Beprint from the St. Louis Courier of Medicine, April, 1883. THE CONSTITUENTS OF A SUITABLE CLIMATE FOR THE VARIOUS FORMS OF PULMONARY. CONSUMPTION. By J. Hilgard Tyndale, M. D., New York. THAT there is no rule without exception goes without saying; that exceptions do not invalidate a rule is quite equally true. With this latter maxim in view, we will endeavor to find what constituents of climate com- bined are suitable to the majority of patients suffering from pulmonary consumption. Nothing could be a greater fallacy than to try to find a specific cure-all, either in the home or climatic treatment of consumption. Nor can we, in the present light of our knowledge of phthisical pathology, look upon that disease as a unit, but rather as a combination of the two main elements of disease, namely inflammation and infection. This combination and destructive co-oper- ation of a localized inflammation and general infection 294 Original Articles. [April, 1883. presents itself either as a chronic inflammation or an acute one, and as a chronic or acute infection. The various de- grees of intensity and of quantitative destruction result from the variety of combinations possible where four con- stituents are given. A chronic inflammation may exist alone (fibroid phthi- sis, cirrhosis); so may a chronic infection (chronic local- ized tubercle, cheesy centers); both may exist together,, this being the most common form of cavities and infiltra- tions; an acute infection may occur alone (acute tu- berculosis) ; an acute inflammation likewise, which, aside from the acute inflammation of lung tissue, occurs as sub- acute processes in the vulnerable (strumous) as “catarrh of the apex; ” while, during the progress of a phthisis, an acute attack appears in the shape of an exacerbation. Lastly, in the progress of a chronic phthisis, made up of the processes of inflammation and infection, one of these pro- cesses will assume an intensity out of proportion to the or- dinary course, when the result is death from suppurative peri-bronchitis or edema of the lungs in one case, or from acute tubercular invasion in the other. For the purposes of climate—therapy—it is convenient: 1. To divide the chronic pathological processes in the lungs into a few general divisions, representing three stages of development for two classes of persons: the robust, and the irritable or vulnerable, either of whom may have been drawn below their physiological line by being exposed. 2. To find for these various forms of phthisis the best conditions of climate for curing or mitigating the disease — to secure more or less permanent arrest. This much is prefaced, in order that what follows may be readily understood. The pathological conditions in consumption are readily fitted into these several frames : 1. Superficial cases—so-called because the inflamma- tory condition of the respiratory tubes is still superficial, though chronic, with little or no involvement of the sub- Tyndale.] Climate for Pulmonary Consumption. 295 mucous connective tissue, where there is no septicemia, hut a lowered general condition, this latter constituting the cause of the superficial process, which without it would not exist. 2. Cavities and infiltrations of the regulation sort, slowly hut persistently progressive chronic inflammation (ulceration), with more or less septicemia (infection). 3. The same, in the condition of superadded acute or subacute exacerbations, occurring intermittently or remit- tently. Long intermissions often give rise to that mis- taken idea of “ self-limitation.” 4. Assuming these forms to occur in the average indi- vidual, whether previously particularly robust or not, we find it necessary to assume the same conditions for the u irritable ” persons of high nervous tension, chiefly manifested by readily vulnerable mucous membranes and skins; the result of an equally irritable circulatory ap- paratus. 5. The colliquative—the breaking down stage of any case of phthisis ; the exacerbations no longer intermittent or remittent, but continuous, indicating great intensity of infection (acute tuberculosis) or of inflammation (suppura- tive peri-bronchitis). We may at once say that these man- ifestations of an early dissolution are not amenable to climatic treatment. All of the other forms will be benefited or cured by a change to a climate suitable to their respective manifesta- tions. Because of the evidences of general depression of vital forces manifest in phthisis, it has been taught until recently, and is to-day believed by a majority, that the two chief therapeutical elements required are warmth and moisture, the fosterers of equability of temperature; elements which constitute what is called a mild, soothing or seda- tive climate. This fact will be shown in connection with the publication of the collected opinions of the pneuma- tologists of this country. 296 Original Articles. [April, 1883. Dr. Jas. Henry Bennett,1 of London, has for a number of years -advocated the advantages of a cool, bracing and tonifying climate. This is well for a certain class of cases, but is going to the other extreme. First of all, let it be distinctly understood that no specific element which cures consumption, resides in any climate of any part of our globe, whether at land or sea, in the lowlands or at mountain altitudes. But it is no less an error to suppose that any benefit derived from change of climate is to be looked for only in the fact that the air is “pure and plentiful” and constitutes “nourishment to the lungs.” Nourishing of the lungs is carried on by the bronchial arteries, and not by that great net-work of pul- monary vessels which carry on the exchange of oxygen for carbonic acid, and thereby regulate our air supply. Air may be called pure when there is an absence of mechanical and organic admixtures, represented by dust and noxious gases on the one hand, and animal and vege- table germs on the other. (For the literature on this sub- ject see Tyndall on “ Floating Matter of the Air.” To the “ superficial,” above referred to, as well as to many phthisical patients in the more advanced stages, any change from city to country, from a marine to a continental climate, or rice versa, will be productive of temporary benefit. This benefit consists only in an increase of weight and a temporary amelioration of symptoms. In other words, the general condition will be improved, but the local lesion in the lung will remain in statu quo. The same benefit is reached by ocean voyages, which explains the cures reached by that method. Drs. C. T. Williams and Brelimer have observed that gain in weight bears no relation whatever to the local pro- cess in the limg. I have long been convinced that a mere gain in adipose tissue is a hindrance to absorption of in- 1 On the Treatment of Pulmonary Consumption—Jas. Henry Bennett, M. D. Tyndale.] Climate for Pulmonary Consumption. 297 filtration in the lung. And more than that; as soon as an increased ingestion of food has re-established the average weight and something of the sensation of strength to the patient—as soon as this trifling change has accomplished all it can do—the phthisical process will resume its onward march. Hence the fallacy of teaching that a patient should “remain in that locality as long as he continues to improve ” (Loomis), for by the time the patient recognizes his mistake he is far on the road to dissolution. Dr. Wil- liams1 says that this “demonstrates, only too faithfully, how all the appearances of an improved state of health may be present, and yet the disease may continue its in- sidious and steady march unchecked.” Consumptives require more than mere quantity and nor- mal quality of atmospheric air; it should be aseptic (not permitting of the development of infectious germs) or di- rectly antiseptic (antidotal to germ life), as it is claimed for the exhalations of pine forests, and, in a lesser degree, for the salt-air of the sea. What are the chief constituents of climate in general ? 1. Pressure of the air column (barometric pressure), in- dicative, among other things, of the degree of elevation. 2. Humidity of the atmosphere—relative dryness. 3. Temperature of the various months and seasons— the mean degree of warmth, and the question of range of temperature—indicative of its equability. These three: Dryness, equability and elevation, are the main constituents, the others being the result of the combi- nation of two of them, or resulting from the effects of one upon the other. a. Intensity of sunlight. b. Force, direction and frequency of winds. c. Electricity—its quality and tension. d. Precipitation of rain and snow. e. The production of ozone. f. Mechanical and organic floating matter. 1