SYPHILIS OF THE THORACIC ORGANS. Henry Alfred Robbins, M. D.} Washington, D. C. CLINICAL LECTURE DELIVERED AT THE SOUTH WASHINGTON (D. C.) FREE DISPENSARY ON MARCH 9, 1897. TWELFTH PAPER. Reprinted from the Maryland Medical Journal, November 6, 1897. This colored child, aged eleven years, makes the sixth that I have shown you in the last three months, who is suffer- ing from acquired syphilis. On exam- ination you notice, on the left labia ma- jora, an indurated papular chancre. The parts are not swollen, and no marks of any violence exist. There is no pre- cocious development, and you notice that the mons veneris is devoid of hair. There is a well marked bubo in the left groin, and well marked macular erup- tion over the abdomen. You will find on examination induration of the sub- maxillary, post-cervical, sub-lingual, post-auricular and epitrochlear glands. She has opaline mucous patches in her mouth, and she has alopecia, and she complains of nocturnal headache, and pains in her joints. Before dismissing the patient, Dr. Arwine will take her aside, and perhaps, with his customary tact, can obtain a history of how the child acquired the disease. He has returned alone, and says that this child, who is only eleven years old, has for the past two years allowed boys of all ages to attempt the sexual act with her. Some, she said, were sixteen and twenty years old, and these disgusting scenes occurred two or three times a week. It is not my pur- pose at the present time to dilate on the frightful lack of morality that exists among certain classes at the National Capital. The best informed know that our pa- tients are the poorest of the poor, lack- ing in food and raiment, and fuel to keep them warm. Still they will strug- gle to pay five or ten cents for medicines, showing that it is a base libel on the really deserving poor, to state that they are not anxious to pay. We weep over the sufferings of the poor in our com- fortable pews in a fashionable place of worship, as it exists in foreign capi- tals ; while under the shadow of the dome of our own capitol, there exists more want and disease and immorality than Eugene Sue described in his “Mys- teries and Miseries of Paris.’’ Before resuming the subject of syphi- lis of the internal organs, I can not refrain from quoting the following, which I have just read in the Medical Record of February 27, 1897: “ A good story is told of a rich manufacturer of foot wear and a poor (i. e., in the sense of not being rich) physician of a well- known European city. Mr. X. had a maxillary tumor, which, according to the Journal de Medecine de Bruxelles, a surgeon had agreed to remove for the sum of 14,000 francs. All was in readi- ness, when an intimate friend urged him to defer the operation until he could consult the young man who was fast gaining a reputation. Mr. X. con- sented. An antisyphilitic course of en- ergetic frictions and large doses of the iodides was entered upon, with such success that in a very short time the tumor had disappeared. In the mean- time the young physician, thinking to patronize those who came to him, or- dered at the establishment a handsome pair of shoes. On the first of the year the physician sent in his bill for 30 francs for the six office visits paid him. By return mail his bill came back, en- closed with one for 50 francs for the shoes. The question is, whether the patient would not have made the sur- geon a present of the shoes if he had been cut 14,000 francs’ worth.” sisted that syphilitic subjects died, pre- senting ‘‘phthisical appearances, with ulceration of the lungs, situated most frequently in the middle lobe, but with- out tubercle.” Ricord and I,anceraux and Alfred Fournier have, by pathologi- cal anatomy, proved that symptoms of phthisis are not only possible, but very frequently the same as those produced by syphilis. Syphilitic Broncho-Pneumonia. Drs. Balzer and Grandhomme have recently made several necropsies of syphilitic still-born infants, and the results of their examinations prove that syphilitic le- sions, which are caused by microbes, like other inflammations, do not appear to preserve any specific character in their evolutions. With regard to the lungs, syphilitic pneumonia may be classed with broncho-pneumonia, in the same degree as secondary pneumonia in acute infectious diseases, such as measles, or in chronic affections, like tuberculosis. Syphilis in the fetus as- sumes the different forms of broncho- pneumonia and other lesions, according to its violence and the degree of its chronic stage. The authors classify these forms of broncho-pneumonia, in- cluding pulmonary congestion, and le- sions which are not apparent on micro- scopic examination. 