[Reprinted from the American (iYNajcoLOGicAL and Obstetrical Journal for January, 1895.] PUERPERAL SAPR^EMIA.* Edward P. Davis, A. M., M. D. The parturient patient is exposed to animal poisons not only in the form of infective germs conveyed to her by her attendants, but also from certain toxines which accompany the process of putrefac- tion. Injuries occurring during labor render the tissues of the birth- canal in a peculiarly favorable condition for putrefaction, while foetal death places within the body of the patient a mass of tissue ready to putrefy, and affording favorable material for the development of bac- teria. A recent work upon pathology (Hamilton) calls attention to the fact that a patient may absorb toxines secreted by germs growing upon a putrefactive focus before these germs have themselves found their way into the blood. Such a condition of poisoning is termed sap- raemia. The causes of this condition are those which produce necrosis of tissues, and introduce into these necrotic tissues infective germs. The fate of these germs will depend very much upon the condition of the patient’s blood-serum. In some, the bacteria of suppuration grow luxuriantly, and abscess formation and pyaemia promptly follow : in others, while bacteria may flourish upon the patient’s tissues, they fail to increase rapidly in number. The products secreted by these bac- teria comprise the toxines of sapraemia. Practically speaking, sapraemia is most often observed after tedious labor in which injury to the soft parts of the mother has taken place. In fifty-three cases Winter observed twenty-five in women having contracted pelves : thirteen had abnormal presentation of the foetus, and in but six cases were the pelvis and maternal soft parts normal Labor was terminated in but one of these cases in twelve hours, the remainder continuing from twenty to one hundred hours in partu- rition. Close observation of the interval elapsing between the end of labor and the first symptom of poisoning shows that the danger of ab- sorption begins ten hours after labor. Ahlfeld enables us to judge of * Read before the Philadelphia Obstetrical Society, December 6, 1894. 2 Edward P. Davis, M. D. the comparative influence of various obstetric operations upon the production of sapraemia, by his table from which we learn that manual removal of the placenta and membranes is most apt to be followed by sapraemia. Next comes perforation and extraction, then prolonged forceps delivery, and least dangerous are induced labor and version and extraction. A familiar example of this disorder is seen in cases delivered spon- taneously, where the patient may remain for some time without proper attention : these patients usually inhabit dirty dwellings which, with their contents, furnish abundant growths of the less poisonous bac- teria. Very often it will be found that the patient has been subjected to examination without antiseptic precautions : in other cases, the pa- tient has remained exempt from examination, but lying upon a bed anything but clean, and in surroundings best calculated to further the growth of bacteria. In some of these cases, haemorrhage, by im- poverishing the patient’s blood, has rendered her peculiarly suscepti- ble to rapid absorption. An excellent clinical description of sapraemia is that given in 1880 by Matthews Duncan* who calls attention to the rapid effects follow- ing the absorption of sapraemic poison, and also to the prompt subsid- ence of the symptoms. The clinical signs of sapraemia are a foul dis- charge, fever, rapid pulse, with usually tenderness over the uterus. Rigors and delirium are present in severe cases. Pain is not a pro- nounced symptom; constipation or diarrhoea may be present, gener- ally the latter. The comparatively sudden onset of the disorder, and the rapid pulse, give evidence of a toxaemic poison quickly absorbed, rather than the gradual development of bacteria. The pathology of this affection has been well studied by Bumm ; f microscopic sections from the endometrium of such a patient shew the outer layer of the endometrium swarming with bacteria, while just internal to this layer we find an abundant round-cell formation of granulation tissues which is the rampart thrown out by Nature to prevent the further penetration of invading micro-organisms. Ahlfeld l in his excellent description of this form of puerperal sepsis makes the statement that in well-conducted Maternities, the number of cases of fever from auto-infection and sapraemia occurring during the puerperal period is greater than the number of cases having * Matthews Duncan, iMticet, October 30 and November 6, 1880. f Bumm, /irchiv f. Gynak., 1891, Bd xl, Heft 3. j Ahlfeld, Zeit. f. Geb. u. Gynak., 1893, Bd. xxvii, Heft 2. Puerperal Saprcemia. 3 fever from direct contagion. He further remarks that the mucous membrane of the uterus absorbs with extraordinary vigor its septic contents, the poison most often entering through the cervix and en- dometrium, and that next in rapidity of absorption is the mucous membrane of the vagina. His experience shows that the poison thus absorbed is often rapidly eliminated, frequently by the kidneys. Patho- genic germs present in the genital tract before labor find a favorable culture medium in the decomposing fluids of the vagina and uterus. Winter,* in describing the sudden occurrence of absorption and fever, narrates a case in which a sharp chill followed incision into the cer- vix. The pulse is remarkable in these cases for its rapidity which is not in proportion to the temperature curve. The patient first com- plains of sensations of heat, headache and languor, followed by sweat- ing, and often diarrhoea : the prognosis, with these symptoms, Winter considers favorable, if the cases are taken promptly in hand. The differential diagnosis of sapraemia in contrast with septicaemia and pyaemia may be stated briefly as follows : In sapraemia, the symp- toms are those of the decided effect produced by the sudden absorp- tion of a toxine : in septicaemia, the absorption is more gradual, and is aggravated by the rapid development of septic germs. These germs, proceeding from the uterus to its surrounding tissues, form the foci of infection in the various organs of the body. The course of the case of septicaemia is more .gradual, the fever showing remissions and ex- acerbations. In pyaemia, the symptoms