129 V. PROCEEDINGS OF THE CONSULTANTS * COMMITTEE ON FORENSIC MEDICINE Translation prepared by: U. S. Naval Technical Unit, Europe, (Medical Section) Office of the Naval Advisor Office of the Military Government (U. S.) 130 1. Death caused by exposure to excessive heat, and from combustion. Effect of heat, Reeierungs-Rat (Government Counsellor) BUETTNER The large number of fire catastrophes in aerial warfare can be explained by the fact that the enemy finds the means of warfare by fire available, which he has only to ignite. Eadh flame has at its base glowing parts which emit gas, by which it keeps itself supplied as by a gas-works. The flames of wood-, petrol, and oilfires show temperatures of about 600 - 800 Celsius degrees. Much higher temperatures are found with metal fires such as the incendiary bombs, with which temperatures may increase to 3000 Celsius degrees. Only a slight part of the radiant heat emitted is visible, and in such a way that e.g. at 700 Celsius degrees red heat and at 1100 Celsius degrees yellow heat is shown. For feed- ing the fire, immense quantities of fresh air are needed which are conveyed from'.the side and from below as the so- called "torrent of flames". This air is primarily cold, pure, and rich in Oxygen. A scarcity of oxygen in the cent- er of the fire is, therefore, improbable. The term "Feuer- sturmleiche" is misleading, since these people are mostly killed not by the "torrent of fire", but by radiant heat. Tie heat acts on the human body by conduction and. con- vection of hot air, by contact with solid and liquid matters, by cordensing vapors, but above all by radiation. The effect of the hot air increases with the velocity of the wind. Practically, however, it obtains dangerously high values only in closed rooms and immediately over the flame. The combined effect of the humidity of the air, the proportion of dust and foreign gas is in this case generally insignific- ant in our climate. For physical reasons (in consequence of the steeply rising curve of the transmission of heat with increasing temperature) as well as from the way in which the fire is built up (hot air above) the result is that the main trans- mission of heat takes place by radiation. The intensity of the absorption of radiant heat is determined by the temper- ature and the expanse of burning surfaces (calculated from the angle of vision of the observer) and by the absorption coefficient of skin and clothes. Clothes and skin have practically no capacity of reflection nor perviousness to the radiation of heat. Polished metals, however, prevent the effect of radiation by a nearly total reflection. With each testing of the effect of heat and. the pro- tection against heat it must be clear what the various con- ditions are. In particular the relative effect of hot air and radiation must be defined, e.g. if the supply of calories and the temperature of the skin are the same, the hair on this skin in case of a calory supply with hot air, will be con- siderably hotter than the skin, while in case of radiation they will be colder than the skin. 131 A protection against the effect of heat is primarily afforded by any kind of clothing as it makes possible a fall of temperature from the hot outside to the inner side, according to its insulation against heat. The desirable high insulation for heat does, however, increase the probab- ility of catching fire with clothes which do not consist of pure wool or silk. Wet clothes and blankets are a protect- ion by the cooling caused by the evaporation of the water, but only so long as they are wet. Fire-proof clothing of polished metal is founded upon a completely new principle. The very thin layer of aluminum spread on cloth or paper, reflects 80 to 90 per cent of the radiation striking it, prevents an adherence of sparks by its smoothness, automatically protects the upper garments, and is to be developed into protective clothing against mustard gas for civilians, by order of the Inspector of the 13th Air Group Command. Comparative experiments before a burning barn with an air temperature of 14 C, degrees and a radiation of 5 - 10C( produced by a wood fire of 6 - 800 C. degrees over a large surface at a distance of 3 meters had the folio ing effect: A man, without protective clothing, with steel helmet and respirator, retires immediately; a man covered with a wet blanket, after 18 minutes the blanket is charred in front, the man very much exhausted. A man clothed in th; asbestos suit of the fire brigade: temperature on the out- side of the asbestos suit more than 180 C. degrees after 28 minutes, on the upper garments 90 C, degrees, the man very much exhausted. A man dressed in clothes with a coat of aluminum foil (0.008 millimeter) on parachute silk: temperature on the outer surface 54 C. degrees after 28 minutes, on the clothing 32 C. degrees, the man quite fresh; pieces of leather and cloth are charred, the glasses of the gasmask are bent. 2# Death from exposure to excessive heat. Oberstabsarzt (Major. MC.) Prof. PONSOLD The temperatures causing death from exposure to heat begin at 50 C. degrees at which point the skin is blistered, and at 60 C. degrees necroses occur. Effects of heat on the hair are to be recognized from about 150 C. degrees onward, particularly about 200 C. degrees. It consists in discolor- ation, curling, brittleness, and dilatation of the air slit. The hair is not suitable for a differentiation of vital or postmortem changes. In order to ascertain coagulation of the blood the con- dition of the blood of the right ventricle of the heart must be examined by using the hematocrit. The routes of entrance and exit of the heart are to be closed up carefully during the examiantlon. Effects of heat on the respiratory Passages• Prof. A. FOERSTER The speaker reports on changes of the mucous membrane of the trachea which he observed with bur*t persons. The microscopic examination of the epithelial cells showed swell- ing of the epithelium such as may be found at the place where the electric current enters. These changes must therefore result from the inhalation of overheated air. The experi- ments made in this resnect proved the assumption. For this purpose oxygen and hydrogen were exploded, and at the same time a fire was produced by the explosive substance# Thus overheated air developed which was inhaled by the animals# This caused the changes of the epithelium of the mucous mem- brane of the trachea, or a fixation of the cells by coagulat- ion of the plasma. This observation certainly is of import- ance in the large scale air raids, for in this case too ex- plosions occur which cause fires, and in this case too over- heated air develops which men are obliged to inhale# It must be assumed, therefore, that during large scale air raids, be- sides poisoning by carbon monoxyde and laceration of the lungs, inhalation of overheated air also plays a Dart in certain cases. 4. Death from burning. K. H. ZINCK Findings* of recent and earlier dates are shown by de- monstration of fine tissues of burnt and scalded persons. Also, according to the new material of research of ZINCK, there occurs in connection with the burning a primary attack on the vascular system, which becomes pervious to blood plas- ma containing albumin and leads thus to a loss of plasma wit * coagulation of the blood, and finally to collapse. In the organs obviously depending upon function (R0ES8LE), serous inflammation may occur, which, with large parenchymal losses, may cause injuries to the organs that may have fatal results. In early cases the intense edema of the brain with a hyperemia and a corresponding increase of the pressure in the brain are the cause of death. The adrenal gland has no central position with regard to a primary attack by poisons of albuminous disintegration. It may, however, be exhausted functionally, just as the basophilic portion of the hypo- physis may become fairly empty and edematous in the case of death by burning. In the case of hepatic and renal involvement death oc- curs not rarely with the clinical picture of hepato-renal Disturbances of function pass over into an- atomical injuries with burning. The morphological examinat- ion reveals which areas have been affected first and the nature of the attack. With extensive injuries of the organs a-secondary additional endogenous disintegration of albumin- ous poisoning follows upon the primary one (vicious circle). In early cases attention is to be paid to; 1. Brain (edema and hyperemia); 2. Liver (cloudy swelling, dissociation, necroses); 3. Kidneys (necrotic neohropathy, calcification, hyaline degeneration); 4. Heart and vessels (erythrocytorrhexis, hyaline fibrinballs); 5. Blood (fixation Carnoy and Formalin). In late cases: 1. Liver and kidneys, 2. Heart and blood vessels, 3. Brain (ganglion cells), 4. Hypophysis and suprarenal glands (basophilia). 5_. Effect of fire-storm on the human body. Qberfeldarzt (Lt. Col.. MC.) of the Police KRAEFFT The observation given in the preceding reports concern- ing the injuries to heart and causes of death during fires over large surfaces are confirmed. The opinion expressed by- laymen that a deficiency of oxygen near large fires has led to death in many cases, is disproved by the fact that any defic- iency of oxygen should lead necessarily to an accumulation of carbonic acid and that the poisoning by carbonic acid should be one of the prevailing phenomena. This fact, however, could in no case be proved to be the cause of death. Discussion following the lectures on death from exposure to excessive heat and burning• FOERSTER: The same changes can be produced in the lungs postmortem though only in the area where the effect of heat took place, BUETTNER: Concerning the question of the inhalation of hot air, the following personal observation by the author at 200 - 250 C, degrees shall be mentioned. The sensation on the face is very disagreeable, injuries do not occur probably on account of the already present supply of sweat, except one burn at the spot where the spectacles, covered with an insul- ating substance, rested. The respiration was not rendered disagreeable nor any more difficult, except that the heat bad- ly affected the edges of the nose. A curve of the time for which the heat can be tolerated ("Hitzefluchtzeit") is shown, that is to say for that period during which the complete physical and mental capability of action is still more or less unimpaired dependent on the effects of the temperature of the surrounding area. The curve is based on observations between 50° C. and 250° C. and on calculations based on the following facts; the required capacity for action decreases, if the body temperature and the temperature of the skin continue to increase correspond- ingly, and if the body temperature has increased at least one degree as compared to the temperature at the starting point. Moreover the apparently highest possible peripheral blood supply and the normal development of the warmth of the body and clothing are assumed. The time for which that can be tolerated is e.g, for 50° C. - 3 hours, ?0° C. - 1 hour, 130° C. - 15 minutes, and 250° C. - 3 minutes. BUHTZ: Reference is made to the vital and postmortem changes by the effect of heat, to the need for exact quantit- ative spectroscopic and spectral photometric examinations (LOEWE-SCHUMM, KOENIG-MARTENS). Cerebral sclerosis with ne- crotic hematoma caused by negative pressure in the cranial cavity and vacuum are to be considered as postmortem phenomena. In the case of cracks in the skull caused by the effect of heat, it is often wrongly attributed to a blow inflicted with a blunt instrument. OSTERTAG: If there are no well-known assumptions based on experiment, the number of unknown factors is so great that an indisputable determination of the cause of death is im- possible. The rapid postmortem changes make a solution of the problem difficult. In unusual cases one must try to find out what materials had been stored in the buildings, which of all these materi- als were thus changed by the effect of heat, fire, or water, so that a fatal effect may have been produced early. Death by carbonic acid is certainly not sufficiently taken into consideration, just as little as the effect of gas from de- fective sewers. For an explanation of all these ouestions it is there- fore necessary: 1. To take into consideration the clinical observation of those who have survived, 2. To ascertain exactly the local conditions, 3. To carry out the postmortem examination as soon as possible. MUELLER: The bloating of the dead body probably takes place by the formation of vapor. After the decrease of tem- perature or after the bursting of a body cavity the bloating decreases. AMMICH; The frequent very impressive cerebral edema occurring rapidly, and leading to sudden death, may also be- come intense and may be of long duration without becoming the immediate cause of death. A case out of my own practice, of a burn of the abdominal walls by the explosion of a hand gre- nade, with subsequent death as a result of fecal peritonitis, 2i days after the accident, with most serious cerebral edema, signs of cerebral pressure and hyperemia of the leptomeninges is mentioned. In this case symptoms of a central cerebral death were not present. GHAEFP: A small number of deaths in the fire-storm can probably be explained as immediate death by burning. The question, as to whether death by deficiency of oxygen is really possible I leave open. For the vast majority of death exposure to excessive heat must probably be regarded as the cause of death. Numerous reports registered by me of the experiences of persons escaped from fire-storm showed that part of them had perspired freely and had quenched their thirst as soon as possible with any kind of water, while the other part has neither perspired nor had they afterwards felt particularly thirsty. This fact makes one suppose an in- fluence upon the heat center (mid-brain) and indicates with this kind of fatality that death resulted from heat in the manner of heat stroke. Also the quick recovery of those saved without any secondary symptoms (no headaches as there are after poisoning by CO) points in this direction. Directions on death caused by exposure to excessive heat and burning. 1. Blisters (size and position). a. This sign is only of value if there are no blisters caused by decomposition. b. On the dead body, however, blisters may form, but in this case, these are gas blisters. If they contain liquid, leucocytes are absent, 2. Vascular marks. The corium tightly filled with detached epidermis in consequence of a coagulation of blood accumulated by hyperemia due to excessive heat. This phenomenon does not concern the dependent parts of the dead body, since in them the blood vessels are filled by hypostasis (within the livid spots). 3• CO - hemoglobin in the blood of the heart• This finding has value only when the quantity of CO - hemoglobin is below 50 per cent. With higher quantities of CO - hemoglobin death may be caused by CO - poisonings. There- fore, the quantity of CO - hemoglobin should be ascertained. The blood should be transmitted in small hermetically closed ampules, filled up to the brim. 4• Soot in the trachea and in its smaller ramifications. This phenomenon is of value only if it occurs during the burning and not before it e.g. smoke (soot) has been inhaled if during the attempt to escape from the flames. 5. Soot in the stomach• Objection as under Mr. 4. 6• Fascicular arrangement of the bronchial epithelium between the honeycombed blisters caused by heat• This is a phenomenon caused by heat, since the respirat- ory passages are protected and "honeycombs" develop as a rule only by inhalation of superheated air. 7. Fat embolism in the lungs. Points to a trauma or scalding. 8. Local effect on blood vessels. ?/ith burnings and scaldings which have been survived for a short time, a serious injury of the vessels occurs by a prob- able "resorption of poison". Even within a few hours histo- logical changes of the organs are found. Early death is most- ly caused by cerebral edema (increase of cerebral pressure), in some cases a single injury of the organs may be fatal (e.g. serous myocarditis). 137 6. Death caused by dust. Stabsarzt (Captain. MC.) DESAGA The fatal conditions of suffocation by inhalation of dense concentrations of dust are discussed. Suffocation by dust during an air raid is very seldom observed to be fatal. The original report is published elsewhere and may be ob- tained from the Aviation Medical Research Institute of the National Air Ministry (Luftfahrtmedizinisches Forschungs- institut des RDM, Berlin). Discussion: BAADER: When the aircraft disaster occurred in Antwerp I was some hours later at the spot where it had happened. The corpses were thickly covered with dust. The children who were found still alive had been protected by the skirt of a nun, like chickens covered by a hen; but soon after- wards they died too. HOESSLE: Death by dust is referred to in which case the larynx and the whole trachea were filled with gray soft mucous mortar, probably inhaled dust, soaked in edema. In these cases the mass should be gathered and weighed in moist and dry condition in order to ascertain in what ouantities it becomes fatal to man. BHEITENECKEH: In the Vienna Institute for Forensic Me- dicine a case of death by dust was observed some years ago, which occurre(j vdien a coal miner, against the regulations, advanced to a coal slide and looked up in order to see ■•hethe] the coal car was discharged at the upner end of the slide and the coal rushed down, raising an enormous cloud of coal dust. The miner afterwards was found suffocated by coal dust. In this case one could speak, therefore, of death caused by dust. 7. Carbon monoxide poisoning and detection of CO• Oberfeldarzt (Lt. Col.. MC.) Prof, LAITCHE The causes of fatal CO poisoning among soldiers• A report is given on the evaluation of the reports by the sections of army pathologists concerning fatal but unintent- ional CO poisoning (that is to say excluding suicides) based on the material of the Report Collecting Station controlled by the Consulting Pathologist of the Military Medical Inspection Service. The tables shown are based on the evaluation of the reports made by U. A. DOEHNER. They are intended to give a survey of the causes of CO poisoning, therefore, the comparat- ive numbers were given without calculation of any average values. There were poisonings by: I. Illuminating gas, 34 per cent; II* Charcoal fumes, 37 per cent; III* Motor exhaust gases, 14 per cent; and by unexplained and other rare causes, 15 per cent of unintent- ional deaths by COt Ad. X. Most frequent are deaths causes by irregularities in the operation of gas water heaters (20.5 per cent; and through carelessness (2.3 Per cent), defective waste-pipes for the combustion gas (8.2 per cent), defective stoves (1.2 per cent), and unexplained primary causes (8.8 per cent). 5.3 per cent of the accidents were caused by gas heating stoves, 0.6 per cent by gas cooking stoves. 3*6 Per cent' by 'open'"gas 1.8 per cent by defective gas pipes, and 0,6 Per cent'the bursting of gas pipes underground. Ad. II. The "charcoal fumes" (poisoning by smoke fumes) mostly developed from stoves operated in a faulty manner (16.4 per cent), also from fires outside the stove (4.7~Per "cent), which mostly on account of drunkenness, were not detected in time. Burning of the bed when smoking in bed (in most cases also under the_,_influence of alcohol), was found to be the cause in 1.2 per cent of the cases, «. . The full particulars could not be ascertained in 15.2 per cent of the cases. Ad. III. Poisoning by motor exhaust gas was due to the very common bad habit of letting the motor run 1) in closed rooms (2.4 per cent). 2) in the open air, but with the car closed (6.0 per cent). In 4.1 per cent of the cases death was caused by the escape of gases containing CO into the car through leaking exhaust pipes. Unknown as regards particulars remained 2.4 per cent. The causes were the same as those known to doctors in peace-time, lack of thought or carelessness and drunkenness often playing an important part. A decrease of accidents is to be attained only by continuous instruction as to the imminent dangers and severe punishment for the non-observance of the regulations. Causes which were characteristic for the Armed Forces and would require new regulations could not be found. New pathological anatomical observations worth mentioning, were not made. B_* . Poisoning by carbonic monoxide. zt__.CMalpri MC.) Prof, BUHTZ Poisonous substances; a. Gas from fire, b. Illuminating gas, c. Technical gases containing CO, d• Poisonings by several substances (GO * C02, CO + nitrose gases). Since the known clinical and pathologic-anatomical change., due to acute poisoning by carbon monoxide afford no proof but only an indication, the objective nroof must be adduced in sur- viving cases, particularly, however, in rapidly fatal cases of CO-poisonings’ 1. By reconstruction of the circumstances (particularly examination of the place of occurrence), 2. Demonstration of carbon monoxide in the blood by mears of physical or chemical methods (see report by BREITENECKER). As a rule it is only with protracted poisonings by carbcr. monoxide and escaping, that the well-known symmetrical focuses of softening in the lenticular nucleus can be cited as object- ive arguments. Statistics: Accidents were mainly caused by gas from fires and tech- nical gases, a smaller number by illuminating gas. During air raids deaths occurred by gas from fires as well as by illuminating gas (destruction of gas pipes). Murder by illuminating gas was rarely observed, by from fires in some cases. Poisonings by gas from fires were more frequent in the country, poisonings by illuminating gas more frequent in town. The number of cases of poisoning by gas from fires, apart from large scale air raids, varies according to the seasons, corresponding to the heating period. Poisonings by illuminating gas, apart from large scale air raids, on account of the frequency of suicides, vary ac- cording to the seasons, corresponding to the suicides by gener- al poisonings used in the household and in trade. Suicide by illuminating gas is the prevailing method with females* The concentration in corpses with poisoning by illumin- ating gas 21 - 81 per cent, on an average 49.3 per cent, with gas from fires 20 - 80 per cent, on an average 4-3 per cent. With illuminating gas the distribution in the organs is equal, with gas from fires there is a strikingly high percent- age of it in the kidneys. With illuminating gas 99 per cent of the death spots are light red, while with gas from coal fires only 68 per cent are light red. Causes of injuries to health and deaths by Illuminating gas. A. Accident. Defects of pipes caused by air raids, taps and tubes partly opened or leaking. Leaky plugs or connections of gas pipes. Falling off of rubber connecting tubes. Accidental tearing off of the rubber tubes in fainting fits, attacks of vertigo, and other fits. Extinction of the flame caused by draft or boiling over. Extinction of the flame of the water heater, radiator, or gas range. Lowering the flame too much (putting on too large a pot filled with cold water). Absorption of the odorous substances by steam, (bath, sauna) or with poisoning by escaping gas (bursting of gas pipes and others). IB. Suicide. Opening of taps, perhaps combined with taking soporifics. Killing oneself and one’s whole family. Simulated suicide (Simulation of accident). C. Murder. Fictitous suicide. Combination with soporifics and other poisons. Dislocation of gas pipes, of rubber gas tubes which pass through the walls of inhabited rooms. Injuries to health and deaths from gas from coal fire. A. Accident. Gases developed by fires during large scale air raids. Defective or damaged chimneys of heating installations. Defective stoves (Stoves made of Dutch tiles), unsuit- able heating materials, coal. Stove doors closed too soon (wrong manipulation). Stove doors, stove pipes, flues and chimneys defective or not tightly sealed. Choked or closed flues and chimneys• Defective introduction of flues Ihto stoves and chimneys (torn off flues). Faulty installation of stove pipes, flue for the smoke adjacent room, room in the upper floor). Deaths in garages with wood gas generators on autos. Crude coke stove in the bed room. Stove with slow burning fire (joined to normal chimneys). Soot obstructing the draft of the stove and the chimney. Difficulty in venting the smoke gases caused by residual ashes and chimneys blocked by snow. Back pressure of waste gases of a gas hot water heater. Closed damper In stove .pipe. Faultily installed flues, introduction of stove pipes into ventilation ducts. Gas escaping from small leaks. Influence of the weather on the draft of the chimney (defective petroleum stoves). Coke stoves, 'e.g. marmalade tins, in closed rooms (cellar, bunker, in thawing out water supply pipes). Installation of heating stoves in motor cars. Live coals falling out of stoves and setting fire to the room. Hot slag. Fire brigade (salvage). Coal stoves in auxiliary hospital trains, service- and frontleave trains, sauna. Smouldering of combustible material near the stove (wood, clothing, linens)• When kindling fires (with gasoline) the clothes and other substances catch fire. Upsetting of lamps (stable lantern, candles) with spread of fire to surroundings. Smoking in bed (fires in beds), occasionally by hot bricks. Discarding live matches with resultant smouldering fires (burning of rooms). Sleeping close to or on the stove. C. Murder. Stopping up of the flues, coal pans. By charcoal fumes in closed bath rooms (murder of the stepchildren)• Injuries to health and deaths due to technical gases containing CO. A. Accident. Large scale air raids (gases developed by fire), hot slag, poison gases. "Pioneer disease11 of miners (CO), nLimousine disease"• Death In garages (cold air). Heating with exhaust gases, leaky pipes. Suction of exhaust gases. Accumulation of gas in insufficiently ventilated rooms. Driver Ts seat of trucks propelled by gas produced..from wood. "Maultier", (poor venting of the exhaust gases). Tunnels. B. Suicide. Dissimulated suicide in garages. C. Murder. Preparation and administration of CO from formic acid HCOOH by the action of H2S04. Murder in garages. Concurrent causes of death. Natural death, poisoning by alcohol, soporifics, C02, CH4, death caused by excessive heat, lack of oxygen. 1- Recognition of polsonings s a. acute b. chronic (exhaustion, headaches). Exact clinical examination of the blood. 2. Erroneous diagnosis of poisoning. Most frequent when caused by illuminating gas and gas from coal fire. Confusion with poisoning by foodstuff and by ficporifics. Causes of mistakes. False history (careless, intentional, to protect crim- inals). No history in case of death or unconsciousness. No inspection of the place where crime was comnitted (often re- luctance of the physician to inspect the place where crime was committed; with heating installation, test heating). No proper postmortem examination of the body (light red death spots over- looked* since the body was not undressed). T'rhen gas from coal fire is the cause, often no or only a few light red death spots. No blood tests sent in (blood samples not to be taken from vessels near the surface on account of a danger of diffusion from atmosphere containing CO). Blood must be taken immediately from the survivors, since otherwise the test becomes more dif- ficult on account of the subsequent secretion. There must be no pre.iusticel I The examination must be made without prejustice and everything must be considered. Examination of the place where the crime was committed (cause, tests of air! Poisoning by carbon toonoxide is often not sus- pected, because no odor was observed on account of a. strong dilution, b. filtering off of the odor in case of escaping gases, c. absorption of the odor by steam, d. soporifics, e. intoxication by alcohol, f. unconsciousness. Prophylaxis. a. Proper heating installations and supervision is imperative especially at the beginning of the heating season. (Bunker, Panje cottages, etc.). b. Proper attention to the fire (instruction con- cerning the method of heating and the kind of fuel). c. General instruction concerning the dangers (par- ticularly at the beginning of the heating season). The bunker must be left in time during air raids (canary). Testing for carbon monoxide. Dozent BREITENECKER After a survey of the methods of testing for CO in the air the use of salts of palladium, gold and silver, by the oxides of manganese, copper, mercury, cobalt, silver and chromium or mixtures of these, particularly by iodine pentoxide and the filters of gas masks constructed according to these processes as CO-gas detector apparatuses and CO-measuring apparatuses of the "Draeger Werke”, in the "Auergesellsbhaft" and others, the question of ascertaining the content of CO in the blood was discussed. The Qualitative testing is done best by means of spectro- scopic examination, for which purpose a hand-spectroscope is quite sufficient. Sodium hydro sulfate (Na2S204) is recommend ed as a reducing agent which acts more quickly, and which is solid and more stable than ammonium sulfide, such as is laid down in Army Manual 396, Navy Service Manual 318, and German Air Force Service Manual 96. The lower limit of detection by this method is about 20 per cent of CO-heraoglobin. But less than 40 per cent of CO-hemoglobin must be ascertained by the quantitative method. The quantitative proof can be carried out by means of the gas-analytical or physical method. Among the former methods the best seems to be the iodine pentoxide method (MAY, FISCHIN- GER, SCHMIDT). Among the physical methods we mention the spectrometric, the colorimetric, the comparison photometric, the spectral photometric, and the infrared photometric method. Among these the methods of MAY, RANKE, and SEYDEL with the comparison photometric apparatus are to be recommended for prophylactic examinations, or the examination of survivors, while the spectral-photometric method is suitable for the ex- amination of blood of every kind, from the living person or the dead body even in case decay has set in or there has been part- ial combustion of the body. Therefore, this method is recomraec ed first and foremost, particularly, as only a few drops of blood are sufficient for an examination and the control takes only 5 minutes. These methods are adequate down to a lower limit of about 2 per cent. Smaller quantities must be ascer- tained by gas-analysis but they are irrelevant to our question. If there are survivors, it is important that their blood should be taken then and there, and sent in for examination, with an accompanying letter giving particulars of the poison- ing, stating when the person concerned was found, and the blood taken, also mentioning symptoms of the disease. In the blood taken or in extravasations, CO can be ascertained for a long time, in the circulating blood it is quickly excreted by the respiration (on an average after 10 hours). In corpses CO can be ascertained even after months have elapsed. The blood should be without admixture of any substance and should be placed in small tubes, brimful1 and closed tightly. With be- ginning decay, the stopper must be fastened so that it cannot be blown out by the gases of decomposition. In conclusion it is pointed out that it is possible to diagnose CO-poisoning from the pathologic-anatomic findings, even when the dead person has survived the poisoning for more than 10 hours so that the CO has been excreted again from the body, except for such small quantities that they are difficult to demonstrate. Discussion about the reports concerning poisoning by carbon monoxide and the proofs of the presence of carbon monoxide in the body• GRAEFF: The value of the quantitative determination of CO-hemoglobin in corpses shrunk by combustion after bombard- ment is frustrated by the fact that with these corpses the local heating of the organs makes it possible to demonstrate CO, or because the hemoglobin is destroyed by putrefaction. BUHTZ: Vrith corpses which have been in the CO-atmosphere for a comparatively long time, the taking of blood from deep lying vessels (cavity of the brain) is required, because of the possibility of postmortem diffusion. In case of mass-poisonings blood tests must be made im- mediately and marked separately with the names of the person's concerned. In case of mass-poisonings In the same room the most widely variable percentages of CO were found. „ micro-spectroscopic method, the microscopy according t© LOEWE-SCHUMM gives valuable results only down to 20 per cent. Smaller quantities below 20 per cent may be as- certained spectrometrically by means of the apparatus of KOENIG-MAHTENS. Decreased oxygen plus CO2 must be considered in the dif- ferential diagnosis. BAADER: In bunkers of the "Atlantic Wall" ("Atlantic Fortification") furnished with iron patent stoves, poisoning by CO (among them some fatal cases) were observed, though the stoves were being attended according to the instructions. r he flue for the gases of the stoves is connected direct with the hand-grenade pit of the bunker. Control tests have shown that if the wind is in the direction of the hand-grenade pit, the waste gases of the stove are blown back into the bunker. MUELLER: In northern Russia and in the Eastern territory a poisoning by CO does not occur with wood heating, even when the stove-register is closed” it does, however, occur, when coal or coal mixed with wood is exceptionally used and Then the stove damper is closed too soon. WIETHOLD: Report on cases of poisoning CO in the open air and in bomb-proof shelters, the latter by pumping air con- taining CO into the bombproof shelter. Remarks concerning the estimation of CO in the blood. FLUKY: In case of poisoning by mixtures of CO (gases developed by fires, exhaust gases, .emoke) the percentage of oxygen in the air mixtures plays an important part. Lack of oxygen increases the CO danger to a high degree, while the admixture of COp is of little importance as gas which furthers the respiration; (Recent investigations by 0. KLIMMER, Wuerz- burg). Directions regarding poisoning bv carbon monoxide. 