnosis is made by finding the trypanosome in the blood or tissues of man. Intestinal flagellates such as Trichomonas, Chilomastix, and Giardia, are frequently found in an examination of the stools. Trichomonas vaginalis is an important flagellate often found in vaginal discharges. Figure 169.—Parasitic protozoa of man : 1, adult Endarnoeha histolytica; la, encylsted /<;. histolytica; 2, Plasmodium malariae, A, B, C, D, various stages ; Trypanosoma yambiense; 4, a, Treponema pallidum; b, Borrelia refringens; 5, Ballantidiurn coli; 6, Trichomonas hominis; 7, a, adult Oiardia lambliaj b, encysted O. lamblia. (Stitt.) infusoria.—This group frequently is called the Ciliata on account of the fine, hairlike fringe or cilia that surrounds them. These cilia aid in movement and securing food. Balantidium coli, a rather large intestinal protozoan, is the only member of this group of importance to man. It is transmitted similarly to Endamocba, and causes dysentery. Diagnosis is made by finding the parasite in the stool. sporozoa.—The protozoa have neither cilia, flagella, nor other organs for movement. They live parasitically in the tissue cells of the host, and repro- duce by forming spores. The ones that live in the red blood cells, Hoemosporidia, are of the most interest medically because they include the parasites that cause malaria. There are three types of malarial parasites of man: 1. Plasmodium malaria;, the cause of quartan malaria; 2. Plasmodium vivax, the cause of benign tertian malaria; and 3. Plasmodium falciparum, the cause of malig- nant tertian (aestivo-autumnal) malaria. These parasites require two hosts for their development, the definitive host, a mosquito (Anopheles), and man, the intermediate host. The development in the mosquito requires 10 to 21 days; LABORATORY PROCEDURES AND TECHNIQUE 909 thus, an anopheles mosquito biting a man suffering from malaria cannot infect another man until after this time has elapsed. In the body of a mosquito which has been infected by biting a person having some form of malaria the malarial parasite develops for from 10 to 21 days and then appears in the salivary glands of the mosquito in the form known as sporozoites and is ready for transmission to another host. By the bite of the infected mosquito the sporozoites are introduced into the blood stream of the new host where they enter the red-blood cells and are known as trophozoites. In the red cells the trophozoites rapidly mature, the benign tertian type in 48 hours, the quartan in 72 hours, and the malignant tertian in about 48 hours, and when full-grown they are termed schizonts. The nucleus of a schizont divides into minute particles which scatter through the cytoplasm of the parasite, later to become the nuclei of new parasites, and the cytoplasm splits into segments which each contain a nuclear particle and are called merozoites. The red cell then ruptures and the merozoites are released into the plasma whence they seek and enter fresh red cells where the cycle is repeated. Repro duction of the parasites continues for about 2 weeks (the incubation period) at the end of which time a sufficient number have been produced to cause the symptoms characteristic of malaria, the chill followed by fever. The chill in malaria is coincident with the rupturing of the red cells and is attributed to the sudden liberation into the blood of toxic substances, possibly excretory material of the parasites, from the disintegrated red cells. Diagnosis is made by examining a blood smear for the presence of these parasites. Vebmes are divided into two classes, the platyhelminthes, or flat worms, and the nemathelminthes, or round worms. platyhelminthes.—Of these parasites, known only as the flat worms, there are two classes: 1. The trematodes or flukes; and 2. The cestodes or tapeworms. Trematodes or flukes are generally leaflike in shape and vary considerably in size. Characteristic of them is the possession of suckers, by which they hold on to the skin or alimentary tract of their host. They develop from eggs, and the larval stage usually is passed in a snail. Some flukes require, in addi- tion to the snail, a second intermediate host, usually a fish. Man, the definitive host, contracts the parasites by eating insufficiently cooked fish or by bathing in or drinking infected water. The flukes of importance to man are: 1. Fasciolopsis buski, which parasite lives in the intentine, the diagnosis being- made by finding the fluke or its eggs in the stools; 2. Clonorchis sinensis, an important liver fluke, the eggs of which likewise are found in the stools; 3. Paragonimus ringeri, the fluke that lives in the lungs, the diagnosis being made by finding eggs in the fresh sputum; and 4. Schistosomes, which are the blood flukes, of which there are three kinds, Schistosoma hwmatobium, S. japonicum, and S. mansoni. Unlike the other flukes, the blood flukes are, not hermaphroditic, but have separate sex. Diagnosis is made by finding the eggs in the faeces or, in the case of S. haematobium, in both urine and faeces. Cestodes or tapeworms.—These consist of a head and a series of segments. The head, which is a little larger than a pinhead, is provided with suckers, or hooks, or sometimes both, to enable them to hold on to the intestine. The segments may number several hundred or more. Some tapeworms attain the length of 25 or 30 feet. In treating cases of tapeworm infection, it is imt- portant that the head be expelled, otherwise, in about two months, a full- grown worm again will develop. Among the important tapeworms of man are: Taenia saginata, Taenia solium, Hymenolepis nana, and Diphyllobothrium latum. 1. Twnia saginata is the common and widely distributed beef tape- 910 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY worm. Its head has four large suckers but no booklets and it often is called the unarmed tapeworm. The segments have a uterus showing 15 to 30 branches. The genital pores are lateral and alternate. Several hundred seg- ments may be present, and the worm varies from 10 to 25 feet in length. Man is the definitive host and cattle the intermediate host, infection being brought about by eating insufficiently cooked beef. 2. Taenia solium is the so- called pork tapeworm and is not as common as the beef tapeworm. Its head shows, in addition to suckers, a rostellum crowned by booklets, for this reason often being called the armed tapeworm. The segments have a uterus showing only 5 to 10 branches. Man is the definitive host and the hog the intermediate Figure 170.—Adult and larval stages of cestoda of man. (Stitt.) host. Infection is contracted by eating insufficiently cooked pork. 3. Hyme- nolepis nano, is one of the most common tapeworms and is called the dwarf tapeworm on account of its small size, it being only a quarter to a half inch in length. Its head has four suckers and a rostellum with a single row of booklets encircling it. There are about 150 to 200 segments. The gen- ital pores are lateral and all are on the same side. Man acts as both the definitive and intermediate host. As many as 1,000 worms may be present at one time. Infection is caused by swallowing the eggs. 4. Diphyllobothrium latum, the broad Russian tapeworm, has an olive-shaped head, with two slitlike suckers, broad segments with a rosette-shaped uterus, and may reach more than 30 feet in length. Segments sometimes number 3,000 or more. Man, the definitive host, contracts the infection by eating insufficiently cooked fish. Two intermediate hosts are recognized—first a cyclops (a minute, one-eyed shellfish) and second a fish. The eggs are operculated (have a lid) and the worms do not have the booklets characteristic of the other tapeworms previously discussed. The diagnosis of these worms is made by finding their segments or their eggs in the stools. (Fig. 170). LABORATORY PROCEDURES AND TECHNIQUE 911 nemathelminthes.—These woriiKS are known as roundworms on account of being tubular or filiform in shape. They are not segmented and are covered by a cuticle or skin, which is frequently ringed. An alimentary canal is usually present and complete. The sexes as a rule are separate. The male usually can be recognized by its smaller size, its curved posterior end, and at times exhibiting an umbrellalike expansion called the copulatory bursa. The most common roundworms are: Ascaris lumbricoides, hookworms, Trichuris tri- chiura, Enterobius vermicularis, Trichinella spiralis, and Wuchereria bancrofti. 1. Ascaris lumbricoides, the round or eel worm, probably is the most common parasite of man, especially children. They average about fi inches in length Figure 171.—la, copulatory bursa of Necator americanus, showing the deep cleft dividing the branches of the dorsal ray and the bipartite tips of the branches; also showing the fusion of the spicules to terminate in a single barb. Scale 1/10 mm. lb, Branches of dorsal ray magnified. 2a, the Buccal capsule of N. americanus. 2b, The same magnified 3a, Cop. bursa of Ancylostoma duodenale, showing shallow clefts between branches of the dorsal ray and the tridigitate terminations. Spicules hairlike. 3b, The dorsal ray magnified. 4a, The buccal capsule of A. duodenale, showing the much larger mouth opening and the prominent hooklike ventral teeth. 4b, The same magnified. 5a, Egg of N. americanus. 5b, Egg of A. duodenale. 6a, Rhabditiform larva of Strongyloides as seen in fresh faeces. 6b, Rhabditiform larva of hookworm in fasces 8 to 12 hours after passage of stool. (Stitt.) and are grayish to reddish in color. An intermediate host is not required. Infection takes place through food or drink or by fingers of children who have been playing where soil pollution exists. The adults live in the intestine. 2. Hookworms (fig. 171). These roundworms are of considerable importance from a medical standpoint. Human infection comes almost entirely from two types of hookworms, Ancylostoma duodenale, the Old World species, and Neca- tor americanus, which generally is called the New World species. They average about one-half inch in length. The males are distinguished from the females by their expanded posterior end. The large open mouth of the Old World hookworm has four claw-like teeth on the ventral side and two knob-like teeth 912 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY on the dorsal aspect; the New World hookworm has a smaller round mouth and the ventral teeth are replaced by plates, and it also has a prominent dorsal tooth projecting into the mouth cavity. Man is the definitive host and an inter- mediate host is not required. Infection takes place by larva in polluted soil penetrating the skin from where the larvae make their way to the intestine, and there develop into adults. 3. Trichuris trichiura, usually called the whip- worm on account of the thickened body resembling the handle and the narrow neck the lash, is one of the most common parasites in both temperate and tropical climates, and averages about 2 inches in length. It does not require an intermediate host. The diagnosis of the three roundworms described is Figure 172.—Nematode ova. (Stitt.) made by finding the adults or their ova (fig. 172) in the stools. 4. Enterobius vermicularis, a parasite commonly known as the pin or seat worm and found more frequently in children than in adults. The male is about one-sixteenth of an inch and the female about one-half inch in length. The male has an in- curved tail with a single spicule and the female a long tapering tail. The female, loaded with eggs, wanders out of the rectum, and, as the result of scratching, the fingers become contaminated with the eggs, which may be carried to the mouth and cause a fresh infection, an intermediate host thus not being required. Diagnosis usually is made by examining the stools for the white, threadlike females, which usually are expelled after a purgative. 5. Trichinella spiralis is the cause of trichinosis. The adults live in the in- testine and are about one-sixteenth of an inch in length. The female does not lay eggs, but gives off larvae directly which wander to the muscles of the body. Man acts as the definitive host and hogs as the intermediate host, infection being contracted by eating insufficiently cooked pork. Diagnosis is made in the first 5 days of the disease by finding the adults in the stools, after that time by finding the larvae in the blood or muscles. 6. Wuchereria hancrofti is the most important of filarial worms and causes an infection common in tropical LABORATORY PROCEDURES AND TECHNIQUE 913 countries. The adult worms live in the lymphatics and are about 2 inches in length. The female normally does not lay eggs but gives off larvae, which enter the blood stream. Characteristic of this parasite is the appearance of the larvae in the blood stream only when the patient sleeps. Man is the definitive host, and the mosquito, especially the Culex quinquefaciatus, the intermediate host. It takes about 3 weeks for the larvae to develop properly in the mosquito before they can infect another man. Diagnosis is made by the presence of the larvae in the blood stream. The Arthropoda is the other branch of animals which will be particularly discussed in this section. Of these, from a medical standpoint, interest cen- ters in two classes only, the arachnids and the insects. arachnida.—This class includes the mites and ticks, which differ from the insects in having a head and thorax fused together and possessing four pairs of legs instead of three, and the spiders. A common parasite belonging to this class is the Sarcoptes scahei, the human itch mite. This minute, whitish mite causes a skin disease known as scabies. The disease is brought about by the female mite burrowing into the skin, where eggs are laid, from which come young mites that are to spread the infection. Diagnosis is made by examining the skin scrapings under the microscope for the presence of the mites or their eggs. The tick family of arachnids is of great and increasing importance medi- cally. It was through proving the tick transmitted a disease of cattle in Texas that the zoological principle of transmission of diseases by means of arthropod hosts was estab- lished. Ticks are much larger than mites, readily being seen by the unaided eye. They are wholly parasitic in their habits. Some of them live on their host practically all their lives, dropping to the ground to deposit their eggs. Among the ticks of importance are: Ornithodoros mouhata and Dermaccntor andersoni (fig. 173). 1. Ornithodoros mouhata has a hard, rough skin, and on looking down on its back the head cannot be seen. It lives in the huts of the natives of Africa and has habits very similar to the bedbug, feeding at night and hiding during the day. It transmits a protozoan, Borrelia duttoni, which causes South African tick fever. 2. Dermaccntor andersoni. A tick found in the western part of the United States which can be roughly distinguished from the O. mouhata on account of its smooth skin and the head parts projecting beyond its body outline. It transmits the spotted fever of the Rocky Mountains. The dog tick, D. vari- ahilis, also transmits Rocky Mountain spotted fever which is due to the virus often called Dermacentroxenus rickettsi. Of the spiders, Lactrodectus mactans, the “black widow” or hour glass spider, is important because of her dangerous bite. She lives in outbuildings and is recognized by the black color and deep orange hour-glass shaped spot on the ventral abdomen. About 30 minutes after the bite excruciating pains are felt in various parts of the body particularly of the abdomen with marked rigidity of the muscles. insecta.—In this class are the mosquitoes, the fleas, flies, lice, and bedbugs. These parasites have three well-marked divisions of body: Head, thorax, and, abdomen; three pairs of legs and one pair of antenna;. Figure 173.—Ticks : 1, Ornithodoro* moubata; 2, Dermacentor andersoni. (Stitt.) 914 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The Culicidw or mosquitoes are of the greatest importance medically, not only from their influence upon health in general by reason of interference with sleep and possibly from direct transmission of disease but, more specifi- cally, because they are the only means by which it at present appears possible to bring about infection with such diseases as malaria, yellow fever, filariasis, and dengue. In the life history of mosquitoes (fig. 174) the female lays eggs in water or in places where water is apt to collect; otherwise they will not hatch. In from 1 to 4 days a larva or wriggler emerges and comes to the surface to breathe. These larvae are of two types—the siphonate and the asiphonate. The siphonate are so called on account of having a breathing Figure 174.—Life cycle of the Anopheles, Culex, and Aedes mosquitoes. (Stitt.) tube projecting from the tail end of the abdomen. When seen at rest this tube projects above the surface of the water and the head end of the larva hangs down at an angle. The larva of the mosquito (Culex) that transmits filariasis has a long, narrow siphon, and the larva of the yellow-fever mosquito {Aedes) has a short, barrel-shaped siphon. The asiphonate do not have this tube, but possess breathing slits and at rest float parallel to the surface of the water. This is the larva of the mosquito (Anopheles) that transmits malaria. This larva has another characteristic feature, namely, fan-shaped hairs on each side of its abdominal segments, called palmate hairs. After a period of about a week the larva enters a nongrowing, nonfeeding stage, called the pupa or nymph, from which in about 3 days the adult mosquito releases itself and flies away. It is desirable that the anatomical characteristics of mosquitoes be known to those who may have to examine them (Fig. 175). In examining an adult mosquito it will be noted that there are three divisions of the body: Head, thorax, and abdomen. The head shows a stout projection, called the pro- boscis, which contains the biting parts. In mosquitoes of medical interest 915 LABORATORY PROCEDURES AND TECHNIQUE this proboscis is long and straight. In males the biting parts are not strong enough to pierce the human skin; thus it is known that only the female bites. On each side of the proboscis are the palps, or sensory organs, and to the Figure 175.—Anatomy of mosquito: 1, Cross section of proboscis; 2, anatomy of mosquito, longitudinal section ; 3, tip of proboscis ; a, labium epipharynx; b, hypopbarynx; o, mandible; d, maxilla. (Stitt.) outer side of these are the antennae, or feelers. The male mosquitoes can be distinguished hy the heavily feathered antennae. The thorax supports the three pairs of legs and one pair of wings. The wings have a characteristic arrange- ment of the veins and show scales. Mosquito-like insects do not have scales on their wings. The abdomen has nine segments, and on the last seg- ment of the male are claspers. While there are about a dozen varieties or genera of mosquitoes, from a medical standpoint interest centers in but three of these genera, the Anopheles, the malaria mosquito; the Aedes, the yellow-fever mosquito; and the Culex, the filaria mosquito. To definitely differentiate these mosquitoes it is neces- sary to use elaborate keys and tables. But to tell whether a mosquito is a probable malaria or yellow- fever transmitter is a comparatively easy matter. The first step is to obtain a female, remembering that the antennae of the female are sparsely and not heavily feathered, as in the case of the male. The males also show claspers on tail end of ab- domen. Having secured a female, note the length of the palps (Fig. 176). If they are as long as the proboscis and clubbed and the wings of the mosquito are spotted, it is an Anopheles. If the palps are not as long as the proboscis and it is a small, black mosquito with silver or white markings on the back of its thorax it is an Aedes. A mosquito with short palps, without these markings, is probably a Culex. Pigdke 176.—M osquito heads showing heavily feathered male antenna and the long palps of the Anopheles female and the short palps of the Culex female. (Stitt.) 916 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The Siphonaptera or fleas (tig. 177) have come into prominence on account of their importance in connection with the spread of plagaie. In this case the transmission of the disease is mechanical; that is, by biting and depositing faecal matter containing the bacillus in the wound. The bacillus causing the disease is merely carried without change in the flea host. This is in contrast to what is known as a biological transmission, such as in the case of malaria and yellow fever, where the protozoan that causes these diseases undergoes a change in the mosquito host. Figdre 177.—Types of fleas and jigger : 1 and 2, male and female Xenopsylla chcopsis ; 3, head of Geratophyllus; 4 and 5, male and egg-distended female of Tunga penetrans. (Stitt.) Figure 178.—1. Pediculus humanus var. humanus. 2. Pediculus humanus var. corporis. 2a. Protruded rostrum of Pediculus. 3. Phthirius pubis. 4. Ci- mex lectularius. 5. Cimex rotundatus. 6. Triatoma megista. (Stitt.) The Pediculidce or lice (fig. 178) are of three varieties. The one living on the head is called the Pediculus humanus var. humanus, the one on the body the Pediculus humanus var. corporis, and the one living in the hairy region about the pubis, popularly known as crab louse, the Phthirius pubis. The body louse lays its eggs in the seams of the under-clothing and is important on account of transmitting European relapsing fever, trench fever, and typhus. The relapsing fever is due to a spiral shaped organism called Borrelia recurrentis. Trench fever and typhus are caused by miniate, chromatin staining, lanceolate organisms called Rickettsia. Flies.—The fly best known is the ordinary house fly Musca domestica. Its mouth parts are fitted for sucking and not biting. Its food must be in a liquid or semisolid state before it can be sucked up into its stomach. If it wishes to feed on any solid substance, such as sugar, it first pours out saliva to liquefy it. Many people think that the house fly can bite, but careful examination of such a biting fly will usually show it to be the stable fly, Stomoxys calcitrans. Perhaps the most dangerous parts of a fly are the pads or pulvillse on its feet. By means of these it can carry much filth frequently containing bacteria which cause typhoid fever and other diseases. Another important fly belonging to the same family as the house fly is the tsetse fly (Glossina palpalis), which transmits the Trypanosoma gamhiense, the cause of African sleeping sickness. Some flies, like the flesh fly (Sarcophaga carnaria), can cause considerable discomfort by laying their eggs in wounds or cavities like the nose, ear, etc., their eggs developing into larvae or maggots. Following is a list of important diseases due to animal parasites: PHYSICAL THERAPY 917 Parasite Disease Entamoeba histolytica _ Amoebic dysentery. Trypanosoma gambiense _ African sleeping sickness. Plasmodia malariae Malaria. Schistosoma japonicum. _ Japanese schistosomiasis. Tsenia saginata._ .. .. Beef tapeworm. Taenia solium. _ _ Pork tapeworm. Wuchereria bancrofti Filariasis. Diphyllobothrium latum Fish tapeworm. Hymenolepis nana. _ Dwarf tapeworm. Necator americanus. _ Hookworm. Sarcoptes scabiei Itch or scabies. Tunga penetrans Sand flea or chigger itch. Ascaris lumbricoides Ascariasis. Trichinella spiralis _ _ Trichinosis. References Practical Bacteriology, Haematology, and Animal Parasitology.—Stitt, Clough, and Clough. Clinical Diagnosis by Laboratory Methods.—Todd and Sanford. Laboratory Manual of Biological Chemistry.—Poiin. Clinical Laboratory Methods and Diagnosis.—Gradwohl. Textbook of Laboratory Diagnosis.—Osgood. Section 10.—PHYSICAL THERAPY Physical therapy is the application of physical energy in the treatment of diseases, injuries, and new growths. Physical therapy has become such an important part of many medical and surgical treatments that it should always be under the direction of a medical officer who has the training necessary for diagnosis, proper selection of modalities, and correlation of treatment with the other forms of medical and surgical prescriptions that may be necessary. For convenience physical methods may be classified as mechanotherapy, hydro- therapy, light therapy, and electrotherapy. MECHANOTHERAPY This method of applying physical energy in the treatment of disease Involves especially the use of movement and is sometimes called the therapy of move- ment. Massage and exercise are two ways of obtaining movement in treating disease. Massage. This is one of the oldest and most useful methods of physical treatment. It is a therapeutic manipulation of the soft tissues and is best mastered by manual demonstration and long practice. In massage there are three main varieties of movement which are used singly or in combination. To prevent causing unnecessary discomfort or pain to the patient the use of a lubricant such as cocoa butter, a bland oil, or an appropriate liniment is advisable. Stroking, or eflleurage, is fundamental and consists of even and uniform pressure exerted along a certain * path. The palm of the radial side of the hand is used on large surfaces, the thumbs in areas close to bone, and the 918 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY finger tips around small joints. The hands must be relaxed to follow the body contours, and should be warm, dry and clean, always kept in contact with the parts and always returned lightly to the starting point before changing direction. Stroking is always in direction of the venous flow and should be slow and rhythmic, about 15 strokes per minute. The patient’s muscles must be relaxed. In deep stroking, the pressure is deep but not heavy, and 4 or 5 strokes a minute are used to promote fluid flow. Fifteen to thirty light strokes per minute are used for sedative effect. Compression may be effected by kneading or friction. In kneading, the skin and subcutaneous tissue is picked up between the thumb and fingers, with pressure short of causing pain. It is best accomplished by the two hands opposed, as picking up small muscles between the finger tips, or with the finger tips against the palm rolling the muscles under them against the bone, as in the large muscle masses of the thigh and leg. The movement is always gradual, from the periphery inward. While pressure is being given, the skin is moved with the hand, and the part squeezed in the direction of the venous flow. The hand is never entirely removed from the part. Treatment is from the proximal end, distally in a muscle group but each individual motion is in the direction of venous flow. Kneading stretches retracted muscles and tendons, adhesions, and removes waste products from the muscle, friction is a circular form of kneading with pressure against underlying tissues that cannot be grasped. The tips of the thumbs, working in opposite directions, are used in small areas; the tips of the fingers around joints and the entire hand over large areas, as the back and thigh. It should always be preceded or followed by stroking, and carried out in the same general direction. Friction is used to free adherent skin, and to loosen scars and adhesions of deeper parts. (Mechanical vibration is also used.) Percussion, or tapotement, is the most stimulating form of massage and (he most apt to be overzealously employed, slapping is accomplished with the palmar surfaces of the fingers as quick alternating strokes, with the wrist relaxed and the fingers immediately rebounding. It is a powerful stimulation to the skin capillaries and nerve endings as well as to the entire nervous system. For hacking, the ulnar side of the hand and little finger is used to make rapid chopping motions, from the wrist, either light or heavy. Hacking is used for its effect on the deep structures, relaxing muscle spasm, breaking up organized exudates, and stimulating deep muscles. In tapping the tips of the fingers are used. In general, massage is used to aid lymphatic and venous flow, to loosen adherent scar tissue and stretch contractures, for its sedative effect, and to increase metabolism generally, to Improve muscle tone, strength, and relieve' spasm, and to improve skin function and tone. Massage should be given in a warm (70° F. to 75° F.) light room, with the patient comfortable, preferably reclining. In addition to those previously mentioned, talc is also a satisfactory lubricant, and oil should always be used over scar tissue. Warm the area by radiant heat or hot baths before massage. When used alone 10 to 15 minutes is the usual time, but 5 to 10' minutes is enough when other treatment is used in connection. Use massage daily in acute or painful conditions. Clinical uses of massage.—Recent injuries, fractures, Sprains, dislocations, stiff (not ankylosed) joints, arthritis, rheumatic conditions, gastro-intestinal atony, chronic constipation, flaccid and spastic paralysis are conditions which may be benefltted by massage. In central nervous conditions massage is used for its soothing effect. In chronic cardiac decompensation oedema may be decreased and the heart load lessened by cautious general stroking and gentle 919 PHYSICAL THERAPY kneading. Massage may be used in convalescence for its general stimulative effect. The type of massage and the time the procedures are to be used is deter- mined by the medical officer. Contraindications to massage.—Massage is not to be used in the following conditions: Acute skin diseases, skin and subcutaneous infections, over pig- mented moles, wounds, tumorous swellings, acute phlebitis and thrombosis, in- fectious arthritis, undrained osteomyelitis, inflammatory processes in the ab- domen, gastric or duodenal ulcers, acute neuritis, heart diseases, unless ordered by the medical officer, or varicose veins. Massage may be used around varicose veins. Exercise. In general the value of exercise in maintaining health is well recognized. Schools make provision for systematized exercise under the direction of teachers specially trained in physical education. A large part of the adult population has become acquainted with various “setting up exercises.” The Navy and military organizations employ calisthenics in their drill schedule. They also use competitive games and sports for their physical training as well as for the beneficial effect on morale. It is obviously better to force deep inspiration by activity, than by artifieal deep breathing. There are four general types of exercises used in therapeutics. Passive exercises are those done wholly by the operator, the weight of the patient’s body, or by utilizing some other external force. Assistive exercises are performed as far as possible by the patient, assisted by the operator. Active exercises are movements executed exclusively by the patient. Resistive exercises are done by the patient, opposed by friction, gravity, weights, the operator’s or the patient’s own physiologically opposing set of muscles. In nearly all faulty postures, not due to defects in the skeleton, the following factors are present: 1. Lack of balance in power of opposing sets of muscles; 2. Gradual shortening of the stronger set of muscles, and lengthening of the weaker set; 3. Gradual lessening in the flexibility and range of motion in the joints moved by affected muscles; and 4. A dulling of “muscle and joint sense” which causes the awareness of malposition. Every exercise regime must be aimed at correction of each of these factors, by strengthening weak sets of muscles, stretching those contracted, maintaining and increasing full flexibility, and developing the muscle sense. And lastly, development of the general physique is essential. Before starting treatment, all causes that can should be corrected or removed, as defective hearing and eyesight, improper sitting posture, pain, habitual uni- lateral carrying methods, improperly applied clothing and supports, nutritional defects, and deficient exercise. Therapeutic exercise is often preceded by the use of radiant light, short wave diathermy, mild sinusoidal current, and massage to warm and prepare the part for exercise. Clinical uses of exercise.—Many morbid conditions are benefitted by ex- ercise, a few of such conditions being: Hsemiplegia, cerebral degeneration, encephalitis lethargica (sleeping sickness), lesions of the spinal cord, injuries of the peripheral nerves, fractures, sprains, valvular heart disease, functional cardiac disturbrances. falling of abdominal organs (visceroptosis), constipation, tuberculosis, emphysema, and curvatures of the spine. The use of exercise 920 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY in any of these or in other conditions must always be as ordered by a medical officer. For information as to the programs of exercises to be used in the treatment of various disease conditions reference may be bad to any standard text on Physical Therapy. HYDROTHERAPY Hydrotherapy is a term used to designate the therapeutic procedures related to the external application of water to the body. Many of these measures are very simple and in common practice, and can be applied without special ap- paratus. with positive benefits to the patient. The outer layer of the human skin is essentially a waterproof covering under which is the true skin containing blood vessels and nerve endings, and still deeper the sebaceous and sweat glands. The effect of hydriatric measures consists of the reaction in the skin, and in the organs reflexly connected with it. Mechanical force adds to the effect of any hydriatric application. Water is applied in the treatment of disease at different temperatures with different reactions for each. The application of tepid water, 85° F. to 95° F., causes relaxation. The short application of cold water, 40° F. to 65° F., causes the skin to pale, the small blood vessels to constrict, and the muscular tissues to contract. This is followed immediately by relaxation and increased blood flow. There is deep inhalation at the time of application. With reaction the pulse rate slows and the heart is more efficient. A sense of well-being follows. This must not be used in persons of low vitality. The long applica- tion of cold water causes continued contraction of blood vessels, followed by total or partial relaxation and paralysis (a severe example is frostbite). A short, intense application of hot water, 100° F. to 110° F., causes the same immediate reaction as cold, but the primary effect subsides quicker. The result- ing hyperaemia is more widespread and is atonic in character. The local and general effect of continued local application of hot water corresponds to radiant heat. Fompresses are folded linen cloths placed over the part to be treated. They are slightly wrung out of water at the temperature desired, and held in posi- tion by dry flannel bandages. The size depends on the area to be treated and the temperature on the effect desired. gold compresses cause contraction of the peripheral vessels and are used for immediate relief of recent injuries, in the early stages of inflammation, and for combating swelling, redness, and pain. They may be renewed every half hour. In cerebral congestion (headache) apjily cold compresses to the forehead; in heart disorders they may be applied prsecordially. A stimulating compress is a cold compress under several layers of flannel. It causes first a vasoconstriction, then, with reaction, vasodilatation; the bandage dries in 1 to 4 hours. It is used over the throat in sore throat, laryngitis, and tonsillitis, over the chest in all pulmonary conditions, and over the abdomen in gall-bladder disease. hot compresses are applied in the same manner as cold ones but. at 105° F. to 115° F. In 1 to 2 hours they will produce intense hyperaemia, soften inflam- matory congestion, and relieve pain and spasm. Fule Coed Wet Packs are used for their sedative effect and as antipyretics. The temperature of the water should be between 60° F. and 70° F. Fuel Hot Wet Packs are used to increase elimination, The temperature of the water should be between 110° F. and 115° F, PHYSICAL THERAPY 921 Technique for applying either pack.—Spread rubber sheet over the bed and a blanket over the rubber sheet. Immerse a cotton sheet in the water at the temperature that has been ordered and wring out. Open sheet and spread over the blanket. Patient now lies fiat on his back on this sheet. Have the patient raise his arms above his head. Fold one-half of the sheet closely over patient’s body and high under his arms. Work fast. Have patient lower his arms to his sides. Wrap the remaining half of the wet sheet around the patient with the upper edge surrounding the neck. Press a fold down between the legs and feet and fold the lower end under the heels. Be sure the sheet clings snugly to the body everywhere. Fold the blanket smoothly around the patient and cover with an extra blanket on top. If feet will not warm up apply a hot water bottle to them. Patient may stay in the pack 45 minutes to 1 hour. Ablutions, full.