REPORT ON EPIDEMICS. REPORT ON THE EPIDEMICS OF LOUISIANA, MISSISSIPPI, ARKANSAS, AND TEXAS, FOR THE YEARS 1854 AND 1855, TO THE * AMERICAN MEDICAL ASSOCIATION, AT THE ANNUAL MEETING IN DETROIT, MICHIGAN, MAY, 1856. BY ERASMUS D. FENNER, M. D., OF NEW ORLEANS. EXTRACTED FROM THE TRANSACTIONS OF THE AMERICAN MEDICAL ASSOCIATION. PHILADELPHIA: T. K. AND P. G. COLLINS, PRINTERS. 1856. CONTENTS. PAGE Malignancy of the Yellow Fever of 1854 and 1855 7 Range of the Fever widening year by year ....... 8 Circumstances which seem to prove its contagiousness . . ' . . . 9 Epidemic of 1854 ............ 11 Epidemic of 1855 ............ 15 Pathology and treatment of Yellow Fever 22 I. Quarantine and Yellow Fever at Natchez during 1853-'54 and '55 : the futility of the former and the local origin of the latter conclusively shown; and admitted for 1855, by the most strenuous advocates of the one, and the most ardent disbelievers of the other. By C. H. Stone, M. D., of Natchez 27 II. On the Yellow Fever of Woodville, and its vicinity, in the State of Mississippi. By Alfred C. Holt, M. D 37 III. Yellow Fever in the Country: An Account of the Disease as it pre- vailed at Judge Baker's Plantation, Parish of St. Mary, Louisiana, in September and October, 1854. By C. R. Fassitt, M. D. . . .46 IV. Yellow Fever in the Country: An Account of the Disease as it prevailed on the Coast below New Orleans, in 1854 and '55. By D. R. Fox, M. D 49 V. A Report of the Yellow Fever at Centreville, in 1855, with some Re- marks on the Disease as it appeared in the Parish of St. Mary, in 1853, '54, and '55. By Wm. B. Wood, M. D 55 VI. Yellow Fever in Thibodeaux, La., in the year 1854. By M. A. McLeod, of Thibodeaux 66 VIL An Account of the Epidemic Yellow Fever at Cooper's Wells, in Hinds County, Miss., during the Summer and Autumn of 1855. By J. S. Beazley, M. D. 69 VIII. On the Topography, Climate, and Diseases of Washington, Texas. By T. J. Heard, M. D 74 IX. Yellow Fever at Jeanerrett's, Parish of St. Mary, La. By J. B. Dungan, M. D 81 X. Yellow Fever at Brandon, Mississippi, in 1853 and 1854. By J. J. Thornton, M. D 83 XL Yellow Fever at the Village of Cloutierville, La., in the years 1853 and 1854. By S. 0. Scruggs, M. D. 88 On the Yellow Fever of Noi-folk and Portsmouth, Va. By E. D. Fenner, M. D. 95 APPENDIX. REPORT. The reporter of the American Medical Association, on the Epi- demics of the above named States, after expressing his regret at not having been able to perform the duty assigned him, for the year 1854, now respectfully submits the following facts and observations relative to the two principal epidemics that have prevailed in this region during the two years 1854 and 1855. It will be seen that the bulk of this report is made up of contributions kindly fur- nished by my professional friends, to whom I must be allowed the privilege of thus publicly expressing my grateful acknowledg- ments ; for without this material aid it would have been impossible for me to have prepared a satisfactory report, on account of the numerous and pressing engagements upon my time. Yellow fever and Cholera are the only epidemics to which we invite attention; and especially the former, as it has been the most extensive in its range, and most fatal in its effects: the latter (cholera), may be passed over with a few general remarks at the close of this report. I feel authorized to say the yellow fever of the last two years in New Orleans was fully as malignant as the memorable epidemic of 1853, and the sufferers and victims would have been equally nume- rous, if there had been as many susceptible subjects exposed to it. When we recollect that upwards of twenty thousand people in this city suffered and survived the fever of 1853, it will readily appear that the epidemic influence in the last two years must have been very severe, to have caused about 2500 deaths each year. At some other places in my district this disease prevailed with equal malignity; as in Galveston, Texas, in 1854, and in Vicksburg, in 1855. It is a fact worth mentioning, that the city of Galveston, a seaport directly on the Gulf of Mexico, and in constant communication 8 with New Orleans and Houston, Texas, escaped this epidemic in 1855, whilst both of the cities named were severely scourged, and this too, without the supposed protective agency of Quarantine. It was remarked, in my last report, that the area or range of yellow fever was evidently enlarging from year to year. Subse- quent observations furnish farther evidence of this fact. For in- stance-the highest point on the Mississippi River at which the epidemic of 1853 prevailed, was the little town of Napoleon, about two hundred miles above Vicksburg, and the same distance below Memphis. In that year, upwards of sixty cases of the disease were carried into Memphis, and more than forty of them proved fatal, no effort whatever being made to isolate the disease, yet the citizens of the place did not suffer in the least. It would not prevail there at that time; but, strange to say, in 1855 the disease broke out there, and prevailed as an epidemic, the first cases being traced by Dr. Shanks to a steamboat plying between that place and New Orleans. Memphis is a city of about 15,000 inhabitants, situated on a high bluff, and was thought to be secure against the yellow fever of New Orleans, from the fact that hundreds of cases had been brought there without any injurious effect upon the citizens. Nevertheless, we have the reliable testimony of the late Dr. Wyatt Christian, of Memphis, for stating that, in 1828, when the place was only a small village, yellow fever did break out near a large pile of decaying cotton-seed, and prevailed to the extent of forty or fifty cases. The offending cause was then removed, and the disease vanished ; so that some change must have recently taken place in the locality of Memphis, which either caused the disease to spring up spontaneously, or furnished a nidus favorable to its regeneration and extension when once introduced from abroad. Yellow fever has also extended, in another direction, further than it ever did before-I mean the interior of the country, remote from the great river. In 1854, the village of Brandon, in Mississippi, the terminus of the railroad leading from Vicksburg, and about sixty miles distant from that place, was severely scourged for the first and only time. Brandon is situated in a high pine region, and the only recent change that has taken place in the locality was made by the deep cuts for the railroad. This road runs through Jackson, the capital of the State, which has been scourged by yellow fever for the last three years. Likewise, the village of Canton, about twenty-four miles from Jackson, and seventy-four from Vicksburg, was severely scourged in the summer and autumn of 1855. The 9 railroad has been recently extended from Jackson to this place, though it was not completed at the time yellow fever prevailed. Besides the cuts into the ground necessary for the railroad, I learn there was a brick yard in the town, which made a large pool of stagnant water, that may have had some agency in producing disease. The valu- able contributions to this report obtained from my correspondents in different parts of the district, will be found to contain much in- teresting information relative to the behavior of yellow fever in the interior of the country. The authors of these papers appear to differ in regard to the origin and transportability of the disease, but the reader may form his own conclusion from the facts given. In my last report, I expressed the belief that yellow fever was one of the forms or varieties of endemic fever that originates spontane- ously in New Orleans, and most generally, was not at all infectious, or capable of being transported to distant and dissimilar localities, and there communicated to the resident population without the assist- ance of any other deleterious influence. At the same time, it was admitted that many occurrences of recent date in this region, tended strongly to prove that the materies morbi could sometimes be conveyed from an infected to a healthy locality, where, most probably, it would not originate, and then be communicated from person to person like measles, scarlatina, and hooping-cough. This is the doctrine of " contingent contagion," so strongly opposed by the distinguished Dr. La Roche, of Philadelphia. I confess it is contrary to my first convictions as well as to all my observations up to the year 1853, but I trust I shall never become so bigoted in any belief that I cannot possibly be con- vinced of its fallacy, if it should be false, as is liable to happen in all human judgments. Dr. Rush once proclaimed the belief that yellow fever was an imported and contagious disease, but afterwards acknowledged his error and obtained much credit for magnanimity, by openly recanting a published opinion. In like manner I have but little doubt that if Dr. La Roche had spent the last three sum- mers in this region, he would have found sufficient cause to modify his opinion on this point. It is well known that since the days of Rush the non-contagion of yellow fever has been the doctrine of all American Professors, with the exception of the late Dr. Hosack, of New York, and Dr. Dickson of Charleston. And this is the doc- trine that was instilled into the mind of nearly every physician now practising in this region; but an extensive intercourse with the 10 profession leads me to say, in all candor, that the experience of the last three years has greatly modified opinion on this subject. Some physicians still deny, in toto, the contagion of yellow fever; but I think the majority of those who have recently been brought in contact with it in this region now admit, that under favorable circumstances and within a limited region, the morbific cause may be conveyed from one place to another, and take effect upon persons thus exposed to it. The mass of the people who have been the sufferers, are almost unanimous in this belief. But, to the philo- sophical inquirer after truth, is presented an array of facts appa- rently of the most contradictory character in relation to this ques- tion. Why should the disease be contagious at one place and not at another ? in one season and not another ? Why should it now prevail epidemically, for the first time, at a town or plantation on the Mississippi River, which has always been in direct communica- tion with New Orleans, and into which cases of the disease and all sorts of goods have been introduced from an infected district, hitherto, with impunity ? Formerly, when it broke out at one of its old habitats, as New Orleans, Mobile, or Natchez, cases might be taken thence into the neighboring country, without endangering the in- habitants ; but not so now. It seldom fails to spread when taken to the neighborhood of these places. When the disease now breaks«out for the first time at a town far up one of the navigable streams, the inhabitants flee with conster- nation to the surrounding country, carrying in their systems the seeds of infection, which then mature and develop the fatal fever, but incapable of spreading among the attendants on the sick; but perhaps a like impunity will not be observed a few years hence. Such are some of the curious and apparently antagonistic facts that require to be reconciled and explained before we can claim to un- derstand the true nature and character of yellow fever. After the great epidemic of 1853, the citizens of Louisiana were so fully persuaded of the foreign origin and contagiousness of yellow fever that they loudly demanded of their Representatives in the Legislature to establish quarantine for the protection of New Orleans and the interior of the country against the incursion of their in- sidious enemy. The effort was made at the Session of 1854, which took place in January and February, but failed for want of proper management by the advocates of the measure. In the following summer the disease again broke out in this city and prevailed with 11 terrible malignity. At the succeeding session of the Legislature quarantine was established, and has been enforced ever since. We will proceed at once with an account of the rise and progress of the last two epidemics in New Orleans. On the 8th of April, 1854, a lady arrived here from Havana, in the last stage of yellow fever, with which she had been attacked soon after getting out to sea. She was taken to the St. Louis Hotel, one of the largest in the city, and died on the following day, with black vomit and yellow skin. It had no injurious effect whatever upon the inmates of the house. The next case pronounced yellow fever was of a somewhat ques- tionable character. It occurred in the upper part of the city, near St. Mary's Market, in a man of rather intemperate habits, who had been about the city four or five years, running in and out on steam- boats, but had never had yellow fever. He was employed painting a steamboat on this side of the river when he was attacked with fever. Had nothing to do with ships. He died on the 18th of June, and ninth day of illness; he threw up something very like black vomit, and the body turned yellow. The case is only considered questionable from the fact that it had been treated by a physician of not very fair standing, who had given it large quantities of brandy and morphine, which may have caused gastro-duodenitis and effu- sion of blood from the mucous membrane. It thus appears that this case occurred more than two months after the case at the St. Louis Hotel, and about a mile distant. The next, and probably the first unquestionable case, was admit- ted into the Luzenberg Hospital, on the 17th of June. The subject was a robust German aged about 30 years, who had been in this country three years, mostly engaged on steamboats running from New Orleans to St. Louis and Louisville. Arrived here from one of the latter places on the 12th of June, and stopped on Fulton Street, between 8th and 9th Streets, which is high up in the Fourth District, or Lafayette. He was attacked on the 16th of June, and entered the hospital on the 17th, as above stated. He died on the 4th day of illness, after throwing up large quantities of black vomit, and the body turned yellow. Dr. Langenbacher, the resident phy- sician, had no hesitation in pronouncing it a genuine case of yellow fever. So here is a case occurring at least a mile distant from the last one, and taken sick very soon after coming into the city, not from an infected place or vessel, but from the upper country. We are indebted to Dr. Langenbacher for notes of the following cases, which were amongst the earliest that occurred this summer. 12 Case.-A German girl, who had been in the city seven months, and lived at 74 New Levee Street, between Notre Dame and Girod, near the river, and about midway the length of the city, was brought to the Luzenberg Hospital, on the 24th of June. She proved to be a plain case of yellow fever; had severe hemorrhage from the nose, and the eyes turned yellow-recovered. Case.-A German servant girl, aged 17 years, residing on Jeffer- son Street, not far from Jackson Square-been in the city about six months; was taken to the Luzenberg Hospital on the 29th of June, and died with black vomit on the 2d of July. Case.-I. S., a German baker, aged 32 years-been in the city six months-resided on Fourth Street near Rousseau-was brought to the Luzenberg Hospital on the 30th of June; then sick three days-began to throw up black vomit the evening of the day he entered, and died on the following day (July 1st), with black vomit and hemorrhage from the bowels. This man had lived high up town, worked constantly in the Louisiana Bakery, and never went about delivering bread in the city, or on board of ships. Cases Imported From Havana.-On the same day the case last given entered the hospital, a Spanish sailor was admitted into the same room, in the last stage of yellow fever. lie was brought from a vessel which had just arrived from Havana, with several cases of yellow fever on board. This man died on the 3d of July. Several other cases were admitted from the same vessel, which lay near the lower Cotton-press, at least two miles below the place where the case last given originated. It is nevertheless true that immediately after the Havana vessel arrived, yellow fever broke out in the adjacent shipping, and became epidemic in that part of the city, long before it did in the upper part, where the first cases occurred. What agency the vessel had in bringing about this event, is left for the reader to judge. It is due to the truth of history to say, however, that yellow fever epidemics do not always break out in the same part of the city, but sometimes in one and again in another. We have already shown that there had been unquestionable cases of yellow fever in the city before the arrival of this vessel from Havana. On the 30th of June, I was informed by Dr. W. that he had seen several cases around Gormley's Basin, in the rear of the city, where some of the first cases occurred in 1853. At a meeting of the Physico-Medical Society on the 3d of July one of the members stated that he had recently seen a case of 11 gas. iritis1'1 terminate fatally with black vomit. 13 First Case at the Charity Hospital.-L. II., a German seaman, aged 22 years, was admitted into ward 22 on the 13th of July. Said he came last from Rio Janeiro, where he had remained a month. Six weeks ago he came to New Orleans on board the ship Caroline, and was not attacked until he had been here five weeks, viz., on the 8th of July. The case was almost hopeless when admitted, and died on the 14th of July with copious black vomit. The next case admitted into this hospital was on the 22d of July. The next on the 24th of July. On the 28th there were eight cases in the house, and by the 1st of August the number of admissions got up to 36. The disease increased so rapidly that in the month of August the admissions amounted to 683, and in September to 1291. From that time it steadily declined. But let us turn back a little to some more imported cases. On the 14th of July the barque Tonquin, Captain Hill, arrived here from Baltimore, having called and remained a week at Havana, where there was a great deal of yellow fever, especially among the shipping. Captain H. left there on the 1st of July. Soon after getting to sea, fever broke out on board, but not very malignant. Captain H. was attacked the day he got into New Orleans, and had a pretty severe spell. As before stated, the disease was prevailing here when this vessel arrived; she took position in the Fourth Dis- trict, below Jackson Street, but I could not trace any injurious effects directly to it. The disease did not become epidemic in that district until about three weeks after her arrival. So much for the origin and commencement of this epidemic, which finally overran the whole city, and proved as fatal in propor- tion to the number attacked as that of 1853. I leave the reader to judge from the facts given, which were collected carefully at the time of occurrence, whether the disease originated in the city or was imported from abroad. My own opinion is that it originated from local causes belonging to the city, and in precisely the same manner that it always originates here. After the middle of May, in this city, the milder forms of fever (intermittent and remittent bilious) gradu- ally run into the yellow fever type which, if the season be a very sickly one, gains complete ascendence, but does not supersede en- entirely all others, and reigns for a period of seven or eight weeks; then gradually falls back again into the milder types, and disappears after cold weather sets in. The following table will sufficiently prove the truth of this observation. 14 Table showing the number of Fever Cases of all kinds admitted, monthly, into the New Orleans Charity Hospital, during the year 1854; also the ad- missions for all diseases during the same period. 1854. FEVERS. January. February. March. April. May. June. July. August. September. October. November. December. 3 © Intermittent 258 130 156 129 101 140 222 212 186 245 190 203 2172 Remit, bilious 18 20 14 11 12 66 70 97 17 52 49 29 455 Continued 3 2 3 1 6 9 4 2 1 5 3 39 Typhoid 38 20 12 13 22 12 15 10 7 22 29 37 237 Typhus 7 5 3 8 7 ... 2 2 ... 4 13 51 Congestive ... ... 1 3 1 ... 2 7 Ephemeral 5 3 2 3 3 4 io 17 10 6 8 2 73 1'ernicious 2 2 2 1 3 2 10 6 5 33 Scarlet 2 ... 1 1 3 2 ... 2 1 ... 3 15 Inflammatory ... 2 2 1 2 5 5 6 ... 3 ... 26 Cerebral ... 1 ... 1 2 Rheumatic ... 1 1 2 1 1 7 13 Gastric 12 18 7 11 14 12 74 Nervous ... ... 1 ... 1 15 6 23 Chagres 1 2 ... ii 8 1 3 26 Catarrhal ... 1 5 2 7 4 1 20 Yellow ... 36 683 1291 606 133 5 2754 All fevers 334 186 196 168 156 256 401 1065 1530 951 461 316 6020 All diseases 1092 720 774 669 675 783 964 1664 1902 1454 1188 1318 13203 It will be seen that nearly half the cases admitted into the hospital this year, were fevers; and of these, more than one-third were inter- mittents. During the three months that yellow fever prevailed epi- demically, nearly one-third as many cases of intermittent and re- mittent fever were admitted. I have repeatedly shown that yellow fever never breaks out suddenly here, presenting its characteristic features from the first; but, on the contrary, that the first cases are generally of a very doubtful character, looking so much like bilious remittent fever that physicians cannot be brought to agree on the diagnosis until a number of cases have died with black vomit. It will be remembered, that the first cases of this year were observed in different parts of the city nearly a month before any case was admitted into the Charity Hospital; and particular attention is in- vited to the number of admissions for intermittent and remittent bilious fevers about the time that yellow fever appeared, and during its entire prevalence, as shown by the table. This is the case in New Orleans every year. It will be seen, further on, that my correspond- ent, Dr. Beazly, of Mississippi, noted the same thing in the epidemic at Cooper's Wells. 15 The total mortality, in the whole city, for this year, was 11,347 : of which there died of yellow fever 2,316, and of cholera 880. From New Orleans, as a starting-point, yellow fever spread far and wide into the interior of the country, the attendant circum- stances appearing to support the opinion that it was conveyed from place to place, and communicated by infection. At the close of this epidemic, the popular call for the establishment of quarantine was so general and urgent, that a law was passed for this purpose at the next session of the Louisiana Legislature, which met in January. How far the hopes and expectations of the advocates of this measure were realized, will appear from the occurrences which are about to be detailed. It is proper to state, however, that those of us who believed in the local origin of yellow fever, and expected no benefit from quarantine, withheld all active opposition to the measure, and were willing to give it a fair trial. It was evident that the public mind was so strongly biased in favor of it, that nothing else would be done to protect the city against the ravages of this pestilence until quarantine had been fairly tried. The law was put in opera- tion on the first day of June, 1855, and it must be confessed that the importation of yellow fever from abroad was entirely prevented; nevertheless, we were again scourged by a severe epidemic. EPIDEMIC OF 1855. The editors of the Medical News and Hospital Gazette (August, 1855), have furnished so full and correct an account of the first cases of this epidemic that I cannot do better than insert it entire. "Yellow Fever.