1. When measures ate taken immediately samples are to be taken at random from corpses in various rooms. 2. Blood from deep-seated vessels (heart, meningeal sinurs, kidheys, pelvis;, or extravasated blood, bloody liquid or pieces of tissue filled with blood are to be sent in for the purpose of quantitative proof of CO. Organs too much boiled, or roasted, or carbonized, are useless. Of juveniles also the hollow cylindrical bones are to be sent in. 3. The tubes must be filled up to the brim, with the test material (blood etc.) and must be closed tight (cork or rubber stopper). 4. The nearest test institute or auxiliary test in- stitute must be well-known to the chief of the research group for the ascertainment of doubtful causes of death during air raids. 5. With survivors blood must be taken as soon as they are found, because of the rapid excretion of the G0# 6. Information must be given to the competent examinat- ion department about the place where bodies were found and, if possible, an anamnesis Including a sketch of the place where the accident took place. 7. For quantitative CO test any practical physical method available is useful. 8. Statements should be made about the result of the de- termination of CO in the blood or the percentage of CO-hemo- globin. Statements of cubic centimeters in the blood should be avoided, they must be converted into per cents of CO-hemo- globin. The results of the experiment must be given to the chief of the research party. 10. Self-inflicted Injuries* Qberstabsarzt (Manor, MC.) Prof.#_iOELIJ)H If a soldier intentionally injures himself so as to shirk duty, this is a case of self-mutilation. If he injures himself through negligence, it is to be called mutilation through ne- gligence* The cases of mutilation through negligence are hand] ed In the following manner: The army surgeons, the physicians at the main dressing stations, and the physicians at the hospit- als send every case of unaccountable injury, in which self- mutilation may be a consideration, to a hospital where a con- sultant in forensic medicine is attached. By including so mam- men for examination to detect the real cases of self-mutilation, the examination of many innocent men is inevitable# Any defam- ation of the soldiers to be examined is, therefore, avoided# During the examination attention is first paid to in juries caused by close-range shots. Burnings are practically out of the question with close-range shots from^modern weapons, just as is the presence of particles of powder in the wound# Near the spot where the bullet entered the textile fabric is sometimes roughened and of lighter color with close-range shot from a distance up to 10 centimeters# In this case it is the question of a loosening of the fabric by gas pressure# Its presence is a sign of a close-range shot and besides^this a sign that a flat trajectory weapon was used# Tears in the text lie fabric are found with shots from small arms up to 12 centi- meters# The skin breaks at a distance of up to 2 centimeters# A gunshot wound where the skin is broken is an important sign of a close-range shot when a breaking of the skin by a fracture caused by a bullet is out of the question. The most important sign of a close-range shot is the edge caused by the smoke of the powder which can usually be diagnosed macroscopically# li a macroscopic diagnosis is not possible because the shot was fired at comparatively close range or if the textile fabric is soaked with blood, the examination must be made by means of "Dithizon" reaction# A microscopic diagnosis of the powder smoke is very difficult. According to the speaker, it is just- ified only in exceptional cases. The edge of powder smoke must not be mistaken for an edge caused by grazing or by dirt# If the hand of the soldier was dirty, the secretion of the wound, the blood, and the dirt combine to a blackish crust which may be mistaken for powder smoke# Russian explosive cartridges do not generally cause phenomena which could be mis- taken for signs of close-range shots. There is, however, one exception, namely if the hand of a soldier was just touching wood. The explosive incendiary cartridge penetrates the hand without detonation. It detonates only in the wood. The powder smoke is at the spot where the bullet leaves the hanj# The particles of the bullet are not in the hand, but in the wood. According to current opinion tracer incendiary qgjwtr do not cause noticeable changes at the spot where the bullet enters the body. Spent tracer cartridges cause a lining of the channel with smoke. Two experiences in practical cases, however, raise the question, whether for once a tracer cartridge may not leave a trace of smoke around the spot where the bullet entered. Special examinations are going on. In case of filter shots a diagnosis is easy if the filter- ing object is found (folded handkerchief, "Hindenburglicht”, bread, trunk of a tree). Otherwise diagnosis is only possible if traces of the filtering object can be proved macroscopically or microscopically at the spot where the bullet entered the body, which was sometimes done successfully. If a soldier asserts that the wound was caused by a long- range shot, while it was actually due to a close-range shot a self-mutilation must be suspected. Recently, however, the cas- es increase in which soldiers, who are mentally normal at first pretend that they were ivounded by a long-range shot, though the wounds are due to careless self-mutilation through negligence. In the instructions on self-mutilation sometimes a sharp dis- tinction is made between self-mutilation and mutilation by ne- gligence. By this soldiers are sometimes frightened and at first tell foolish lies. Such.conduct can now no more be re- garded as positive circumstancial proof of self-mutilation. The descriptions of the accidents must be demonstrated and put down carefully in writing. After that inquiries at the unit must be made. If a self-mutilation is to be suspected th case is submitted to the military court. If it can be proved that the soldier is found not guilty the unit is informed of it A copy of the findings is added to the medical report in order to prevent a resumption of the cases by another hospital. The results of the proceedings at law are sometimes diffi- cult to foresee, since the military administration of the law is somewhat unstable. Generally the judges examine the cir- cumstances very carefully. Sometimes there are surprising ac- quittals, particularly if the defendant makes a good impression and bears a good character. Therefore, the soldier had best make a confession in the course of the trial. Although it is not the special task of the medical expert to obtain confess* • ions, hewilT be bound in duty to put down in writing the con- fession immediately if it is made spontaneously, and to avoid suggestive questions during the examination. Otherwise he risks a later disavowal of the confession. The self-mutilators may be divided into two groups. Some of them commit the deed in a fit of emotion (bad news from home, severe enemy attacks, death of comrades). They make no prepar- ations for later excuses and soon confess everything. The sec- ond group consists mostly of veteran^soldiers who are weary of the war. They make cunning preparations, think out elaborate excuses and are usually found out only by chance. The number of self-mutilations has increased only moderate- ly since the appointment of consulting medical officers for forensic medicine. Their greater increase in the beginning is to be accounted for by the fact that the organization of the methods of detection was improved considerably later on. Self- inflicted injuries through negligence constitute a large pro- portion of the total number of examinations. Among these genu- ine cases of self-mutilation are hidden which cannot be proved with sufficient certainty. A discussion of this question is suggested; whether the possibility of legal punishment for mut- ilations through negligence should be obtained by a change of the laws. To differentiate between a deed committed deliberate- ly and one committed through negligence is rather difficult. Disciplinary punishments are not always sufficiently severe. 11# Chemo-technical examinations as a means to prove Stabsapotheker (Captain, Pharmacy Corps) MAYER A report is given on the steps of analytical examination in proving chmical artefacts. The analytical course was work- ed out in the Institute for Military Pharmacy and Practical Chemistry of the Army Medical Academy, Forensic-Chemical Sect ion* In the wound crusts of cauterized animals cauterization agents could be proved commonly after 1-2 weeks. In order to prevent contaminations of the examination material, it is recommended that the specimen be sent in the state in which it is has been excised, instead of preserving it. In the second part of the report the chemical methods for ascertaining close-range shots were critically examined. The ascertaining of lead by means of "Dithizon" as the only chemical proof of a close-range shot is considered to be in- sufficient and as too little characteristic. The spectral- analysis, by means of which all elements (substances) of a close-range shot can be proved objectively and accurately is described. As elements of a close-range shot all metals characteristic of a close-range shot are to be regarded. They are chiefly the metals of the detonator such as lead, anti- mony, barium, zinc, and tin. By moans of the spectral analys- is the powder smoke of close-range shots can be distinguished from the powder smoke of tracer and incendiary ammunition which is due to long-range shots. Spectral analysis is recommended as means of securing the most exact proof of a close-range shot. 12. Malingering. Oberfeldarzt (Lt. Col.r MC.) Prof. BAADER Malingering presupposes two things: firm will and skill of the malingerer and credulity and ignorance on the part of the physician. By the leaflets of the enemy propaganda (e.g. the so-called sporting-regulations for the Navy) the enemy tries cunningly to suggest to the soldier how he can most suc- cessfully simulate a disease. Just as the management of arms and the propaganda of modern war has been very much perfected. also the equipment of the malingerer has improved and, there- fore, the physician must know these improved rules of the game of malingerers, the speaker explained. The hopes raised in the malingerer on the part of the enemy propaganda by the sen' ence: ’’The symptoms you find described in this leaflet are selected in a way that no physician can ever find out that yen. are really not suffering from this complaint, or that you haV’ caused it by artificial means’*, are absolutely delusive. As- pirants of the medical corps examined the enemy advice in the4 theses of their own accord and proved that the instructions of the enemy propaganda for the production of paralyses of the e: tremities, simulation of epilepsy, etc. were altogether too difficult and required too much talent for acting. In the 33 hospitals of the area of the speaker, though special heed was given to the subject, not a single case of production of one of the diseases recommended in the leaflets has been observed. The few simulations of any disease the speaker had seen with: ) a year (self-poisoning by thallium, hemmorrhage of the intest- ines produced by artificial means by introducing a knitting needle into the rectum) were done by methods which are not contained in the sporting instructions. The speaker also made a survey of the simulations of infectious diseases of the dif- ferent organic systems. Most frequent are the simulated dis- eases of the stomach about which he was several times consult- ed as expert by military courts. Most of them (the simulators) were members of the ’’Volksliste 3"* (Volksliste 3 was a roster of individuals who did not desire do adopt German citizenship.) Discussion on the reports concerning self-mutilation rnd malingering. BUHTZ: Of the cases of self-mutilation on which an opin- ion was given by myself, about half proved to be suspected wrongly (accident caused by arms or of some other kind, caused by the enemy, disease). In the field most cases concern gun- shot wounds in all the limbs and parts of the body, chiefly on the left side, while in the home area cauterization and in- jections, e.g. of petroleum are more frequent. Intentional breaking up of artificial teeth and spectacles was likewise observed. The method of examination is described; a report is given on a new method worked out in collaboration with WOLKE- WITZ and very useful in the field for proving gunshot wounds by tracer ammunition (imbedding of glycerine-gelatin with form- ation of barium sulfate crystals. He further discusses the method of proving or ascertaining whether injuries were caused by explosive shells or hand grenades. Measures for the pre- vention of self-mutilations are discussed. The number of self-mutilations is steadily decreasing and is strikingly small as compared with those in the World Wdr I (1914/1918). This fact is due chiefly to the national polit- ical training of the masses. HANDKB: In Breslau many cases of petroleum injections were examined. Determination by an analytic method is similar to that given above (combination of hydrolysis, fractional distillation of steam, fluorescence and solubility of organic dyestuffs). As for the persistence or the traceability of petroleum and similar substances it has been ascertained by experiments that after four weeks proof is hardly possible. According to the literature on the subject, hydrocarbons do not penetrate the skin. This proves true for vaseline as roll as for petroleum# Experiments have corroborated this. LUXEMBURGER; The swallowing of black powder is said toot to bring about fever but a general feeling sick and ill. com- bined with paleness, perspiration and singultus. Thus the pretended disease is to be made more credible. JUNGMICHEL: The well-known "Sporting Directions" are no- dropped from airplanes France in the form of cigarette paper packings called "Gizeh". However, I do not consider these directions to be very dangerous. They are too "subtle" for the simple nan* The in- telligent soldier who intends to commit self-mutilation choos es other means, because he realizes, that the German medical officer knows these Sporting Directions so that he is bound t< be found out pretty soon. As for the rest, I would say that on the western front a centralized examination place for self-mutilations has hither- to been unnecessary, because such cases were and are still wr few and far between, owing to the special circumstances. The proportion of suicides among outo troops on the western front is smaller than that among the male population in peacetime in Germany. 13. Psychiatrist expert opinion on self-mutilation and on neglect of duty when on guard, Oberstabsarzt (Major* MC.) VJ. von BAEYER These statements about self-mutilation arc based on 32 personal observations by the author, 16 of v’hich were cases in which his expert opinion had been asked while 16 concerned ex- aminations of culprits in a surgical ward which were picket at random. Some of the culprits (12) had shortly before come to the front from the home area or from the hospital. The major- ity are young, even very young, soldiers. (22 delinaucnts from 1? to 25 years old). Apart from an officer who had sus- tained a concussion of the brain? all the other culprits were below the rank of corporal, soldiers of the rank of corporal were lacking. Nine of the culprits were previously convicted by military or civil tribunals, most of them had been previous- ly convicted and were judged unfavorable by their superiors. Characteristically the culprits do not^offer a uniform picture, the majority, however, are weak, timid, unscable, un- steady, and irresolute men. Some of them were decidedly irrit- able, unstable in their moods, or desired^to be regarded as im- portant fellows, some impressed one as auite infantile without being abnormal in any other way. Imbecility of' a sTight or medi- um degree was often found, above all among the cases I had to give expert opinion on (8 of 16). An attempted suicide, and that a non-energetic one, occurs only once in the records of the antecedents. Most of the self-mutilators arc bad soldiers; as regards their civil and social conduct, however, they arc harmless, weak, slack men. Among the emotions, fear and anxiety about their life are predominant, though this was very rarely frankly confessed. Some of the culprits declare,, they wanted only to have a rest for some days. Heal states of exhaustion before the deed could not be proved in any case. In some cases credible statements were obtained on difficulties of getting into touch nth com- rades and disagreements with superiors and comrades, particul- arly, when the soldiers had come recentl}'- from the former Pol- ish areas of the Reich which were only recently incorporated. These people often had difficulties in making themselves under- stood and are not infrequently made game of by their comrades. Altogether one gets the impression that such difficulties furn- ish the chief motives fc> the deed. It is, no doubt, good com- radship which prevents the individual soldier from making such desparate attempts at evading his duty. An understanding psych- ological judgement of the motives of the deed is not always oasy, it is, however, essential for the juridical decision. Strongly marked abnormal reactions arc less important than might be supposed. A twilight state or other exceptional state of psychopathic nature was not present in any case. Four cases came very near to it, depression on account of homesickness, reactive depression for other reasons, a particularly intense state of anxiety when under fire, and a protected reaction which may be considered as abnormal conduct. 153 Among the cases on which I had to give expert opinion there were 2 Psychoses? One man injured himself in the beginn- ing of a helplessly paranoid schiziphronosis, another one in a state of epileptic twilight between two fits. In the case of an officer who had a small splinter sticking in the‘left part of the fore-brain which had not been noticed before, the deed Fas to be considered as a reaction due to an organic injury. The consumption of alcohol is not decisive in any of these cas- es, as it is in other cases of military delinquencies. Exoneration took place only in the two cases of psychosis and in the case of which the reaction was due to some organic injury, also according to § 51, section 2, combined with § 42b in the case of an asocial, imbecile soldier unfit for military service. Extenuating circumstances were often stressed as to whether a case is ,!less severe”• The decisions, however, must be left to the court. Among cases of negligence while on guard duty, only care- less falling asleep while on guard duty is discussed in detail. Continous lack of sleep and the heavy strain of guard duty on the soldier in the main defensive line is to bo taken into con- sideration, above all the lack of recuperation caused by the frequent interruption of sleep and the monotony of guard duty at night. There are, iaoreover, great individual differences in the desire for sleep, according to constitution and disposition. Causes of an increased desire for sleep are e.g.J bodily and mental infantilism, inability to sleep, men suffering from vege- tative dystonia (SCHULTE), weakening by infection and disturb- ances of the circulation. Some people fall asleep abnormally easily in an unattractive environment, though they are not act- ually tired. Also with the perfectly healthy person there is a limit to the "ability to keep awake” which cannot be overstepped in spite of the best intentions and the greatest energy. If, In case of a soldier who sleeps on guard duty, - after considering all external and internal circumstances, to which also belongs examination by an internist - it may be assumed that the limit of the ability to keep awake was reached, the careless falling asleep is to be denied when no psychical or organic disturbances of the brain can be demonstrated. The ability to keep awake, however, under given conditions always depends on the personal attitude and intention. The question as to the sound state of mind (full account- ability) arises in case of sleepers on guard duty: 1. if the resistance to natural desire for sleeping, due to psychotic disturbances or imbecility is suspended or reduced, 2. if the sleep itself is not physiological but is really a disturbance of conciousness due to brain-disease. This is the x>ase above all with narcolepsy. Soldiers suffering from nar- colepsy do certainly often sleep on guard duty. They are, how- ever, seldom brought to trial, since the morbidity of their fits of sleep, combined with the effective loss of tonus is usually recognized in time, and moreover the patients often are decent and conscientious men and are not believed^capable of any negligence. They are, of course, not responsible for their falling asleep on guard duty. 154 Discussion: CHRISTUKAT: It is not possible to give reliable figures as to the total extent of self-mutilation, since the criminal statistics of war in their present form do not give information on this subject* Nor is the age of the culprits to be recog- nized which would be important for criminal biology. Even the relatively low figures given by Herrn von BAEYEI; will show that from the point of view of criminal psychology various latent phenomena may be suspected in cases of self- mutilation. Therefore, it seems to be advisable to get the expert opinion of a psychiatrist, if possible for a proper judgement. KLIMKE: Emphasizes the need of getting the expert opinion of a psychiatrist, above all in order to eliminate cases of a morbid character. and toxicologic questions of general and special character. Professor TIMM The forensic proof of poison is based on the medical find- ings in the body of a living person or in a corpse, as well as on chemical proof of poison. In the course of the last decade the methods of research and the identification of poisons have been extraordinarily im- proved, owing to the development of microchemistry and micro- determination, so that a great and decisive importance is often ascribed to the results of chemical research. Compared with this the diagnosis and the proof of poisonings by medical find- ings is still difficult. The clinical-chemical laboratory methods are mostly adapted to the differential diagnosis of in- fections or organic diseases, the knowledge of the more subtle traces of poisons in the body is very incomplete. A connecting link is lacking between the medical and the chemical findings which would enable the physician to test completely and corrob- orate the results of the chemical investigations. For the microscopic-histological test of poisonings and, for the localized proof of poisons in the section by microscopic examination, the darkfield illumination of sections without microscfcpical findings and the silver sulfide method have proved suitable, particularly for the proof of minute traces of heavy metals, and also for proving the presence of the so-called trace- elements* Iron is often changed with poisonings. Moreover, these methods provide new and wide prospects on the course of functional histo-pathogenesis. As an example special findings in the island apparatus of the pancreas are mentioned, in which in the body zinc is regularly present, as an important trace element besides insulin, both of which are lacking in the diabetic gland. Discussion: BUHTZ: The careful and adequate preservation without fix- atives in glass receptacles (not metal, particularly aluminum vessels) is mentioned. In most cases too small quantities (WASSERMANN bottles) kept in unsuitable preservative'? are sent in. Besides the samples for a chemical toxical examination, parts of organs in formalin must always be sent in fixed for histological examination* Cases of poisoning are mostly not recognized by the medical practitioner• On the other hand poison is often wrongly suspected. A report is given on investigations concerning uranium nitrate, (radioactivity - photographic plate). HEUBNER: I have obtained excellent results with simult- aneous clearfield and darkfield illumination for the localizat- ion of particles of metal* GEMEINHARDT: Very weak methylr-violet solutions are not only dyed green to yellow by admixing sulfuric acid, but the plain-colored methyl-violet solution is removed* VI. PROCEEDINGS OF THE CONSULTANTS f COMMITTEE 0 N 0 T 0 R H I NOLARYNGOLOGY Translation prepared by: U. S. Naval Technical Unit, Europe, (Medical vSection) Office of the Naval Advisor Office of the Military Government (U. S.) Early and late surgical and orthopedic treatment of injuries to the .jaw and face. Tsee Section XV. Articles1 - 5) Hemorrhages endangering life as a sequel to injuries to the .jaw and face. (See Section XV. Articled - 7) Medical examination for fitness for assignment as listening sentry. TSee Section XIV. Article 5) Ear protective device. (See Section XIV. Article 8) 1. Determination of fitness for military service of registrants afflicted with diseases and de- ficiencies of the ear. Stabsarzt (Captain, MC.) Prof. MITTERMAIER In case of chronic otitis media it is considered im- portant to distinguish between the two clinical forms of meso-tvmpanic inflammation of the mucous membrane and epitvmpanic bone-destroying otitis media. Although the chronic otitis media *ith central per- foration of the tympanum mv>st in many instances be con- sidered as a disease "with tendency to relapses", it may be said, however, that the mild form is harmless. Otitis media in the majority of cases will be classed as a class B disease (fit for active service). A class L deficiency (fit for limited duty) will be assumed only if the suppur- ation of the mucous membrane cannot be brought under con- trol and causes considerable pain. Chronic otitis media with peripheral perforation of the tympanum: Only cases involving the formation of polyps, extensive cholesteatoma etc. will be classed as an L defic- iency. These require special and continual observation, especially because of the usual seauelae (labyrinthitis, meningitis, sinus thrombosis etc.). The epitympanic dis- eases which take a more or less regular course, without particular symptoms and which as a rule will only require occasional medical attendance every few months, will be classed as a B deficiency. Radical operations should be carried out only if none of the specified complications are involved, and if an es- sential improvement, that is to say the changing from an L deficiency to a B deficiency is likely to result. The dry cavity of a radical mastoidectomy is considered^as a B de- ficiency. Only in cases of continuous suppuration or ab- normal sensitivity to weather conditions will a classific- ation as an L deficiency be considered. In more severe cases with excessive irritability of the labyrinth, fitness for labor duties will be assumed. Fitness for active service in a field unit depends on whether or not it is possible to avoid exposure to rough weather conditions# A discrimination between the two forms of chronic otitis media is important in order to secure an appropriate treatment. Light and medium cases of inflammation of the mucous membrane with tendency to relapses can and should be treated by the army surgeon. It may justly be said that the efficiency in the service of these man depends largely on the experience and skill of the army surgeon. Chronic otitis media with bone involvement must be given particular and continual treatment by a specialist, who has to give the necessary instructions as to date and kind of further treatment. A brief entry in the paybook. pages 12/13, will be made when the outpatient or hospital treatment is over. The entry must be signed by the attending specialist, setting forth the specific form of chronic otitis media, such as otitis media chronica combined with inflammation of the mucous membrane, or otitis media chronica with bone caries, or otitis media chronica with cholesteatoma. Practical experience shows that impaired hearing is often undervalued in the general medical examination. The inability to hear whispered speech at a distance of 1 to 2 meters must, however, be considered, as a serious handicap in the performance of military duties, consider- ing the requirements of modern warfare. The army surgeon should be notified in the medical report of the existing deficiencies, so that provision can be made for the ex- emption from patrol duties, sentry duty at night, assign- ment to sound detection units etc. The proper evaluation of these deficiencies often leads to a classification in the L category. The fitness for active service depends also in these cases on a suitably selected assignment. In case of a malignant aggravation or steady psycho- genic defect of hearing it will not be considered suffic- ient if the examining surgeon personally has come to this conviction. Energetic treatment, best with the assistance of a neurologist (faradization) is necessary, until an im- provement is admitted. In case of relapse the threat of disciplinary action or punishment for malingering should be considered. Injuries to the ear due to detonations: Light cases will improve after a few hours, moderate cases after 2-3 days. Occasionally the improvement takes up to 10 - 14 days. Defects of hearing due to injuries to the middle ear (rupture of the drum membrane, hemorrhages etc.) often de- crease considerably in the course of time. The assumption is justified that lighter injuries to the inner ear may similarly recover fairly often. A prognosis is to be made only with the greatest caution. In more severe cases a limitation of hearing persists. 159 Injuries to the ear drum: Even if not followed by a suppuration of the ear the afflicted soldier should be given a fortnights leave from duty and have the ear treated regularly during that time. Many such perforations are likely to recover. Besides impaired hearing, the attendant phenomena of injuries to the inner ear are to be taken into corisiderat- ion, such as defective hearing, disturbing buzzing noises in the ears, in the beginning hypersensitivity to cold, to noise etc. About two T-eeks after an organic injury to the inner ear has occurred it seems that no further change for the better may be expected. The medical opinion of the case is to be stated in detail, because it is to be expected that after some years a claim will be put in to the effect that these injuries by detonation are responsible for a physiological impairment of hearing which actually is due to old age. An ear, once injured, is more susceptible to further injuries of the same kind that a sound ear. As to disturbances of the equilibrium apparatus as a consequence of residual states after diseases of the vesti- bule, no important experiences could be made under field conditions. (A corresponding change of the list of defic- iencies is provided in the new edition (note of the editor). This refers to the booklet distributed to physicians for a standard system of evaluation of disabilities. A copy has been translated by this section.) Discussion: FTNDLER: Bilateral chronic accumulation of relapsing infection of the middle ear should be classified as U 32 (fit for labor). In cases of rupture of the drum membrane caused by detonation, suppuration occurs mostly within the next fort- night, if it occurs at all. Therefore, these patients should stay for about a fortnight at the collecting station for casualties of the forces in the field under observation of an aurist, or for treatment in the special ward. If suppuration of the middle ear sets in they should be sent to the hospital, as should those showing simultaneous de- ficiencies of hearing. THIELEMANN: 1. According to the experiences in the home army it is of no use to determine the degrees of fitness only by the values found for their ability to hear whispered speech. Experience has shown that a great many of the registrants pretend not to hear whispered speech etc. The classificat- ion by the aurist should therefore be as follows: slightly defective hearing, defective hearing, medium or hla-h degree, without an exact statement as to the result obtained with regard to the ability to hear whispered speech. 