—Pouring water over the entire body or part of it is a mild procedure to apply thermal stimuli. The patient sits in a tub and water at 60° F. to 70° F. is poured over the back and chest. The procedure should be short and not used in patients with high blood pressure. Partial or Towel Bath.—The patient is in bed, covered with sheet and blan- ket. Towels at 65° F. are applied in succession over arms and legs, chest and back. Each towel is rubbed until It feels warm. Each area is dried, covered, and the next area then treated. Do not use over 5 minutes. This bath is used on febrile and elderly patients and gives a mild stimulating effect. Sheet Bath.—The patient, on a rubber sheet, is wrapped in a sheet wrung out of 50° F. to 80° F. water. He is then rubbed until the sheet feels warm (2-3 minutes), quickly dried and put to bed, well covered. This bath stimu- lates vasomotor and nervous tone. Drip Sheet.—The patient stands with a wet towel on his head, and a sheet wrapped around him. As the sheet becomes warm attendants pour water over it at a temperature of 5° F. lower than the first used. It is a vigorous gen- eral nervous stimulant and antipyretic after 15 minutes. It may overtax a patient’s reactive powers, so caution must be used. Baths.—A short cold bath is given a few seconds to 2 minutes in a tub of water at 60° F. to 65° F. The skin is rubbed and as soon as dried the patient exercises or is given a massage. Cold baths must not be used in hypertension, weak heart, or haemorrhagic states. A cold bath is a tonic procedure. continuous tepid baths.—Patient’s body is greased with lanolin or vaseline. He is then placed in a tub of water at 94° F. to 98° F., suspended in a hammock- like arrangement. Rubber pillows support the head and buttocks. The water is kept at the desired temperature, preferably by thermostatic valves. It is used from a few hours to days or weeks to quiet nervous conditions, treat sup- purating wounds, burns, and extensive skin lesions. hot baths are full tub baths given at temperatures from 100° F. to 108°F. Start at body temperature and quickly raise the temperature after the patient is immersed to the chin. Continue for from 10 to 20 minutes, dry the patient and give an alcohol rub. Hot baths increase elimination, metabolism, and give some relief to muscle spasms. They were often used in arthritis and rheumatoid conditions until the electric light cabinet superseded it in most institutions. hyperpyrexia baths.—Patients are immersed in a tub of water at 110° F. (starting at body temperature). Ice is applied to the head and neck. The body temperature may reach 104° F. in 20 minutes. The water is then lowered to 105° F. and the body temperature is kept at this degree for 45 minutes to 1 hour. Patient may require considerable nursing. Reduce temperature to 922 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY normal by cooling the bath and follow with rest in bed. Baths are to be administered 1 to 3 times a week for 10 to 20 times. hip and sitz baths.—A local bath that may be given in any tub not over a foot high. In most institutions, specially built tubs support the back and arms. The water should cover the umbilicus. Short cold sitz haths with water at 65° F., given for a few mimites with vigorous friction of the abdomen, result in a strong stimulation of the abdominal muscles and tissues. The hot sitz hath with water at from 110° F. to 115° F., is given for 15 minutes. They cause relaxation of abdominal pain and spasms and are also used for prostatitis and haemorrhoids. contrast baths cause an intense vasomotor stimulation of the hands or feet. The part to be treated is placed in hot water at from 105° F. to 115° F. for 1 minute; then in cold water for 1 minute, and repeated 7 to 15 times, followed with massage and motion. The part should he immersed in hot water last. These baths are used in circulatory disturbances of the extremities; chilblains, trench feet, wounds, scars, amputation stumps, and foot disabilities. For shoulders, knees, and other parts of the body contrast baths may be given by using a hot spray for 5 minutes and then a cold spray for 1 minute; then a hot spray for 1 minute and cold spray for 1 minute. Continue changing at 1 minute intervals for 15 to 20 minutes, and always end with hot spray. pakaffin baths are used to apply intense local heating to the skin. The skin is covered with hot molten paraffin and soon becomes encased in a solid nonconducting cast, which keeps up the temperature of underlying parts for a long time. Method of use.—Obtain about 3 or 4 pounds of paraffin, or “jelly wax” as it is commonly called, and melt it in the top of a double boiler until it is liquid. Then let it cool until a thin, white coating appears on the top when it is ready for use. When applied to the hands, the hands are dipped in and out, without moving the fingers, until several coatings are applied. Then let the hands remain in the wax for 20 minutes, take them out and peel off the wax. To apply to other parts of the body (knees, shoulders, elbows, back, etc.) obtain a wooden paddle or a wooden cooking spoon. Wrap several thicknesses of cloth around it, tying them on. Dip this in the wax and paint a coat over the entire area to be treated, until the part is completely covered. Then paint 10 to 12 coatings on top of this. Cover with a towel or blanket and leave on for 20 minutes. Then peel off the paraffin and the part is ready for further treatment. Paraffin baths are useful in after treatment of fractures of the bones of the wrist and hands, stiffness of joints following lacerations or infections, scar tissue restricting motions of joints and tendons, weakness or stiffness of hands secon- dary to nerve lesions associated with fractures, or other lesions of nerve trunks. Hydrokinetic Measures consist of douches and showers, showers are in common use by many people and have a strongly invigorating effect, but must be used cautiously in the weak and ill. douches are administered from a con- trol table (fig. 179), usually with two nozzles and appropriate mixing valves for temperature control. Valves for pressure control and thermometers and pres- sure gauges are on each nozzle. Rain showers (from overhead) affect the shoulders and head. The circular or needle douche is arranged with outlets around the shower cabinet so that by turning, the entire body is in contact with many fine jets of water. This shower can be used at constant temperatures, or by alternating hot and cold several PHYSICAL THERAPY 923 times. Is mildly stimulant to circulation and metabolism and is of value in nervous and functional heart conditions. Jet douches are applied from the control table, with a solid stream of water. In fan douches the tip of the finger is held over the nozzle tip to fan the stream, thus creating mechanical stimulation. A constant hot or cold douche or an alternating hot and cold douche (Scotch douche) is used with the patient facing the table, 10 to 12 feet away. The jet is applied slowly from the feet up to the shoulders and down again, with the same application over the back, for 2 to 4 minutes; the patient should then quickly dry and dress. Allow reaction to occur and repeat several times. Do not overtax patient’s reactive power. Figure 179.—Hydrotherapy apparatus showing: a, control table; h, arm whirlpool; c, leg whirlpool; d, sitz bath; e, needle spray; f, shower. Whirlpool Baths are batlis in which water at 110° F. to 115° F. is kept in agitation in a vessel which will hold an arm or leg. This has the advantages of heat and the gentle mechanical effect of whirling water. In 15 to 45 minutes the skin becomes pink, inflammatory induration is softened, pain and spasm relieved, repair of wounds stimulated, and the removal of necrosed tissue and pus speeded up. They are used for the stiffness, pain, and sluggish skin circulation following fractures as soon as immobilization can be removed. Painful scars, adhesions, peripheral nerve injuries, some forms of arthritis, indolent chronic suppurating wounds, painful stumps, weak and painful feet respond very well to this treat- ment. They are used as a preparation for massage and electrical therapy. Thkkapkutic Pools and Tanks.—Under-water medical gymnastic exercises lake advantage of the buoyancy of water for the reeducation of feeble and flabby muscles. The temperature of the water is also beneficial, and in outdoor pools the sun and fresh air are of aid. Salt will increase the buoyancy. Their greatest use is in treating victims of poliomyelitis, but it is also used in spastic paralysis, multiple sclerosis, chronic arthritis, post-operative bone cases (espe- cially back and hip cases), scoliosis and postural spine deformities. The usual 154294°—39 59 924 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY temperatures are 97° F. to 100° F. for spastic states and sensitive muscles, and 86° F. to 92° F. for other chronic conditions. A large bath tub may be used for children and special tanks are often con- structed. The usual hospital pool is 10 x 15 feet with a depth of 2 to 4% feet. The floor is of non-skid material; easy steps are necessary and often hoisting devices are provided. Hand holds, choirs, and various floating supports are necessary. LIGHT THERAPY AND ELECTROTHERAPY The methods used in light therapy and electrotherapy may be considered sim- ply as the application of energy which is obtained from a number of sources and has various wave lengths, with corresponding frequencies of wave oscillation. The various wave lengths vary markedly in their effects on the human body and are measured usually in Angstrom units (abbreviated A", or A. U.) the length of one unit being )4o,ooo,ooomillimeter. The electromagnetic spectrum extends from the cosmic rays which have a wave length of 0.001 to 0.01 A. U., are generated in intrastellar space and are of no known therapeutic use, through the gamma rays of radium (0.01 to 1.4 A. U.) X-rays, ultraviolet, visible light, infrared or heat rays, to the long and short Hertzian waves. The latter waves include the length used in diathermy (300 meters), short wave diathermy (30 to 3 meters), and the extremely long waves used in radio transmission. Light therapy consists of the therapeutic application of radiant energy. Radiation is the process by which energy is propagated through space. A light ray consists of an enormously large number of exceedingly small entities trav- eling through space at a speed of 186,000 miles per second. The clinician tests the length of the waves he uses by their skin effect, and for other methods he relies on the manufacturer or physicist. Luminous sources.—Infrared and luminous radiations are long wave, or far infrared rays, such as are radiated from hot-water bottles and electric pads and do not penetrate deeper than 3 mm. in the skin, and short wave, or near infrared lays, which are supplied by the sun, carbon arc lamps, incandescent lamps, and specially built infrared generators, and penetrate 10 to 30 mm. to the subcutane- ous tissue. The most common luminous sources are incandescent filament radi- ators, electric light bulbs with tungsten or carbon arc filaments, with reflectors. A wattage of from 150 to 1,500 may be used but the penetration is the same. These lamps produce 95 per cent infrared rays, 4.8 per cent visible radiation, and 0.1 per cent ultraviolet rays, the latter being absorbed by the glass. “Bakers” are provided with several small (60 watt electric) light bulbs in cradles, and if necessary can be built by any tinsmith. Nonluminous sources.—A heating element mounted in the center of a portable reflector is heated by an electric current to a dull red, and the reflector distributes heat on the body evenly. They are similar to bathroom heaters and are only skin warmers. The local effect of light therapy is nearly immediate, and shows as a reddening of the skin which lasts from 10 minutes to an hour. The active hypenemia re- sults in better circulation, better nutrition, increased removal of wastes and increased resistance to infection. Overdoses cause deep burns. Small amounts are sedative, large amounts are counterirritant. The effects of general irradia- tion are profuse perspiration, rise in pulse rate, lowering of blood pressure, in- creased respiration, increased elimination from kidneys, and sedation. Clinical useis.—Light therapy is beneficial in contusions, muscular sprains, traumatic synovitis, sprains and dislocations, fractures in accessible locations (not in the first few hours), arthritis, rheumatoid conditions, neuritis, neuralgia, PHYSICAL THERAPY 925 acute, subacute, and chronic catarrhal conditions in accessible areas, as con- junctivitis, sinusitis, nonsuppurative otitis media, and bronchitis. If used early in head colds it will often abort them. It is also of value in folliculitis and furunculosis, and to warm antiseptic dressings in cellulitis, etc. For this purpose it has the advantage of even heat, no pressure, and does not disturb the patient. Light therapy is used to warm the skin before diathermy, galvanism, massage, etc. Technique.-—The patient is made comfortable and the generator directed over the part to be treated, at a comfortable distance, usually 2 to 3 feet. A 10-minute treatment is given to warm the skin, one-half to 1 hour is used for other treat- ments. Repeat daily or oftener, depending upon acuteness of cases and the progress. Precautions.—Never make the patient uncomfortable. Use 1V2 times the nor- mal distance for anaesthetic areas. General heat radiation is used for selected cases of arthritis, nephritis, early active sclerosis, obesity and toxaemias, and often in combination with hydro- therapy. Electric light baths.—A wooden cabinet, large enough for a patient to sit in with the head protruding, containing a number of light bulbs is used. The patient is undressed, seated, the box closed, and the lights turned on. An ice bag is applied to the head. The patient is never left alone, and the treatment is stopped if he becomes faint. For tonic treatments use 5 to 8 minutes; for elimi- native, use 8 to 15 minutes and give water with salt to replace that lost by per- spiration. Follow with a tepid shower. For bed patients, a large heat cradle may be used. Ultraviolet radiation.—The chief natural source of ultraviolet radiation is the sun. Of artificial sources the electric arcs between electrodes of metal, of carbon, and of mercury in quartz are used. The range of radiant energy desig- nated ultraviolet is from 3,900 to 1,800 A. U. and is divided into “long ultra- violet” rays extending to 2,IKK) A. U., and short ultraviolet rays of 2,900 to 1,800 A. U. Sunlight contains less of the shorter rays. Quartz permits the passage of ultraviolet rays to 1,800 A. U., air up to 1,850 A. U., but dirt, smoke and dust filter out more. Ordinary window glass only permits passage of waves over 3,200 A. U. Human skin stops all ultraviolet rays, and even paper-thin clothing arrests most of the radiation. The biological effects of sunlight are to increase the regeneration of red blood cells, to stimulate the formation of white blood cells, to increase resistance to some infections, to increase the calcium and phosphorus content of the blood serum, and to stimulate all metabolic processes. clinical uses of general ikradiation.—The range of about 3,000 A. U. is curative in rickets. It is useful in bone and joint, lymph node, and genito- urinary tuberculosis, and as an adjunct to the treatment of general debility, secondary anaemia, convalescence, chronic bronchitis, asthma, and selected cases of neurasthenia. Local irradiation is most nearly specific in lupus vulgaris and erysipelas. It is of value in many dermatoses, sluggish healing wounds, indolent ulcers and chronic osteomyelitis. Also in the treatment of chronic catarrhal condi- tions of the upper respiratory tract. Sterilization of infected areas in carriers of cerebrospinal fever and diph- theria is often obtained after treatment with quartz rod applicators. contraindications.—Ultraviolet irradiation is dangerous in active pulmo- nary tuberculosis, advanced cachexia, heart diseases with failure in compen- sation, advanced arterio-sclerosis, and gross renal or hepatic insufficiency. Annoying skin and general reactions may occur in diabetic and hyperthyroid 926 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY patients, and a generalized dermatitis as a rule is a contraindication. Photo- sensitization is a condition in which certain drugs, endocrine products, and heavy metals in the blood increase the effects of radiation. Check such cases with a subminimal application first. Heliotherapy.—Usually sunlight contains 60 per cent infrared and 40 per cent invisible and ultraviolet radiation (never below 2,900 A. U.). At higher altitudes the ultraviolet increases at the expense of the infrared. The season, climatic conditions, and hour of the day influence the amount of ultraviolet radi- ations reaching the earth. The greatest antirachitic effect is produced in the summer at noon. The effects of heliotherapy are produced by the blending of infrared, luminous, and ultraviolet radiations, as well as the usual nursing care used. The sun rays produce a pigmentation of the skin, an increase in gen- eral tone of muscle and skin, and a general euphoria with a lessening of pain and fatigue. technique.—Heliotherapy can be practiced anywhere, except that sufficient sunshine and clearness of atmosphere are prerequisites. The best hours in the summer are from 7 to 11 and in winter from 10 to 2. On the first day expose the feet 5 minutes; on the second day expose legs 5 minutes and the feet 10 minutes, and by similar exposures include the whole front of the body in 5 days. Then on the sixth day expose the entire back for 5 minutes. Gradually increase the amount of exposure each day, but stay under dermatitis doses. Young adults, for tonic purposes, use 8 minutes to 4 surfaces (two divisions of the front and back) the first day, and increase the time 5 minutes daily. Babies 6 to 8 months old may start with y2 minute on the back and y2 minute on the front, and may increase the time of exposure 1 minute daily until 6 min- utes are reached, front and back. Heliotherapy should not be given if headaches, restlessness, elevation of the body temperature or of the pulse rate are present. Ultraviolet transmitting windows are not at present practical except in special hospital solaria. Artificial ultraviolet therapy.—Carbon arc lamps consist of two carbon electrodes held in the lamp so that their free ends touch and are connected with a source of current. The current is started and the ends separate; the current continues to flow, striking an arc and producing an intense illumina- tion. The radiation varies, depending on the carbon used, and the strength of (lie current. Radiation is emitted from the hot tips of the carbons and the arc itself. In general, mercury vapor lamps are more satisfactory. quartz mercury-vapor lamps are often designated as hot and cold. Hot quartz lamps.—The principal part is the burner, a fused quartz tube, air-exhausted and containing mercury. The air-cooled lamps are mounted on a stand with a reflector and are used principally for general irradiation. In the water-cooled lamps the burner is surrounded by a water jacket with inflow and outflow pipes for cold water, and a window at one side for radiation after the heat has been absorbed. This type can be used in contact with the skin, and with suitable quartz rods, for an orificial application. To operate, the water is started, the current is turned on, and the burner tilted slightly until the mercury runs across the vacuum and completes the circuit. The heat generated vaporizes enough mercury to fill the tube and the vapor conducts the current. Ten minutes should be used to build the tube up to maximum capacity of radiation. All quartz burners deteriorate with age so erythema checks should be made frequently to determine the correct dosage. PHYSICAL THERAPY 927 Cold quartz lamps.—The radiating source is a fused quartz tube, highly evacuated, but containing rare gases (argon, xenon, and krypton) and a few drops of mercury. The tube is shaped in the form of a hexagonal grid for general irradiation and mounted on a large aluminum reflector. Alternating current is stepped up to 2,500 volts with low amperage (15-25) and a high voltage flow is provided in the tube. Emission takes place as a glow discharge. Full strength is obtained in about a minute, with 95 per cent radiation at 2,537 A. U. These lamps are proving very efficient. Electrodeless high frequency induction lamps.—The radiating surface is a round bulb of quartz or corex—a glass which is evacuated and contains a tiny drop of mercury. The bulb is surrounded by a high frequency coil attached to a transformer of a diathermy machine. A current of 5,000 volts from the secondary brings the vapor of the mercury in the bulb to full luminescence in 30 seconds. The bulb remains cool, and does not deteriorate. Special appli- cators are made for all cavities of the body. Tungsten filament bulls of sun-lamp type.—A pyrex glass bulb filters ultra- violet rays shorter than 2,800 A. U. The bulb has a U-shaped tungsten fila- ment and a small pool of mercury. Fifteen minutes application (average) gives a mild sunburn at 24 inches. A transformer is needed to operate these lamps in the usual house circuit. technique of genebal ibradiation.—The entire body is exposed and recum- bent. Protect the eyes with dark goggles. Cover the genitals and face with a thin towel at first. In adults divide the front and back into 2 halves, giving 4 fields for treatment. Dosage.—Each lamp must be calibrated for itself. A standard distance, as 30 inches, is best used. Cover forearm with paper with 3 dime-sized holes. Expose each for a different time, as 1, 3, and 5 minutes. In a few hours one should show a first erythema reaction which is the erythema reaction time of the lamp. Begin treatments at the standard distance, with tested erythema exposure time. Slowly change the time to 15 minutes, 2 minutes at a time (hot quartz lamp) then lower the lamp 2 inches at each successive treatment to 18 inches, 48 hours apart, but irritative doses are never applied except to small areas. No treatment should be repeated until reaction from the previous treatment has disappeared. People of fair complexion, blondes, young children, and old people are more susceptible to the erythema-producing radiation than adults of the dark type. A safe routine is to give, for an initial dose, the aged one-half, women three-fourths, blondes and redheadheads one-third to one-fourth the average dose. The most sensitive areas in order are the face, chest, abdomen, back, sacral regions, arms, legs, hands, and feet. local irradiation.—The area to be treated must be cleaned of all grease, oils, etc., preferably by ether. For burns and clean granulating tissue give a mild erythema daily. For suppurating areas and old skin lesions use intensive dosage, as 4 minutes at 15 inches. From a new air-cooled mercury lamp this should pro- duce a marked dermatitis (third-degree dermatitis). This treatment can be re- peated every fourth or fifth day. In erysipelas very intensive dosage, 20 times erythema has been given. For counterirritation in neuralgia, myositis, etc., give second and third degree erythema doses. In applying ultraviolet therapy to mucous surfaces with quartz-rod applicators, about double the usual skin dosage may be used. Clinical estimation of dosage.—Sub-erythemal—no visible reaction ; first degree erythema (tonic dose), administered over entire body or large area, skin redden- 928 HANDBOOK OF THE HOSPITAL COUPS, U. S. NAVV ing very slight, and disappears in 1 or 2 days with no trace; second degree erythema (stimulating dose) mild reaction, followed by slight desquamation that subsides in 3 days and may leave pigmentation; and third degree erythema (bactericidal dose or destructive dose) intense reddening after 2 hours, and blis- tering, persists for many days and leaves deep pigmentation. TYPE OF CUEHENT MODE OF FLOW APPROXIMATE FREQUENCY VOLTAGE AMPERAGE PHYSICAL EFFECTS AND USES COMMON 30UBGE Galvanic. Uhidirection- al; constant Low Medium Mild thermal. Chemic- al :(+) acid, hardens tissues; (-) alkaline, softens tissues. Both poles; Vasomotor stimulation, promotes nutrition and relief of Inflammatory condi- tions, and contusions, Ionic medication; surgical-. Motor gener- ator as Morse. Interrupted galvanic. Unld al ire urg ct . lc n- Up to 100 per second. Low Medium Mild thermal. Chemic- al: Alternating acid or alkaline. Dynamic: Motor and sensory stimulation. Muscle testing. As above and break key. Slow (Gal- vanic) sinusoidal. Slow alter- nating waves. A A 3 to 9 per minute. Low Medium Stimulates smooth and skeletal muscle In flaccid paralysis. Motor gener- ators. Interrupted or modulated alternating galvanic. V/ V/ Rapid alter- nating waves. A dill Up to 180 per second. Low Medium Graduated contractions in non-paralyzed muscles. Motor gener- ators. w 1 W Farad1c. Hapid alter- nating asy- metric. JVJU 00 to 100 per second. Medium Low Ele ctro-dlagnos1s. Faradlc coil, as Bristow coil. Faradlc surged. Above surged ill i\ VI A A 100 per second. Medium Low Graduated exercise without tetany. Motor driven device in ' a 1 ) High fre- quency, (damped)• Extremely rap- id alternating oscillations. 1,000,000 High High ' Thermal: Increased circulation, sensory and motor sedation. Bactericidal. Relief of spasm and pain. Conven- tional Diather- my. Promotion of nitri- tion and absorption. High fre- quency, (un- damped ) Short and wave dia- thermy. Extreme rapid a nat ing oscilla urn iy Iter- tions mi 1 Over 2,000,000 oscilla- tions per second. High High Profound thermal. Keating tissues. Hyperpyrexia. Cutting current. High fre- quency , undamped apparatus. Figuue 180.—-Currents used in electrotherapy. Electrotherapy is the treatment of disease by means of electricity in the form of different kinds of electrical currents derived from various sources. Figure 180 shows the currents used in electrotherapy. 929 PHYSICAL THERAPY The galvanic current is a unidirectional and constant current of low voltage (2-100) and low amperage (1-50). It is obtained from wet or dry cells, from direct current mains with rheostat control, or from an alternating current supply changed to direct current by a motor generator or valve tubes. It is used: 1. To treat acute and chronic traumatic and inflammatory conditions, as contusions, spasms, or myositis; 2. For ionic medication in selected cases of arthritis, neu- ritis, neuralgia, and rheumatoid conditions; 3. As part of the follow-up treatment of selected cases of cerebral haemorrhage; and 4. Surgically, in the treatment of benign new growths, superfluous hair, and dilated blood vessels. Technique.—The polarity of the galvanic current can be determined by dipping two metal electrodes from the apparatus in a bowl of salt solution. Bubbles arise from the negative pole. The electrodes, metal plates covered with a well moistened pad (16 thicknesses of gauze) of the size and shape of the area to be treated, are applied firmly. If the electrodes are of equal size the polarity effect may be ignored, if unequal, the polarity effect will be more marked at the smaller electrode. Warm the skin first. Turn the apparatus on gradually, opening the rheostat until the desired cur- rent is obtained. If patient complains of burning, reduce the current, or turn the current off and remoisten and rearrange electrodes. Current within com- fortable tolerance of patient, % to 1 milliampere of current per square inch of electrode surface. Treatments are usually given for 15 to 20 minutes, on alternate days, or started at 7 minutes and gradually increased to 40 minutes. In cerebral applications the patient is recumbent, and two electrodes, 2 inches wide and 4 inches long, well secured at the forehead and nape of the neck, are used. The negative pole is at the forehead. The current must be constant, with no sudden changes, and started slowly at 1 milliampere and increased to 2 to 5 milliamperes daily or on alternate days. This treatment is used in post-hemiplegic conditions. Galvanic baths are given in wooden or porcelain tubs, with two electrodes in wooden frames to prevent direct contact with patient. The current is turned on gradually to comfortable toleration, 500 to 200 milliamperes for 10 to 15 min- utes. These baths cause general muscular stimulation, acceleration of metabo- lism, and are of value in generalized arthritic conditions, extensive paralysis, and neurasthenia. Ionic medication.—A large dispersive electrode is applied to a convenient part of the body and the active electrode over a pad well moistened in the therapeutic solution is placed over the area to be treated. Current to comfortable tolerance is used for one-half hour. The following table gives information concerning sub- stances used in ionic medication: Drug Active electrode Use Time Sodium chloride, 1% solution— Iodine, 1% solution Salicylic acid, 1% solution Quinine, 1% solution . Negative pole. do - ___do Positive Soften scars Goiter; chronic synovitis.- Resistant arthralgia Trigeminal neuralgia... Circular anaesthesia Vi hour daily or alter nate days. Do. Do. Do. Do. Pew minutes. Do. 20-30 minutes. Comfortable (10) totol eration (30). Lithium ions, 1% solution Histamine (acid neoplate), 1 to 1,000 solutions. Cholin, H to 1% solution Zinc chloride or zinc sulfate, Vi% solution. do ---._do do do Gout Myositis; rheumatical condition, chronic. Periphera vascular processes Indolent ulcers; chronic otitis media. 930 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVA Interrupted galvanic current is produced by a mechanical device placed in a galvanic circuit that interrupts the current flow at regular intervals. This cur- rent causes muscular contraction beginning at the cathode on “make” and con- traction beginning at the anode on “break” due to the chemical stimulation produced by the current. It is used for muscle testing and occasionally in cases of paralyzed muscles that will not respond to other currents. It also causes a sensation of pain at the sensory nerve endings in the skin. Faradic current is produced by an induction or faradic coil. The intensity is regulated by varying the relation of the secondary and primary coils. This current produces a tetanic contraction of all muscles supplied by the motor nerve stimulated. It is seldom used except for electrodiagnosis because it is quite painful. Surging Faradic Current. A motor-driven device “surges” the faradic cur- rent by interposing varying resistances in its path and allows the use of this current for stimulating weak nonparalyzed muscles without painful tetanic contractions. In the Faradic Vacuum-tube Current 120 short unidirectional impulses per second are produced by vacuum tubes; this current is nonpalnful. The Slow (Galvanic) Sinusoidal Current is a galvanic current passed through a rythmically varying resistance which at the same time periodically reverses the direction of flow of the current at the rate of 5 to 30 alternations per min- ute; it stimulates smooth and skeletal muscles in flaccid paralysis without pain- ful contractions. The Surging and Interrupted Sinusoidal or Modulated Alternating Current is a current with a more rapid alternation and surging, or rise and fall, than the slow sinusoidal, and which is well tolerated. It effects graduated contrac- tions in nonparalyzed muscles. For simple muscle stimulation the patient should be comfortable and the muscles warmed and relaxed. Place a large dispersive electrode (3 by 4 inches) over the sternum or spine and a small active electrode 3 inch in diameter over the belly of the muscle. Moistened pads are used under the electrodes. Clinical uses : In cases of weak muscles with no organic nerve involvement use the surged forms of faradic and interrupted modulated forms of alternat- ing current with 50 to 100 alternations per second. The first stimulation should be weak, the second stronger, and the third still stronger. Rest, and repeat sev- eral times but avoid fatigue after treatment. Tremor in the muscle indicates too much current, or too long stimulation. Use voluntary exercise as soon as practicable. For group stimulation use the surged currents 5 to 10 minutes daily. Place the electrodes at the ends of the extremities, as at the sole of the foot, and under the buttock. Such currents are of especial value in disuse atrophy and are used for sprains, strains, contusions, hsematoma, adhesions, myositis, tor- ticollis, lumbago, atony of abdominal muscles after childbirth, and various joint adhesions. In the electrotherapy of flaccid paralysis the purpose is to retain some of the contractile power of the muscle until nerve function returns. The choice of currents is the slow (galvanic) sinusoidal. Place the dispersive elec- trode over the cervical or lumbar spine and the active electrode directly over the muscle. Great care must be used to avoid overfatigue of these very weak mus- cles. Start with 3 to 10 contractions, and only a flicker of motion at the ten don is necessary. Treat for 2 to 3 minutes, and gradually increase to 30 to 40 contractions for 15 minutes. Sometimes the interrupted galvanic current must be used to get a response. The treatment must be combined with muscle train- ing, as is necessary after hemiplegia. For spastic paralysis use the surged or PHYSICAL THERAPY 931 interrupted alternating current only as an adjunct to muscle training and re- education. Electrodiagnosis deals with the reaction of muscles and motor nerves to elec- tric stimuli and is a valuable aid in the diagnosis, prognosis and therapy of pathological conditions of the motor tract, Including the brain, spinal cord, and peripheral nerves and, also, of the muscles. In faradic testing, a faradic coil, activated by a galvanic (direct) current is used. The patient is placed comfortably in a well-lighted room. The muscles to be tested are warmed and relaxed. In unipolar testing place the large dispersive electrode any place where there is little muscle tissue, as over the sternum or sacrum. Using the faradic current set the active electrode over the motor point of the muscle or nerve to be tested, turn on the current with about 2 to 3 cm. on the secondary coil scale. Press the key of the interrupting handle and start the current flow. Change the coil until the lowest setting is obtained that gives a response. With the galvanic, use the negative pole for the active electrode and advance the rheostat slowly, pressing the key down from time to time to get the minimal response. In testing with condensers use a technique similar to that used in galvanic testing. Various strength condensers are used consecutively for the test, and it gives an accurate measurement of the current needed. It is mainly used to indicate progress in infantile paralysis. Reaction of Degeneration (abbreviated R. D.) indicates damage to the nerves, muscles, or both, and is shown when the response elicited is of a different type, and is elicited by a different current strength than under normal conditions. Standard texts must be consulted for full details of electrodiagnosis. High frequency.—The essential source of high frequency currents is a supply of alternating current raised to a high voltage by electromagnetic induction (transformer). This high voltage current charges a set of condensers which discharge across a multiple spark gap. The spark discharge sets up oscillations of fairly well sustained damped (impeded) character at a rate of several hun- dred thousand to over a million a second. The high frequency current thus pro- duced is conducted to the patient from the terminals of the apparatus by suitable electrodes and conductors. Most high-frequency machines also contain an Oudin coil, which produces a very high-voltage current (Oudin current) which is led off a single terminal. To operate a high-frequency apparatus turn on the main switch with the rheostat closed, allowing no current to flow to the transformer. Have spark gaps closed or slightly opened. Then open rheostat until the desired current is obtained. A pleasant treatment results when the rheostat is slowly opened and the spark gaps adjusted in balance. The milliammeter usually reads from 100 to 2,500 milliamperes, or if two are used, a high (1,000 to 4,000) and a low (100 to 1,000) is usual. Diathermy apparatus of vacuum (thermionic) tube type is a more modern development of high-frequency apparatus and produces undamped oscillations of stable and efficient character through use of the three element or amplifier tube of DeForest. Effects.—The rapid alternations do not produce sensory or motor effects as obtained with low frequencies. Heat is produced depending on the strength of the current, the resistance of the tissue, and the length of the treatment. Secondarily, an active arterial hypersemia is produced, and metabolism is increased. Little permanent change in blood pressure results. A definite sedative effect is produced. 932 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Clinical Uses.