-In the June and July numbers of our journal we reported all the genuine cases of yellow fever (eleven in num- ber) which had occurred in the Charity Hospital up to June 25th. Our readers may rely on the data furnished, inasmuch as we promptly rejected all cases in relation to which there was any real doubt as to the nature of the disease, and we have thus been able to furnish them the most ample and reliable material on which to exercise their speculative propensities-more complete and more reliable than can be found elsewhere, as we recorded our notes at the bedside of the patients, and accepted nothing second-handed. "Just at this time, when the great question of quarantine is agitating the public mind, the most interesting question connected with these cases relates to their origin, and in reviewing them we shall 16 merely advert to facts, without intruding our individual opin- ion. Every intelligent mind will make its own inference at last, and to afford the material for this purpose is our peculiar pro- vince. "In our June number is reported the case of John Hailey, who entered the Hospital on April 30th and died on 3d May. He seems to have been taken sick on his way down to the city on board a steamboat (either the Louisa or Rapides), on which he acted as cook. He was a native of Ireland and unacclimated. Yellow fever was not suspected at the time of his illness, and he was considered a case of "bilious fever" until black vomit made its appearance. No autopsy ever revealed more clearly all the characteristics of genuine yellow fever. Although the evidence is not positive, still, all the data tend to show that the individual had no communication with the shipping; he was taken sick away from the city, though he was running to and from the same every ten or fifteen days on one of the boats named. " The excitement caused by the case of Hailey in the Hospital soon subsided; none of the patients in the ward where he died took the disease, and things went on quietly until the 19th June, when a very severe case entered ward 22, and died on the 20th, after having thrown up black vomit profusely. This man's name was William Barneman-German-aged 21 years-one month in New Orleans-from Girod Street-worked on the levee for steamboats- taken sick on the 15th June. Autopsy revealed plenty of pure black vomit in the stomach. " However, by reference to our reports in July number, it will be seen that a case of yellow fever, Carl Draugod, really appeared in the hospital as early as the 15th of June. lie was seen by the visiting physician of the ward for the first time on the morning of the 16th, and although suspected at the time, nothing was said about it until the morning of the 19th, when he was bleeding freely from the nose-having, also, bled from the gums quite freely on the 18th. or the fifth day of the disease. All who saw this case pronounced it yellow fever. "Thus, then, the man Draugod (of June 15th) was the first case that appeared in the hospital after the case of May 3d, or forty-three days previously. Let us see who Draugod is:- " He is a native of Germany, from Liverpool direct, and had been in this city five weeks when taken sick-had been acting as servant 17 in the beer saloon of Frank Weber1 ever since his arrival, and had no connection with ships. During this man's illness in the ward sundry cases of intermittent and remittent fever, diarrhoea, etc., have occupied the beds around him, but none took yellow fever. "There is no evidence, then, of Draugod's having 'caught' the disease from any person or bale of goods, etc.; he was not only the first recorded case for the month of June, 1855, but he was simply an unacclimated German, thrown amongst us at the beginning of our summer season, and notwithstanding he worked within doors and was not exposed to the vicissitudes of the weather, we find him taking yellow fever in its hemorrhagic form at a very early date- he having been sick two days before he entered the hospital. "We next come to the case of Andreas Benz-German-in America three years-in New Orleans three weeks-last from Louisville, Ky. This man is a carpenter by trade, and was last at work near St. Mary's Market-entered ward 23 on 19th June-had been sick with diarrhoea nineteen days, and entered the ward with fever and diarrhoea. Died June 21st. "On the same day that Benz entered (June 19th), John Kramer entered ward 24. This man was a German-aged 23 years-five years in America-six months in New Orleans-common laborer, but had been working in Murphy's Hotel, on St. Charles Street (next door to the St. Charles Theatre), for two weeks previous to being taken sick. He distinctly avowed that he had no communi- cation with the shipping. Recovered. " These two individuals, then (Benz and Kramer), are found enter- ing the hospital on the same day--one from a carpenter's shop near St. Mary's Market (one of the filthiest portions of the city), the other from St. Charles Street, in the very heart of the city, and where most attention is paid to cleanliness. Both were strictly un- acclimated; one in the city but three weeks, the other six months. "Next comes Edward Tilden-Irishman-has been in America nine years, but has never resided in New Orleans-has been run- ning to and from the city on steamboats for several years-entered ward 25 on June 20th, having been taken sick four days previously (16th)-was taken sick on his boat and went thence to a boarding- house on Levee Street. It is thus seen that Tilden was one of the 1 The patient being a stranger in the city, could, not tell us the name of the street on which Weber keeps his saloon, though he says it is not near the shipping; and. we have failed to find it in the City Directory. 18 first taken sick, he being only three days behind our first patient, Draugod. ''Three days now elapse, and on the 23d June we find the man Philip Lyskchyler entering ward 22, with an intense attack of yellow fever, which terminates fatally on the morning of the 24th. He is a German-direct from Havre, on ship Rome,1 and has been in New Orleans but three weeks-has been working on the levee, near post 24-taken sick three days before he came in, or on the 20th June. "Next comes George Weintz-German-entered ward 22 on the 20th June. He is, also, from ship Rome (emigrant), and says he knew Lyskchyler well-has been sick twenty-four hours-is from a boarding-house near St. Mary's Market-has been doing nothing since his arrival in this city-merely lounging about his boarding- house. Recovered. "These two men (Lyskchyler and Weintz) were also wholly un- acclimated, having been in New Orleans but three weeks. The former was laboring on the levee in the sun, the other was under shelter and doing nothing; yet both took the disease. "We now come to Maria Shualtz, who was brought to the hos- pital in a hopeless condition on the morning of the 25th June. She could give no account of herself, but her friend says she is a native of Germany-has been in New Orleans eight months-is from the corner of Claiborne and Poet Streets (Third District, and far back from the river), and was taken sick on 22d June. This patient came from a locality far removed from any of the other cases, and a great distance back from the river, and, consequently, from the shipping. "Lastly, we have the man Joel Shoemaker-native of Ohio-in New Orleans six months, though recently returned from a visit to Ohio-lives in Lafayette, at a hotel near the Stock Landing-enter- ed ward on afternoon of 25th June, and died 2d July. This man and Maria Shualtz entered the hospital on the same day-both intensely attacked-yet coming from opposite ends of the city, and one from the river bank, the other from the rear of the city. 1 We are indebted, to Dr. Fenner, of this city, for the following notes in relation to ship Rome, he having visited her in person: " Ship Rome, Capt. Moulton- American vessel-arrived from Havre direct on 3d June, 1855-was hailed at qua- rantine, June 2d, examined and passed-brought but little cargo and 162 German emigrants-had little sickness at sea, and this confined to children, seven of whom died. Most of the emigrants left for St. Louis, June 4th. Capt. M. has now but one man on board-no sickness, and has heard of none in the neighborhood of his vessel. Ship Rome lies at post 24. about three squares above St. Mary's Market." 19 "The data being now furnished, it remains for those who preach the doctrine of the importation of yellow fever into New Orleans to make out their case. We cannot close, however, without annex- ing a summary of two cases which we regard as closely allied to the subject: they will speak for themselves:- "June 15th. Pan Mordin-Swede-entered ward 17-he is a clerk-last from Chicago-five months in New Orleans. This man was entirely delirious, and presented all the symptoms of delirium tremens-fever arose on the day after his admission, and on the 19th he died of as pure black vomit as was ever seen. "June 17th. Herman Ferringer-German-aged 20 years-last from Chicago-in New Orleans six months-entered ward 22- occupation, brewer-presented all the symptoms of "pernicious intermittent fever," but died on the 19th with some symptoms of yellow fever-so decided as to lead to the prediction that black vomit would be found in the stomach after death. The autopsy revealed genuine black vomit in the stomach. " Health of our City-July 25th, 1855.-The 25th of July has arrived, and we find ourselves again called on to render an account of the doings of disease in our city during the past month. Our last report was anything but a flattering one, and we had hoped to be able, this time, to present our readers a more agreeable pic- ture. To some extent these hopes have been realized, though there is nothing in our existing condition which can be construed into cause for self-gratulation. Our last report showed us to be just emerging from an epidemic of cholera, which had, in a few short weeks, killed near eight hundred of our citizens, in addition to a large mortality by other diseases. Since the issue of that report, the number of deaths by this disease have gradually declined, until it has almost disappeared-there being but 8 deaths reported for the week ending July 22d. In our last issue, however, we an- nounced the appearance of yellow fever here by reports of ten un- doubted cases which had been seen in the Charity Hospital. Since that time the disease has steadily increased, until for the week end- ing July 22d we notice 119 deaths from yellow fever alone. Up to the present time the total number of deaths by this disease re- ported is 201-to July 1st, 6; for week ending July 8th, 32; for week ending 15th, 44; and for week ending 22d, 119. " Concerning the origin of this disease for the present season we have treated elsewhere. So far as we are capable of determining, there appears to be nothing approaching a uniform type; we have 20 noticed all grades, from that which is so mild as to be difficult of diagnosis, to that which partakes of the true congestive nature, and kills within forty-eight hours. So far, we are satisfied that fully nine-tenths of those attacked are recently (within nine months) from a cold climate; a large number are recent emigrants, and a number are foreigners who have been living in the Northern or Western States, who have recently come to the city, and among these we notice by far the greatest mortality in proportion to the number attacked. The cause of this we leave for others to determine, though we are inclined to attribute it to the irregular habits of the individuals-they, by their own confessions, proving the irresistible impulse of every Western young man to " get on a spree" as soon as he lands at our wharves, and an attack of yellow fever based on intoxication is about as little amenable to treatment as a patient in the collapse stage of cholera. " One very important point we have noticed in connection with the yellow fever in existence here, is that quite a number of persons have been attacked by the disease within three to six days after their arrival in the city. This certainly tends to show that the existing fever cause, be it what it may, has acquired considerable potency. " It is not for us to speculate on the future; we have, as jour- nalists, to deal only with facts; so far, however, we think we may safely say that we will be spared a re-enactment of the scenes of 1853. For the week ending July 23d, 1853, the number of deaths by yellow fever alone was 429 ; while for the corresponding week of this year we have but 119. This difference may be in some degree the result of a deficiency of material, but it cannot be altogether so ; the fever-producer must be less powerful than it was then. "We have noticed a fact this season, which, although nothing new, is certainly very interesting. Several persons who passed safely through the epidemics of 1853 and 1854, and were then unac- climated, have had the disease severely within the past three weeks. One man is worthy of especial notice in this place. He acted as nurse in the hospital during the summers of 1853 and 1854, and passed unscathed; and this season the poor fellow died of black vomit on the fifth day of the disease." Yellow fever steadily increased until the week ending the 19th of August, during which week the number of deaths from this disease alone amounted to 394. From that time it declined in the 21 same regular order that it followed when on the increase: thus weekly, 357, 301, 255, 150, 89, which was the week ending Sep- tember 23d. As our Board of Health publishes only the weekly number of deaths, without giving the list of diseases, we are not able to make up any statistics from the general mortality of the city. All we can do in this way must be obtained from the records of the Charity Hospital. The following table will show the relative proportion of the different types of fever admitted into that Institution during this year. Table showing the number of Fever Cases of all kinds admitted monthly into the New Orleans Charity Hospital during the year 1855; also, the ad- missions for all diseases during the same period. 1855. FEVERS. January. February. March. April. May. June. July. August. September. October. November. December. 3 O Intermittent 162 145 101 137 153 215 176 128 180 305 290 238 2230 Remit, bilious 18 20 17 14 62 77 65 36 29 42 36 17 433 Continued 2 1 3 1 2 2 1 2 1 4 19 Typhoid 38 23 9 13 33 37 19 14 28 21 13 19 267 Typhus 10 7 6 3 5 6 3 1 1 1 1 44 Congestive ... 2 1 ... 2 5 Ephemeral 3 i i 1 1 1 • •• 3 11 Pernicious 4 2 3 2 5 4 2 1 7 i 31 Scarlet 5 i 1 2 ... ... 9 Chagres 1 ... i ... 1 3 Rheumatic 4 5 2 ... ... ... 11 Catarrhal 2 4 2 1 ... 1 1 11 Nervous 1 1 2 i ... 5 Puerperal 1 i 2 Hectic 2 ... 2 Yellow 1 34 586 1072 400 72 ii 5 2181 All fevers 251 208 144 177 260 377 857 1257 642 449 357 284 5264 All diseases 1208 744 766 743 957 1002 1370 1 1643 1085 699 862 843 12192 I Then, again, it will be seen that nearly half the cases admitted into the hospital this year were fevers, and of these, nearly half were intermittent. During the three months that yellow fever pre- vailed epidemically, there was one-fourth as many cases admitted of intermittent and remittent fevers. These facts, I think, tend to show the intimate relationship be- tween intermittent, remittent, and yellow fever, and more especially so when we see these different types intermingled or combined in the same subject, as we sometimes do. Thus, a person may be 22 attacked with intermittent and die with yellow fever, or be attacked with yellow fever, which will terminate as a plain intermittent. Dr. J. C. Nott, of Mobile, maintains that these fevers are entirely distinct diseases, originating from different causes. He admits that they may prevail at the same time and place, and even make a simultaneous attack on a person; but when this is the case, he says, the result is a "hybrid disease," partaking of the nature of both types, either of which may gain ascendence in the course of the attack. But to my mind, it is more rational to view them as varieties of disease, springing from a common remote cause, which may be modified by various attendant circumstances in the earth, air, and human constitution, and thus produce a corresponding variety of effects. I am sorry it is not in my power at present to discuss this question farther. The total mortality for the year in New Orleans was 10,096, of which there died of yellow fever 2,598. The epidemic ran its course, and ceased long before the appearance of frost, though sporadic cases continued to appear until late in December, as usual. The unquestionable domestic origin of this epidemic (no person pretending to trace it to a foreign source), together with the great expense and inconvenience of quarantine, caused the people to cry aloud for the repeal of the law at the next session of the Legislature, which met in January, 1856. A strong effort was made to accom- plish this, but it failed, and quarantine is still enforced at the station on the river, 70 miles below the city. The original opponents of quarantine are unwilling to have the law repealed too soon, prefer- ring, since so much money has been expended on the establishment, to have it kept up until all are convinced of its utter futility, at least as a protection against yellow fever. Perhaps when this result is brought about, the people may be willing to resort to more rational measures for getting clear of this pestilence. PATHOLOGY AND TREATMENT OF YELLOW FEVER. I know of no discovery made in the pathology of this disease in this city since my last report; but the January and April numbers of the Medico-Chirurgical Review contain a report on the yellow fever of Demarara, by Dr. Daniel Blair, Surgeon-General of British Guiana, which shows that some important discoveries have been made recently. I shall endeavor to test these discoveries as soon as opportunity offers. 23 In respect to treatment, I feel authorized to say, the general opinion of the profession in this region now is, that we have hitherto been giving too much medicine in yellow fever; in other words, we have been taking it out of the hands of nature, and trying too hard to cure it; whereas, all that seems necessary to be done is to assist nature in her conflict with the febrific cause. What this cause is we know not, but it is evidently something that seriously disturbs the most important vital functions of the system, and is very liable to cause death. In fatal cases, we generally observe before death an arrest or cessation of the functions performed by the great excretory or depurative organs, the liver, kidneys, and skin, also hemorrhages from various parts of the body, as the nose, gums, stomach, bowels, uterus, bladder, eyes, ears, scrotum, and any excoriated surface; likewise, serious disturbance of the brain and nervous system gene- rally. After death, we find the liver generally of the color of ground mustard, frequently dry, though sometimes engorged with blood, and generally displaying but little or no bile in the pori; we find the skin nearly always yellow; we find the stomach most generally containing effused blood, commonly called black vomit, the mucous membrane thickened and softened, occasionally abraded or broken, sometimes red and engorged with blood, sometimes pale and ane- mic; we find similar appearances in the mucous membrane of the intestinal canal; we seldom find much alteration of the kidneys ; we often find sanguineous engorgement of the brain and spinal marrow, with serous effusion under the arachnoid membrane; we sometimes find ecchymoses and gangrenous spots on the surface of the body and extremities ; and we frequently find the blood of nor- mal color, consistence, and coagulability, though the late researches of Dr. Blair demonstrate that very material alterations of the blood are often observed in the latter stages of yellow fever, and soon after death. Now, supposing a cadaver presenting most or all of these appear- ances were laid before an educated pathologist, without giving him any history of the case, or any clue whatever to the place of its oc- currence : would he be able therefrom to form a correct idea of the nature and symptoms attending the disease, or the length of time it had taken to cause the fatal result ? I am inclined to think he would not; and if so, does it not admonish us that we may have been accustomed to attach too much importance to post-mortem exa- minations, and to hope for more benefit from them than we had any right to expect ? In the dead body we see not the disease, but 24 merely its effects-its ravages on the human frame. Nor can we de- rive from this source alone, at least in the instance before us, any valuable suggestions in regard to its proper treatment, or the reme- dies that may be the most useful. We must study more carefully the nature of the disease during life, and the effect of remedies upon it. What remedy of generally admitted value, I would ask, have we been led to adopt by our discoveries in the dead-house ? Not one, that I know of I And now let us see what takes place in cases that progress favor- ably and terminate in recovery. The attack is marked by more or less chilliness, very soon fol- lowed by burning fever, with flushed face, injected eyes, severe pain in the head, back and limbs, and frequently nausea and vomit- ing. The head and stomach symptoms, when violent, are readily relieved by local depletion, the patient is easily thrown into copious perspiration by means of the mustard foot-bath and a cup of warm tea, and the bowels are readily evacuated by purgative medicines. If the patient now remains quietly in bed and avoids every kind of imprudence, the fever will run through its natural course in about three days; the functions of the great excretory organs, skin, liver, and kidneys, will be performed without interruption, and usu- ally, at the close of the third day of sickness the disease will come to a crisis and cease, leaving the patient very much prostrated. As the critical stage approaches, we frequently observe more or less hemorrhage from the nose, gums, or uterus. This is but a short description of an ordinary mild case of yellow fever, one that calls for very little medical aid. A majority of such cases would probably get well by the efforts of nature alone, if the patient would stay in bed four days covered with a blanket and drink some diaphoretic tea. But the picture will be quite different if the onus of disease should fall upon some particular part, or the function of any or all the excretory organs should be arrested. Then will arise a necessity for medical aid which must be promptly and skilfully applied, else death will be inevitable. But the question is, what constitutes the disease ? or what actually takes place in the system when a person is attacked with yellow fever, passes through all its stages and recovers ? This is a problem that has never yet been satisfactorily explained, yet we should not despair of accomplishing its solution at some time or other. Dr. Blair says, in the paper before alluded to, "that the test-tube and microscope are as necessary for the correct diagnosis 25 and prognosis of yellow fever, as the stethoscope and pleximeter for diseases of the chest." Yet the information to be obtained through these instruments is just beginning to be made known to the pro- fession at large. I am convinced that with proper means for investigation we may expect to obtain a great deal more knowledge of the nature and treatment of yellow fever by examining the blood and secretions during the life of the patient, than from the body after death. But I am compelled for want of time to dismiss the further consideration of the subject at present. The very best treatment for yellow fever is far from being agreed upon as yet; and the great diversity of practice that is pursued, in- dicates plainly that the disease is not yet well understood. As before remarked, the experience of the last two or three years, in this re- gion, seems to have led to the adoption of a milder course of practice than was formerly pursued; but the fell destroyer still claims its host of victims, in spite of potent drug or magic skill. We have as yet discovered no specific for yellow fever, and are left to treat it on general principles, aided by the lights of experience. In 1854, the discovery of a grand specific was publicly announced to the world by two of the physicians of Savannah, Georgia, Drs. Wild- man and Harris. This was the muriated tincture of iron, in doses of twenty to sixty drops every two hours. But, after a few short weeks of evanescent celebrity, its boldest advocate, Dr. Wildman, was swept off by the pestilence, and the remedy was soon consigned to the tomb of oblivion. I am by no means sure, however, that this stern decree was not both precipitate and unjust. From the highly laudatory accounts of the remedy that were published in the Savannah papers, and after being assured that the physicians who recommended it were respectable gentlemen, I was induced to give it a trial in our Charity Hospital. My first experiments were so satisfactory, that I not only continued its use there, but also in private practice, and with results much more satisfactory than I should have anticipated from the before-known action of the medicine, and the diseases and states of the system for which it had commonly been prescribed. The course I pursued was, first, to evacuate the bowels with castor oil, or some other mild purgative, and then commence with the tincture of iron, in doses of twenty drops, diluted with a little cold water, every two hours. Contrary to what I should have expected, the effect of the medicine was to gradually reduce the febrile excite- ment, and lessen the headache, to allay thirst, induce sleep, and cause a free secretion of urine. It sometimes constipated the 26 bowels, but this was easily obviated by mild purgatives. At other times it disagreed with the stomach, and had to be discontinued ; but, for the most part, the effects of the remedy were entirely satis- factory, and I think it deserves a farther trial by the profession. Drs. Harris and W ildman were induced to resort to this medicine as a remedy for yellow fever, by witnessing its beneficial effects in erysipelas and scarlatina, supposing there was some analogy in the three diseases. I will here close my remarks on the yellow fever of New Orleans during the last two years, regretting my inability, for want of leisure, to do anything like justice to the subject. I particularly regret not being able to discuss more fully the questions of the origin and in- fectiousness of the disease; but these questions are referred to in most of the contributions that are to follow, and the reader will have an opportunity to see what others think of them as well as myself. In the report of Dr. Barton, that comes next, will be found an investigation into the atmospheric and terrene conditions, accom- panying the origin and prevalence of both yellow fever and cholera, which is well worthy of perusal. It is not my business to pass judgment on the value of Dr. Barton's laborious researches into the causation of epidemics. I hope the reader will examine them care- fully, and award them the merit they deserve. Epidemic Cholera.