2. Broncho-pneumonia or agglomer- ated nuclei disposed in a vertical band at the posterior portion of the lungs. These forms correspond, with regard to lesions, to subacute forms of broncho- pneumonia of other infectious diseases, and invariably assume the following type. We have called your attention to syphilis of the brain, and of the organs of sight and hearing, and of smelling, and of taste. Likewise we have taken up the buccal cavity and the pharynx and larynx. Now let us take up the lungs. Lammonier nearly a century ago described the existence of phthisis pulmonalis of a syphilitic character. Then followed a long series of years when syphilis was not recognized as at- tacking the internal organs, probably owing to the teachings of John Hunter and Sir Astley Cooper, who did not believe in any visceral complications of syphilis. Sir Astley and Kdward Jen- ner were the pet students of Hunter, and naturally endorsed whatever the great physiologist taught. Sir Astley in his lectures on surgery taught “ that some parts of the body are incapable of being acted upon by the venereal poison, such as the brain, the heart and the abdominal viscera.” Indeed he writes ; “ This poison does not appear to be capable of exercising its destruc- tive influence on the vital organs, or on those parts most essential to the welfare and continuance of life.” 3. Broncho-pneumonia, with white hepatization, without dilatation of the bronchi, corresponding to the hepatiza- tion of other forms of broncho-pneumo- nia. It may lead to fibro-caseous or gummy degeneration. 4. Broncho-pneumonia, accompanied b}r dilatation of the bronchi. It may be said that pulmonary syphilis is identi- cal at different ages. At a meeting of the Moscow Derma- tological Society, Pospelow and Kon- trim (^Monatshefie furpraktische Derma- tologic, 1895) each reported two cases of In 1826 Laennec and Vandral recog- nised and described syphilis of the lungs, identical in its symptoms to those of phthisis pulmonalis. Van der Kolk in- 3 syphilitic pneumonia that yielded to treatment with mercurials. Hemopty- sis occurred in three of the cases, and fever with sweating was present in two. The lesion was localized at the apices. In one of the cases, tubercle bacilli were found in the sputum, and the pro- cess was believed to be tuberculous. Treatment with mercurial inunctions and sulphur baths, with a residence in Egypt, was followed by general im- provement and disappearance of fever,- cough and expectoration. The patient had been well for three years at the time of the report. In this case it is believed that the tuberculous affection was implanted upon the syphilitic pneu- monia, disappearing with the latter. its complete disappearance without leav- ing any traces, and its prompt cure by mercury. The lecturer is inclined to believe that the so-called secondary fever of syphilis may be in many in- stances explained by the existence of this kind of pleurisy, which in the pres- ence of indubitable signs of lues venerea is not suspected or sought for. In one- half of the cases bronchitis is present as well, this complication being probably due to the outbreak of a syphilide on the bronchial mucous membrane. Dr. Rendu, at a recent clinical lecture, presented an old woman who had for a long time been emaciated and cachec- tic, but without fever. The symptoms were ill-defined, some pain, stiffness of the limbs, without marked weakness or paresthesia, dyspnea on exertion, and for a short time a dry cough without expectoration. The respiratory and auscultatory phenomena were found nor- mal, anteriorly, but behind there was dullness over the right apex, with roughened prolonged expiration. There was a loud, rough, systolic murmur, together with a softer and more super- ficial one, but no symptom of cardiac insufficiency. The arteries were appar- ently healthy, the liver normal in size, and there was no albuminuria. There was a diffuse and characteristic syphi- litic melanodermia, and iritis of two years’ standing, nocturnal bone pains and headache. Her only previous ill- ness had been measles. It was pointed out that against tuberculosis was the long duration, the absence of expectora- tion, of rales, and of concomitant symp- toms. Syphilis does not usually attack the apices, although cases of this occur- rence are recorded. Syphilis and tuber- culosis may occur in association, and tuberculosis may attack a lung previ- ously syphilitic. From the absence of a history of acute pneumonia an indu- rating pneumonia could here be ex- cluded, The attack of measles was not considered adequate cause. As there were no other etiological factors, the changes in the heart and lungs were probably syphilitic. Great improve- ment followed the exhibition of mercury and iodide of potassium. Syphilitic Pleurisy. In the Presse Medic ale, of the 20th ultimo, M. Chan- temesse publishes a clinical lecture on the complication of constitutional syphi- lis. The subjects of the lecture were two men who presented the usual stig- mata of syphilis in the eruptive stage. In both there were discovered the phys- ical signs of pleurisy with effusion, and in one aspiration with a hypodermic syringe yielded a quantity of straw- colored serum. Both had rales, due probably to an eruption of roseola on the bronchial mucous membrane. M. Chantemesse had succeeded in col- lecting twelve similar observations of syphilitic pleurisy. Most of them were cases of dry pleurisy, but in either case the prognosis is favorable, resolution and absorption being the _ rule un- der specific treatment. M. Chantemesse treated his patients with intravenous in- jections of corrosive sublimate ; he