2. Entry of the results of hearing obtained by the experienced aurist into the pay-book are to be recommended, since the results of the hearing-test obtained by the field surgeon examinations vary widely. Similar entries should be made concerning the character of any existing infection of the middle ear. 3. There are difficulties as to the classification of vestibular disturbances, slight vestibular disturbances, such as after injuries to the base of skull, must be con- sidered according to the classification table as diseases of the inner ear and will be classified as such under U 32 (fit for labor). In case of disturbances of the equilibrium apparatus this classification is not available. The classi- fication under L 19 does not always fit the case. 2. Determination of fitness for military service of registrants afflicted with diseases of the throat and nose. Oberstabsarzt (Major, MC.) Prof. KINDLEH The classifications given in army manual 252/4 have proved highly satisfactory for the field of nose and throat diseases after about five years of war experience. By the orders concerning the degrees of fitness, issued in Decem- ber 1943, they have undergone an effective simplification. The stable frame of the army manual 252/4 has proved necess- ary above all for the purposes of the army in training. A certain flexibility in the judgement has been found desirable for the field array. It is important, particularly in case of chronic illnesses, to take into consideration besides the symptoms and the objective finding of the disease also the previous employment and the present task of the patient. The general and medical-tactical situation too (static warfare, advance or moving defensive front with heavy fighting, poss- ibility of transportation to a special hospital, length of absence from the unit during the stay in the hospital, and other things) are to be taken into consideration. It 'is ad- visable to keep the man with his unit by using palliative measures. Moreover it is proposed: 1. to treat chronic accessory nasal sinuses conservat- ively if possible and to classify them as L 34 (conditional- ly fit for active service). 1 2. To classify ozenas, apart from very severe cases, under L 34. 3. To introduce L 35,1 (conditionally fit for active service) for chronic tonsillitis, in order to further an early enucleation of the tonsils. 4. To classify partial traumatic paralysis of the voc- al cords as L 18 or L 42 (conditionally fit for active serv- ice) provided that neither dyspnoea nor aphonia is present* In the case of aphonia, U 42 is suitable. If a plastic oper- ation of the vocal cords gives some hope for improvement of the voice, U 42 would be the proper classification, at least for a certain time. 5, To hospitalize cases of a severe, non-specific, chronic laryngitis, combined with hoarseness, as U 42, in order to obtain a speedy improvement of the degree of fit- ness for active service. % Discussion: Ozena, sure to become a nuisance to those closely associated, (confirmation by the snecialist is re- quired I) should be classified as unfit for service. 3. Judgement of general fitness and fitness for active service in the German Air Force in case of dis- eases of the ears, the throat and the nose. Oberfeldarzt (Lt. Col,. MC.) Prof. HUENERMANN The soldiers of the German Air Force are divided in two large groups namely aviators and parachute troops on the one hand, and ground crews on the other hand. Speci- al standards of fitness with regard to throat, nose, and ears are required only for members of the interception services, the selection of which was discussed in connect- ion with the army physiology group. Otherwise the stand- ards of fitness for the army apply also to the ground units of the Air Force. The standards set for parachute troops are the same as those which qualify for unlimited service in the in- fantry, that is to say fitness for active service accord- ing to army manual 252/4 of the 1 April 1944. Moreover it has been ordered that hyperexitability of the equilib- rium apparatus and stuttering as well as a removable dent- al prothesis or inability to chew common food without a set of artificial teeth must disqualify the soldier for parachute troops. In the examination by the physician for prospective members of the Air Force the following facts must be con- sidered: Nasal respiration must not be hindered serious- ly, chronic diseases of the nose, of the accessory nasal cavities, of the pharynx, and of the cavity of the mouth makes a man unfit for service in the Air Force, they cause disturbances which render flying activity more diffi- cult. Such disturbances are really very important, because they easily escape medical observation during the assign- ment period and, may interfere with flying operations, when there is too little recognition that not only the disturb- ances of the pressure equalization of the eustachian tube cause considerable pain, but that pain may also arise in no lesser degree from the accessory nasal cavities. These patients complain Incessantly of headaches particularly bear- ing a high altitude flight. During the examination patho- logical symptoms are seldom detected unless a special X-Ray photogram is made of the accessory nasal sinusis, which often show a partial (one-sided) haziness in the photograph of the frontal cavities. In this connection reference is made to the observations of HERRMANN at Greifswald who has described hemorrhages into the frontal sinus cavity during dives in planes. In the classification chart this condit- ion should be listed under Nr. 34 as L 34, particularly with regard to a chronic involvement of the accessory cavities. As to the examination of the ears, the instructions for the medical examination for fitness as fighter pilot, aerial gunner, and as paratrooper or parachute gunner are as followss The eustachian tube must not be obstructed, whispered speech must be heard at least at a distance of 2 meters. Considerable hypersensitivity of the vestibular apparatus renders the individual unfit. Contrary to the requirements of peace-time, these very strict conditions have stood the test in practice so that a modification is not taken into consideration from the point of view of the aurist. In my opinion great importance must be attached to the fact that the accessory nasal cavities which include also the middle ear, have a free communication with the nose or the naso- pharyngeal cavity, for otherwise considerable pains causing discomfort to the flying crew will occur during high alti- tude flights and dives and this hampers the execution of aerial operations. In addition this pain may also endanger the security of the pilot and thus the lifes of the passen- gers as well. A diagnosis is difficult, disturbances of ventilation are always to be taken into consideration, when the patient complains of local headaches and when either a distortion of the nasal septum or other evidence of a dis- turbance of ventilation are seen. 4, Judgement for general fitness and fitness for active service as regards diseases of the ears* the throat, and the nose# Special requirements of the Navy• Marineoberstabsarzt (Lt. Comdr.. MC») NOACK On the part of specialists for diseases of the threat, the nose, and the ears, with regard to the^19 special careers of the Navy (Friegsmarine) and. to the special standard of fitness for the submarine service, the earlier standards of fitness must be retained which at the same time give an ex- act idea of the fitness of the soldiers for military service. Fitness for service on submarines depends on the directions published in 1943. For all careers requiring service on board cr plane sound ears without any perforations of the tympanic membrane are required. Ability to hear whispered speech at a distance of 4 meters or 1 meter in one and 6 meters in the other ear. Navy radiomen, sound operators and sailors who operate the radio direction finder must have unimpaired hear- ing (on both sides ability to hear whispered speech at dis- tance of 6 meters). Soldiers with mild, mucous mesotympanal suppurations are fit for general service in the field. All- fetid suppurations of the bone are conditionally fit for milit- ary service. Classification in A 33 and B 33 are proposed, in which class A diseases mean only mild diseases of the nasal cavity without serious disturbance of the respiration, B - dis- eases, however, mean more marked narrowness of the nasal cav- ities and the nasopharyngeal area which can, however, be corrected by surgical operations. The ability to smell is to be judged by the rhincloglst not as A 18 but as A 33* Chronic inflammation of the nose and the accessory sinuses make a registrant unfit for service at sea and on submarines; they are, however, still fit for service in the field and should be classified as conditionally fit for active service. Ozena is still retained as a class IT disease because of liv- ing conditions aboard ship. Chronic tonsillitis must be cured by tonsillectomy before embarkation. B 42, ’’inveterate hoarseness”, makes a man unfit for service on the telephone or microphone (BU), because of the difficulty of making him- self understood and inaccurate transmission of orders. Discussion: UFFENORDE: In the Navy, which requires every man to be examined as to fitness for the submarine service, we take it for granted that about 10 per cent of the men are unfit for service from the viewpoint of the aurist. Of these only 5 per cent can be cured and made fit for active service by spec ial operations: adenoidectomy, resections of the septum, ton sillectomy etc. Because of this additional tasks have come to our special departments, we have to guarantee a free ven- tilation of the eustachian tubes on both sides, for in the submarine service not only high pressure but also partial va- cuum affect the ears in a higher degree than during tf'orld war I, and we have now to deal with irreversible disturbances of hearing. Thus I found in the case of an artificer warrant officer a one-sided hearing loss of a high degree which had developed in five months and which arose during an excessive partial vacuum. By a faulty execution of orders the Diesel air intake valve had been closed and the motor very quickly exhausted the engine-room, the patient felt a marked diffi- culty of hearing on both sides and for some days disturbances of the equilibrium when getting up in the morning. The hear- ing capacity was restored in one ear in a few days. In the other ear complete recovery seems very doubtful. This case is precisely analogous to the observation of a case of marked one-sided deafness lasting for 2i years after the emptying of an underpressure chamber. In my case I must assume the ef- fect of underpressure, while in the case described by SCHRA- DER the deafness was caused by a relative increase of press- ure. 5. Experiences with the ear - battalion of Military District VIII. Oberstabsarzt (Major. MC.) Prof. PERWITZSCHKY Many of the patients suffering from ear diseases go from one physician and one hospital to the other and be- come therefore a burden not only to the regimental surgeons, to the evacuation units, and to the hospitals, but also to the unit to which they are assigned. According to my proposal the diagnosis of earache and its treatment have for some time been entered into the pay- book of every soldier, e.g. chronic suppuration of the mucous membrane, hospital treatment not required, even with consid- erable secretion etc# 164 This instruction was not of much use because men suf- fering from chronic suppuration of the middle ear are over- evaluated by the army surgeons because of their exaggerated description of their complaints; yet these patients could do the heaviest work without difficulty in their civil pro- fession, even under unfavorable climatic and professional conditions without ever having consulted a physician. Starting from these baaes the surgeon of the Military District VIII proposed to create a battalion for patients suffering from ear diseases. The purpose of the creation of this unit is: 1. To rid units, physicians, evacuation units, and hospitals of the above mentioned patients and to place them in charge of one physician who is an army surgeon and who is thus enabled to observe the soldiers not only in the hospital and in the sick bay, but also while on duty. 2. To reduce the number of men reporting sick, which will naturally happen when they know that they are going to be attached to a special unit. 3. To raise the efficiency up to a certain standard and possibility of a suitable employment of every single soldier according to the kind and severity of his illness. 4. To place these men under the systematic command of energetic officers which is necessary with the patients who complain again and again of all sorts of imaginable aches and pains. 5. To provide thorough military training which could not be carried out before with a great number of these men. 6. To improve the possibility of an employment of the unit in its entirety, in order to free other units in the army administration district behind the lines or at homo. 7. To send patients suffering from ear diseases, who are unfit for military s.ervice, back to the civil section where they may be of better use. The Commanding General of Military District VIII agreed to the proposal of the district surgeon and ordered the ex- perimental formation of a battalion for patients suffering from ear diseases. It is now nine months since that unit was formed, so one may be permitted to form an opinion about this project. Those assigned to this battalion were patients with ear diseases, continuously or constantly relapsing diseases of the ears with the following findings; 1. One-sided central perforation of any size, while the other ear is anatomically and functionally sound; 2. Central perforation on both sides with sufficient ability to hear; 165 3* One-sided total loss of hearing, while the other ear is in good condition; 4. One-sided defect at the posterior edge with slight secretion while the other ear is in good condition; 5. Large one-sided distinct defects of the recessus epitympanicus, while the other ear is in good condition; 6. Radical operation on the ear on one side which suppurates frequently with good hearing of the other ear; 7. Continuously draining ear, following a radical oper- ation on one side (tube angle) which requires constant super- vision; 8. All ear diseases that have become dry and that are now judged according to B 32, but that are sure to begin to discharge again as soon as the patient is on active duty. Not fit are: 1. Soldiers who have additional group L diseases; 2. Suppurations of all categories with insufficient hearing (under B 31); 3. Indistinct suppurations of the recessus epitympanicus with small fistula and cholesteatoma; 4. Suppurations of all categories with demonstrable involvement of the labyrinth; 5. Operative gunshot wounds in the ear with complaints of postcommotional pains. The soldiers brought together in the "ear battalion” were then divided into four groups: Group 1: comprises those whose otorrhea is quiescent and who have useful hearing capacity. Monthly control ex- aminations are sufficient. This group numbered 209 soldiers when it was formed. They were employed for guerilla warfare or similar duties. Group 2: Corresponds generally to the findings or group 1, but requires treatments once or twice a week. Strength 218 men. These patients are fit for dutv in the line of communications area (patrol duty, escort}, since the hearing capacity has already decreased with most of them. Group 3; To this group belong those with considerable loss of hearing and in addition an ear disease which re- quires treatment two or three times a week. Strength 195 men. They are employed as a construction group. Group 4: This group consisted of those, who were dis- charged after a short period of observation, which probably would not have happened if they had remained in their former units. Strength 33. All companies consisting of patients suffering from ear diseases have their depot battalion at home to which they can be sent back in a case of more severe illness, and from which the units consisting of patients suffering from ear diseases are renlenised. All the men belonging to an "Ear Battalion" are returned to the battalion during their retention in the army in order to avoid their former depot battalion, so that after being wounded, the round of all the different hospitals could begin again. It is clear that with the formation of this battalion initial difficulties had to be overcome. At first it was not easy to prepare the members of the Armed Forces which came from various formations and arms of the service for their various assigned duties but commanders who were selected for this purpose were successful in over- coming this difficulty. Of course the regimental surgeon must be a specialist who has not only a good military presence but who is an expert in the special field of ear diseases, for only a well trained and responsible medical officer who knows also how to judge the complaints of the soldiers is of use. The successful existence of the battalion depends entirely on the quality of the specialist. It is very interesting to learn how ear diseases react even under the greatest hardships and under narticularly un- favorable conditions. In a test of endurance from 27 - 29 January 1944, which was undertaken in unfavorable weather, the following picture was shown with a participation of 35 N.C.O.’s and 442 soldiers; 18 men fell ill with angina, 5 men fell ill with pharyngitis and laryngitis, 3 men fell ill with bronchitis, 3 men fell ill with grippe-like infection, 1 man fell ill with lumbago, 3 men fell ill with neuralgia, 2 men fell ill with muscular rheumatism, 1 man suffered a contusion, 4 men were after a wounding, hindered in walking, 21 men fell ill with diseases of the feet, 1 man had to be sent to a hospital on account of an acute cardiac weakness, 4 men fell ill with an acute relapse (without suppurat- ion of the middle ear (otitis media)), 5 men complained of dizziness without severe disease, 2 men suffered tearing of ligaments. With this I come to the conclusion of my report: According to the reports of the commanding officer and the medical officer of the unit the formation of this battalion for patients suffering from ear diseases, first proposed for Military District VIII and carried out practically by General- arzt (General, MC.) Dr. WALTER has thoroughly proved very satisfactory. 167 Discussion; VON EICKEN; As aurists for the battalions for patients with ear diseases younger specialists are being considered suitable, who as yet have limited experience in the oto-surgic- al area but who have proved to be skilful and energetic in the military service. Many of these have not been considered hi- therto as specialists. MITTERMAIER: With men who already belong to a field unit, the regimental surgeon should decide after consultation with the specialist, as to whether the patient suffering from ear disease can remain in his formation or must be sent to the battalion for patients suffering from ear diseases. Directions concerning the judgement of the general fitness and fitness for military service with diseases of the ears, the throat, and the nose; experiences of the battalion for patients with ear diseases in the Military District VIII. The determination of fitness hitherto stated in the table of diseases of the otorhynolaryngology have been proved satis- factory after a war experience for approximately five years. It has been shown, however, that the chronic diseases, partic- ularly those of the accessory sinuses and of the ears, must not be judged so strictly as is admissible during peacetime. Thus the majority of the chronic diseases of the middle ear can be diagnosed as class B diseases. Impairment of hearing of a high degree, however, renders every case conditionally fit for military service as class L diseases. Since a certain proport- ion of the patients with ear diseases remains with the unit in the main fighting zone, these must be treated by the regiment- al surgeon. An instructional pamphlet dealing with the treat- ment of chronic diseases of the middle ear to be carried out him must be prepared. Following the excellent experiences which have been made with the formation of a special unit of patients suffering from ear diseases in Military District VIII, these formations will be introduced in other military districts too. For certain special careers in the German Navy or Air Force special requirements are necessary. 6. Concerning different grades of disablement and the awarding of the Found medal to men pounded in the field of otorhynolarvngology. SS-Obersturmbannfuehrer (Lt. Col., MC. of_ SS- froops - Elite Guard) Prof. RAPTH Directions: Details concerning the different grades of disability- are not recorded here again. Instructions on this subject are being prepared. (Editor’s note). If influence by enemy action is to be assumed in a case of difficulty of hearing approximating deafness the wound medal in silver may be given. Consequently if influence by enemy action is to be assumed in a case if impairment of hearing of a lesser degree the wound medal in black seems appropriate. 168 In case of an injury to the vestibular apparatus, sup- posed to be due to enemy action, the wound medal in silver may be considered. In case of wounds caused by a gunshot into the larynx, combined with a distinct disturbance of function (respiration, voice) the wound medal in silver is suitable, the wound medal in gold may be awarded when such an injury amounts to a com- plete loss of the larynx. With all awards of wound medals in silver and gold the injury must present some permanent damage. 7. the treatment of frontal-basal gunshot wounds of the brain and their sequelae. Oberstarzt (Colonel, MC.) Prof. TOENNIS I* Frequency and classification. Among 4141 gunshot wounds of the cranium 80 per cent of the wounds were of the vault of the cranium and 20 per cent of the base of the skull. The latter are divided into fronto-basal (64.55 per cent) temporo-basal (27*37 per cent) occipito-basal ( 8.08 per cent). According to the kind of injuries of the brain we dis- tinguish between locally limited gunshot wounds or depressed skull fractures caused by gunshots (75.6? per cent), and those caused by the bullet penetrating deeply and destroying the brain, those due to either lodging in the wound area (22.54 per cent), or passing through it (1.79 per cent). II. Causes of death. 1. "Seriousness of the injuries”* Among the causes of death among wounded men with fronto-basal depressed skull fractures due to gunshots the serious injuries amount to a third, with the gunshots where the bullet lodges in the wound area to a half, and with the gunshots where the bullet passes through the wound area to four fifths. As was shown by clinical observation, this is a case of Insufficiency of the central vegetative regulation, that is to say, the consequence of a traumatic injury to the brain- stem. This observation is corroborated by the fact that 76.5 Per cent of the fatal cases were unconscious for days after depressed gunshot fractures and 100 per cent of the fatal cares after gunshot wounds with the bullet lodged in the wound area. 2* Infection: Among infections, complications of the inner cavity of the skull with the frontal basal injuries, direct infect?on of the subdural and subarachnoid spaces as well as infection of the basal cisterna are most frequent. The indirect meningitis we find during the first week only with a primary opening of the ventricle, during the later weeks as a result of an abscess breaking through into the ventricle area. The progressive encephalitis of the medulla v'hich predominates among depressed gunshot fractures in the cranium, is comparatively rare in this case; nor are such complications hemorrhages and edema, causing an increase of cerebral pressure, frequent with fronto-basal gunshot injur- ies during the first week. Ilia Treatment of the wound* The aim of surgical treatment is to prevent infection of the cerebral wound, of the subdural space, and of the fluid spaces. The primary infection of a cerebral wound is over- come by an radical removal of all fragments of brain, blood, and foreign substances, secondary infection by a water-tight closing of the opening of the dura by use of orbital tissue or of a periosteal flap. In order to avoid subdural empyema, the subdural hemorr- hages are regularly removed during the treatment. In prevent- ing meningeal infection, the removal of the fluid in good time has proved very successful in addition to the sulfonamide treatment. Among the primary operations of the ventricle the rate of fatal cases of meningitis was reduced to 10 per cent. Fatal cases with depressed fronto-basal gunshot fractures (32.14 per cent) were reduced to a third (10 per cent). IV. Final results. Of all the cases of fronto-basal gunshot wounds (226) observed from the first treatment until their discharge from the home hospital, 25.66 per cent died. Of those who sur- vived (74.34 per cent), 17.7 Per cent were discharged as un- fit for military service. 56.64 per cent returned to the Armed Forces, 10.8 per cent fit for military service, 25.22 per cent fit for garrison duty at home, 21.24 per cent fit for labor only. Out of 40 cases of fronto-basal depressed skull fract- ures due to gunshots only 24 cases (about 10 per cent) had to be discharged from the Armed Forces because of a traumatic injury to the brain. In only eight cases of bilateral in- juries of the frontal brain did the sequelae lead to a dis- charge from the Armed Forces. 8, Fronto-basal gunshot rounds of the brain accompanied by injuries to the accessory sinuses and their later development. Oberstarzt (Colonel. MC.) Prof. PEIPER The speaker specifies three groups of fronto-basal gun- shot wounds of the brain with injuries to the accessory sin- uses, in which the operative method is fundamentally differ- ent; 1. the group of recently wounded cases, 2. the group of recently infected cases, 3. the group of older cases in which in consequence of and insufficient operation, secondary-operations in the area of the accessory sinuses and the brain were required, and in wh? ch the area of the accessory sinuses is in most cases in- fected while the scar of the brain is not infected. First he discussed several surgical methods used with group 1, with which, if it is not a question of small operat- ive openings of the accessory sinuses which can be closed im- mediately without any major operation according to the situat- ion of the injury, the frontal wall must always be removed entirely, including the arcus, while of the rear wall only so much is removed that the cerebral wound is easily accessible. The speaker asked for a wide extranasal access to the nose in any case, even if the ethmoidal cells were not primarily in- jured, since otherwise infections occur regularly and the frontal sinus does not heal up. In the case of recent in- therefore, the anterior and posterior ethmoidal cells mtist be removed according to operation. After the treatment of the cerebral wounds the dura must be closed, preferably by plastic operation with pieces taken from the galea or with pieces of amnionic membrane. For these purpos- es the excellent effect of a pendunculated piece of mucous membrane of the nose, is especially mentioned, which presents the natural protection at the base. The 48-hours limit should not be exceeded in case of recent injuries. Insufficient or total lack of communication with the nose nearly always caus- es infections. Infected gunshot wounds must be operated as early and as radically as possible. The surgical rules are almost the same, a cerebral wound, however, is drained around a genuine sponge. This sponge is accessible from the area of the bridge of the nose. In cases of infected gunshot wounds of the ethmoid bone which require access from the frontal sinus to the nose the frontal wall of the frontal sinus had best not be left, since gunshot infections heal up badly or not at all. In old cases an operation on the old scar should be avoided if possible, since otherwise the infected area of the accessory sinuses and the scar of the dura are opened with the first incision. Before a large pyramid of splinters in the brain the source of infection in the ac- cessory sinuses must be removed. If the arachnoidal bursts open in the infected area of the frontal sinus during the operation, a plastic operation is to be preferred to open treatment. The ideal is an early operation which presupposes the operating surgeonfs thorough familiarity with otologic methods. SLt Initial treatment of fronto-basal gunshot Founds of the bfraln accompanied by Injuries of the ac- cessory sinuses and their later development, Oberstabsarzt (Major. MC.) Prof. SEIFERTH This report is to be published in "Archiv fuer Hals-. Nasen-, Ohrenheilkunde” (Archives for Otorhinolaryngology)• The chief task of the initial treatment of gunshot wounds in the brain is to prevent infections. The prevention of in- fections is still more important in cases of basal gunshot wounds in the brain in the area of the cranium* In cases of basal gunshot wounds accompanied by injuries to the accessory sinuses, secondary infection of the brain and its membranes threatens from the wound in the soft parts and in the brain and from the nose by Way of the opened up accessory sinuses. Besides^this an injury to the accessory sinuses may cause in- tracranial complications independent of the brain wound. Of all accessory sinuses the maxillary sinuses are af- fected the least often in case of basal gunshot wounds. In case of gunshot wounds in the maxillary sinuses, comminuted fractures and injuries to the brain may occur at the base of the skull by the effects of explosion* On account of the danger of an infection penetrating in- to the inner cavity of the cranium, basal gunshot wounds with injuries to the accessory sinuses must be treated surgically as soon as possible and at any moment the rounds have been inflicted even if injury to the dura and the brain has not occurred, or is not to be assumed. The only contrary indic- ation for an operation are states like shock and collapse with a threatening failure of the circulation. The direction of incision by which the cerebral wound and the injury of the accessory sinus can be opened at the same time, is demonstrated by means of illustrations. In operation of the accessory sinuses, the usual methods must always be applied because they afford the best access to and the best survey of the exposed accessory sinuses, and fre- quently give the great advantage that the gunshot wound can be avoided and the operation need not take place in the in- fected area. The exposure and-treatment of an additional injury of the orbit is of the highest importance. In an opening up of the ventricle the closing of the dura must take place as a matter of routine after the second day, if no meningitis appears* Besides, in other cases the closure can be made even as late as the seventh day. In- dications for this kind of early treatment are given. An operation wound above the eye-brow is closed within the first two days, after the closing of the dura. Access to the nose is absolutely reauired in all cases with a prim- ary suture of the soft parts. In cases to be re-treated surgically the nose is not exposed. In the case of gunshot wounds with the bullet lodging in the brain the prospects are considerably worse than with un- complicated gunshot wounds of the accessory sinuses, because of the larger surface of the wound and the more extensive contusion of the brain. A case is mentioned where the splint- er, the size of a rice-grain, sticking in the cerebrum was followed by a meningitis that was healed up by conservative means. In the case of gunshot wounds with the projectile lodged in the brain, the place where the bullet entered is always to be treated first, since in many cases the projectile can be approached from the hole at the point of entrance. For the treatment of gunshot wounds with the missile lodged in the brain an enormous magnet is indispensible. Splinters re- maining in the area of the hypophysis which have entered from the accessory sinuses or any other part of the facial portion of the skull, must be removed by way of the accessory sinuses. When, after gunshots with the bullet passing through the brain, the missile lodges in the accessory sinuses, the treat- ment of gunshot wounds with the projectile remaining in the affected part must not be delayed,because intracranial com- plications would develop sooner or later transmitted from the accessory