-This disease has prevailed in New Orleans, and at several places in the interior, on different occasions during both of the last two years, but is evidently gradually disappearing. At this present writing (June, 1856), we have quite a prevalence of diarrhoea, some few cases, when neglected, running into distinct cholera, with cramps, and rice-water stools. I think it is the last expiring effort of the grand epidemic that broke out here in De- cember, 1848. We may now hope for a cessation of this epidemic during the next ten years. 27 APPENDIX. I.- Quarantine and yellow fever at Natchez during 1853-54 and '5b : the futility of the former and the local origin of the latter conclusively shown; and admitted for 1855, by the most strenuous advocates of the one, and the most ardent disbelievers of the other. By C. H. Stone, M. D., of Natchez.1 To begin with the year 1855. Quarantine was established on the 19th July, and the station fixed four miles below the city. The health of the people continued good, with the exception to be stated; no deaths from disease having occurred for four or five weeks. On the 4th September, the Board of Health published the follow- ing information for the people. "To the Board of Health. Gentlemen : I have the pleasure of reporting our city remark- ably healthy ; we have had no infectious diseases, and fewer cases of the bilious remittent and intermittent fevers than I have ever known. There is no sickness at the quarantine station; I think the indications are clear that we shall have a very healthy season. Yours, respectfully, L. P. BLACKBURN." Natchez, September 3d, 1855. 1 This paper is taken from the New Orleans Medical News and Hospital Gazette, for Nov. 1855, and contains the substance of a communication to me which was in- tended for the report I expected to make last year. Dr. Stone is one of the most respectale physicians in the south, and his statements are entitled to all confidence. He demonstrates the local origin of yellow fever in Natchez as plainly as Dr. Barton and I have down in New Orleans ; he also shows how little benefit has been derived from quarantine; but he omits to notice the spread of the disease in the country back of Natchez, within the last two or three years, so much like measles, scar- latina, and hooping-cough. Dr. Stone's paper is a valuable one. E. D. F. 28 On the 6th September, the following card, dated the 5th, was published. " The undersigned, practising physicians of Natchez, deem it their duty to state, that within a few weeks, several cases of yellow fever have occurred in this city; some of which have recovered, others have died, and at this time, there are other cases existing. W. HARPER, W. L. JONES, C. H. STONE, JNO. C. INGE, H. LYLE." On the 8th September, the Board of Health met, and the following was the result of their labors. City Hall, September 8th, 1855. " At a called meeting of the Board of Health, held this day at 3 o'clock, P. M.: Present, R. W. Wood, Esq., Mayor; Dr. L. P. Blackburn, Health Officer; Messrs. Burns and Doniphan The following report of Dr. Blackburn was submitted, which, on motion of Mr. Doniphan, was adopted. "To the Board of Health of the City of Natchez. Gentlemen :-It becomes my painful duty to announce to you the existence o/yellow fever in our city. Yours respectfully, L. P. BLACKBURN, Health Officer." The following preamble and resolution of Mr. Doniphan was, on motion of Dr. Blackburn, unanimously adopted :- " The City Council, with commendable diligence, as soon as yellow fever was announced in New Orleans, established, and have con- tinued to enforce rigidly, the quarantine laws against all boats and their passengers from infected ports, and have also had an armed guard on the roads leading to the city, as well as a secret police officer to detect infractions of the law, and have done everything in their power to keep Natchez free from exotic yellow fever; not- withstanding all which it is in our midst, and threatens to become epidemic: " Therefore Resolved, That the yellow fever now existing among us, is a visitation of an all-wise Providence, against which the most 29 j udicious human efforts have been unavailing, and while we deplore the fact, we feel it our duty to make it known to our citizens, that they may take such measures to avoid the infected atmosphere as they may deem advisable. " Resolved, That the proceedings of this Board be published in handbill form, and posted on the streets, and also inserted in the papers on Tuesday. On motion, the Board then adjourned. W. H. STEWARD, Secretary of the Board of Healths Now for the origin of this yellow fever:-■ First Locality.-The first cases that came under my notice, were in the family of Mr. J. D. Shields-his wife, four children, and five servants, and the first no doubt in the city, as follows: August 17th, Bayard Shields, aged 6 years; 17th, Charles, servant, aged 8 years; 19th, Mary, servant, aged 11 years; 19th, Joe, servant, aged 50 years; 20th, Mrs. Shields; 20th, Dunbar Shields, aged 13 years; 21st, Barthena, servant, aged 14 years; 21st, Abijah Shields, aged 2 years; and on the 22d, Sye, servant, aged 25 years. Before these cases occurred, I had once visited Wintz, a servant, 35 years, on the 8th August, then sick one or two days. She had had yellow fever in 1853, and I saw nothing peculiar in her attack this year. On the 12th August, Judy, 8 years, was taken sick, and on the 14th, Mary, 40 years, servant. I did not see these cases, but Mrs. Shields, who has had much experience in southern fevers, assures me that the attacks of Wintz and Mary were exactly like each other, and different from all the rest; and that Judy's was as much unlike these, as precisely similar to Bayard's and the others. The reason for thus stating these three cases, will be apparent in the sequel. Up to the 15th October, these persons have remained free from diseases. It is well to state here, that Mrs. Dr. Chamberlain, and Mrs. Gab. B. Shields, both living in the country, had attacks of yellow fever after visiting Mrs. Shields' residence; the former remaining there 36 hours, and the latter being there several times. On the 22d August, a case occurred at Mr. J. Bradley's, adjoining Mr. Shields. On the 23d August, Mr. Skinner, and on the 26th, Mr. Knicker- bocker (both residing at Mr. Walworth's, also adjoining Mr. Shields), and on the 26th, Mr. Walworth's servant, Mark, had attacks. Mr. 30 Walworth's family were absent, and his servants, excepting Mark and one other, were protected persons. The residences of Shields, Bradley, and Walworth, are on a high, dry, and clear ridge, one-third of a mile northeast from Main Street, or the centre of the city, and are the only ones on twenty or more acres of land. Second Locality.-On the 19th August, occurred the case of Ken- nedy, an Irishman, laboring in a brick-yard, one third of a mile southwest from the city, and living in the Lancaster Row, on the second square southwest from the centre of the city, and one-third of a mile from the first locality. On the 25th, Kennedy's mother, living in the same house, was attacked. Third Locality.-The first case under Dr. Harper was on the 20th August-Greeincher, near the Cotton-press, and near the river, and one mile north from the centre of the city, and half a mile north from the first locality. Fourth Locality.-The first cases under Dr. Lyle, were on the 21st August-George, a young man, living with Crone and Swarty, on Main Street, in the centre of the city; on the 24th August, Mrs. Staniforth, living three squares east from Main Street, and centre of the city; on 27th August, Boas and his wife, living one square from Main Street, quarter of a mile southwest from centre of the city, and within two squares of Kennedy's, or the second locality, one-third of a mile from the first locality, also, a third of a mile from Mrs. Staniforth's, and one mile from the third locality. No doubt, other cases occurred at or near these dates, and at other points of the city, I mention but one very probable one. It was called, before death, by Dr. Davis, "Typhus Stupidus," and was reported in the papers as dead on 31st August, of "Typhus"- " Stupidus" being left off, and Icterodes not being added. The cases under Drs. Harper, Lyle, and myself had no commu- nication with each other-with steamers or with goods, wares, or merchandise from infected districts, of which there was but one in the South at the time. But those at Mr. Shields', and the outbreak of the disease in the city, have been attributed by some to one change of clothing worn by Mr. S., while remaining forty-eight hours between the 30th July and 1st August, on the wharf-boat at the quarantine station, where, at that time and before, there had not been a single case of the disease!!! Let me see. Wintz took the soiled clothing from Mr. Shields' 31 carpet bag, threw them in. the sun, and they remained exposed in the open air all night. Mary washed them the next day, August 2d. Wintz, who had had yellow fever in 1853 was side on the 8th. Judy, who had not touched the clothes, on the 12th, and Mary on the 14th. If Wintz and Mary, or Mary only, alone received the yellow fever from these clothes from touching them, so did Judy without doing so, and Mr. Shields should have been the first case. Whether Mr. Shields had any attack I am not disposed to assert or deny. He was suffering on the 21st and 22d August, in the manner that Dr. Lewis, of Mobile, describes as sometimes happen- ing, and very much as Mr. Elliot, whose case is to be mentioned as one of Mr. Pearsall's attendants, and moreover, he has remained free from attack to the present writing, 15th October. If Wintz had a second attack, Mary, far more probably, had a first one. If Wintz and Mary had yellow fever, Judy, most certainly, had the same, which fixes the dates of the first cases, on the 6th or 7th of August for Wintz-on 12th for Judy; and on the 14th for Mary. But it is of small moment about these cases and dates. The disease was in Mr. Shields' family most clearly on the 17th August, and the question is, was the poison or contagion of yellow fever conveyed to his house in a two foot carpet bag, containing one change of soiled clothes, and a few clean ones; and again, how did this virulent contagion get into the carpet bag ? As many people believe in this power of yellow fever contagion, now that their fear of the disease has been wrought to such tension, I propose to show that the thing is simply impossible. The evidence given must dis- pel any such idea from the minds of all, here or elsewhere. The yellow fever was said to have been introduced into the Island of Boa Vista, one of the Cape de Verdes, by the British Steamship Eclair in 1845. Dr. McWilliam was directed to inquire into it, and in his report makes the following statement: Twelve bags of soiled clothing were landed on the 21st August, and dis- tributed to seventeen washerwomen on the next day. The testi- mony respecting the periods of attack of thirteen of them, was taken in April 1846, four having died, but of what disease or when taken sick, nothing is said. The names are omitted here, though given in the report. No. 1. Had fever late in December. No. 2. Had fever late in January. No. 3. Was sick after No. 1. 32 No. 4. Had fever in January, her mother, father, and two bro- thers were taken first. No. 5. Not sick until lately (near April, 1846). No. 6. Never had fever. No. 7. Taken about 20th October. No. 8. Does not know the exact time, but not till Mary had died. No. 9. Had not the fever until after her husband, who was at- tacked after the fever became general. No. 10. Never had the fever. No. 11. Had fever about the same time with the rest of the family. No. 12. Had fever after her brother, who died some time in No- vember. No. 13. Was never attacked till January. If such be the result, actually nothing, from washing, what may be reasonably calculated for seventeen women at a thousand, not to say one thousand seven hundred pieces, and these, from a ship in the tropics reeking with African yellow fever; how much New Orleans yellow fever ought to have been carried into the city of Natchez by one change in a two foot carpet bag, which remained two days on a wharf-boat at the Natchez quarantine station, where there had not been one case of that disease ? Certainly, less than none! But, perhaps, by certain shakes, up, down, horizontal, the potency of nothing was exalted to the thirtieth degree, and the spiritualized attenuation received in infinitesimal doses sufficed to do the deed. An example of much from nothing, in which some people are found to believe. I hope my friend Mr. Shields, will in future shake his bag less potently, or perhaps better reverse his shakes. 1853. It has been said that the epidemic of 1853 was owing to the introduction of the case of Mr. Pearsall, who came from New Orleans ill of the disease, and died at the Mansion House, on the 17th July. Dr. Blackburn and Dr. Davis make this statement, and I offer the following proof that it is not true; nor is it true that Murray, who came home on the day of quarantine being established, ill of the disease, and died on the 26th July, caused the epidemic. The first cases of that year, were as follows:- The first on the 14th July, a foreigner, who arrived in New Orleans on the 13th or 14th of June, where he remained four or five days, and reached this place on the 20th. He either contracted 33 the disease here, or his case shows a period of incubation of twenty- six days. The second on the 15th; third on 26th; fourth on 25th; fifth on 27th; sixth, Larry Curtiss, on 31st July or 1st August, a barkeeper in Mansion House, and one of Pearsall's visitors; the seventh on 2d August, whose arrival, stay and departure from New Orleans, and arrival here, were the same as the first case. The periods of incu- bation for her, will be forty-three days, or she received the disease here. These cases, except the first and seventh, were far removed from each other, and all except Curtiss, were on different squares from the Mansion House. A man, I believe a barkeeper, died at the Mansion on the 2d of August, from falling over the banisters while in delirium from drink. Dr. Lyle states, that his first case was on the 16th July, and from the 17th, " almost every case assumed that form." I give the following account of the attendants and visitors of Mr. Pearsall, which I have every reason to believe constitutes the whole truth. Mr. Hugh Elliot was more constantly with him than any other person, Gus excepted. About the middle of August (about twenty- eight days from the 17th July), Mr. E. was confined to his bed for four or five hours, felt badly for three or four days after, and has had no other sickness since, though exposed during the remainder of that and to the 15th October of this year. The disease was very generally prevailing before his attack. Gus belongs to Capt. Knight, who says that he has never had yellow fever. There were two barbers to shave him, but of these I can learn nothing, as they are not in the city. Mr. J. R. Mitchell did not have yellow fever till 1854, and then in New Orleans. Larry Curtiss, who Mr. Elliot shows was in the room at the seal- ing of the coffin, but does not remember to have been there at other times, was attacked on July 31st or August 1st. Dr. L. P. Blackburn was his attending physician, and does not admit that he has ever had yellow fever. I have been unable to learn that other persons were in his room, except Dr. Lyle. If the preceding evidence be not sufficient to show that Pearsall's 34 case had no agency in the production of the epidemic, of which cases began before his, I am thrown under the necessity of denying almost that we had any epidemic at all; certainly not till thirty or forty days after his death, and then to have begun in the usual mode: cases here and there become more and more numerous till prevailing generally. This has usually taken several weeks, and would carry us into the middle or last week of October. At this date, the epidemic of 1855 is nearly at an end, perhaps only for want of subjects. And I prove this position in this wise. After the announcement by the city authorities as advised by me, then health officer, that an epidemic was impending over us (for which I was bitterly abused for a week), Dr. Blackburn for about two weeks, and Dr. Davis for three or four days, denied that there was any yellow fever in the city; forty days (quarantine number), at least having elapsed since Pearsall's case according to the former, and thirty or more days according to the latter authority, and no disease resulting till the middle of October-that is, provided these two authorities were not mistaken in 1853, as they were in 1848 and in 1855. I think it more than the people care to believe, or have bargained for, that one or two cases can cause an epidemic thirty or forty days after introduction. This is like running ahead of the fox. In 1854, Dr. Blackburn being health officer, quarantine was established on the 25th August, long after yellow fever was known to exist in New Orleans. It was discontinued on the 21st October, while the disease was still in New Orleans, and goods in that city of necessity more imbued with the poison or contagion, and while he disease was known to be in Vicksburg in an increasing degree, and springing up in various parts of the South. This statement shows the supreme absurdity of that quarantine. Cases of yellow fever occurred in my practice between the 12th and 26th August, and between the 9th and 15th October. Dr. Lyle had cases under his care, and Dr. C. L. Smith had one case. These, in all, about fifteen, were of local origin. Dr. Holcombe may have contracted the disease in Natchez, or at Lambdin's, six miles below the city, in Louisiana, where it was said that yellow fever pre- vailed, but denied by some, for the very insufficient reason of its mildness. That his case was yellow fever, was the opinion of Drs. Lyle, Davis, Fortu, and the writer. It was called dengue by one physi- cian, and all were denied by Dr. Blackburn to be yellow fever. 35 Besides these cases, one was introduced which calls for all the at- tention of the people. It is the case of Mr. Poque, a Kentucky trader, who contracted the disease, most probably elsewhere, and was treated by Dr. Blackburn in this city. That Poque had yellow fever, is susceptible of full proof. If Pearsall's case gave an epidemic in 1853, why did not Poque's in 1854? I have a few words to say respecting errors promulgated with great zeal, about the disease and quarantine during years preceding these three. Judge Dubuisson, July, 1845, teaches the Mayor and Selectmen, and the pupils of the Institute, that "the quarantine has been imposed seven times, to wit: in 1841, 1842, 1843, 1817, 1848, 1853, and 1854, with complete success, except in 1853." Drs. Cartwright, McPheeters, Lyle, Jones, Cochran, and Thistle, authorized me to publish in the New Orleans Medical and Surgical Journal for 1848, that several cases of yellow fever occurred here during 1847. There were at least fifty or sixty cases, and among them some of the most intense I have ever seen. Perhaps those physicians knew more about yellow fever than Judge Dubuisson, though perhaps the Judge does not think so. Respecting 1848, Judge Dubuisson and other medical men, and Drs. Blackburn and Davis, denied that the epidemic of that year was yellow fever. They called it dengue. Yet Judge D. admitted to me, in 1854, that he had an attack of yellow fever that year in the city. Dr. Blackburn, also, had an attack of yellow fever that year. He was attending Mr. Van Horen, who had black vomit within a few hours after. Dr. Jones and I became his physicians, which took place because Dr. Blackburn was attacked at this time. It was this attack of yellow fever that gave Dr. Blackburn his pro- tection against the contagion of Pearsall's case, and against the "morbid miasm" from the "three" who died, and the "four" who "recovered at the quarantine station" in 1854, and against the "mor- bid miasms" of the hundreds he has attended since 1848, and against the poison of yellow fever, generated in the city of Natchez several times since. Few people now deny that the so-called dengue of 1848 was yellow fever. There were about forty deaths, with hemorrhages, etc. Within ten years we have had three epidemics, and during two years only, we have not had some cases according to my observa- tion. 36 Dr. Lyle has been here twenty years, and says that during that time, he has seldom failed to see some cases every year. Cases of yellow fever occurred in 1854, as in 1848, and in 1853, and perhaps in other years before quarantine was established. Therefore, it is neither to the discredit nor credit of quarantine, that epidemics have or have not happened during those years. But this was not the case in 1855. Fortunately, the quarantine was established (and was rigidly enforced throughout) several weeks before any case of this disease took place-nearly fifty days up to the time when the Board of Health, as advised by Dr. B., admitted that yellow fever existed in the city. The explanation given of all this, and the reason why Poque did not cause an epidemic in 1854 is, "that an all-wise Providence did not intend us to have an epidemic that year, but did intend it in 1853 as in 1855." An all-wise Providence no more regards quarantines against the indigenous, domestic, local, in a word, against the en- demic diseases of a country, than other vain efforts of vain and self sufficient man. The Board of Health deserves much credit for the graceful and prompt manner in which they admit that in the con- test waged with Providence, they have been conquered; and more for the admission, so forcibly implied, that in 1854 there could have been no contest with Providence-in other words, that " Provi- dence did not intend an epidemic that year"-only fifteen or sixteen cases of local origin, and one or two imported-otherwise, the Board of Health would have come out of the contest, then as now, second best-a conclusion which the Board will admit, no doubt. Yellow fever is going through one of its grand cycles of increase in violence and of extent of territory invaded. It is to be feared that we have not seen the end of it yet. The disease has already appeared in Baltimore in 1853 and 1854 (there also in 1849); in Philadelphia in 1853; in St. Louis in 1854; in Norfolk, Portsmouth, Gosport and Memphis in 1855. It will soon be shown that it was of land origin in Gosport, as in all the other places named. Another cycle began in 1791-3, prevailing more extensively than usual in the West Indies and Spain, and for many years, through the Northern Atlantic States. Its local origin was well shown in six different places during the embargo, and over and over again when quarantines were established. Another cycle again may be stated in 1817-22, during which time, the disease appeared in a great many places, as Philadelphia, 37 New York, and at Natchez for the first time, epidemically at least, and in numerous other places in the United States. This periodical increase of the disease in extent of country it invades, is the explanation of its communicability by persons, goods, carpet bags, etc., so apparent to many, and yet so unreal. The poison of yellow fever may be put up or generated in the holds of ships, and thus it may be, and often has been transported from port to port, or comes from the open ocean into healthy ports, giving the disease to those who go on board, or near the ship after opening the hatches. Infected ships have long since been known to be " floating places of infection." Let them be quarantined, and avoided by the unprotected. Let river steamers go with wind sails and open hatches, and then fear not to enter the hold, even if they started full of an infected atmosphere. It cannot remain against a ten knot breeze. Thus far, quarantine and no further-for belief in all else is un- founded-mere post hoc conclusions, and leads to panics, inhumanity, and back to ages of barbarism, and sadly increases the mortality from the disease. II.