—High frequency currents are used for traumatic or inflam- matory changes in joints, bursae, and bones, chronic inflammation of intes- tinal organs, all chronic gonorrhoeal infections, congestive lung conditions, neuritis, neuralgia and circulatory disorders. Contraindications.—In general, any condition in which simpler heat is as effective. Specifically in acute inflammatory conditions with fever and sup- puration, and also in conditions with tendency to haemorrhage (as haemoptysis). Technique.—Block tin, gauge 22, is cut and molded to fit the part. If it is smooth and gives perfect contact, no soaping, etc., is necessary. Warm the skin slightly before applying. Bandage or sandbag to hold firm. The transverse or through and through method is the common method. Two electrodes are placed on opposite sides of the part to be treated. If the electrodes are of equal size and the part thickness is not over 1% times their greatest diameter there will he equal heating through the part. If the part is thicker, larger electrodes must be used. When unequal size electrodes are used, the smaller gets the most current and heat, and so can be used to heat a small superficial spot. In the longitudinal or cuff method two bent or cuff electrodes, placed fully or partly around an extremity, heat superficially. They must be 10-15 inches apart and the limb must be straight if the cuff goes completely around. Dosage.—A comfortable sensation of heat only should be felt by the patient. This should occur when a current of 70 to 100 milliamperes per square inch of active electrode, if it is not a cuff or over 4 inches square, is used. About 1,200 to 1,500 milliamperes may be used for 4 by 6 inch electrodes. Twenty minutes is the average time used for a treatment, on daily or alternate days, depending on the progress, although in some conditions a longer treatment may be advisable. Safety Rules.—Electrodes must be in absolute skin contact to avoid burns. See that skin is unbroken and sensation normal. Instruct patient to report any uncomfortable sensation, as prickling or burning. Open main switch, open rheostat gradually, and then the spark gaps. Raise current slowly. Mod- erate heat Is better over a longer period, than high heat over a short period. Check all uncomfortable complaints of the patient. Never leave a patient. Watch the milliammeter for an even flow of cur- rent. Stop treatment by turning switches in reverse order. Inspect electrode site. Cool patient before leaving department. Monoterminal High Frequency.—The Oudin current is applied through glass vacuum or non vacuum (condenser) electrodes. In close contact for a long time it produces a mild heating. When the electrodes are moved with slight contact to give sparking, a mild counter irritation is produced. It is used in neuralgia of skin nerves; and in post- operative scar neuralgias (10 minutes, mild sparking). When applied for 35 minutes with fairly vigorous sparking, it acts as a counter irritant in deep seated pain. A mild sparking is used for sluggish ulcers, anal fissures, etc., and close contact for functional neuroses. High-frequency Saturation is a modification of the monoterminal treat- ment. The patient holds in his hands a vacuum tube which is connected with the Oudin terminal. Diathermic massage can be performed while the patient is in contact with this current. A mild sedative effect is produced. For General Diathermy large trunk electrodes are applied for 1 hour with a current of from 1,500 to 3,000 milliamperes. A temperature of about 100.6° F. and sweating is produced. It can be used on alternate days for a week in 933 PHYSICAL THERAPY general circulation disturbances, as mild arteriosclerosis, and general neuresthenic conditions. In Autocondensation a current of 500 to 1,200 milliamperes is applied through a large body electrode, (a special chair or a large trunk electrode under a hair mattress) and a second electrode in direct body contact. Usually a metal bar is held in the hands. A mild heating effect and a general sedative effect is produced. It is most often used in hypertension. Short-Wave Diathermy is the newest development of high-frequency cur- rents in therapy. It is divided into two fields, short-wave diathermy, using 12 to 30 meter (M.) waves, (10,000,000 to 25,000,000 oscillations per second) and Figure 181.—Diathermy apparatus. A, foot switch plug, for use with surgical attach- ments ; B, plug for electric current main ; C, dial, power control; D, dial, milliammeter in power “input” circuit; E, plate switch, to be turned on after filament switch ; F, filament switch; G, dial, resonance control; H, dial, milliammeter, in patient’s circuit; I, jacks for electrode or surgical electrodes; J, electrode; K, sponge rubber to separate the electrode from the skin. Note that electrode cables do not touch the patient or each other. ultra short-wave diathermy with waves below 12 M. (over 25,000,000 oscillations per second). It may be produced by vacuum tube oscillators, or by spark gap apparatus, but for practical reasons the tube apparatus is commonly used. An alternating current is passed through a stepup transformer to usually two rectifier tubes, and two oscillator tubes, combined with suitable inductance and capacity. Oscillations are transferred to the treatment circuit, and treatment plates attached to the ends of the circuit form condensers. A variable con- denser or variable self induction is placed in the treatment circuit to bring the capacity of the patient into resonance with the main oscillating circuit. This is varied by the resonance control on the apparatus and when in resonance the highest output of the machine is obtained, and the highest reading is shown on the milliammeter. The oscillations are undamped. One type of apparatus is shown in figure 181. 934 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY The Mode of Heating differs from diathermy in that heating depends not on tissue resistance but on dielectric hysteresis, i. e. the heat) generated by the friction of the rapid motion of the tiny particles comprising the body dielec- trics in a very rapid oscillating condenser field. In the short wave field the therapy effect is the same, regardless of the wave length, and it can be applied to all conditions in which diathermy has been used, or in which heat is indicated. Selective effects have been claimed for ultra-short diathermy. Technique.—Condenser electrodes consist of flexible metal, covered with thick pliable rubber, with a suitable cable to connect with the jacks on the machine. They are made in various sizes, and special applicators are made for localized uses, as for sinuses and various body orifices. It is necessary that an air space be provided between the electrodes and the skin. Glass electrodes are made that incorporate definite skin (air) spacing in their construction, but for usual techniques rubber pads, felts, or folded towels are used. Four thicknesses of bath toweling gives a satisfactory spacing, and absorbs all perspi- ration from the skin. This is important in avoiding skin burns. The depth of heat effect is greatest with the greatest skin distance, and the heat effect is greatest on the skin when the electrodes are closest. The usual distance is 0.5 to 1.5 inches but for ultra short waves 2.0 inches is necessary. The elec- trodes or applicators should be of equal size, unless a heat point is desired, and spaced equidistant from the skin. If not, the closer pad concentrates the heat. Bach applicator must be equidistant at all points from the skin to avoid “hot areas.” This is very important over bony prominences, as the shoulder. With the electro-magnetic type of apparatus a coil is provided that is wrapped around a part, looped over it or coiled “pancake” over the area to be treated. The coils should be close together, and as near the skin as is comfortable. In general, the size of the applicator depends on the area to be treated, for thick parts large electrodes well separated from the skin are used, to reduce the skin heat sensation and supply more energy. One may be used (unipolar) especially in treating conditions in which through and through heat is not wanted, as boils, the nasal sinuses, the middle ear, etc. (the other electrode must be connected to the machine). In general an electrode is placed on each side of the part to be treated, avoiding bony prominences as much as possible. They may both be placed on the same surface, but not too close together. The distance depends on the current used, and the size of the part, but not less than 6 inches. For pelvis heating, long narrow electrodes that encircle the body (36 by 6 inch “cuff electrodes”) are used above and below the parts, or one in combination with a smaller “point heating” electrode. This may also be applied over the length of a limb. With large electrodes body temperature will be raised, so care to avoid chilling is necessary. The electrodes must be held in position with bandages or sandbags, but never put weight directly over a bony prominence. Place the electrodes, patient’s skin exposed, turn on the filament current, the plate current, and adjust the resonance control to maximum reading, with power control (if one is provided) low. Wait for the sensation of heat by the patient; if too warm, turn back power and then resonance if necessary. If not warm enough increase power. The one reliable guide to intensity of treatment is the patient's sense of heat. Do not disregard complaints of too much heat, and instruct the patient carefully to report uncomfortable heat before begin- ning the treatment, for severe burns can occur. The milliammeter reading indi- cates a flow of current, but does not show the heat being applied, or generated in the tissues. This reading will change with any change in position of the electrodes, of the patient, or even because a person comes into the vicinity of the field. Care must be used in treating anaesthetic areas. A sense of com- PHYSICAL THERAPY 935 fortable heat is obtained and maintained. Pain in an extremity usually means too much heat, probably due to periosteal irritation. In pneumonia short-wave diathermy is given by through and through electrode application over the affected side of the chest, or the electrodes may be placed parallel over the chest to avoid disturbing the patient. Forty-five to sixty minutes, otjce or twice daily. Advantages.—Short-wave diathermy facilitates the treatment of regions to which it is hard or dangerous to apply diathermy, and permits use of simpler and more stable apparatus; plates are not applied directly to the skin; permits a simpler and more flexible technique; provides a more effective method of applying heat; and is safer than diathermy with comparable precautions. Dangers.—Severe burns can be produced by overheating and improper elec- trode spacing. Inductotherm.—A vacuum tube oscillator generating approximately 26 M. waves, is used to charge a cable which is applied around, about, or over a part to be treated. Heat is produced by electro-magnetic induction in the tissue, from the rapid oscillating cable current. Is an efficient source of diathermic heat, and is capable of producing hyperpyrexia. Ultra Short-wave diathermy uses any wave length belowT 12 M., and 6 M. apparatus is in common use. Technique and indications are similar to short wave but greater spacing, 2 inches, must be used. It probably has no ad- vantages over the longer waves in the short-wave field, and is more dangerous because the sensation of skin heat is not marked. Hyperpyrexia (fever) can be easily induced in human subjects with high- frequency currents. This procedure however has definite dangers unless prop- erly supervised, and should only be used in hospitals under direction of a medical officer familiar with this form of treatment. A short-wave or inductothermy apparatus of suitable power, and insulating material are necessary. With short-wave diathermy, several insulating systems are used. The Kettering Hypertherm, an air conditioned cabinet, heated with an electric unit and controlled by easily accessible humidistat and thermostat, is an efficient apparatus. The patient (with weight bearing points greased) wrapped in toweling to absorb perspiration may be placed in a heavily insulated sleeping bag arrange- ment. Large electrodes are then placed over the body and the current applied. They should be moved frequently to avoid uncomfortable heat under them. The cable of the electro-magnetic machines, fixed in a disk and supported by a stand makes for easy application. This is also incorporated into a cabinet, and makes an efficient unit. The patient may also be effectively insulated by wrapping in toweling, a rubber sheet, and blankets. A temperature rise of 4 to 5 degrees F. is usually obtained the first hour, depending on the insulation, and the current is stopped about 1 degree F. short of the desired maximum. The current can be re- applied from time to time to maintain the desired temperature. In the treatment of resistant gonorrhoeal conditions a temperature of 106 to 107 degrees F. is necessary for several hours. A frequently used treatment is a 10-hour period, and one such treatment is often sufficient for cure. The patient may need sedatives as sodium amytal or codeine, cramps or tetany may occur and require 10 cc of sodium gluconate intramuscularly. Tongue forceps, oxygen, and car- bon-dioxide mixtures should be available for use if respiration becomes em- barrassed. Intravenous dextrose, morphine sulfate, epinephrine chloride, and caffeine benzoate should also be prepared. Sodium chloride, 0.3 per cent, is given in water steadily. After the desired temperature is reached cool cloths 936 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY are used on the head. The temperature and pulse is taken every 15 minutes. Oral temperature is unreliable. After the treatment is completed, the patient is carried to bed, heavily wrapped in blankets, and the temperature is taken every % hour until normal. Fluids are continued. Hyperpyrexia is most commonly used in gonorrhoea resistant to other treat merit, nervous-system syphilis, cholera, and other neurological conditions. Precautions with short-wave diathermy.—No metal parts in thfe treatment field (as hairpins). No metal or rubberoid materials on the treatment table. Cable must not touch the patient or chair, or the other cable. Do not treat through clothing, and inspect treatment area after each treatment. Do not use damp towels or felt for spacers. No not use pressure over bony points. Close points must be avoided in spacing. Treat anaesthetic areas with at least 2 inches skin distance. Do not give treatments “by the meter.” Never disregard complaints of too much heat, and check applicators if unwanted point heating is complained of. Do not treat deep closed abscess cavities. Check spacing over protruding areas, as ears, etc. Do not touch electrodes with current on. Do not place electrodes on concrete, marble, or linoleum floors. Keep electrodes within 3 feet of each other. Avoid transcranial application when possible. Electro-surgery denotes the application of electricity for the destruction of new growths and diseased tissue; and for cutting through normal tissue with minimal bleeding. Electro-desiccation.—A needle point electrode connected to a single high voltage (Oudin) terminal is held in contact with or at a slight sparking distance from the area to be treated. It is a high voltage and low amperage current, the oscillations are damped, and result in drying and shrinking of the tissue due to water evaporation. A dry mass results which may be curretted or will slough oft if left alone. Fulguration is the biterminal use of current from a high frequency coil. It is painful and has no advantage over desiccation. Electro-coagulation.—This requires higher amperage and damped oscilla- tions. A large dispersive electrode and a small active coagulative electrode is used. Although it is effective it is hard to regulate the size of the area coagulated. Two small active electrodes as needles may be used and this limits the reaction to a small area between the needles. Electro-section.—A needle point or thin blade is attached to one terminal of a high frequency apparatus current of undamped oscillations. This point cuts tissue readily with a minimum of coagulation, simply sealing the capillaries. References Electrotherapy and Light Therapy.—Kovacs. Physiotherapy.—Stewart. Instruction forms for physiotherapy patients, The Mayo Clinic.—Krusen. Handbook of Physical Therapy.—Council on Physical Therapy, The American Medical Association. Section 11.—RECRUITING The strength of the Navy greatly depends on manpower and manpower is measured by the physical fitness of its personnel. This being so, it may be stated (hat the selection of the recruit is one of the most important functions of the Navy. In order that enlistment may be possible to all, without the necessity of travel- ing long distances from their homes for the purpose of examination, recruiting stations are located in various large cities throughout the United States. RECRUITING 937 Generally the complement of a recruiting station consists of: The officer in charge of the station, usually a line officer who has been in the Navy a number of years; the medical officer, whose duty it is to examine carefully every applicant as to his physical and mental fitness and adaptability for the Navy; one or two yeomen for the regular office work; and a hospital corpsman to assist the medical officer. The hospital corpsman is an integral part of the recruiting activity, and as a member of the medical department his duties are important. Especially is this the case where a pharmacist’s mate is on duty at a substation or outlying station away from a medical officer. Here he must perform in a measure some of the functions of the medical officer in the preliminary examination of applicants and in eliminating those unfit for further examination. That means he must be capable and efficient, courteous and tactful, and well versed in the affairs incident to recruiting. It is well, therefore, to give an idea of the Organization of the Recruiting Service and its workings. The Recruiting Section is a regular part of the Bureau of Navigation, consti- tuted and operated like any other section of that bureau. From it come the orders and instructions governing all recruiting activities. For convenience and efficiency, recruiting in the United States is separated into five divisions as follows: Northeastern; Southeastern; Southern; Central; and Western. Under the above divisions there are about 35 Recruiting Districts and approxi- mately 200 substations. There are two Recruiting Training Schools, one at San Diego, Calif., and the other at Hampton Roads, Ya., where special instruction and training are given to men prior to their assignment to duty at recruiting stations. It has been the policy whenever practicable to send pharmacist’s mates to these schools for the course of instruction when assigned to recruiting duty. Members of the Hospital Corps to be eligible for such duty must be in good health, free of venereal diseases, and dentally sound. The principle duties of the recruiting personnel are to secure suitable applicants and to enlist them in the Navy. A definite selective system is employed in securing applicants. This system aims to procure recruits of the highest quality. Such a method of recruiting raises the Navy standard; it also results in a smaller turnover in the personnel of the ships, in higher efficiency in ship operation, in reduction in desertions and discharges, and reduction in the cost of recruiting. Mistakes in recruiting resulting in rejection at the training station are expensive. It costs the Government about $650.00 to replace one man lost through avoidable means during the first year of enlistment. The advantages which the Navy has to offer the applicant are: 1. A career; 2. Education (opportunity to learn a trade) and travel; 3. Physical improvement; and 4. A steady job with regular pay. In return for these the Navy demands a full enlistment and a standard physical make-up. Here is where the medical department is chiefly concerned, which concern is the selection of applicants who measure up to the Navy standards for enlistment. The chief duties of the medical officer are to review all applicants and give each a thorough and efficient physical examination to determine his physical qualifications. If the applicant cannot meet these requirements he is rejected. 938 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY The hospital corpsman is an assistant to the medical officer, and his duties are; 1. To assist in making contacts; 2. To assist the medical officer in physical examinations; 3. To help detect underlying defects in applicants; 4. To take care of recording and clerical work; and 5. To assist the medical officer in caring for station personnel. The pharmacist’s mate is an important cog in the recruiting machine and must fit in with the organization for its efficient operation. He should be selected with an eye to personality, education, and professional ability. Like the other members of the station he represents the Navy; he must look the part, be properly and neatly uniformed, and in all respects be prepared to uphold the high standards of the Navy in the community in which he is stationed. He must make the right impression upon the civilian population both in and out of the examining room. Responsibility for accepting only those qualified physically for the service rests primarily with the medical personnel. This means a thorough investi- gation of the applicant’s past history and his present status from standpoints of family and environment, together with a thorough physical examination. There are two forms used at recruiting stations that are very useful in evaluating the physical requirements of the applicant. One is N. R. B. Form 10, which is the Recruiting Physical Examination Check-off List for use of nonmedical recruiters solely as a preliminary to the medical officer’s exam- ination. Use of this form enables recruiters to eliminate individuals who would not pass an examination before a medical officer. It does not take the place of the physical examination by the medical officer, and any applicant who is rejected by it may make a final appeal to the medical examiner at the recruiting station. No applicant is accepted or rejected solely on the findings of this check-off list. The other form referred to is N. R. B. Form 24. The first two pages of this form cover the application for enlistment; the third page is a record of the physical examination; and the final page is the applicant’s physical questionnaire. This form gives a complete picture of the applicant as to his origin, home life and education, and physical make- up ; and also a record of disabilities and abnormal conditions he may now have. This physical questionnaire prepared by the recruiting station is forwarded to the training station in cases of all accepted applicants, for further reference. Every care should be used in making out this questionnaire, and it is the hospital corpsman’s duty to see that the questions and answers by the appli- cant are thoroughly understood and the applicant is warned as to the serious- ness of any false statement. Conditions such as bedwetting, fits, painful feet, and many others cannot be discovered unless the applicant is questioned definitely and pointedly on each defect named in the questionnaire. The easy way of just handing the applicant this blank form and allowing him to struggle over it himself defeats the purpose of the form. Proper conduction of the physical investigation and examination will elim- inate the unfit in most cases. It has been found that a large number of defectives were aware of their condition before enlistment. Painstaking and thorough examination of these at the time of interview would have elimi- nated most of them. The hospital corpsman, due to his close contact with the applicants, is in a position to materially aid the medical officer in discovering these underlying conditions. Failure to eliminate the unfit results annually 939 RECRUITING iii discharges by medical survey, and by inaptitude and undesirable discharges. This means unnecessary expense to the Government. During the examination refrain from an over-bearing attitude toward the applicant; a hospital corpsman must remember that the people he comes in contact with on recruiting duty are neither in the naval service nor are they his subordinates. Courtesy will reward his efforts, for the public will be impressed and formulate their opinion of not only the recruiting personnel but of the Navy as a whole by his general appearance and conduct. Especially on recruiting duty one’s private life must be strictly above reproach. Drunkenness, financial irresponsibility, marital troubles, or any scandalous conduct will not only reflect upon the individual but also upon (he Navy as a whole. Many recruiting stations are in inland cities where few people know much about the general activities of the Navy and many questions will be asked, so it becomes an additional duty of a hospital corps- man to be able to intelligently give definite answers to many questions on Navy matters, such as advancement in ratings and pay, and the opportunities available for learning a trade. Some of the more common physical causes of separation from the service are: 1. Bed wetting; 2. Epilepsy; 3. Flat feet; 4. Defective teeth; 5. Defective ears and hearing; 6. Defective vision; 7. Defective physical development; 8. Hernia; 9. Constitutional inferiority; and 10. Deformities. Bed-wetting and epilepsy as well as constitutional inferiority are frequently covered up by the applicants. They are determined by careful investigation of the home and environment, school and social conduct. Final acceptance is made at the main station after physical examination by the medical officer. The pharmacist’s mate should be thoroughly familiar with the sections of the Manual of the Medical Department covering the physical examination of applicants for enlistment and should have at hand a list of causes for rejection. Physical defects should not be overlooked for they will be detected later at the training station and will result in the recruit’s discharge from the service. Such errors reflect on the medical staff making the examina- tion and lower the rating of the station, and incur useless expense to the Government. It is necessary that careful consideration be given to the dental condition of all applicants for enlistment. The hospital corpsman is expected to be able not only to note the loss of a sufficient number of teeth to constitute a disqualifying defect, but also to detect gross pathological conditions of the teeth and theii surrounding structures which would make the applicant for enlistment a poor physical risk. He should endeavor to acquaint the substation personnel with the dental requirements for enlistment and the causes for rejection. Explanation of some of the dental standards or requirements which are often misconstrued follows. 1. An opposed tooth is one that comes into functional contact (hits or strikes) with one or more teeth of the opposite arch (jaw). 2. A vital tooth is a tooth containing a vital (not dead) dental pulp. 3. A serviceable tooth is one free from advanced disease, and that does not have a faulty restoration, crown or bridge attachment. 4. A permanent tooth is a natural tooth of the second dentition. Deciduous (temporary or baby) teeth are not counted as serviceable teeth. 5. An edentulous space is a space (gap) without natural teeth. 6. Malocclusion is a condition of malposition of the teeth resulting in abnor- mal occlusion (teeth do not mesh properly), or in a protrusion or retrusion (over or underbite) of either arch. 154294°—39 60 940 HANDBOOK OF THE HOSPITAL CORPS, XL S. NAVY Hospital corpsmen assigned to duty at recruiting stations should have ade- quate clerical ability in order to take care of recording and clerical work. A hospital corpsman often has to do this work in the main office with the yeomen, and his personality should be trained to fit in with that force. It may be de- sirable or necessary at times for each to assist the other in carrying out the clerical work. To illustrate the clerical work to he performed by a hospital corpsman, the following procedure is necessary for every recruit taken into the Navy: 1. Complete Form N. Nav. 2. 2. Complete pages 3 and 4 of service record. 3. Complete shipping articles, Form N. Nav. 351. 4. Complete application, Form N. R. B. 24 (previously mentioned). 5. Complete health record, N. M. S. Form H. 6. Complete N. M. S. Form “X” (Card). Besides these the routine medical-department reports and returns have to he submitted as indicated. Page 4 of the service record contains fingerprints. Especial care should be exercised in making fingerprints as they are a permanent record and at some future time may be a sole determining factor of identity. Smeared prints are useless and always must be remade. There is another feature in connection with recruiting that comes back to rest with the Hospital Corps. Quite a number of hospital corpsmen are obtained from the ranks of the regular recruits. Recruits at the training sta- tions are made familiar with the Hospital Corps and medical-department activi- ties, and are given an opportunity to transfer to that organization whenever they so desire and are found to have the necessary educational qualifications. Many good men are taken from the ranks of apprentice seamen, sent through the Hospital Corps Schools and become hospital apprentices, second class. Watchfulness to this end will help much to secure recruits of the superior type which the Hospital Corps demands. Section 12.—X-RAY To become a competent X-ray technician requires special training. However, there are many small X-ray units that may be safely operated by carefully following the manufacturer’s instructions provided the operator uses the proper safety precautions. Before attempting to operate even small units, it is a great advantage to know the principles of X-ray production and control. X-ray equipment is expensive and easily damaged, and when it is placed in ignorant hands, the danger to patients and operator can become very great. The in- formation in the following pages will help operators to learn the reasons for the various controls and procedures. Further detailed instructions should be obtained, preferably by demonstrations, before attempting to use equipment. HISTORICAL X-rays were discovered by Whilhelm Konrad Roentgen at the University of Wurzburg, Bavaria, in 1895. Many previous investigators had paved the way for his discovery. The colors produced in a vacuum tube by high voltage electric current had been observed by Geissler. Crookes had studied the effect of gradually increasing the vacuum until no current would pass through the tube. Other experimenters had discovered, during 35 years of research, that X-RAY 941 eertain crystals would give off light (fluoresce) when they were near such tubes in operation. Roentgen, however, made this important change in the usual experimental conditions—he covered the tube with black paper so that no light was visible. A neighboring cardboard, coated with barium platinocyanide crystals, gave off light as usual. But there was no visible light to activate the crystals. Fur- thermore Roentgen was astounded when his hand accidentally came between the tub© and, screen and he saw the dim outlines of the bones. He reasoned that there must be some invisible rays coming through the black paper covering the tube. Roentgen called these unknown rays “X-rays” and they have been known by this name ever since. They are also known as Rcentgen rays. THE NATURE OF X-RAYS X-rays are now considered as wave motions in the ether. The ether is the theoretical substance that fills all space. X-rays are similar in some respects to the rays of light emanating from the sun. There are several important differences: Visible sunlight can be broken up into its different colors (dif- ferent wave lengths) or spectrum by a glass prism. Invisible X-rays, whose wave lengths are about 5,000 times shorter, can be broken up only, as far as is known, by certain crystals. They can neither be reflected from a mirror nor focused through a lens. The most useful property of X-rays is their ability to penetrate solid objects. This they do in nearly direct proportion to the density of the object. Such materials as paper, cardboard, cotton, gauze, and wool are easily penetrated. Metals produce more obstruction. While a Via inch thickness of a light metal such as aluminum can be readily penetrated, the same thickness of lead obstructs all but the short wave lengths. There is a great difference in penetrating power of the short and long wave lengths. The shortest will penetrate over an inch of lead (million volt tube) while the longest will barely penetrate cardboard (Grenz rays). For “seeing through” the human body, best results are obtained when the predominant wave length is just able to penetrate the denser parts. A beam of X-rays coming from a tube is composed of various wave lengths. By means of metal filters such as thin sheets of copper and aluminum the longer wave lengths are stopped (absorbed). The shorter ones go on through but still differ among themselves as to length and penetrating power. The production of the shadow of an object by Roentgen rays (X-rays) depends on: 1. The difference in density of the object and its surroundings; and 2. The penetrating power of the X-ray beam selected. When the difference in density is great and a beam of proper penetrating power is used the contrast of the shadows on the film or screen is good. For example, the shadow of the dense heart will stand out very well because it is surrounded by the air filled lungs. The long bones are easy to demonstrate because they are surrounded by soft tissue of much less density. The organs of the abdomen are seen with difficulty because they and their surrounding structures are all of about the same density. Various methods have been devised to increase the density of certain organs. The stomach and colon are filled with barium mixtures. The kidneys and gall bladder are visualized by injecting certain dyes into the vein of the arm or taking them by mouth. The dyes are concentrated in the organ and increase its density so that it stands out from its surroundings. It is highly important to remember that the object itself is never seen. What is seen is the shadow of the object. Just as hands and fingers may be ar- 942 HANDBOOK OF THE HOSPITAL COUPS, IT. S. NAVY ranged between a light and a white sheet to throw shadows resembling snakes, dogs, ducks, etc., so may the shadows on X-ray films and screens resemble things they are not. PRODUCTION OF X-RAYS To generate X-rays it is necessary that: 1. Electrons be separated from their atoms; and 2. Separated electrons be hurled with terrific velocity (% to Vz the speed of light) against a suitable material. The following is a simple explanation of X-ray production: “If a handful of marbles is thrown against a drum head, the marbles set up vibrations in the drum. These vibrations set up vibrations in the air that are recognized by the ear as sound. The marbles represent the electrons; the force that sets the marbles in motion represents the high voltage electric current that sets the electrons in motion; the drum head corresponds to the target of the X-ray tube; the sound waves produced in the drum correspond to the X-rays pro- duced in the X-ray tube.” The sound waves are long and travel through the air about 362 yards per second, while the X-ray waves are short and travel through the ether with the speed of light or 186,000 miles per second. Electrons and atoms.—In the past atoms were thought of as the smallest parti- cles of matter that could exist, which were joined together to form molecules. Today is it believed that atoms are composed of positive and negative charges of electricity which usually are exactly equal in number. The positive charges (protons) are considered as being contained in a central nucleus with part of the negative charges (electrons), the remaining negative charges revolving around the central nucleus in orbits like the earth revolves around the sun. (See chapter on Chemistry for a fuller discussion.) When an atom has an equal number of protons and electrons it is a balanced atom, but this balance may be disturbed by several methods, a common one being the use of heat. When this occurs one or more electrons revolving in an orbit are lost and the atom is unbalanced. An atom may also become unbalanced by taking up electrons. When an atom loses electrons it has more positive than negative charges and is electrically positive as a whole. If an atom gains elec- trons it has more negative than positive charges and is electrically negative as a whole. If two such unbalanced atoms approach near enough to each other the excess electrons in one leave and take up the vacant places in the other and both atoms are again balanced. When atoms are unbalanced there is a stress or tension between them due to the positive and negative charges seeking each other. This tension is spoken of as difference of potential or voltage. When the negative charges finally move toward the positive the resulting flow of electrons is called an electric current. This flow is always from negative to positive. X-ray tubes.