sinuses and from the untreated wound of the dura and the brain. When a subdural hematoma is suspected (tautly stretched, dark-blue colored dura and symptoms of cerebral pressure) puncture is to be undertaken. The exposure of the uninjured dura is not advisable. Among the complications in gunshot wounds at the base of the skull, meningitis is most frequently observed. Patho- genetically five forms may be distinguished, which, as regards prognosis, are to be judged differently: the infection of the meninges from the accessory sinuses with intact dura (spreading meningitis), meningitis due to infection of the external fluid spaces from the dura-cerebral wound (direct meningitis), meningitis as a result of an er importance for prevention of late complications. On principle an infected cerebral duro wound must be treated surgically, under visual control, as carefully and directly as possible by the shortest route of access. As a basis for the direction of the incision, KILTAN’s operation is to be considered which according to the peculiarities of the injury nay be modified and widened by auxiliary incisions. Enough of the injured bony cerebral wall must be re- moved to prevent overlooking an extradural hematoma or an abscess, and to expose an injury to the dura so that it is easy to inspect. The treatment of an infected injury tn the cerebral dura in the area of the frontal sinus without affection of the ethmoid bone must aim at an obliteration of the sinus according to RIEDEL*s operation. The removal of residual mucous membrane hardly to be recognized macroscooically is really successful only with the aid of a small wire brush. By this a proper closing of the ductus is obtained. Therefore, it is unnecessary to operate at the same time the uninjured, uninfected frontal bone and to a communication to the nose. 175 If in the case of a large frontal sinus only la partial obliteration of the lateral sections is possible, a communic- ation is formed between the remaining, surgically treated me- dical portion of the sinus and the nose in any case only after a thorough healing of the wound in the dura by a typical de- bridement of the ethmoid bone. The ideal purpose of our proceedings in case of infected, isolated frontal sinus brain injury is to prevent an addition- al infection of the nose whether altogether or at least until the closed healing of the cerebral wound by limitation of the surgical area to the frontal sinus, and to prevent the healed up cerebral dura wound as much as possible connection with an open accessary sinus system. Injuries to the cerebral dura in the area of the ethmoid b°ne roof require a complete removal of all ethmoid bone cells, including the opening of the sphenoid bone sinus from an or- bito-nasal incision, from which the after-treatment of the cerebral dura wound is also undertaken. Even if some groups of cells do not appear infected, macroscopically we avoid part- ial debridement, in order to create smooth wound conditions, easy to inspect in the neighborhood of the later developing scar. There is no cogent reason fnr including the uninjured and uninfected frnntal sinus in the surgical area. Injuries to the lamina cribrosa have surprisingly proved to be much less dangerous than we were inclined to estimate them in the beginning on the strength of prewar^experience with the apparently much more virulent genuine inflammations. Serious comminution? of the upper accessory sinuses, in most cases combined and bilateral injuries to the ethmoid bone- frontal sinus, affecting the lamina cribrosa and the orbits require an exposure of all affected spaces and of the injured dura, often by modifying the external direction of the incis- ion and of the surgical procedure. Positive general rules can*, not'be laid down, as wide external openings rendering tha*'ln- jured area accessible and'wounds in the sott parts freouently are already present. In case of bilateral injuries t" the upper accessory sinuses or comminution of the inter-frontal septum such as frequently occurs in unilateral injuries tn the frontal sinuses too, a "Median Drainage of the Frontal Sinus” (0. MAYER) has proved to be advantageous. Missiles are to be removed from gunshot wounds when the bullet is lodged in the upper accessary sinus system without P0gap(5 to their size and their distance from the cerebral wall. This is accomplished by an external radical operation of the sinus in question. The idea of trivial injuries cannot be admitted in this case. Injuries of the dura and the brain at the roof of the ethmoid bone offer, according to our experience, a better prognosis than those in the area of the posterior wall of the frontal sinus. Depressed skull fractures caused by gunshot into the thin cerebral walls of the accessory sinuses present, in most cases, an open bone gap, i.e. with a decided tendency to prolapse. The after-treatment of Infected injuries to the cerebral dura should be undertaken individually; valuable measures in this case are a dilatation of the cavity by "gradual draining of the cerebral spinal fluid" and a radiographic picture of the cavity filled with air or radiopaque solution. In case of complicated, hidden or small abscesses a tamponade by means of a rubber sponge is hardly practical. Also an apparently spontaneously healed up fronto-basal injury must be dealt with by a late operation, if an infect- ion of the accessory sinuses is proved. Its performance is technically very difficult and is accompanied by greater risks than an operation at an earlier time. Besides a late abscess and late meningitis the formation of mucopyozelene is a serious late complication after injuries to and operations on the accessory sinuses. Only 12 per cent of all treated fronto-basal injuries had already been dealt with before they were sent to the special ward of the general hospital in the home territory. Discussion concerning the reports on fronto-basal gunshot wounds in the brain; MUENDNICH: In the discussion on the reports concerning an early operation of fronto-basal gunshot wounds MUENDNICH refers to his treatise published in "Zeitschrift fuer Hals- usw. Heilkunde", 49/1943 (Periodical for Otorhinolaryngology 49/1943) and stresses the following points of view: As regards the location of the incision he remarks that the typical incision along the supra-orbital ridge which turns medially to the area of the lachrymal bone is prefer- able, while a commonly used incision which begins laterally just as the first incision, but ands above the root of the nose, is to be used only when it is not necessary to expose the ethmoid bone. A third location of the incision is ment- ioned, which is suitable for gunshot wounds abnve the supra- orbital ridge, and which has the advantage that the skin wound is situated at some distance from the seam of the dura and that the soft parts can be pressed more easily against the frontal brain by tamponade. He warns against auxiliary incisions the center of the forehead if the is damaged externally, since by this the soft parts of the fore- head become useless for later plastic operations on the nose. They should not be made down to the bone immediately, so as to enable one to prepare periostical-galea patches for a plastic operation of the dura. He points out that if the dura is exposed, operations on the accessary sinuses which are not thoroughly carried out, may lead even years later to meningitis and wandering abscesses. Therefore incomplete debridement of the access- ory sinuses is to be discarded. If the frontal sinus is affected without openine up the ethmoid bone - from the frontal cranial fossa - the typical operations of the accessary sinuses should be avoided. The bottom of the frontal sinus is to be left as it is, the mue- ous membrane, of the bottom and of the medial wall is to be loosened with a rasp and removed. In the area of the operation the mucous membrane is loosened and turned in towards the ethmoid bone or removed. A periosteal-galea flap may complete the closing of the in- fundibulum. The ethmoid bone, however, remains absolutely intact. By this means the dura seems to be protected in the long run against infections spreading from the sinuses. (Satisfactory translation of the next paragraph could not be made because of blurred text. Editor’s note.) MITTEHMAIER: In case of a primary closing of a wound caused by fronto-basal cerebral injuries a simultaneous routine treatment of the frontal sinus and ethmoid bone are rarely required. It is, however, not sufficient only to a communication with the nasal cavity. Opening up the cellular system of the ethmoid bone means an infection of the cells which were removed. A very careful after-treatment is required after every operation on the nose. - If surgical wound treatment is required, it is perhaps better to postpone the operation of the nasal accessory sinuses until a later time. HUBERT; Of 1000 gunshot wounds of the brain operated on by myself at the eastern front 13 per cent were fronto- basal ones. For my report I have selected 600 sick-reports in order tn eliminate as far as possible faults of judge- ment which might arise by differences in the external con- ditions. The wounded came mostly from swampy areas; the in- juries were mostly caused by shell splinters, their first treatment had taken place in the cerebro-surgical depart- ment of a base hospital near the front and within 24 to 72 hours after they had occurred. The time of observation till the evacuation into a hospital behind the lines amounted to 4 weeks on an average. Of the 600 gunshot wounds in the brain with which the report deals, 80 cases showed an involvement of the accessory sinuses. Among 63 fronto-basal gunshot wounds in the brain combined with tearing of the meninges which were operated, in only 19 cases could a closure of the dura be achieved by dura suture or by plastic operation. In 44 cases (70 per cent) a water-tight closing of the dura gap had to be given up because of 1, a distinct infection of the cerebral wound was evident, or 2, gunshot wounds with the bullet passing through were contaminated to such a high degree that a certain physical cleansing could not be achieved, or 3, by the anatomic conditions, e.g. in case of cerebral wounds in the area of the sphenoid bone and of the orbital infundibulum a closure of the dura gap was precarious or im- possible. In these cases after the surgical treatment ef the accessory sinuses a tamponade was performed by means of moist DAKIN1s gauze or iodine - iodoform gauze. It assists the drainage, preventing at the same time a cerebral pro- lapse. The tampon is removed on the ?th day and renewed every 2-3 days, until the wound cavity is filled with granluations. Lumbar punctures must be performed in order to equalize the pressure and to treat a nossible meningitis according to the usual points of view. Of the 19 cases with fronto-basal injuries to the brain which were treated by closing the dura, 13 (3 per cent) (sic) died, while among 44 cases of injuries to the brain treated with tamponade, 13 died (30 per cent). To enable one to furnish a comparative calculation of suc- cesses expressed as percentage, comparing the different techniques, the figures are indeed too small, apart from the various conditions under which the methods of treat- ment were applied. The difference between the tyro ratps of success (30 per cent minus 16 per cent ■ 14 per cent) exceeds by only a little the medium rate of error which is computed at ± 10.9 per cent. The figures keep within the limits of the losses to be expected with gunshot wounds in the brain, as known by experience; they show that even with the often indispensable tamponade treatment fair re- sults may be achieved. (Editor’s note: This paragraph not entirely clear in the German text.) WILDEGANSs Most of the patients who sustain injuries to the fore-brain do not lose consciousness at the moment. The smaller the area affected by the injury, the less is a concussion of skull and brain in their entirety, with the corresponding clinical picture of unconsciousness and irritation, to be exnected. The larger the area affected, the more likely are these effects to occur. (Wounds caused by ricochet and grazing shots.) Commotio cerebri generally develops only if the direction of the effect of the trauma is towards the rear cranial fossa (Rhombencephalon and ependymal nuclei). Relatively frequent injuries are caused by contre-coup (occiput, cerebellum, orbital section of the frontal lobes, anterior part of the temporal lobes, windings of the brain in the area of the great falx and of the tent- orium, between vertex and temporal brain). Only those in- juries are to be considered as genuine contre-coup injuries when the cerebral sections situated between the area of im- pact of the projectile and the remote focus of contusion show no rough anatomic changes (propagated skull fracture, hydrodynamic forces, straining and tearing of leaving or entering nerves or vessels). More frequently there is a more or less broad track of contusion which traverses the brain in a fronto-occipital or a fronto-basal direction so that a continuous necrosis of the diameter of the brain appears which extends from the spot where the bullet enter- ed to the cerebral surface on the other side. Deflections of the bullet occur particularly with gunshot wounds, with the missile remaining in the forebrain, when the impact of the bullet is in the area of the base of the^skull (Sella turcica, Os petrosum), but also the spent missile which entered the brain from the forehead, hitting the vault of the cranium from within and rebounding from there at a corresponding angle into the brain. Thus nearly always.we are dpaling with depressed skull fractures due to gunshots. 179 It is only in exceptional cases that the particles of bone are thrown outward, as when the pressure of the explosion is directed to the outside, instead of being thrown violently into the brain and thus stick to the periosteum or are found scattered everywhere in the soft parts. The frontal brain has a marked disposition to swell to a degree which is other- wise found only with the vertex brain (areas of higher grade organization of the brain develop only late). Cerebral edema and encenhalomalacia. therefore, often spread in the area of the frontal brain very quickly and widely. Nowhere else does one see such masses of pulpy, or liquid-pulpy brain substance of a yellow color with a russet tone drain off as in cases of such injuries to the frontal brain where, because of the cerebral pressure in the area of the frontal sinuses or of the orbital roof, a drainage towards the outside had to be made some time after a primary inadequate surgical treatment or after conservative treatment. Only exceptionally did these softenings take place soon after the trauma. As a rule there was an interval of 2 - 3 weeks between the injury and the increasing softening. The results of healing were astonishingly good with simple softenings. Corresponding to the disposition of the frontal brain to swell, an inflammatory cerebral edema with brain abscess may very ouickly lead to considerable cerebral pressure which may occasionally become perilous even after the drainage of the abscess. the forebrain swells quickly it often shows the disposition to decrease quickly, so that the majority of prolapses under- goes involution. The removal of a prolapse in the area of the forehead is to be considered only if a subsequent closing suture is possible, when an abscess in the prolapse has de- veloped or if a better view of the interior of the brain can be obtained by a removal of the prolapse. Danger of an ex- posure of the anterior horns or chambers shifted in the dir- ection of the opening of the bone occurs only rarely in the area of the frontal brain. Pneumocephalus developed frequent- ly when the frontal sinus, the sphenoidal sinus, the tympanic cavity, the ethmoidal cells, or the mastoid^process were opened up. Intracranial accumulations of air in the fluid spaces or in the brain itself in case of fronto-basal injur- ies are generally the consequences of an involvement of the frontal sinus". The air gets into the chambers either direct- ly or indirectly by way of the basal cistern (cisterna chias- matica and interpeduncularis), through the foramina Luschkae into the fourth ventricle and from there into the third vent- ricle and into the lateral chambers. Distinct, spontaneous ventriculograms were frequently observed. The phenomena of such intracerebral accumulations of air are unimportant as a rule. Later on a periodical discharge of cerebro-spinal fluid or pus indicates a fatal complication. Often the air was reabsorbed only after days and weeks following the clos- ing of the dura gap and a corresponding treatment. An.in- crease of pneumocephalus indicates a closing of the valve or a progressive decay of the brain. Fluid fistulae. in the area of the forehead sometimes closed spontaneously. In conse- quency of the upright carriage of the head in supine posture the fluid discharges rather in its natural direction if it finds an open passage there. Danger of meningitisafter ex- posure of the otherwise healthy frontal and sphenoidal sinus, as well as the ethmoid bone cells, is, with a fronto-basal gunshot wound which was operated on in time, greater than with other injuries of the brain. Surgical treatment assist- ed bv sulfonamides brought about an"important improvement in this field. Healing of serious meningitis usually takes one to two weeks, sometimes rapid recoveries occur. Large doses of S (sulfonamide) are required (see WILDEGANS: Die posttraumatische infektioese Meningitis / On post-traumatic infectious meningitis, Chirurg 1943,14/). Directions for the treatment of fronto-basal gunshot wounds affecting the accessory nasal sinuses and their sequelae. In all cases of injuries to the face and head, partic- ularly when accompanied by unconsciousness immediately after the injury a fronto-basal injury to the dura is to be reckon- ed with. During transport the danger of aspiration is to be prevented by a suitable position of the head (dependent and turned on the side). The aim of the surgical treatment is to prevent infection of the wound in the brain in the sub- dural area, and the fluid spaces. A primary infection of the wound in the brain is to be overcome by a radical removal of all particles of brain, blood and foreign bodies, a secondary infection by the water-tight closing of the dura opening. The following measures have been particularly helpful; Closure of orbital tissue, pedunculated or freely transplanted galea- periosteum flaps, free transplanations of fasciae from the upper part of the thigh and prepared amniotic membrane. In case of fronto-basal injuries to the brain an ap- propriate treatment of infected accessory sinuses, which re- quires a thorough familiarity with rhinologic technique is just as important as the treatment of the wounds in the brain, which has to conform to the above mentioned principles. A careful and technically correct treatment of the accessory sinuses is of decisive importance for the prevention of ad- ditional infection of the wound in the cerebral dura during the healing process, and of even greater importance for avert- ing late complications. If a primary treatment of the wound in the dura is no longer possible or no longer required, a surgical treatment of the accessory nasal sinuses must not he neglected. The infected wound in the brain is to be treated surgically according to general surgical principles. In case of threatening or actual meningitis a complete meningitis treatment (sulfonamide-treatment, previous aspiration of fluid) has to be undertaken. uelao« 181 VII. PROCEEDINGS OF THE CONSULTANT? ' COMMITTEE ON GENERAL HYGIENE AND TROPICAL HYGIENE Translation prepared by; U. S. Naval Technical Unit, Europe, (Medical Section) Office of the Naval Advisor Office of the Military Government (U. S.) A* The effect of Gesarol and. Gix on flies. Anopheles and Phiebotomes mosquitoes• 1_. The use of Gesarol and Gix. Oberstarzt (Colonel* MC.) Prof6 ROSE The need for a discussion of the effect of the new agents for disinfestation is shown as follows: The group of agents for disinfestation, which are de- rived from Pentachlor-diphenylethane, are agents, which, through their unusual method of action in the different phases of the defense against contagious disease, have pro- duced revolutionary changes. These are agents, which poison the vermin by contact with their ventral surfaces and which are absorbed through their tarsal joints. They are elective nerve poisons with slow but certain effect. In consequence of their low rate of volatility and insolubility in water, they are characterized by an as yet undetermined permanent effect after only one application. Therefore they bring us a prolonged protection for dis- infestation, instead of the effect being temporary and of short duration as with all the previous measures taken again, louse infestation. If skillfully used, they offer a protect ion against the spreading of lice among the troops. This method of disinfestation for civilians, which has previously been technically impossible, can now be executed on those groups of people, who are chronically infected with spotted fever and are backward in civilization. The extermination of spotted fever has been approached even in the backward areas by the systematic use of these agents. In spite of that the troops must be fully informed about "Lauseto" being used only against infestation with lice and that they are safely protected against an epidemic of spotted fever. Be- cause of the slow effect, however, no complete protection is given against occasional infection by contact with spotted fever among the infected civilians. In order to avoid dis- appointment, we wish to point out, that single cases will remain until the method is applied among the civilians. In combating spotted fever, the agents mean an extraordinary saving of material and workmen in the establishments for dis- infestation. They make an extensive decentralization possible as they may be used by the troops under the most difficult conditions. As regards those diseases spread by mosquitoes and other blood-sucking insects, the new agents provide an econ- omical possibility for a well planned, treatment of the dwell- ing so as to eliminate the infections acquired in the house partly from human beings as well as from insects. VTe gain thereby an additional resourse of such great importance, that in my opinion it excells all our other preventive measures. 183 These new agents make the execution of the principles of complete disinfestation possible. The destruction of the agent of disease in the surroundings of the sick persons is now possible even in epidemics where previously the well planned execution of disinfestation seemed to be impractic- able from the technical point of view. 2. Introductory speech concerning the development and character of the disinfestation agents Gesarol and Gix. Stabsarzt (Captain. MC.) FINGER Gesarol and Gix, as well as the agents used for im- pregnating cloth against lice, such as Lauseto, Multocid- Duolit, contain a so-called Gesarol complex as the effect- ive substance which is in its synthesis covered by the patent of the German Reich dated 26 November 1943, for the benefit of GEIGY A.G. Switzerland. This agent is an organic combination, which is produced by the condensation of chloral with chlor-benzol and by which the replaceable hydrogen atom in the para-position is substituted for a chlorine atom, (Pentachlordiphenylethane)• The greatest advantage of these agents for combating animal vectors is in their lasting ef- fect, which has been sought for but has never been gained previously. In general their effect is that of a contact poison. The further protection of the troops by these^agents depends on the distribution of the necessary raw material, which is very difficult to get as it is used for other im- portant war purposes. 3js Report of laboratory experiments with Gesarol. Regierungsrat (Government Counsellor) EMMEL The experiments done in a laboratory with the Penta- chlordiphenylethane preparation called "Gesarol” dealt with the method of the action of this chemical substance on Anopheles and compared with Aedes, Culex and Musca. The results of the investigation concerning the manner in which Gesarol is effective indicated that for practical purposes the effect with Anopheles resulted from direct con- tact with the Gesarol coating. It is sufficient if the Anopheles merely touch the poison with their Tarsa (hair of arolium). Quite weak visible reactions with a long incubat- ion time have been demonstrated to arise from a Gesarol-de- posit for some distance at 22 to 33° C. (Gesapon 2 per cent and Gesarol spray-mixture 4 per cent). Gesarol does not seem to give any kind of warning in the usual way. Anopheles mac. and Aedes aegyptil suck the blood through a Gesarol soaked gauze. Flies (Musea dora.) seem to notice Gesarol even less. Anopheles may, however, escape the further effect of Gesarol due to a fleeing re- action which is compulsorily put into action, if the motor excitement caused by the poisoning effect is active. We drew the conclusion from this, that for practical purposes, all areas in the room suitable for the Anopheles to settle down, must be treated. If the effect of the poison is interrupted, a con- siderable percentage of Anonheles die. The ones which re- cover lose their legs and are no longer to be considered as vectors of malaria. Six different stages of poisoning have been different- iated on Anopheles. T'Tith the help of them we are able to draw effect curves by testing the effect of different con- centrations at different temperatures. Low Gesapon con- centrations (o.5 and 1.0 per cent) with only a few active particles per surface unit, are effective even at 31 de- grees, death occurring after about 23 - 25 minutes. Strong er concentrations (1.5 and 2.0 per cent) are less depended on the temperature as regards the rapidity of the effect and the curves generally show a more constant course. 2° the average, death occurs after 30 minutes, while the f:. manifestation of poisohing is notable af■er 6-9 minutes Besides the concentration, that means the density of the active substance per surface unit, the form in which the active substance has been distributed is decisive. Gesarol in the form of crystals is less rapidly effective and seems to be less readily absorbed. ]rhen the active substance is finely distributed, as occurs by the use of the emulgent Gesapon, it is absorbed much more rapidly and in addition it seems to be better absorbed. No quicker action can be obtained with a stronger suspension, but with a stronger emulsion which, in addition does not loose its potency even at temperature of 3° C. The death of Anopheles will be obtained with a 2 per cent emulsion after about 30 minutes and with a similarly concentrated suspension after about one hour and 40 minutes. In some cases Gesarol re- sistance has been observed in Anopheles. This suspension spray-mixture is not suitable for impregnating the nets for gnats in contrast to the emulsion of Gesapon, because it breaks off the web easily after drying. Undoubtedly, Gesarol, which possesses a longer last- ing effect has opened a new way in the field of combating Anopheles mosquitoes in the sense of malaria disinfection owing to its special use in the treatment of interiors by a deposit on the surface. 185 iL Experiments In laboratories and in the open air to test Gesarol and Gix on insects. Anopheles and Phlebotomes mosquitoes. Sonderfuehrer (Special Consultant) MAYER The examination of the effect of the preparation Gix on Diptera showed a high sensitivity for gnats, Anopheles, Aedes and Culex to its insecticide effect. The insects Musca,^Stomoxys, Fannis and Drosophila have been found less sensitive. The cockroach Blatta was only slightly affected, while the cornbeetle Calandra was not affected at all. Be- sides Diptera families, such as Culcides, Muscides, Bor brides Sepsides Phorides, Stratiomyides, Sciarides and Psychodides (Phlebotomes) as well as Coleopteres, to a lesser degree Hymenopteres, Anachnides, Myriapodes Permaptera and Lepidop- tera have been slightly affected. The agent thus has been found poisonous for a great number of insects, which are hygienically important. The agents act as a contact poison and as a gas. In- sects and gnats die after touching an impregnated surface for a period of only 15 seconds. The insects also die, if they only remain in a closed room and don’t touch any im- pregnated area. ✓ The agent used as a spraying agent shows an excellent effect when applied in a ratio of 1 cubic centimeter of 3 per cent solution per cubic neter. The robms into ' :f* which Gix has been sprayed, retain their toxic effect on insects for quite a long time. The more porous the sur- face and the warmer the room temperature, the shorter the effective time will be. The duration of the toxic effect may be prolonged by adding slaked lime. Porous surfaces cause a dilution of the agent on the exposed surface. Therefore concentration of the emulsion is not so import- ant for the effect as the actual amount of the agent per surface unit. A more pronounced evaporation of the agent is caused by the rising temperature, whereby the effective time is decreased. The testing of Gix emulsions showed this unlimited stability in our climate. Besides these factors the nature of the solvent is also of considerable importance as has been proved by the testing of two batches, which acted very differently as to their physical behavior and to their biological effect. The experiments carried out in the open air near Berlin and in the southern districts confirmed the results obtained in the laboratories. In warm countries the ef- fect depending on the material conditions of the treated wall, has not been of the same duration, as in moderate climates. Gesarol used as a spraying agent did not show such favorable effect as has been obtained by the use of ’’Schweinfurtergreen” for combating larva of Anopheles. When diluted with dust, even the mixture proportion of 1 : 50 has not been sufficient when testing it as a spraying agent. Hereby an emulsion with oil and en emulgent has been used. Benzol was used as a solvent. Emulsions pro- duced with Gix showed the same results. Both the agents increased the larvicide effect of the oil, so that in com- parison with pure petrol a saving of 99 per cent has been obtained. The results required, however, a confirmation by open air tests which will be carried out; this year. The agent Gix may be used as a varnish and a spraying and impregnat- ion mixture with good results for combating the troublesome insects. Hospitals occupied by fever patients have to be provided with screens as the agent cannot prevent the to and fro flight of insects. It may be specially indicated for the treatment of winter quarters, to protect against culi- cides in those districts infested by gnats. The same effect is to be reckoned rath when Gesarol is used. Comparative tests carried out on Gesarol and 'Gix show a slower effect of Gesarol, 5* Field tests of the effect of Gesarol and Gix on insects. Anopheles. Phlebotomes mosquitoes. Stabsarzt (Captain, MC.) KRUEPE By tests made with Gesarol and Gix based upon the ex- periments conducted in laboratories by EMMEL, the usefulness of this new contact poison for insects was tested in regard to its effect on adult fever gnats under natural conditions. In malaria infested districts of Greece, tests with the available trial quantities were carried out in 75 billeting- rooms located in stone houses or wooden barrack's, part of which provided with wire screened windows, 104 open troop tents and 711 bednets. Only watery preparations were used, mostly in the concentrations indicated for use on sur- faces, in a ratio of 0,8 to 8 grams per sauare meter, some- times also in a ratio of 16 to 33 grams per square meter. The watery preparations, mostly of 1 to 5 per cent and exceptionally also of 10, 15, and 20 per cent were generally prepared only a short time before their application, and were sprayed on all surfaces of the accommodations. which were accessible to the insects, using pressure spray pumps (Weinbergspritze), with a medium nozzle adjustment. 1 liter was always used for 6 square meters of surface white- washed in brick- or clay houses of unpainted walls or tent walls are less suitable. For a room with a surface of 120 square meters, nearly a quarter of an hour is renuired for spraying the necessary 20 liters of solvent. The bednets had been impregnated with these contact poinsons by dipping them into the freshly prepared solvents. After wringing them slightly they were dried in the open air. One liter of the solution h€is been used on the average. By applying a solution of’l - 3 percent, 10 . 