-On the Yellow Fever of Woodville, and its vicinity, in the State of Mississippi. By Alfred C. Holt, M. D. [The letter of Dr. A. C. Holt, on the yellow fever of Woodville, Mississippi, and the region around, shows the author to be a man of accurate observation and reflection. He stands deservedly high as a practitioner, and does an extensive business. He here gives us a valuable collection of facts relative to the origin and extension of yellow fever, and declares his conviction that under favorable cir- cumstances^ this disease may be transported from one place to another, regenerate itself, like scarlatina and measles, and be communicated from person to person. For myself, I am free to confess that the facts presented by Dr. Holt, together with many others of the same kind that have come to my knowledge within the last three years, in this region, appear to me strongly to support this position. In maintaining the opinion that yellow fever is transportable and com- municable under favorable circumstances, Dr. Holt says: "It does not follow that it may not be of domestic origin whenever causes exist favorable to its production." This is a point of equal, if not greater importance than the infectiousness of the disease; for we may pos- sibly discover the means of preventing the production of yellow fever, but if the disease be transportable and communicable, the 38 only hope of confining it within bounds must rest on the complete cessation of all intercommunication during the season of its prevalence. Fortunately for mankind, this is not a common, but an extraordi- nary feature of the disease, which but rarely occurs. Why it should present itself only in some seasons and localities, and not always, forms an interesting problem, as I have before remarked. It will be seen that two others of my correspondents, Drs. Wood and Stone, present some strong proofs of the local origin and non-conta- giousness of yellow fever. Dr. Holt points out what he considers to be well marked dis- tinguishing features between yellow fever and dengue. He looks upon them as " distinct diseases," yet he says there is " a striking resemblance between them," and even admits that " they probably originate from similar causes, but there is wanting some ingredient to make them identical." In support of his position, he refers to the analogy afforded by chemical isomerism, where the same ele- ments, combined in the same proportions, produce substances alto- gether different. This is the very analogy reverted to by me about nine years ago in support of the opposite conclusion. I do not con- tend that bilious fever, dengue and yellow fever are identically the same, but that they are varieties of disease springing from the same elements differently combined and modified by attending circum- stances. They all prevail at the same time and place, and their diagnosis has puzzled the most accurate observers. One thing is certain-that whenever dengue prevails epidemically, the few fever cases that terminate fatally always present the commonly admitted signs and appearances of yellow fever, such as black vomit, yellow- ness, etc. In this assertion I have been fully supported by Dr. C. H. Stone, of Natchez, and Dr. G. A. Ketchum, of Mobile.-E. D. F.] Woodville, March. 6th, 1856. Dr. E. D. Fenner- Dear Sir : At your request, I give you a brief account of yellow fever, as it prevailed in this region during the last two or three years, and particularly as to " the facts tending to throw light upon the question of its origin, whether foreign or domestic." The first case of which we have knowledge in 1853, occurred at the Woodville Factory, which is situated about a mile south of Woodville, in a beach grove and in a locality considered healthy. This case was a man named Lee, who had been one of the factory operatives. He left the factory late in July, and visited New 39 Orleans; returning directly thence, he reached the factory on Wed- nesday, the 9th August, and died with black vomit the following Sunday night, '3 -- Though he had a chill soon after his arrival at the factory, Wed- nesday evening, yet he left his bed the next morning and walked into Woodville, where he remained several hours. On the 25th of August, the next case occurred at the factory; on the 28th, 29th and 30th, several others were attacked, and during the first week of September, the disease became general among the factory hands. I could trace no chain from case to case-nearly all of them had been in deceased's room during his illness, and at the time of his death. As a rule, the attacks did not set in with violence-those in which this was the case, generally yielded readily to treatment, while many of the most formidable cases I encountered commenced with seeming mildness, and were attended throughout with little suffering. The deaths ordinarily occurred on the fifth and seventh days; in fatal cases, delirium, hemorrhages, jaundice and black vomit were common. On the 26th of August, Alfred, a boy belonging to Dr. Hender- son, was taken; on the 31st Dr. H. was attacked, and during the next ten days his whole household, numbering nine persons, passed through attacks. On the - of August, Major Feltus was taken ill. His attack, at the time, was not considered yellow fever, but subse- quent events satisfied his physician, Dr. Angell, that it was so. As soon as he was able to be removed, he was taken to the country with his family, where one of his children had an attack soon after. In the cases of Maj. F. and Dr. H.'s boy Alfred, there had been no communication with the factory. Dr. H. had been in attendance on some of the earliest cases at that place. The residences of both these gentlemen are on the southern boundary of Woodville, and therefore nearest the factory. On the 7th of September, I visited two children at Mr. Noble's, about two hundred and fifty yards north of Dr. H.'s. These proved to be cases of yellow fever, and I am satisfied had had no commu- nication with any other cases. From this time until the 21st, occa- sional cases occurred having no traceable connection with each other, at which date cases were numerous, and in various parts of the village. When the first death after Lee's occurred at the fac- tory, many of the citizens of Woodville becoming alarmed, left town, leaving something over two hundred unacclimated subjects, 40 not more than six or eight of whom escaped attacks. As many in- stances in which the fever occurred in families in the surrounding country contain points of interest, I will detail a few, and in order to explain fully the origin of the disease in the family of Mrs. McCausland, I give you some extracts from a letter of Mr. J. Scott Smith, of West Feliciana, written while the events were all fresh in his memory. The letter reads as follows:- "Early in September, '53, my nephew, William McDermott, a youth about eighteen years old, arrived at my mother's house from Arkansas, having landed on his way down at Vicksburg, where he spent one night, the yellow fever prevailing at that place at the time. " lie came thence to Bayou Sara on a boat on which there had been cases, and some deaths from yellow fever-remained one night in Bayou Sara, the yellow fever prevailing there also, and the next day reached our house, ten miles in the country, with fever on him. He died five days after, throwing up a large quantity of black vomit before death ensued. " In a few days Miss W., an inmate of the family, was taken sick, and about the third day of her illness Mrs. McCausland visited my mother, and was in Miss W.'s room two or three times during the day." Mr. S.'s letter, in continuation, describes the cases of several other members of his mother's family, and the death of his brother Mr. P. C. Smith, with black vomit-all having been exposed to the case of young McDermott, and having had no other exposure. The cases occurred in rapid succession, and were all pronounced by the attending physicians to be yellow fever. Mrs. McCausland, who resided nine miles from Woodville, visited (as is stated by Mr. S.) his mother's during the illness of Miss W., "and was in her room two or three times during the day." This visit was on the 20th of September; on the 26th Mrs. McC. sickened and subsequently died. On the 1st of October, owing to the prevalence of the epidemic in Woodville at the time, I did not see her, though her usual medical attendant-one of the gentlemen who attended her-pronounced her case to be yellow fever, and sent me for examination a vial of fluid ejected from her stomach previous to death, which was unquestionably black vomit. Twenty days after the death of Mrs. McC., I was called to attend her daughter, Miss Eliza, who died on the tenth day after a well marked attack of yellow fever. During the progress of her case, 41 three servants who had aided in nursing her mother, were taken- on the day of her death, her brother Marcus was attacked-the day following, her sister, Mrs. Chinn, and a few days after Mrs. Stanton (who had assisted in nursing Mrs. McC. and Miss E.) had a well marked attack. During the same fall, yellow fever macle its appearance on the plantation of Mr. McCaleb, in West Feliciana Parish. As this place adjoined one owned by myself, I was, of course, particularly interested, and thus became fully informed of the facts. Dr. Wm. Stockbridge, who boarded in the family of Mr. McCaleb, was in- duced to go into Bayou Sara during the prevalence of the epidemic in order to render his aid to the physicians of that place, several of whom were prostrated at the time. Soon after his return to Mr. McC.'s he sickened, and in a few days was numbered with the dead, thus falling a victim to the generous impulses of a heart which had been ever prompt to respond to the calls of the sufferers. In quick succession, nearly all the members of Mr. McC.'s family, white and black, were attacked, himself and two of his children soon following Dr. S. to the grave. In my quarter, which was not over half a mile from Mr. McC.'s residence, no cases occurred, nor were there any elsewhere in the neighborhood. Dr. J. W. Davis, who resided nine miles from Woodville, visited a family near Fort Adams, in which there has been several deaths from yellow fever, and during the illness of one of its members. Twro or three weeks after, he died with black vomit. It cannot be ascertained that he was exposed to yellow fever except during this visit. Dr. B. Baldwin visited Dr. Davis several times in the latter days of his illness, and, twenty-two days after his death, sickened and died in five days with black vomit. Dr. Baldwin had been in at- tendance on Mrs. McCausland six weeks previous to his attack- this and the case of Dr. Davis were his only exposures. Yellow fever prevailed in 1853 in many other families in the adjacent country, but I have confined myself to those instances in which little or no doubt existed as to the first exposure. In 1854 we had no yellow fever in Woodville, or the surround- ing country. I treated ten or twelve cases of dengue during the fall. I am aware that many gentlemen whose observation and experi- ence entitle their opinions to respect, entertain the view that yellow fever and dengue are so closely allied as to be one and the same; 42 and while it must be admitted that the resemblance is very strik- ing, my own observation leads me to the conclusion, that they are distinct diseases-originating probably from similar causes, yet wanting in some ingredient to render them identical; and when we call to mind the isomeric theory in chemistry, and the fact that under this law the same elements in the same proportions even, produce entirely different results, it is not difficult to believe that a similar law may prevail in the causes originating diseases. The assertion that dengue is a mild form of yellow fever, it is clear to me, cannot be true-for, during an epidemic in Woodville in 1850, in which nearly every soul suffered an attack, and from which not a death occurred, there were a larger proportion of ap- parently very severe cases, than would be presented in the same number of yellow fever cases. I can in my own person bear wit- ness that there is nothing mild in an attack of dengue, either in the actual suffering and distress, or the condition in which the system is left by an attack. If asked to state the difference between the two in symptoms, I would say that in dengue the pains are more severe, longer continued, and more erratic; the rigors continue longer, often lasting for two or three days when the covering is moved ; while in yellow fever they rarely continue over an hour or two; the occurrence of an eruption in the majority of cases of dengue resembling measles, and often that of urticaria; the pain- fully disagreeable visions and illusions which haunt the mind in dengue, often even in waking moments, and invariably in slumber; the injurious and sometimes fatal results of what are called "im- prudences" in yellow fever-the harmlessness of the same acts in dengue; and in cases of severity, the greater tardiness in dengue in an entire return to healthful feeling. The debility is as great in the one as the other-probably in yellow fever oftentimes greater-but when the convalescent who has "got well through" an attack of yellow fever is once upon his feet, as a rule, his sensations are all joyous; he feels as if he had a new lease of life, and this not merely from a sense of danger escaped-while one just out of a severe at- tack of dengue, if asked how he feels, the most usual and very expressive reply is, "I feel mean;" he rarely enjoys those delightful emotions which an entire return to healthful feeling can alone im- part, but for days, and weeks, and sometimes months, he feels " mean." In dengue there is also a marked perversion of the sense of taste-nothing is natural, and the patient, in early convalescence, will turn with loathing from the idea of eating the most delicate 43 dishes. While it is undeniably true that rare cases of a second attack of yellow fever do occur, I am persuaded their apparent frequency arises from the fact that dengue is often called yellow fever, and vice versa. The mistake is an excusable one, in view of the many points of resemblance between the two diseases. During the epidemic yellow fever through which we have just passed, I treated seven cases which I pronounced dengue, though nurses and patients were disposed to call them all yellow fever. In September, 1855, yellow fever again made its appearance in Woodville. The circumstances attending its commencement and progress are as follows:- John Blacker, from Cincinnati, reached Woodville on the 15th August, having landed on his way down to Vicksburg, where he remained a few days. As yellow fever then prevailed at that place, and Woodville was under quarantine regulations, he was sent, on the 27th, to Hastings House, a temporary station one mile and a half southwest of Woodville, at which place he died with yellow fever on the 2d September. It is believed the disease had developed itself before he left town, as he had a chill on the even- ing of the 26th. On the 28th, Mrs. Blacker and daughter, Mrs. Craige and children, and Mrs. Brown, all residents of Woodville, and friends and relatives of Blacker, visited him at Hastings. On the 5th September, Mrs. Craige was taken sick, her attack being very slight. She was not visited by any physician, and we have only the opinion of her neighbors, who were familiar with yellow fever, and who pronounced hers a case of this disease. On the morning of the 6th, I was called to see Miss Woodbridge. On the night of the 6th, a negress of Bengoner's had a slight chill followed by a fever of five or six days' duration. This was her own state- ment to me when called to prescribe for her on the 12th. She ejected black vomit the next morning and died on the 14th. On the morning of the 7th I prescribed for Wm. Beach, in the same house with Miss Woodbridge; on the morning of the 8th for Mrs. Blacker and her daughter, both of whom were taken during the night of the 7th; on the 9th for two children of Mrs. Craige; on the 11th for Anderson, a negro boy at Mr. Butterworth's; on the 13th for Mrs. Brown ; on the 18th for Henry Blacker, and on the 21st the disease was declared epidemic. All the above mentioned cases (Mrs. Brown, H. Blacker, Ben- goner's negress, and the boy Anderson excepted), were slight at- tacks, and in consequence of the short duration of the febrile action, 44 I could not pronounce them at the time cases of yellow fever; but all doubts in relation to the majority of them were removed by subsequent symptoms during and after convalescence. I have not been able to discover that Miss W., Wm. Beach, Ben- goner's negress, or Anderson, had any communication with John Blacker, unless the fact that they resided upon the street along which Blacker passed on his way to Hastings', can be deemed such. Blacker and Craige reside in the northeastern portion of the vil- lage, Butterworth in the southwestern, about half a mile apart. Mr. Beach's and Bengoner's houses are on an air line between the two-are one-third the distance from Blacker's to Butterworth's; Hastings is half a mile beyond Butterworth's, on the same road. Mrs. H. D. Smith's plantation is one mile beyond Hastings, and two miles and a half southwest of Woodville. About the 1st Septem- ber, Jacob, a negro on Mrs. Smith's plantation, was taken sick. His attack being slight he had no physician, though it excited no suspicion as to the nature of it. On the 16th or 17th I was sent for to prescribe for Hannah, the wife of Jacob. On the following day I found twelve or fifteen additional cases in the hospital, which, after careful examination, I pronounced yellow fever. The first cases after Jacob, were members of his family. In the next twenty- four hours I had sixty cases under treatment, and the disease ran rapidly through the family, white and black. Jacob was, without doubt, the first case on the place. He had been passing frequently back and forth near Hastings, during the illness of John Blacker, and a few days before his illness opened a bale of India bagging just from New Orleans. This was his only known exposure to yellow fever, if such it may be called. On the 26th August I was called up before day by Mr. Wall, returning from Cooper's Well, on board the steamer Princess, and found him to be in what proved to be the chill of a yellow fever attack. We landed in a few hours at Tunica, and he was conveyed to his father-in-law's, Mr. F. A. Evans, fourteen miles from the river, where he had a severe attack of nine days' duration. Upon reaching Mr. E.'s I sent for acclimated nurses to aid me, notwith- standing which precaution, in the succeeding ten days or two weeks after Mr. W.'s recovery, fourteen negroes, constituting all the household servants, stable-boys and hostlers, were attacked, and some three weeks after the last case in the yard, the disease de- veloped itself in the quarter, which is half a mile from the resi- dence. The plantation of Mr. Evans is in a healthy locality, isolated 45 by fields and forests, and in a region where yellow fever never be- fore prevailed. A few weeks after Mr. Wall's recovery, he visited the plantation occupied jointly by himself and his nephew, Mr. Williams, near Fort Adams, accompanied by Mrs. W. and her servant, who had also recently recovered from yellow fever. Six days after their arrival, the woman in whose room the servant of Mrs. W. had been lodged, was taken ill, and on the third day of her attack Mr. W. communicated his suspicions to Mr. Williams, that it was a case of yellow fever. Mr. Williams immediately left the place and proceeded to Dr. Sheppard's, in Pinckneyville, was taken ill the following night, and had a well-marked attack of yel- low fever. Before he was up from his bed, two servants of Dr. S. were attacked. Dr. S. and his wife had both had the yellow fever in 1853. In the mean time Mr. Wall had separated the negroes on the plantation, selecting some five or six who were known to have been in the room with the first case, and keeping them apart from the others, and in this manner the progress of the disease was arrested. It seems to me a fair inference that if the fever had originated on the place, this separation would have been of no avail-but Mr. W. was able to designate which would be liable, and the result proved the correctness of his action. Your question: "Do you believe yellow fever transportable and communicable? and if so, give the grounds of your belief," is sufficiently answered in the foregoing sketch. Except upon the hypothesis that yellow fever can re-create itself, under favorable circumstances, I see no satisfactory explanation for the cases I have quoted, and going over the whole country during the last three years, such instances might be added almost ad infinitum. It is no argument against this belief to state the fact, that the disease does not invariably spread from an imported case. We all know and admit this to be true-and we also know it to be true, that a well-marked case of scarlatina can occur in a family, and not another case follow, or that every member of a household may pass through this disease, and none others in the immediate neighbor- hood suffer. And yet, no one will deny scarlatina to be highly contagious and infectious. The first case in Woodville, in 1854, was Mr. Thurber, a gentleman just from Galveston, where yellow fever was prevailing, who fell sick soon after his arrival at Wood- 46 ville; and the next cases were in the family in which he was sick, and in the families in the immediate vicinity. The first case in our section, in 1853, was Lee, direct from New Orleans to the factory, and his companions and nurses were the next to suffer. The first case in 1855, was John Blacker, direct to Woodville from Vicksburg, where yellow fever was prevailing, and among the first after his case were those who were known to have visited him after his inception of the disease. If these are but accidental coincidences, they certainly occurred with a strange degree of regularity; not more, however, than that which has marked the progress of yellow fever along the course of commerce and travel. In holding the opinion that this disease is transportable and communicable, it does not follow that it may not be of domestic origin, whenever causes exist favorable to its production. Acknow- ledging my entire ignorance as to them, I will not trouble you with idle speculations. Respectfully, A. C. HOLT. III.- Yellow Fever in the Country: An Account of the Disease as it prevailed at Judge Baker's Plantation, Parish of St. Mary, Louisi- ana, in September and October, 1854. By C. R. Fassitt, M. D. The plantation of Judge Baker is situated nine miles below Franklin, on the bayou Teche. His residence is on the west side of the bayou, which here runs north and south. The negro quar- ters are below the residence, the nearest being a hundred yards, and the farthest about three hundred and fifty yards distant. The bayou is a hundred yards wide, and its shores connected by a bridge. On the east side, there is also a row of cabins, situated some sixty or seventy yards from the bayou, extending some two hundred yards. Opposite the upper part of this row of cabins, is a railroad for hauling out vessels. There were about one hundred and ninety negroes on this plan- tation, one hundred and thirty of whom had yellow fever. Six died, of whom two had black vomit, one a mulatto, and the other a black negro boy, aged about 10 years. One other was said to have vomited black matter, but I did not see the matter ejected. This plantation is not usually more sickly than others in the 47 neighborhood. The negro houses have plank floors, and are as comfortable as such houses usually are found. There had been no disease prevailing to any extent before the appearance of the fever in September. The houses are so situated as to form quite a town, and the streets, during the whole of the month of September, were in a most wretched condition, being a foot deep in mud. The origin of this fever is the only matter of special interest connected with its history. The barque Tivoli sailed from New Orleans towards the last of August, and reached Last Island, where, on account of sickness on board, she came to anchor, and there remained until the 5th of September. Two men died of fever on board, and the captain was brought to Centreville, having had fever also. He was very yellow and much debilitated, and one of the physicians who saw him, told me that he considered his disease yellow fever. On the 5th of September, the Tivoli was towed in from Last Island by Judge Baker's steamboat Picayune, and left at his plan- tation. Here, at the railroad, on the east side of the Teche, she was overhauled and cleansed while within a hundred yards of half a dozen negro cabins. The hands of the Picayune (all of them negroes and mulattoes), were the first who were attacked with fever. They had been on board of the barque, and had cleansed and smoked her hold, and were taken sick within ten days after. I did not see them until the 26th September. I was then told that all of the hands of the Picayune had been sick, but were re- covering slowly; for although they had no fever for several days, they were very much debilitated. One mulatto, who had had but little fever, complained very much of prostration, and I found his pulse at forty-five per minute. Another man, also a steamboat hand, had slight bleeding from the gums. There were many new cases at this time, in all, some twenty negroes were " laid up with fever." The number of cases steadily increased until the 20th of October, when about fifty negroes were in the cabins. The first death occurred on the 4th October, and the last on the 17th November. On the 17th October, two cases occurred in white subjects. Mr. Anthony Baker and his cousin were both attacked on that day. The former had black vomit in two and a half days from the onset of the disease, and died on the fourth day. 48 The latter died on the ninth day, having had hemorrhage from the nose and gums, and black vomit. There were seven cases of fever among white subjects, and four deaths. The negroes for the most part were not seriously affected by the disease; many had the fever only twenty-four hours, but in every instance, greater prostration was observed than is usual in other fevers. The negroes in the cabins near where the Tivoli lay, were first attacked by the disease, and I did not see a single case in which the subject had not been on the east side of the bayou. I do not believe that yellow fever is contagious; that is, that one person having the disease can under ordinary circumstances com- municate it to another. But, here the cause of the fever, whatever it may have been, was evidently in the vessel, and was communi- cated not only to those who cleansed the hold, but also to all per- sons in the vicinity. The cause remained after the vessel had left, and evidently increased in intensity. Another reason why the disease became more fatal among ne- groes was the fact that, owing to the great number sick at one time, it was impossible to have them all well attended. C. R. FASSITT, M. D. I have it in my power to furnish the following additional facts relative to the barque Tivoli, obtained from a reliable source:- The Tivoli took a cargo from New York to Chagres. After dis- charging there, she sailed for Berwick's Bay, on the coast of Louis- iana, for the purpose of getting a cargo of molasses to take back to New York. After leaving Chagres, sickness broke out on board, sup- posed to be what is called " Chagres fever" a severe bilious remit- tent, and the distress was so great, that the vessel had to be taken to New Orleans. She arrived here in the midst of the epidemic yellow fever. A new crew was obtained, and she again put out for the bayous emptying into Berwick's Bay. It is presumed this new crew consisted of unacclimated men, and the vessel had hardly cleared the mouth of the river before yellow fever broke out on board, and prevailed to such an extent, that she had to be left to the mercy of the waves. She was cast on Last Island, from which she was taken by Judge Baker's hands. What occurred afterwards is graphically detailed by Dr. Fassitt.