—A common type of X-ray tube, which is rapidly disappearing, is the Coolidge Universal Tube shown in figure 182. The tungsten anode (A) has a high melting point. This is important because about 99 per cent of the energy striking the anode is turned into heat. About 1 per cent is used to produce X-rays. The anode is the positive side of all X-ray tubes. The cathode (C) or negative side of the tube contains a filament of tungsten wire similar to that of a small electric lamp. This is heated to white heat by the current in a small 12-volt circuit. The atoms of the filament are unbalanced by the heat which drives numerous electrons of negative charge to the surface. These negative electrons stay on the surface of the hot filament until high voltage current is applied to the positive and negative terminals of the tube. They are then attracted to the target which is positive. During 943 X-RAY their travel of less than iy2 inches from filament to anode, these electrons attain enormous speed. They strike the target when their velocity is about one-half to one-third the speed of light. This tremendous speed sets the target into vibration causing it to give off wave motions in the ether known as X-rays. Figdre 182.—Coolidge universal tube. A, anode and target; C, cathode containing filament All X-ray tubes are vacuum tubes. Producing a high vacuum is difficult and methods of attaining it are prized by manufacturers. Theoretically a per- fect vacuum without electrons will not pass an electric current no matter how high the voltage. If the number of electrons released by the hot filament can be controlled, the amount of current that will pass through the tube can also be controlled. This, in turn, will control the quantity of X-rays produced. This is actually done by controlling the heat of the filament and is the big advantage of a hot filament X-ray tube. Prior to the perfection of this tube by Coolidge, electrons were badly controlled by adding and removing gas from a tube with a low vacuum. The gas tube is now rarely seen. The radiator type Coolidge tube (figure 183) followed the universal type. The radiator (R), combined with a heavy copper anode (A), carried the heat away from the target much faster. This did away with “inverse” current when Figure 183.—Radiator type tube. A, anode and target; C, cathode containing filament; R. radiator for cooling anode. the tube was used without a rectifier (see figure 192). Then the glass bulb was made smaller and the radiator tube became a favorite for bedside machines and fluoroscopes on account of its small size and simple operation. However, its capacity of 10 to .‘10 milliamperes is too limited for high speed radiography. To overcome these shortcomings, the heavy copper anode has been made heavier and the glass bulb larger. This allows even more rapid loss of heat. By adding a reservoir and circulating water around the anode, very rapid loss of heat has been attained. Tubes with 100 milliampere capacity and higher are now commonplace. 944 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY To obtain fine detail it is necessary to project X-rays from a small area on the target to film or screen. This is done by a focusing shield around the fila- ment (figure 184). When electrons leave the filament, most of them are Figure 184.—Method of focusing electrons on the target. T, target; F, focal spot; S, focusing shield; HP, hot filament; X, X-ray beam. focused on a small spot on the target. Tubes with focal spots less than 3 millimeters in diameter are called fine focus tubes. If the usual 45-degree slope of the target face is made smaller, it becomes possible to focus the cathode stream (or electrons) on a long, narrow line, instead of a small round spot, and the useful part of the X-ray beam is projected as a small square (figure 185). The great advantage of these "line focus” tubes is that the heat is dis- tributed over a larger area on the target. tungsten target filament ACTUAL FOCAL SPOT AREA AREA OF EFFECTIVE FOCUS Figure 185.—Line focus, showing electrons focused on a much larger area than in Figure 184. Hence the metal is not raised to the melting point as quickly. Figure 186 shows a line focus tube that is covered by a metal envelope (M). This is reinforced with lead near the anode. The latter prevents X-rays leaving the tube except through the opening directly under the line focus. The anode end takes either a radiator or a water reservoir. By using two filaments with a selective switch, one tube may serve for both flue and broad focus uses These are called double focus tubes. X-RAY 945 Figure 186.—Protected line focus tube. A, anode terminal; C, cathode terminal; F, fila- ment ; L, lead lining above and below target with X-ray window ; M, metal envelope. Figure 187 shows a rotating anode tube. The disc-shaped anode is rotated by a small motor. Heat is distributed over the whole circumference of the disc. This tube will do the heavy work of a broad focus tube with the tine radiographic detail of a fine focus tube. 15’ ANODE FACE ROTOR BEARING STATOR WINDINGS CATHODE CONNECTIONS ROTOR ANODE CONNECTION TUNGSTEN DISK ANODE X-RAY WINDOW PYREX GLASS Figure 187.—Rotating anode tube. (General Electric X-ray Corporation.) STATOR PUNCHINGS Various types of tubes are used for treatment. Some of these are very large, require upwards of one million volts to operate, and must be installed in specially constructed buildings. The separation of electrons from their atoms and how they are stopped abruptly by the target of the X-ray tube has been explained. The force that hurls these electrons with terrific velocity against the target is the high voltage electric current coming from the secondary coil of the X-ray step-up transformer (figure 188). A modern X-ray transformer consists of a square or ring of iron (closed core) with two separate coils of wire. One coil is called the primary, the other the secondary. They are insulated from each other by the surrounding coil. The secondary coil has many more turns and is made of smaller wire than the primary. Low voltages are sent through the primary coil. This causes the whole iron ring to become a magnet. The magnet induces a high voltage current in the secondary coil. This induced current will have a voltage in direct proportion (ignoring losses) as the number of turns in the primary coil is SECONDARY HIGH VOLTAGE CURRENT 946 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY to the number of turns in the secondary coil. For example, suppose there are 22 turns of wire in the primary coil with a voltage of 220. If there are 8,80b turns of wire in the secondary coil then there are 400 times as many turns as there are in the primary, hence, the voltage in the secondary coil is 400 X 220 — 88,000 volts. Figure 188.—Diagram of X-ray transformer wiring. Induction. The 88,000-volt current just mentioned is an induced current. Electric cur- rent can be created or induced in a coil of wire by pushing a magnet within the coil (figure 189). Also, a magnet can be treated or induced by placing a bar of soft iron in a coil of wire carrying an electric current. Figure 189.—Induction. When a magnet, NS, is pushed into a coil of wire, lines of mag- netic force, LF, are cut, causing an electric current to flow in the wire and register on the galvanometer, G. (After Sante.) In the X-ray transformer the ring of iron is turned into a magnet when electric current is passed through the primary coil. This magnet has a field of magnetic influence surrounding it, which is similar to the field shown in figure 18!). It is convenient to picture this field as “lines of magnetic force.” When lines of magnetic force are being cut by a wire passing through them, an electric current flows in the wire. When the motion stops the current stops. Increasing the number of turns of wire around the magnet increases the num- ber of lines of force that are cut which increases the amount of current pro- duced. If the lines of force can he moved across the wire it amounts to the same thing as moving the wire across the lines of force. These lines are rap- idly nn)ved by the alternating current flowing in the primary coil. If direct current is used, it must be changed to alternating current before it reaches the transformer. This is accomplished by a rotary converter. When speaking of volts the pressure of an electric current is meant: when speaking of amperes the rate of flow is meant, A high pressure can be pro- X-RAY 947 duced in a small water pipe by a pump while the volume of water flowing will be small. A high voltage can be produced in a small sized wire by a step-up transformer, yet the amount of electrical current flowing (amperage) will be small. This is a suitable type of electrical current for the production of X-rays. The voltages used for production of X-rays usually vary from 30,000 to 200,000. These are awkward figures and the custom has developed of measur- ing in “kilovolts”. One kilovolt equals 1,000 volts; 80 kilovolts equals 80,000 volts, etc. These high voltages are measured by observing the distance they will cause a spark to jump through air. The point gaps or sphere gaps are gradually closed by moving the points or spheres toward each other until a spark jumps across. The scale of point gaps reads in inches. Six inches equals about 100 kilovolts. The scale of sphere gaps reads directly in kilovolts. The amperages used for production of X-rays vary from 0.004 to 0.500 of an ampere. These figures are awkward, so amperage is measured in “mili- amperes”. One milliampere equals 0.001 of an ampere; 50 milliamperes equals 0.050 of an ampere, etc. Milliamperes are measured by a special type of ampere meter called a milliammeter, which is connected in the high voltage secondary circuit. On small units a low voltage meter is mounted on the con- trol stand. This meter is calibrated in milliamperes at the factory by compar- ing it with a standard milliammeter. Rectification. When the high voltage current leaves the secondary coil of the transformer it is alternating current. Like the current introduced into the primary coil, it rises from zero to its peak and falls back to zero again (figure 190). Then the VOLTAGE Figure 190.—Wave forms of low voltage primary alternating current and high voltage secondary full wave rectified current. The form of the latter, which is direct pulsating current, has been modified by condensers. current reverses its direction and falls below zero an equal amount to return again to zero. These events are called a cycle. Most electric power supplied to- day is 60 cycle alternating current. That means that 60 such cycles occur every second or 8,600 cycles occur every minute. Each cycle has two impulses which flow in opposite directions. To produce X-rays it is necessary that current flow through the X-ray tube in one direction only. It must flow to the cathode where it is picked up by “small boats” (electrons) and carried to the anode. The current must always leave the anode and return to the transformer in order to complete the circuit. One way of doing this is to select only that part of the alternating current that is flowing in the right direction. In other words, only half of each cycle is used. This is called half-wave rectification. If the target of an X-ray tube 948 HANDBOOK OF THE HOSPITAL CORPS, IT. S. NAVY can he kept cool enough so that electrons will not be released from it, the tube itself will make this selection (self-rectification). With electrons available only at the hot filament (cathode) the current must approach from the cathode side to find transportation. When the current tries to cross from anode to cathode, no electrons are available. This is satisfactory for a small number of watts (volts X amperes = watts), hut when more watts are used the target heats, electrons are released and “in- verse” current passes from anode to cathode. Hence, when more X-rays or more penetrating X,-rays are wanted, it becomes necessary to rectify the cur- rent before it reaches the X-ray tube. Many ingenious methods of rectification have been devised. Figure 191 shows a mechanical rectifying switch in the shape of a disc. The disc is made of insulating material that carries copper contacts. It is turned by a syn- chronous motor that makes one-half of a complete revolution on each cycle Figukb 191.—Diagram of rectifying disc in two positions, of the alternating current. As there are 30 revolutions of the disc per sec- ond and 60 cycles of alternating current per second, the disc can he adjusted on the shaft so that the contacts reach the terminals connected to the trans- former at just the right moment. Thus, the current entering the switch is chang- ing its direction 120 times per second while the current leaving the switch has 120 impulses per second but all in the same direction. Figure 192 is a valve-tube rectifier. Modern valve tubes have a cylindrical metal plate (A. A.) surrounding a spiral filament. The filament is heated by a current of 12 to 14 amperes passing through the terminals (F. F.). The hot filament releases electrons which carry the current across the vacuum to the plate. This tube will pass current only in the direction of the large ai’row. Figure 192.—Valve tube. A. A., cylindrical metal plate surrounding a spiral filament; F. F., filament terminals. (Sante.) Figure 193 is a two-valve, half-wave rectifier. When the current from the X-ray transformer is flowing to the left it meets the heated filament of valve tube (A) where plenty of electrons are waiting to carry it across the vacuum to the plate. The current crosses the X-ray tube and valve tube (B) in similar fashion and completes the circuit by arriving at the opposite end of the trans- X-RAY former secondary. When the current is Rowing to the right, it meets the plate of valve tube (B). No electrons are waiting to carry it across and hence no current passes. Notice that only half of each alternating cycle is used and that the X-ray tube receives 60 impulses per second. Figure 193.—Circuit diagram of two-valve half-wave rectifier. Figure 194 is a four-valve full-wave rectifier. When the current from the X-ray transformer is flowing upward it passes through valve tube (A), to X-ray tube, to valve tube (B) and completes the circuit by arriving at the lower end of the transformer secondary. When the current is flowing downward it passes through valve tube (C) to X-ray tube to valve tube (D) and completes Figure 194.—Circuit diagram of four-valve full-wave rectifier the circuit by arriving at the upper end of the transformer. With 60-cyclr alternating current the X-ray tube passes 120 impulses per second. Each valve tube passes 60 impulses and stops 60 impulses per second. Notice that the whole alternating cycle is used. The direct pulsating curve shown in figure 190 is similar to full-wave rectified current combined with condensers. Full- wave rectification wears out the X-ray tube faster than other types because there are no cooling intervals. However, it is very efficient for fast exposures. HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY Figure 195 shows the essential parts of the secondary circuit connected to- gether. The rectifier is a revolving disc type. Other types of rectifiers can be substituted. Figure 195.—Diagram of the principal parts of the high voltage secondary circuit and lilament circuit connected to X-ray tube. Sec., secondary coil of X-ray transformer; R, rectifier; MA, milliampere meter; C, step-down transformer of filament circuit. Before the current enters the primary coil of the step-up transformer, it must pass through several devices. Some of these serve to control the input. Others serve to automatically shut off the current in case of grounding or short circuit. PRIMARY LOW VOLTAGE CURRENT Fuses. If one starts at the power panel switch or lamp socket to which the X-ray machine is connected, the first devices usually met are the fuses. These are similar to the fuses of a lighting circuit in a private home. A small bedside machine will be equipped with 10- or 15-ampere fuses. A large X-ray machine may carry 200-ampere fuses or larger. Such fuses consist of a short piece of flat wire inside a cartridge with contacts on each end, or they may be the type that screw into a socket. A fuse wire de- signed to pass 200 amperes of current at 220 volts should melt if more than 200 amperes is “drawn” by the X-ray machine. Most X-ray machines never \ise this amount of current unless something goes wrong. This something is usually a “grounded” circuit and may be on either the primary or secondary side. Because the secondary circuit is high tension, which is constantly seeking escape, most “grounds” occur there. This makes it easy for current to flow because the re- sistance of the X-ray tube has been avoided. The situation is similar to a bursted water main. Great quantities of current are demanded from the trans- former. The voltage (pressure) drops and the rate of flow (amperes) increases. Unless something is done immediately, the heat generated by the heavy current will “burn out” the transformer, or, worse still, if a patient’s or operator’s body is responsible for the ground, this heavy current is passing through him and may result in death. While fuses can usually be depended upon to protect the transformer from “grounds”, they are not always dependable for protection of personnel. A per- son may “ground” the high-tension current sufficiently to kill himself and yet not make good enough ground contact to pass a heavy current that will melt the fuses. The best method is to use fuses whose capacity is just above the routine operating requirements of the X-ray machine. X-RAY 951 On leaving the fuses, the current usually meets another safety device called a circuit breaker. A simple type (figure 196) is composed of a coil of wire surrounding a bar of iron (I). The coil is connected in the primary circuit. OPEN CLOSED Figure 196.—Diagram of circuit breaker. When the primary current increases beyond the limit set, the iron bar, I, is drawn farther into the coil of wire and strikes the liber plunger, F, which trips the spring device, S; (’, contact; SC, incoming special circuit; MS, outgoing circuit to magnetic switch ; P, handle for setting breaker ; SS, set screw. Whenever an unusual amount of current starts to flow, the iron bar is drawn, by magnetic force, farther into the coil. Here the bar meets a plunger (F) which trips a spring device (S). This opens the contact (0) and the primary circuit is broken by a magnetic switch. The circuit breaker may be made more sensitive by pushing the iron bar farther into the coil by means of the set screw (SS). After the primary current has passed through the fuses, circuit breaker, and a line switch, it meets the autotransformer (AT in figure 197). This is a de- vice which steps down the voltage by induction. It consists of a single coil of heavy wire wound around an iron bar (B). The same coil of wire serves as both primary and secondary. It is a proven fact that two electrical currents may travel over the same wire without interfering with each other. Telephone wires often carry several dif- ferent circuits at the same time. When alternating current flows through the coil of the autotransformer it produces lines of force about the iron bar. These 952 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY lines of force are cut by the same coil of wire that produced them. If the taps from the coil are removed a current of the same voltage as the primary will he induced in the same coil. This induced current always works against the pri mary current. As the voltage of the primary alternating current is falling the voltage of the induced current is rising. The net result is zero as far as flow (amperage) of current is concerned. Such a device is known as a choke coil. The Induced voltage is called counter electromotive force. Figure 197.—Diagram of the principal control devices in the primary circuit. A, incoming alternating current; AT, autotransformer with iron bar, B, and contact arm, C; RH, rheostat with resistance coils, D, and contact arm, E; F, X-ray switch; T, outgoing alternating current to X-ray transformer. Adding the taps or leads to several coils, and connecting any two of them to a current consuming circuit, makes an autotransformer out of a choke coil. The induced voltage now has an outlet. Not all of it is expended in “bucking” the primary voltage. This also allows primary current (amperage) to flow because there is less force against it. In practice, both the primary and induced low voltages are referred to as the primary circuit of the X-ray transformer. When the contract arm (C) is on the button as shown in figure 197, there are 15 turns of wire in the outgoing circuit. As there are 85 turns in the whole coil the incoming voltage is to the outgoing voltage as 35 is to 15. In other words, the outgoing voltage is three-sevenths of the incoming. Thus, if the incoming voltage is 110, the outgoing voltage, ignoring losses, will be % of 110 or 47 volts. Modern autotransformers have many more turns of wire and many more taps so that steps of 2 volts may be obtained. It is bad practice to change the setting of an autotransformer when it is passing current because of arcing between contact points. The reading of the voltmeter is controlled by the autotransformer. Thus the proper incoming voltage for the work in hand may he selected. The voltmeter is sometimes calibrated in kilovolts at the factory where spark gap readings are taken simultaneously with voltmeter readings. The line voltage must agree with the factory voltage for the scale to read correctly. This is adjusted by a compensator which is a small autotransformer and voltmeter connected ahead of the autotransformer. When a compensator is used, the main autotransformer steps may be calibrated in kilovolts and the second voltmeter omitted. On leaving the voltmeter, the primary current usually meets a resistance. In some controls this resistance is permanent and the operator frequently is un- aware of its presence. In controls for larger machines, this resistance is variable and is known as a rheostat (RH in figure 197). A resistance is a coil of wire or X-RAY 953 series of grids that checks the flow of electricity because the arrangement of their atoms is unfavorable. The metal used in rheostats has a high resistance and is a poor conductor. The unit of resistance is called the ohm. A resistance of one ohm will pass one ampere of current at a pressure of one volt. A resistance of 5 ohms will pass 1 ampere of current at a pressure of 5 volts, 2 amperes at 10 ,volts, and 20 amperes at 100 volts. The current used up by the resistance is converted into heat. This is accompanied by a drop in voltage. The rheostat in figure 197 has five coils and a contact button for each coil. Suppose that each coil has a resistance of one ohm. If the contact arm is placed on the button to the extreme left, all five coils are in the circuit. AVith the auto- transformer set to feed 47 volts to the rheostat, the largest amount of current that will pass is a little over 9 amperes. If the voltage should drop to 40 the largest amount of current that will pass is 8 amperes. If the resistance of the X-ray tube is avoided by the current taking an easier path (short circuit or ground), these examples do not hold because the total resistance of the combined primary and secondary circuits has been reduced. Compare the autotransformer to the rheostat. When the supply line voltage entering the autotransformer drops from 110 to 100, the voltage leaving the auto- transformer drops from 47 (when set for this voltage) to about 43 volts. How- ever, the amperage does not drop. Thus, the important difference between auto- transformer and rheostat control is the loss of voltage and current with the latter. When the two methods of control are combined as in figure 197, the rheostat is “cut out” for film exposures (radiography). When giving treatments (therapy) some variable resistance is usually left in so that settings may be changed to compensate for line fluctuations. Figure 198.—Operating devices on control stand. 1, line switch ; 2, X-ray switch ; 3, voltage compensator; 4, voltmeter; 5, autotransformer control; (1, resistance; 7, fila- ment regulator. (General Electric X-ray Corporation design.) X-ray switch,—When the current leaves the resistance it has passed through the various controls and safety devices of the primary circuit and is ready for the primary coil of the X-ray transformer. It is convenient to have a switch at this point that may be opened and closed for short or long intervals (F in figure 197). The time of the X-ray exposure on a film or fluoroscopic screen and the 954 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY treatment of a patient is controlled by closing this switch for the proper inter- val. The X-ray switch is placed on the control stand (figure 198). Frequently there is a timing device and a foot switch connected with it. The latter are merely convenient forms of X-ray switches, all of which send the current to the primary coil of the X-ray step-up transformer. ARRANGEMENT OF X-RAY EQUIPMENT The foregoing discussion started with the production of X-rays and worked backward in the high voltage secondary circuit to the secondary coil of the step-up transformer. Then it started again at the supply line of the ship or build- ing and worked forward in the low voltage primary circuit tc the primary coil of the step-up transformer (figure 188). These two divisions, high voltage and low voltage are arranged in a very different manner. Practically all of the low voltage control and safety devices of the primary circuit are found in the control stand (figure 198). This includes fuses, circuit breaker, line switch, autotransformer, voltmeter, rheostat, and the X-ray switch with its accessory-timer and foot switch connections. The control stand also carries an ammeter and a choke coil or resistance control to regulate the amount of current flowing to the step-down transformer of the filament circuit. The meter may be connected in the overhead system. These regulate the heat of the filament in the X-ray tube. It will be recalled that the heat of the filament regulates the amount of current (milliamperes) that pass across the X-ray tube. This, in turn, regulates the amount of current drawn from the step-up transformer and power line. The low voltage current leaves the control stand at a pressure of 40 to 210 volts and enters the step-up transformer. It leaves the step-up transformer at a pressure of 30 to 200 kilovolts or higher. A pressure of 100 kilovolts will cause a spark to jump across a 6-inch air gap. If this current is not kept confined to its proper channels it becomes very dangerous. This is accompanied by locating the high voltage lines high enough to be out of reach. The connecting wires brought down from the overhead system to the X-ray tube are wound on reels containing a spring. The reels exert a constant pidl and keep the wires away from the table and patient. These precautions have never been “fool proof” and many fatal contacts with high-tension wires are on record. SHOCK PROOF EQUIPMENT Two recent designs of X-ray apparatus have practically eliminated the danger of electric shock. The safest design is that shown in figure 199. All of the high- tension secondary circuit, including the step-up transformer and X-ray tube is mounted on insulators and enclosed in a grounded metal casting. This hollow metal casting or “head” is filled with oil having a high resistance. Starting with small self-rectifying dental X-ray tubes, this design has been developed at present writing to enclose valve tubes, filament transformer, therapy tube, and step-up transformer of 400 kilovolt capacity. Another design encloses only the X-ray tube in oil. This is combined with heavily insulated cables connecting the tube to the overhead system (figure 200). Thus, the most dangerous high tension parts are protected. X-RAY EXAMINATIONS There are two methods of examining with X-ray equipment, the screen and the film. Screen examinations should always be made by persons having exten- sive knowledge of anatomy, physiology, and pathology, Otherwise, they lose X-RAY 955 most of their value and may lead to wrong conclusions. The film method requires similar knowledge for interpretation of the shadows. It will be recalled that these shadows often resemble things they are not. However, the exposure of the film and its processing in the dark room do not require medical training for satisfactory results. This technical part of Roentgenology, as the science of X-ray is called, is rightfully placed in the hands of X-ray technicians under medical direction. Figure 199.—Shock proof tube head. A, step-up transformer ; B, filament transformer ; C, X-ray tube ; D, bakelite X-ray window. (General Electric X-ray Corporation design.) LEAD IMPBECilSATeo COLLARS Figure 200.—Shock proof Coolldge tube unit—oil immersed. (General Electric X-ray Corporation.) Film exposures. Space prohibits a detailed description of the technique of film exposures. Many fine books have been written on this subject, at least one of which should be carefully studied. There are certain fundamental principles that must be followed if satisfactory films are to result: 1. The part should be as near the film as possible, otherwise, the shadow of the part will be much larger than the part itself. 154294°—39 61 956 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY 2. The X-rays passing through the center of the part should usually strike the film at a right angle, otherwise the shadow will be distorted and difficult to interpret. 3. Standard positions as illustrated in technique should he strictly observed. 4. Standard target film distances should he used unless the X-ray equipment is too small for the necessary exposure. Chest films, for example, are usually made at a six or seven foot target film distance. A small bedside unit does not have the milliampere capacity to make such a chest film with a short exposure time. Hence, the distance is reduced to three feet. The amount of exposure necessary varies inversely as the square of the distance (inverse square law). The square of 6 feet is 36. The square of 3 feet is 9. By reduc- ing the distance to 3 feet the amount of exposure necessary is as 36 is to 9. In other words, only one-fourth the number of milliampere seconds used at 6 feet is necessary at 3 feet. Variations in distance and voltage affect the film accord- ing to their squares. Variations in milliamperes and time have far less effect. 5. Motion must be eliminated by using compression bands, sand bags, head holders, etc., and by making sure that the patient holds his breath during the exposure. These important points are illustrated in technique books but usually are not emphasized. Motion frequently ruins a film completely for diagnostic purposes. Scattering. Scattering should be reduced by using cones, Bucky diaphragms and Lysholm grids. Figure 201 shows the principle of the Bucky diaphragm. When X-rays strike a patient’s body many of them are broken up into stray X-rays (S) of longer wave lengths. The effect is similar to light passing through muddy water. These stray or scattered rays take different directions. Many of them strike the film and fog the image. Only the rays coming from the focal spot of the tube and passing straight through the body are wanted. Scattering increases with increased volt- age, thickness of part, and size of area exposed. If the X-rays after leaving the body must pass through small slits between lead strips (L) and these strips are placed close together, very few rays outside of those coming from the direc- tion of the target will get through. The scattered rays strike lead and are absorbed. The lead strips are kept moving during the exposure and thus do not show on the film. A Lysholm grid is made of very thin stationary lead strips placed closely together on a flat base. The shadows of the thin lead strips are not apparent on the film without close inspection. This grid is frequently placed behind fluoroscopic screens to overcome the blurring effect of scattered rays. The simplest and cheapest way to overcome scattering is to use the metal cones that are supplied with most tube stands. The smallest cone is used that Figure 201.—Diagram of Bucky dia- phragm. C, cassette; L, lead strips ar- ranged radially to form a curved grid; S, scattered rays. X-RAY 957 will include the desired area of the body. Scattering is reduced because the X-rays are confined to a narrow field. This method is not efficient for large films but serves very well for the 8 by 10 size. Potter-Bucky diaphragm. In radiography of the thicker parts of the body, such as the spine, pelvis, kidney, gall-bladder, head, etc., increased penetration and time are necessary. The passage of the X-rays through these heavier parts materially increases sec- ondary radiation. This secondary radiation, emanating in all directions from the point of origin, causes fogging, which renders the finer details unrecognizable in the film. Hence, in order to obtain radiographs of proper diagnostic quality, the elimination of as much of the unwanted radiation as possible must be accomplished. This is done by absorption of all except those rays that pass vertically or nearly vertically through the area examined. To accomplish this absorption the Potter-Bucky diaphragm is used. The diaphragm consists of a metal frame holding a “grid” composed of thin, narrow strips of lead, separated by strips of wood. This grid is incorporated in a mechanism so arranged that it can be made to move at a steady, even pace across the plane between the film and the part examined. The speed with which the diaphragm moves can be controlled by the operator and should be regulated to correspond to the exposure time. The distance between the grid and part, as well as the distance between the grid and film, should be as slight as possible. The absorption of secondary radiation necessitates a considerable increase in exposure time. This increase in time depends upon several factors in the con- struction of the grid, chief of which are the ratio between the widths of the lead and the wooden strips, and the depth of the grid. The increase in exposure time with the use of diaphragms ranges from 3 to 5 times that of exposure time without a diaphragm. Bucky diaphragms are usually rated as “High-Speed,” “Semi-Speed” or “Standard.” “High-Speed” diaphragms are for use when very rapid work is desirable; they operate effectively with exposure times ranging from 1/20 of a second to 10 seconds. “Semi-Speed” diaphragms operate with an exposure time ranging from 1/10 of a second to 12 seconds. “Standard” diaphragms operate efficiently with exposure times ranging from % to 20 or more seconds. Fluoroscopy. The fact that certain crystals glow when excited by X-rays was what led to the discovery of the Roentgen ray. When these crystals are finely divided and spread upon a suitable base, a fluoroscopic screen results. The original screen was composed of barium platino-cyanide crystals. After experimentation with thousands of crystals, in 1896 Thomas A. Edison discovered that calcium tung- state made ideal crystals for this purpose. Since then, cadmium tungstate and zinc sulfide have been found to serve best for fluoroscopic screens. The latter,, however, are very sensitive to the actinic rays of sunlight and lose some of their fluorescing ability if exposed to direct light. Consequently, it is necessary to keep such screens covered with dark cloth when they are not actually in use. Roentgenoscopy is the study of bodies by use of X-rays and a fluoroscopic screen. When a patient or object is placed between the screen and the X-ray tube and the tube is activated, shadows, corresponding to the different densities of the part examined, can be outlined on the screen. As the difference in gradu- ation of the shadows is very slight, absolute darkness is essential for careful examinations. For this same reason the eyes of the examining Roentgenologist must be accommodated to the darkness. This accommodation requires a period 958 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY of several minutes in total darkness or may be accomplished by wearing dark or colored glasses. Glasses for this purpose have been manufactured and are in common use, having dark green or red lenses. Fluoroscopy may be done in the operating room or at the bedside with hand or head fluoroscopes in conjunction with a portable or bedside X-ray unit. This tluoroscope consists of a small screen fitted into a light-proof cone. The latter is held before the eyes, either by means of a handle, or strapped to the head, according to the type used. During fluoroscopy great care should be exercised that the patient or operator does not come in contact with the high-tension conductors. It should be borne in mind that great damage can be done by too long exposure to X-rays and that for this reason the examination should be as brief as practicable. The screen should contain a lead glass protective sheet between it and the operator, who should also wear heavy leaded rubber gloves and apron. Radiography. In fluoroscopy the shadows of the image examined are seen upon a screen. In radiography, the shadows are made a permanent record by means of photo- graphic films. Modern X-ray films consist of a special emulsion, containing a silver halide compound, coated in layers about %ooo of an inch in thickness on both sides of a cellulose acetate support or base. This transparent base is about %ooo of an inch in thickness, is slow burning, and presents somewhat less of a fire haz- ard than common newsprint paper. The base is usually slightly tinted with a blue pigment which aids in determining contrast in interpretation of the radio- graph. Such a film is known as “dupli-tized, safety film with a tinted base.” When a film is exposed to X-rays a change takes place in the silver halide salts. The salts that have been affected by exposure are converted into another silver compound through the action of a chemical solution called developer. The unaffected salts are then removed by another chemical solution called the fixing solution. The emulsion of the X-ray film is affected by X-rays, radium, light, heat, moisture, chemical fumes, gases, static electrical discharges, scratching, abrasion, and contact with the fingers. Since any one of these things may cause defects to appear in the radiograph, it is evident that the greatest possible care must be exercised in their handling and storage. Processing procedure.