nevertheless does not recommend this method, but would prefer intramuscular injections of red oxide of mercury dis- solved in sterilized olive oil. He says that he has never noticed any stomatitis during a treatment of several months, consisting of daily doses of four or eight milligrammes of the salt dissolved in one or two cubic centimeters of the oil. The specific character of the pleurisy is plain to M. Chantemesse from the fol- lowing peculiarities : Its bilaterality, the small amount of effusion, its con- comitance with the secondary eruption, 4 In lecture No. VIII, I referred to pa- tients of Abrahams and Bratnbilla and Fournier .and Ross. These patients were undoubtedly far advanced in pulmo- nary tuberculosis, when they acquired syphilis. They were put upon energetic anti-syphilitic treatment, which cured not only the syphilis, but the tubercu- losis. You will naturally ask if I do not think that the treatment destroyed the toxines of both syphilis and tuber- culosis, and the same treatment is indi- cated for both diseases. I have put this same question to eminent throat and lung specialists, and have been in- formed that the treatment has been tried, and the effects were baneful, un- less the patient had syphilis complicat- ing the tuberculosis. Syphilis of the Heart and Arteries.— Virchow describes syphilitic growths in the substance of the heart, and refers to those recorded by Ricord and Lebert. Ricord, in his Atlas, calls them “syph- ilitic muscular nodes in the substance of the heart.” They were found in the substance of the ventricles, and con- sisted of firm, cheese-like masses. There was a history of chancres and ulcerated tubercles of the skin. Debert reports that gummata were seen at a com- paratively early stage of development in his case, and were found in the wall of the right ventricle. There were tu- bercles of the skin, of the subcutaneous tissue, genital organs and bones of the skull. In Virchow’s case there were syphilitic gummata in the testicles. A few months ago, I visited the United States Army Medical Museum, and Dr. D. S. Damb showed me a path- ological specimen of a heart in which a syphilitic gumma was imbedded in the wall of the left ventricle. This speci- men was exhibited in Baltimore, at the Johns Hopkins University, and its nature verified by the pathologists there. For the clinical record, Dr. Damb re- ferred me to Health Officer W. C. Woodward, M. D., as the specimen was obtained from him when he was serving as coroner of the District. Dr. Wood- ward kindly sent me the following re- port : “ The patient came under my observation after death. The history was vague. Colored, male, thirty-three years old, a native of Virginia ; was found dying in bed about 5 o’clock one morning by his wife, who had been sleeping by his side. He had com- plained for some time of shortness of breath, and is said to have had night- sweats just previous to his death. There was, further, a history of con- tinued ill health, not borne out by the condition of the body, attributed by his family to a hernia. There was no external evidence and no history of syphilis. Deceased was a huckster by occupation.” At a recent meeting of the Clinical Society of Don don (British Medical Jour- nal), Dr. Duckworth reported the case of a strongly-built man, 35 years old, who, while walking in the street carry- ing his little boy, suddenly fell down and expired. Only a meager anteced- ent history was obtained, but there was evidence of old syphilitic disease on the tongue and on the glans penis. A small gumma was found in the left lung. The heart weighed twenty-two ounces, and was bound by firm adhe- sions to the pericardium, both at the apex and the base. The ventricles were hypertrophied -and dilated ; the valves were normal. In the wall of the left ventricle, above the apex, was a round depression, nearly an inch in diameter, and covered by long adhesions. This was due to a thinning of the wall, with much endocardial thickening. A large aneurismal pouch was found behind the In the Museum of the British Army, Medical Department at Netley, there are two preparations which show such gummata in the substance of the heart. “ One occurred in the case of a soldier, twenty-four years of age, under treat- ment for venereal ulcers, of nine month’s duration, in various parts of the body. He had lost his palate, and eventually sank from exhaustion, with symptoms of phthisis. Sections of the muscular substance of the heart showed several isolated deposits in its substance and beneath its serous covering, and isolated portions of the lungs were converted into a substance of the consistence of cheese.” 