-E. D. F. 49 IV.- Yellow Fever in the Country: An Account of the Disease as it prevailed on the Coast below New Orleans, in 1854 and '55. By D. R. Fox, M. D. Dr. Fenner :- Dear Sir : In compliance with my promise, I will endeavor to give you an account of the yellow fever as it has occurred in this parish; but before doing so, I think it proper to give a general de- scription of the parish, its inhabitants, and its most prevalent dis- eases. This parish comprises all that narrow strip of land border- ing the Mississippi River on both sides, extending from within twenty miles of the city of New Orleans, to the mouths of said river, being about eighty miles in length, and averaging six miles in width. The tillable land extends only thirty acres in its widest portion, and about ten acres in its narrowest part back from the river; behind this, the land is too low for cultivation, is partially covered with water during the winter season, and is affected by the tides of the Gulf. During the summer it is comparatively dry, and is covered with a species of coarse grass. This prairie land, as it is called, extends only a mile or so back of the arable land; be- yond this, the land becomes low and marshy, covered by coarse reeds, and is intersected by a perfect labyrinth of bayous or natural canals which communicate with the gulf. The distance from the river to the gulf, I do not think is more than ten miles in its widest part, and one or two miles in its narrowest part. This parish contains forty-three sugar plantations, producing from twelve thousand to eighteen thousand hogsheads of sugar an- nually. In its lower portion there are many small rice farms, and this section produces more rice than any parish in the State. Oranges are grown also in considerable quantities, and contribute largely towards the supply of the city of New Orleans. Inhabitants.-This is probably the oldest settled portion of the State, and contains a greater mixture of the races than any other region in the United States. The largest proportion of these are descendants of the French. The balance consists of Anglo-Saxon, Spanish, Italians and Africans, and a mixture of these in all grades and proportions. There is a large free colored population in this parish. Scattered along at intervals between the plantations, are many small neighborhoods or settlements, as they are called, con- sisting chiefly of the native creole population. Of these settlements, 50 there are six, which deserve more the name of small towns or villages. 1st. The Jesuits' Bend settlement; 2d. Pointe a la Hache; 3d. The Ronquille settlement; 4th. The Burat settlement; 5th. TheBa- lize; 6th. The Southwest Pass. The Jesuits' Bend is situated on the right bank of the river (going down stream), and is twenty- three miles from New Orleans. It is divided into two portions, the upper portion being separated from the lower by two sugar plantations, making an interval of two miles between the two. The upper portion of the settlement contains eight families, within the space of six acres fronting the river, numbering in all seventy or eighty souls. The lower settlement contains about ten families, numbering in all between seventy or eighty persons. The next village is Point a la Hache; it is forty miles from the city ; it is the county seat; has a court-house, jail, and post-office; and contains within the space of a mile, probably two hundred persons. This village is on the left bank of the river. The Ronquille settlement is on the right bank, and contains nearly as many inhabitants as Pointe a la Hache. The Burat set- tlement is seventy miles from the city, on the right bank of the river, is in the vicinity of the present quarantine station, and has about fifty families. Finally, at the mouths of the river, are the Balize and Southwest Pass settlements, consisting of pilots and their families, numbering in all from twenty to thirty inhabitants. Diseases.-By far the largest portion of the diseases of this pa- rish are miasmatic, chiefly intermittent and remittent fevers, and so far as my experience goes, I have found them to yield readily to proper treatment, and they are not so often associated with local inflammations or congestions as I have observed in some other parts of the State. The next most frequent diseases are, dysentery and diarrhoea, particularly among the negro population. Many cases of Asiatic cholera occur annually; it prevails also more among the negroes than whites, and is more fatal to negroes. More cases occur in the spring (May and June) than at any other time. This disease is sometimes endemic on a plantation, while the adjoining ones would be singularly exempt from it. Pneumonia occurs during the winter months, but is generally mild and easily treated. Worms are very prevalent, particularly among the negroes, old and young. Tetanus, both idiopathic and traumatic, is of frequent occurrence, mostly among the negroes. 51 The charbon, or pustule maligne, has occurred here frequently; it is a common disease here among the horses, mules, and horned cat- tle ; a planter sometimes loses all his stock. In regard to the yel- low fever, I have learned some interesting facts. Situated as this parish is, so near the city, and there being a constant intercourse between the city and the various plantations and villages, by the means of numerous sail-boats, which stop along the coast, carrying produce of various sorts to New Orleans and bringing merchandise to the numerous settlements, and also by a steam packet, which regularly stops once a week at every plantation and village between New Orleans and the Balize, one would suppose that yellow fever would be a common disease among its inhabitants; yet, upon dili- gent inquiry among the oldest and most intelligent persons, I am informed that the disease has never shown a disposition to spread until the year 1854. I have heard of many cases occurring in per- sons who having visited the city, have returned home with the seeds of the disease in their systems, and have died, throwing up black vomit. They were surrounded by their relations and friends during their illness, and yet no one took the disease from them. And even in 1853, when this disease was spreading terror and desolation in the upper parishes, it did not prevail here, although there were several cases in persons who had contracted the disease in the city. I may mention that this disease has never prevailed among the negroes; at least no deaths have occurred among them from this disease in this parish. Another interesting fact was related to me a few days ago by an intelligent planter (a creole, who has resided here all his life); he says, that within ten or twelve years, many of the creoles here have sold their small farms to the sugar planters, and have gone since to reside in New Orleans. He can count upwards of twenty persons of his acquaintance, who, although many of them have now resided in the city several years, yet, upon diligent inquiry, he can learn of one case only of yellow fever among them. In 1854, our parish seems to have lost its immunity from this pestilence. I was called on the 12th of September, 1854, to see an Italian, named Vincent, resident with a creole family. This family is in the upper Jesuits' Bend settlement, and consists of six persons, viz: the mother, a son eighteen years old, two younger children (one girl, ten years, and a boy eight years), also a married daughter aged seventeen years, and her husband (an Italian). 52 I learned this man had come from the city the day previous, and that he was unacclimated; had never spent a summer in New Or- leans; had been in the United States four years. He had all the symptoms of yellow fever well marked, and was sick eight days in all. He recovered. Case 2. On the 18th of September, the little girl, aged ten years, was taken ill with the fever. I saw her twelve hours after, and she had unmistakable symptoms of yellow fever. She threw up black vomit, and died forty-eight hours after she was first taken ill. Case 3. The married daughter, aged seventeen (enceinte six months), was taken sick on the 24th with fever. The symptoms, though well marked, were mild. The fever lasted fourteen hours, and then subsided. I gave her quinine freely. The fever did not return. Case 4. The little boy, aged eight years, was taken on the 27th, having all the characteristic symptoms of yellow fever; was ill six days; was convalescent on the 4th. On the second day after the fever left his pulse was only fifty a minute. I gave him stimulants, and broth as nourishment. He improved and became rapidly convalescent. Case 5. The mother was taken on the 29th. Symptoms similar to the others. Was convalescent on the fifth day. The young man, aged eighteen, left the house as soon as the Italian was taken, and did not return for two weeks; he escaped the fever. The nearest house above was half an acre; it contained a large family, fourteen persons in all; no one had the fever. Another family, consisting of some fourteen or fifteen persons, residing half an acre below, became alarmed as soon as the nature of the disease was known, and left their house and went into the lower settlement; no one had the fever. No cases of fever occurred out of the infected house. As soon as the nature of the disease was known, no one visited the house. A neighboring planter kindly sent a negro woman, who was acclimated (having lived in New Orleans), to nurse the sick. I wish I could give you a correct account of the fever as it oc- curred in the other settlements, but I have tried in vain to get at the particulars. All that I have learned is, that ten days after the disease made its appearance in Jesuits' Bend, it occurred in the Burat settlement, the fourth village from the city. It is said to have been brought there in the same manner that it was brought to the Jesuits' Bend settlement, viz: by an Italian boatman. It 53 was very fatal, only two or three persons recovered. More chil- dren than grown persons had the disease. A physician of the Bonquille settlement, which is twenty miles above the Burat (the late Dr. 0. Hags), was sent for. He paid two visits at the village- contracted the disease, and died about forty-eight hours after he was taken ill. He threw up black vomit freely. He was attended by Drs. Egan and Boyer, who can inform you of the particulars of his case. He was visited and attended by his friends and relations, yet, no one else had the disease in the Ronquille settlement. About two weeks after the disease in the Burat, it prevailed at Pointe a la Hache, the second settlement from the city; it was thought to have been brought from the Burat settlement. The above were all the settlements in which the disease prevailed in 1854. September 3, 1855. During the last week in August, I was called to see seven cases of fever in one house, all sick at the same time, three white, and four blacks. Looking upon them as mere cases of bilious intermittent fever, I prescribed for them accord- ingly, ordering quinine to be freely given immediately on the sub- sidence of the fever. All these cases did well. Two days after, while passing the house, I was called in to see another member of the family, a young lady, of eighteen years, and found her ex- tremely ill. She was throwing up black vomit, and passing the same from her bowels. She had been taken ill three days previous with fever, accompanied with violent pain in the head, back, and calves of the legs. She was treated by her mother with the usual creole remedies in such cases, viz: hot pediluvia, cold applications to the head, frequent sponging with tepid water and vinegar. She had been given an emetic of ipecac, followed by a dose of Epsom salts, as her fever had continued without remission. She had taken no quinine. I found her restless-much frightened-skin hot and dry-pulse one hundred and twenty, but feeble-tongue dry, but not furred. She complained of soreness in the fauces. Sclerotic slightly yellow-tenderness over epigastrium-suppression of urine. I cupped over the seat of pain, and the pain continuing, applied a blister over the abdomen, and dressed it with morphine cerate-gave her ice to hold in her mouth. She continued to throw up black vomit at intervals of four or five hours, and died thirty-six hours after the black vomit began. She was given strong chicken broth as nourishment, and stimulants also. During the intervals of vom- iting, she was quiet and free from pain. She became extremely yellow after death. 54 As soon as this person died, the family removed to a vacant house, one acre distant from their dwelling. In six days after their removal, a younger sister was taken with the fever, and within the space of ten days, every member of the family had had the fever- white and black, fourteen in all. The following were the general symptoms of nearly all the cases; in some, the disease was much milder than in others. The disease began with violent pain in the head, back, and limbs; the face flushed. The fever began with the pains; the eyes were more or less red; the pulse varied from one hundred and eight to one hundred and twenty; the tongue in general was moist; bowels rather torpid; the skin was hot, but easily made to per- spire. In some cases, there was pain over the epigastrium, and some nausea at the beginning of the attack. Treatment.-I pursued the abortive treatment. The family had become alarmed, and I saw every case early. My plan was, first, to give a mercurial purge, blue mass or calomel, followed in four hours by castor oil. I endeavored to promote free perspiration, by means of hot mustard pediluvia and warm orange leaf tea, and keeping the patient under cover. As soon as free perspiration was established, I gave thirty grains of quinine in two doses, one hour or so apart. I gave it in this way for fear the stomach would re- ject the thirty grains at once, which was done in one or two in- stances. Under this treatment, the patient was relieved in from fourteen to twenty hours. I kept them in bed until after the fifth day-on the second day, I gave the following diaphoretic mixture to keep the skin moist. B.-Aqua camphorae ; Spt. nit. dulc., Spt. mindereri, aa 3 ss; Paregoric ^ss.-M. A tablespoonful every two hours. I gave them ice to hold in the mouth when it could be had; gave mucilaginous drinks, sometimes acidulated with oranges (green). On the second day, gave chicken broth, gradually increasing it on the third and fourth day. Some of the cases were exceedingly prostrated. To these, I gave stimulants cautiously (usually gave brandy julep). Besides the members of this family, I had four cases in the adjoining houses; most of them had been with the sick family as nurses. Free communication was kept up between the families. No precautions taken to isolate the disease. There was 55 a great deal of prostration considering the short duration of the disease; more so than in the ordinary fevers of the parish. In searching for the cause of this disease, I learned that the family had a negro woman hired in New Orleans. This woman came home sick with a mild fever, about six days previous to the first cases of fever in the house. She brought her bedding and many articles of merchandise with her. The woman soon reco- vered, and returned to the city. The first cases of fever in the family were among the negroes; in them the disease was more mild than in the whites. Up to the time of the sickness in this family, the neighborhood had been remarkably healthy, and the black vomit case is the first and only white death in my practice this year. Thus, I have given you an imperfect account of the yellow fever as it has occurred in this parish. I have endeavored to give all the facts in regard to the supposed origin of the disease. I do not pretend to theorize upon them. I only vouch for the accuracy of my own cases. I did not deem it necessary to go into the minute detail of every case, with symptoms and treatment, although I have taken notes of most of them. Hoping you will make due allowance for all imperfections, I remain, your friend, D. R. FOX. V.-A Report of the Yellow Fever at Centreville, in 1855, with some Remarks on the Disease as it appeared in the Parish of St. Mary, in 1853, '54, and '55. By Wm. B. Wood, M. D. Centreville, situated on the Bayou Teche, in the Parish of St. Mary, in the midst of a very densely populated sugar-growing region, five miles below Franklin, and twelve miles above Patter- sonville, contains a population of about 200. In September, 1853, the yellow fever made its appearance at this place, for the first time, as an epidemic. Indeed, so far as I am in- formed on the subject, for the first time in any shape. An account of that epidemic has already been published in the " Report of the Sanitary Commission of New Orleans, on the epi- demic Yellow Fever of 1853," and also in " Dr. Fenner's report to the American Medical Association, on the Yellow Fever and Cho- lera of 1853." During that epidemic, about 45 or 50 cases of fever occurred in 56 the village, between the 18th of September and the 18th of No- vember, the period at which the disease disappeared. It also prevailed in an epidemic form at Pattersonville, at the same period of time (an account of which was published by Dr. Grout, of Pattersonville, in 1853), and in other portions of the Parish below this; while the upper portion of the Parish, including the town of Franklin, remained entirely exempt from yellow fever, with the exception of one family in Franklin, a report of which was made by Dr. Lyman, of Franklin, in a letter to Dr. Fenner, and published in New Orleans in January, 1854. In September, 1854, the yellow fever again appeared in Patter- sonville in an epidemic form, and also at Franklin, and upon the plantation of Judge Baker, four miles below Centreville. Of these places, Franklin, and Judge Baker's plantation, were severely scourged, while Centreville, lying midway between, remained en- tirely healthy during the whole season, escaping the yellow fever altogether, with the exception of two or three cases, contracted in Franklin. Of these cases, one died with black vomit, in our midst, and yet the disease failed to spread, or communicate to any one else in the village, notwithstanding many were exposed to it who had never had yellow fever. Does this fact favor the doctrine of contagion ? But let us follow its history on another year. And this brings us to the period more especially for which this report is intended. The history of the fever at Centreville, for 1855, presents more than ordinary interest, from the fact, that at one time in its progress, it was admitted on all hands to be genuine yellow fever by those who examined the cases, and, at another time, disputed by those who had already conceded the fact. There was another class also, who, having neither the courage to approach near enough to the village to examine a single case, nor the capacity to judge correctly of the facts, could, standing off at the safe distance of five miles, in company with the publisher of that interesting 8 by 10 sheet, at Franklin, styled " The Planters' Ban- ner !" assert most positively that there had not been a single case of yellow fever at Centreville, and that the disease which prevailed there, in an epidemic form, and pronounced to be yellow fever by six physicians, all of whom had examined the cases, was in fact nothing but "Dengue /" But to the history. In September, 1855, we find the fever again making its appearance at Pattersonville and Centreville about the 57 same period of the year, and in exactly the same form that it did in 1853, prevailing to about the same extent in Pattersonville as in 1853, but to double the extent in Centreville with regard to the number of cases, and perhaps a little milder in its type, while the town of Franklin, scourged in 1854, remains entirely free from epidemic yellow fever in 1855. We hear nothing in 1855 of " barriers thrown across the public road a half mile below the town of Franklin," as in 1853, and an armed guard stationed there to " fence out" the yellow fever, and to keep off the citizens of Centreville and Pattersonville from Frank- lin, lest some of the poisonous infection might attach itself to the clothing of those coming into the town, and Franklin become again the victim of a yellow fever epidemic! On the contrary, the most constant and intimate intercourse is kept up between the three places during the whole prevalence of the epidemic, both by the bayou and the public road, and yet Franklin remains, as in 1853, uninfected. Does this state of things favor the doctrine of contagion and importation? Not at all! But, say the advocates of this doctrine- and, of course, the advocates of quarantine-as this disease failed to communicate itself to our town and become epidemic, and as there were some eighty or ninety cases of the fever at Centreville and only one man died, it could not have been yellow fever, and must have been some other disease ! It did well enough for yellow fever at Pattersonville, because a good many died! Symptoms all right at Centreville-looked exactly like yellow fever! acted exactly like it in all its stages; but as only one man could be found in the place possessed of sufficient patriotism to give the disease a fair chance at him, and in the conflict to fall a victim-not only to the disease but perhaps to his own folly-that therefore it could not have been yellow fever! But they must give the disease a name, at all events. It would not do to call it bilious fever, as that disease never appears in an epidemic form of this kind. It would not do to call it intermittent fever, because the fever was not of an intermittent character. It would not do for scarlet fever, for there was no scarlet appearance of the skin, and sore throat. It would not do to call it "ship fever," or "Chagres fever," because the bark "Tivoli" hadn't been around this fall, to be " overhauled and cleaned," after lying high and dry several weeks, entirely empty, on the sand-bar at Last Island ! It would not do to call it the hooping-cough, because of there being 58 no cough that could be heard! But as " Dengue" was a term not well understood, and might be used to mean almost anything, it suited the purposes of the "wise men of Franklin," through their organ, the Planters' Banner, to christen the yellow fever at Centre- ville in 1855 " the Dengue!"1 Some of these Franklin people are great contagionists and quaran- tinists. They could see no possible way for the yellow fever to get into Franklin in 1853, and appear in the family of Mrs. Smith alone, as it did, except through the medium of a " box of axes" or a " paper package containing India-rubber coats," arriving directly from New York in a vessel by the way of Centreville! And, strange to say, the "negro man who carried them" from Centreville to Franklin, and the clerk in the store who received and opened them at Franklin, escaped entirely. Again, in 1855, we find that two persons actually die of yellow fever, with black vomit, in the town of Franklin-Captain Leaky, disease contracted at St. Martinsville, and Mrs. Cooper (how