—As X-ray films are extremely sensitive to white light, the processing to bring out and make permanent the radiographic image must be done in a “darkroom.” Such a room may be illuminated by subdued green or ruby light, for it has been found that these lights do not affect the photo- graphic emulsion of the film unless the latter is exposed to them for a consider- able period. Naturally, as in all chemical procedures, processing should be car- ried out with scrupulous care as to cleanliness and ventilation. After the film has been exposed it is quickly immersed in the developing solu- tion. This solution contains the correct proportions of oxidizing agents which convert the affected silver salts into a form of metallic silver. As oxidization takes place only in a neutral or alkaline solution, the developer is strongly alkaline. Development commences in the instant of submersion and continues until all the affected salts have been changed. The time of completion of this chemical reaction depends upon the temperature of the solution. It has been found that immersion of a film in a developing solution with a temperature of 65° F. for a period of 5 minutes will fully develop the recorded image. By decreasing X-RAY 959 or increasing the developing time approximately 20 seconds for each degree of change in temperature, normal development may be accomplished in tempera- tures ranging between 60° F. and 70° F. Belowr the former or above the latter temperature, development should never be attempted unless in specially pre- pared solutions. Powders compounded in the proper proportions are issued to all naval activi- ties having X-ray facilities. The developing solution should be prepared as outlined in the instructions appearing on each container. Distilled water should be used if practicable. There are several cautions that must be observed in mixing processing solu- tions. The vessels or pails should be made of glass or enamelware, for metals, such as galvanized iron, tin, copper, zinc, etc., will cause contamination, and re- sult in fog in the radiograph. After development, the film should be rinsed for about 30 seconds in clean, running water to remove as much of the developing solution as possible. If the film is transferred directly to the fixing bath from the developer, the alkali from the former solution retained on the film will neutralize some of the acid in the fixing solution. After a certain quantity of acid has been neutralized, the bath has lost its chemical balance; the hardening action is destroyed and stains are apt to appear on the radiograph. The purpose of fixation is to remove all unexposed silver salts from the emulsion and to fix permanently the image that has been brought out by the developer. The fixing bath contains not only the fixing chemicals but also those chemicals that harden the gelatin of the emulsion, and it permits ordinary handling and filing of the film without damage. The fixing solution ordinarily used in the naval service is prepared as follows; Acid Fixing Bath Sodium hyposulfite (“hypo”) 2 lb. 8 oz. Acetic acid (28% pure) 5.2 oz. Sodium sulfite 1.6 oz. Potassium alum 1.6 oz. Water to make 1 gal. {To make 28% acetic acid from glacial acetic acid, take 3 parts of glacial acetic acid and add 8 parts of water.) To prepare the bath, dissolve the “hypo” in 48 ounces of water. The water used in dissolving the different ingredients should be at approximately 125° F. Dissolve the sodium sulfite in 32 ounces of water and when it is thoroughly dissolved, add the acid. Dissolve the alum in 32 ounces of water and mix with the sulfite-acid solution. Never add the alum before the acid, or a milky pre- cipitate will result. Now mix the two solutions and add sufficient cold water to make 1 gallon, and stir. The solution must be free from debris and clear. If a milky precipitate results, known as sulfurization, an error has been made in the preparation and the solution should be discarded. Proper fixation has occurred when the film is left submerged in the fixing solution twice as long as is required to remove all trace of the opalescent silver salts. This usually requires from 15 to 30 minutes, depending upon the strength and condition of the solution. After fixation, the film should be washed in running water which is so circu- lating that all parts of the film and hanger receive frequent changes. If the hourly flow in the tank is 4 times the tank capacity, 30 minutes’ wash will be 960 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY sufficient • if the hourly flow is 8 times the tank capacity, 15 minutes will usually be enough. If the flow of water is very slow, 45 or more minutes’ washing will be required. To process films properly, it is important that the temperature of the solu- tions and wash water be the same. The temperature of 65° F. has been selected as ideal. The processing solutions after preparation should be allowed to stand for at least 24 hours to blend before they are put into routine use. They should be kept covered, when not in use, to prevent oxidation. When the level of the solutions has been lowered so that the film is not completely covered, fresh solution should be added. When preparing the solutions, it is a good plan to prepare an extra amount of each, putting the excess in tightly stoppered, amber- colored bottles, to use as the level of the solutions in the tanks is lowered. The practice of adding chemicals to weakened or worn-out solutions should be discouraged. When the solutions become weak they should be thrown out and new ones prepared, for the use of worn-out solutions destroys the quality of the radiograph. New solutions should in any case be prepared at least every 4 to 6 weeks even if the number of films processed is not sufficient to cause exhaustion. Each gallon of developer should properly reduce approxi- mately 5,200 square inches of dupli-tized film surface. Each gallon of fixing solution should fix and harden approximately 2,600 square inches of film sur- face, if films are properly rinsed before immersion. After the film has been thoroughly washed, it should be dried. Most activi- ties are equipped with “dryers”, consisting of a cabinet with electric heating units and an electric fan. The air from the outside is drawn or forced in at one end of the cabinet, passes across the films and out through a duct at the other end. The efficiency of a dryer is about 24 films per hour. Where no dryers are available, radiographs may be dried by hanging in the open air or before an electric fan. It must be remembered, however, that the wet film will pick up particles of dust, so it is important that they be dried in a dust-free room. Darkroom.—The darkroom should be large enough to care for the expectant work. It should be well ventilated, yet as nearly lightproof as possible. It must be kept scrupulously clean at all times and should be so arranged as to facilitate the handling of films, solutions, etc. Such a room should contain the following items: Safe-lights for illumination; a master processing tank with at least two solution tanks and a wash compart- ment, connected to hot and cold running water regulated by a thermostatic mixing valve; a sink for mixing solutions; a film-loading bench into which is built a lightproof film-bin for storage of a small quantity of unexposed films; shelves and compartments for cassettes, film holders, chemicals, etc.; a film- drying cabinet; a lead-lined transfer cabinet; racks for storage of film hangers; towel rack; interval timer, and photographic thermometer. Stkrfjoradiogkaphs.—The principle of binocular vision is that, when objects are viewed with a normal pair of eyes, they appear in their true perspective; that is, they give a sense of depth. This results from the fact that each eye receives a slightly different view of the object and the two images are com- bined by the brain to give the plastic or stereoscopic impression. A single radiograph does not possess perspective and is accordingly called “flat”. It cannot indicate the position of the various parts of the object along the direction of vision. Hence, to overcome this deficiency in the ordinary radiograph, stereoscopic films are made. These are obtained by successively exposing two films, with the object, or part radiographed, and also the film. X-RAY 961 in exactly the same position each time, but with a different position of the tube for each exposure. When these two films are viewed in a stereoscope, each eye sees one film only; but then, as in ordinary vision, the brain fuses the two images into one, showing the various parts standing out clearly in their true perspective. The stereoscope consists of two viewung boxes with two mirrors exactly half way between them at a distance of 25 to 28 inches. The mirrors are so placed that the viewing box on the right can be seen only by the right mirror and the one on the left only by the left mirror. As the average distance between the pupils of the eyes is 2.5 inches, it ap- proximates i,lo of the distance between each viewing box and its mirror. Con- sequently, when the tube is shifted Vio of the distance between the tube target and film, correct fusion of the images will be seen in the stereoscope. Stereo- scopic radiographs should never be made at a distance of less than 25 inches. In viewing stereoscopic films, the examiner should be in the same relative position as that of the target of the X-ray tube when the radiographs were made. Hence, the film taken with a right hand shift of the tube should be placed in the right-hand box and that taken with the left-hand shift in the left- hand box. Then, if viewed from this position, the object will appear to have solidity and relief. Intensifying screens.—Certain chemicals become luminous when exposed to X-rays or other forms of radiation. This property is called fluorescence. Under the influence of X-rays, intensifying screens radiate the light thus produced to the X-ray film, held in close contact between them. The resultant density of the processed film is, therefore, due on the one hand to the quality and in- tensity of the X-rays, and on the other to the type of screen used. The chemicals used in the manufacture of intensifying screens are crystals of calcium tungstate or of zinc sulfide. These finely divided crystals are spread over the surface of a thin sheet of cardboard and held together by means of a suitable binding material. The size of each crystal and the thickness of the coating determine the intensifying factor or speed of the screen. The active surface is glazed as a protective measure. The intensifying action or speed of the screens lessens the time of radio- graphic exposure. The requirements in these screens should include the following points: 1. Screens of the same type should have uniform speeds. 2. They should produce no grainy effect in the radiograph due to large crystals. 3. They should be comparatively free from afterglow. 4. They should have a hard protective surface. 5. They should cause practically no loss in radiographic detail. Screens produced by different manufacturers have varied intensifying fac- tors. Classified according to speed, there are three general types of calcium tungstate screens: 1. Detail or definition (slow); 2. Mid-speed or par-speed (medium) ; and 3. Extra-speed or ultra-speed (fast). These types, obtained from three different manufacturers, were tested at the U. S. Naval Medical Supply Depot, Brooklyn, N. Y. All reached their maximum intensity at a potential of 65 kv. peak with comparatively no loss at higher potentials. The intensifying action of the “fast” type was only slightly greater than that of the “medium” type, but there was a greater loss in radiographic detail in the former. This would appear to indicate that there is no justification for the use of calcium tungstate screens of the “fast” type. 962 HANDBOOK OF THE HOSPITAL, CORPS, U. S. NAVY The zinc sulfide screen gives its maximum intensity at potentials below 70 kv. peak and is not recommended for use above that potential. It is of much higher speed than the calcium tungstate screen at low potentials and so is of great value for the radiographic unit of lower capacity. However, the zinc sulfide screen is extremely sensitive to secondary radiation emanating from heavy portions of the body which require greater kilovoltages for the pene- tration. Hence, if 70 kv. peak is exceeded, a Potter-Bucky disphragm should be used to absorb much of this secondary radiation. Because zinc sulfide screens are very susceptible to the actinic rays of the sun, they should never be exposed to direct sunlight. The use of double intensifying screens decreases the necessary exposure time to about %o of that used without screens. For example: Radiographs requir- ing a technique of 70 kv. peak, 10 ma., 25 inch film-target distance and 5 seconds’ exposure time, without screens, will be duplicated, with the use of double in- tensifying screens, in approximately % of a second. cake of screens.—Intensifying screens, being very delicate and sensitive, should be handled with extreme care. Any particle of dirt or dust, any stain or scratch, will destroy their efficiency. Naturally, they gradually lose their fluorescing ability, but, with careful and conscientious use, screens should last for a period of approximately 18 months. Rules for care of screens.—1. Active screen surfaces should not be touched by the fingers; 2. Chemicals, especially developer, will cause staining of the screen and impair its efficiency; 3. Cassettes should be brushed with a camel’s hair brush at regular intervals to remove dust or small pieces of lint and paper due to insertion and removal of films; 4. Screens may be washed, when neces- sary, with a tuft of cotton, using warm water and a small amount of a pure soap. They should be rinsed immediately and dried before using. Since fre- quent washing impairs screen efficiency, it should be done only when absolutely necessary; and 5. Screens should be properly mounted in cassettes and good contact between screen and film maintained at all times to insure sharp detail in the radiograph. X-RAY TREATMENT The application of Roentgen rays to the human body for treatment (thera- peutic) purposes should not be attempted without the supervision of a medical graduate with special training and experience. Dangerous injuries to patients and technicians in recent years have usually occurred only when this rule has been broken. Roentgen therapy is divided into deep high voltage therapy and superficial low voltage therapy. The dosage is measured in Roentgen units by special instruments. Modern deep therapy uses voltages of 200 kilovolts and higher. The longer wave lengths are absorbed by placing copper, tin, and aluminum filters between the tube and the patient. The resulting X-ray beam is composed of the shorter wave lengths which penetrate to the deeper tissues and have less effect on the skin. Superficial therapy uses voltages between 75 and 100 kilovolts with little if any filtration. Certain skin diseases respond well to the longer wave lengths produced by voltages around 10 kilovolts (Grenz rays). In superficial therapy most of the radiation is absorbed before it passes through the various layers of the skin. PROTECTION The safe operation of X-ray tubes demands that precautions be taken to avoid excessive radiation striking the patient or technician and to avoid contact with the high-tension electrical current. X-RAY 963 Radiation precautions. Serious changes in the skin occur when certain limits of radiation are exceeded. Patients have become permanently bald from too much X-ray exposure to the scalp. A safe working rule for radiography is to always use at least 25 inches target film distance and to always use an aluminum filter, one millimeter thick, in the tube holder. This filter absorbs long wave lengths that affect the skin but fail to penetrate through to the film. Under these conditions 1,200 milliampere seconds to any one part of the body should not be exceeded. When the limit is reached it takes about 30 days for the skin or scalp to recover so that it will take additional radiation without injury. This is true for voltages up to 85 kilovolts which is seldom exceeded in radiography. A bedside machine is frequently used at a 15 milliampere setting. When the exposures to the head (regardless of sides) total 1 minute and 20 seconds there have been 15 milliamperes for 80 seconds or 1,200 milliampere seconds. It is well to remember that 25 inches target film distance is about 15 inches target- scalp distance in the above example. Dental radiography uses short target film distances and the danger of skin damage would be considerable were it not for the small cone that confines the X-rays to a small area. Always inquire about previous X-ray exposure. If several films have been taken of the same region during the previous 30 days, it is advisable to wait until 30 days have elapsed since the last exposure. A point frequently overlooked is the risk of making skull and sinus exposures directly after a full set of dental exposures and vice versa. Radiation protection for the technician consists of keeping lead-lined walls or screens between the active tube and himself. Even with px-otected tubes such as shown in figxxres 187 and 201, this is the safest practice and the only protection against scattered or stray radiation. When assisting in the fluoro- scopic room or operating bedside units, technicians should wear long aprons impregnated with lead. This protects xxxost of the blood forming centers in the hones which are sensitive even to scattered radiation. Protective gloves should be worn if the duties require placing the hands nearer than 6 inches to the X-ray beam. While the amount of radiation absorbed by a technician in one day is usually small, a small dose repeated daily over a period of months amounts to an alarming total. Technicians may determine whether or not they ai'e absorbing dangerous amounts of radiation by the dental film method. Fasten two lead numbers, used for numbering films, to the exposure side of a dental film pack. This may be wrapped in one layer of black paper, for additional protection. Place the pack in a pocket with the exposure side out. After carrying for a full working day, develop and let someone not familiar with the numbers used inspect the film. If he can read the different numbers correctly on 3 of 5 films carried on 5 consecutive days, the technician is receiving too much radiation. There are several other methods of testing for radiation hut they require equipment that is not always available. The inside walls of radiographic and fluoroscopic rooms are xxsually lined with lead or coated with barium plaster to protect persons working habitually in adjacent rooms. The inside walls of rooms containing deep therapy equip- ment are usually lined with sheet lead of % inch thickness or more depending upon the kilovoltage used. If there are occupied rooms directly above and below, the ceilings and floors must also be protected. Electrical precautions. Only alert, mature individuals with good judgment should be allowed to operate equipment that involves risk of contact with high voltage. The habit 964 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY should be developed of looking and thinking before switches or push buttons are closed. Caution the patient not to move and do not allow spectators or attendants to approach any high-tension part. If the equipment has not been used for several days, or, in the case of bedside units, has been moved, it should be tested before the patient is placed in position. X-ray apparatus should not be accessible to anyone not responsible for its care and use. Accidents, breakdowns, and faulty performance frequently result from the curious tampering with controls and connections. A good working rule is to never allow the tube terminals or any other high- tension part to come closer to the patient than twice the distance of the point spark gap. To allow for line surges, this distance should never be less than 1 foot. When the secondary coil of the transformer is grounded in the middle, the voltage at each end of the tube is one-half the total voltage. Nevertheless, it is safer to observe the working rule and not develop habits that might be carried to other apparatus. Remember that the autotransformer control with the resistance “cut out” allows dangerously high amperage to be drawn from a transformer when the high-tension is grounded. Before approaching an X-ray tube or posturing a patient, see that the line switch and X-ray switch are in the “off” position. It will be recalled that timing devices and foot switches are merely convenient forms of X-ray switches. Any push button type of switch may stick and remain in the “on” position. For this reason it is safer to have the X-ray switch on a control stand connected in series with the timer and foot switch. The latter are then “dead” until the X-ray switch is thrown to the “on” position. Control stands with these devices con- nected in parallel are dangerous because a defective push button may close the circuit unbeknown to the operator. This is especially true of valve tube rectification whose operation is silent. To overcome this it is good practice to connect a warning light and buzzer in the primary circuit. When high-tension jumps from its proper path it does so because it has found an easier path to follow. This simple fact is not so simple in practice. The easier path may be ionized air, defective or damp insulation, a patient’s body, or a combination of these and several other factors. High-tension is always seeking a path to the ground. As a working principle, the path to ground through a patient’s or operator’s body should be made more difficult (contain more resistance) than some other paths that are not dangerous. It is generally agreed that tube stands should carry a ground wire con- nected to a water pipe if possible and that they should not be in contact with radiographic tables. The latter should have a poor conductor in contact with the patient (such as a wooden table top) and should not have a connecting ground wire unless they collect static. A heavy charge of static electricity collects on some X-ray tables. Fluoroscopic tables should be grounded because the patient is not between the tube and the table. Bedside units usually have a connection for a ground wire. This may be incorporated in the lamp socket connection of the unit for the low-tension wires will carry off a high-tension ground very efficiently. Otherwise, the ground wire should have a spring contact terminal that may be clamped to a radiator or waiter pipe. Never allow any part of the unit to touch the bed. See that the bed is not grounded by extension lights, radio ear phones, etc. Floor coverings of X-ray rooms should be nonconducting material such as linoleum or rubber composition. To prevent the accumulation of ionized air, such rooms should be well ventilated. X-RAY 965 X-ray protection. An Advisory Committee on X-ray and Radium Protection was formed in tlie United States for the purpose of preparing unified safety recommendations. The complete recommendations of that committee are published by the U. S. Depart- ment of Commerce in the Bureau of Standards’ Handbook, HB-20. The follow- ing excerpts from that publication are quoted: “2. Special requirements for apparatus of class a. (X-ray installations for diagnostic purposes at voltages up to 130 kv peak.) “b. peotection of patient “2.03. The equivalent of 1 mm. of aluminum shall be permanently mounted between the tube target and patient in all fluoroscopic tube inclosures and 0.5 mm. of aluminum in all radiographic tube Inclosures. Part or all of this may be contained in the glass of the tube walls. “2.04. The diaphragm of the tube container shall have a permanent covering of asbestos board at least 0.5 mm. thick placed between the tube and filter, next to the filter. “c. PEOTECTION OF PHYSICIAN AND PEESONNEL “Protection From Direct Radiation. “2.05. The fluorescent screen shall be covered with plate lead-glass having an equivalent lead thickness of at least 1.5 mm. “2.06. Protective gloves shall have an equivalent lead thickness of at least 0.5 mm., and shall insure protection to the whole hand—outer surface, palm, fingers, and wrist. “2.07. Protective aprons worn by the physician or technician shall have an equivalent lead thickness of at least 0.5 mm. “Protection From Scattered Radiation. “2.13. To protect the operator and personnel, control apparatus for radio- graphic work should be in an adjacent room which provides protection equivalent to at least 0.5 mm. of lead. Control operators should be behind such protection during all radiographic exposures, and during all radioscopic work when practicable. “2.14. When it is impracticable to place the control apparatus in an adjacent room, as in paragraph 2.13, it may be inclosed in a lead-lined booth within the radiographic room. “2.15. Either control room or booth shall be provided with a suitably large lead-glass window of 2.0-mm. lead equivalent. “2.16. The use of movable upright protective screens is dangerous and shall be discontinued. “2.17. When thermionic rectifiers are used they shall be either placed in a separate room or surrounded by material of 0.1-mm. lead equivalent. “10. high-tension leads to tubes “10.07. When using an X-ray tube having any exposed high-tension parts, the table shall be insulated from ground by suitable material capable of with- standing 3/2 the maximum working voltage to ground. “10.08. Metal parts of X-ray apparatus, such as tube stands, transformer tanks, motors, controls, etc., shall be permanently grounded to a water pipe through at least a no. 6 AWG wire or the equivalent. This wire must he suitably protected against accidental breakage. 966 HANDBOOK OF THE HOSPITAL CORPS, U. S. NAVY “IV. STORAGE OF X-RAY FILM “15. General “15.05. Smoking shall be prohibited in rooms where film is handled or stored. Conspicuous “No Smoking” signs shall be posted in prominent places. “15.06. No films shall be stored within 2 feet of steam pipes, radiators, chimneys, or other sources of heat. V. OPERATING RULES ‘16. Rules for technicians, nurses, etc. “16.01. A copy of these rules shall be given to every X-ray worker, whether temporary or otherwise, upon entering service. A signed receipt stating that the rules are understood shall be given to the physician in charge of the department. “16.02. A copy of these rules, together with a copy of first-aid instructions for electrical shock, shall be posted conspicuously in all principal X-ray rooms. “16.03. Protective gloves and aprons, even though in compliance with these recommendations, do not afford adequate protection. Consequently, care shall be taken at all times not to expose the body unnecessarily to radiation. “16.04. Lead rubber becomes hard and brittle with age, and all such pro- tection should be tested at regular intervals for possible cracks and imperfec- tions. This test should be made radiographically or radioscopically. “16.05. Radioscopic work should be performed in the minimum time pos- sible, using the lowest X-ray intensity and smallest aperture consistent with demands. It is important, however, that the fluoroscopist use sufficient X-ray intensity so that he can see without eyestrain. “16.06. The omission of any protective devices for the sake of expediency of operation shall be strictly forbidden. “16.07. Before touching any X-ray generator or high-tension part, particular care shall be taken to make sure that the main-line switch is open and the whole apparatus is disconnected from the power line. “16.08. In the case of equipment having high-tension condensers, care shall be taken that both sides of the high tension are actually and securely grounded before touching any part thereof. “16.09. If the transformer and controls are located in a remote room, a plaque reading “Do Not Touch” shall be hung over the main-line switch when it is necessary to touch high-tension parts in another room. “16.10. Where several appliances for treatment or examination may be con- nected to a common high-tension system, care shall be taken that conductors to all idle equipment are disconnected. “16.11. Where the machine operation depends upon two persons, a distinctly audible or visible signal shall be given by the operator before throwing on the high tension, and a return signal received from the person using the equipment. “16.12. Any acoustical or optical signal system for protective purposes should he checked daily before commencing work. “16.13. The main switch should be opened immediately upon completion of the X-ray work, or when the machine is not in actual use. “16.14. The high-tension overhead system should be examined frequently for possible faulty insulators or loose parts. “16.15. A daily check shall be made, to be certain that no idle flexible high- tension leads extend below the minimum prescribed height above the floor. “16.16. All grounding connections shall be examined weekly. X-RAY 967 “16.17. All high-tension barriers shall be examined frequently. When possible, this should be done when cleaning the apparatus. “16.18. In case of fire in the X-ray or control rooms, or in any part of the building, all X-ray apparatus should be immediately disconnected from the mains by opening the main power line switch. “16.19. All workers should be thoroughly familiar with the Schaefer prone pressure method of resuscitation in case of electric shock, and a set of such instructions should be posted conspicuously in each main room. Above the de- scription of the method should be placed the instructions: “ ‘This hospital may be provided with pulmotor or other resuscitation appara- tus. Do not wait to send for it, but proceed immediately with the Schaefer prone pressure method.’ “17. RULES FOE PHYSICIANS IN CHARGE “17.03. At least every 4 months each worker shall be supplied with a dental X-ray film half covered with lead foil, which shall be worn on the breast con- tinuously, with the film side out, for 15 working days. If, upon development, appreciable darkening of the exposed part of the film is indicated, the cause therefor shall be investigated and eliminated. “17.04. Circuit-breakers should be examined monthly to be certain that the overload adjustment is correct. “18. PERSONNEL WORKING CONDITIONS “18.03. Every assistant, technician, and operator should be given at least 4 weeks’ vacation a year with at least 2 weeks of this consecutively and during the summer months. “18.04. All persons occupied in radiological work should be examined for general radiation injuries yearly. Complete blood counts should be made fre- quently. The results of all tests and examinations should be permanently re- corded. It is advisable that all persons be carefully examined before entering radiological work.” References Manual of Roentgenological Technique.—Sante. U. S. Army X-ray Manual.—Pillsbury. Physics of Radiology.—Weatherwax. Roentgenographic Technique.—Rhinehart. Science of Radiology.—American College of Radiology. Wilhelm Konrad Roentgen.—Glasser. X-ray Protection.—Handbook. Bureau of Standards. No. 20. INDEX Abbreviations: Page In prescription writing 635 Of Latin words in pharmacy 635 Abdomen.. 52 Acute conditions of. 126 Abdominal: Cavity 52 Conditions, acute 1 126 Paracentesis 330 Abduction ..■ 24 Ablution, full. 921 Abscess-es. 87 Alveolar 172 Gum.. 173 Absorption.. 51,61 Acacia (gum arabie) 240 Accelerated reaction in vaccination 425 Accomodation, 82 Defects of. 82 Accountability, property 774 Hospital Supplies and m, vi, 774 Accounting 778 Officer , 774 Procedures 774 Records and reports 778 Acetabulum 21 Acetaldehyde 719 Acetic acid, poisoning by 266 Acetone 719 Acetophenetidin 225 Acetylene-s 722 Acidic oxides. 693 Acidimetry... 732 Aeid-s. 680 Acetic 720 Glacial 226 Acetylsalicylic 227 Amino 59,61,579,585 Anhydrides- 681 Ascorbic -... 63,582 Barbituric, derivatives of... 747 Base equilibrium 30,892 Bases, and salts.. 680 Benzoic 226,817 Binary 681 Boric. 709,817 Carbolic. (See phenol.) Carbonic 49 Cevitamic.. 582 Citric 226 Deflni tion of 680 Diethylbarbituric 257 Dibasic 683 Fixing bath 959 Aeid-s—Continued. Page Halogen . (581 Hydriodic... 691 Hydro 681 Hydrobromic 681,690 Hydrochloric 60,185,690 Hydrocyanic 684,871 Hydrofluoric 692,817 Hydrogen 681 Inorganic or mineral .... 683 M onobasic 683 Nicotinic 533 Nitric 186 Of phosphorus 703 Organic 225,720 And their esters 225,720 Poisoning by 267 Orthophosphorie ...... 703 Oxalic 266 Oxy 681 Oxygen.. 681 Picric. 224,364 Polybasic. 684 Prussic 871 Reaction 680 Salicylic.. 226,817 Salts 684 Sulfuric 186,700 Tannic ! 227 Tartaric. ...... 228 Ternary 684 Tribasie 684 • Uric (crystals) 891 Acidosis. 32 A conite 254 Poisoning by 263 Tincture 254 Acriflavine 364 Acromion process 20 Activated sludge process (sewage purification). 444 A dam ’sapple 47 Adduction r 24 Adeps. 238 Benzoinatus. 238 Lanse- - 238 Adhesion. 658 Adipose tissue n Administration: And general clerical procedures... ra, vi 749 Of— Medicines _• 180,304 Care of medicine locker 305 Conditions affecting 180,181 “Five Rights” in 304 Methods of 304 960 970 INDEX Administration—Continued. Page Of—Continued. Therapeutic treatments... 304,311 Application of heat and cold 311 Counterirritants.. 315 Enemata. 319 .Enteroclysis 321 Gastric lavage... 322 Gavage 322 Medicated baths 314 Adrenal (suprarenal) glands 62 Adrenalin. (See Epinephrine.) Agdes aegypti mosquito 340, 407, 412 Aeration of blood... 48 Agrobes 94,901 Aerobic bacteria 94 Aeronautics, Bureau of T 753 Aeroplane splint 163 Afferent nerves 72, 73 Agar 240 Agglutination 857 Tests.. 903 Agglutinins 32 Iso... I 857 Agglutinogens, iso- 857 Aid stations: Battalion, Marine Corps expeditionary force * 566 Regimental, Marine Corps expeditionary force - 566 Air; Atmospheric pressure 429 Carbon dioxide in 429 Composition of — 428,692 Embolism.. 879 Microorganisms in 431 Physical properties of 429 Relation to health 428 Residual _1 ... 5i Tidal— 51 Albuminuria 68 Alchemy 644 Alcohol-s.. 218,718 Dehydrated 219 Dilute — 219 Ethyl 218,719 Glycerin.. 218,219 Methyl .... 219,718 Poisoning by 264,718 Sponge bath 314 Alcoholism, acute: Bogan’s test in.. 125 Unconsciousness caused by .. 125 Aldehydes... — 220,719 And aldehyde derivatives 220 Alimentary canal (or tract) 51,64 Alimentation, duodenal 594 Aliphatic carbon compounds 714 Alkali-s ... 187,684,706 Caustic.. 187 Poisoning by 265 Elements and their compounds 187 Metals 706 Antidote for poisoning by 187 Hydroxides of 187 Alkali-s—Continued. Page Mild ,.. 198 Reserve. . 31 Alkalimetry. 730 Alkaline: Earth elements and their compounds. 198 Earth metals 708 Earths 934 Reaction 684 Alkaloid-s 248 Alkaloidal salts, and alkaloidal drugs 248 “Cadaveric” 248 Alkalosis 32 Allahabad system of excreta disposal 535 Allenes ■_ 722 Allergy.. m, v, 469 Atopy 469 Bacterial. _ 437 Categories of.' 459 Drug 486 Food ■ 477,591 Gastrointestinal 473 Physical 439 Serum. 433 To parasites and insects.... 439 Alligation 610 Allotment-s ... 779 Appropriational 779,730 Medical Supply Depot 779 Allotropicmodifications.: _ 694 Allotropism 694 Alteratives 177 Alternating current, modulated 930 Alum.. 203 Exsiccated 204 Aluminum 709 Compounds 203 Oxide 709 Alveolar process-es _ is, 52 Alveolus-i 167 Of lungs..---— 38,48 Ambulance party, ship’s landing force, mis- sion of 571 Aminoacids. 