30 grans were taken for one bednet or 2 - 6 square meters. The odor of the agents - Gix smelling slightly stronger than Gesarol - lasted only a few days and was never felt to be disagreeable or uncomfortable, A slight irritation of the mucous membrane in the throat and of the conjunctiva was caused during the spraying of Gix, A slight cough and watering of the eyes followed for one day. After the water has been evaporated the occupants had no more trouble# It has never been observed that these agents have poisoned persons or damaged furniture, clothes etc. The field experiments so far carried out, conformed more or less to the subtropical conditions of Greece. The elective contact poison properties of Gesarol and Gix af- fect fever gnats and flies under natural conditions, as has already been shown by laboratory test. The properties re- mained1 effective for a period of 3 or 4 weeks. This applies particularly to the treatment of rooms in stone or wooden horses, in which after a single treatment of the room the insecticide contact poison effect con'd be observed until the 25th day, and that independently of the concentration in the range of 0*8 to 8 grams per square meter# In tents, however, a remarkable relation of the lasting effect to tr' concentration could be observed# The surface concentration from 16 to 33 grams per square meter had a similar lasting effect of 18 to 20 days, while concentrations of 1.5 to 4.5 grams per square meter were effective for 2 to 4 to 6 days only. The reasons are probably the shaking down of the spray from the tent walls caused by the wind, especially of the powdered Gesarol which adheres poorly to the walls and further by the early ineffectiveness of the active substance , caused by the high temperature due to the sunshine on the tent walls. In contrast to the laboratory tests, the latent period, that is the time between the first touch of the insects leg with the poison covered surface and the appearance of the poisoning is relatively long as well as the total period including the different stages of poisoning suffered by the insects prior to their death, during th£ very hot sum- mertime in Greece. Gesarol has an insecticide effect, which kills flies after about 2-4 hours, Phlebotomes after about 3-5 hours and Anopheles after about 8-10 hours. Some of the insects were found dead only after 24 hours. Generally the strength of the effect was gradually reduced after the second week. This was deduced^from the prolonged duration of the different stages of poisoning. Generally the oily preparation has a more rapid effect than the powdered preparation of Gesarol, while Gix has a more insecticidal effect than the emulsified Gesarol. It seems as if the oily solution can be absorbed better by the Tars' of the insects than the crystalline form of the active part- icles. The various latent periods for the contact poison observed with the different insects are probably due amongst other things to the different metabolic situations of the day and night insects. The bednets for mosquitoes and rooms treated in this way, remained perfectly free from Phlebotomes for 3 - 4 weeks, an observation, which has been confirmed by Stabs- arzt (Captain, MC.) Dr. MUELHENS in October 1943 on the Isle of Crete. Warning effects by Gix and Gesarol on in- sects and Anopheles have, however, not been observed with similar clearness. Dr. MUELHENS has observed by his experiments that even a few minutes contact with the poison covered surface is sufficient to kill the Phlebotomes even though they had al- ready left the poisoned surface. During experiments carried out in the fields, it could not be ascertained how long this deadly effective time of contact lasts on insects and Ano- pheles, after they leave the rooms treated with Gesarol. It is believed, however, that the insects, having the possib- ility of flying to and fro in the rooms and tents, not pro- tected by wire screened windows, have been killed by the ef- fect of the poison outside the rooms, even in districts with great plagues of gnats and insects, where the inhabitants had already reported the increase of these insects. The kitchen rooms have not been treated. For the use of Gesarol and Gix by the troops in the South-east, the fol- lowing practical conclusions can be made: 1• Protection against malaria for the troops. By the use of the new insect contact poison there is a possibility of keeping the rooms permanently in such a condition as to kill the Anopheles right at the place of malaria infection, Particularly at^night these Anopheles get in contact with human beings in- fected with malaria, who serve as their blood donors. The Anopheles should therefore be killed immediately at the place of contact. This is a good way to obtain an effective malaria disinfestation in malaria district, especially in military hospitals, sickbays, billets foi troops and in the native houses of the neighborhood where parasite vectors as well as malaria infected people might be living. For medium sized rooms of about lg€) square 'about ’1*2 to 2.4 kilograms are mefhoay by the use of poison gas (hydrocyanic acid, tritox, Jllp' or sulphur dioxid) carried out by well trained troops for vermin control, or by the method of spraying, which is an emergency means for disinfestation. Gix must temporarily be reserved for combating Anopheles and Phlebotomes. Daily airing and exposing the bedclothes to the sunshine is. ad- visable. Reports on respective experiences will be forward- ed by courier to the hygienist in care of Admiral of the Aegean, whose office identifies the transmitted fleas and examines samples of the room-sweepings picked up from the floor fissures. These samples, like fleas, keep well for practically unlimited periods if kept dry in test tubes. Combating bugs in the field and in the homeland* Sonderfuehrer (Special Consultant) Dr. ECKSTEIN At first attention is drawn to the fact that the dif- ferent disposition to react often leads to a false im-» pression of the bug. Referring briefly to the cause lead- ing to the present condition of combating bugs, the dif- ferent methods of combating are briefly discussed in connection with the interesting details as to the life of the bugs* The importance of wooden houses for the propagation of bugs is specially referred to and it is shown that overheating of the rooms makes the use of sulphuric acid evuupL more difficult. It is demonstrated that the close living together in the crowded cities leads to a higher danger of the spreading of bugs in these areas. 213 The constant moving of equipment is of particular importance as regards the spreading of bugs in the billets. The measures to combat the bugs should therefore also ex- tent over the most important sources of infection. As the beds built into the walls of the barracks make combating of bugs even more difficult and favor the pro- pagation of bugs, the beds should never be built in. All useless boards have to be removed and a greater tidiness in the barracks must prevail. As we are not able to destroy bugs with good results every where and under all circumstances, methods have to be examined which are likely to give independence from gases which are difficult to procure and use. It is important to arrange a well trained organization to combat bugs at home as well as in the field. As the viewpoints of individuals with regard to bug combatihfe is often wrong, particular attention has to be paid to a comprehensive and general enlightment of the Armed Forces. This is of particular importance at home, in order to have the ground well prepared for legal measures to be taken in the time to come. Discussion: REICHMUTH: The gap between gassing methods and strewn agents must be bridged over for combating bugs under the present circumstance. This was achieved by ’’Atota-compres- sor dust method", which has proved to work well as was shown by laboratory and practical results. This method is suitable for such rooms as are provided with electric connections or with bottles of nitrogen and it has already shown good results in large barracks and in all those rooms, which cannot be made tight. The best prospects for success ..in combating with con- tact agents is now offered by ’’Room prophylaxis”. The conditions for the application of ’’Room prophylaxis” are based on the sensitivity of the bugs legs, on the effect of the distribution of insecticidal agents and on the toxic effect previously observed in Gesarol, diphenylamine and other chemicals. These experiments do not exclusively concern the de- velopment of insecticide, but their further object is, to study the effect of dispersion produced by various emuls- ions and suspensions upon substances with different poros- ity. Furthermore it will be examined how far the partic- ular object of room prophylaxis can be realized, especially in combating bugs by adding a mixture of the different in- secticides to chalk or oil paint. All previous investigations carried out in laboratories seem to justify the hope that room prophylaxis can be ex- ecuted by means of insecticide paint and therefore the practical application may be expected in the near future. KRUEPE; Two rooms of a wooden barrack infested with bugs were treated by me with 2 grams of emulsifiable Ge- sarol* In one room stood fixed beds and in the other self- built wooden beds. After 5 days the soldiers were still suffering from bug bites. The observations were not con- tinued after 5 days. It may be that after the time of my observation the bugs still came out of their hiding places, so that the immediate effect observed on fleas and gnats was not produced in the case of bugs. MUEHLENS: I was able to destroy all bugs with Gesarol in a large sleeping room tiled with stone slabs and furn- ished with iron bedsteads. The bugs lived in the mosquito- nets and in the mattresses. The fumigation with Gesarol was conformed with spraying guns and motor compressors. In barracks and native huts shingled with wood, reed and clay, Wiich infested with bugs, I piled all the clothes and equinment of a squadron in one room and fumi- gated it with Cyclon B in an emergency. The huts were scrubbed and sprayed with a cresol solution, the walls whitewashed and by this method the huts were almost free from bugs. ROSE; A discrepancy was observed in the reports con- cerning the first test with Gesarol, MUEHLENS has obtained good results, while KRUEPE did not observe any effect. Comparing these two statements it appears that MUEHLENS has fumigated the walls while KRUEPE only sprayed the walls. This is probably the reason for the different results. ECKSTEIN; The failure of tests with products similar to Gesarol for bug combating is often only illusive, since the destruction of bugs needs a certain latent period and will become effective only under certain circumstances, sometimes only after 10 days. Such a delayed fatal ef- fect will in most cases escape observation. LAUN; The use of Gix for combating bugs is not to be recommended, as I know from my experiences. The barracks* walls being sprayed with Gix showed no success, even bugs sprinkled with Gix survived. KLIEWE; Motor driven devices for disinfecting, dis- infestation and detoxicating purposes have been demonstrat- ed • EMMEL; I know several cases where the kennel of dogs were covered with fern-leaves for combating the flea- nuisance when no other products were available. W© had the impression that dogs did suffer less from fleas when the fern-leaves were renewed more often. LENZ; The question concerning the biological combat of bugs by spider has lately been proposed again. On the strength of my Information and of my own observation's in Greece I am convinced that the spiders in practice are of no special importance for combating bugs. In the South East there are several kinds of spiders which attack' and suck the bugs, but don’t search for them in their hiding 215 places. Only if the bugs were chased systematically, the snider play an important part in their destruction. Be- sides, sucking a bug takes quite a long time. It would be necessary to breed a certain amount of sniders in order to have good results. The possibilities of this method are thus very restricted. TaRTLER: Is there any nroof that cockroaches extermine bedbugs? By coating the walls and furniture with a mixture of cattle gall and chalk good results have been obtained in my military district. A definite judgement cannot yet be given, but it would be worth while to gather all exneriences. ECKSTEIN; Cockroaches only eat bugs in case of need. Cockroaches and bugs don’t exclude each other. That does not mean that they live in the same rooms. Bugs like to live in dry places, while cockroaches prefer damp places. It is possible to find bugs in one corner of the room and cockroaches in another. 14, Immunization against diphtheria and scarlet fever. Introduction• Oberstarzt (Colonel. MC.) Prof, ROSE The immunization against scarlet fever and diphtheria has been recommended except for a few restrictions by the consultant hygienist on the occasion of the third conference. The directions for use are given in the Report of the third Conference of the Special Medical Consultants, Section VI, Article 4, The results of the recommendation given at that time have to be checked after on year. A desire was ex- pressed especially from the clinics to be acquainted with the gathered results of the immunization. Furthermore we have to check whether the technical recommendations given one year ago have showed good results or if a modification is necessary. It is of great importance to answer the question whether the immunization affords anv provable pro- tection or not. The burden placed on the troops and on the medical service by every immunization lg bonsiderable# Im- munization reactions cannot be avoided even if utmost care is used. The advantage of the immunization must be estab- lished beyond doubt or has at least to be made plausible to .iiake us accept the responsibility of a compulsory im- munization of the troops. The psychological indication to immunize only to be sure that nothing was neglected cannot be considered sufficient, considering the difficult- ies involved for troops and the medical service. The value of the immunization against diphtheria has been established in civilian medical practice by shifting the age level of the nersons suffering from diphtheria. In the case of scarlet fever a similar advantage has not yet been proven. During the resettlement of the German popul- ation from foreign countries the immunization against scar- let fever appeared to be the principal advantage of a clear- ly recognizable reduction of scarlet fever mortality rate of two and a half times. 2Sli Present experience in prophylactic Immunization against diphtheria and scarlet fever. (Experiences of the Army). Oberfeldarzt (Lt. Colt. MC.) SEIFFERT The after-effects of immunizations which often occur in prophylactic measures against diphtheria are divided into primary reactions caused by the injection and second- ary effects caused by bacteria. The reactions of the first group usually corresponds to the reactions caused by other immunizations. However, they are different in the respect that they show a higher frequency of phlegmons and abscesses. The latter are considered to be specific- ally allergic and resemble the Arthus phenomenon. The incidence and rigour of the reaction increases r,ith the age of the immunized people. By appropriate dosage the reaction may be reduced to a tolerable degree. The aver- age reactions to the immunization are such that there are no objections against the immunization of adults. The secondary reactions caused by bacteria are more serious and often appear cumulative and may lead to seri- ous diseases and even to death. Instances are quoted. It is characteristic that haemolytic streptococci■have always been found in these cases. Classifying these bact- eria it was found that the same bacteria were consistently present in each abscess following an immunization. They are probabljr injected into the bodv with the serum. The contamination of the serum is usually due to the fact that the personnel who administer the immunization are suffer- ing from angina or catarrh. In particular cases of injury due to vaccination the streptococcus may have been inherent in the immunized personnel. A localization of streptococ- cus is possible at a place where the immunization took place and is favored by the local damage of the tissue, which may produce toxoid and absorbans in allergic patients The damage caused by prohpylactic immunization against diphtheria differs characteristically from the reaction caused, by other immunizations. In order to prevent those secondary reactions, the persons have to be immunized with the proper dose and with special precautionary measures as to sterility. All persons suffering from angina and catarrh or even persons who are in contact with people suffering from angina and catarrh and scarlet fever should be eliminated from those administering immunizations. Great care has to be taken to administer an exact dose and in the mixing of the serum in tuberculin gyringes or with a correspondingly diluted serum. "Schick’* testing is difficult to carry out when mass-immunizations are made. It is not yet definitely clear whether toxoid (anatoxin) causes more serious re- action on elderly persons than "adsorbat" serum when they are used in corresponding doses. On the contrary its application may be more convenient for adults. No final results can be given as to the success of vaccination of the Army. But these diseases seem to re- duce and to be less serious. Immunization in case of ac- cumulated diphtheria which may be carried out without injuries (no negative phase) are not always successful. Diphtheria stops mostly by itself, when occurring in closed circles of persons and Hien carriers are eliminated. Even when carrying out the immunizations to a large extent a great number of diphtheria cases must still be expected under the present epidemic conditions. Immunized persons may bec'ome vectors and suffer from diphtheria which is dif- ficult to recognize. If a general immunization against diphtheria is carried out, one can only expect a partial effect of the immunization. A certain risk of immunization damage cannot be avoided. Through the army toodloal service a general immunization of the troops can be carried out. But before introducing it, the situation should still be cleared up more, as to which steps have to be taken in order to positively eliminate any immunization damage. If there is no general immunization, special groups of persons who are considerably endangered should be immuniz- ed by special order. The routine immunization of re- cruits under 18 years of age is recommended. It should be even more convenient to have these men inoculated by other non-military services before drafting them. The limited experiences obtained by the prophylactic immunization against scarlet fever are on the whole ident- ical to those obtained in the prophylactic immunization against diphtheria. It would be advisable to gather some more experiences on adults before introducing a routine immunization. Limited immunization should only be carried out by special order on groups of persons specially en- dangered. A general prohpylactic immunization of soldiers under 18 years of age should be taken into consideration. 16. Prophylactic immunization against diphtheria and scarlet fever in the German Labor Service. Arbeitsarzt (Medical Officer of the German Labor Service) SCHWARZ Since Autumn 1942 all registrants for labor service in the Reichs Labor Service were frequently immunized against diphtheria and scarlet fever when drafted. These two immunizations were made on different occasions and later on simultaneously. An inoculation against!typhoid- paratyphoid was then intercalated between the inocul- ations against diphtheria and scarlet fever. An effect of the immunization against diphtheria on men could not be observed during their labor service. The effect of the inoculation against scarlet fever was more favorable. The reason for the unsatisfactory result of the im- munization against diphtheria is due to the present short period of labor service and the long period reauired for the inoculation to become effective. The reason for the better effect obtained with the inoculation against scar- let fever,'carried out at the same time and under the same conditions, cannot be given as yet. In case of the diphtheria epidemic in community billets it is not possible to dispense with the immediately pro- tective inoculations, since they have a quicker effect than inoculation with adsorbatserum, which requires a long time to develop sufficient antitoxic immunity. The intercalated typhoid-paratyphoid inoculations bet- ween the two inoculations against diphtheria and scarlet fever did not show any disadvantageous effect on the im- munization against these diseases. 17. Experience with Immunization against diphtheria and scarlet fever in the 1st submarine training division. Pillau. Marlneoberstabsarzt (Lt. Comdr.. MC.) TOLK Due to the fact that sailors of 17 - 25 years of age live very closely together on ships such as "Robert Ley” or work under similar conditions in diving tanks, there was a much greater possibility of transmitting diseases before immunization against diphtheria and scarlet fever was in- troduced. (242 cases of scarlet fever and 35 3 cases of diphtheria occurred within 3 years.) In October 1941 1600 men were inoculated twice with 0.2 cubic centimeter within a period of 4 weeks. 94 cases occurred prior to the second injection while in the 3 weeks after the second injection only two persons suffered from this disease. The disease disappeared entirely. No com- plications due to the immunization have been observed. The examinations of immunized soldiers of the front flotil- las showed no infection during the year following. In spite of that as a result of the bad experience noted by CLAUBERG this sort of immunization of men serving in the Navy was forbidden. 1500 sailors were immunized with scarletina toxin in October 1942. After the third injection no case of scarlet fever was observed while some of those sailors who had not been immunized became infected. Encourared by the good results and the excellent tolerance observed to the immunization, a combined im- munization against diphtheria and scarlet fever was car- ried out in January 1943? at weekly intervals in the following order: Diphtheria 0.1, ecarlatox I, scarlatox II, diphtheria 0.2, scarlatox III. These immunizations showed no complications. After the third injection against scarlet fever and after the seventh week following the first immunization against diphtheria, cases of both diseases were entirely suppressed. 219 In Summer 1943 a combined Inoculation with diphtheria- scarlatox was carried out on two training divisions of the submarine service. In both cases scarlet fever was quick- ly and absolutely reduced. Of a total of 46 cases in 7 weeks after the infection of sailors of the first training division of the submarines, only 8 cases occurred between 9th week. In spite of these incidents, the im- munization must be considered a success. Among the sailors who were not immunized 15 cases of diphtheria occurred, showing the prevelance of the disease. In the second train- ing division of the submarines there were 37 cases of in- fection with diphtheria, but after the seventh week this disease disappeared entirely. Therefore, in June 1943 the Surgeon General of the Medical Corps of the Navy gave the order to introduce immunization against ', diphtheria and scarlet fever for all sailers serving in the Navy and in the submarines. The results of the immunization of sailors attending the course of instruction could become apparent even in the next group. Owing to the difficulties in get- ting the necessary serum, only 57 Per cent of men were im- munized before entering the next course. During this course only one case of diphtheria and none of scarlet fever oc- curred, while out of the 43 per cent of the sailors not im- munized 41 were infected with diphtheria and one with scar- let fever. 62 per cent of the Immunized sailors did not suffer from diphtheria or scarlet fever during the follow- ing course, while out of 38 per cent of the sailors not immunized 8 were infected with diphtheria and 2 with scar- let fever. This proves that the immunization is very important for sailors serving on board submarines, as immunization has shown very good results on 13 000 sailors up to 25 years of age. Immunization should therefore be adopted generally by the Navy. The immunization carried out on 45 000 persons shows only very.few'complications 'when • asepsis is Observed, if ■thennbyklis performed sterile,' -o since only 11 persons suffered from abscesses of medium size* Furthermore it was observed that the course of the disease was a very mild one among sailors who had not re- ceived the full course. 18« Immunization against scarlet fever and diphtheria among young "Luftraffenhelfer" * in 1943• Oberstarzt (Colonels MC.) Prof. ROSE ♦ A special group of the "Luftwaffe" (Airforce) con- sisting of personnel between 15 - 20 years of age who were not assigned to combat duty and were used principally to assist the older and higher trained personnel in maintenance of aircraft and anti-air- craft guns. The practical purpose of the immunization of the younger gpound force personnel of the Airforce was in the first place aimed at a control of the disease rather than of gaining scientific experiments. These would have re- quired a card file system to register the result of in- oculation and observation of each individual "Luftwaffen- helfer". The data reported by the surgeons of the camps show that out of 10 000 inoculated helpers about 44 became in- fected with diphtheria and about 39 with scarlet fever. 80*7 per cent of the diphtheria cases occurred before and during the immunization and 19,3 per cent after the im- munization, while 85.4 per cent of the scarlet fever cases occurred before and during the immunization and 14.6 per cent after the immunization. As regards the observation period, It can only be said that on the whole it was much shorter before than after the immunization. In contrast to the opinion of the chief of the div- isional medical service, the opinion of the camn surgeons Is altogether favorable regarding the results of the im- munization. Four surgeons out of eight consider the im- munization to be a specific success and that the cases nf infection after the immunization are disproportionate- ly milder than the cases occurring before the immunization. Before judging finally whether this was a successful or unsuccessful measure, the sources of possible error have to be discussed and it should be examined which factors are decisive besides the inoculation, in order to explain the obvious differences between the cases before and after the inoculation. Besides the insufficiency of the statistics concern- ing the neriod of observation, it should be pointed out that the figures given which appear to be precise and well founded are onlv the result of a simple addition of num- erous individual reports, which came from different sources and show many mistakes common to medical mass-statistics, namely incomplete registration, incorrect reports, erroneous diagnosis, and the many errors due to the individual manner of compiling the reports, discrepancy in the evaluation of the cases etc. The question whether the differences between the figures are only the expression of the fluctuation due to the season of the disease has to be answered in the nega- tive. The result gained by the inoculation is so uniform- ly and equally good, from the epidemiological point of view, that it is suspected that the progress is influenced by some other fact. This contrast was confirmed by the result of my experiments made on Germans during the re- settlement. I point out the fact that the service of the uLuftT affenhelferf! is different from the service of our training regiments and technical schools. The main problem in latter is to combat scarlet fever and diphtheria which occurrs epidemically. The "Luftwaffenhelfer" soon after their first training are detailed into small groups. Only in the beginning of their service are they concentrated into larger groups but in the middle and toward the end of their service they are dispersed in small groups. This should have a favorable epidemiological effect. The de- cision whether this large influence is due to the immuniz- ation or to the conditions of a life under enemy action becomes practically impossible, because the control groups |Jere not* available in contrast to scientif- ic experiments. I should like to warn you against attri- buting the extremely favorable course of the epidemic be- fore and after the immunization exclusively to the immu- nization. 220a Furthermore I also refVr to the fact that the nLuft- waffenhelfer" were at the beginning of their service still exposed to the contact with other pupils in the schools and with their sisters and brothers, while the source of infect- ion, produced by direct contact with other persons is much inferior, but not entirely eliminated, after they were draft- ed to the Airforce. The following 5 injections with adsorbat-serum were administered: On the first day the first injection against diphtheria, on the 8th day the first injection against scarlet fever, on the 22rid day the second injection against scarlet fever, on the 28th day the second injection against diphtheria, on the 36th day the third injection against scarlet fever. The reasons for not inoculating individuals or post- poning the inoculations ate the following: diphtheria in- oculation carried out in the school or in the Hitler-Youth before being drafted, having had diphtheria or scarlet fever during the two years previous to being drafted, local nec- essities, immunization against typhoid and paratyphoid being of more urgent necessity. Counter indications, such as skin disease (especially pyoderma) chronic otitis, encephal- itis, epilepsy and other general diseases of all kinds. In addition, the completion of the inoculation was deranged by transfers, assignments, furloughs and subseement drafting or discharge, drafting for the Labor Service, for the Army or as a leader for the Hitler-Youth, etc. 1 The reported number of immunization must be considered more critically, since the evaluation of the incidents (infiltration, abscess, elevation of temperature? scarlet fever, exanthem, psychogenic collapse, etc.) the subjective factor is of primary importance. The same kind of incidents were observed which has reported from the Army. 15L*—IfeciLements and smear-tests in diphtheria and sc a r 1 et fever. Oberarbeitsarzt (Medical Officer of the German Labor Service; FREITA_G The committee ras acquainted with the statistical data and it was considered justifiable to cancel the directions concerning partial isolation and bacteriological examination of the contaminated areas in case of diphtheria and scarlet fever in the German Labor Service camps. Investigations re- vealed that only 3 Per cent of diphtheria and scarlet fever cases and 12 per cent of the cases with additional diseases possibly be^influenced by the partial isolation - in case of diphtheria - and by the examination of the contamin- ated areas. The first mentioned percentage is very low, on the other hand the benefit of the troops with regard to per- formance of active duty and to the general organization is considerable if all measures of isolation and of examination of contaminated areas of troops are eliminated. Under these circumstances even a higher incidence of infections would be the lesser evil (sic). According to our experience the infection with diphtheria and scarlet fever remained limited to a small group of persons. The special importance of the clinical treatment of men in a unit suffering from diphtheria and scarlet fever is emphasized. Discussion; CLAUBERG; The fact that the injuries caused by im- munizations are no longer trifling meets with general ac- ceptance. The presence of hemolytic streptococcus in abscesses caused by immunizations against diphtheria are due to a break of asepsis. In view of the results caused by the inoculation against diphtheria which were contra- dictorily evaluated by the referees, the calculation of the theoretical probability is missing. The use of the extens- ive material in Berlin (Deutsches Aerzteblatt 1944, # 4) permitted the proof of the success with mathematical pre- cision. Attention was drawn to the hesitancy concerning the simultaneous immunization in the Army, which was ex- pressed at the last meeting. Although accurate tests re- garding the necessary and appropriate antigen quotas for immunization against scarlet fever have not yet been carried through, the importance of these tests is stressed. If new cases of diphtheria occur, examination of the environ- ment is considered unnecessary if the units have already been immunized. The question concerning paradoxical dis- sociation arises in the sense of an increasing incidence of the infection in non-immunized persons within the im- munized troops and it is recommended that this matter be cleared up. KROEGER: The following remarks seem to be relevant in connection with the arguments made by CLAUBERG. In the evaluation of the diphtheria results in the Service the application of the SCHELLING formula was not possible as the group of non-immunized persons was missing. As already mentioned by SCHWARZ all men were immunized unless they happened to be ill on enter- ing the service* Therefore another method of evaluation has to be applied and the conditions of the civilian population must be compared with that of the troops. The conditions of the civilians showed good results concern- ing the general epidemiology of both infections* The results in the Labor Service refer to about 900000 men who were immunized. These immunizations have been administered to adults, in contrast to the immunizat- ion of children mentioned by CLAUBERG. The directions concerning the simultaneous immunis- ation against diphtheria epidemics were given in April 1943 to the troops with the "Directions concerning medical service". The danger of sensitization are usually over- estimated. The Labor Service tried to prevent danger of sensitization by using serum from cattle and sheep as passive components of the inoculation. ROSE: The statistics made on the "Luftwaffenhelfer" are not sufficiently reliable to justify a mathematical evaluation. The exactness of the evaluation cannot com- pensate for the shortcomings of the original material* Besides, the control group of unimmunized persons is not available within the "Luftwaffenhelfer" as this immuniz- ation was carried out as a practical means of protection and not for scientific experiments. PETER: The control of the theoretically probable rate of success of the protective immunizations gives a false impression of security which does not exist because the numbers of persons unimmunized or immunized, are not exact. This is the case in almost all medical statistics during the war years, due to the extensive resettlements of the population. WAGNER: In order to prevent injuries caused by streptococcus it has to be remembered that streptococci are widespread seasonal agents. Schoolchildren may easily be immunized at the appropriate time of the year, while the time for immunization for troops and Labor Service depends entirely on the conditions of war and on military requirements. KRUEPE: Concerning the question whether injuries were caused by injection at the locus minoris resistentia, I should like to refer to the observations made by MB® that pneumococci have been found in abscesses caused by infections after injection of solvochin as proposed for the treatment of pneumonia. TOLK: Abscesses caused by immunizations Luer!s glass syringes should not be used for inoculation, be- cause the doctor as well as the medical personnel are able to touch the piston with the fingers so that^it is no longer sterile after once being used (observation in our own units). KREUSEH; Investigations of the surroundings are still necessary for military hospitals in which the danger of combined infections has to be considered. For instance, the mortality rate of spotted fever raises up to 15 - 20 per cent in case of mixed infection with diphtheria. It should be avoided that persons suffering from scarlet fever and diphtheria are together in one ward, as it is very likely that persons who have just recovered from diphtheria may be infected with scarlet fever, even if they seemed to be immune before. Instructions for immunizations against diphtheria and scarlet fever. To the instructions for immunization against diph- theria and scarlet fever given at the third meeting ’’East" the following supplements were proposed; 1. A general immunization against diphtheria and scarlet fever will not be recommended. 