5 posterior cusp of the mitral valve. This appeared from without as a tumor grow- ing from the base of the heart, and com- pletely covering the left auricle. Its walls were half an inch thick, and the pericardium was closely adherent over it. On section the muscle was replaced by tough, fibrous tissue, with foci of gelatinous matter. The endocardium was greatly thickened and fibrous. Mi- croscopic examination proved the for- mation to be gummatous in nature, with patches of caseation. The smaller vessels showed signs of endarteritis. These appearances were taken to indi- cate a recent gummatous growth at the base of the left ventricle, and a similar but older one near the apex of that cavity. second and third intercostal spaces, with an accentuated second sound. There was no clinical evidence of syphilis. Eight days after admission, there was a profuse and fatal hemorrhage from the stomach. The autopsy showed the heart to be hypertrophied, but only slightly dilated. No circulatory obstruc- tion could be proved at the mitral ori- fice. Islets of fibrous tissue were pres- ent at the base of the papillary muscles, and the muscles themselves had under- gone fibrous changes. Fine strands of fibrous tissue were seen in the slightly brown cardiac muscular tissue. The dilated left auricle presented peculiar appearances. The wall was rigid, with only the remains of a few yellowish- brown muscular fibers. The auricular appendix was greatly shrunken. Very irregular and easily detached excres- cences were found in the inner wall of the auricle, and were especially marked well on the upper surface of the mitral valve segment. The gummatous formation in the heart muscle could only be due to syphilis. In the liver fibrous changes with the remainsofgummata were found. There was induration of the uterus with chronic endometritis, also of syphilitic origin. Investigation showed that in fourteen similar cases death occurred quite sud- denly in eight. But one case in the whole number was in a woman. The mean age of all the patients was 32 years. Many of the cases seemed to have been devoid of urgent symptoms. In some there had been pericardial pain. The valves were not usually involved, and hence murmurs were not to be heard. The ventricles and their septa were the common sites of the growth. The tendency to fatal and sudden syn- cope was probably attributable in part to endarteritis affecting the coronary vessels, and possibly to the formation of embolisms in the branches of the coro- nary arteries, as a result of the dislodg- ment of fragments from the interior of aneurisms. At the Berlin Medical Society, Dr. A. Fraenkel recently demonstrated a speci- men of cardiac syphilis from a woman 36 years of age. When first seen last year she had aortic regurgitation and suffered from frequent headaches, which were occasionally associated with faint- ing attacks. The heart disease was supposed to be consequent on acute rheumatism. The husband was syphi- litic and the woman herself had suffered from swellings on the head, which had ulcerated and left scars. She improved at first and left the hospital, but was re- admitted this year with severe attacks of angina pectoris, in one of which she died. At the necropsy the left coronary artery was found quite permeable, but the orifice of the right coronary was completely obliterated by a process of arterio-sclerosis, which in excess of the patient’s years and its proper position could only be determined by probing backward along the lumen of the artery. During a recent meeting of the Mon- treal Medico-Chirurgical Society, Dr. Finley presented the report of a case of syphilitic gummata of the heart and liver, and exhibited the pathological specimens showing the characteristic lesions. At a late meeting of the Charitfe Aerzte of Berlin, Dr. Israel exhibited pathological specimens, and gave the following clinical history ; During life the patient, aged 47, had presented the appearance of hepatic cirrhosis. The pulse, 136, was small and irregular at first, but improved under digitalis. A svstolic murmur was heard in the left, 6 There was a gummatous tumor, four and a half centimeters long, in the sep- tum ventriculorum, and Fraenkel thinks this shows that the arterial changes were really of syphilitic nature. The arterio-sclerotic changes in the aorta reached down to the bifurcation. Fraen- kel, moreover, remarks on the part played by syphilis in the etiology of aneurisms. Walsh thought that sixty per cent, of true aneurisms were due to syphilis ; others think still more. Fraenkel himself, during the last four years, has seen nineteen cases of aneu- rism of the thoracic aorta in which there were necropsies. Three cases were in women, sixteen in men. Of the nine- teen patients, nine, that is forty-seven per cent., had had syphilis and these were all under fifty years of age. The case illustrates the relation of precocious arterio-sclerosis and syphilis. Mracek {Medico- Chirurgisches Centralblatt, 1895) refers to authors and states that, espe- cially just preceding the roseola, in the second stage of syphilis, disturbance of the heart’s action is not uncommon. He quotes Fournier to the effect that these troubles are functional and not de- pendent upon distinct lesions of the heart itself, and that they are distinctly transitory by nature, disappearing with- out leaving a trace, occurring much more frequently in women, and com- monly associated with nervous disturb- ances. The later forms of heart syphilis appear, however, as distinct pathologi- cal changes. The symptoms of the af- fection are those of degeneration of the heart-muscle or interference with the valves, whatever is the cause of these pathological