59,61,579,585 Amitosis (amitotic division; fission) 9 Ammonia 201 Aromatic spirit of 197 Water 196 Stronger 196 Ammoniated mercury . 210 Ammonium: Carbonate 197 Chloride 197 Ichthosulfonate 216 Radical 680 Amoeba 71 Amoebic dysentery 400 Amyl nitrite. .1 229 Amylaceous: And mucilaginous substances 238 Substances 239 Amylase - 60 Anabolism 9 Anaerobes - 94,901 INDEX 971 Page Anaerobic bacteria 94 Anaesthesia m, vi, 735 General 737 Inhalation 737 Intravenous 745 Rectal 745 Preanaesthetic medication 746,747 Regional 735 Infiltration and block 735,736 Spinal. 735,736 Surface. 735 Anaesthetics 177 Avertin 745, 747 Chloroform ...... 216,739,740 'Cocaine hydrochloride 735 Cyclopropane '. 739,740 Divinyl oxide 742 Ether 739,740 Ethyl chloride 217, 739, 742 Ethylene ... 739,740 Evipal soluble 745 Metycaine hydrochloride 736, 737 Nitrous oxide 739, 740 Nupercaine hydrochloride 736, 737 Pentothal sodium 745 Pontocaine hydrochloride 736,737 Procaine hydrochloride : 736 Anaesthetist: Table for ... 358 Anaesthetizing room 359 Anal orifice.. 55 Analgesics 177 Analysis 653 Chemical 724 Gastric 897 Gravimetric 731 Of— Adequate diet T. 587 Water, sanitary 440 Proximate 731 Qualitative 724, 731 Quantitative. 724,731 Ultimate 731 Volumetric.. 731 Analytical: Procedures 724 Reactions 732 Direct type. . 732 Indirect type. 732 Residual type 732 Anaphrodisiacs 177 Anaphylactic shock... 375 Anaphylaxis 376 Anastomosis 40 Anatomical positional terms 14 Anatomy: And physiology in, v, 5 Definition of - - — 6 Descriptive 6 Human 6 Microscopical (histology) 7 Surgical... 6 Topographical.. :.. 6 Page Ancylostoma duodenale (hookworm) 403,911 Aneurin (vitamin Bj; thiamin) 582 Angio-neurotic oedema 479 Angiology 7 Angstrom units 924 Anhydroties... .... . 177 Animal-s: Carcasses, disposal of 541 Foods * 588 Parasites . 907 Parasitology 907 Substances, products obtained from 245 Anions 669 Annual: Estimates 781 Purchase requisitions 782 Anode . 669 Anodynes 177 Anopheles mosquito. _ 408,446 Antacids 177 Ante-mortem statement ■_ 85 Anthelmintics 177 Antibody-ies 32,374 Antidote-s.. 177,260 For poisoning by alkali metals 187 Antiemetics 177 Antigen 32 Antimony 704 And potassium tartrate 207 Compounds _. 207 Antiperiodics 177 Antiphlogistics _... 178 Antipyretics .. • 178 Antiseptic-s. 178 Antisialiacs ...... . 178 Antispasmodics 178 Antisyphilitics 178 Antitoxins :... 32 Antrum... ... 16 Of Highmore 18 Aorta 40 Abdominal .= 41 Arch of 40 Ascending 40 Descending 41 Thoracic... 40 Aortic valve 37 Aperient J ... 178 Apertures, posterior nasal 16 Aphrodisiacs 178 Apncea .. - 51 Apomorphine 250 Aponeuroses 24 Apoplexy. 124 Apparatus: Lacrimal 81 Visual 81 Appearance: General, of patient 274 Of body of patient 274 Appendicitis, acute 126 Appendix,vermiform 55 Appropriations, annual 779,780 154294°—39 62 972 INDEX Page Aqueous humor. ■ 82 Arachnida (arachnids).... 913 Mites: Sarcoptes scabei.. 913 Spiders: Lactrodectus mactans (“black widow”).. 913 Ticks: Dermacentor andersoni 913 Dermaeentor variabilis 913 Ornithodoros moubta 913 Arachnoid membrane : 74 Areh-es: Deep volar 40 Dorsal venous. 44 Of aorta 40 Superficial volar... 40 Vertebral 19 Zygomatic -.. 16 Arithmetic, pharmaceutical 607 Army and Navy General Hospital 758 Aromatic-s 178 Bitters 178 Carbon compounds. 714 Fluidextract of cascara sagradse 245 Hydrocarbons __ 722 Spirit of ammonia 197 Arsenic. 704,817 Antidote for poisoning by 205,704 Compounds of 206,704 Poisoning by 264,704 Trioxide 206,704 Arsphenamine 206,505 Arterial injection (embalming) 883 Arterioles 38 Artery-ies 38 Aorta 40 Abdominal 41 Arch of.. 40 Ascending 40 Descending 41 Thoracic. 40 Axillary... 40 Brachial 40 Bronchial 41 Coeliae .-. 41 Common carotid. 40 Common iliac 41 Coronary 37 D orsalis pedis 43 External iliac 41 Femoral 43 Gastric 41 Hepatic 41 Hypogastric. 41 Innominate. , 40 Intercostal 41 Lumbar... 41 Mediastinal. 41 Meningeal 108 Mesenteric 41 GSsophogeal 41 Ophthalmic 81 Ovarian 41 Parietal 41 Pericardial. 41 Artery-ies—Continued. Page Peroneal 43 Phrenic 41 Popliteal. 43 Pulmonary.. . 33 Radial 39,40 Sacral, middle 41 Spermatic 41 Splenic 44 Subclavian 40 Tibial 43 Ulnar. 40 Vertebral 40 Visceral 44 V olar arches. 40 Arthrology 7, 44 Arthropoda 943 Arachnida. 943 Insects 943 Articular cartilage .. 45 Articulations, description of 22 Artificial: Cooling of air 433 Lighting 434 Respiration 424 Schaefer’s method of 424 Ultraviolet therapy 920 Ventilation 432 Ascarls lumbricoides (round or eel worm) 944 Ascorbic acid (vitamin C) 532 Aseptic surgery.. 300 Asphyxia 54,420 Artificial respiration in 424 Choking, treatment for 422 Hanging or strangling, treatment for 122 Poisonous gases.. 422 Resuscitation of apparently drowned 422 Treatment for 424 Asphyxiants (chemical warfare) 863 Aspirin 227 Assimilation.......... 9 Assistant Secretary of the Navy 750 Aster-s. 9 Rays 9 Asthma 473 Astigmatism '.. 82 Astringent-s. ... 473 Enemata 320 Atmosphere, gaseous content of :... 428,692 Atmospheric pressure 429,434 Atom-s. 646,942 Atomic: Number. 663 Structure.. 672 Weight 662 Atropine...: 252,747 Poisoning by. 264 Sulfate 262 Aural irrigations 333 Auricle; Of ear 82 Ofheart. .'. 37 Aurieulo-ventricular valve 37 Autoclave 362 INDEX 973 Page Autoeondensation 933 Autonomic nervous system 73 Autopsy. (See Postmortem examinations.) Autotransformer 951 Avertin (tribromethanol) .. 745,747 Aviation medicine m,vi,847 Avogadro’s hypothesis 656 Axone (axis cylinder process) 73 Bacillary dysentery 339,402 Bacilli... 901 Acid-fast, method of staining 902 Bacteria 374,901 Aerobic.. 94,901 Anaerobic 94,901 Dysentery group in food poisoning 377 Pyogenic 361 Reproductionof... 901 Salmonella group of 377 Saprophytic 436 Staining of 901 Bacterial allergy 487 Bacteriology 699,899 Bacteriolysins 32 Bacteriophage- 903 Balance-s: Acid base (equilibrium) 892 Care of 605 Chainomatic 605 Compound lever 605 Double beam, unequal arm 605 Single beam, equal arm 605 Single beam, unequal arm 605 Torsion 605 Balanitis 501 Balanoposthitis 501 Balantidium cob.... - 908 Balkan frame 157 Balsam of Peru.. 235 Bandage-s 131 And bandaging in, v, 131 Application of 132 Barton 138 Circular 133 Complete of hand 135 Cravat 141 Demigauntlet 135 Desault 104, 111 Figure-of-eight 134 Gauntlet 135 Handerchief 141 Many-tailed 140 Neckerchief. 141 Oblique ,.. 133 Of— Back 142 Extremities 134 Eye 139 Fingers 135 Groin 136 Head... 138 Heel.. 136 Hip.... 146 Jaw 138 Shoulder 136 Stump 133 Bandage-s—Continued. Page Plaster of Paris.. . 140 Recurrent 133 Of head ,. . 433 Removal of 133 Roller 43j Sayre dressing . _. 439 Spica 138 Ascending .... i36 Descending.. 435 Spiral 133 Reverse 435 “T” 140 Triangular 444 Velpeau 437 Bandaging 131 General rules for... 432 Barbital ... 256,257 And related compounds 256 B arbiturie acid derivatives 747 Amytal 747 Pentobarbital. 747 Pentothal sodium 745 Phenobarbital 257 Sodium cyclural (evipal soluble) 745 Barium. 703 Compounds.. 201 Dioxide 201 Sulfate. 201 Barton bandage 433 Basal; Conditions 352 Metabolic rate (B. M. R.) 354 Factors influencing 354 Relation of to height, weight, surface area, age, sex 352 Metabolism in, vi, 849,853 Apparatus for determining 853 Clinical significance of 855 Technique 854 Bases..... 680,684 Dihydric . 685 Hydroxides of 684 Monohydric 685 Basic: Lead carbonate ....... 711 Salts 685 Basophiles 36 Basswood splint 164 Bath-s: Acid fixing 959 Alcohol sponge 314 Bed. 298 Cleansing 298 Cold 313,921 Rules in administering 313 Continuous tepid 921 Contrast. 922 Electric light 925 Foot 312 Hip 922 Hot 311,921 Hyperpyrexia 921 Medicated.... 314 Paraffin 922 974 INDEX Bath-s—Continued. Page Sheet 921 Sitz 313,922 Sponge 298 Towel 921 Whirlpool 923 Bed-s and making of ... 290 Changing- Lower sheet of a bed patient 291 Mattress 291 Cleaning and airing..... 290 Ether 292 Fracture 292 Turning mattress with patient in bed 292 With patient in bed 290 Bedbug-s (Cimex lectularius) 450 Control measures for 450 Bedpan 303 Bedsores (pressure spots) . 299 Beef, as food 588 Cuts of 829 Belladonna: Extract of.. 251 Leaf ..... 251 Poisoning by 265 Benedict’s qualitative solution 890 Benzene... 714,722,724 Ring 714,722 Benzine, poisoning by, 269 Benzoic acid 226 Benzoin, compound tincture of. . .. . 235 Benzoinated lard ... ..238 Beryllium ..... 708 Bicarbonate of soda _ 190 Bichloride of mercury 210, 264 Disinfectant 451 Poisoning by. 265 Sterilization by 363 Bicuspid: Teeth 52 Valve (mitral) 37 Bile 56,60 Duet, common 56 Biliary ducts 56 Bilirubin v 56,899 Bill of Health. _ ... 454 Binary compounds 679 Biology .. 7,599 Bismuth _ ... 704 And potassium tartrate 209 Compounds 208 Subcarbonate ... 208 Subnitrate 208 Subsalicylate 208 Bitters 178 Aromatic 178 Simple . 178 Bladder: Gall 56 Irrigation 327 Urinary 68 Blank forms, medical department 773 Blanket count.... 346,350 Blaud’s pills 205 Page Blood. 29 Acid-base equilibrium (balance) 30,892 ASration of 38,40 Agglutination 857 Alkali reserve 31 And blood vascular system 29 Cells ........ 29 Corpuscles.. 29 Counting of 36,905 Crenated.. 35 Polymorphonuclear 36 Red 29,33 Schilling classification of 906 White... 35 Chemistry 891 Circulation of. 38 Clot (coagulum) 33 Coagulation and time of 33,906 Composition of 29 Count: Complete. 905 Differential.. 36,905 Red cell ... 905 White cell. 905 Cultures 902 Deoxygenated 50 Donor, selection of.. 862 Formed elements of. .... 33 Functions of 29 General description of 29 Grouping and matching . __ 111, vi, 856 Classification in .' _ 859 Cross matching 860 Precautions in j.. 861 Technique of 858 Occult 891 Oxygenated 49 Plasma. 29,30 Platelets (thrombocytes) 29,36 Poisoning. (See Septicaemia.) Pressure. 39,281 Apparatus (sphygmomanometer) 281 Sedimentation test ... 906 Serum 33 Transfusion.. _ 856 Vascular system... .. 29,36 Vessels .( 36,39 Blue ointment ... . 212 Bodies, foreign, removal of 118 Body wastes: Alimentary canal (faeces) . 64 Elimination of . 63,302 Lungs (expiration) 63 Skin (perspiration) _ 63,68 Urinary system (urine) 63,303 Boil, or furuncle .... 87 Boiling 616 Point of substances 695 Bone-s 12,14 Anatomical description 14 And joints ... 14 Atlas 16 Calcaneus 22 Capitate. 21 INDEX 975 Bone-s—Continued. Page | Carpal 21 Clavicle 20 Coccyx. 19 Composition of 14 Cuboid... 22 Cuneiform 22 Ethmoid 17 Femur 21 Fibula.. .: 22 Frontal ... 17 Greater multangular 21 Hamate 21 Humerus 20 Hyoid 18 Incus 17 Inferior turbinated 18 Innominate , 21 Lacrimal 18 Lesser multangular 21 Lunate ..... 21 Malar 18 Malleus ...... 17 Mandible 18 Marrow.. 15 Giant cells of 36 Maxillae .-. 18 Metacarpal 21 Metatarsal 22 Nasal 18 Navicular; Of foot . 22 Ofhand , 21 Number and distribution 15 Occipital 17 Of— Cranium 17 Ear 17,83 Face 17 Lower extremity.... 21 Neck and trunk 18 Pelvis 21 Skeleton ........ 15 Spinal column... 18 Thorax 19 Upper extremity 19 Palate. 18 Parietal 17 Patella 21 Phalanges 21,22 Pisiform 21 Radius... 20 Ribs (false, floating, true). 19 Sacrum ... 19 Scapula -.. 20 Sesamoid.. 15 Shapes of._ 15 Sphenoid. 17 Stapes. — 17 Sternum 17 Sutures of 16 Talus v 22 Tarsal 22 Temporal. 17 Bone-s— Continued. Page Tibia 22 Triangular.. 21 Ulna. 20 Vertebrae (true) ... 18 Vomer 18 Words used in describing 16 Zygoma 16 Bony labyrinth of ear 83 Boric acid 185, 709,817 Boron 185,708 Borrelia: Duttoni 913 Recurrentis 916 Botany ...7,599 Botulism 379 Bowman’s capsule... 66 Boyle’s law 655 Brachial: ■ Artery 40 Plexus 78 Vein. 44 Brain 72,74 Arachnoid membrane 74 Cerebellum 75 Cerebrum 74 Compression of 124 Concussion of 124 Corpus callosum '... 75 Cortex cerebri 74 Dura mater 74 Forebrain ' 74 Gray matter ... 74 Hindbrain 74 Meninges - 74 Midbrain 74 Piamater.... .. 74 Subarachnoid space 74 Ventricles 75 Lateral (two) 75 Fourth 75 Third 75 White matter. 74 Breath, odor of 276 Bright’s disease 125 British thermal unit (B. T. U.) 693 Brittleness, definition of 654 Brombenzylcyanide 863 Bromine 689 Bronchi and Bronchus 48 Bronchioles 48 Bubonic plague 409 Buffer solutions 730 Buffers 30 Bulbo-urethral glands (Cowper’s) 70 Bureau-s, Navy Department: Aeronautics 753 Construction and Repair 751 Engineering 752 Medicine and Surgery 752 Appropriations annual 780 Assistant chief of 759 Chief clerk of 759 Chief of 759 976 INDEX Bureau-s—Continued. Page Divisions of 759 Duties of 752 Finances of... 774 History of 755 Organization of 755 Navigation 751 Ordnance 751 Supplies and Accounts 752 Titles of head of 750 Yards and Docks 1 751 Burns: And scalds 116 Treatment of 116 Secondary to screening smokes and white phosphorus 866 Cadaveric: Alkaloids 248 Lividity.. 837,838 Caecum 55 Caesium 708 Caffeine: Citrate 255 Withsodiumbenzoate 255 Caisson disease (bends) 431 Calamine, prepared 203 Calcination 616 Calcium 580, 708 Amount required in diet 680 Carbonate 201,708 Chloride. 200 Compounds 199 Conditions caused by lack of 580 Gluconate. 201 Hydroxide.. 200 Lactate 201 Oxide 708 Calculus, dental. 170 Calomel.. 210 Calorie-s: Definition of 583,614,693 Large (kilo-) 524, 583, 614,693, 850 Small 614,693 Yielded by foods 624,583,818 Calorimetry: Direct and Indirect 853 Calx (lime) 199 Chlorinata (chlorinated lime) ? 442.462, 530 Camphora 232 Camphorated tincture of opium 249 Canal-s: Alimentary 51,64 Central 77 External auditory 16 Haversian..... 15 Medullary 14 Semicircular, of internal ear 83 Canaliculi 81 Canning, in food preservation 817 Oantharidal: Collodion 318 Plaster.. 318 Capillaries 38 Lymphatic 46 Capillarity 658 Capsule-s: Page Bowman’s. 66 Joint 22 Carbhsemoglobin 35,49 Carbo activatus 184 Carbocyclic series , 714 Carbohydrates .. 580,720 In foods. 58O Or sacccharides 721 Sources of 58O Carbolic acid. (See Phenol.) Carbon 184,705 Activated charcoal 184 Compounds: Aliphatic or open-chain series of 714 Aromatic, carbocyclic, or closed-chain series of.i.. 714 Chemistry of. 713 Structure and structural formulas of 714 Dioxide 49, 429, 705, 876 Disulfide.. 705 Monoxide 429,706,871,876 Tetrachloride.. 217 Carbonic acid 49 Carbonization 616 Carboxidegas 452 Carbuncle. 87 Cardiac; Cycle 37 Depressants 173 Orifice of stomach __ 54 Plexus 79 Stimulants ..... 173 Care and comfort of patient 288 Care of the dead 838 Appropriation... 78O Care of the feet.. 562 On the march 502 Caries, dental 171 Carminative-s 178,320 Carrier 372 Cartilage: Articular is Tarsal... .. 81 Cascara sagrada: Aromatic fluidextraet of 246 Fluidextract of 245 Casein 60 Caseinogen. 2 60 Castor oil 236 Catalyst (catalytic agent) ..... 58, 687 Catalytic action 53 Cathartic-s i7g Aperients. 178 Cholagogues 178 Hydrogogues 178 Laxatives 173 Purgatives 178 Drastic 178 Saline 178 Simple 178 Catheterization 326 Articles required for urinary 326 INDEX 977 Catheterization—Continued. Page Procedures in urinary 326 Cathode. 669,942 Cations.. 669 Cauda equina 77 Caustics 264 Cavity-ies: Abdominal 52 Buccal - 51 Cranial 16 Glenoid.. 20 Injection (embalming) 885 Nasal 16 Oral... 16 Orbital 16 Pulp .' 167 Tympanic 52,82 Cell-s. .* — 7 Aster rays 9 Asters..... 9 Blood 29 Counting of 905 Body 7 Centrosome 8 Chromatin 8 Connector ; 71 Cytoplasm 7 Differentiation 9 Fertilization 9 Growth 8 Irritability (excitability) 8 Motor (effector) ... 71 Nucleus 8 Reproduction. 9 Segmentation 1... 9 Sensory (receptor) 71 Simple 7 Specialized 8 Spindle 9 Undifferentiated 7 Wall 8 Cementum 169 Census report of patients 346 Centigrade thermometer 614 Central: Canal 77 Lobe (Island of Reil) 75 Nervous system 72, 74 Sulcus, brain 75 Centrosome 8 Cephalin (thrombokinase) 33 Cerates (cerata) 629 Cerebellum 75 Fissure, horizontal 76 Hemispheres of 75 Vermis (middle lobe) 76 Cerebral: Depressants 178 Excitants 178 Nerves. (See Cranial nerves.) Cerebrospinal: Fever r 383 Fluid 75,77 Nervous system 72,74 Page Cerebrum 74 Convolutions 74 Fissure-s of 74 Central sulcus 75 Great longitudinal 74 Lateral cerebral . 75 Of— Rolando (central sulcus) 75 Sylvius (lateral cerebral) 75 Parieto-occipital 75 Transverse 75 Function oL ... . 75 Lobes of . 75 Cervical; Pleura - - 49 Plexus 78 Vertebrae 18 Cestodes (tapeworms) 909 Diphyllobothrium latum '.... 910 Hymenolepis nana r 910 Taenia saginata; and solium 909; 910 Chancre 493 Chancroid 414; 495 Channel-s, venous 43,44 Characteristics and properties of matter 653 Charcoal, activated 184 Charge register 776 Charles’ law . 656 Charting, clinical 293 Chemical: Affinity, definition of 664 Change —- 652 Compound 679 Compounds, nomenclature and classification of 679 Disinfection 451 Bichloride of mercury 451 Chlorinated lime 452 Formalin .. 451 Phenol (carbolic acid) 451 Equations 673 Formulas 661 Incompatability 636 Notation .. 660 Preparations 624 Preservatives of food 817 Solutions 659 Sterilization 362 Symbols.. 661 Venereal prophylaxis 513 Warfare in, vi, 862 First-aid treatment 863, 866,867,868,869,871 Medical aspects of 862 ' Physiological action of agents . _ 863,866,868,871 Summary of symptoms and first-aid treat- ment of casualties caused by exposure to agents 864 Chemistry . in, vi, 599,643 Acids 680 Analysis 724 Atomic weight 662 Atoms. 646 Structure of .. 646 Bases 680 978 INDEX Chemistry—Continued. Page Blood. —. 891 Compounds 653 Binary 679 Naming of 681 Ternary. 679 Definition of 651 Elements 660 Acid forming 681 Table of 660 Inorganic 651 Definition of 661,659 Laws and theories 653 Molecular weight ... 663 Molecules. 646 Nomenclature 679 Organic, definition of 651,713 Physical change 652 Polyvalence 665 Salts 680 Synthesis. 6,653 Valence 661 Weights, atomic, table of 660 Cheyne-Stokes respiration 283 Chicken pox 338,421 Chief of Bureau of Medicine and Surgery, duties of... 759 Chief pharmacists (commissioned warrant officers) appointment of . 760,762 Chilblain. 118 Chilling 117 Chills. 130 Chloracetophenone ... 863 Chloral hydrate 221 Chloramine-T ' 218,364 Chlorine . 442,689,866,875 Family of elements, .. 689 Chloroform (trichloromethane) 216, 718, 739,740 Chlorophyll 5 Chldrpicrin 866 Cholagogues — 178 Cholera 339,399 Choroid 82 Chromatin 8 Chromosomes 9 Chyle 45 Chyme 60 Cilia 47 Ciliary: Muscle. 82 Process 82 Cimex lectularius (bedbug) 450,550 Cinchona 250 Compound tincture of 251 Cinchophen 229 Circulation: Collateral- 40 Of blood 38 Portal. A. 45 Systemic, veins of. 43 Citric acid— 226 Clarification 621 Clavicle 20 Fracture of Ill T-splint for fractured 162 Page Cleaning .. 372 Gear 349 Of operating room .' 359 Of wards 347 Clerical: Force, organization of in naval hospitals 773 Procedures, administration and general-m, vi, 749 Work, medical department 763 Clinical: Chart (NMS Form Q) 284 Notes (NMS Form No. 17) 285 Record (NMS Form No. 59) 285 Recording and charting 283 Thermometer 278 Clonorchis sinensis (liver fluke) 909 Clostridium: Botulinum (Bacillus botulinus) .. 379 Histolyticum (Bacillus histolyticus) .... 95 CEdematiens (Bacillus oedematiens) 95 Sporogenes (Bacillus sporogenes) 95 Tetani (Bacillus tetani) 95, 340,361, 426 Welchii (Bacillus welchii; “gas bacillus”) . 95,361 Clothing: Color of 446 Disinfection of 451 Of patients . 354 Purpose of 445 Where obtained 445 Coagulation (clotting) .. 33 Chemical factors in .' 33 Physical factors in 33 Time . 33,906 Coagulum (clot) 33 Coaptation splints 107,164 Coca (Erythroxylin) . 254,637 Cocaine. 255,637 Hydrochloride 255,735 Poisoning by r 265 Cocci. 901 Cochlea ■ - 83 Cockroaches 1... 651 Control measures 651 Cod liver oil 237 Codeine 250 Sulfate — 2.50 Cohesion.. 658 Colation (straining) 6 Cold: Applications 311 Bath 921 Common, symptoms and treatment of 129 Compresses 318,920 Injuries due to. 114,117 Packs. 313,920 Purposes for which applied 311 Quartz lamps 926 Use of, in food preservation 816 Colic: Gall-stone 127 Kidney-stone.. 128 Collapse. 325 Collecting stations, Marine Corps expedi- tionary force , 567,569 INDEX 979 Page Conservation of matter, law of 654 Constant proportions, law of 652 Construction and Repair, Bureau of 751 Contact — 3.72 Beds (sewage purification) 444 Dermatitis ... 481 Contusion. 101 Conus medullaris 77 Convection.. 429 Convulsions.. 130 Copper 581,709 Amount required in diet 581 Anaemia caused by lack of 581 Compounds 214 Sulfate, sterilization of water by.. .. 214,442,710 Coracoid process 20 Cerium 28 Cornea 82 Cornstarch 239 Corpora cavernosa 70 C orpus spongiosum 70 Corpuscles: Blood...... 29 Renal 66 Correctives.. 178 Correspondence , 763 Classes of 763 Confidential .. 764 Examples of 768 Filing and files 772 Methods of handling '764 Official 763 Restricted... 764 Secret... 764 Corrosive-s: Mercuric chloride 211 Poisoning by 266 Poisons 258 Cortex: Cerebri 74 Of— Kidney 65 Suprarenal (adrenal) glands 62 Cortin 63 Corynebacterium diphtheriee (Bacillus diph- therias; Klebs-Loefller bacillus) 342,384 Costal pleura. 49 Cotton, used for clothing 446 Cottonseed oil 236 Coughs 275 Counter irritant-s 315 Cold as.. 315 Escharotics 315 Rubefacients 315 Vesicants 315 Cowling’s rule 180 Cramps, heat 114 Cranial nerves; Distribution of 78 Function of 78 Table of — - 78 Varieties of 78 Cranium: Bones of 17 Description of... 16 Collection: Page And disposal of refuse, ashore 445, 534 Of specimens. (See Specimens.) Colies’fracture 111 Collodion-s (collodia) 625 Cantharidal 318 Corn 564 Colloids 622 Colon: Ascending , 54 Descending 54 Transverse 54 Combustion. 693 Commensalism 907 Comminution 617 Commissary: Clerk, naval hospitals, duties of 805 Department, naval hospitals 804 Accounting and accountability 815 Civil employees, Civil Service status of.. 806 Organization of. 805 Personnel, duties of. 805 Physical arrangement of 807 Ledger 777 Officer, naval hospitals, duties of 804 Steward, naval hospitals, duties of 805 Supervision m, vi, 804 Common: Bile duct... •- 56 Carotid artery 40 Cold, symptoms of and treatment of.. 129 Iliac artery — 41 C ommunicable diseases 383 And practical preventive medicine 371 Definition of 335 Modes of transmission. 372 Nursing care of. 335 Source of infection 372 Compound-s: Binary 679 Chemical 679 Dislocation 104 Fracture 105,106 Ternary, — 679 Compresses 920 Cold ... 318,920 Hot 920 Compressibility, definition of 654 Compression 918 Of the brain 124 Concurrent disinfection. 336,372 Concussion of the brain. 124 Condiments 579,686 Condition-s: Abnormal, of eyes, ears, nose, mouth and throat 275 Acute abdominal 126 Heart 276 Mental, of patient 275 Conduction 429 Condyle-s 16,21,22 Conjunctiva.. -r 81 Connective tissue 11 Forms of 11 Conservancy, field 533 Conservation of energy, law of 655 980 INDEX Page Creosote 224 Carbonate .- 225 Crepitus 106 Cresol 223 Saponated solution of 224 Crisis.. 280 Crystallization 621,659 Definition of 621 Interstitial water 622 Mather liquor... 622 Water of 622,695 Crystalloids 622 Crystals... 621 Cubic centimeter 603 Culex mosquito 446 Culicid8D_ 914 Culifuges 547 Culture media 899 Sterilization of 900 Cupping 318 Current: Alternating, modulated 930 Faradic 930 Surging 930 Galvanic 929 Interrupted 930 High-frequency 931 General diathermy 932 Monoterminal 932 High-voltage, secondary 945 Induced 946 Low-voltage, primary 950 Sinusoidal, slow 930 Surging and interrupted 930 Cusps: Of- Teeth 167 Valves of heart 37 Cutaneous membrane 29 Cuticle , 69 Cutis vera 69 Cutting of meats 825 Cyanides, poisoning by... 265 Cyanogen. 706 Radical...... 680 Cyclopropane 739,740 Cystic duct 56 Cytology. 7 Cytoplasm.... 7 Daily ward duties 345 Blanket count 346 Cleaning schedules 347 Dakin’s solution 363 Dalton’s law 652 Darkfleld examinations ... 903 Dead: Care of the 838 Identification of the 840 Property of the 834 Death-s: And medico-legal matters. in, vi, 833 Conduct of hospital corpsmen in presence of. 833 D y ing declarations 836 E arly signs of 836 Death-s—Continued. Pag6 Later signs of 837 Signs of ..... 837 Unnatural causes, conduct in 839 Decantation... 620 Decoctions (decocta) 625 Decomposition 6 Double (metathesis) 674 Defsecation -. 51 Deflagration 616 Deglutition (swallowing) 51 Degree-s: Centigrade j 614 Fahrenheit 614 Of burns 116 Reaumur. 614 Thermometric; Conversion of, rules for 615 Seales used in marking 614 Deliquescence 622 Deliriants 178 Delirious patient, nursing care of 343 Delirium 343 Causes 343 Tremens 343 Types of 343 Delousing .... 372 Demulcents 178 Dendrone ..: 73 Dengue 407 Density. 607 Dental: Calculus 170 Caries 171 Corps 752 First-aid 171 Haemorrhage 173 Pain 172 Pulp 167 Records. 166 In identification of dead 840 Tissues 166 Treatment, emergency m, v, 165,171 Dentin 167 Deodorants 178 Department of the Navy 749 Assistant Secretary of the Navy 750 Bureaus of 750 Judge Advocate General of the Navy 763 Office of Naval Operations 761 Major General Commandant, U. S. Marine Corps 754 Secretary of the Navy 750 Depressant-s; Cardiac. 178 Cerebral.. 178 Derma 69 Dermacentor andersoni; and variabilis (ticks) _ 913 Dermacentroxenus riekettsi 913 Dermatitis, contact 481 Dermatoses, trade or occupational 516 Desault bandage. 104, 111 Desensitization. 376,485 Desiccation 616 981 INDEX Page Dextrose 242 Diabetes 63 Diet in 591 Dialysis 622 Dialyzer. 622 Diaphoretics 178 Diaphragm 26,28 Potter-Bucky 957 Diarrhoea .... 129 Diastole 37 Diathermy: General 932 Short-wave 933 Ultra short-wave 935 Dibasic acids 683 Dicrotic pulse 281 Diet-s: Adequate— Analysis (composition) of 587 Menu arrangement of foods in 588 Allergies. 591 Anaemia... 591 And messing for the sick... in, vi, 579 Balanced, determination of. 585 Cardiac * 591 Classification of in naval hospitals 593 Constipation 591 Diabetes 591 Diarrhoea 591 Elimination. 489 Fevers 592 Gastric ulcer 591 Gout 592 Karell. — 592 Lenhartz 591 Light - 593 Liquid 593 Long Island College Hospital ... 591 Names of 591 Nephritis 592 Obesity 592 Planning of 590 Regular 593 Serving of 590 Sippy 591 Soft 593 Special 593 Therapy 579,590 Tuberculosis 592 Dietetics, definition of 579 Diethylbarbituric acid 257 Differential blood count 905 Digestants.— -.. 178 Digestion... 51 Absorption 51,61 Defsecation 51 Deglutition r 51 Insalivation 1 51 Mastication 51 Peristalsis 51 Pharmaceutical 623 Process of 57 Digestive: Page Ferments . 58 System. 51 Digitalis 244 Poisoning by 265 Tincture of 244 D ihydric bases 685 Dihydroxybenzene: meta, ortho, and para 723 Diphenylaminechlorarsine 863 Diphenylchlorarasine 863 Diphtheria- 384 Diphyllobothrium latum (Russian tapeworm) 910 Diplococcus: Intracellularis meningitidis 342,383 Pneumoniae (pneumococcus of Fraenkel) _ 341.361 Disaccharides 721 Disease-s: Apoplexy 124 Appendicitis, acute 126 Autointoxication. 129 Balanitis 501 Balanoposthitis. 501 Beriberi 582 Bright’s 125 Caisson 431 Cerebrospinal fever 383 Chancroid 414,495 Characterized by a skin eruption 337 Chicken pox 338,421 Cholera 339,399 Communicable, and practical preventive medicine 371 Dengue 407 Diptheria 342, 384 Due to animal parasites, list of Important.. 917 Dysentry: Amoebic. 400 Bacillary 339,402 Empyaema 341 Epididymitis. 498,501 Epilepsy 123 Erysipelas.....' 341 Food deficiency 818 Gall-stone colic. 127 Genitourinary and venereal m, v, 490 German measles 337, 386 Gonorrhoea 414,496 Gonorrhoeal ophthalmia 332, 502 Herpes 296, 504 Hookworn (Ancylostomiasis) . _. 403 Influenza 341,387 Injuries, and abnormalities of the male geni- talia 490 Kidney-stone colic 128 Lymphogranuloma venereum (inguin- ale) 415,503 Malaria 339,408 Measles 337,388 Meningitis (cerebrospinal fever) 342,383 Mumps 390 Of— Lower animals transmissible to man 419 Respiratory tract 341 982 INDEX Disease-s—Continued, Page Paraphimosis 491 Paratyphoid fever 404 Pellagra... J 583 Phimosis 491 Plague (bubonic, pneumonic, septicaemia),. 409 Pneumonia, acute lobar 341,391 Prostatitis 498,502 Rabies 419 Resulting from an abrasion of skin or mucous membrane 340 Rickets 583 Ringworm 418 Scabies 413,913 Scarlet fever 337,392 Scurvy.. .: 682 Septic sore throat 393 Smallpox 338,422 Stricture of urethra 499 Symptoms of 273 Objective 274 Subjective 274 Syphilis 416,493 Tetanus 340,426 Trachoma 427 Transmitted by— Direct contact 413 Discharges from intestinal tract . _ 338,399 Discharges from mouth and nose 383 Insects and other arthropods 339,407 Trichinosis 420 Tuberculosis: Other than pulmonary 396 Pulmonary. 342,394 Typhoid fever. 338,406 Typhus fever 340,411 Uraemia 68,125 Venereal 492 Prevention of m,v, 511 Verruca acuminata, venereal 604 Vincent’s infection, oral 174 Water-borne... : 437 Whooping cough 397 Xerophthalmia 581 Yellow fever 340,412 Diseased tissue specimen-s, collection of 288 Disinfectant-s 178 Disinfection 372,450 Bichloride of mercury 451 Boiling 451 Burning. 461 Chemical 451 Chlorinated lime 452 Concurrent— 336 Distinction from fumigation 450 Formalin •... 451 Phenol (“carbolic acid”) 451 Physical 451 Steam... 451 Sunlight 451 Terminal.. 336 Disinfesting 373 Dislocation-s , .... 102 Complicated 105 Compound. 104,105 Dislocation-s—Continued. Page Elbow.. 104 Finger joints 103 Hip 104 Jaw. 103 Knee 104 Reducing of 103 Shoulder 103 Kocher’s method of reduction.. . 104 Reduction by traction or extension 104 Stimson’s method of reduction 104 Symptoms of. 102 Treatment of 103 X-ray examination in 103 Dispensaries. 760 At Marine Corps posts 565 Dispensary, IT. S. Naval, Washington, D. C _ 763 Dispensing 637,835 D ispensatory 601 Disposal: Of— Refuse ashore 445 Sewage ... 442 Wastes 542,673 Dissociation 674 Distillation 617 Destructive 617 Fractional. 617 Vacuum ... 617 Distilled water 183 Diuretic-s 178 Diving and submarine duty.. m, vi, 872 Divinyl oxide. 742 Donor, blood, selection of 862 Dorsal vetebrse. (See Thoracic vertebra.) Dose-s: Adult (normal).. 180 Average 180 Cowling’s rule for computing 180 Factors affecting 180 Lethal 180 Maximum 180 Minimum. 180 Therapeutic 180 Toxic. 180 Young’s rule for computing 180 Double: Decomposition (metathesis) 674 Salts. 685 Douche-s: Eye 330 Fan. 923 Jet 923 Pharyngeal 334 Scotch 923 Drainage, duodenal 898 Dressing-s 95 Antiseptic- 95 Aseptic. 95 Dry 95 Sterile i.. 95 First-aid packet . 95 Kinds of 95 Occlusive.. 95 Station, shore patrol... 575 INDEX 983 Dressing-s— Continued Page Surgical 327,364 Emergency outfit of. 365 Sterilization of 364 Tray or carriage..I 329 Wet 95 Antiseptic 95,97 Hot 95 Drowning. (See Asphyxia.) Drug-s.. 177 Administration of. ... 180 Conditions influencing 180 Allergy 486 Book, ward 346 Containing cathartic principles and their preparations.... 245 Inorganic. 181 Organic 215 Therapeutic classification of 177 Toxicology of 263 Drum, ear 82 Drying, in food preservation 816 Ductility, definition of 654 Ductus deferens (vas deferens) 70 Duodenal: Alimentation 594 Drainage 898 Duodenum 54 Dura mater 74 Duty-ies: Diving and submarine in, vi, 872 Independent m, vi, 887 Of— Bureau of Medicine and Surgery 757 Hospital corpsmen; Administrative and clerical. 763 At sick call ----- 347 In— Care of patients 273 Care of property and stores 350,783 Preparation of reports 763 Property accountability 775 Sanitary investigations 887 On recruiting , 936 Personnel, naval hospitals 805 With— Marine Corps expeditionary forces... in, vi, 564 Ship’s landing force 571 Shore patrol 574 Dying declarations 836 Dysentery: Amoebic 400 Bacillary.. 402 Group in food poisoning 379 Dyspnoea —. 51,283 Ear. 82 Ache 130 Drum. 82 External 82 Internal. 83 Middle.. 82 Ossicles (bones) 17,83 Removal of foreign bodies from 119 Treatment of conditions of 333 Page Eberthella typhosa (Bacillus typhosus) 338 Ebullition eig Ectoparasites.. 907 Eczema 479 Effective temperature in submarines 874 Effects, patients’ 354,834,835 Efferent nerves. 72,73 EfHeurage (stroking) 917 Efflorescence 622 Eggs, as food 589,811 Recipes for preparation of., 594 Ejaculatory duct 70 Elasticity, definition of 654 Elbow, dislocation of 104 Electric: Current 667 Light baths 925 Pads.... 316 Shock. 123 Electrocardiogram. 881 Electrocardiography m, vi, 879 Instruments 879 Technique... 880 Electrochemical (electromotive) series 687 Electrocoagulation 935 Electrodeless high frequency induction lamps. 927 Electrodes 880,929 Electrodesiccation i 936 Eleetrodiagnosis- 931 Electrolysis— 669 Electrolytes 669 Electrolytic dissociation 670 Electronic theory.. 667 Electrons 650,669,942 Electrosection 936 Electrosurgery. 936 Electrotherapy „ 928 Element-s 659 Electrochemical series of 687 Periodic- Arrangement of (fig. 149) 648 Classification of 649 Table of 650 Table of 660 Elimination diets in food allergy 489 Elixirs (elixiria) . . 625 Elutriation 618 Emblaming in, vi, 882 Arterial injection 883 C a vity injection 885 Fluid - 886 General instructions 885 Embolism, air 879 Embryology 7 Emergency: Dental treatment m, v, 165 Splints 164 Sterile operating outfit 365 Emetic-s 178,260 Emetine hydrochloride. 254 Emprosthotonos 268 E mulsions (emulsa) 625 Enamel - 167 984 INDEX Page Endamoeba histolytica 400,907 Endocardium 37 Endocrine (ductless) glands 29,61 Endolymph.. 83 Endoparasites.. 907 Endothelium 28 Enema-ta (clyster): Evacuant 319 Equipment for giving 319 Soap-suds... 319 Method of giving. 319 Object of giving 319 Retention 320 Astringent... 320 Carminative 320 Nutritive 320 Purposes for which given. 320 Sedative 320 Energy 654 Kinetic 654 Law of conservation of.. 655 Potential 655 Radiant 924 Engineering, Bureau of 752 Enterobius vermicularis (pin or seat worm).. 912 Enteroclysis .• 321 Enterokinase 60 Enzymes 51,58 Action of. 58 Amylase 60 Classes of 58 Composition of 58 Erepsin 60 Invertase 58,59 Lactase 58,59 Lipase 59,60 Maltase 59 Pepsin 60 Ptyalin 59 Rennin.. 60 Trypsin 60 Table of 59 Eosinophiles 36 Ephedrine 256 Epicondyles, lateral and medial 20 Epidemiology 371 Epidermis 69 Epidermophyton.. 418 Epididymis 70,490 Epididymitis 498,501 Epigastric (solar) plexus 79 Epiglottis.. 48 Epilepsy 123 Epimysium 24 Epinephrine (adrenalin). 63 Epinephrine (adrenalin) hydrochloride 247 Epiphysis. (See Pineal body.) Epispastics... 318 Epistaxis (nosebleed) — 90 Epithelial tissue (epithelium) 11 Classes of 11 Epso m salt. 198 Equations 673 Balancing of. '.... 674 Chemical. 673,674 Oxidation and reduction, balancing of...... 697 Equipment; Page For— Postmortem examinations 841 Postmortem specimens 843 Shore patrol 574 Ledger. 776,777 Of operating room. 357 X-ray: Arrangement of 954 Shock-proof 954 Erepsin. 60 Ergosterol, solution of irradiated 237, 582 Ergot, fluidextract of 255 Eruption-s 276 Erysipelas 341 Erythroblasts 15 Erythrocytes 33 Escharotics (caustics) 178,319 Eserine sulfate (physostigmine sulfate) 253 Esters: Definition of 720 Of organic acids 720 Ethane 717 Ether-s 221,719,739,740 Anaesthesia, induction of 737 Bed.. 292 Definition of 719 Solvent (ethyl oxide) 222 “Sulfuric” 7I9 Ethyl: Acetate 720 Alcohol 218,718 Chloride 217,718,739,740 Ether l 222,739,740 Nitrite, spirit of 229,720 Ethylene-s 721,739,740 EucalyptoL. 231 Eugenol. 231 Eustachian (auditory) tubes 52,82 Evaporation 616 Of body heat.. 445 Eversion. * 23,114 Of eyelid 119 Evipal soluble (sodium cyclural) 745 Examination-s: Darkfield. 903 Of— Patients 355 Urine 890 Sediment in 891 Water. 440 Physical 848 Postmortem 840 X-ray. _ 103,954 Excitants, cerebral 178 Excretions 63 Excretory organs 63 Alimentary canal. 64 Ldngs 63 Skin. 63 Urinary system 63 Exercise. 304,919 Of patients 304 Types of... 919 Expectorants 178 Expense analysis register 777 INDEX 985 Page Expression 622 Exsiccation 616 Extension 24 In treatment of— Dislocation of shoulder 104 Fracture 107 External: Auditory canal 16,82 Ear 22 Inguinal ring 27 Oblique muscle 26 Extract-s (extracta) 629 Of— Belladonna 251 Cascara sagrada 245 Liver 247 Extraction 622 Eye: Application of ointment to 331 Balls 81 Brows 81 Chambers of 82 Douche 330 Installation of drops 331 Lashes 81 Lids. 81 Nursing in conditions of 330 Operations on 332 Removal of foreign bodies from (jl8, 331 Strain, cause of 435 Treatment of wounds of 100 Face, bones of 17 Faeces 61,277 Observation of 277 Significance of color of 277 Fahrenheit scale 614 Faradic current 930 Surging 930 Fasciae 24 Fasciculus 24 Fasciolopsis buski (intestinal fluke) 909 Fats 580,720 Sources of 580 Fauces, anterior pillars of 62 Febrifuges 179 Feeding, special methods of 593 Feet, care of 562 Femoral: Artery —— 43 Nerve - 78 Ring 27 Vein 44 Femur 21 Fracture of - 112 Splinting of fractured 113 Fenestra ovalis.. 83 Ferments, digestive. (See Enzymes.) Ferric: Chloride, tincture of 204,712 Citrochloride, tincture of 205 Hydroxide, magma of.. 205,263 Ferrous: Carbonate, pills of (Blaud’s pills). 205 Chloride 712 Fertilization 9 Pago Fever-s._ 83,128, 280 Continuous 280 Diet in 592 Intermittent 280 Remittent 280 Termination of (crisis; lysis) 280 Treatment of 128 Fiber-s: Muscle 13,24 Nerve 72,73 Fibrin 33 Fibrinogen 30,33 Field: Conservancy 533 Sanitation. in, vx, 521 Filing: Manual, U. S. Navy 772 System, U. S. Navy 772 Film-s: Exposures 955 X-ray. 958 Filters 441 Field... 533 Pressure 441 Rapid, mechanical, gravity, sand 441 Slow sand 441 Sprinkling 441 Filtrable virus 373,901 Filtration 621 Beds, intermittent sand 441 Water . 441 Filum terminate 77 Finger-s: Bones of 19 Fracture of 112 Joints, dislocation of.. 103 Prints, in identifying dead 840 First aid 85,849 At a fire 117 Dental 171 Dressing of wounds 95 General measures in 85 Minor surgery and ni, v, 85 Packet 95 First-aid treatment of; Abdomen, acute conditions of - 126 Abscess 87 Apoplexy 124 Appendicitis, acute 126 Asphyxia 120 Aviation... 849 Boil or furuncle 87 Bright’s disease - 125 Bruise— 101 Bums and scalds 116 Carbuncle 87 Chills 1 - 130 Cold 114,117,129 Compression of brain 124 Concussion of brain 124 Contusion 101 Convulsions 130 Diarrhoea 129 Dislocation. 