2* The leading medical officer has to decide in each individual case whether immunization has to be carried out or not. 3. The medical personnel who are very likely to be infected because of their work in the diph- theria-wards should be immunized only if the conditions of their immunity require it. 4. The serum has to be shaken thoroughly before each immunization is administered in order to mix the adsorbates in an equal ratio. 5. Immunization against diphtheria and scarlet fever can also be carried out with the mixed serum of di-scarlatox ”Asid” or ’’Behring”. 20. Pappataci fever. Introduction. Oberstarzt (Colonel. MC.) Prof. HOSE The treatment of pappataci fever and its vectors, the sandflies, was put on the agenda of this committee in to conclude the group of diseases common to countries with hot climates which are important in the areas in which the German Army has operated thus far. Though pappataci fever is a harmless disease^as seen from the point of view of the individual patient, it may cause considerable losses and impair the efficiency the troops at critical moments, when it sets in epidemic- ally. The practical experience of the three last years has shown that fighting the breeding-places of the sand- flies, as recommended in manuals, is pure theory not borne out by practice. So far, we know neither any re- liable means of fighting the larva nor any methods of as- certaining the breeding places suitable for use by the army surgeon. On the other hand the first experiments of indoor-control with the new contact-poisons f,Gesarol,r and rfGix" has yielded such excellent results that we may ex- pect a decisive progress in disinfection against pappataci fever through the application of these poisons. 21# On.Epidemiology and control of pappataci fever• Stabsarzt (Captain. MC.) MUEHLENS I Pappataci fever is a brief febrile disease of short duration encountered in countries with hot climates which has a favorable prognosis without any complications. It is important because of its epidemic occurrence among foreigners, its very high morbidity rate and its high tendency to relapses. Epidemiologically important is the vector, the phle- botomus pappatasii. In Crete the sickness rate of the single units varied between 0 and 90 per cent in 1942 and 1943. That 10 per cent did not fall ill though they were exposed as much as possible is not regarded as due to natural immunity. The soldiers who did not fall ill were rather generally not bitten by sandflies. There were never any sandflies in the mosquito-nets above their beds, whereas there were plenty of these Insects in all other mosauito-nets. The greatest number of sandflies are observed in old, narrow and dirty villages, where flat mud-roofs are pre- dominant, but new brick-buildings and barracks were soon infested with sandflies, even if they stood somewhat apart. In Crete the phlebotomus pappatasii occurs even at altit- udes beyond 500 meters. Units in villages at an altitude of 400 meters were affected with pappataci fever, even up to 35 per cent. Sickness rates (In per cent) of pappataci fever and influenza. Month Crete 1942 Crete 1943 Sicily 1942 Pappatacl Tnfl. Pappatacl ihfl. Pappatacl Infi.- January 0.60 0.47 _ 0.24 February - 0.60 - 0.75 - 0.25 March — 0.70 - 0.80 - 0.23 [April 0.10 0.50 0.04 0.98 - 0.19 I Lfay 0.76 0.58 0.44 0.54 - 0.31 June 9.05 0.70 4.17 0.39 - 0.51 July 7.75 0.38 7.39 0.14 - 0.63 August 6.69 0.17 7.7 6 0.11 0.30 0.48 September 3.91 0.28 5.48 0.08 0.54 0.34 October 1.20 0.20 2.60 0.11 - 0.30 November 0.30 0.30 - - - 0.25 December 0.10 0.40 - - — 0.2 7 225 Sicily has different epidemiological conditions and a climate slightly different from that of Crete, but these do not fully explain the great difference of the sick rates. The annual peak of the sickness rate generally occurs in June. Owing to cool weather in the Spring of 1943 the peak of that year shifted to July. The beginning and the end of the pappataci epidemics coincide exactly with the flying time^of sandflies. It begins at the end of May and lasts till October including the months with average temperatures of 20 degrees Celsius, and more. In Crete the dry and hot south and south-east are more liable to pappataci fever thaA the north and west. Units having snent but one summer in Crete were affected twice as much as those living in Crete for the second year. Con- trary to former notions immunity is acquired but only to a limited degree. With some units the percentage of re- lapses amounts up to 30 per cent. There was a proportion of 6200 patients affected the first time and 1261 relapses, 498 of which occurred within three weeks after the first attack and the other 772 within the same year. Relapses after short changes of station within the island or to the continent are frecuent. Some soldiers were affected as often as seven times. The term ”pappataci fever" is unknown to the Greek population and Greek surgeons, though the disease also occurs among the natives. The duration of the disease is reported to amount to 2-3 days generally. In Corsica a variety of the disease with a duration from 4-9 days is said to be prevalent. In southern Crete the duration of four days was predominant. Of 319 patients, 111 were ill for four days, 69 for three days, and 84 for five days. Control measures cannot be started directly against the etiological agent, since one can lay hold of it neither in man nor in the open. A certain mechanical protection against the transferring inject is difficult too and has not yet been put into practice. A disinfection in the in- sect by killing all the sandflies in sick-rooms, similar to the malaria-disinfection proposed by Oberstarzt (Colonel, MC.) Prof. Dr, HOSE, may be effective, even if not com- pletely successful. Regardless of other considerations something should be done fight the sandflies systematically, since they are a nuisance in the house and often disturb the night’s rest. If pyretheum compounds are used, it is most important that the upner parts of the rooms are adequately exposed to the vapor since the sandflies,with hardly any exception, sit directly below the ceiling in the upper sections of the wall, which is out of reach of the ordinary sprayers. Only by using vanor-generators can all the sandflies in the room be killed. It is often necessary to repeat^the application within the same night, since many sandflies will be new arrivals. Poisons retaining their effect a long time are more efficacious. Here, formalin and sol- utions of cresol, and best of all, the captured English preparation Malariol did valuable work. Since the intro- duction of the preparations Gix and Gesarol the problem of fighting the full grown sandflies is practically solved. Besides treating the walls and ceiling, the impregnation of the mosquito-nets is of importance, as otherwise the numerous sandflies Hitting in the nets escape. Sometimes the impregnation of the nets along will do. Mechanical protection is difficult, because the in- sects are so tiny. Particular attention should be paid to the danger of the insect’s entering from the adjoining rooms. The normal mosquito-nets with 17 meshes per inch .afford; protection'*. ~-Therflefc§s‘sdryet}idth^ofi$©fc&ea*is 26 ffceshes, but such narrow mesh materially impedes ventilation. For the time being, insufficient knowledge of the breedinr-places makes it impossible to kill the brood. Personal experiments to locate larva and chrysalix failed. General cleaning aiming at the destruction of all supposed breeding-places renuires enormous labor and pro- mises only inadequate results. 22. Recent experience with pappatacl.j£eyeiL1_jLy^ • aspects and treatment. Stabsarzt (Captain. MC.) Prof. HOMING As regards the clinical aspects of pappataci fever, the main problem is the suppression of the dubious and questionable diagnosis "Papp". It has been proved many times, that the diagnosis Pappataci is used much too^often. Th"5 s is dangerous, particularly in relation to malaria, and especially malaria tropica, which must always be care- fully excluded before the diagnosis nPapp" is made. An- other danger is that of overlooking the frequent vague in- fections of short duration, several of which have been epidemiologically defined. This was through reports of their appearance accumulated locally and temporarily and in making the premature diagnosis pappataci only to set one’s mind at rest diagnostically. On the whole by com- mitting oneself to the diagnosis pappataci, one will too easily set aside an unprejudiced the Pat- ient and an advance on fresh lines of scientific research. It is strictly required, therefore, that at least some of the following symptoms are manifested, before the diagnosis Pappataci is made; either the appearance of a group of cases locally and#temporarily, which renders the diagnosis relatively certain (such as in the case ge- nuine influenza) or? in the individual case; a quite typ- ical fever-curve, violent aching in the head and loins, conjunctivitis (so-called Pick symptom), no enlargement of the spleen, a moderate leukopenia, typical sandfly-bite. and scratches ‘caused by them. Only when at least 3 - 4 of the symptoms mentioned are present should the diagnosis be made. All other clinical symptoms are more or "less irre- gular. Even the long period of convalescence so often men- tioned applies but rarely. Despite the seemingly mild symptomatology the diagnosis can be made clinically, even in the case of Patients suffering from other diseases at the same time, e.g. malaria or typhus, pappataci can be quite satisfactorily discriminated from those. The question of immunity is difficult to answer, be- cause of the lack of efficient diagnostic laboratory-methods. It is supposed that the ostensible frecmency of relapses in the same season is largely a result of unreliable diag- nosis, as genuine relapses are very rare. On the other hand relapses in the following years certainly occur frequently. As regards treatment for pappataci fever, no measures are necessary other than treatment for subjective complaints. 23* Essential facts concerning the fighting of sandflies• Mar.-Reg.-Rat (Government Counsilloy. Navy) WEYER The sandflies which are limited to tropical and sub- tropical countries are injurious to health in many ways* They are of most practical importance as agents of Leish- maniasis. Within the Mediterranean region pappataci fever requires Particular defensive measures against the sandfly vector. The principal difficulties in fighting sandflies are their small size and their living in hidden places, be- sides the fact that we know relatively little concerning their way of life as compared to the more important gnats. But more important is the fact that their habits of breed- ing do not allow any intense activity against the larva since the larva does no live in water, but on the ground, in rubble, vegetable refuse, etc., where they are difficult to locate; are never found in large numbers in a narrow space, as the gnat larva in the breeding-pools, and do live where the effect of chemical poisons is prevented by mech- anical difficulties. The small size of the full grown sandflies allows them to creep though the meshes of ordin- any mosquito-nets, at least if they have been fasting. The detailed knowledge of the sandflies is limited, because of special considerations. They have no striking morphological characteristics, which might afford the basis for synoptical determining tables. We still know too little of the importance of single species as vectors. For this reason there has been no clear-cut mode af attack against the sandflies as yet. On the other hand we know that some species are of particular importance, owing to their frequency and habits of life alone. To this group belongs for instance the phlebotomus pappatasii, which is supposed to play the principal part in transferring pappa- taci fever within the Mediterranean region. Since the phlebotomus pappatasii is a particularly large specias, it is of practical possibility to differentiate it from other species. Lastly, our knowledge of the habits of life and Breeding••'r'f"'the-'sa&dflies'is 3till“ quite incomplete in many important respects. Owing to the various habits of life of the different species, supplementary observations, which are urgently needed and for which we have an opportunity now, are of practical use only if we are als0' able to different An*, iate the single species. For this reason, a modicum of systematic knowledge is indispensable even to the non-ento- mologist occupied with fighting sandflies. If a limited geographical ajsa'with onjjy a few iraore frequent species is con- cerned, such a person will even get along with slight rudi- mentary knowledge. He must be acquainted only with the prin- cipal features of the life habits of the sandflies and with the methods suitable in each respective case. Some import- ant characteristic features are illustrated by the example of the male hypopygium and the female spermatheca of phlebo- tomus pappatasil and phlebotomus sergenti„ 24. Essential facts concerning the biology and fighting of "sandflies. ~ Major Prof. LENZ Measures against a noxious insect must be founded on exact knowledge of its structure and its biology. Only in exceptional cases is it possible to fight the sandfly larva in mass breeding places. The insects generally occur in innumerable individual biotopes where they cannot be fought practically. In hot arid regions they find the high degree of moisture necessary for the first few stages of development of the larva only in deep wall-fissures and other deep small holes. The full grown insects can be killed direct by chem- ical means in their daytime resting places, in bedrooms, and stables. These daytime resting places are certain dark nooks situated chiefly in the upper part of the room. More efficient and easier is the use of the wall coating compounds Gix and Gesarol which retain their ef- fect for weeks and kill the sandflies more effectively. It is even more to the purpose to prevent the sandflies penetrating into the rooms by closing the windows with narrow meshed wire and to protect the sleepers by bed-ne s. The wire-netting must have a maximal width of meshes oi 0.8 - 1.0 millimeter, that is 24 - 27 mesches per Inch. Fabric gauze must have still narrov/er meshes or must con- sist of threads of strong fibre* Most efficient is the use of bed-nets, impregnated with Gix o* Gesarol, since they may have wider meshes, viz. are more permeable o air, and yet prevent the sandflies from penetrating through the warning effect of the impregnation. Discussion: HARMSEN: During the months from January to April we observed, particularly on the Dalmatian coast district, in all hospitals minor epidemics 6f infection, corresponding to the clinical picture of pappataci fever and some even reported as such. After a sudden rise of the fever to mor§ than 39° C,, the temperature will remain high for three or four days and then drop rapidly. The main symptoms are violent headaches, which virtually cannot be allayed, and conjunctivitis. In most cases there are no catarrhal symp- toms, no enlargement of the spleen and no typical finding of the blood. The feverishness was followed by a long state of exhaustion and slow convalescence. Malaria, spotted fever and so-called grippe infections could be positively excluded. Evidently it was a disease closely resembling pappataci fever, if it was not identical. There was no possibility of sandflies being the vector. Pappataci fever has been particularly frequent in the Dalmatian-Bosnian region for a long time and it seems probable that the virus can also be transferred by other means than by sandflies. HOERING: I once more warn not f© generalize about the diagnosis of pappataci fever. Similar infections, even if occurring in groups like that recently observed in Albania in winter, must not be diagnosed as panpataci fever. Three weeks after the close 6f the nanpataci fever season, several cases of pappataci fever were suddenly ob- served again in November 1943 in a hospital for tropical diseases at Salonika, after the heating system had been started when the nights became chillier. This had evident- ly stimulated some surviving sandflies to activity which were still capable of transferring the disease. WEYER: The problem must be whether the pappa- taci virus can be transmitted by the sandflies to the follow- ing generation and how the first few cases of pappataci fever are to be explained, and, lastly, whether other spec- ies besides phlebotomus pappatasii are involved in trans- ferring the disease in the Mediterranean region. X"e need further data on the occurrence of sandllie-., particularly of phlebotomus papnatasii, in order to determ- ine the northern boundary of distribution of this snecias. The data available as yet are incomplete and partly unre- liable. The dependence of distribution on the climate must also be examined more closely. ZSCHUCKE: In Istria three day!s feverishness will be followed by a 2 - 3 week’s convalescence with such violent nervous disorders (Headaches, insomnia, depressions, lack of appetite), that the diseased Italian soldiers are by policy exempted from outdoor service for several weeks. The ouestion arises, whether the same was observed with our soldiers in the region of the Aegean Sea. LENZi The fallacy of diagnosing pappataci fever during seasons when there are no sandflies is a well—kno'?Tn fact, and has been confirmed by my systematic researches, which showed that the first cases of pappataci fever are always diagnosed in spring, when the first sandflies appear, and that they cease in fall, when the sandflies disappear. During the whole pappataci period of summer the curves for freouency of sandflies and for the sick rate show the same tendency. As for the question of virus-reservoir in winter I have begun to make experiments with the objective of prov- ing the transmission of the germ to the next generation of sandflies. Though these experiments have yielded only ne- gative results so far, the possibility of obtaining positive- results in the end is not yet excluded, since the breeds available must be considerably increased and means must be found to work with larger numbers of patients. The pappataci cases in November mentioned by Stabsarzt (Chptsdiifl MC.) Prof. HOERING seem to be a further confirmation of the theory of a transmission of the germ to the next generation of sandflies. I regard them as the results of an infection caused by a second generation sprung from in- fected sandflies which propagated in the course of summer. This second generation was evidently forced to premature puppation and development into full grown sandflies by the heating of the building begun in November. The full grown sandflies then caused the infection. STELLWAAG: Wire-netting as"naniW ah required for pro- tection of the windows against the sandflies cannot always be supplied and in addition is disliked for its interference with ventilation. w© understand that even gauze with wider meshes impregnated with poisons like Gesarol may be used (which '"ill scare away the sandflies). On the one hand these preparations being scarce are not available every- where, and on the other hand the wire-netting is heated by solar radiation to such a degree that the effect of the poison will decrease rapidly (evaporation). But to repeat the impregnation many times does not pay. Perhaps an attempt at usine the gauze with wide meshbs' covered with glue to which the sandflies will stick would be worth while. Caterpillar glue may be dissolved in carbon tetra- chloride and sprayed on wire-netting. Since the sandflies alight on the gauze and then creep through it, a gauze with comparatively wide meshes might answer the purpose (even againtt culicides). A disadvantage of this method is that a gauze treated in this way readily becomes soiled, but even so it ought not to be difficult to clean it with a brush. Information leaflet on pappataci fever; 1. Pappataci fever (three-day fever or dog fever, other names should not be used) is a virus disease and is characterized by a fever rising rapidly after an in- cubation of 3-8 days, but dropping again on the second to fourth day, which is associated with very severe headaches (feeling as if the head was bursting) with^pain in the muscles, conjunctivitis, cyanotic fascies, anoresda and intestinal disorders# In most cases there is a remarkably pronounced relative brady- cardia. A leucopenia occurs, but there is no enlarge- ment of the spleen. The patients usually feel very ill, are freauently weak and much depressed psychically. Headches and giddiness will often outlast the deferves- cence by a few days. The average duration of incapacity for duty amounts to five days, the duration of post- febrile symptoms to a fortnight at the most. The prog- nosis is very favorable; cases with fatal issue pract- ically never occur. 2. The vector of the disease is the pappataci sandfly (phlebotomus pappatasii), a small (1 - 2.5 millimeter), greyish yellow gnat, hairy over its whole body. Char- acteristically it holds its wings at rest like an angel, which is different from other gnats. It dodges any attempt to catch it. Its bite causes violent itching and often violent reactions of the skin. The virus circulates in the Patientfs blood only dur- ing the first two days of the disease. It can be ab- sorbed by sandflies only during this period; the sand- flies in their turn can transfer it again to man by bite after a process of ripening and increase which takes 6-8 days. 3* The diagnosis has often been made even in regions in which the vectors do not live at all, viz. the disease' cannot occur. But even in regions in which the disease is spread, the diagnosis has been erroneously applied for short or even lingering infections, etiologicaliy obscure, though epidemiological considerations, season, and manner of occurrence positively excluded pappataci fever. 4. Before filing his report, the army surgeon should convice himself that there are sandflies in the area, without which the disease cannot occur, if necessary by consulting a hygienist or an entomologist. Among the present areas of operation the occurrence of sand- flies may be expected in the whole South-East (altit- udes exceeding 600 meters excepted) particularly in the coastal districts of the Mediterranean during the period from summer to early fall (from the end of May to September). 5. Under certain circumstances pappataci fever may af- fect large numbers of the troops within a comparative- ly short time and incapacitate them for duty, even^ if only temporarily. In the region in which the dis- ease is present,danger of infection exists, above all if the troops are billeted in towns and villages, since man will create places^for refuse there, which promote large scale propagation of the agents. Des- truction by war with accumulation of debris and rubble also creates favorable breeding-conditions for the sandflies. Tent camps will not be affected as a rule. 6. As regards differential diagnosis. malaria, particularly malaria tropica, must always be excluded first. In all events the thick smear must be examined with this in mind. On the 'rhole the diagnosis of pappataci fever is to be made chiefly by exclusion. Other infectious diseases in their initial stage (particularly those with conjunctivitis, such as spotted fever, smallpox* measles, dengue, even hepatitis epidemica etc.) and above all, the frequent non-characteristic febrile in- fections (Influenza) produce quite similar clinical Pictures. 7. Pappataci fever, once overcome, generally leaves behind a relative partial immunity. Relapses have been observ- ed even after a fortnight. Several relapses may occur. B. The treatment is symptomatic: bed-rest, fever diet, with possible use of antineuralgica (with hardly an:/ effect). Sulfonamides are of no effect. The most ap- prehensive patients should be calmed by pointing out the favorable prognosis. 9* The disease can be prevented through protection from sandlfy-bites. The normal mosquito-net does not answer the purpose owing to the small size of the sandflies. Only with at least 10 threads per centimeter afford any protection, but they considerably impair ventilation and passage of heat from under the net. The small range of flight of the sandflies (about 50 meters) may have the result, that, according to the situation, some rooms are violently infested while other rooms in the same building are not infested at all, and that in isolated houses, even sleeping on the roof will afford some pro- tection. 10. Particular attention should be paid to the protection of specialists (such as flying personnel, signal corps men), since their being affected by this otherwise comparatively harmless disease makes itself felt more than in other branches of the service, 11. Measures of defense: It will hardly be possible, as a "rule, to eliminate the breeding-places. They are to be found in crevices of the glound and the walls, at stables, in heaps of refuse, dung, and straw etc. They require a certain moisture and darkness. Mass- bfeeding places are destroyed houses etc. 12* The full grown sandflies can be killed in their day- time resting places in bedroomsand stables (dark, draught-proof nooks, mostly near the ceiling) by dir- ect spraying with chemicals (preparations containing pyrethreum, such as Flit, Detmolin, even diluted sol- utions of cresol or formalin). The method of using Glx and Gesarol as a wall coating is more reliable and easier, since they retain their effects for weeks. The most suitable method is the use of bed-nets im- pregnated with Gix or Gesarol (moisten the water and then immerse them in a solution containing 1 per cent Gix or Gesarol). 23 3 VIII. PJ5_0_C_E_E_D_I_N_G_.S 0J?_ T_H_E C_0_N_S__U_L_T ,A_ C. OM M I.T T E E 0_N_ INTERNAL MEDICINE Translation prepared by: U, S, Naval Technical Unit, Europe, (Medical Section) Office of the Naval Advisor Office of the Military Government ( U. S. ) 234 Present experiences.while carrying out immunizations a£ainst_di£hteria_and_.gcarlet_f eyer_Isee_Secti.2 Concerning the need of calcium in the f.opd of troops (see Section 14, Article 9) Ik Experiences in the formation of "Stomach battalions!1 . Prof, .yAFAL.