of septicaemia are further in- creased by the signs and symptoms of abscess formation : embolism and thrombosis cause multiple abscesses in the viscera or joints. The treatment of sapraemia should be prompt and thorough. As the retained and decomposing tissue, from which are absorbed the toxines producing the disorder, is in the birth-canal, the first step is to effectually empty and cleanse this region. Matthews Duncan ad- vises the introduction of the fingers within the womb, or that tenac- ulum-forceps be inserted, with which the obstetrician may endeavor to grasp retained and decomposing material. For cleansing and emptying the uterus, the finger may be well replaced by the intra-uterine puerperal curette : as this is a douche- curette, the obstetrician is enabled to cleanse and antisepticize the cavity of the uterus while removing retained and decomposing ma- terial. Such a curette should be large, with an edge no sharper than that of a good paper-cutter, and made entirely of metal. Reference * Winter, Zeit. f. Geb. u. Gynak., Bd. xxiii, Heft i, 1892 Edward P. Davis, M. D. 4 to the histological studies of *Bumm illustrates the effort which Nature makes to prevent the penetration of micro-organisms into the lymph- spaces of the uterus by forming a layer of granular cells beneath the germs. Remembering this fact, it is well for the obstetrician not to remove this layer of tissue with the curette, but to content himself with scraping the interior of the uterus with a blunt instrument, thus washing away bacteria and dtbris, while avoiding the opening of the lymphatics and blood-vessels of the uterus. In cases of sapraemia, this cleansing of the womb may often be done without an anaesthetic, as there is not in these cases the acute pain of beginning peritonitis. The antiseptic agent to be employed in this cleansing is, preferably, one of the phenols ; carbolic acid, creolin, lysol, kresin or trikresol may be used : trikresol has the advantage of being colorless, exceed- ingly efficient, and free from poisonous effects, if used in solutions of one half to one per cent. At least a half gallon of the hot antiseptic solution should be employed, the douche-curette thoroughly but gently scraping the interior of the womb, while the antiseptic fluid thoroughly flushes the diseased tissue. It is unnecessary to use a tenaculum- forceps to grasp the uterus in these cases, and a speculum is also superfluous : the hand upon the uterus above the pubes can best ap- preciate the impact of the curette. There is no trouble in these cases in securing the prompt reflux of the antiseptic without the use of an intra- uterine catheter : the fluid will return freely alongside of the curette. A comparative estimate of the value of sublimates and the carbolic substances in the treatment of sapraemia may be gained from the ex- amination of a series of cases in which it is shown that of those pa- tients who received sublimate douches, twenty-five per cent, had a normal puerperal peiiod : of those who were treated by disinfection with carbolic acid, thirty-nine per cent, speedily recovered from sap- raemia, and had a normal puerperal period. Following the antiseptic cleansing of the uterus, which should be done in the most thorough manner, it is advantageous to pack the uterus with iodoform gauze, or to leave within the uterine cavity a suppository containing sixty grains of iodoform, aristol, boric acid, or iodol. The further anti- septic treatment of the case consists in cleansing the external parts three times in twenty-four hours with sublimate solution (i to 2,000), and in keeping a sublimate occlusion dressing over the vulva. If the disinfection of the birth-canal is thoroughly done, it will rarely be necessary to repeat it; should, however, exacerbation of fever indi- cate fresh absorption, the treatment should be repeated. In addition, the lymphatics of the peritonaeum should be thoroughly drained by Puerperal Saprcetnia. 5 saline purgation, and a copious amount of normal saline solution be given to the patient either by transfusion, by the mouth, or by copious rectal injections. Strychnine, ergot and alcohol are valuable aids in assisting the patient to resist the poison. Sapraemia may seriously complicate labor where parturition is pro- longed, and may furnish a positive indication for the speedy delivery of the patient. Interference in these cases is indicated not only in the interests of the mother, but in the interests of the child. Observa- tion has shown that twenty-two per cent, of children during whose birth sapraemia occurs, perish from intra-uterine poison ; if observa- tion of these cases be further extended to the ultimate results of this intoxication, a foetal mortality of thirty-five per cent, has been re- corded, as children who may survive birth in these cases perish sub- sequently of septic pneumonia, umbilical infection and septic dis- orders of the blood. The symptoms of sapraemia during labor are those already described in the puerperal patient. Spontaneous labor usually ceases, or uterine contractions become markedly deficient. In view of the increased risk to the child, it is well to deliver the mother in these cases with the least possible risk to herself, version, or the forceps being indicated. Increased risk in symphysiotomy occurs in these cases from the dangers of septic absorption in the symphysioto- my wound. In highly contracted pelves where labor is complicated by sapraemia, the child should be delivered by abdominal incision, followed by amputation or removal of the uterus. The prognosis of post-partum sapraemia depends greatly upon the promptness with which the condition is treated. In fifty cases of this disorder, Winter had four deaths : nineteen of these cases had a nor- mal puerperal period after the thorough cleansing of the uterus : twenty-seven had fever during their recovery. The prognosis of labor complicated by sapraemia also depends very largely upon the good judgment and skill of the obstetrician : when the condition is recog- nized, and the patient promptly and skillfully delivered, her chance for recovery should certainly be but little imperiled by this complica- tion : when, however, she is allowed to linger in impossible labor, or is subjected to fruitless and violent interference, as in repeated for- ceps applications in contracted pelves, the mortality rate becomes high.