102 Earache.,.,, - 13° 986 INDEX First-aid treatment of—Continued. Page Epilepsy or fits 123 Fractures 105 Gall-stone colic. 127 Gastric or duodenal ulcer, perforated... 127 Haemorrhage 89 Headache ... 129 Heat exhaustion... 114 Heat stroke 114 Hiccough 130 Hysterical unconsciousness 124 Inflammation 86,128 Intestinal obstruction, acute 127 Kidney-stone colic 128 Poisoning causing acute abdominal symp- toms 128 Poisonous insect bites 98 Removal of foreign bodies 118 Scalds... — 116 Shock. '88 Electric 88,123 Snake bites. 100 Sore throat 130 Sprain. 101 Strain 101 Unconsciousness 122 Caused by alcoholism 125 Uraemia 125 Wounds... 93 Fish, as food 689,813 Fission... 9,901 Fissure-s 16 Of— Cerebrum 74 Liver 56 Sphenoidal 81 Fitzsimons General Hospital 758 “Five Rights” in administration of medi- cines 304 Fixed oils, fats, and soaps 236 Flagellata (mastigophora) 907 Trypansoma gambiense 907 Flavors in foods. 579 Fleas (siphonaptera)... 449, 551 Control measures for. 449,551 Fleet Marine Force 566 Flexion 24 Flexure: Hepatic 55 Sigmoid 55 Splenic 55 Ventro-median 77 Flies .... 447,916 Control measures for. 448,543 Development (metamorphosis) of. 447 Glossina palpalis (tsetse) 916 Musca domestica (house or “typhoid”)... 447,916 Sarcophaga carnaria (flesh) 916 Stomoxys calcitrans (stable) 916 Fluid: Cerebrospinal 75,77 Embalming, formula for 886 Pericardial ... 36 Peritoneal 53 Seminal 70 Serous 28 Fluid—Continued. Page Specimens, collection of. 288 Synovial . 28 Tissue 8 Fluidextract-s (fluidextracta) 245,626 Of— Caseara sagrada, aromatic 245 Ergot 255 Ginger 232 Hyoscyamus 252 Ipecac ... 254 Licorice 243 Rhubarb.. 245 IJ. 8. P. processes for making 626 Fluidity, definition of 654 Flukes. (See Trematodes.) Fluorine 689,691 Fomentations, hot 316,331 Fomites 372 Food-s —. 57,523,579 Acid forming 586 Adulteration 814 Allergy. 477 And its relation to health and disease 377 Animal.. 588 Bacon 589 ' Beef. 588,825 Beverages. 586 Bolus 59 O alcium in 680 Canning of. ' 817 Carbohydrates .... 57,579 Cereals.. 589 Chemical preservatives 817 C lassification of 579 Cold, preservation by 816 Colors of 819 C ondiments 679,586 Containing alkalies 586 Copper in 581 Deficiency diseases 818 Drying 816 Eggs 589,811 Energy value of 583 Fats.. * ..i... 57,579 Fish.—.1. . 589,813 Flavors 579,586 Fruits. 590 Green vegetables :... 590 Ham 589 Importance of in care of patient 301 Infection 377 Inorganic mineral salts in 57,580 Inspection 382,810 Intoxication 379 Iodine in 581 Iron in 581 Lamb ... 588 Legumes 689 Meat 588,810 Military ration 523 Milk 382,813 Mutton 588 Nuts 690 On the march. — 558 Phosphorus in 580 INDEX 987 Food-s—Continued. , Page Pickling 817 Poisoning: Acute symptoms of.. 265,377 Pork.... 588,832 Poultry 589,811,833 Preservation... 626,816 Proteins 57,579 Requirements of individuals 523,585,818 Roots and tubers 589 Serving of 301 Shellfish 814 Smoking 817 Toxins.. 377 Values in calories, tables of.. 586 Veal... — 588 Vegetables 589 Viscera, animal 689 Vitamins 57,579 Water 57,579 Foot: Anatomy and physiology of 561 Baths... 312 Care of 562 Fracture of 114 Powder, formula for 564 Foramen-ina 16 Intervertebral. 78 Magnum 16,74 Obturator 21 Optic 81 Ovale 37 Papillaria. 66 Vertebral... 19 Foraminae, nutrient — 15 Force, definition of. 654 Force surgeon, Marine Corps expeditionary force 566 Forearm: Bones of 20 Fracture of Ill Foreign bodies, removal of 118,119,120,331 Foreword in, v Formaldehyde 364,817 Gas.. 453 Solution of 220 Formalin 220 Disinfectant.. 451 Form-s; Blank 773 NMS B; report of allotment expenditures and obligations.. 778,798 E; statement of receipts and expendi- tures of medical department prop- erty 778,796 F card; individual statistical report of patient. 458 N; death certificate 458 Q; clinical chart 284 R; issue voucher 777,784 W; supplies and equipment ledger sheet.. 777 4; medical supplies and equipment requisition and invoice 777 Forms—Continued. Page NMS B; report—Continued. 37; receipt and expenditure voucher (for commissary ledger) . 815 Aviation No. 1; physical examination for flying 848 Aviation No. 3; report of crash _ 848 NMSH 17; clinical notes 285 23; order and inspection blank 809 36; quarterly ration return 777 59; clinical record... 285 Bill of fare for general mess, etc. (S&A Form 333) 818 Property survey (S&A Form 154) 784 Summary of stub requisitions (S&A Form 178). 789 Formula-s; Chemical. 662 Empirical. 662 Graphic or structural 662 Of radicals 680 Rational 662 Stereochemic., 662 For— Compound solution of tannic acid-. 228 Corn collodion.. 564 Corn salve 564 Embalming fluid ., 886 Foot powder 564 Navy prophylactic tube... 513 Surgical lubricant 240 Tannic-acid jelly 228 Formulary, National, description of 601 Fossa-se 16 Anterior cranial 16 Middle cranial. 16 Posterior cranial 16 Temporal "... 16 Fowler’s: Position 326 Solution.. 206 Fracture-s - 105 Bed. - 292 Callus in 105,106 Crepitus in 106 Definition of 105 Diagnosis of... , 106 X-ray 108 Of certain bones, symptoms and treatment of 108 Reduction or setting of. — 107 Simple, general principles for treatment of.. 106 Splints for 107 Symptoms of. , 105 Types of 105 Friction.. 613,656 Frontal: Bone,. I7 Lobe of cerebrum. 75 Sinuses 17 Frostbite H8 Fruits as food 590 Fumigation 373,450 Carboxide gas... — 452 Distinction from disinfection 450 154294°—39 63 988 INDEX Fumigation—Continued. Page Formaldehyde gas 453 Gaseous agents used in 462 Hydrocyanic acid gas... 462 Sulfur dioxide 452 Fund, Naval Hospital... 779 Fur, used for clothing 446 Furuncle 87 Fuses.. 950 Fusion 616 Galenical preparations 624 Gall bladder 56 Gall-stone colic 127 Galvanic current 929 Interrupted 930 Ganglia 72 Garbage. (See Refuse.) Gas-es: Lacrimatory — 863 Law of compressibility of. 655 La w of expansion of 656 Law of solubility of. 659 Mustard 868 Vesicant (chemical warfare) 868 Gas gangrene.. 95 Gaseous: Agents used in fumigation— Carboxide gas 452 Formaldehyde gas 463 Hydrocyanic-acid gas.. 452 Sulfur dioxide 452 Content of atmosphere 428,692 Poisons 258,260 State of matter 653 Gasoline, poisoning by 269 Gastric: Analysis — 897 Gavage.. 321 Glands 59 Juice 59 Lavage 321 Ulcer, diet in.. 591 Gastro-pulmonary mucous membrane ‘ 8 Gavage, definition of 322 General; Anaesthesia. (See Anaesthesia.) Heat radiation 429 Ledger 776 Genital organs, male 69 Genitourinary: And venereal diseases. in, v, 490 Doses, dangers and strengths of solutions used in 607 Mucous membrane 28 System 490 Gentian violet: As disinfectant 364 Solution, Stirling’s 902 German measles 337,386 Oingiva-ae (gum-s) 169 Glacial acetic acid 226 Gland-s 29 Compound 29 Ductless (endocrine) 29,61 Salivary 52 Simple 29 Qians penis 70 Page Qlomerulus-i . 66 Glottis 47 Glucose. 241 Qlueoside-s 243 Olucosidal drags, and preparations made from 243 Glycerin 219 Use of in iodine and tannic-acid ointments.. 634 Qlycerites (glycerita) 627 Glycogen 61 Olyeyrrhiza 243 Goiter . 62 Gold 712 Gonads 63 Ovaries. 63 Testes 63,69 Gonorrhoea, symptoms and treatment of... 414,496 Gonorrhoeal; Ophthalmia... 332,502 Smears, collection of and precautions in taking 288 Grain weight 602 Gram weight 603 Gram-molecular volume... 663 Gram-molecular weight 663 Gram’s stain.. 902 Granulation 616 Granulocytes 36 Gray matter 74 Green iron and ammonium citrates. 205 Groove 16 Dorso-median... 77 Grouping, blood, and matching m, vi, 856 Quaiacol 225 Gum: Arabic 240 Resins 234 Gumboils 173 Gunshot wound-s 100 Haematology.. 905 Haemoglobin. 35,49,906 Reduced 49 Haemolysin-s. 35,99 Haemolysis 35 Haemophilia : 33 Haemophiliac. 33,90 Haemophilus: Ducreyii (Bacillus of chancroid) 414,496 Influenzae (Bacillus influenzae) 341 Pertussis (Bacillus of Bordet-Gengou) 397 Haemoptysis. 93 Haemorrhage 89 Arterial - 89 Prom- Arm, forearm, or hand 92 Armpit 92 Face 92 Lips 92 Lungs 93 Neck 92 Stomach 93 Thigh, leg, or toot 93 Capillary 89 Consecutive or intermediate. 93 Constitutional treatment of 92 From scalp 92 INDEX 989 Haemorrhage—Continued. Page I Internal 93 Ligation 90 Primary. 93 Secondary 93 Tourniquet, use of in 91 Treatment of.. 90 ; Venous 89 Haemorrhagin 99 Haemosporidia.. 908 Plasmodium falciparum; malariae, and vivas... 339,908 Haemostatics 179 Halibut liver oil and viosterol 237 Halogen-s (chlorine family of elements) 689 Substitution products 718 Ham and bacon 588 Hard soap 238 Hardness; Definition of 654 Of water 440 Harrison Narcotic Law 637 Haversian canals 15 Hay fever 470 Hazards: Industrial 514 Occupational.. 515 Headache 129 : Healing of wounds— 94 : First intention 94 : Second intention 94 ; Health records, care of— 889 ; Hearing: Center of 83 ; End organ of 83 Organ of... 82 . Sense of - 80 Heart: Action of 37 Blood supply of 37 Description of 36 Nerve supply of 37 Sounds 38 Valves of 37 Heat 613,656 And cold, application of 311 Conduction of. 429 Convection of — 429 Cramps 114 Dry 315 Sterilization by 362 Evaporation of body 445 Exhaustion. 114 Methods of measuring 656 Moist 315 Of combustion 694 Pharmaceutical processes requiring use of... 615 Radiation of—. 429 Regulating center. 429 Regulation 83 Sterilization by (thermal) 362 Stroke. 114,556 Heating: Direct 433 Direct-indirect 433 Indirect. 433 I Heating—Continued. Page Of— Compartments and rooms 433 Operating room 353 Heliotherapy 923 Henry’s law 659 Heparin ... 33 Hepatic: Duct 56 Stimulants- . 179 Vein 45 Heroin (prohibitions against) 636 Poisoning by 266 Herpes 296,504 Hexamethylenetetramine- 220 Hiccough-s (singultus) 130,283 How described 276 High frequency (electric current) 931 Diathermy apparatus 931 MonoterminaL. 932 Saturation 932 High tension leads to X-ray tubes 965 Hilum of— Kidney 65 Lung 48 Hints in practical pharmacy 638 Histology. 7 History of the Hospital Corps m, 1 Homatropine hydrohromide 252 Homologous series 716 Homologue.- 716 Homology 716 Hookworm disease (ancylostomiasis) 403 Hookworms. (See Ancylostoma duodenale and Necator americanus.) Hormone-s 61,891 Transmission of 32 Hospital-s: Corps- History of the. ..... nr, 1 Schools 763 Fund, Naval — 779 Naval. - ..I.. 757 Other than navy 758 Supplies and property accountability.— in, vi, 774 Hosts (animal parasitology) 907 Hot: Applications 331 Baths 311 Fomentations (stupes) 331 Packs 311,920 Quartz lamps- 926 Water bags.. 316 Housing of personnel 435 Humerus. — 20 Fracture of. — 111 Humidity 430 Relative - 430 Hyaloid membrane 82 Hydriodic acid - 691 Hydrobromic acid 690 Hydrocarbon-s —- 215 And their derivatives, chemistry of. 713 Aromatic,. ' 722 Derivatives - 718 990 INDEX Hydrocarbon-s— Continued. Page Hydrogen derivatives of 216 Unsaturated— 721 Hydrochloric acid 60,185,690 In gastric juice 60 Poisoning by 266 Hydrocyanic-acid 265 Gas. 265,452 Poisoning by 266 Hydrofluoric acid 692,817 Hydrogen 649,686,874 Acids 681 Derivatives of hydrocarbons 216 Dioxide (peroxide) 96,173, 351 Ion concentration and Indicators 729 Ion scale 730 Sulfide 699 Hydrogogues 178 Hydrokinetic measures...... 922 Hydrolysis- 241 Hydrolytic agents 241 Hydrophobia (rabies) 95 Hydrotherapy 920 Hydroxide-s 685 H ydroxyl radical 680 Hygiene: And sanitation. in, v, 371 Of the march.. 552 Personal.. 455 Hygroscopic 622 Hymenolepis nana (dwarf tapeworm) ._ 910 Hyoscyamus. 252,265 Fluidextract of. 252 Poisoning by. 266 Hypermetropia.. 82 Hyperpyrexia 935 Hypersensitiveness 376,486 Tests for.. 474 Hypertherm (Kettering) 935 Hypnotics 179 Hypodermic: Injection, method of giving 308 Tray. 308 Hypodermoclysis 309 Hypogastric plexus 79 Hypophysis. (See Pituitary body.) Hysterical unconsciousness 124 latro-chemistry. 645 Ice caps (bags) 349 Ichthammol— 216 Identification: Of dead 840 Records. 840 Tags 840 Idiosyncrasy 258,180 Food (allergy) ......... 377,477 Ignition 616 Heocseeal: Orifice. 54 Valve. 54 Ileum.. ...1 54 Ilium.. .... — 21 Immune reaction in vaccination 425 Page Immunity 32,373 Acquired .. 375 Active.. 375 Passive . 375 Inherent 375 Mass.. 376 Serums, use of in 375,434 Incineration 540,616 Ineinerator-s: Closed type 540 In field. 540 Open type. 540 Incompatibility.. 636 Chemical 1 636 Pharmaceutical. 636 Therapeutic 636 Incubation period, definition of 373 Independent duty ni, vi, 887 Indestructibility of matter, law of 653 Indicators: Definition of 730 Table of 731 Induction 946 Inductotherm 935 Industrial medicine and industrial hazards., in, Vi, 514 Inert gases 692 Infection 95,360 Bacteria causing 94 Food 377 In wounds.. 94,36! Prevention of. 36I Infectious organisms 95 Infiltration and block anaesthesia 735,736 Inflammation ge, 128,360 Causes of 86 Treatment of... 86 Influenza 341,337 Infrared rays 924 Infusion, saline 594 Infusions (infusa)„ 623 Infusoria 627,908 Balantidium eoli 908 Inguinal: Ligament (Poupart’s) 27 Ring- External 27 Internal...... 27 Inhalation: Administration of drugs by 307 Anaesthesia 737 Initial lesion, syphilis 493 Injuries 114 Innominate: Artery 40 Bone 21 Vein.. — 44 Inorganic: Acids (mineral) 185 Chemistry 659 Materia medica 181 Matter : 5,643 Salts (mineral) 580 INDEX 991 Page Page Insalivation 51 Insane, care of 836 Insecta.. 913 Bedbugs. 650 Cockroaches 551 Fleas (siphonaptera)— 551,916 Flies 447,543,916 Lice (pediculidae) 550,916 Mosquitoes (culieidae)... 446,547,914 Insect-s: Bites 98 Control of, in camps 446,643 Diseases transmitted by. 407 Repellent, formula for 648 Insecticide spray, formula for 548 Insensibility. (See Unconsciousness.) Insolation. (See Heatstroke.) Inspection: Food 382,810 General, of wards 350 Of— Equipment for landing forces 573 Food handlers.. 378,525 Personnel on march 560 Sanitary. 559, 565, 576,887 Instruments, surgical: Basic outfit for ordinary operations 367 Care of 367 Instrumentation: In genitourinary and venereal diseases 504 Of urinary system. 504 Insulin 63,247 Intensifying screens 961 Intercellular substance 11 Intermittent sand filtration beds.... 444 Internal: Ear.. 82 Haemorrhage. 93 Inguinal ring 27 Oblique muscle. 26 Secretion, glands of 61 International: Classification of blood groups 856 Digitalis unit 244 List of causes of death 465 Interpretation of vital statistics. 467 Interstitial water 622 Intervertebral foramen 78 Intestinal: Juice 54,60 Obstruction, acute 127 Suture, atraumatic 366 Intestine 54 Large 54 Small 54 Glands of. 54 Intoxication, food 379 Intramuscular administration of drugs 181,309 Intravascular medication 1 309,594 Blood transfusion 856 Intravenous: Administration of drugs 181,309 Anaesthesia 745 Inunction-*.. 181 Nutrient 594 Inversion,. 24 Invertase.. 58,69 lodimetry 732 Iodine J 182, 265,318, 363,581,689 Amount required in diet 581 And its preparations 182 As rubefacient 318 Compound solution of (Lugol’s) 183 Goiter caused by lack of 183 Mild tincture of 182 Poisoning by... 182,266 Solution, Gram’s 902 Tincture of. 96,182 Iodoform (triiodomethane) 217 Ionic medication 929 Ionization 670,726 Ions 670 Ipecac 254 And opium, powdered 249 Fluidextract of 254 Iris 82 Iron 581,711 Amount required in diet 681 Anaemia caused by lack of 681 Compounds 204 Group of elements 711 Tasteless tincture of 205 Tincture of 204 Irradiation: General: Clinical uses of. 925 Technique of 927 Local. 925,927 Irrigation-s: Aural 333 Bladder. 327 Nasal. .... 334 Of wounds 330,362 Saline 594 Irritant-s - 179 Counter 315 Gases, poisoning by 266 Lung (chemicalwarfare) 866 Smokes (chemical warfare) 863 Ischium 21 Island-s: Of— Langerhans. 57 Reil 75 Isolation 694 Isomers 716 Isomerism 716 Isotonic 193 Isotopes 651 Jansky classification of blood groups 856 Jaw-s; Bones of (mandible; maxillae) 18 Fracture of lower 108,175 Jejunum 64 Jelly, tannic-acid, formulas for 228 Joint-s, description of 22 Ball and socket ... 22 Condyloid. 24 Gliding 22 992 INDEX Joints—Continued. Hinge.. 22 Immovable 22 Movable 22 Movements 24 Rotary 22 I Journal 776 Of receipts and expenditures. 777,793 Judge Advocate General of the Navy 750 Earelldiet 591 Katabolism.. 9 Katathermometer 873 Ketone-s 719 Kidney-s. 65 Functions of 66 Functional tests 893 Stone colic 128 Kilogram, weight 603 Kindling temperature 693 Kinetic: Energy 654 Theory 657 Klebsiella pneumonise (Friedlander’s ba- cillus)... 341 Knee (hinge joint)... 22 Cap, fracture of.. 113 Dislocation of 104 Kocher’s method for reduction of shoulder dislocation 104 Laboratory procedures and technique in, Vi, 889 Labyrinth, bony, of internal ear 83 Lacrimal: Apparatus. 81 Bones.. 18 Glands 81 Sac — 81 Lacrimatory gases (chemical warfare) 863 Lactase 58,59 Lacteals. - 54 Lactrodeetus mactans (“black widow” spider) — 913 Lamb, as food 588 Cuts of 830 Lamps: Electrodeless high frequency induction 927 Quartz mercury-vapor 926 Land and buildings ledger 776 Landing force in, vi, 570 Organization and equipment 570 Sanitary problems in ... 573 Landsteiner classification of blood groups 856 Lanolin 238 Lard — — 238 Benzoinated 238 Larva-se 548,914 Asiphonate 914 Siphonate 914 Larvacide-s 649 Larynx (organ of voice) 47 Latin words used in pharmacy, table of 635 Latrine-s; Care of ' 637 Frontage 637 Location 537 Types of 535 Page Lavage, gastric.. 322 Laws and theories 652 Avogadro’s. 656 Boyle’s . 655 Charles’.. 656 Compressibility of gases 655 Conservation of energy 655 Conservation of matter 654 Constant proportions 652 Dalton’s 652 Expansion of gases 656 Henry’s. 659 Indestructibility of matter 653 Multiple proportions ...... 652 Reciprocal proportions .... 652 Solubility of gases 659 Laxatives 178 Lead 265,711 Acetate.. 209 Carbonate, basic. 711 Compounds of.. 209 Oxides 711 Poisoning by.. 266 Leather, used for clothing 446 Ledger; Commissary 777,815 Equipment.. 777 General 776 Land and buildings 776 Supplies 776 Leg, fracture of 113 Legumes, as food 589 Lenhartz diet 591 Lens, crystalline 82 Lepers, quarantine of 454 Letters, official, forms of 765 Leucocytes 35 Migration of 35 Schilling classification of 906 Leucocy tosis 35,86,905 Leucomaines 248 Leueopenia 35,905 Levigation (porphyization) 617 Levulose 241 Lewisite . 870 Lice (pediculidse) 449,550 Control measures for 449 Licorice 243 Ligament=s 22 Inguinal (Poupart’s) 27 Joint 22 Ligation, in haemorrhage 97 Ligatures 97,365 Light-ing: Artificial 433 Direct 434 Indirect- 434 Chemical effects of.. 434 Eyestrain caused by improper 435 Illuminants. 433 Illumination 434 Measuring, and instruments for 435 Natural 434 Source of 434 Standard for 435 Page INDEX 993 Page Page Light-ing—C ontinued. Of— Operating room 356 Wards, and rooms. 352 Therapeutic effects of 434 Therapy.. 924 Clinical uses. 924 Precautions in 924 Sources 924 Technique of 925 Lime; chlorinated 199 Disinfectant 451 Linen: Care of 350 Exchange of 350 Removal of stains from. 351 Used for clothing 446 Ward 350 Liniment-s (linimenta) 627 Soap 239 Lipase 60 Liquefied phenol 223 Liquid-s: Diet 593 Immiscible 659 Measure.. 606 Miscible 659 Petrolatum 215 Preparations.... 624 Solubility of 659 State of matter 653 Supernatant 621 Liquor, mother 622 Liter, measure... 603 Lithium 55,708 Liver ... 55 Functionsof 56 Lobes of 56 Lividity, cadaveric (suggillation) 837,838 Long Island College Hospital diet.. 591 Lotion 620 Lower: Extremity, bones of.. . 21 Jaw, fracture of 108,175 Lubricant, surgical, formula for 240 Lumbosacral plexus. 78 Lumbricus 71 Lung-s.. 48 Aircapacityof. 51 Haemorrhage from (haemoptysis) 93 Irritants (chemical warfare) 866 Lobes of 48 Lymph 30,45 Glands 46 Nodes 46 Vascular system... 45 Vessels 46 Lymphatic duct 46 Lymphocytes 36 Lymphogranuloma venereum (inguinale) 415 Lysis 280 Maceration 622 And expression. 622 Circulatory — 623 Maggot traps.. 542 Magma-s (magmse 621,627 Of— Ferric hydroxide (arsenic antidote) 205,263 Magnesia.. 199 Magnesium 708 Carbonate 198 Chloride 708 Citrate, solution of 198 Compounds 198 Oxide (in glacial acetic acid poisoning) 226 Heavy 199 Antidote for corrosive-acid poisoning. _. 226 Sulfate 198,708 Major General Commandant, U. S. Marine Corps . 750, 754 Malaria 339,408 Benign tertian 408 Malignant tertain 408 Quartan 408 Malleability, definition of 654 Malleolus, internal and lateral 22 Malpighian bodies (renal corpuscles) 66 Maltese 59 Mammalia 6 Management, ward in, v, 344 Manubrium 1 „ 19 Mapharsen . 505 March sanitation.. 559 Marine Corps Expeditionary Forces, duty with. m, vi, 564 Maritime quarantine 454 Marrow, bone 15 Giant cells of (megakaryocytes) 36 March-gas series 717 Mass 654 Immunity. 376 Massage.. 917 Masses (mass®) 630 Mastication 51,59 Mastoid process 16,17 Materia medica: And therapeutics... in, v, 177 Definition of 177, 599 Inorganic 181 Organic — 215 Matter ... 653 Characteristics of 653 Law of conservation of 654 Law of indestructibility of 653 Inorganic 5,643 Organic 5,643 Physical phenomena of 653 Propertiesof. 653 Mattress-es: Care of.. 289 Changing of... 291 Covers 289 Turning of 292 Maxillary sinus 18 Measles 337,388 994 INDEX Measure-s 606 Liquid 606 Pharmaceutical 606 Tables of.. 604 Meat cutting 825 Meatus, urinary. 71 Mechanotherapy 917 Media, culture 899 Mediastinal: Arteries 41 Pleura. 49 Septum 48 Medical: Company, Marine Corps expeditionary force... 565 C ollect ingsection.. 565 Headquarters section 564 Hospital section 564 Service section 565 Corps. 752 Department—.. 752 Allotments 780 Appropriations.. 780 Clerical work 763 Of— Marine Corps expeditionary force 565 Marine Corps post 565 Ship’s landing force... 571 On the march 560 Personnel- 671,759 Supplies, procurement of 779 Detachment of shore patrol. 574 Section, Marine Corps expeditionary force.. 666 Battalion 566 Regimental ,... 566 Supply depots 763 Troops, Marine Corps expeditionary force.. 566 Medicated baths 314 Medication, ionic. 929 Medicine-s: Administration of 181,304 Methods of.. . 181.304 And Surgery, bureau of 752 Aviation in, vi, 847 Bottles. 306 Labels 306 Industrial, and industrial hazards m, vi, 514 Locker, care of 305 Tickets 306 Trays.... 306 Medicolegal matters, deaths and m, vi, 833 Medulla: Oblongata (spinal bulb) 76 Of— Kidney 65 Suprarenal glands 62 Spinalis (spinal cord) 72,77 Medullary: Canal. 14 Sheath 73 Substance of kidney 65 Meibomian glands 81 Membrane-s 28 Cutaneous 29 Hyaloid. 82 Mucous. 28 Peridental- 169 Page Membrane-s—Continued. Plasma... 8 Serous 28 Special, and glands in general. 28 Synovial 22,28 Tympanic (ear drum) 82 Meninges 74 Arachnoid coat of... 28,74 Meningitis (cerebrospinal fever) 342 Meningococcus 342,383 Meniscus.. 606,658 Menstruum 622 Menthol 230 Menu-s: Adequate diet 817 And their preparation 818 Forms used for. 818 Regular diet 818 Sample, naval hospital 820 Table of foods found on 824 Mercurial ointment; Mild (blueointment) 212 Strong 212 Mercuric 211 Chloride 211,710 Oxide, yellow.. 211 Oxycyanide 212 Salicylate. 211 Mercurochrome soluble 212,364 Mercurous chloride, mild. 210,710 Mercury (quicksilver) 209,710 Ammoniated 210 Bichloride. 210, 264, 266, 363,451 Large poison tablets of 211 Small poison tablets of 211 Citrine ointment 633 Compounds 209 Poisoning by 266 Vapor lamps, quartz 926 Yellow oxide of 211 Merozoites 909 Merthiolate 213 Mesentery 53 Mess-es: Attendants, naval hospitals 806 General, naval hospitals 806 Hall-s 525,806 Police petty officer, duties of 806 Nurses’ 806 Sick officers’ 806 Metabolism... 6, 46 Basal in, vi, 849 Destructive (katabolism) 9 Metacarpal bones 21 Fracture of i 112 M etallic oxides 693 Metals 706 Alkali. 706 Alkaline earth 708 Iron group of 711 Tin group of 710 Metamorphosis (development): Of— Flies 447 M alarial parasites 909 Mosquitoes 447 Metathesis (double decomposition) 674 Metazoon 71 Page INDEX 995 Page Meter, measure 602,603 Methane 718 Series. 717 Methenamine (urotropin) 221 Methyl: Alcohol 219 Poisoning by 264 Radical. 680 Salicylate 232 Metric system of weights and measures 602 Metrology, definition of 602 Metycaine hydrochloride _. . 736,737 Micrometry.. .. 899 Micron (micromillimeter) 603,899 Microscope, care of .. 899 Microscopy .. 599 Micturition 68 Expedients to cause voluntary 327 Middle ear 82 Migraine ... 480 Mild mercurial ointment. ... ... 212 Milk, as food 382, 589,813 Pasteurization of 382 Peptonized 594 Sterilization of 589 Milligram, weight 603 Milliliter, measure . 603 Mineral acids 683 Poisoning by 267 Mineral oil 215 Mineralogy I 599 Minim, measure .. 606 Minor surgery _. 85 And first aid _ in, v, 85 Mites . 913 Mitosis (mitotic division) ... . 9 Mitral valve 37 Mixtures (mistura) _.. 627 Modes of transmission of infectious diseases... 372 Molar: Solutions ;. 727 Teeth 52 Volume 663 Mole (gram-molecular weight) 663, 727 Molecular: Physics .. .. 657 Weight 663 Molecules, definition of . . 646 Monobasic acids 683 Monocytes 36 Monohydric bases. 685 Monosaccharides. 721 Monoterminal high-frequency (electric cur- rent) 932 Morgue, care of 841 Morphine; Poisoning by 267 Sulfate 250,747 Mosquito-es , 446,547 Aedes aegypti... 340,407,412,446,914,915 Anopheles 446,914,915 Control in camp 447 Oulex 446,914,915 Development (metamorphosis) of 447 Page Moss classification of blood groups 856 Motor: Cells (effector) 71 Depressants. 179 Excitants 179 Nerves 72 Mountain sickness 431 Mouth _. 47,51,296 And teeth, care of... 296 Mueilagines (mucilages)... 628 Mucous membrane 28 Multiple proportions, law of 652 Mummification ■ 837 Mumps 390 Murphy drip (proctoclysis). 310 Muscle-s 13,24 Action of. .. 24 Adductor , .... 24 As anatomical landmarks 27 Biceps 28 Deltoid.. 28 Diaphragm.. 26,28 Epimysium of 24 Extensor 24 Fasciae of 24 Fasciculus of ,.. 24 Fibers 13,24 Inguinal (Poupart's) ligament . 27 Insertion of 24 Internal oblique 26 Oblique of eye 81 Of— Abdomen 26 Back 26 Chest and thorax 26 Head and face 26 Lower extremity 27 Neck... 26 Perineum...... 27 Upper extremity 27 Origin of 24 Perimysium of ... 24 Recti, of eye 81 Rectus abdominis 26 Sarcolemma of ... 24 Skeletal 24 Sternocleidomastoid 27 Temporal 27 Transversus abdominis 26 Triceps 28 Muscular tissue 11,13 Cells of. 13 Changes in substance of 26 Properties of 13 Rigor mortis 26 Types of— Cardiac - 13 Nonstriated. .. 13 Striated * 13 Mustard: Gas ... 868 Sinapisms (plasters) 233 Mutton. 588 Mutualism 907 996 INDEX Page Mycobacterium tuberculosis (Bacillus tuber- culosis) : Hominis (human) 342,361,395 Hominis et bovis (human and bovine)...... 396 Mydriatics 179 Myocardium . 37 Myology 7,24 Myopia 82 Myotics. 179 Naphtha, poisoning by 269 Narcotic-s 179 Law, Harrison 637 Nasal; Apertures, posterior 16 Bones 18 Chambers 47 Duct.. 81 Irrigations 334 Septum. 47 National Formulary, description of 601 Natural: Oleoresins 234 Ventilation.. 432 Naval: Bases. 754 Dispensary 763 F orces and stations. 754 Hospital Fund 779 Hospitals.. 757,760 Medical: Center.. 763 School 752 Supply depots. 763 Operating bases 755 Operations, office of 751 Policy 755 Stations ... 754 Strategy 755 Tactics 755 Navigation, Bureau of.. 751 Navy: Department... 749 Uniform 446 Yards.. 755 Necator americanus (hookworm) 403,911 Neck: Bones of — 18 Muscles of 25 Of bones ..... 16 Needles.. 97 Neisseria: Gonorrhoea? (Gonococcus) 414,497 Intracellularis (Diplocoecus intracellularis meningitidis; meningococcus) 342,383 Nemathelminthes (round worms) 911 Ascaris lumbricoides , 911 Enterobius vermicularis 912 Hookworms 911 Trichinella spiralis. 912 Trichuris trichiura 912 W ucheria bancrofti 912 Neoarsphenamine 206,505 Nerve-s.. 72 Action... 79 Afferent (sensory) 72,73 Nerve-s—Continued. Page Cells (neurones) _ 72,73 Connector . 71 Cyton (body) of 73 Effector (motor) _ 71 Motor,.. 71 Multipolar 73 Processes. 71 Axone (or axis cylinder). . 73 Central. 71 Dendrone (dendrite or protoplasmic)... 73 Peripheral 71 Unipolar 73 Centers (ganglia) : 72 Chorda tympani . 83 Cord 71 Cranial (cerebral). 72,78 Efferent (motor) 72,73 Endings (receptors) 79 Femoral. 78 Fibers 72,73 Conductivity 79 Gray 73 Medullated (white) 73 Medullary sheath (white substance of Sehwamm) 73 N eurolemm a 73 Nonmedullated (gray) 73 Primitive sheath (neurolemma) 73 White 73 Ganglia. 72 Cerebral ’ 72 Glossopharyngeal 83 Impressions. 72, 79 Impulses 72,79 Inhibitory. I 74 Intercostal 50 Lingual 83 Median. 78 Mixed 72 Motor (efferent) 72 Obturator... 78 Phrenic 50 Pneumogastric 37 Radial 78 Sciatic 78 Secretory..., 74 Sensory (afferent) : 72 Spinal 72-78 Roots of 78 Tissue 72 Trunks 72,73 Ulnar 78 Vagus 50 Nervous: System-s 71 Cerebrospinal (or central) 72,74 Peripheral 72,78 Sympathetic (autonomic, ganglionic, or vegetative) 37,73 Tissue... 13,73 Neufeld reaction 903 Neuroglia. 73 Neurolemma... 73 Neurology 7 Neurone-s 73 INDEX 997 Page Neurotic-s 179,259 Poisoning by.. 260 Poisons.- 259 Neurotoxin 99 Neutral oxides 693 Neutrophiles 36 Nieotinic acid 583 Nitrates 702 Nitric: Acid 186,701 Poisoning by 266 Oxide 701 Nitrobenzene 724 Nitrogen 701,878 Compounds 183 Cycle 437 Family of elements 700 Monoxide (nitrous oxide) 183 Nitrous: Fumes (chemical warfare) 868 Oxide.. 183,701,739,740 Use as anaesthetic 701 Nomenclature: And classification of chemical compounds.. 679 Of terms relating to male genitourinary sys- tem 510 Non-electrolytes... 669 Nonmetals 686 Normal: Blood chemical standards 892 Electrocardiogram 881 Pulse 280 Salt solution. 193 Salts 685 Solutions 728 Norway or brown rat, control methods 448 Nose: Fracture of 108 Removal of foreign bod y from 119 Nosebleed (epistaxis) 90 Notation 660 Nucleus... 8 Nupercaine hydro'chloride... 736,737 Nurse-s: Appointment of. 760 Corps 752 Operating-room 367 Nursing m, v, 271 Care and procedures, general. 273 Care of communicable diseases 335 Care of delirious 343 Definition of 271 In eye, ear, nose, and throat conditions 330 Methods, principles underlying 273 Qualifications for. 271 Surgical 323 Dressings and dressing surgical wounds... 327 Nutriants.. 179 Nutrient-S— 179 Agar (culture media) 900 Broth (culture media) 900 Enemata 593 Foraminae 15 Inunctions 594 Page Nutrition, definition of 579 Nuts as food 590 Nux vomica 253 Poisoning by... 268 Tincture of 253 Obesity, diet in 592 Obstruction, acute intestinal 127 Obturator foramen 21 Occipital: Bone... 17 Lobe of cerebrum 75 Octet theory 651 (Edematous breathing 283 (Esophagus (gullet)... 52 Officer-s: Chief pharmacists 3, 769,762 Commissioned warrant... 760,762 Dental 760 Medical 760 Of— Hospital Corps. 3,760 Naval hospitals: Accounting 762,775 C hiefs of service 760 Commanding 760 Commissary 762,804 Executive. 761 Of the Day 761 Property 762,775 Ward medical 761 Pharmacists 3,760,762 W arrant 760, 762 Official (pharmacopoeial) preparations 624 Oil-s: Castor 236 Clove 231 Cod liver 237 Cottonseed 236 Fixed . 236 Halibut liver with viosterol 237 Peppermint 230 Santalwood 233 Tar, rectified 231 Theobroma 238 Turpentine 234 Viosterol in 237 Volatile — 230 Wintergreen 232 Ointment-s (unguenta) 633 Blue 212 Boric acid 185 Citrine .. 633 Mild mercurial-.- 212 Strong mercurial 212 Sulfur. 184 Yellow mercuric oxide 211 Oleates (oleata) 628 Olecranon process . 20 Olefin series 721 Oleoresin-s (oleoresinae) 234,628 Natural 234 Of aspidium (male fern) 235 Prepared.. 234 Omentum 53 998 INDEX Operating: Page Gowns 365 Instruments, surgical.. 367 Pad, rubber (Kelly) 321 Personnel- 367 Room (or suite) 356 Adjoining rooms; . Anaesthetizing 359 Cleaning gear.... 360 Instrument 359 Sterilizing. 359 Storeroom. 360 Surgical-dressings 360 Wash or scrub-up 359 And surgical technique m, v, 356 Cleanliness 359 Equipment 357 Heating and ventilation 356 Lighting 356 Nurse 367 Rules, X-ray 966 Operation: Preparation for 368 Preparation of — Operating personnel for. 368 Patient for 323 Local , 323 On morning of operation 323 Preoperative 323 Opisthotonos 268 Opium 249 Camphorated tincture of 249 Poisoning by 268 Powder of ipecac and. 249 Powdered 249 Tincture of.. 249 Opsonins.. 32 Optic foramen... 81 Orbital cavities 16 Orbits (of eyes) 81 Ordnance, Bureau of 752 Organ-s 8,13 Accessory, of digestion 51 Male reproductive . 69 Organic: Acids 225, 720 And their esters . 225,720 Poisoning by 267 Chemistry.. 713 Definition of 713 Materia medica 215 Matter 5,643 Organism-s.. 6 Animal 6 Living 5 Vegetable 6 Organization of: Bureau of Medicine and Surgery 752 Medical Department, expeditionary force.. 565 Medical Department, shore patrol 574 Naval hospitals 757 Clerical force at 773 Commissary department at 805 Ornithodoros moubata (tick) 913 Orthophosphoric acid (anhydrous) 703 Osmosis 657 Page Osteology 7,14 Ovum 9 Oxalic acid, poisoning by 266 Oxidation 695,850 And reduction 695 Oxide-s.. 693 Acidic 693 Basic 693 Metallic. 693 Neutral 693 N omenclature of 693 Per 693 Oxidimetry 732 Oxidizing agents 695 Oxyacids.. 681 Oxygen 183,428, 692,877 Acids. 681 Action and uses 681 And its compounds with hydrogen 183 Oxygenation of blood 48 Oxyheemoglohin 35,49 Ozone 442,694 Sterilization of water by 694 Packs: Cold 313,920 Hot. 311,920 Operating, sterilization of 364 Pad-s: Electric 316 Operating, rubber (Kelly) 321 Palate; Bone 18 Hard. 16,51 Soft. 51 Pancreas 57,63 Pancreatic; Duct.. 57 Juice 57,60 Paper, uses of 446 Paracentesis, abdominal 330 Paraffin 216 Baths 922 Series.. 717 Paragonimus ringed (lung fluke) 909 Paralysants (chemical warfare) 871 Paraphimosis 491 Parasites 374,907 Animal 907 Classification 907 Important diseases due to 917 Malarial, development of 909 Names of.. 907 Parasiticides 179 Parasitism, true 907 Parasitology, animal ; , 907 Terms employedin 907 Parathyroid glands 62 Paratyphoid fever. ...: 404 Parenchyma of kidney 65 Parietal; Bones ' 17 Lobe of cerebrum 75 Pleura.. 49 Parotid glands 62 999 INDEX Page Pasteurization 382,589 Flash method 382 Holding method. 382 Pasturella pestis (Bacillus pestis) 410 Patella 21 Fracture of.. 113 Pathology... 7 Patient-s: Admission to ward, procedures on 353 Bag, baggage, and, hammock 354,355 Bed, turning of 294 Census report of.... 346 Changing clothing of helpless or unconscious. 293 Clothing of 354 Death of, procedures on 355 Discharge from ward, procedures on 355 Effects... 354,834 Inventory of . 354,835 Examination of 355 General care and comfort of 288 Money and valuables of 324,355 Moving and lifting 293 Physical supportive measures 296 Cleanliness of patient 296 Bathing 297 Care of— Back 299 Mouth and teeth 296 Cleansing bath 298 Evening toilet 297 Morning toilet 297 Elimination 302 Food and water 301 Rest, sleep, and exercise 303 Postoperative care of 325 Preoperative preparation of 323 Property of ; 354 Remedying physical discomforts of. 296 Symptoms, observation of... 273 Transferor 353 Transferring from stretcher to bed 294 With infectious diseases. _ 354 Patrol, shore. in, v, 574 Pediculidae. 916 Pediculus: Humanus var. corporis (body louse) 449,916 Humanus var. humanus (head louse)... 449,916 Phthirius pubis (crab louse) 449,916 Pellagra-preventing (P-P) factor 583 Pelvis — 53 Bones of 21 Fracture of... ... 112 Of ureter 68 Penis 70 Pentothal sodium. 745 Pepsin 60,246 Pepsinogen 60 Peptones 60 Percolate.. 623 Percolation :.. 623 Percolator. 623 Percussion 918 Perforating ulcers of: Duodenum 127 Stomach 127 Page Pericardium 28,36 Perichondrium .. 15 Peridental membrane- 169 Perimysium 24 Perineum, muscles of 27 Periodic: Arrangement of elements (fig. 149) 648 Classification of elements. 647 Table. ....... 649 Periosteum. 16 Peripheral nervous system 72,78 Peristalsis 51, 59 Temporary paralysis of 325,326 Peritoneum 28, 53 Parietal 53 Visceral 53 Peritonitis.. .... 326 Personal hygiene.. 371,455 Personnel; Commissary department, naval hospitals... 805 Flying, care of ... 849 Medical department _ 571,759 Operating-room 367 Perspiration. 68,276,553 Characteristics and composition of 68 How described 276 Insensible 68 Physiology of 553 Sensible 68 Petrolatum 215 Phagocyte-s 86 Phagocytosis 35,375 Pharmaceutical: Arithmetic 607 Incompatibility 636 Operations and processes 613 Preparations; Cerates.. 629 Chemical 624 Collodions 625 Decoctions 625 Elixirs. 625 Emulsions 625 Extracts 629 Fluidextracts 626 Galenical 624 Glycerites 627 Infusions 627 Liniments 627 Liquid 624 Magmas 627 Masses 630 Mixtures 627 Mucilages 628 Natural 624 Official 624 Ointments 633 Oleates 628 Oleoresins ■ 628 Pharmacopoeial 624 Pills. 630 Plasters 629 Powders 631 Resins 631 Solid 629 1000 INDEX Pharmaceutical—Continued. Page Preparations: Solutions 618 Spirits 628 Suppositories 632 Syrups 628 Tablets 632 Tinctures 628 Triturations 632 Vinegars 624 Waters 624 Pharmacists (warrant officers) appointment of.. 760 Pharmacodynamics 599 Pharmacognosy 599 Pharmacology 599 Pharmacopoeia, U. 8.: Description of 600 Purity rubic in. 601 Pharmacy — m, v, 599 Definition of 699 Practical 600,638 Theoretical 699 Pharyngeal douche 334 Pharynx 47,52 Phenacetin 225 Phenobarbital 257 Phenol-s (carbolic acid) 222,223 Acetophenetidin (phenacetin) 225 And phenol derivatives 222 Antidote for poisoning by 267 “Carbolic acid” 222 Creosote 224 Creosote carbonate 225 Cresol 223 Disinfectant- 451 Guaiacol. 225 Liquefied 223 Poisoning by.. 268 Resorcinol.. 224 Saponated solution of cresol 223 Trinitrophenol (picric acid) 224 Phenosulfonephthalein 895 Phenyl salicylate (salol) 227 Phimosis 491 Phosgene 706,866 Phosphorus. 580,702 Acids of 703 Amount required in diet 580 Conditions caused by lack of 580 Oxides of 703 Pentoxide 703 White... 866 Photosynthesis 6 Physical: Allergy 489 Change... 652 Disinfection 451 Examination 848 Phenomena of matter, some 653 Therapy in, vi, 917 Physics: Definitionof. 599, 653 Of the march 552 Physiological: Page Chemistry 714 Classification of chemical warfare agents .. 