\J?NHAUSElJ In July 194-3, a special unit for patients with gastric Complaints (abbr, "M-battalion") was first formed in the VIII. Military District, The reason for this was the in- creasing number of patients with chronic gastric complaints which led to an intolerable overcrowding of the internal medicine departments of hospitals and dispensaries. The "M-battalion" was to provide profitable employment with con- sideration of the special needs of these patients especially as to their diet and their assignments. At first, all military personnel ol* the military district under treatment with these conditions (L52) were examined by an experienced specialist to determine their fitness for the "M-battalionn, All those considered unfit because of a serious disease were discharged. The rest formed the nucleus of the "M- battalion" which was meant to be a training unit for the creation of field formations. In the long run it turned out to be useful to establish a special hospital for gast- ric complaints in Freudenthal where this "M-battalion” was stationed which was used also as a hospital for the recept- ion of patients with gastric and intestinal complaints. That meant that all patients with gastric and intestinal complaints coming back from hospitals to the VIII Military District were transferred to this hospital for a final of their fitness. Thus the increase in strength of the "M-battalion" was well regulated. The men of the M-battalion can be divided into two groups. Besides the small group who have only gastric complaints there is the other, much larger group, whose gastric complaints are overshadowed by other functional dis- orders and those oomplclDts are only one symptom of the sick individual. Previously these men were sent from one hospital to another and a great number of them never receiv- ed complete training anywhere. They are the type of weak plaintive individual who takes too gloomy a view of his com- plaints and constantly refers to them. It is the most im- portant task of the "M-battalion" to train these persons and to increase their efficiency as much as possible. The individuals with only slight gastric complaints and whose ailments are chiefly psychic will be treated by a psychothe- rapist. If he thinks them fit to be trained, they will stay in the "M-battalion" in spite of their slight gastric com- plaints, so that they will no longer be repeatedly haunting the sick bays and hospitals. Only those psychopaths who Cannot be trained are regarded as unfit and are discharged. The care and treatment of the MM-battalion11 has to be undertaken by an experienced internist who cannot be deceiv- ed by the psychopaths deceptions. Every man in the MM-battalion" is listed on a card in- dex of the army physician which contains all important his- tory and examination dates with the findings* record will be given to the accompanying army physician when the men are assigned elsewhere for service. The army physician divides the individuals into three classes according to thei:. respective fitness. The classes are formed into platoons or companies according to the number in each group and the only difference will be the duration and the severity of dutp The training course of the 11 F-battalions11 presupposes nothin, and will be held in two courses of six weeks for individuals and groups including all branches of infantry service. Observation of the weight is considered to be an im- portant factor for the justification of a sick reoort, If an Increase of weight develops during the treatment for a gastric o’omplaint, the latter will usually not be of much significance. Because of this fact, a great number of sick reports can be rejected as unjustified. Necessary medical examinations are to be carried out in th« sick bay 19 poss- ible, which is provided with all the paraphenalia required. On the one hand the patient must feel that the physician treats his complaints seriously, on the other hand he must know that occasional complaints such as pyrosis and a filin'- of pressure do not justify release from service. The ment- al attitude of all men of the,rM-battalionM has to be con- tinuously observed and supoorted by the unit nhysician and the unit commander. The success of the battalion depends ol. their personalities, It has generally proved a failure to select officers out of the group of men suffering from gastric complaints. The officers must have a proper under- standing of the balance between demands and efficiency and even when off duty they must take continuous care of their men. This duty will be too gr~at a strain for officers who are ill themselves. On the other hand, however, it is po- sitively astonishing what able and energetic officers can develop from their men. Such company commanders succeeded in making fit about 90$ of their patients for active service after a period of training. To guarantee a constant treatment of the men of the ”M-battalion" they must be prevented from gaining admiss- ion to other hospitals by reporting sick with other format- ions, especially during their leave. This was done by making an entry on page 12 of their pay book that in case the bearer reports as sick he has to be transferred to the special hospital at Freudenthal if he is able to travel. This measure materially diminished the freeuency of sick reports during leave. In the same way men requiring hospit treatment from active field units are sent back to the special hospital at Freudenthal (except for instance in of infectious diseases and wounds etc,) Even if sending t>;.. back to other hospitals cannot be avoided, it is urged by the entry in the pay book that they be sent to Freudenthal as soon as they can be moved. It is only in this way that a uniform and permanent supervision and treatment of the patients aan be achieved and this is considered to be one of the most important tasks of the special hospital 4 The advantage of the "M-battalion" has been evident in VIII Military District, You can observe everywhere a decrease of work in the dispensaries and internal medicine v/ards of the general hospitals in the home country as re- gards the men with chronic gastric comolaints whereas they used to be sent there again and again. The active units coming from the Freudenthal special hospital have proved very efficient. It must be stressed, however, that such a success is only attainable if the gradual training is done in the way described above, which aims at educating, training and leading the patient in a sympathetic but ener- getic way and to keep him in that special unit under any circumstances. This task can be performed only by officers who are not only able but also keen on this special task. Z*. iiSJismacii_Batialioi}»-^rid-diotarx>iSaintsnanco_.ln^thx: field pd jesorvo armyA J*£jtl.K4i£ES All men ?/ho suffer only temporarily from diseases such as enteritis, bullet wounds in the stomach} etc,, are not suitable for the MM-battalion'f . Only those men are to be discharged as unfit for active service v/ho suffer from that kind of gastritis which leads to a permanent in- fluence on the physical condition with a steady decrease of weight in spite of medical treatment. All men with ulcers are fit. They are treated, if necessary, in our special hospital until they have been thoroughly studied including X-rays and gastroscopy. It must be borne in mind that be- ing free from pain alone is no criterion of the ulcers being properly healed. Chronic ulcers which recur at short intervals are to be regarded as unfit. It is a special task of the ’’M-battalion" or rather of special hospital for gastric complaints to separate the diseases which are mainly functional from those which are mainly organic and to ascertain if possible the degree of activity with ulcer- ous processes. The differential diagnostic symptoms with a florid ulcus or a scar described in detail. It must bo borne in mind that the ulcer complaints may be the mani- festation of a fictitious neurosis which affects the inter- nal organs. This was emphasized by NOME, with whom I fully agree after my year of experience with the 11 M-battalion"# Especially suitable for the "M-battalion" are all those case with scars.’’ Even patients with stomach resections ’ ’Suita if the remaining portion of the ttomach is* largb'/ohdugh'the condition satisfactory and if only small in flammatory changes can be detected* Patients with-a small stump. requiring frequent feeding, and with serious inflammat- ions‘are to bo discharged as unfit, “The most important prit. cipld for admissioh•to decide tne- question, whether or n the efficiency can- be increased, $>r at least can the pain bo alleviated by, dieting* That is why patientp.uwith cholecyst tie-> gall-stones andy-inflamination of the bilepduct, dysente: are admitted* 'The dietpry supervision and treatment; important* V The troops get the food ration of group III, which contains 700 grams of bread, 4-0 grams of fat and 1200 grams of veget- ables and potatoes per day and 700 grams of meat per week. They get white bread instead of black bread. Because of the different kinds of patients in the battalion, as for instance with diseases of the liver, gastric and intestinal complaints and the indigestibility of artifical fats, artifical honey and jam, the fat ration was given as butter. Vegetables are usually prepared. Potatoes are served as mashed potatoes by adding milk or skimmed milk. This diet was given not only in the home country, but also to the troops in the field The necessary diet kitchen utensils such as meat choppers, potato mashers, pots and pans, sieves, bolters, griddles, ladles, colanders etc., are brought along from the former location. When sent on field duty the troops need additional medical eouipment besides "T.S.A.'1 (the normal set of Medical Supplies and Equipment for the Armed Forces), an X-ray appa- ratus (heavy) a scale and endoscopes, gastric tubes, etc. The units have to be fully" equipped with medical instruments and kitchen utensils before a battalion is sent into the field. The supply of the required medicaments must also be provided. It is necessary, that the army ohysician and the army officer make every personal effort to carry through ever measure contributing to the ultimate success. In spite of the physical strain of field duty the number of men suffering from ulcers has become much smaller than previously when they were on duty in the home country. The MM-battali onsprove that it is nossible to mobilize still larger reserve forces and this measure will at the same time be useful and advantageous to the patients themselves, ers„ co n_2 or ning_^M-battel ions KATSCH: Not every officer suffering from gastritis is capable of leading a stomach battalion. If he is able, how- ever, his example will be of great value. It is still difficult to find the right officers suffer- ing from gastritis for the stomach battalions. It has to be avoided that persons needing special diets being treated according to L 52 should be admitted to the stomach battalion Above all they are not to be kept for any length of time but are to be discharged as soon as possible (for in- stance after heoatitis, after a cecum operation, after her- niotomy) R GUTZFIT; The efficiency of stomach battalions has been variable when used for covering and mopping up operations according to their training in the home country and accord- ing to the consideration and security of the special condit- ions of the location of their activities. They were used successfully when an energetic and intelligent corps of officers as well as an able army physician trained and se- lected the men in the home country and where in the field the possibility of thorough medical supervision as well as the appropriate diet was maintained. The efficiency of the M-battalio depends absolutely on the fulfilment of these last two conditions. Tod hasty order for formation, insuffi- ciency of staff (cooks, medical officers, commander or tech- nical equipment. X-ray apparatus, instruments for stomach examination and treatment, field kitchen utensils etc,), prevent the efficiency as well as the distribution of the units over too wide an area. The rate of sick reports was about 10% of the men with a battalion on guard duty,of these only half of the soldiers suffered from gastric complaints. With a third battalion which was distributed over a larger area kilometers) the number of sick reports was much higher (up to 35%), The number of sick men depends further- more on the Dualities of their leaders or the commanding officers. Therefore should be assigned to the unit while it is being formed and they must be selected carefully* It does not matter much, whether they are suffering from gastric complaints or not, A general prohibition of smoking is not necessary, nor is a general exclusive supply with white bread. In one battalion only 50% of the men needed white bread. The prohibition of smoking and supply with white bread are therapeutic measures and are to be decided in each separate case according to its individual merits* SCHUERMEYER: In the Navy we have an experience of about three years with ’’dietary'* units. After a central ”M-battal- ion” has been established in the naval collecting hospital the Patients are distributed from there to the suitable units which provide the appropriate circumstances* The fitness for service of the patients has been increased materially and the number of sick Reports has decreased a great deal. The establishment of a dental clinic in addition to the diet kit- chen Is of importance. BAADER: The "M-battalion” of the VIII Military District stationed in Lille has stood the test well. SCHLUETER points out the difficulty of taking care of the ”M-battalions” by an army physician if they are used in an unsuitable way (e.g. guerilla warfare with the danger of being surrounded by the enemy temporari iy). UHLENBRUCH: According to the theory of the ”M-battal- ion”, those patients classified in the group L52, who are often psychopaths and disposed to depressions are to be imbued with a positive soldierly bearing. In the long-run, we ta’ e the risk that on the other hand soldiers coming from field units who have performed their duty previously without bothering about their gastric complaints (the achievement of men with chronic gastric complaints are often surprising) may use every effort to be sent back to the special battalion? This danger would increase if other groups of patients should be formed into special units. 2*- QU£ £ H a sX—iib£ i £ _ Bfi £ i1 n p s s _ f o r _ 3. q £ j. v§_ wax S£££,Us* eldar.zt_iLt^£^^MjtC^j^ProfJ,KATSCH_ Physical work is advisable for all kinds of trained diabetic patients with a reasonable attitude. They are healthy under certain conditions which does not always mean iiv, for service under certain conditions, at least not for a patients by any means. The dieting must not interfere w?+hm^h.Wlth the necessity of having their meals in common with their comrades. Slight modifications of the military etary would provide certain possibilities of extension anc selection. In the life of a soldier, the necessary regular- ity of meals, which is important for most diabetic patients, especially those under insulin treatment, is difficult. Physical strain after an insulin injection is apt to decrease the blood sugar considerably and even if no unconsciousness and convulsions occur, the consequences are not only redueed efficiency but include cerebral reactions like stubbornness, states of intoxication and frenuently violent Diabetic patients might be employed in special local units of the German Labor Service with a settled routine. Units for diabetic patients should be subject to static conditions. Their fitness for service would be more limited and narrowly circumscribed than that of a "M-battalion" kept to a certain diet. Such an organization is in general not to be recommend- ed , Patients affected with mere renal diabetes are fit for service. Some patients with slight diabetes who need no in- sulin are fit for service under certain conditions, especial- ly officers and persons of higher rank. The use officers, sergeants, medical officers and administrative officers who need insulin, in some special cases even troop officers as reserve troops is to be recommended, if possible in their native village, so that an appropriate diet will be guarant- eed. Untrained diabetics of the rank and file who need in- sulin are unfit for service, especially if they have had no military training and should not be drafted* Seriously wounded diabetics who need insulin cause great medical difficulties. As to the ouestion of disability due to active war ser- vice for diabetics still other causes of manifestation are to be considered besides an inherited disposition for a special disease. Diabetes may be caused b'r aggravated: li by different kinds of infections, alsi suppurat- ing wounds in individual cases aftei4 hepatitis epide- mics, protracted malarial fever and typhus, 2| by severe infectious pancreatitis and traumatic pancreatitis , 3. by wounds in the head caused by bullets, symptoms often appeared after an interval of delay, 4. by concussion of the brain (but only exceptionally} by a coma occurring during the time of service if the aggravation factor could not be compensated by hospital treatment, 6, by physical and mental strain if it can be proved that It considei*Hblyr'©xceeclb the*average. This question is very difficult and reouires great responsibility on the part of the specialist. 240 7, the same may be said of hormonal changes by per- manent effects. 8. by medical treatment if it was inappropriate or not given in time. The next sentence in the German text is garbled (Editors Note,) Disability for active service cannot be caused by aver- age physical strain or heat in a southern climate or frost- bite if no serious Infection occurs. he- lit us,* Erof^ssor^NONNENBRUCH Even before insulin was discovered KOHLISCH, CARL v, NORDEN, and FALTA demonstrated the favorable effect of a diet rich in carbohydrate and lacking protein and fat on the diabetic patient. It is the same with a diabetic treated with insulin. The normal diet of to-day has proved very favorable in this respect. By the additional food tations for diabetics approved by the chamber of ohysicians of the Reich, the fat and protein rations have been doubled. With this additional ration the diabetic oatient gets 1 gram of fat and 1 gram protein per kilogram of his weight and has to supply the deficiency of calories with carbohydrates, so that even with this additional food he depends upon an ample supply of carbohydrates. Owing to the nresent scar- city of insulin it is an important question whether the cutting of additional food rations and the making up of cal- ories by carbohydrates instead of protein and fat leads to an increased use of insulin. If so, we would better dispense with the additional food in order to save valuable insulin. According to our experience the food of a normal consumer with its low content of protein at present has served very well and led to no increase of the use of insulin. There- fore it is to be recommended that the diabetic be granted the food of a normal consumer. Diabetes itself does not exclude a fitness for active service. The fitness for ser- vice depends on every individual case on the intelligence and strength of mind of the diabetic. In a case of my own a seriously sick diabetic (a youth) grew into a well devel- oped young man and succeeded in oassing the final school certificate examination by adeouate treatment, he applied afterwards for service in the air force, concealing his dia- betes, and did his duty satisfactorily for several years ih a heavy anti-aircraft battalion. Some months ago when he was proposed for the rank of a reserve officer the diabetes was discovered during another medical examination and he was declared unfit for service. The young man was in excellent spirits during the years of his service, because hw was con- vinced that he was now at last fully appreciated. As a sol- dier he ate the normal food of the field kitchen and in addition to it took 80 units of depot insulin and additional injections of old insulin whenever he felt that he needed them. The discharge from service depressed him deeply. 241 &l£SU££l£I)-2£_ll2fi-2£££U££C£.££££££&ilie-dla£££££ GRAFE: Because of the war it was necessary to increase the ordinary pre-war supply with carbohydrates (about 100 - 150 grams). Besides that NONNENBRUCH and his collaborator FEUCHTINGER, tried increasing the supply of carbohydrates to about 350 grams as granted to a normal consumer but if possible with the same amount of insulin. The of a diet rich in carbohydrates oi4 free choice of any food is not new nor did Dr, NONNENBRUCH say that. In some cases it is without doubt possible to secure a higher tolerance of carbohydrates without increasing the supply of insulin pro- portionally, We have in our hospital all the time about 30 - 4-0 diabetics so that we are able to study all these questions of diet with a great many people and on a large scale. The examinations in civilian as well as in military hospitals showed that the cases described by NONNENBRUCH and FEUCHTINGER are exceptions and not the rule. Moreover it would be very interesting to know what happened afterwards to these patients, 4-3 cases of not too serious and serious diabetics who needed insulin showed that an increase of the supply of carbohydrates of 24% meant an increase of insulin of 28% an increase of carbohydrates of 30-70% on an average (460) an increase of insulin of 30%, an average increase of 86% of carbohydrates an increase of insulin of about 4-6% and an increase of carbohydrates of 14-0? an increase of insulin of about 70%, In all these cases the supply of carbohydrates has been increased to at most 3f)0-3$0 grams, in most cases only to 250 - 300 grams. The result of this large number of examinations, which is verified by numerous observations of the civilian depart- ment of the hospital proves that an increase of the supply of carbohydrates is of course possible but that at the same time the Quantity of insulin has to be increased though the amount will always vary and be insignificant. In one case the supply of carbohydrates was increased temporarily from 300 grams to 600 grams with the catastrophic consequence that extraordinarily high excretions of sugar occurred with an immediate decrease from 400 grams to 80 grams sugar per day. The excretions of sugar were so strong that insulin had to be injected, and so that even 101 units of insulin were reouired to make the sugar dianpear from the urine. It took five weeks before the severe injury to the carbohydrate metabolism had been removed and the former state had been obtained. Such a case shows how dangerous it may be to increase the supply of carbohydrates extensively. The continual clinical examinations have the advantage of being very exact. More important, however, is the ruestio:.: of how the situation develops when the patient is at home. Continual investigations of the treatment of diabetics give the best information about this subject. Prof. 0BERDISSE and his collaborators (FLECKENSTEIN, NAGEL and BEUEL) traced the fate of 190 diabetics who underwent treatment at the hospital during the last five years. This showed a distinct improve- ment of the condition of nearly all diabetics during the first few years of the war with ordinary food and the usual additional supply of carbohydrates of 120 - 140 grams on an 242 average. Their condition was even better than in peace time. This improvementrchanged to an aggravation as a rule since we have used larger quantities of carbohydrates (up to 250 grams) in the outpatient department. In all cases a compensation of the carbohydrate metabolism was tried, t i ... though it was not possible to do this with the same exactitude as in peace time. Thus we had to put up with an increase of blood sugar up to 0.17? and excretions of sugar up to 15 grams per day. We observed that the demand for insulin increased on the whole by about ten units per 100 grams of carbohydrate. Even in this case the result is the same, an increase of the supply of insulin, though a comparatively smaller one than the increase of carbohydrates* # In my opinion we shall have to make a compromise by granting the diabetic patients who need insulin, who at present are one half of them, a medium quantity of carbohy- drates from 200 - 250 .grams. To discontinue the granting of additional food to diabetics is not possible, SCHENCK: There are two tendencies regarding the judge- ment of the granting of additional food to diabetics, a) increase and steady recourse to the maximum rations of additional food, b) discontinuance of the granting of additional food with the aim to release food for other purposes. The latter tendency is of vital importance at present to diabetics and to patients with gastric complaints. The statements on which the demands for discontinuation are based are neither well founded nor true, A discontinuation of the supply of additional food for diabetics is out of the question and not intended. In the first place because the psychological effect would be very unfavorable. In the second place, it would require a com- plete change of treatment of mahy thousands of diabetic > patients which would be impossible at present. In the third place because the observations on which the demands for dis- continuation of the granting of additional food are based have not yet been reexamined sufficiently, SCHULTEN: The increased demand for insulin during the war is not only caused by an increase of the consumption of carbohydrates by diabetics but also by prescribing insulin Tor nondiabetic patients, above all those suffering from hepatitis. This latter should be stopped altogether, because iV ia useless, LANGE: In the IV, Military District a special unit has been formed for diabetic personnel.According to the status Of 15 April 1944> 1229 diabetic patients had not been drafted, U9 had been discharged as unfit for service. After setting aside indispensable diabetics 360 are available for active duty. They are employed for guarding prisoners, A physician experienced in the treatment of diabetes was assigned to that unit. Experience with these measures is to be described later 243 Directives concerning the treatment and evaluation 2X_Mab5txg_lsil.it usA The aim of the treatment of diabetes is a regulation of carbohydrate metabolism with a tolerance of carbohydrates as high as possible and a supply of insulin as small as possible, Whereever it is possible an approach to our present food ration which contains little protein and fat is to be obtainec An individual treatment and control of the food intake is necessary in every single case. Cases of mere renal diabetes are fit for service. Dia- betics with a tolerance of more than 500 grams of carbo- hydrates without insulin are also fit for service. Those wit: & limited tolerance, as also those in need of insulin, have to stay at their place and are fit for service in the reserve and have to maintain themselves. This especially applies to soldiers on active duty, higher ranks,and officers. Diabetics without military training who need insulin are not to be drafted. Diabetes is in most cases inherited. Diabetes acouired only after pancreatitis or following injuries in the bead is a very rare case. Even with an inherited disposition for that disease are causes producing the symptoms and aggravating them which accelerate the outbreak and lead to a more serious prognosis. Such -.are, besides serious injurie to the stomach and the brain serious, especially chronic, infections, suppurations or previous states of coma. In all cases the question of the influence of war has to be ans- wered in the affirmative , Physical strain cannot be made responsible for the onset or an aggravation of diabetes. Ex- ceptions are only possible if it can be proved that the pat- ients have undergone excessive and abnormal physical and psychic strain. Each case must be judged on its own merits and it is sometimes very difficult to arrive at a definitive deci sion. 5. Concerning the treatment and evaluation of rheumatism Ag££flYat io&_and_psychi ioriA Qberfeldarzt ( Lt. Col. Prof. BECKMANN In the winter 194.1/4-2 polyarthritis had a high incidence in two armored tank regiments which were living in overcrowd conditions, as a senuela of an angina epidemic, of the soldiers were afflicted with the disease for about a yeat and their number did not decrease until older men were drafted into these regiments. This observation emphasizes the idea that it is chiefly the tonsils which ar° a focus of polyarthritis among younger men. The therapy of acute poly- arthritis has to be started with a big dose of salicylate (&-1Q grams) or pyramidon (2-3 grams). They have to be administered until the acute inflammations have subsided for the most part. Then the dose should be reduced slowly by stages. Intensive therapy with large doses for only 2-3 days has proved a failure. As soon as the tendency to a 2U fixation of single joints manifests itself passive exer- cises have to be started. In milder cases the patient may be urged to exercise his limbs himself, even during the initial stage. Very early hydrotherapy (thermal baths) may be applied in individualized plans as soon as the temperature has become normal, even if the blood sedimentation rate is still high. Usually the sedimentation rate returns to normal again relatively quickly with the baths. The most important thing is the exercise of the limbs , Greater mobility is the chief the exercises are the way and the hydrothera- peutic measures are the means to make the exercises easier. In order to strengthen the reaction of the body all other physical measures are to be employed (mud baths, underwater massage, slowly increasing individualized gymnastics, later on walks under supervision and sport.) Cases of acute and chronic polyarthritis must not stay too long in the general internal medicine wards. If no appreciable progress has been attained six to weeks, they are to be transferred to a special hospital for patients with rheumatism. On the other hand, not every heal- ed polyarthritis has*to be treated by baths. This is only to be considered if disturbances of function still exist. In this way the long duration of the disease might be shortened considerably in many cases. A separate estab- lishment of general hospitals, soecial hospitals, for rheu- matic patients and hospitals for convalescents as proposed by TICHY is not required. Complete convalescence can be achieved in a special hospital for rheumatic patients. It is not necessary that the patients should have become free of all complaints. The further supervision has to be under- taken by an army surgeon who must be thoroughly informed in this field. By this plan it is possible to render the major- ity of the patients fit for service again in well appointed special hospitals. Chronic and constantly relapsing cases are to be discharged in due time as unfit. Vegetative dystonia is much more freouent with rheumatic patients than with other diseases (6$ as compared to 3,8$), Psychic fixation is freouent in the beginning in of persistent pain, but disappears with increasing improvement and increasing ability to move. It very seldom gro?/s worse. Simulation of polyarthritis was observed in on.ly one case. For the treatment of sciatica the same points of view obtain. Exact diagnosis and exclusion of all other organic changes are required, (arachnoiditis, meniscus prolapse, sacralization, static moments, etc.,) and these procedures are best carried out in a special hospital for rheumatic patients or on observation wards. Sciatica showing no im- provement within four weeks has to be transferred to a special hoopltali We shall succeed in rendering fit for act- ive service a great many sciatica patients within 6-8 weeks by special treatment which lays oarticular stress on systemat- ic muscular exercise. Chronic and relapsing cases are to be discharged as unfit. Among 89 serious stubborn cases definite deterioration was observed in only one case, while in two case: there was a suspicioh of deterioration and in 12 cases strong psychic factors played a role, 5U cases suffered from in- volvement of the nerve root (in the form of arachnoiditis) was observed and five from intervertebral disc prolapse. Strong psychic influences are much more frequent with sciatica pa- tients than with polyarthritis patients. To be successful it is essential that the special hospitals for rheumatic pati°nts have available a sufficient number of well trained personnel (women trained in gymnastic exercises and masseuses). The baths are to be given in the hospitals if possible. Of special importance is the super- vision and care of the patients by an army surgeon after their discharge from the hospital. 6X Concernl ng._the treatment_and_evaluati on_of_Rh^umatic fever and Neuritis, Aggr a vat i o n_and_ Psychic Fixation^. Stabsarzt (Captain M.C.),Profa_PANSE I think a psychiatric concept of rheumatic fever may contribute considerably to a solution of the complicated problems of the rheumatic diseases. Though modern invest:? ations of rheumatism have widened considerably the knowledge of etiology and pathology, the physician and the patients still cling to traditional and vaeue notions concerning rheumatic Often a diagnosis is established which has no objective basis. This causes vague misgivings to the patient and induces him to fear that he may be afflictc with the disease. The results are those frequent psychogei symptoms and fixations accompanying rheumatism concerning which I intend to speak principally% Acute articular rheumatism, rheumatic fever, implies a psychic burden by its organic conseouences e.g. with myo- carditis, inflammation of the serous membrane, or during relapses which cause psychogenic reactions. This is especi. ly true with the numerous cases of chronic and relapsing arthritis which may be differentiated from genuine rheumati fever and must be traced back to focal infection. The fre- quent uncertainty as to the etiology, the vague nature of the complaints, the resultant diagnostic uncertainties and the attempts to find the focus aggravate the feeling of bei: sick and draw the attention of the patient to the physical processes, by which a hypochondriacal psychogenic attitude may easily be caused which in time becomes fixed and can be removed only by effective suggestion therapy. The more localized the rheumatic symptoms are the mor freouently will the forms of strong psychogenic reaction- be transformed from a general hypochondriacal dejected att tude with the typical " facies psychogenica" to circumscri; relief attitudes, anomalies of attitude and contractures of the affected parts. The great numbers of localized infect:, arthritis of the spine and several larger joints are to be specially mentioned. The soldier at first is led to close self-observation by the steady dull pain and the increase pain with certain movements. Relieving, evading and prote ive postures are assumed which may become grotesoue, ster> typed and quite unconscious. The resultant state can be plained etiologically only by close cooperation of the in' ist« with the orthopedists and the psychiatrists with the neurologists. Even serious changes of posture and contract- ures which have considered to be organic for years, have been proved to be psychogenic and susceptible to removal. These psychic influences are by no means alv/ays hysteric- al, that is they are not so often malignant as is generally supposed. Chronic rheumatic diseases are often unconsciously caused by a steady fear of disease and an abnormal fixation of the attention on the processes of the body. They are seldom really hysterical or demonstrative and have therefore nothing to do with genuine deterioration or simulation. The latter is the case far more often with acute neuritis and neuralgia, with which patients often show a tendency to evasion. The more chronic these states are, e.?, with sciatica, neuralgia of the brachial plexus or freouent acute infectious polyneu- ritis, the more the psychogenic processes resemble those of rheumatic fever. The psychic reactions are due to autosuggestion and can be removed only by suggestion therapy. Every well planned and purposeful program of therapy carried out by a physician with healthy optimism is valuable in this respect, and can avoid the development of psychogenic influences. Aimless diagnostic and therapeutic attempts have the opposite effect. If, however, psychogenic influences have once appeared, only consistent suggestion therapy will be successful. The following procedure has proved especially successful even in the most serious cases. The treatment by suggestion begins by using a diagnostic apparatus with unobtrusive opti- mism and with a number of special examinations adapted to the complex of complaints. The "favorable" result is assured every time and the eventual certain cure is stressed. All the time the physician must systematically avoid permitting the patient to know whether he considers his condition as psychogenic or organic. The physician must not allow any doubt or other influences to be reflected in his manner no matter how well justified they may be. a powerful gal- vanic current is applied at short intervals together with verbal suggestion. This treatment represents an impressive experience, the effect of which practically never fails with a man who is well prepared by suggestion therapy. It is ad- visable to reserve the treatment itself to the neurological wards of special hospitals adequately equipped for the pur- pose and containing a large number of organic cases for the physician too has to be thoroughly familiar with this treat- ment and surroundings furthering the suggestion are indis- pensable. Directions for,.the ,treatment^of rheumatic fever and neuritis 1, Cases of polyarthritis or sciatica showing no parti- cular tendency to improve within four weeks have to be sent to a special hospital for rheumatic patients, 2, A thorough elimination of all foci of infection is absolutely necessary. Salicylate or pyradidon treatment in high doses is not to be carried through for a short time only, but until the acute symptoms have disappeared. Then the dose may be reduced slowly. Passive or active exercises are to be applied early. Hydrotherapy may be begun aftor the fever has subsided even if the sedimentation rate is still above the normal, 3, The special hospital for rheumatic patients must have at its disposal a rhinolaryngologist, an otologist and a department of dental surgery. Baths shall be furnished in the hospital if possible. The hospital for rheumatic patient-; should be fitted out with sufficient personnel (personnel for gymnastics, masseuses), 4., Psychogenic influence and disposition to aggravation (mostly in the form of comulsary and relief attitudes) are more rare with polyarthritis than with sciatica and kinds of chronic neuritis. Psychic guidance by a physician is essential. Serious and persistent cases shall be to a neurological ward established for that purpose as soon as possible, for a proper treatment by suggestion. 