con- tracted unknown), and the yellow fever fails to spread or to com- municate itself to a single individual among all the nurses and attendants ! And yet we find persons contending everywhere that yellow fever is a contagious disease, and nothing but quarantine regulations can prevent its spread ! But let ns proceed with our examination into the history and symptoms of the epidemic fever, as it prevailed at Centreville in September and October, 1855, and determine, if we can, whether the physicians who examined the cases and treated the disease were right in calling it yellow fever. During the months of May, June, and July, there prevailed in Centreville and in the surrounding country the usual amount of intermittent and remittent fever, mild in type and yielding readily to medical treatment. We had also, especially in June, July, and a part of August, among the negroes on many of the plantations, the flux, which was often troublesome to manage, and sometimes fatal; and the hoop- ing cough prevailed extensively among children the whole season. The spring and early part of the summer were unusually dry; but in July and the early part of August very large quantities of rain fell, and the rays of the sun were exceedingly hot, and flies and mosquitoes became very numerous. During the month of August there were a few cases of bilious remittent fever on the plantations around, but scarcely a case of fever of any kind occur- 59 red in the village during August and up to the time of the epidemic on the 8th of September. On the morning of the 9th of September I was called to visit Mr. Hine, a merchant of our place, who was taken sick on the evening before with a slight chill, followed by fever, violent pain in the head, back, and eyes; eyes suffused aad injected, and very sensitive to light; complained of great pain in the eyeballs; tongue rather clean, and pulse about 110. His fever continued between two and three days, and went off very gradually. On the 9th another case occurred, Mr. Bonta; on the 10th two others, Mrs. Whitworth and George Rogers; and in less than ten days there were between thirty and forty cases of exactly the same kind of fever under treatment in the village, and this, be it remembered, out of a population of only about two hundred. Of these four cases, three of them were under my treatment, all of which I pronounced yellow fever. The other case, treated by Dr. Fassitt, was pronounced by him to be yellow fever at the time. Subsequently, Drs. S. Allen, C. M. Smith, and J. W. Lyman, resident physicians of Franklin, came down to Centreville, and were invited by me to visit and examine some of the cases under treatment at the time; and all of them gave it as their opinion, after so doing, that the disease was genuine yellow fever. Dr. Ethan Allen, another physician of our place, was taken sick himself soon after the outbreak of the fever, and saw very few of the first cases, enough, however, to satisfy him, as he told me, that the disease was yellow fever, of a mild type. Dr. Fassitt, who treated a number of the cases during the epi- demic, entertained no doubt of the disease being genuine yellow fever, until his patients refused to die! and so expressed himself to several persons in and out of the village. This fact was sufficient, perhaps, to create a doubt in his mind, when he reflected upon the success which attended his practice in the treatment of the yellow fever of 1853 and 1854. But I am of opinion that if he had pur- sued the same practice in 1855 that he did in the yellow fever of 1853 and 1854, he would have had no grounds to doubt, at least upon that score. He treated the man (from the third day of his illness), who died at the hotel on the 23d of September, and in- formed me that a dark looking matter, which ran freely from his nose and mouth some twelve hours after death, was, in his opinion, genuine black vomit. This corpse I also examined myself, some twelve or fourteen hours after death, and I entertained no doubt, 60 from the appearance presented, and from what I had learned of the history of the case, before death, that this man's disease was yellow fever. And I agreed with Dr. Fassitt, in the opinion expressed, that the dark matter running from his nose and mouth at the time, was genuine black vomit. Indeed, I have not the slightest doubt on that subject. It was as pure looking black vomit as I ever saw thrown from the stomach of any case of yellow fever. This man was a German by birth; appeared to have been but a short time in the country, as he could speak but little English; was a carpenter by trade, and had been at work in Centreville but a month or two when taken sick. When attacked with the fever, he refused to allow a physician to be called to treat him, and under- took the management of his own case. From this circumstance (and all the cases appearing to be of a manageable type), I felt anxious to see how a case of fever would terminate when left to nature and the nurse. And hence I watched the progress of his case from time to time as I passed by the door of his room at the hotel, while attending to a patient of my own in the next room, with the same disease. And from what I was able to see myself and learn from his nurse, a countryman of his, who attended to him, I found that he was taken sick exactly like a ma- jority of the cases under treatment in town, viz., chill, followed by fever, pain in the head, back, and eyes. Eyes injected, and very red; tongue clean and moist at the onset, and looking almost natu- ral. Indeed, I did not find a dry tongue among all the cases I attended during the epidemic. Skin hot, in this case, but easily induced to sweat; pulse from 110 to 120; the fever continuing along from day to day, with no intermission, and very slight re- mission. He had, from time to time, hemorrhage from the nose and gums. The pain in the head and back continued, with the fever; and the nurse said he never slept at all. His treatment, in the beginning, consisted of a dose of rhubarb, followed by castor oil, which acted freely on his bowels, and his discharges appeared consistent. He kept very quiet in bed, drank warm tea from time to time, and sweated freely, for the two or three days that I noticed him, and I thought, at one time, that he would recover. However, getting no better, I presume, about the third day of his illness, Dr. Fassitt was called in to take charge of the case (as I was informed), by Cary, the hotel keeper. After this period I saw 61 little or nothing of him until the evening of the fifth day of his attack, when he was said to have spasms, and I walked into his room in company with Dr. Fassitt. He was then struggling with strong spasms, and requiring the exertions of two men to hold him in bed. His face was flushed, and his pulse strong and full. Dr. Fassitt corded his arm and bled him from a free orifice, about a quart. Blood dark, and appeared to coagulate in the bowl. Under the bleeding, he calmed down. I know not if anything else was done for him at the time, as I shortly after left the room. Dr. F. being called away shortly after, requested me to call back to the patient's room again and see him. I did so in about an hour, and found him dead. Had this man's case not terminated fatally for twenty-four or forty-eight hours longer, I believe he would have thrown up black vomit before death. As it was, the blood was not sufficiently dis- solved to enter the stomach through the coats of the mucous mem- brane. He had, however, as before stated, hemorrhage from the nose and gums, before death, and I am fully satisfied the dark matter running from his mouth and nose, at the time I saw him, 14 hours after his death, was the genuine black vomit of yellow fever. This was the only case of fever that died at Centreville during the epidemic, out of some 80 or 90 cases, and this was the only case that was not promptly treated by a physician, from the beginning of an attack. The fever was uniform in its character in every case; continuing without any intermission, and very slight remission, for from two to four days; and once off showed no disposition to return again, except in case of a relapse. Indeed, in every case, it was a fever of one paroxysm, lasting about three days, attended in all cases, with more or less pain in the head, back, and eyeballs; the pain generally continuing along with the fever, and going off only as the fever subsided. In some cases, there was bilious vomiting in the beginning of the attack. In at least one-half of the cases, how- ever mild, there was more or less hemorrhage from the nose and gums; and in many of the more violent cases, there was tenderness over the region of the stomach, with vomiting, belching, and hic- cup, and in every case there was very great prostration of strength following the decline of the fever. The red and injected appear- ance of the eyes was generally followed by a dull yellow look of the conjunctiva, and yellowness of the skin attended many of the worst cases of the disease. 62 The fever began to abate after the middle of October, and by the 10th of November had disappeared entirely. And in this particu- lar resembled exactly the course of the epidemic of 1853, which lasted about 60 days. Indeed, I could discover no difference in the symptoms and cha- racter of the epidemic of 1855 and that of 1853, at Centreville. Both observed not only the same laws in their progress, but the same geographical limits within the village, extending as far up and down the bayou, and along the public roads, as in 1853, and no farther. As in 1853, it refused to extend itself into the surrounding country. Several from the country exposed themselves to the disease in the village, contracted the fever, returned home, were nursed and attended by their families during the period of their illness, and yet not a solitary instance occurred, in which the fever was communicated to a single individual member of the family, outside of the village. This was the case also in the epidemic of 1855. The disease could only be contracted within the limits of the infected district, and was not capable of propagating itself from person to person in the country, among those exposed either by contagion or infection. One argument used by those who contend that the disease could not have been yellow fever in 1855, is that the fever attacked all persons indiscriminately; those who had had the yellow fever in 1853, as well as those who had not. This is not a fact. I do not believe a single case occurred in Centreville of well marked yellow fever, during the epidemic of 1855, in the person of any one, supposed to have had genuine yellow fever during the epidemic of 1853. My opportunities of judging correctly on this point will certainly not be disputed, as I treated nearly all the cases in 1853 in the village, and a large majority of them again in 1855. I know that some few had fever during both epidemics. But when we understand that every case of fever that occurred during the two epidemics was not yellow fever; and that a number of cases of plain intermittent fever, and a few cases of well marked remittent bilious fever, so plain that a nurse could at once detect them-occurred during the epidemic in both years; then, it is not to be wondered at, that some few persons who had fever in 1853, should have fever again, of one sort or another, during the epidemic of 18551 In the family of John Rogers, his wife alone had yellow fever in 63 1853, while in 1855 every other member of his family, himself in- cluded, had yellow fever; his wife nursed them all; and yet she escapes the fever entirely in 1855. In the family of Ralph D. Smith, his wife and daughter alone had yellow fever in 1853. In the epidemic of 1855, nearly every other member of his family, himself included, had the fever, and the wife and daughter escape. Other instances of a similar character could be given, but these are deemed sufficient. Whole families escaped in 1853, and were nearly all sick during the epidemic of 1855. Dr. Fassitt thinks he had the yellow fever in 1853, and says, he had the prevailing fever during the epidemic of 1855. And this, I understand, to be the second ground upon which he predicates his opinion, that the epidemic fever of 1855, at Centreville, was not yellow fever. It was a very easy matter for him to have been mistaken in his own case. Physicians are not always the best judges in their own cases. And, it is also possible for Dr. Fassitt to have had yellow fever both seasons. Persons have undoubtedly had the disease twice, if we are to rely upon reports made by physicians, and I am sure I am not prepared to say that a person might not have yellow fever, even oftener than twice under some circumstances. Some expose themselves freely, and never have the disease at all. This has been my own case. Although exposed to yellow fever in 1843, 1847, 1853, 1854, and 1855, I have so far escaped the dis- ease entirely. Entertaining no fears for my personal safety during the prevalence of yellow fever as an epidemic, perhaps has contributed more than anything else, to my entire exemption from the disease, during the several years in which I have been exposed. The treatment adopted at Centreville, during the epidemic of 1855, was very simple and very successful. That which I had used here so successfully in the yellow fever of 1853, was the general treatment which was followed in 1855. The disease being mild in its type, and no panic arising among the citizens on the subject of the epidemic, it yielded more readily to medical treatment. A mild mercurial cathartic at the commencement of the fever, followed, some hours after, by a moderate dose of castor oil, to 64 evacuate the bowels fully; together with warm orange-leaf tea as a drink, and hot mustard foot-baths, to induce free perspiration dur- ing the continuance of the fever; and perfect quiet in bed under blankets, constituted, generally, the medical treatment during the paroxysm of the fever. In some few cases attended with vomiting at the beginning, a gentle emetic of mustard and common salt, in warm water; or, of ipecac., was given first to empty the stomach, and to assist in de- veloping the fever. This generally induced free perspiration at the start, and tended somewhat to lessen the pain in the head and back. No nourishment was allowed until after the fever began to subside, or most generally, until after it had gone entirely off, when gruel, chicken water, or beef-tea, were allowed in small quantities; and brandy toddy, brandy julep, or champagne wine in ice, were given in such quantities as nature required, and the stomach would bear. While the fever was subsiding, or after it had gone off, a dose of sulph. morphine was sometimes administered, to quiet nervousness and induce sleep; when this could not be taken safely, owing to any idiosyncrasy in the case, a stiff brandy toddy was sometimes given, with a very good effect. No change was allowed to be made in the bedding or clothing of the patients, between the period when the fever subsided, and the sixth or seventh day of the attack, and the most perfect quiet enjoined upon them, until after this period. This, as a general thing, constituted the treatment pursued in a majority of the cases. Some cases, differing from the general run, being more violent in their type, required some modification in their mode of manage- ment. Speaking of the use of brandy toddy in this disease, I will here remark, that it will be found one of the very best remedies we can use to arrest black vomit, and save the life of the patient, after that alarming and fatal symptom has made its appearance. In one case which I had in November, 1854, of a lady on Bayou Sale, in this parish, the wife of a sugar planter, I arrested black vomit, which had continued at intervals for six hours, to be thrown up in small quantities, by the free use of brandy toddy alone, and the lady is now living to testify to the fact. And although I have seen several die with black vomit, this was the first case of recovery in an adult that I ever witnessed myself, after that fatal symptom had supervened. My manner of using the brandy toddy on the occasion, was this: 65 I mixed half a glass of the strong toddy at a time, and then gave the patient two or three swallows of it, after every effort at vomit- ing. At first, the toddy was instantly thrown up, and the patient de- clared to me that it was too heating to her stomach, and that it made her vomit more. To this, however, I paid no attention, I had tried so often before, almost every remedy that suggested itself in such cases, and failed to do any good; and I had tried the plan of keeping everything out of the stomach, and yet the case would die, whether the vomiting ceased or not; that in this case, I determined to push the brandy, and give the remedy a fair trial. And after every effort at vomiting, which came on at intervals of about ten or fifteen minutes between, I gave a few swallows of the toddy- strong toddy-for my patient was fast sinking, with cold clammy skin, small pulse, and hiccuping at every breath. In about an hour's time the toddy began to stick on the stomach, and the black vomit to be thrown up in smaller quantities, and requiring great effort; and in three hours' time, I had not only arrested all vomit- ing, but I had obtained a warm healthy glow of the skin, and the pulse had become full and round. She was kept very quiet, and for the twenty-four hours that fol- lowed she took nothing on her stomach but small quantities of the brandy toddy, at longer or shorter intervals, as the state of the skin and pulse seemed to indicate. On the second day, I substituted champagne wine for the brandy toddy, and allowed some arrow- root gruel, which was followed by broth, etc. As stated before, the lady recovered, and is now in the enjoyment of excellent health. A few words as to the origin and spread of yellow fever, and I will close this report. I do not believe yellow fever to be conta- gious. I have seen much of the disease for several years past, and I have been unable to discover a single fact, which could induce a belief in my mind, that the disease is contagious; or, that it can propagate itself from one person to another, as we know that small- pox, measles, and other contagious diseases, possess the power to do. I believe the poison which gives rise to yellow fever, to exist in the atmosphere; is generated under peculiar circumstances, re- quiring the influence of certain degrees of heat and moisture, added to animal and vegetable decomposition; that this power, when gene- rated, is of local origin, and confined to certain circumscribed dis- 66 tricts of country, or portions of our country; and that all who enter within that infected circle, and breathe the air, are liable to take the disease. That this poison did originate spontaneously at Centreville, both in 1854 and 1855, and that yellow fever here, owed its origin to local causes, and not to importation from any other place; that yel- low fever will not always spread from the introduction of a case of the disease into a family or community, is established by the fact, that it failed to spread at Centreville, when introduced in 1854, and also, in Franklin, when introduced in the persons of Capt. Leaky, and Mrs. Cooper, in 1855, notwithstanding the disease had pre- vailed in an epidemic form only the year before, at both places, and cases terminating in black vomit were introduced in both in- stances, and the whole community were more or less exposed. Indeed, a hundred instances could be given of just such facts, of persons dying with yellow fever at different places, and nobody else contracting the disease. In some instances, as was the case in this parish the past fall, a whole family, consisting of the father, mother, and two children, all died of yellow fever in one house, while on a visit to a relative; and although nursed by the members of the family of the relative, at whose house they were visiting, not a single case of the fever occurred among all the nurses and attendants! None of the first cases that occurred at Centreville this fall, had been exposed in the slightest degree to yellow fever, from any other point. It is true, Mr. Hine had returned from New York, about fifteen days before his attack. But he came down the Ohio and Mississippi rivers, and not by New Orleans; and in coming home, never made the least stop at any place where yellow fever was sup- posed to exist. Of the three other cases taken sick about the same time, none of them had been out of Centreville to expose them- selves. All lived in different parts of the village, and only two of them had been near enough to Mr. Hine to speak to him since his return from the North. Centreville, La., December, 1855. VI.- Yellow Fever in Thibodeaux, La., in the year 1854. By M. A. McLeod, of Thibodeaux. Previous to the appearance of the yellow fever here this year, we had very unsettled weather-rain almost every day-yet there was nothing in or about the town that would indicate sickness of any 67 kind, and up to that time during the summer, the place had been remarkably healthy. The first case occurred in September. On the 12th day of that month, I was informed that there was a case of yellow fever in town; the sick man was an Italian, who had recently returned from New Orleans; yet, the attending physician did not pronounce the case yellow fever (perhaps not wishing to create an alarm). My informant was one of the nurses, and non-professional, but he had seen and nursed a number of cases of yellow fever the previous year, and he did not hesitate to pronounce this a well developed case of that disease. The Italian recovered. On the evening of the 20th of September, some of our unacclimated citizens became alarmed; it was reported that a tailor on the opposite square from where the Italian was sick, was dying of yellow fever, and I was asked to go, and if possible, ascertain the correctness of the report. I called at the house next morning, but the man had died during the night. I met the attending physician (who was the same that had treated the Italian), but he gave me very little satisfaction in regard to the case, and stated that the patient had thrown up black matter, but he rather looked upon his disease as cholera. September 22d, a woman, near the above, and on the same street, and opposite to where the Italian was sick, died this day of yellow fever, pronounced such by her attending physician, Dr. J. W. Dea- drick. A German gardener, who resided four miles above the town, was in the place, and assisted in putting the corpse in the coffin, and attended the funeral. He went home, and a few days after he was taken with fever and was removed back to town. On the night of October the 4th he died with black vomit. This was likewise the patient of Dr. J. W. Deadrick, and it was the first case of black vomit I saw this year. About this time, the fever ap- peared to have spread pretty much throughout the town, and all our physicians reported a greater or less number of cases, which alarmed the unacclimated, many of whom fled to the country, and remained there secure until we had frost. Now, I have no doubt but the first case of yellow fever here this year, was the Italian's, and he brought the disease from New Or- leans, and from him it spread throughout this place. We could not trace it distinctly from one person to another, yet, there are some few cases where we could trace it distinctly, such as the fol- lowing :- An Episcopal minister (Mr. Trader), who came to reside here 68 last spring, and was unacclimated, visited a young man who lay sick with fever, and a few days after, he went about a mile in the country (at Judge Guion's), to dine. After dinner it rained, and he was prevailed on to spend the night; some time in the course of which, he was taken with yellow fever, and remained there until he was convalescent. A few days after this, the family where this man was staying, were taken with the fever, and one, a very inte- resting daughter, died. A son-in-law of Judge Guion, Dr. Young, who resided in Houma, sixteen miles from this place, where there was no yellow fever, came up with his lady to attend on the sick, and while there, they were both taken with the fever, and the Doc- tor died. There are other instances here where the disease appeared to spread by contagion, and, in fact, it was far more traceable from person to person, than an epidemic of smallpox has been, which we have but recently passed through here. A man came from New Orleans here with smallpox, and so soon as it was ascertained that he had the disease, he was removed with- out the limits of the town, where he died, and his clothes were there burned. Yet, in ten or fifteen days after this the smallpox broke out in all quarters of the town, the cases within a few days of each other. In the most cases it was in persons who had not been near the sick man, and I look upon it just as easy to account for the spread of one, as the other. I do not pretend to say that the con- tagion of yellow fever is as virulent as that of smallpox under all circumstances, yet,, it may be so in tropical climates where it is en- demic. I look upon yellow fever as an imported disease, and whenever this or any other climate assimilates in temperature and other things that where yellow fever is indigenous, let the conta- gion once be started, and it will spread from person to person, until we have a change in temperature to check it. The fever continued to attack the unacclimated until we had a killing frost, which occurred on the 15th of October; and even after this we had a good many cases, but it was among persons who had been exposed to the disease previous to the frost. One recovered after black vomit in my practice. Now, in regard to the treatment, so much has been said, that I deem it unnecessary to speak of that in detail. But I look upon it, that remedies that might be found efficacious in one locality, might not answer so well in another, as the yellow fever, I think, is apt to partake of the nature of the prevailing disease of the particular localities where it 69 spreads, and no doubt requires to be treated accordingly. And this will account, in a measure for the different successful treatment in different places, although they may be the opposite of each other. The treatment I found most efficacious, was to open the bowels freely at the start; mustard foot-baths and warm teas, until the fever had subsided; and then, stimulants or not according to cir- cumstances. I used very little quinine. The muriated tinct. of iron I used to some little extent, but not sufficiently to speak of its effects, either pro or con. VII.