863 Exterior of body 374 Salt solution 198 Physiology: Anatomy and m, v, 5 Definition of 7 Of the march 552 Physostigmine sulfate (eserinc sulfate) 253 Pia mater 73,74 Pickling, in food preservation 817 Picric acid (trinitrophenol) 224, 364 Pillow-s, hospital 289 Pills (pilulae) 630,638 Of ferrous carbonate (B laud’s) 205 Pilocarpine hydrochloride 253 Pilocarpus 253 Pineal body (epiphysis) 63 Pipettes 606 Pits: Ablution 539 Soakage 537 Sullage 639 Urinal soakage 538 Pituitary body (hypophysis) 63 Plague (bubonic, pneumonic, septicaemic) 409 Plasma: Blood 29,30 Composition of . 30 Glycerini 633 Membrane 8 Plasmodium falciparum; malarias; and vivax. 839, 448,908 Plaster-s (emplastra) 629 Mustard (sinapism) 317 Of Paris bandage: Application of 140 Removal of 141 Platelets, blood.. 29 Platyheminthe-s 909 Cestodes (tapeworms) 909 Trematodes (flukes) 909 Pleura 48 Pleurosthotonos 268 Plexus 79 Pneumococcus typing 903 Pneumonia, acute lobar. 341,391 Poison-s: Accidentally or purposely added to food 259 Alkaloidal 259 Classification of 258 Corrosive 259 Definition of 257,259 Efleetsof 257 Food 259, 260, 265, 377 Gaseous 258,260 Handling of 835 Inorganic ' 258 Irritant 259, 260 Ivy.. 481,560 Neurotic. 259, 260 Nonalkaloidal 259 INDEX 1001 Poison-s—Continued. Page Special, food 379 Table of symptoms and treatment . 263 Poisoning; Aconite.. 263 Acute 258 Alcohol; Ethyl 264 Methyl 264 Antidotes 260 Arsenic 264 Atropine 264 Belladonna 265 Bichloride of mercury 265 Causing acute abdominal symptoms 128 Caustic alk alies 265 Chronic 258 Cocaine 265 C olubrine snake. 98 Corrosive 258 Depressants. 260 Digitalis.. 265 Emetics 260 Excitants 260 Food — 260,265,377 Dysentery group 379 Salmonella group 379 Gaseous 258 Gasoline and benzine 269 Heroin 266 Hydrochloric acid.. 266 Hydrocyanic acid gas 266 Hyoscyamus 266 Iodine 266 Irritant 259 Gases 266 Lead 128,266 Mercury 266 Mineral and organic acids 267 Morphine 267 Neurotic 259 Nitric acid.. 266 Nux vomica 268 Opium 268 Oxalic acid 267 Phenol (“carbolic acid”) 268 Stomach tube, use in.. 261 Stramonium 268 Strychnine 268 Sulfuric acid.. 266 S ymptons of 260 By certain poisons, table of 263 Treatment of 260 When nature of poison is unknown 261 Viperine snake 98 oisonous gases, treatment of asphyxiation Pfrom 122 Pollution of soil.. ...... 437 Polybasic acids 684 Polymerism 716 Polymers 716 Polysaccharides 721 Polyvalence 665 Pons (pons Varolil) 76 Pontocaine hydrochloride 737,738 Pork, as food . 588,832 Cuts of 832 Page Porosity, definition of 654 Portal: Circulation 45 System of veins 43,45 Position-s: A ssumed by patient 275 In strychnine poisoning . 268 Fowler's—— — 326 Postmortem examinations __ 840 E quipment for 841 Specimens 843 Postoperative care of patient 325 Post surgeon, duties of 565 Potassium 187,708 Acetate 187 And sodium tartrate (Rochelle salt) 187 Arsenite, solution of 206 Bicarbonate 188 Bitartrate 188 Chlorate. 188 Compounds of 187 Hydroxide. 187 Iodide 186 U se of in Iodine ointment 634 Use of in tincture of iodine 629 Permanganate 189,351,364,509,817 Potential energy. 654 Potter-Bucky diaphragm 957 Pott’s fracture 114 Poultices 316 Poultry, as food 589, 811,833 Cutting of 833 Powder-s (pulveres) 631 Fineness of.. 631 Of ipecac and opium 249 Practical: Hygiene and sanitation 428 Pharmacy; Definition of 699 Hints in 638 Pratique. 454 Preansesthetic medication 746 Precautions, X-ray: Electrical 963 Radiation. 963 Precipitant 621 Precipitate 621 Precipitated: Calcium carbonate (chalk) 201 Sulfur. 184 Precipitation . 621 Precipitins 32 Preparation-s: For— Marches 553 Operation, routine 370 Liquid. 624 Of— Bodies of the dead 843,885,886 Patients for— Anaesthesia 746 Operation 323 Skin for operation 369 Pharmaceutical 624 Preoperative of patient 323 1002 INDEX Prepared:—Continued. Page Calamine.. 203 Chalk 200 Oleoresins 234 Prepuce.. 71 Presbyopia-. 82 Prescriptions: Abbreviations used in writing, table of 635 Definition of 634 Filling of 635,638 Model. 635 Preservation, food 816 Preservatives: Chemical— 817 Used in collection of specimens. 286,890 Preserving, in food preservation... 817 Pressure 655 Blood - 281 Apparatus (sphygmanometer) 281 Diastolic 281 Pulse.. 280 Systolic 281 Filters.. 441 Spots (bedsores). 299 Prevention: Of— Heat stroke.. 115 Infection 96,327,361 Venereal diseases in, v, 511 Preventive medicine, definition of 871 Primary: Haemorrhage.-. 93 Low voltage current 950 Reaction in vaccination 425 Stage, syphilis 493 Procaine hydrochloride 256,736 Procedures; For replacement of typewriters. 789 General clerical, administration and in, vi, 749 Laboratory, and technique in, vi,889 Process-es. 16,71 Acromion. 20 Activated sludge 444 Alveolar. 18,52 Bone, definition of 16 Central 71 Ciliary 82 Condyloid 18 Coracoid 20 Coronoid— 18 Mastoid 16,17 Of— Digestion. 57 Respiration... ...- 49 Olecranon.... 20 Peripheral.. 71 Pharmaceutical 613 Spinous 19 Styloid 20 Transverse.... 19 Trochanter, greater and lesser 21 U. S. P., for making: Fluidextracts 626 Tinctures 628 Xiphoid 19 Page Proctoclysis (Murphy drip) 310 Production of X-rays 942 Products obtained from animal substances... 246 Pronation 24 Prone-pressure method of artificial respiration. 121 Property: Accountability 774 And accounting procedures 774 Care of.. 350,774,783 Hospital supplies and. m, vi, 774 Medical department; Custody of and responsibility for 774,783 Disposition of 783 Procurement of 779,782 Of the dead 834 Office, naval hospitals 775 Officer, naval hospitals, duties of. 775 Patient’s, care of. 354 Surveys, formal and informal. 784 Ward, care of.. 350 Prophylactic-s, venereal disease 179,512 Chemical (medicinal) agents 512 Mechanical 512 Station, shore patrol 575 Tube, U. S. Navy, formula of contents of... 513 Prophylaxis, venereal. 512 Prostate gland 70,490 Prostatitis- 498,502 Protection, X-ray. 962 Protein-s 579 Amount required in diet 579 Conditions caused by lack of. 579 Metabolism of 579 Silver, mild and strong 214 Sources of. 579 Proteoses.. 60 Prothrombin (thrombogen) 33 Protons 650 Protoplasm. 7 Protozoa 907 Provision-s: Accountability for 815 Contracts. 809 Expenditure of 817 Inspection of 809 Issue of_. 809 Procurement of. 808 Storerooms 805,807 Provitamin: A 581 D 582 Prussic acid. (See Hydrocyanic acid.) Pseudomonas aeruginosa (Bacillus pyoeyan- eus) 95 Psychology 7 Ptomaines 248 Ptyalin 59 Pubis. 21 Pulex irri tans (flea) 449 Pulmonary; Artery 38 Pleura (visceral) 49 Plexus 79 Sedatives 179 1003 INDEX Pulmonary—Continued. Page System of veins... 43 Tuberculosis 394 Valve 37 Vein 43 Pulp cavity 167 Pulse. 39,280 Dicrotic. 281 Intermittent 281 Normal 280 Pressure 39,281 Rate (frequency) 280 Regular 281 Tension of... ... 280 Volume of. 282 Full. 282 Full and bounding... 282 Hard 282 Small 282 Thready 282 Pulverization by intervention 618 Pupa-ae 447 Pupil of eye 82 Purchase of typewriter, procedures in 789 Purgatives 179 Drastic 178 Saline. 178 Simple 178 Purification of: Sewage 444 Soil 436 Water 441 Purified talc 199,530 Purity rubric 601 Pus 32, 87 Producing organisms. — 361 Pylorus (pyloric orifice) 54 Pyogenic bacteria 361 Qualifications for nursing 271 Qualitative analysis 724,731 Quantitative analysis 724,731 Quarantine: Definition of... 373 Maritime 454 Quartan malaria 408 Quarterly ration return (Form NMSH 36) 777 Quartz mercury vapor lamps. 926 Questionnaire involving food poisoning 381 Quicksilver (mercury) 209,710 Quinine: Hydrochloride 251 Sulfate —. 251 Rabies 95,419 Treatment of 98 Radiation of beat 429 Radical-s. 665,679,681,682 Ammonium 680 Hydroxyl 680,685 Table of important 680 Radiography 958 Rat-s. 448 Brown or Norway 448 Control measures 448 Ration, military, caloric value of. 523 Page Reaction-s_. 88 Accelerated, in vaccination .... 425 Analytical. 674 Endothermic 1 693 Exothermic 693 Immune, in vaccination 425 Neufeld 903 Of degeneration (R. D.) 931 Primary, in vaccination 425 Serological 496 Serum 375,483 Synthetic 674 RSaumur scale 614 Recapitulation of ledger accounts (Register No. 3) 777 Receptors (nerveendings) 79 Recipes 594 Reciprocal proportions, law of 652 Recruiting in, vi, 936 Rectal anaesthesia 745 Rectification 947 Rectum 55 Red blood cells 29,33 Redistilled water 183 Reducing agent-s 696 Reduction. 6,695 Of— Dislocation.. 103,104 Fracture 105 Oxidation and. 695 Refiex-es - 79 Action... 79 Arc 79 Association (perception) 80 Complex 80 Simple... - 80 Spreading — 80 Tonic 80 Refrigerants- — 179 Refuse 442 Disposal of 445,634 Sewage and.. 442 Shallow burial of. 534 Regional (or local) anaesthesia 735 Register: Charge - 776 Expense analysis... 777 No. 3... - - —- 777 Regular diet 593 Relation of insects, vermin, and rodents to disease and methods for their extermina- tion. - 446 Removal of: Bandages. 133 Dressings 328 Foreign bodies 118,331 Plaster of Paris bandage. 140 Renal: Calyces. 68 Columns 66 Corpuscles (Malpighian bodies) 66 Depressants 179 Papillae 66 Pyramids 65 154294°—39 64 1004 INDEX Page Rennin........ 60 Renovation 373 Report of— A disease 373 Allotment expenditures and obligations (NMS Form B) 778,798 Reproductive organs, male 69 Requisition-s 781 And Invoice, medical supplies and equip- ment (NMS Form 4) 781 Bxireau work request (special M&S form)... 781 For labor (NY O Form 6) 781 Purchase (S&A Forms 76 & 76a and 44 & 44a) 781 Stub — 781,789 Resins (resinse) 234,631 Natural 234 Oleoresins, gum-resins, balsams, and their preparations , 234 Prepared 234 Resistance 952 Resorcinol 224 Respiration 46,282 Apncea.. 51 Asphyxia 51 Cheyne-Stokes 283 Cycle of 50 Expiration 50,282 Inspiration 50,282 Period of rest 50,282 Dyspnoea 51, 283 External 49 How taken 282 Internal 49 Normal rate 282 (Edematous 283 Process of 49 Recording of.. - 283 Regular 283 Singultus 283 Tissue 49 Respiratory: Apparatus - 47 Center 50 Depressants 179 Quotient (R. Q.) 850 Stimulants 179 System, and respiration 46 Tract, diseases of 341 Rest, definition of 303 Restraint appliances 343 Retention: Enemata— Astringent 321 Carminative 321 Method of administration 320 Nutritive 321 Purpose of 320 Sedative 321 Turpentine 321 Of urine. 276,325,501 Retina 82 Reversible reactions. 674 Page Rhei (rhubarb), fluidextract of . 245 Riboflavin 533 Ribs (false, floating, true) 19 Fracture of .. 109 Rickettsia . 916 Mooseri .340,411 Prowazeki 340,411 Quintana .. 340,411 Rigor mortis : , 838 Ringworm 418 Risus sardonicus 268 Roaches 450 Control measures for 450 Rochelle salt 189 Rodents. 448 Control methods for 448 Roentgenoscopy 957 Roller bandages . . 131 Root-s: And tubers as food 590 Of lung 48 Rotation .. 24 Roundworms. (See Nemathelminthes.) Rubber-ized: Garments 446 Gloves, sterilization of 364 Goods, care of 349 Operating (Kelly) pad 321,349 Rings . 300 Sheets 349 Rubefacients 315 Classes of 315 Substances used as 315 Rules for computing doses of medicines 180 Sac, lacrimal . . 81 Saccharides 721 Classes of_. 721 Or carbohydrates . 721 Saccharine substances, sugars and 721 Safety engineer. 516 St. Elizabeths Hospital 758 Salicylic acid 226,817 Saline: Infusion. 594 Irrigation.. 594 Saliva. 62,59 Salivary glands. 52 Salmonella: Group in food poisoning 377 Paratyphi (paratyphoid bacillus A) 404 Shottmiilleri (paratyphoid bacillus B) 404 Salt-s__ 193,680,685 Acid.. 685 Acids, bases, and... 680 Alkaloidal 249 Basic.. 685 Double.. 685 Normal or neutral 685 Solution, physiological (normal) 193 Sanitary: Analysis of water 440 Inspection, on independent duty 887 Inspector, Marine Corps post, duties of 565 INDEX 1005 Sanitary—Continued Page Measures— In the field — 522 With ship’s landing force 572 Supervision, on independent duty 887 Survey— Of water shed 440 On shore patrol 576 Sanitation: Field m, vi, 521 Hygiene and nx, v, 371 Santal, oil of 233 Santonin 245 Saponated solution of cresol 224 Saponification 236,837 Saponins 243 Sapotoxins - 243 Saprophytes 436 Sarcodina 907 Endamoeba histolytica 400,907 Sarcolemma.. 24 Sarcoptes scabei (itch mite) 413,913 Saturated: H y drocarbons 715 Solutions 619,659 Sayre dressing- 139 Scabies 413,913 Scalds... 116 Scales, thermometric 614 Scarlet fever 337,392 Scattering (X-rays) 956 Schaefer’s method of artificial respiration 121 Schilling classification of leucocytes 906 Schistosoma (blood flukes) 909 Hsematobium. 909 Japonicum 909 Mansoni 909 Schizonts- 909 Schneider index 848 School-s; Hospital Corps 763 Naval medical.. - 763 Sclera — - 81 Scopolamine hydrobromide 252, 747 Screens, intensifying 961 Scrotum 69,490 Scrubbing 361 Scrub-up room 359 Sebaceous glands 69 Secondary: Haemorrhage 93 High voltage current 945 Secretary of the Navy. 749 Sediment: Definition of 621 In urine, examination of 891 Sedimentation: In- Process of clarification 441 Purification of water 441 Treatment of sewage 443 Test. 906 Segmentation 9 Selenium 700 Semen. 71 Semicircular canals, ear 83 Semilunar valves. 37,38 Seminal: Page Fluid.. 70 Vesicles _ 70,490 Senses, special . _. 80 Sensitivity, tests for ,, 486,903 Separation, fluids from solids _. 620 Sepsis 86 Septic: Sore throat 393 Tanks 444 Septicaemia 95,340,361 Series: Acetylene 722 Aliphatic ..... 714 Aromatic 714,722 Oarbocyclic 714 Closed-chain 714 Ethylene 722 Homologous 716 Marsh-gas 747 Methane 747 Olefin 721 Open-chain 714 Paraffin- 717 Serology-- 599 Serous membrane 28 Serum-s: Allergy (serum disease) 483 Animal, used in producing passive im- munity 375 Blood 33 Diagnosis of syphilis 495 Sickness 375 Sewage 442 And refuse „• 442 Disposal methods 442 Dry system 442 Water-carriage system 442 Purification methods .... 444 Treatment methods 443 Sheet-s: Changing of lower 291 Draw 291 Changing of 291 Rubber... 289 Drip 921 Rubber 289 Cleaning of... 349 Shigella: Dysenteriae 339,402 Paradysenteriae (Bacillus flexneri) 339,402 Shock 88 Anaphylactic 375 Blocks.... 293 Electrical 88,123 Emotional 88 Symptoms of 88 Traumatic 88 Treatment of 89 Shore patrol m, vi, 574 Dressing stations 575 Equipment for 574 Medical detachment with- 574 Prophylactic station _ _ 575 Sanitary survey 576 Short wave diathermy 933 1006 INDEX Page Shoulder 103,104 Dislocation of 103,104 Methods of reducing dislocation: By traction or extension 104 Kocher’s 104 Stimson’s 104 Showers, rain. 922 Sialogogues.. 179 Sick: Call; On independent duty. 887 Ward, duties at 346 Diets and messing for the.. m, vi, 579 Quarters, Marine Corps posts 565 Siedlitz powder 189 Sigmoid flexure 55 S igns of death 837 Silicon 705,706 Silver. — ... 712 Arsphenamine 505 Compounds of 213 Mild protein 214 Nitrate.. — 213,712 Strong protein 214 Toughened nitrate 213 Simple: Solution 618,627 Syrup 628 Sinus-es_ — 16 Cavernous , 43,87 Coronary 44 Frontal 17 Maxillary. 18 Of kidney 65 Superior saggital. 43 Transverse, or lateral 43 Venous ■ 43,74 Sinusoidal current: Slow.. 930 Surging interrupted 930 Siphonaptera (fleas) 916 Sippy diet. — - 591 Sitzbath 313,922 Skeleton... 14 Bones of 16 Function of. 14 Skin.. 69 Eruptions of, how described 276 Function of 69 Preparation of for operation 323,369 Removal of foreign bodies from. 120 Traction . 160 True 69 Skull: Bones of. 17 Description of.. 16 Fracture of.. 108 Slaked lime 200 Sleep — — 83,275,304 Slow galvanic sinusoidal current 930 Slow sand filter-s 441 Sludge process, activated —.. 444 Smallpox.. 338,422 Vaccine. 425 Storage of.. 426 Smears 901 Page Smell, sense of .. 83 Smokes, irritant (chemical warfare).. 863 Smoking, in food preservation 817 Snake-s: Bites 98 Differentiation, non-poisonous and poison- ous.. 98 Treatment of 100 Colubrine family of. 98 Poisonous, classification of 99 Venom, constituents of— Hsemolysin 99 Haemorrhagin ■ 99 Neurotoxin 98 Viperine family of 98 Soap-s 720 Hard. 238 Liniment. 239 Soft 239 Sodium. 187,707 Benzoate 817 Withcaffeine 255 Bicarbonate. 49,190,707,817 Biphosphate— 191 Bismuth thioglycollate (Thio-Bismol) 209 Borate 191 Bromide.. 192 Carbonate, monohydrated— 192,707 Chloride. 193,707 Physiological solution of 193 Citrate 193 Cyelural (evipal soluble) 745 Fluoride 817 Formaldehyde sulfoxylate— 267 Hydroxide 190,707 Hypochlorite, solution of 196 Diluted solution of 196 Iodide 194 Perborate 194 Phosphate. 194 Salicylate 195 Sulfate 195 Thiosulfate 195 Soft; Diet 593 Soap :.. 239 Soil: And its relation to health and disease....... 436 Bacteria... 436 Pollution 437 Solid state of matter 653 Solidity, definition of 654 Solubility — 659 Of— Gases, law of *. 659 Liquids. 659 Solute. - 618,659 Solution-s (liquores) 618,659 Chemical 618,659 Definition of 659 Hayem’s diluting 905 Of— Calcium hydroxide (lime water).. 200 Cresol, saponated 223 Epinephrine (adrenalin) hydrochloride... 247 Formaldehyde (formalin) 220 INDEX 1007 Solution-s—Continued, Page Of—Continued. Iodine, compound (Lugol’s) 183 Irradiated ergosterol 237 Magnesium citrate 199 Posterior pituitary 246 Potassium arsenite 206 Salt, physiological. 193 Sodium hypochlorite- 196 Dilute 196 Physiological salt 193 Saturated 619,659 Simple — 618 Standard 726 Supersaturated.. 619 Tables of .’ 641 Solvent 618,659 Soporifics 179 Sordes 296 Sore throat 130 Septic 393 Source of infection, definition of 372 Spanish windlass 150 Special: Diet.. 590 Membranes and glands in general 28 Purchase requisitions.. — 782 Senses - 80 Specific: Gravity, definition of— 606 Methods of determining 607 Volume, deflnitionof 607 Methods of determining 607 Weight - 655 Specifics. — 179 Specimens, collection of: Cultures and smears from wounds 288 F or gonorrhoeal smears 288 From the throat 287 General precautions in 286 Of— Abnormal growths 288 Bone fragments - 288 Diseased tissue.. — 288 Fluids. 288 Sputum 288 Stools.... 288 Urine 286 For kidney-function test 287 Use of preservatives in.. 286 Speech — 83 Classification of in delirium. 343 Spermatic cord 70,490 Spermatozoon-oa... 9,63,69 Sphincter pylori. 54 Sphygmomanometer. 281 Spider (“black widow”) 913 Spinal; Anaesthesia 735,736 Column 18 Cord (medulla spinalis) 72,77 Isthmus 77 Nerves 72 Plexuses of — - 79 Page. Spine, fracture of .. 108 Spirilae 901 Spirit (spiritus) 628 Of— Ethyl nitrite . 229 Orange, compound- 230 Splanchnology 7 Spleen 62 And other ductless glands 61 Splenic: Artery—. 41 Flexure— 55 Vein 45 Splint-s 107,148 Aeroplane (abduction)— 163 And appliances 148 Application of 107,148,151 Army hinged half-ring thigh and leg (Keller) 107,149 Pierson attachment for 153 Balkan frame 157 Basswood 164 Cabot posterior leg, wire 107,161 Coaptation 107 Liston long interrupted 153 Materials used for, in emergency. 107 Purposes of 148 Strap, adjustable traction 150 Support and foot rest 150 ‘ • T ”, for fractured clavicle ... 162 Thomas, arm, hinged, traction 107,155 Traction 107,160 Wire, ladder 107,154 Sponge-s 365 Baths. 298 Spontaneous combustion 694 Spores. 901 Sporozoa 908 Hsemosporidia 908 Plasmodium falciparum; malarise; and vivax— 339,448,908 Sporozoites. 909 Sprain-s 101,102 Treatment of 102 Sprinkling filters (sewage purification) ......... 444 Sputum specimen-s: Collection of 288 Stages of general anaesthesia 738 Planes of third stage 739 Stain-s 902 Bacteriological 902 Oram’s 902 Removal of, from— Linens - 351 Sinks, utensils, etc 361 Tissue 902 Staining: Acid-fast bacilli, method of 902 Staphylocci-us 95,361 Starch (cornstarch) , — 239 Statement of receipts and expenditures of medical department property (NMS Form E) 778,796 1008 INDEX Station-s; Page Aid, battalion and regimental 566 Collecting 566 Main dressing, shore patrol 575 Prophylactic, shore patrol 575 Statistics, vital. (See vital statistics.) Steam: Atomizer, uses of 307 Live, sterilization by r. 362 Stenson’s duct 52 Stereoradiographs.. 960 Sterile; Caps.. 365 Gowns, operating 365 Masks 365 Packs 365 Sheets 365 Specimens. 286 Collection of 286 Towels 365 Sterilization 301 Chemical 362 Fractional 362 Mechanical 361 Of— Culture media 900 Milk 589 Rubber gloves.. 364 Sewage 444 Surgical dressings 365 Surgical instruments 364 Sutures and ligatures 365 Water. 441 Thermal 362 Sterilized distilled water 183 Sterilizing: Methods 362 Room. , 359 Stimson’s method for reduction of shoulder dislocation 104 Stimulus-i 8 Stoichiometry 676 Stomach 53 Removal of foreign bodies from 120 Stomachics, (gastric tonics) 179 Storerooms, commissary department 805,807 Strain 101 Treatment of.... 101 Stramonium, poisoning by 268 Strangulation. (See Asphyxia.) Streptococci-us. 95,361 Erysipelatis 341 Haemolytic type 337, 392,393 Hsemolyticus 341 Stroking (eflfieurage) 917 Strong mercurial ointment 212 Stronger ammonia water 196 Strontium.... 708 Strophanthin 244 Strophanthus 244 Strychnine: Poisoning by.. 268 Sulfate 253 Stupes (fomentations) 316 Turpentine 317 Styloid process. 20 Fracture of 111 Page Styptics 179 Subcutaneous: Administration of drugs 181 Feeding 594 Medication. 307 Subjective symptoms.. 274 Sublimate-s 617 Sublimation.. 617 Sublingual glands 52 Submarine: Duty, diving and in, vi, 872 Ventilation 872 Submaxillary glands 52 Substance, intercellular 11 Substitution.. 674 Sucrose. 242 Suffocation (See Asphyxia.) Sugar-s 241 And saccharine substances 241 Tolerance test 897 Suggillation (cadaveric lividity) 837,838 Sulfarsphenamine 207,505 Sulfur... 184,699 Dioxide. 452,700 Family of elements. 698 Flowers of. 184 Hydrogen sulfide 699 Ointment. 184 Precipitated 184 Washed. 184 Sulfuric: Acid „ 186,700 Dilute 186 Poisoning by .. 266 Preparation of 186 Ether 719 Summary of symptoms and first-aid treatment of casualties caused by exposure to chemical agents 864 Sun stroke. (See Heat stroke.) Supervision, commissary m, vi, 804 Supination 24 Supplies and Accounts, Bureau of 752 Supplies and equipment, medical department: Custody of 775 Disposition of- . 783 Procurement of. 779 Supplies ledger 776,777 Suppositories (suppositoria) 632 Suppression of urine 276 Suppuration ..... 361 Suprarenal (adrenal) glands 62 Surface: Anaesthesia- 735 Tension 658 Water. 438,528 Surgeon-s general, U. S. Navy.. 750,757 Surgery, aseptic 360 Surgical; Dressings 327,364 Dry 328 Hot wet. 328 Packs 365 Pads 365 Sponges 365 Wet 328 INDEX 1009 Surgical—Continued. Page Lubricant 240 Formula for 240 Nursing, definition of 323 Technique 360 Aseptic. 360 In operating rooms 360 Wounds 327 Aseptic 371 Dressing tray.. 329 Contents of 329 Septic. 360 Susceptibility 376 Causes of 376 Susceptibles. 373 Sutures 97,365 Sweat. (See Perspiration.) Sweat Glands 69 Switch, X-ray 953 Symbols, chemical 661 Sympathetic nervous system 37,73 Symphysis pubis.. 21 Symptoms 274 Objective 274 Observation of 273 Of poisoning by certain poisons, table of 263 Subjective 274 Syndesmology 14 Synovial: Fluid.. 22 Membrane 22,28 Synthesis 6,653 Synthetic reactions. 674 Syphilis 416,493 Diagnosis of 495 Infection, sources of 494 Initial lesion of 493 Stages of 494 Symptoms of.. 494 Treatment of 494 Syrup (syrupus) (flavored, medicated, and simple) 628 System-s 13 Blood-vascular 29 Digestive 51 Lymph-vascular 45 Nervous 71 Of veins 43 Respiratory 46 Urinary 63,65 Systole 37 Table-s; For calculating food requirements, marching men 558 Of— Abbreviations of Latin words 635 Average heights and weights 584 Binary or hydracids 684 Bones of— Cranium... 17 Face.. 17 Lower extremity 21 Neck and trunk.. 18 Skeleton 15 U pper extremity 19 Tables—Continued. Page Of—Continued. Botulism and food infection, differences between 380 Common indicators. 731 Contents m Cranial nerves 72,78 Elements (atomic weights and numbers, symbols, etc.) 660 Elimination diets 489 Enzymes 59 Poods on naval hospital menus 820 Formulas, valences and names of im- portant radicals 680 Hydrogen and oxygen acids 681 Pathogenic organisms and diseases caused by .. 904 Poisons, symptoms and treatment 263 Symptoms of poisoning by certain poisons. 263 T ernary or oxyacids 684 Water requirements on the march... 557 Weights and measures, equivalents of 604 Showing- Amounts of mineral salts and vitamins in adequate diet 586 Analysis (composition) of adequate diet.. 587 Number of drops obtained from standard dropper 606 Periodic arrangement of the elements (fig. 149) 648 Valence of certain elements combined with hydrogen 664 Variation of oxygen valence of sulfur and osmium 665 Solution 641 Tablets (tabellae) 632 Of— Mercury bichloride, large 211 Mercury bichloride, small 212 Taenia saginata; and solium (beef and pork tapeworms) 909,910 Taeniacides 179 Talc, purified. 199 Tanks: Fresh water: Care of ... 440 Cleaning of.. 440 Sewage disposal: Emscher.. 443 Imhoff 443 Single-story septic... 443 Two-story septic.... 444 Tannic acid 227 Formulas for: Compound solution of 228 Jelly. 116,228 Tapeworms, (See Cestodes.) Tapotement 918 Tar, rectified oil of 231 Tarsal; Bones 22 Cartilage. 22 Tartaric acid 228 Taste: Buds 83 Sense of. 83 1010 INDEX Technique: Laboratory procedures and.. _i. in, vi, 889 Of— Basal metabolism 854 Blood grouping 858 Electrocardiography. 880 Surgical 360 Operating room and 356 Teeth 52,166 Apex 167 Bicuspid 52,166 Canine ■ 52,166 Crown.. 166 Cusps ... 167 Deciduous (milk) , 52,166 Incisor 52,166 Molar 52,166 Neck 166 Peridental membrane 169 Permanent 52,166 Root and root canal . . 166,167 Structure of.. .. 166 Temperature 278,614 Absolute. ... 614 Body 278 How measured 278,614 Methods of taking 279 Normal 278 Recording of 283 Effective 874 Rules for converting 615 Trays 278 Temporal: Bones. 17 Lobe of cerebrum 75 Muscle 27 Tenacity, definition of 654 Tendons .... 24 Tenon, capsule of 28 Terminal disinfection 336,373 Ternary: Acids.. 684 Compounds 679 Terpin hydrate.— 234 Testes (testicles; male gonads) . 69,490 Inflammation of. 128 Test-s: Agglutination 903 Blood sedimentation 906 Dick 904 Duodenal drainage 898 For— Albumin in urine 1 890 Glucose (sugar) in urine 890 Hypersensitiveness 474 Frei. 904 Friedman 904 Functional 893 Gastric analysis 897 Kahn flocculation 495 Kidney function 893 Blood nitrogen retention 893 Concentration 894 Dilution 893 Test-s—Continued. Page Kidney function—Continued. Mosenthal. 894 Phenolsulfonephthalein (phthalein or red). 287,895 Sugar tolerance 897 Urea clearance 897 Liver function.. 898 Bromosulfalein dye 898 Galactose 898 Icterus index 898 Urobilinogen 899 Van Den Bergh 898 Mantoux 487,904 Moro’s 488 Paul and Bunnell .. 904 Schick 904 Sensitization 903 Tuberculin 487 Von Pirquet 488 Wassermann complement fixation 495 Tetanus. 95,340,426 Antitoxin 426 Bacillus of (Clostridium tetani) 426 Toxoid 426 Theobroma, oil of 238 Theoretical pharmacy __ 599 Therapeutic-s: Definition of . . . 599 Dose 180 Empirical 177 General. 177 Incompatibility ... 637 Materia medica and m, v, 177 Pools and tanks (physical therapy) 923 Rational.. 177 Treatment.... 311 Therapy: Artificial ultraviolet ....... 926 Diet 590 Electro 924,928 Helio. 926 Hydro 920 Light... 924 Mechano 917 Physical ni,VT,917 Thermal sterilization 362 Thermometer-s: Centigrade : 614 Clinical 278 Care of 278 Disinfection of 278 Fahrenheit.. .... 614 RSaumur 614 Scales used in marking 614 Thiamin (vitamin Bi; aneurin). 582 Thio-Bismol 209 Thoracic: Duct 46 Vertebrae (dorsal) 18 Thorax 19 Throat, removal of foreign bodies from 119 Thrombin. 33 Thrombocytes 29 INDEX 1011 Page Thymol 233 Iodide 233 Thymusgland 62 Thyroid: Cartilage 47 Gland. 62 Thyroxin 851 Ticks 913 Tin 710 Group of elements 710 Tincture-s (tinetura) 628 Of— Aconite 254 Benzoin, compound 235 Capsicum 233 Cardamon, compound 231 Cinchona, compound 250 Digitalis 244 Ferric chloride 204 Ferric citro-chloride, tasteless 205 Gentian, compound 245 Green soap 239 Iodine 182 Mild 182 Myrrh 235 Nux vomica 253 Opium.. 249 Camphorated 249 U. S. P. processes fof making 628 Tissue-s 8,9 Blood and lymph 11,13 Connective 11 Adipose 11 Areolar 11 Cartilaginous 11 Elastic 11 Fibrous. 12 Lymphoid.. 12 Osseous (bone) 12,14 Cancellous 14 Compact. 14 Epithelial (epithelium).. 11 Ciliated 11 Columnar 11 Cuboidal =.. 11 Flat — 11 Glandular (secreting) 11 Protective 11 Simple 11 Squamous... 11 Stratified. 11 Fluid. 8 Muscular. 11,13 Cardiac, (striated (striped); involuntary). 13 Nonstriated ((unstriped); involuntary)... 13 Properties of— Contractility 13 Extensibility. 13 Irritability 13 Tonicity 13 Striated ((striped); voluntary) 13 Nervous (nerve) 11,13,72,73 Toluene (urine preservative) .. 890 Page Tongue . . 52 Tonics jso Tonsil... 52 Toothache- 172 Torrefaction 616 Torsion: Balance. 606 In heemorrhage 90,91 Tourniquet, use of 91 Toxic dose. igo Toxicology m, v, 257,599 Toxins ..... 32 Trachea (wind pipe) 43 Trachoma 427 Traction: Or extension in dislocation of shoulder 104 Skin. 160 Splints 160 Tragaeanth 240 Transfer: Of medical department property. 788 Voucher: Issued (T. V. I.) 788 Received (T. V. R.) 733 Transparency: Definition of : 654 Of urine 890 Transportation: Charges 788 Of remains 780 Treatment: Of boils 87 X-ray 962 Trematodes (flukes) 909 Clonorchis sinensis 909 Fasciolopsis buski .. 909 Paragonimus ringeri 909 Schistosomes. 909 Trenchmouth 174 Treponema pallidum (Spirochaeta pallida) _ _ 416,494 Tribasic acids 684 Trichinella spiralis (Trichina spiralis) 420,912 Trichinosis 420 Trichophyton : 418 Trichuris trichiura (whipworm) 912 Tricresol 223 Tricuspid valve 37 Trihydroxy benzene; a, s, and v 723 Trinltrophenol 224 Trinitrotoluene, poisoning by 269 Trisaecharides ; 721 Triturations (triturationes) 617,632 Trochanter, greater and lesser . 21 Trophozoites 909 Troy weight 602 Trunk and neck, bones of 18 Trypanosoma gambiense ... 907 Trypanosomiasis 908 Tryparsamide 207,505 Trypsin 60 Trypsinogen 60 Tubercle (bony process) 16 Tubercle bacillus, staining of, 902 1012 INDEX Tuberculosis: Page Diet in. 592 Other than pulmonary. 396 Pulmonary. 394 Tuberosity, (bony process) 16 Tubes: X-ray - - 942 Eustachian or auditory— 62 Turpentine: Oil of 234 Retention enemata.. 320 Stupes 317 Tympanic membrane 82 Typewriters, procedures for replacement of... 789 Typhoid fever 338,406 Typhus fever 340,411 Ulcer: Perforated gastric or duodenal 127 Ultra short-wave diathermy 935 Ultraviolet: Radiation - 925 Rays - 442 Therapy (artificial).. 926 U nconsciousness — 122 Caused by acute alcoholism. 125 Hysterical 124 Symptoms, differentiating '. 123 Treatment of - - 123 Unit, British thermal (B. T. U.) 693 Unsaturated hydrocarbons 721 Upper extremity, bones of. 19 - 65 Clearance test 897 Ureters 68 Urethra 68 Urinal 303 U analysis 889 And blood chem istry 889 Urinary; Bladder - 68 Meatus 71 System.. - 63,65 Instrumentation of 506 Urine --- - - 64,276 Abnormal constituents in... 65 Characteristics of normal 64 C omposition of normal 65 Examination of.... - — 890 Microscopical — 891 Preoperative and postoperative 324 Routine 890 Special tests 891 N ormal — 64,889 Rentention of 276, 325, 601 Specimens, collection of 501 Suppression of — 276 Uriniferous tubules 66 Urotropin (methenamine) 220 Urticaria , 478 Uvula.. 52 Vaccination 424 Method of 424 Results of 425 Vaccines 246,374 Page Valence . 664 Of certain elements combined with hydrogen. 664 Oxygen, of sulfur and osmium, variation of. 665 Valuables, patient’s 355,834 Valves of heart.. 37 Vaporization 616 Vascular system: Blood 29,36 Lymph. 45 Vas deferens (ductus deferens) 70 Veal, as food .’ 588,830 Cuts of 830 V egetables as food 589 Vein-s 38 Axillary 44 Azygos 44 Basillic 44 Median (median cubital) 44 Brachial 44 Cephalic „„ 44 Deep 43 Femoral 44 Deep.. 45 Hepatic 45 Hypogastric (internal iliac) 45 Iliac, common, external, and internal (hypo- gastric) 45 Inferior vena cava 38,45 Innominate-—, 44 Jugular, anterior, external, and internal 43 Lumbar ... 45 Median 44 Of systemic circulation. ... 43 Ophthalmic - 81 Ovarian... 45 Peroneal 44 Popliteal- 44 Portal 45 System of. 43,45 Pulmonary. 43 System of 43,45 Radial - 44 Renal .... 45 Saphenous: External, small, or short 44 Internal, great, or long.... 44 Spermatic 45 Splenic 45 Subclavian... 44 Superficial 43 Superior mesenteric 45 Superior vena cava 38,44 Suprarenal. 45 Systemic system of 43 Tibial, anterior and posterior 44 Ulnar 44 Velpeau bandage 137 Venereal: Diseases 414,490 Chancroid 414,495 Genitourinary and in, v, 490 Instrumentation in . 504 INDEX 1013 Venereal—Continued. Page Diseases—Continued. Gonorrhoea 414,496 Acute (clap)... 496 Complications of 497 Balanitis. 501 Balanoposthitis 501 Epididymitis 498 Gonorrhoeal ophthalmia. 332,502 Paraphimosis 501 Phimosis 501 Prostatitis 497,502 Stricture of urethra. 498 Chronic (gleet) 497 Lymphogranuloma venereum (inguinale) 415,503 Prevention of in, v, 511 Syphilis 416,493 Verruca acuminata, venereal 504 Prophylaxsis — 612 Venous: Arch, dorsal. - 44 Blood 38,43 Channels (sinuses) 43,87 Plexus, volar... 44 Sinuses.. ..' 43,74 Ventilation 432 Aboard ship. 432 Artificial 432 Ashore 432 Natural 432 Of— Operating rooms 356 Submarines 872 Wards 352 Ventricle-s; Of— Brain 75 Heart — - 37 Venules 38,43 Vermes (worms) 909 Vermicides 180 Vermifuges. - 180 Verruca acuminata, venereal 504 Vertebrae: Cervical 18 False - 18 Lumbar 18 Thoracic (dorsal) — 18 True - 18 Vertebral: Arch IS Column, bones of 18 Foramen 19 Vertebrates - 6 Vesical: Sedatives 180 Tonics 180 Vesicant-s 318 Gases (chemical warfare) 868 Vessels: Blood — — 36,39 Lymph 46 Of blood-vascular system 36,39 Vestibule (internal ear) — 83 Page Veterans’ Administration hospitals 758 Vibrio comma (Spirillum cholera) 339,399 Villi. 54 Vincent’s infection, oral.. 174 Vinegars (acetae) 624 Vlosterol: Halibut liver oil with 237 In oil. 237 Virulence 374 Virus: Filtrable 901 Vaccine.. 246,374 Viscera, animal, as food 689 Visceral pleura. (See Pulmonary pleura.) Viscosity 658 Visual; Apparatus 81 Centers 81 Vital statistics 456 Compilation of statistical data 464 Graphic methods for presenting 456 Interpretation of 467 Of the Navy, subject matter of. 458 Other terms used in statistical work 459 Population.... 459 Purpose of 459 Rates used in 459,460 Standards of comparison of statistical facts.. 459 Use of 459 Vitamin-s 527,581 Amounts required in adequate diet 581 Antihsemorrhagic (K) 581 Antineuritic (thiamin; aneurin; Bi) 582 Antirachitic (D)_. ... ... 582 Antiscorbutic (ascorbic acid, cevitamic acid; C) 582 Antisterility (E) 583 Conservation of 527 Daily requirements of 582,583 Designation of 581 Effects of in life and health 581 Pellagra-preventing (P-P) factor (nicotinic acid) 583 Riboflavin (Q, and Bj) 583 Sources of .. 581 Vitreous body 82 Vocal cords (false and true) 47 Voice: How described 275 Organ of — 47 Volar venous plexus 44 Volatile: Oil drugs, and preparations made from 230 Oils 230 Voltmeter , 952 Volume 554 Gram-molecular (molar) 663 Specific 507 Volumetric procedures 731 Vomiting 275 Voucher-s: Issue (NMS Form R) ... 777 Public 787,791 1014 INDEX Voucher-s—Continued. Page Receipt and expenditure (for commissary ledger, NMS Form 37) 815 Transfer (usually S&A Form 71) 781 Issued 788 Received. 788 Ward-s: Cleaning t 347 Care of cleaning gear and materials 349 Care of equipment and utensils 349 Daily. 347 Dusting.. 347 General field day 347,349 Of— Floors and walls 348 Rubber sheets and other rubber articles. 349 Special daily ,. 347 Drug book 346 Duties: Daily. 345 Of persons in charge of.. 344 General care of 352 Arrangement of furniture and utensils 352 Care of furniture and furnishings 352 Cleanliness 347 Freedom from unpleasant odors 352 Lighting : 352 Temperature 352 Ventilation 352 General inspection of 350 Linen 350 Changing of 350 Damaged 350 Exchange of soiled for clean 350 Inventory of, weekly..., 350 Issue of clean 360 Of patients with communicable diseases . 349 Removal of stains from 351 Management . ra, v, 344 And general supervision of 344 Assignment of personnel ... 345 Cleaning routine 347 Responsibility for successful 344 Schedule of work in. 344 Property 350 And linen 350 Care of 350 Inventory of, monthly 350 Missing 350 Record of__ 350 Transfer of 350 Warfare, chemical in, vi,862 Water-s (aquae) 57,183,527, 573,624,694 Analysis of, sanitary 440 Boiling, sterilizing by , 532 Discipline on the march 557 Distilled 183, 624 Examination of.. .... 440 Interstitial 622 Of crystallization.... 622,695 ■ Redistilled 183 Relation of to health and disease 437 Shed, sanitary survey of 440 Sources of _T 437,528 Sterilized distilled. 183,624 Water-s—Continued. Page Stronger ammonia „ 196 Surface. 438,528 Weighing-. 602 Weight-s .. 602,605,654 And measures, table of equivalents of 604 Definition of 602 Grain .' 602 Gram. 603 Gram-molecular (mole) 663,727 Specific 655 Well-s. 438,528 Artesian 438 Deep.. 528 Shallow 438,528 Water 529 Wet dressings 95 Wharton’s duct 62 Whiskey 219 White: Blood cells 35 Matter 74 Phosphorus 866 Wax.. 238 Whooping cough 397 Wool.. • 446 Fat 238 Work request, bureau 782 Wound-s 93 Bacteria causing infection in 93,94,95 Bites of— Poisonous insects 93,98 Poisonous snakes 93,98 Rabid animals 98 Clean or aseptic 93 Contused 94 Crushed 94 Dressings 95 First-aid treatment of 93 Gunshot... 94,100 Healing. .1 ... 94 Factors preventing 94 First and second intention 94 Incised 93 Infected or septic 93 Irrigation of 330,362 Lacerated. 93 Of— Abdomen 100 Chest 100 Eye. 100 Poisoned 93,98 Punctured 94 Sutures.. 97 Treatment of: General principles underlying 94 Wucheria bancrofti (thread worm) 912 Xenopsylla cheopis (flea) 410,449 X-ray-s in, vi, 940 Darkroom 960 Equipment: Arrangement of 954 Shockproof 954 INDEX 1015 X-ray-s—Continued. Page Examinations .. 103,954 Fluoroscopy ... 957 Potter-Bucky diaphragm 957 Radiography. ... 958 Scattering of ,•... 956 Film-s.... 958 Exposures 955 Nature of 941 Production of 942 Primary low voltage current 950 Secondary high voltage current 945 X-ray tubes 942 Protection 962,965 Electrical precautions. 963 Radiation precautions.. 963 X-ray-s—Continued. Page Switch 953 Treatment 962 Yards and Docks, Bureau of 751 Yellow: Fever 340,412 Mercuric oxide 211 Young’s rule . . 180 Zinc i 710 Chloride 203 Compounds 202 Oxide 202,710 Stearate 203 Sulfate 202,710 Zoology 7,599 Zygomatic arch . . 16