2* Corjcerr}in£_the_evalu,ation_of_non-or£^nic_heart_disoasns (vegetative, postinfective and other types). Oberstabsarzt (Major M.C.) Prof. BANSI Non-organic heart diseases are extraordinarily frequent* Their evaluation is very difficult especially for younger physicians who adhere too much to the minor findings of the technique of diagnosis in their judgement. The evaluation of this big grouo of soldiers with strong subjective heart complaints was discussed even during World War I,(WENCKEBACH), If organic heart complaints are to be set aside after a thorough general examination and detailed clinical study, a clear opinion is to be given* Classification 1* Hypertonia without anatomical dilatation of the heart and involvement of the kidneys, 2, Disturbances of the circulatory control center, 3* Vasoneuroses, including angina pectoris spuria nervosa. In addition are to be mentioned: 4., Postinfectious instability of the circulation, 5. Heart complaints after injuries to the lungs and 6, Neurovegetative disturbances of the central regula- tory mechanism chiefly on a hormonal vegetative basis. Hypertonia: Variable systolic pressure without anatom- ical changes of the heart muscle which can be observed very often with young people is unimportant (Class A-defect). The same applies to abnormally high and slowly decreasing blood pressure reaction to exercise. Blood pressure which is con- stantly above 14.5 without involvement of the kidneys and \Bart hypertrophy are to be considered as class B-defects Q.iv'rdt«g' ter th© Regulations*of last yetir, Ope must search for infectious foci as a cause of hypertension. Disturbances of the conduction mechanism: Uncomplic- ated ventricular extrasystole which does not increase with work is not important (class A-defect). If the extrasystole increases with work or if it is of multifarious origin, myocarditis must be supposed. The latter is usually a sequel of chronic or acute infection. Aft«r three months another examination and evaluation of the symptom which was considered as a Class L-defect previously must be carried out. Supra- ventricular extra systoles are to be considered as a Class 13- defect just as is sinus rhythm which appears in the state of rest, if no other symptom' of a heart muscle defect can bo ascertained, Essential paroxysmal tachycardia prevents the fitness for service during the attack. According to the freouency of those attacks a Class B-or L-defect must be supposed if other organic findings are absent. The same applies to the electrocardiogram (EKG) finding of the so-called Kent's bundle, in which case •ccasionally abnormal conduction mechanism may set in with exercise. The most frenuent of all obscure non-organic heart troubles are the circulatory neuroses of patients suffer- ing from neurocirculatory asthenia. These patients are in most cases very unstable and generally inefficient indivi- duals with numerous subiective complaints and symptoms con- nected with the vascular nervous system. They are not easy to train and are, especially if symptoms of the sympathicus are oredominant, usually very uneconomical workers (ergo- tropic type of Hess, Graves' disease). They reach the limit of cardiac efficiency with a low level of consumption even if trained to use the vagus as a spare part (protect- ive measure) for better utilization of the oxygen in the blood and an adequate increase of the volume of the single heart beat (Histctropic type of Hess), In spite of this heari failure has never as it is with organic heart diseases, such as old vitium cordis and unrecognized endocarditis. Those patients usually do not complain much and occasionally decompensate acutely if subjected to special burdens. The majority of these vascular neurotic persons are absolutely fit for service and can often be trained together with healthy soldiers (class A-defect). Only very serious chronic tachycardia (the pulse has to be counted also at night) with a considerable general decrease of efficiency is to be judged as Class L-defect, on the basis of clinical judgement. They are to be evaluated in an ob- servation hospital or a corresponding medical institution ox the field army, to prevent their shirking service by a pro- longed stay in a hospital, Sven individuals with heart com- plaints caused by angina without anatomic causes, which occur very often among juveniles are fully fit for service. One must be careful not to overvalue insignificant electrocardio- graphic deviations such as slight lowering of the ST deflect- ion in leads II and III (loss than 1 millimeter ), bow shaped transition of the S deflection to the ST deflection* negative T3 with high P2 if T3 rises with deep inspiration. Generally the electrocardiogram is overvalued and important diagnoses and corresponding evaluations should be deduced only from the EKG showing the physiological response to work. 249 Many deviations of the FKG may become retrogressive and need not be due to an irreparable lesion of the tissue,-' Postinf °f the circulation must be watched closely, especial1y with the younger soldiers, in order to prevent permanent damage. 1 hey'appear after the usual infections, such as hepatitis, diarrhea, Volhynia- fever, tularaemia and above all after typhus. Hypertonia after typhus must be mentioned. It probably has a central origin, as also the not infrenuent increase of blood pressure after diphtheria. It is these young soldiers who care- ful medical treatment after infectious diseases, to prevent these young men who are still at the stage of adolescence from overwork, Postinfectious hypertonia of young people with a disposition to collapses must be mentioned. In the electro- cardiogram the border-line pictures which I mentioned are to be found. The prolongation of the PQ interval is a fre- quent sign of a toxic heart involvement. If a decreasing PQ prolongation appears in th° FKG on exercise with trained individuals, it is not %»• be considered as pathological. Young soldiers with uostinfectious functional irregularities of the circulation should be released from hard work for three months. The findings should be checked during a period of three months. Systolic murmurs are often misinterpreted. One ought to ascertain whether they disappear with deep inspiration or change their sound when the patient is recumbent, which will prove their accidental origin. Even the roentgenolo- gical measurements of the heart, must be regarded with dis - crimination. Not every large heart is diseased. The athletic heart caused by excessive sport activities in early youth is a symptom (,pay attention to the kind of sport). Heart complaints with persons with injured lungs are intelligible even if no abnormalities of the pleura appear in the X-ray, or abnormalities of the autonomic nerves can be demonstrated. If functional disturbances of a greater extent exist they are to be considered as a class L-defect, It is important to calm the men about the "ball in the chest" which is often very harmless* Let me mention in conclusion the simple neurovegetative disturbances of the regulation of circulation: 1, The border-line cases of hyperthyroidism compared with the real picture of thyreotoxicosis and Graves1 disease^(situational hyperthyroidism considered as B 41). 2, The disposition to spontaneous hypoglycemia without direct primary hyperfunction of the pancreas v/hich may appear in addition ta bulemia during periods of weakness of a marked vasomotor character (BI52) 3, Tetany syndrome vfithout evidence of hyperfunction of the parathyroid glands. Often somewhat infantile young soldiers are concerned (Bl^) 250 A. Syncopal vasomotor attacks manifesting themselves by orthostatic collapses or cardiovascular syncope. The attacks are as a rule very rare and appear only after overstrain. According to the frequency of attacks they are to be considered as B or L defects. If organic findings can be excluded after a thorough general and special cardiac examination, the physician has t» realize the fact that every one has to do his duty by the community to his utmost. It is the large group of the less efficient that are oft°n protected with unwarrantable lenience while war selects with the utmost cruelty the best of our meople* st urbane esA Stabsarzt (Captaip M.Q r } Prof . RUEHL Fxaralnations of the circulation can be only a link in the general medical evaluation and presupposes a know- ledge of the history and clinical, roentgenological and FIG findings. Their chief problem is - establishing the general capacity of the circulation as well as the functional differ- ential diagnosis that is the differentiation of he disturb- ances caused by the heart from those caused by t' e vessels and the discovery of latent defects. The latter i s important especially for deciding the question whether they are organic or functional. The kind and the amount of tke strain imposed have to correspond to the desired purpose. Customary work loads, such as physical work (in relation to the weight of the body) are as a rule to be preferred. An exact adjustment of the work load is imoossible on principle. Any transitions are possible from the simple sitting up in bed to sprinting* Certain regulations may be given only for certain frequently returning purposes (e.g, enlistment and outpatient examination The work load imposed most not b'- too small (30 to AO knee-1 bends, or running up and down a staircase of 10 Meters length twice a minute). It is important to consider the patient’s attitude to- wards the strain of daily life (history) also the observations during gymnastic or military exercise. Thus an Impression of the processes is obtained which will complete the moment- ary impression, derived from examination of the circulation* The processes of circulation and respiration which occur with the simple strain of physical work are so complicated, that their evaluation requires the greatest caution. Above all the extraordinary influence of the vegetative nervous system is to be considered and this is particularly strong during the usual short test. rxtcrnal influences (lack of sleep, nicotine, fever etc.,) and psychic factors play an important part. The facto£ of training may have a decisive effect. Therefore we are justified in speaking rather of an examination of the regulation of the circulatory nerves than of an examination of the function of the heart. We point out the importance of repeated attempts to differentiate the nervous influences , It is correct to call cyanosis and dyspnoea after work an indirect sign of a disturbed general circulation (aside from nervous tachypnoea) when pulmonary factors e.g. emphysema, are excluded. Also, observation of the general attitude especial1y of the expression of the face are of importance. Ascertaining how long the patient can hold his breath after deep inspiration has the dis- advantage that it depends on the will-power of the sub- ject and can therefore be used for military purposes only under certain conditions. Decreasing or constant blood pressure with increasing frequent pulse at the same time is to be considered as poor or uneconomic action of the heart. Steady deep in- spiration and frequent pulse after work are signs of an absence of work economy. Nervous factors have such an important influence on the height of blood pressure, that a calculation of the quotients from percentage changes of amplitude and fre- quency as a basis for Judgement is to be denied, A venous stagnation (with insufficiency of the left heart it can be recognized by decrease of vital capacity after work) can be ascertained only after a genuine failure of the heart while an evaluation of the values of the vital capacity has to take into consideration the psychogenic factors , It seems doubtful whether the variations shown in the work kymograms (enlargement of the silhouette of the heart with a reduction of the deflections ahd a change from type I to type II according to STUMPF) may be uti- lized for evaluating heart conditions concerning whose nature one is not certain apart from the technical difficult- ies, These doubts are due to the nervous influences on the muscle contractions of the heart and to the uncertain- ty about the decision as to what is to be considered as the normal state. The usual strain of work, with a measurement of' the blood pressure and observation of the inspiration may be combined profitably with the making of an gram during work. It is sufficient to ascertain the values shown by the EKG, three or five minutes after work, accord- ing to the directions on EKGs, The FKG during work is without doubt one of the most important practical function tests. It is,however, able to demonstrate only latent defects (e.g. coronary insufficiency or myocardia) but it never shows anything efficiency of the heart because its contour is only the manifestation of a process of excitement. A critical Judgement of the EKG findings is very important because of usual overvaluation. Changes which are caused by frequency must not he considered as symptoms of disease. Prolongations of P° after work, enlargement of ORS in the form of intraventricular disturb- ances of the conduction mechanism (the utilization method of 252 Schellong is of no use for practical purposes) freOuent appearance of extrasystoles especially thos"> with different origin of the stimulus and certain ST downward deflections than 1 millimeter with normal gauging) are to be re- garded as pathological. Most is the ST downward deflection in leads I and II, as well as in leads II and III with a right deflection (Rechtstyp) at the same time not only in lead III. Marked T flattenings or iso-electric T are to be considered as pathological only in leads I ahd II* The seriousness of the FXG changes can be used only under certain conditions as a basis for judging the degree of anatomic lesion. It is of great general importance that changes based on electrocardiographic findings alone never justify the diagnosis of coronary insufficiency or myocar- dia, As a matter of orinciple th diagnosis shall depend altogether on the general clinical decisions and shall not be established by the physician who judges th'* findings of the EKG. The influence of nervous factors is to be recognized also for the EKG under work load which can proved very distinctly in the EKG in cases of so-called orthostatic strain, I think that the ST downward deflection occurring with it are no manifestation of disturbed blood circulation in the coronary arteries nor are they due to haemodynamic causes. They depend also only partly on frennency* Their disappearance the administration of justi- fies the supposition that they are only nervous vegetative changes in the contour of the EKG, The EKG under anoxia has so far been only of theoretical importance as a test of functions, A practical wider application is made difficult by uncertainty about the limits of the normal state and by doubts about the harmlessness of the method if practised by unexperienced persons. Besides the t~sts of the functions of the whole cir- culation and of the heart, another eeually valuable field of circulatory examination is to be mentioned which is un- fortunately often neglected, namely the testing of the function of the peripheral circulation. Those methods which make it possible to test the peripheral circulation independent of the effieiency of the heart (Schellong test) with recording the systolic-diastolic blood pressure and pulse freouency immediately , 2 and five minutes after simple (active) standing up is recommended for practice. Greater lowering of the diastolic as well as the systolic blood pressure (more than 20 millimeters) indicates a pathological disturbance of the regulation of the peripheral vessels. It must, however, be pointed out that such patho- logical hypodynamic or hypotonic disturbances of the regu- lation as well as orthostatic collapses ar° to be observed comparatively seldom, because the strain is too weak. To increase the strain on the perioheral circulation, a special method has been developed which consists in having the patient stand up ten minutes after an injection of 1 milligram of histamine combining thus the mere orthostatic mechanical strain with a dilation of the capillaries of the patients (measuring blood nr°ssure and the frequency of the pulse up to ten minutes after standing up). The criterion far judgement is the following collapse itself. This method has proved useful for estimating the predisposition for collapse. Pathological collapse reactions were found most often with injuries due to infection from pneumonia during convalescence from focal toxicosis as well as with a hypo- tonic complex of symptoms, but not with psychogenic collapses* The method, however, still requires a'more widespread ex- perience and cannot yet be used in the army. The preceding report had to be confined to the simple tests of the function of the circulation as practicable in army hospitals. Regulations are practically impossible. In every single case the general medical judgment is de- cisive * DVS£U?sipn of„tfro reports_.CQ.ncernin£._gyaluatjpn_«f_ £ii.Qic_hQa?t di sedges. Vegetative dis^urh- aa5fij§_££„the_re£ulatioa_of_circula,tip£__Xj20St -ijj- fectfrve and other types) and Tests of Circulatory li^ctioiU KOHBROCK: The eases of latent typhus without a rash which not detected in the army and without direct clin- ical symptoms indicating a simple infection are now more frequent. They concern patients who are to the hos- pitals with subjective heart complaints, r/e find with them objectively, not only insufficiency of the peripheral circulation but above all insufficiency of the heart muscle associated with the complaints of a coronary insufficiency. Roentgenology and electrocardiography give us no information either at rest or after work. Often a specific sounding second tome of the aorta -indicates a progressing aortitis while in some this second tone of the aorta is almost a sign that the patient has had typhus. The WEIL-FELIX reaction will then confirm the supposition. Altogether the number of patients with latent tyhpus to be greater than is often supposed. Some cases of peripheral paralysis of unknown etiology at first or such cases as showed persistent- ly recurring low temperature who had had influenaa or even angina in the army were found to have a positive WEIL-FELIX reaction of at least 1:200, GUTZEIT: For the diagnosis of non-organic disorders of the circulation, the record and the general impression made by patients are much more important than any single symptom. The younger and inexperienced medical staff officers need constant instruction and training in this respect. It is of psychological importance to not give hhe patientsany information about the diagnosis of symptoms (EKG, pressure) and in case of unimportant symptoms or absence of objective findings to declare that the person 14l>s in-sound health, BOHNENKAMP* All doctors agree th’.t no adequate diagnos- is can be based on single EKG findings or roentgenological finding alone in case of non-organic disorders of the heart and circulation. But the group of inefficient soldiers having pronounced disorders of the circulation whether iso- lated or general disorders of the central machanisra (change of stumpf type I to type II etc,,) is to be regarded with suspicion and should be followed up to be evaluated by the use of every available clinical method and exercise test including EKG, roentgenology and especially roentgen- kymography and the determination of the time for tension and relaxation according to Blumherger, Impressive experiences are reported. A physician in good physical condition and an excellent sportsman who had been observed for a long time developed a block in conduction after short service in the war though his EKG showed an alteration which had been considered as insignificant etc, BOCK; There is no standard simple method of testing iin£iion_of_the_£i 1oji.il, In the general range of a complete clinical picture, the time of circulation is to be ascertained, especially the difference between the period of action of decholin minus the period of action of ether. This enables us to measure the efficiency of the left ventricle. The standard value is not above seconds. An increase of the decholin-ether difference in- dicates a poor propelling efficiency of the left ventricle (further particulars about ether decholin fluorescence process of BOCK and FINK are given in the Congress report of the Deutsche Gesellschaft fuer Innere Medizin, Wiesbaden, 1936), The following statements apply to all stand-up tests as functional tests. Anybody may have an orthostatic collapse. It depends on the manner of standing. Deeper inspiration and slight movements of the leg muscles will further the venous reflex considerably and delay or avoid collapses considerably. The conditions for such tests must follow certain strict rules, SCHULTEN: A differentiatioh of local heart disorders and vegetative disorders of the regulation of the circulation is of practical importance. Many physicians even specialists, recognize only the former which arr in reality rather scarce* Only the heart disorders e.g. after diphtheria are to be regarded as more serious. A great number of patients with disorders of the regulations are fit for service and are to be judged, strictly. VOLHARD: Do you m»t think genf 1 ernen that it would bene- fit these vegetatively unstable persons mor° than a hospital treatment if they could live in the same surround- ings as these here in Hohenlyehen, If they could have such an excellent treatment with slowly increasing strain by gymnastics and sports under such an experienced leader, I do not doubt that we should succeed in improving their con- stitution and in making their heart and circulation more ef fici ent # GUTZEIT: I should not treat patients with functional non-organic heart complaints, except chronic tachycardia and postinfective symptoms of weariness, in hospitals, but discharge them as fit for service. Experience teaches us that in spit'' of my efforts for y°ars to carry our exercise and work therapy it is not carried out in most hospitals and that the patients in convalescent homes get better only if strict medical control is guaranteed, but in the most cases the latter is lacking. ANTHONY: With men In the Air Firce too we find, dis- turbances of thra regulation of the circulation after great strain. A treatment in convalescent homes or hospitals carried out sufficiently early which lays a special stress on athletics and snort proved to be very effective for the purpose of making th~ ">ati°nts fit for active service within a short time, DELIUS: As to non-organic heart and circulatory diseases, it is recommended to differentiate between local- ized heart complaints or disorders and disorders of the regulatory mechanism. The latter can be classified etio- logically as infectious, toxicologic and constitutional cases and those due to old age, In a pathogenic respect, no heart disease but only functional disorders of the vegetative system are to be This has been proved by experiments. In a symptomat o logi c respect, we distinguish between hypertonic, hypotonic and normotonic disturbances of the control mechanism. The hypertonic ones are similar to the complex of symptoms thyreotoxi- cosis, Hypotonic disturbances of the control mechanism , perhaps hyposympathicotonia, are frequent with old men in the form of extreme exhaustion. They are vagatonies causing general inefficiency, Normotonlc or poikilotonic fiisturbances of the control mechanism are di?f:cult to deter ine by bllod pressure and records but : n most bases they are easy to ascertain by stand-up by keening a record of the electrocardiograph and the reaction of the blood pressure. The orthostatic changes in the shape of the ENG are certainly due to the influence of the heart nerves. In pathogenic respect :t is perhaps a case of vasomotor coronary insufficiency. We vn*w they can be influenced pharmacologically, / Por purposes of evaluation it is to be recommended that patients with postinfective disturbances of the re- gulation and some other hypotonic disturbances of the re- gulation appearing as extreme exhaustion, be treated tem- porarily with consideration and to exercise them in a cautious way. Some constitutional disturbances •f the regulation mostly hypertonic, are to be considered as chronic with typical “failures”. They are to be classified as fit under certain conditions. The other disturbances of the regulation can be -judged as class A-defect, BANSI : Eor particularly serious constant tachycardia with considerable restriction of activity an evaluation ,3 an L 49 deficiency should be possible in an observation ward or a correeponding hospital department of th« army, Postinfectiore circulatory instability : s to be judged as L 4.9 for 8 weeks and even up to 3 months, RUEHL; I am pleased to that we all that the ENG deflections in the stand-up test are of vegetative nervous origin and unimportant. The effect of the #2 deficiensy test'makes us deny a coronary insufficiency. The Gynergen test cannot be carried out in a military en- vironment. The histamine-stand-up test cannot cause heart damage as the dose of histamine (l milligram) is too small. The Jarisch-Hezold effect is not at all likely to cause heart damage. 256 The determination of the time for circulation yields useful results only in case of pronounced insufficiency* The tests of the function of the circulation have their proper use in border-line cases. General Directions about; a.* Freouent nqn-crganic heart diseases end vege- tative disturbances of the ¥unctional disturbances of the circulation without organic find- ings are extremely freouent, I suggest the following discrimination for practical purposes: a) Essential hjrpertonia without involvement of the heart and without kidney findings are to be classified according to deficiency B 49. The unstable increase of Mood pressure of juveniles due to the vegetative system of juveniles hw to be classified"1 aa-'.-a' class A 49 defi- ciency, b) Ventricular cxtrasystolo is harmless if it disappears after exertion (A 49), Multi ocular, ventricular a£d supraventricular extrasystole may be a sign of myocarditis (focal toxicosis) and should bo given a preliminary classification as L 49 with secondary examination after 3 months. Paroxysmal tachycardia is to be regarded as a class B or L defect according to the frequency of attacks even without organic heart findings* c) of vasoneurosis, also those with anginoid cimplaints, are to be considered as class A-defects, Only the rare casps with chronic tachycardia (above 120 beats) persisting after long with a considerable limitation 4f efficiency can judged as a class L defect ijj an observation Ward or correspondin’' depart- ment of th* army* Soldiers with tachycardia caused by increased sympathicotonia afe less efficient and hard to train, but do not suffer from heart disease. They are fit for service (A A9) d) fvftry infectious disease may leave behind a circulatory instability disappears after weeks -©* aonths and needs careful control, A reexamination after three months at the latest should be routine, Syatftlie noises which are loudest above the pulmonary area and become louder with deep in- spiration or in recumbent position and which dis- appear nearly or completely with deep exhalation or on standing up are accidental and unimport- ant, A moderate dilatation of the heart in the X-ray without clinical findings is frequent and is not caused by an enlargement of the heart (athletic heart of the sportsman)* e) Heart complaints after Injuri-s to the lungs, also without organ.i zation of the pleuropericard- itis, are caused by irritation of the vagus or symphaticus (disposition for extrasystole and fainting fits), and should be classified accord- ing to L-49 but only if a considerable functional disorder exists If vegetatively unstable patients are haz'd to train they are to be transferred to hospitals for patients with slight disorders and with work therapy, b* Tests_pf_the_Functipn_pf_th^_Ci Test of the function of the circulation can only be a link in the general medical judgement and must be based on the record of the disease and on clinical roentgeno- gical and FKG findings. Their tasks are the following: To determine the limits of the capacity of the circulation to bear strain and to discover latent defects b'* functional differential diag- nosis, A constant test load is impossible. Special norms can be fixed only for particular frenuently recurring purposes in which case too slight a strain upon muscular exertion should not be chosen. The attitude during the strain of daily work and soort are also to bo consider- ed , The circulation and respiratory processes depend so much on the vegetative nervous system (psychic and external influences, training factor) that we can only with extreme caution infer a lack of efficiency of the organs from the result of a test of the function. The respiration as an indirect symotom of a disturbed efficiency of the general circulation, as well as cyanosis and dyspnoea are useful symntoms besides observation of the general atti- tude (expression of the face of the exhausted patient). The measurement of the length of time a patient is able to hold his breath after deep inspiration can be used only under certain • •n- di ti ons. If the amplitude of the blood pressure becomes smaller fcr remains the same, uneconomical heart efficiency may be supposed, Continued rapid breathing and pulse rate is a symptom of poor work economy. Calculation of ruotients out of percentual changes of amplitude and frenuency as a basis for evaluation is rejected. The usual strain by work may be combined pro- fitably with the making of an FT'G during work. Though the latter gives no indication of the efficiency of the heart, because its shape is 258 only an expression of a process of stimulation it is important that electrocardiographic diag- nosis should be based on a general examination by a specialist and not be made only by the doctor who reads the FKG, For testing the regulation of the peripheral circulation an orthostatic strain such as the stand-up test is to be recommended. A consider- able lowering especially of the diastolic as well as the systolic blood pressure (more than 20 millimeters), indicates a pathological disturb- ance of the peripheral regulation.