-An Account of the Epidemic Yellow Fever at Cooper's Wells, in Hinds County, Miss., during the Summer and Autumn of 1855. By J. S. Beazley, M. D. I visited Cooper's Wells in November last, after the subsidence of the memorable epidemic, and must confess, I could discover no evidence of a local cause that I would consider capable of giving rise to such a disease. I therefore think there must have been some foreign influence, or else a very extraordinary condition of the atmosphere, that caused the endemic fevers of the place to assume or run into the yellow fever type. You will perceive, that Dr. Beazley mentions the abundant prevalence of intermittent fever at the time of the outbreak of yellow fever. To use his own language, "the change was gradual, a running into yellow fever as it were." The Doctor appears to attach much importance to the apparently infectious communication that could be traced in every instance where cases occurred in the neighborhood, with the exception of one family; but, strange to say, that was the only case in which the disease ran through the whole family. This would appear to prove the necessary presence of some local cause or influence at that spot, or, at least, that the disease is incapable, per se, of regenerating its own poison, and thus spreading from person to person. The facts bearing on this point that have been observed within the last few years, really appear to be so contradictory, that it is almost impos- sible to get at their true meaning. I am happy to find some of my own observations and conclusions respecting yellow fever, sup- ported by the testimony of Dr. B.; such as the close relationship between the different types of fever prevailing, and the difficulty of distinguishing them-the extraordinary mildness of the symptoms in many cases, as I witnessed in the Norfolk epidemic-attacks sometimes attended with bilious vomitings, contrary to the rule laid down by Dr. Nott, of Mobile; the beneficial effects of sponta- 70 neous hemorrhages from the nose and gums; the fatal effects of suppression of urine, etc. In short, Dr. Beazley's letter is very valuable, and I commend it to the special attention of your readers. E. D. F. Cooper's Wells, March 6th, 1856. Dr. E. D. Fenner-Dear Sir: Agreeable to promise, I will en- deavor to give you a short history of the epidemic, as it occurred at Cooper's Wells during last summer. Not having taken notes of the cases under treatment for yellow fever, I cannot enter into a minute description as to symptoms, or management in any parti- cular case. My object will only be to give you a general outline of the prevalence of the fever at this place and vicinity. The visitor on arriving at Cooper's Wells, will not fail to be struck with the high and elevated location of this justly celebrated watering place, the romantic scenery, and the rolling character of the country in every direction. Owing to its natural advantages in this respect, there can be no accumulation of filth, animal or vege- table; every shower of rain washing the hills clean, and free from anything that is calculated to produce disease. No swamp or low marshy places in the vicinity giving rise to malaria. Consequently, I think you will agree with me, from your know- ledge of this section of Hinds County, that there is no local cause at this locality, capable of originating yellow fever. The question then, very naturally arises, in the absence of any proof of the origin of an epidemic at this point, how was it communicated here? Whether by the transmission of goods and baggage from an in- fected district, or by persons having been exposed to, and inhaling the atmosphere of a yellow fever region, and coming to the W ells, the disease developing itself after their arrival? I will mention a few facts just here, and leave you to draw your own conclusions. A milliner, from New Orleans, came to this place early in the summer, rented rooms, and opened a lot of goods for sale, and was constantly receiving and opening boxes containing ribbons, silks, and fancy articles, from your city, during the prevalence of fever there. Several ladies who were frequently at her store and bought goods were attacked with fever, one of whom died with black vomit. This woman soon after took the fever, and also an Irish chambermaid, and several servants who occupied adjacent rooms. On the 8th of August (which was before the fever made its appear- ance in Vicksburg), there being an increase of company at the 71 Wells, the proprietor of the hotel went to the above-mentioned place, and purchased twenty mattresses, which were shipped imme- diately to this place. I mention this fact, because it has been fre- quently remarked and reported through the country that the mat- tresses were ordered from New Orleans. About the middle of August, two suspicious cases occurred, which created considerable alarm among the visitors, but not regarded as yellow fever by the attending physician, both of which died on the fourth or fifth day, with symptoms of fever, but no black vomit. Each of these cases came from a fever district a few days before they were taken sick. For a week or ten days there was no sickness of any description. On the 23d of August, a lady from Louisiana was attacked with fever; came through Vicksburg a short time before. On the 26th of August Dr. Pugh was attacked (the Doctor attended the cases above spoken of). Both of these cases died with black vomit on the fifth day. The prominent symptoms in these, as well as many other cases, were severe pain in the head, back, and calves of the legs, high fever, great thirst and restlessness, sick stomach, eyes injected, skin yellow, often hot and dry, and frequently a profuse sweat; but a steady, gentle perspiration, could not, in most in- stances, be kept up; tympanites and suppression of urine, coma and black vomit, would generally end the same on the fourth or fifth, and sometimes on the third day. During the week that the two latter cases were sick, I saw and treated some fifteen or twenty cases of well-marked intermittent and remittent forms of fever, all of whom got well, under a mild course of medication for those dis- eases. The fever then assumed a different type; the change was gradual, a running into yellow fever as it were, and spread rapidly, principally among the blacks. At the commencement of the epidemic, dating from the 23d of August, there were about four hundred persons at the Wells, white and black, exposed up to the 31st of August, when the first death took place. Yet, I only heard of two cases of fever occurring out of this large number after they left Cooper's Wells. All who remained were connected with the establishment, numbering fifty, white and black. Of these, four had had the fever previously, and one escaped an attack. There were forty-five attacks and nine deaths-six whites and three blacks. It may be well to remark that we had valuable aid in the persons of Drs. Hubbard, Buckner, and Brickell, of Vicksburg, and Dr. Cabaniss, of Jackson. And if a competency of good nurses could 72 have been procured, I am inclined to think, that the mortality would have been diminished to half the number reported, the majority of cases assuming a mild form. I was called to see a number of fever cases between the Wells, Raymond, Newton, and Jackson, all in the same county. Whenever I was called to patients in the coun- try, I endeavored to find out, if possible, whether they had, at any time, been where the fever was prevailing. They answered me invariably in the negative. But, on pressing my inquiries, I found that they had been brought in contact with goods recently received from an infected district, either at the store or by shipments made to them by their merchants at Vicksburg or New Orleans. Others had visited the rooms of the sick. In one family where the fever prevailed to an alarming extent, I was not able to trace the origin of the fever among them to any other agency than the transmission of some morbific matter through the medium of the atmosphere. The attacks here were violent. There were in this family twenty persons, white and black; nine were attacked (seven whites and two colored); three deaths, two whites and one black. This was the only place in the country that the fever spread to any extent in the same family. It has frequently occurred to me, during the epidemic last summer, that it was strange, where so many in the same family, often in the sick-room, and acting as nurses, did not have the fever, if, as some writers hold, yellow fever is contagious. I could mention several instances where only one in a large family had the fever without communicating it to any other member, notwithstanding the relatives mingled freely in the sick-room. In many cases that came under my observation the advance of the disease was very mild; the patient complained but little, generally of a fulness or tight feeling in the head, a sensation of weariness in the lumbar region, tongue slightly coated, often clean, and but little fever. In several instances it was difficult to determine at first whether the patient had the fever or not; but in a short time more urgent symptoms supervened and removed all suspense with regard to the true nature of the case. In others the attack was open and bold; high fever, severe pain in the head, neck, back, and limbs, very restless, sick stomach, with bilious vomitings, etc. I witnessed one case in which the patient at the onset of the disease became delirious-recovered after a protracted illness. In two others hunger was a prevailing feature, each attack mild. When hemorrhage occurred at the nose or mouth the case almost always terminated favorably. Black vomit was not common 73 in the epidemic here; but few recovered after this fatal symptom made its appearance. In one case that had black vomit the discharge by the bowels seemed to be pure blood; after standing a short time it coagulated into a solid mass. And in another who had black vomit, the dejec- tions were precisely the same as that passed from the stomach. Each case proved fatal. Suppression of urine was always a fatal symptom. When this secretion was scanty, or not voided for twelve or fourteen hours, it was often relieved by appropriate remedies. From the appearance of sudamina, convalescence most generally followed. In one case this eruption was superseded by a large number of boils all over the surface, from the size of a pea to that of a hazelnut. It will not be expected of me, from my limited experience in the treatment of yellow fever, to contribute anything new to the mode usually adopted; but a few remarks under this head on the course pursued here will close this communication. The treatment carried out was principally on the expectant plan, which consisted (after putting the patient to bed, administering foot-bath, etc.) of a gentle purge of some kind; calomel and rhubarb were used, but I saw better effects from a simple dose of oil. Of the different alkalies lime-water was preferred, given early in the attack and continued during sickness. The object was to keep up a gentle perspiration all the time. As long as the skin acted well, nothing was done for the patient, unless symptoms called for more active remedies, beyond the use of cold drinks to allay thirst and adding as much as possible to the comforts of the sick-room. When high fever came on, with great thirst and restlessness, ext. aconite was admi- nistered with good effect, in from quarter to half grain doses every three or four hours, in order to reduce the action of the heart, and also for its diaphoretic properties. But this, I think, is a remedy that requires watching, as there is already too great a tendency to sedation in most cases of yellow fever. Mustard poultices to the stomach, and enemas of cold slippery-elm water, repeated every four hours, I found to have a fine effect where the febrile symptoms ran high, hot and dry skin, thirst, and tenderness on pressure of the epigastric region. Very decided relief was afforded the patient in every instance. Mucilaginous drinks in small quantity, iced if desired; cold douche to the head; stimulating frictions, as pepper and hot brandy to the extremities, when the capillary circulation was languid, were used with advantage. After total suppression of 74 urine no case got well. Where the secretion was suspended for a few hours, or passed in small quantity, the infusion of uva ursi, with sup. carb, of soda, was given with happy results. In fact, it did not fail in my hands to restore this function to its normal standard. No particular remedy was relied on to check the ejec- tion of black vomit. After the febrile stage had subsided and the period of prostration came on, nourishing diet and stimulants to support the strength of the patient; chicken water and arrowroot often but in small portions ; brandy, porter, and ale, according to the taste. Without wearying your patience any farther 1 will finish by stating the number of cases that occurred both here and in the vicinity. There were in all seventy attacks of yellow fever, as follows:- Attacks-whites, 40; colored, 30-total, 70. Deaths-whites, 9; colored, 4-total, 13. Hoping you may find something in this communication that will in some degree aid you in making out your final report to the Medical Association, I am, with high regard and the best wishes for your future prosperity and happiness, Your friend, J. S. BEAZLEY. VIII.-On the Topography, Climate, and Diseases of Washington, Texas. By T. J. Heard, M. D. [The following paper from the border of the yellow fever area will be found interesting, as it touches upon the origin and rela- tionship of the different types of endemic fever.-E. D. F.] Washington, Texas, Feb. 8th, 1856. Dr. E. D. Fenner-Dear Sir: Dr. E. H. Hubbey told me a few days since, that you wished a paper from me on Yellow Fever. 1 have seen but little of the disease here; consequently, cannot have much to communicate on that subject as the result of my own observation; but I will give you an outline of my medical obser- vations at this place, and if you find anything therein of any value to the medical public, you are at liberty to use it as you think proper. I will in the first place briefly allude to the topography of this town. It is situated in about 30° 20' north latitude; 100 miles from the city of Galveston, and about 150 feet above the Gulf of 75 Mexico. It is on the southwest side of the Brazos River, and opposite the junction of the Brazos and the Navasota. The town is situated on a number of large hills, irregularly- arranged, and bluffing up to within 100 yards of the river. The river bank is about 50 feet high above low water mark. The hills are so situated as to permit all refuse to run off the streets, being swept off either on to the beach of red alluvium at the foot of the hills, or into the river. The Brazos bottom is composed mainly of red alluvial loam, abounding in terrestrial testacea, vegetable mould, &c., and varies from three to five miles in width. The river bank on the bluff shores, to a depth of fifty feet or more, has identically the same appearance and composition as on the surface. The red loam and vegetable mould lie in regular alternate strata, though the strata differ in thickness as determined by the depth of water over the bottom and the number of days it has been sub- merged by each inundation. The surface of the town site when first settled had the appear- ance of being little else than white sand. The stratum of sand varies from one to three feet in thickness. Below this there is a stratum of marl, with here and there sections of red clay and con- glomerate sandstone to a depth varying from ten to fifteen feet; and beneath this we have hardly anything but white sand, and occasionally sandstone. At a depth of from 30 to 70 feet large quantities of fossils are found, composed, not only of shells, but the bones of land animals, not only of the known but the extinct also. The rocks in this section are all conglomerate sandstone, abound- ing in water-worn pebbles and shells, chiefly marine. Springs are abundant in this section, and occur in almost every place where the rocks crop out, but the water is very impure, being impregnated with calcareous, argillaceous, and other mineral substances. Here, those who use spring or well water are not so healthy as are those who use cistern water. I will next cursorily allude to the early settlement of this place, and to disease as it was then, and as it has been modified since, up to this time. In 1820 and 1821, Mr. Andrew Robinson made a settlement on the river bank half a mile below the present town- site. He made it his home until 1833. He used river water prin- cipally (which is brackish), and had but little disease in his family. In 1834, the present site was laid out into lots, and sundry im- provements were made. The site on which the town is situated was densely timbered with post oak and thick hammock under- 76 growth. When the country was invaded in the spring of 1836, the population of the town was about 200. They nearly all fled before the invading army of Mexico, and had not all returned when I settled here in the fall of 1837. I was informed by the Hon. Anson Jones, M.D., and Mr. James B. Miller, that the diseases of the country prior to the time of my settling here, were simple in cha- racter and easily treated. They had both practised on the Brazos some ten or fifteen years before I came to the country. They treated cholera in Brazoria County at and near the mouth of the river in 1832 and 1833, but had never seen a case of it in the inte- rior. Intermitting and remitting fevers were the diseases they chiefly had to contend with. When I came here in 1837, the population of the town was about 500 citizens. Transient persons to a great number, consisting of disbanded soldiers, and adventurers from the States and Europe, flocked in rapidly. The town tract, about one mile square, was strewed with the boughs of the trees that had been felled for building, and other purposes. We lived badly. We were neither well fed nor com- fortably housed, and we drank bad water; hence, we had a great deal of disease, consisting mostly of intermitting and remitting fevers, with some cases of diarrhoea and dysentery. The great quantity of vegetable matter in a state of decay, not only the boughs of the fallen trees, but a great amount of vegetable mould on the surface which had been for ages accumulating, and had been in the mean time sheltered from the rays of the sun, were at once exposed to his direct rays. From these causes poisonous emanations took place to a great amount, and sickened every per- son in town. This state continued until 1843, with very little variation. To pass a season in our town without one or more attacks of fever was almost a miracle, though our fevers were almost in every instance open and mild and readily yielded to treatment. 1843 is long to be remembered by old Texans. It rained almost the entire year. Our prevailing winds here are from the south, and our country is almost always healthy while they are regularly from that direction. But this year there was no regularity in them; we had no regular currents in the atmosphere. The winds amounted to little more than an ebb and flow. The clouds Were often stratified, sometimes as many as three or four strata moving in different directions. The alternations of temperature were great. 77 Suffice it to say, disease was sown broadcast. Everybody was sick, and the fevers put on different livery from anything I had seen before. Ordinary congestive fever was common and of the most fearful type; the algid was by no means uncommon. With the return of cold weather, health was again restored to our popu- lation. 1844 and 1845 were only remarkable in one particular. Our town, in common with the country, suffered greatly from an ery- sipelatous fever, or what is ordinarily known as " black tongue." The mortality among the aged, the infirm, children, and the intempe- rate, was very great. This disease prevailed in the winter and early spring. In 1846,1847, and 1848, there was nothing worthy of note. In 1846-7, there was a great deal of tonsillitis, pharyngitis, and such like afflictions. The ordinary fevers of the country have progress- ively declined both in frequency and intensity since 1843. In 1848 and 1849, we had an epidemic of scarlatina. In 1849 and 1850, a great number of cases of cholera were brought, mostly by steamboats. The mortality was considerable, mostly among negroes. Our citizens suffered a good deal from choleraic diarrhoea, but none died. In the fall of 1850, typhoid fever first became manifest here, and has continued more or less up to this time, 1856. 1851. This year was healthy, with the exception of typhoid fever, diarrhoea, dysentery, and such like, until September, when in the course of a few days nearly our whole population (1000 to 1200) were prostrate with dengue. 1852. A very healthy year, with the exception of a few cases of typhoid fever, and a return, of dengue in the fall, when all had it who had not suffered from it in 1851. The Baptists held an asso- ciation here in the fall, and nearly every person who had not had the dengue previously, contracted it; but it did not develop itself until they returned to the country, and I never heard of an instance in which the disease was communicated (by those who contracted it here) to any person in the country. I will here make a few remarks about dengue. It has occurred to me that there is a close analogy between it and yellow fever. This is shown in the violence of the attack, it being a disease of but one paroxysm; the intensity of the pains, the general expres- sion of the patient, as red, wild eyes; flushed face, &c., and what attracted my attention particularly, was the hemorrhagic tendency, 78 especially among the females. In nearly all the females I treated, they suffered more or less on the subsidence of the disease from uterine hemorrhage. 