conditions. but rather a slow transformation in the fibrous tissue. Judging from reported cases the prognosis is extremely bad, death coming suddenly and often in the midst of apparent perfect health. In sixty-three cases collected by the author (Semnola), this suddenly occurred in one-third of the number. Jullien and Mauriac stated that this end is observed in fifty per cent, of cases. Death comes after a heavy meal, or from drinking or straining. Often the patients are found dead in bed. Many cases perish in coma from heart failure. Dr. Fisher, in the Bristol Medico- Chi- rurgical Journal, summarizes as follows the articles of Hektoen (Journal oj Pa- thology and Bacteriology) and Jacquinet ('Gazette des Hopiiattx, 1895): “Hek- toen records a case of interstitial myo- carditis due to syphilis in a child six weeks old and mentions that only eleven other cases have been recorded. In two of these eleven cases sudden death oc- curred when the children were consid- ered to be in good health, a noteworthy fact, siiice it shows that this disease in the child may lead to the same abrupt arrest of heart action that frequently oc- curs in the adult when the heart is affected with syphilis. “Jacquinet treats the subject of syph- ilis of the heart very fully. In connec- tion with the above remark it may be mentioned that he quotes Mracek as saying that of fifty-eight cases of syphi- lis of the heart, twenty-one ended in sudden death. Others terminated in what French writers call acute asystole, where severe dyspnea ushers in the rap- idly approaching end. Jacquinet quotes as an example the case of a prostitute who was dining in a beer-house with some of her companions, when she com- plained of pain in the stomach and ab- domen. The pains increased and palpi- tation of the heart was added. She was removed to a hospital and died of “ advanced asphyxia ’’ after a few hours. The pain mentioned in this case suggests angina pectoris, which may sometimes be epigastric in situation. Jacquinet comments upon this point and refers to the possibility of cardiac pain being a symptom of syphilis of the heart. He Semnola holds as pathognomonic a persistent arhythmia, either existing alone or accompanied by tachycardia, respiratory troubles coming and going, resistance to all ordinary methods of treatment, and a history of syphilis. Through syphilitic stenosis of the coro- nary artery the symptoms of angina pectoris may be caused. Exceptionally, murmurs are developed. The course of syphilis of the heart is extremely slow and insidious. There is rarely any acute process, such as a softening of a gumma, 7 mentions that one of the recorded cases of sudden death occurred in a sailor, who died putting his hand to his heart as if he suffered pain in that region. Huchard is quoted as saying that of no cases of angina pectoris, in 32 a history of syphilis was obtained, and other ob- servers are mentioned as having noticed severe cardiac pain in syphilitic subjects. This point is of some interest, since po- tassium iodide is recognized as of value in angina pectoris. The drug is not gen- erally given, however, with the idea of combating syphilis, but of influencing the diseased condition of the coronary arteries that often exists. Yet a satis- factory result naturally suggests that this disease of the coronary arteries may be sometimes syphilitic, like aortitis of the intra-pericardial portion of the aorta with which cardiac pain is also often associated.” that did not terminate suddenly were in young prostitutes. One of these died with intense dyspnea and c}?anosis ; the other was admitted to the Bellevue Hos- pital for lobar pneumonia, which ended fatally. Dr. Loomis emphasizes the point that the question of syphilis as a probable cause of heart disease should not be overlooked. He says : “ When symptoms of cardiac failure occur dur- ing the prime of life, for which no cause can be ascertained, such as rheumatic history, valvular disease, arterial changes or kidney complications, especially in one with a syphilitic history, these should always suggest syphilis as the cause of the condition.” The same author published in the American Journal of the Medical Sciences, October, 1895, a very able and instruct- ive article, giving in detail his services as curator for ten years for Bellevue Hospital, New York City. Fifteen hundred or more autopsies came under his personal observation, where certain pathological changes, “ which were un- questionably of syphilitic origin, yet which failed in spite of marked symp- toms to be diagnosed during life as man- ifestations of syphilis.” We propose in our next lecture to take up syphilis of the liver, spleen, kidneys, and conclude with a lecture on treatment. Dr. H. P. Loomis has reported fifteen cases of fibroid disease of the heart, three of which were considered beyond all doubt to have been of syphilitic ori- gin. He has also seen four cases of gummata of the heart wall. Sudden death occurred in two of these cases. Notes are given of one. An apparently healthy man, aged 35, was found lying dead on his bedroom floor, with his hat in his hand, having obviously fallen immediately after entry. The two cases