1853. A few cases of typhoid, and hardly any other fever of any kind. On the 5th September, three gentlemen visited this place; two of them were from Galveston, and one from Harris- burg. They had been out from home ten days, and had left on account of the yellow fever, which was making great havoc in Galveston and Houston. They were all attacked at the hotel about the same time, of what I have no hesitancy in pronouncing yellow fever. They recovered soon, and the disease was not communicated to any person in the hotel. On the 27th September I was called to sec Mr. H., an English- man, at 12 o'clock M. I found him profoundly comatose, breath- ing natural, pulse about 100 and weak, head and body hot, ex- tremities quite cool, and bathed in cool perspiration. His wife informed me that he had complained for two days of great pains in his head and back; that on the day before I was called in he had gone out and finished a job; but that he complained very much when he returned at night, took no supper, slept little or none, but rose in the morning early; brought a bucket of water, seemed to be exhausted, fell down on the bed, and soon became quiet, and when she tried to get him to take some breakfast, she found him insensible. I found that our Episcopal minister had been with him some hours before I was called. We did everything we could for him, but did not succeed in getting him out of the comatose state in which I found him until next morning, when he sat up in bed and talked rationally for three or four hours, when he relapsed into a comatose state, and died about 6 P. M. After death he was the yellowest cadaver I ever saw. He had lived in the suburbs of the town, and hardly ever went out anywhere, but to his work and back home again; was a man of good habits, had been a resident of our place two years, and was uniformly healthy. Now, did this man contract the disease (if it was yellow fever that he died of) from an Englishman, Mr. B., and his wife, who told me that they both had had the dis- ease in New Orleans a month or six weeks before Mr. H. was at- tacked ? They came to Mr. H.'s house with some of their baggage, and occupied the same room with Mr. H. and family, eight or ten days before Mr. 11. was attacked. After the death of Mr. II., his 79 widow and two children had a mild attack of a continued form of fever, but the disease spread no farther in this quarter, notwith- standing from two to half-a-dozen persons were constantly with the poor man, from the time I was called to him until he was buried. October 1st, I was called to Mr. N. He occupied the first story of a brick house, the floor of which is laid on the ground. He used the room (say 50 by 25 feet), for a billiard and drinking saloon. Those who drank spirits at his bar were in the habit of tossing out spirits or water, &c., on the floor; this kept the earth under the floor constantly saturated with the refuse from his bar. He was in the habit of receiving ice every week from Houston, and of keeping it in his bar-room. It was moreover his custom to sleep during the day and sit up the principal part of the night; during the night the house was almost constantly closed, during which he breathed over and over again the noxious exhalations from beneath the floor, to say nothing of the deterioration the air of the room underwent from being crowded with a great number of persons drinking, smoking, &c. But to the case. He had a severe ague before I saw him, and was reacting when I reached him; was de- lirious; face very much flushed; eyes red and watery; pulse 110, strong and full; tongue moist, coated as with white paste: great irritability of the stomach. Suffice it to say, I treated him promptly; gave him the usual treatment for yellow fever, and had him in a good general perspiration in four hours; that he was almost without fever from the third day, and by the fifth had some return of appetite. But his nurse neglected him; a norther sprang up, he got chilled and relapsed, and came very near dying, but finally got well. Although he had not the least evidence of ptyal- ism, he had considerable hemorrhage from his gums, nose, and the blistered surfaces. Did he contract the disease from the blankets, sawdust, &c., in which the ice was enveloped ? We had no other cases in town this fall. 1854. This year, with the exception of typhoid fever, and some other affections not worthy of note, was very healthy until the 5th of October, when I was called in consultation with Dr. Black to see Mr. 0. He had unmistakable symptoms of yellow fever. He died on the fifth day with black vomit, and became very yellow after death. Before death he had hemorrhages from his gums, nose, and a blister over the epigastrium. He had not been to Houston or any other place where the disease was then prevailing, for several months. 80 10th October, I had two cases, Mr. L. and Mr. J. They both occupied the same part of the town in which Mr. G. passed most of his time during the day, and often until bedtime, viz., the house of Austin and Bertrand, a brick house, with a brick wareroom back, and immediately adjoining the building. The wareroom was at the time in a very leaky and filthy condition; not only so, but an extensive foundation was made but a short time before, for two large brick houses immediately adjoining the house of Austin and Bertrand. In digging out the foundation, a large quantity of earth was thrown out, it being about three feet to clay. The lot having laid vacant for eighteen or twenty years, and being about the centre of the town, and situated between two of the largest business houses in the place, it is but reasonable that a great quantity of impurities of one kind or other had percolated through the sand to the clay, and that when exposed those noxious exhalations from the earth would contaminate the atmosphere for some distance around. Be this as it may, at this spot the three first cases occurred. October 17th, I was called to one case from Houston. I treated the case in the suburbs of the town ; no member of the family nor any person that waited on the patient contracted the disease. Mr. B. contracted the disease here, and left for the West, and died on the fourth day of his illness, with black vomit. 30th October, one case. November 5th, three cases, two mulat- toes and one negro. These cases occurred within twenty feet of Asutin and Bertrand's wareroom. 6th, our postmaster was at- tacked. 7th, his assistant; also Mrs. S. 8th, three cases. 10th, one case. 12th, norther; temperature 30°.-Of the above four died and three had black vomit. I will bring this paper, which is already too long, to a close. But before doing so, I will state that yellow fever has prevailed more or less almost every year since 1839, in Houston; that our intercourse both by mail and otherwise has been almost daily, and that although we have had cases brought into our midst, repeatedly, the disease has never spread. Secondly; that as intermitting, re- mitting, and such affections have become less common, diseases entirely different from them have apparently come in their stead. Thirdly; that fevers identically the same that we suffered so much of, from 1837 until 1844, are very common within a few miles of this town, where persons are felling the forest and making farms, either in the Brazos bottoms, or in hammock land. Fourthly; that dengue did not prevail in any of the towns near this, in 1851 and 81 1852, although the places have all been built during the last nine or ten years; and in all of them they suffer considerably yet from the ordinary fevers of the country. Then, is it not a fact, that in countries where the ordinary mias- matic fevers prevail to any considerable extent, just in proportion as men remove the influences that give rise to them, typhoid fever, dengue, and yellow fever become more common ? In other words, that the causes of what are known as miasmatic fevers lie latent in our forests, &c., and man, in reducing the forest to a state of culti- vation, renders those causes active; and after a few years those causes are either decomposed or dissipated by the direct rays of the sun, or swept away by the rain. Then, is it not reasonable, judging by the facts we have before us, that through the agency of man, causes are generated or developed which, when in sufficient con- centration, will produce dengue, and typhoid fever, or when still more multiplied, will cause that great scourge of our country yellow fever ? Yours respectfully, T. J. HEARD. IX.- Yellow Fever at Jeanerrett's, Parish of St. Mary, La. By J. B. Dungan, M. D. I was called on the 7th of October, 1854, to the house of Leon Erilot, f. m. c., five miles below New Iberia, to see a Jew peddler, Lazare Levi, unacclimated, eight months in the country. He was lying in a room at the north end of the back gallery. Had spent four days in Franklin; whilst in Franklin, had visited several times at the house of Solomon Levi, in whose family several cases of yellow fever had occurred, and one or two deaths. Came to Leon Frilot's on the 3d of October, was taken with fever on the morning of the 4th, and died on the 9th, of black vomit. His cart had not been to Franklin, but was standing, previous to and during his illness, near the house. The goods in the cart had been bought (I was told) at some country store above St. Martins- ville. He brought no goods from Franklin. Immediately after his death the body was taken off for burial; the bed and bedding were burned; every article of furniture taken out of doors, the room washed, whitewashed, lime sprinkled on the floor, and left open and unoccupied for five or six weeks. A trunk of clothes belonging to Honore, f. m. c., was under the bed during the illness of the peddler; after his death it was carried out, 82 opened and exposed to the sun for a few hours, and was then de- posited in a room on the opposite or south end of the gallery, an open space intervening between the two rooms. No case of sickness occurred in the family until the 29th of Oc- tober, when I was called to see the wife of Alfred Olivier, f. m. c. This young woman was living in the family, but as soon as the peddler's case was pronounced yellow fever, she left the house and did not return until the 26th. She was taken sick on the 29th, had mild yellow fever, and recovered. On the 30th, the wife of Leon Frilot sickened; had black vomit, and died on the 12th day of her illness. On the same day, Leon sent his children with a negro boy about 12 years old to the house of his brother Aimd, about a mile distant on the opposite side of the Teche. On the 31st, his daughter, aged 13, and the little negro boy, sickened with the fever. The former died on the third day with black vomit, and the latter recovered. No cases of the fever occurred in Aime's family. Between the 1st and 22d of November eight or ten cases of the fever occurred among the free mulattoes at the house of Leon Frilot, and among the slaves belonging to the plantation, all of whom re- covered, with the exception of Honore, f. m. c., the owner of the trunk above alluded to. Being absent myself, this man was seen on the 11th of Novem- ber by Dr. Duperier, who considered the case one of yellow fever. I saw him after his death, on the 13th, at 9 P. M., and was shown about two quarts of bright florid blood which he had vomited shortly before his death. This man was intemperate, though pre- viously enjoying good health; he was walking about most of the time until a few hours previous to his death, frequently throwing up blood. Whether he died of yellow fever or not I cannot say. The last case of fever that occurred on the place assumed an in- termittent form. Dr. Duperier, who attended these cases in conjunction with my- self, and during my absence of several days, had the fever and recovered. Dr. Maguire called once to see the peddler, and again for a few minutes to see the cases of the free mulattoes. He was attacked on the same evening of the last visit, and after a serious illness re- covered. The writer escaped, although he has never had yellow fever. As to the locality in which these cases occurred, the house is 83 situated on a high, dry, and airy locality, on the west bank of the Teche, and disconnected with any other buildings except the kitchen, which is within a few feet of the house. There were no local causes assignable for the origin and spread of the disease. The house, although old, is comfortable and airy, and the family as neat and cleanly in their habits as whites in the same circumstances. The negro quarter is situated about fifty rods from the house, and contained twelve or fifteen head of negroes. The surrounding plantations were remarkably healthy during the prevalence of the epidemic on that place. Some cases of what the physicians called dengue had occurred at New Iberia, previously to the outburst of yellow fever on this place, but they were probably mild cases of yellow fever. But, so far as I could learn, this family had had no communication with that place. I furnish the above facts without any comment. P. S. The second case (Alfred Olivier's wife), during her ab- sence from Leon's house, passed the time with one of the neighbors, and had no communication with any suspected locality. X.- Yellow Fever at Brandon, Mississippi, in 1853 and 1854. By J. J. Thornton, M. D. [The following interesting letter will show how this disease broke out and prevailed at a village of about one thousand inhabitants, situated far in the interior of the country, and in a high piny- woods region. Dr. Thornton seems to think it attributable chiefly to local influences, though he admits that some of the first cases had been exposed in an infected district. A long and interesting ac- count of this epidemic was published in the Brandon Republican, by Dr. W. Reber, in which the writer takes somewhat different grounds from Dr. Thornton. He admits the existence of extraordinary local conditions in Brandon when the epidemic appeared, but, at the same time, thinks much is due to intercourse with infected dis- tricts.-E. D. F.] Brandon, Mi., Jan. 8th, 1855. Dr. E. D. Fenner- Dear Sir : I received your note and much valued present on last week, and, but for my engagements, should have replied sooner. I will now endeavor to give you a brief history, as you have re- 84 quested, of the fever of both 1853 and 1854. The first case that ever was seen in this place was R. L., get. 20, a native of this State. He visited Jackson, as conductor on the cars, a week previous to taking the fever, which was on the 15th of September, 1853; had black vomit and turned yellow, and died on the seventh day of sickness. Quite a number of persons visited him and many lived in the same house and nursed him, yet there were no cases traceable to this as an infecting cause. Case 2. A negro, aged 30, taken Sept. 20th, discharged 27th; eyes very yellow. Three others were sleeping in the same room, but no other case occurred in the house, which is distant from the residence of the first case three hundred yards, one dwelling be- tween. Case 3. D. E., aged 19, native of the State, taken Sept. 26th, dis- charged Oct. 4th, though he was several weeks in regaining his strength. Case 4. J. S., aged 17, taken Oct. 3d; came here two weeks pre- viously from Jackson; died on the 8th. He had black vomit, and had large black discharges from the bowels; eyes were a little yellow, skin not, but congested at the clavicles. This case had no communication with either of the others. A negro boy was sick with intermittent fever in the same room and nursed him, but had no symptoms of yellow fever. Case 5. Dr. J. H. B., aged 29, taken Oct. 20th, died on the 26th. He had vomit of reddish flakes and turned yellow. Case 6. G. Me., aged 31, taken 23d, well on 31st. In same house with fifth case. Case 7. C. V., aged 24, taken 26th, well in twelve days. In same house with two last cases; had nursed both; hemorrhage from gums and lips. Several whites and negroes nursed these cases; none were sick. Case 8. E. M., taken Oct. 24th, died on seventh day; was very yellow, and had black vomit. This patient was a native of Virginia; here twelve months; had not been to see any sick; was temperate and robust. Case 9. E. S., aged 50; taken Nov. 2d; turned yellow second day; had hemorrhage from gums; died the 7th; had black vomit. This man, a blacksmith, did not work within half a mile of any of the above cases, nor had he visited one; he slept out of town, and was temperate, not even using tobacco. Case 10. H. G., taken Nov. 4th; worked in the same house with 85 the above; wheelwright by trade. The shop was on the cut of the railroad, and there had been put near the shop, two years or more before, a great deal of sand from the cut. This sand washed down into a pond at the foot of the hill after every rain. The pond is some hundred and fifty yards west of the shop. H. G. lived ad- joining the shop on the east. He died on the seventh or eighth day of illness; was yellow. No other case occurred in the house or shop, although five others were exposed. Case 11. W. S., aged 18, taken about this time. He slept in the same bed that E. M. (Case 8) was taken sick in, who had been re- moved to a distant part of the town when he died, no other case occurring there afterwards. W. S. was removed also from the store to the east of the town, and died on the sixth or seventh day with black vomit. One case occurred in the house, but recovered. This was the proprietor of the store where the two clerks (E. M. and W. S.) were taken, who spent most of the day there, sleeping at the house. Quite a large family lived in the house, but none took the disease, though many more were in the room than the proprietor, who did have it lightly. There were other cases, but nothing either in type or locality to call for a description. In 1851 there were considerable changes made in the whole surface of our streets and many lots. A cut through the town, sixty-five feet deep and a quarter of a mile long, furnished dirt to fill up all washed places and to level streets, even to fill up valleys. The banks of the cut, as well as the dirt taken from it, have been constantly washing out and offering a new face at each rain. The cut is on the south of all the fever cases, but where they occurred there had been a deposit from the cut or a removal of the top soil. 1854. We had one of the healthiest summers and falls, till the first of October, 1854, that has ever been known in this town, and it remained healthy in the country around to the close of the year. We had a good deal of rain in the months of May and June, though not longer than a day and night at a time, soon drying up when the sun came out. The summer was not exceedingly hot, the ther- mometer not often getting as high as 90° in the shade. In August, the winds set in from the east and remained from that quarter most of the time till the middle of November, when north and west winds prevailed. The first case of yellow fever that occurred this year was a mile and a half southwest of town-taken about Sept. 23d, died on the ninth day of sickness, had black vomit two days 86 before he died; was very yellow-but, as his symptoms had been very mild for the first few days, and not being able to trace him to any place where fever had made its appearance, and as no case had yet been in Brandon-I for one was of the opinion that it was an aggravated, or perhaps mismanaged case of bilious remittent fever; no other case occurred at the plantation. There were some twenty on the place, black and white; some four or five acted as nurses; he was also visited by a good many persons, and not one took the fever. Case 2. W. B., aged 27; late from Michigan, taken sick Oct. 2d in Vicksburg, on his way to this place; arrived Tuesday; died on the sixth or seventh day of sickness. Oct. 3d. Numerous cases now occurred, and chiefly in the north and west part of the town, where the dwellings were much crowded for a village. H. V. S. was taken, and, in quick succession, six other cases in the same house, two of which died. One had black vomit; nearly all got yellow, and had hemorrhage from some part of the mucous membrane. The next house on the west had three light cases, two whites. A negro man was removed half a mile south; also recovered. The next house had four cases, three whites and a mulatto woman; all got well. The next house was north- west-had no case to originate in it, but I had a case moved there which died. No other in the house, although some eight or ten black and white were there till his death. No black vomit and no yellowness; yet as well-marked a case as I saw, in other respects. Had bleeding from gums, and his arm broke out afresh after my having bled him some eight hours previous. The next house north of this had three cases; all died. One, a relapse case, having had the disease the first or second week in October, relapsed two weeks after and died. He was thought by his physician to have had the fever last year (1853). I did not see him last year, but I saw his first attack this year, and did not be- lieve he had it. All the cases here mentioned were the most tem- perate and least exposed of our citizens, excepting the cases that came on a little before and at the same time with theirs. The next case was dissipated; had a light attack; was well in seven days. About this time, some ten or more negroes were attacked in and around the public square, the scene of extensive grading and filling, which is to the east of nearly all the cases; none of the negroes died, none had black vomit; some other cases came on about No- 87 vember, and lasted till the 17th or 18th. Some few died, but most recovered. The disease was confined to the region of town west and a little south of the grading, which has been extensive the past year, chiefly done in July and August. This, taken in connection with the vast railroad cut and exposure of the dirt taken from it, I think, furnish a local cause sufficient, without looking further. That it was not contagious I am satisfied, from these facts-whenever a case, taken in town, was removed to the country, or just out in the envi- rons, it was more liable to get well; and even if it died, no other case occurred either in the same house or neighborhood. Secondly, even in the locality where, I believe, it originated, no nurse or phy- sician took the fever; while, at the same time, those who lived here and slept here took the disease. Had it been infectious, there were goods just in from New Orleans, and being opened; yet no case occurred in those stores, and only one in any store, and that house purchased goods in New York. There was but one nurse who took the disease, and he was an Irishman who had been here some fifteen years, and slept in the district southwest of the Grading, at the head of a hollow which conducted the easterly wind freely into his bedroom. But one nurse had had the fever last year, and that one had symptoms of the disease again this year. A hue and cry was made about the cars running to town from Jackson, on the plea that they introduced the disease shut up in them; still, no railroad hand, clerk, or deputy took the disease at all till the disease was nearly gone from among us, and he, a negro, had been sick with chills, rode ten miles at night in the stage to see his wife, and sent for me next day. He then had yellow fever, and recovered on the seventh day. This case was sick in the house occupied by forty negroes, men, women, and children, not one of whom had ever had it, nor did one take it. My treatment was simple. In the outset, to open the bowels, which were usually costive; I gave oil, calomel, salts, or compound cathartic pill, either one. The stools were always the same, no matter which was used, dark, bilious, and fetid. Warm teas or cold drinks and ice; hot foot-baths, enemas, and sponging with hop-tea and brandy; blisters and the emulsion with creasote; for sick stomach, ale, brandy, champagne-in fact, the least treatment the better, only to keep the patient as comfortable as possible. Dear Sir: I have thus hastily tried to give a correct narrative of 88 facts, and given my views in few words. Time does not permit of my looking over this to make corrections of any kind. Take the above history for what it is worth; you, perhaps, can find and col- late the useful, if there be any. Respectfully, J. J. THORNTON. XI.- Yellow Fever at the Village of Cloutierville, La., in the years 1853 and 1854. By S. 0. Scruggs, M. D. [The following remarkable letter will doubtless be read with in- terest. It is to be regretted that the writer did not state more distinctly his method of giving the sulphate of iron in yellow fever before he began to prescribe the muriated tincture. The results of his heroic doses of the latter medicine are certainly very remark- able. I also received a letter from Dr. W. H. M'Craven, of Galveston, Texas, giving some very happy results obtained from the muriated tincture of iron in yellow fever, but do not feel fully authorized to publish it. Dr. Scruggs gives some striking facts, showing the transportability and infectiousness of yellow fever. The village of Cloutierville is situated on or near Red River, between Alexandria and Shreveport.-E. D. F.] Cloutierville, La., April 6, 1855. Dr. E. D. Fenner- Dear Sir : I have just reached home, and, in compliance with your request, hasten to give you the information you desired. The first case of yellow fever, out of the city of New Orleans, that occurred in the little village of Cloutierville, near which I reside, was on the 14th of August, 1853. I was called to it on the afternoon of the second day, and pronounced it, unhesitatingly, typhus; pre- dicating my opinion not only upon the symptoms presented, which were decidedly of that character, but from the fact that the case was in a room ten by fourteen feet square, in which eleven human beings (Germans, and not remarkably cleanly) were living, with but a small window and contracted portal to ventilate the meagre apart- ment. The next morning, without my knowledge, the patient was removed to the garret of the building, to be, as his friends informed me, a little more comfortable. I found him sitting up in bed, and asked him how he felt. He replied to me in German, as he spoke neither English nor French, that he was better as to his headache, but that he was very thirsty. Upon examination, I found his con- dition pretty much the same as the day before, only a greater degree of turgescence of the face. I left him, and returned on the next 89 morning at 10 o'clock, and found him extremely restless. I made the same inquiry, as to how he felt, as I had done the day before, but he made no reply. I placed my finger upon his pulse, but had scarcely touched it when, with a convulsive motion, he ejected a volume of black vomit over my entire person, which showed the more prominently from the fact that I was clad in white vest and pants. As a matter of course, it flashed upon me at once that my patient had the yellow fever, and not typhus, as I had diagnosed when I first saw him. Descending below, I made inquiry of his friends how long he had been from New Orleans, and was informed that it had been four months. This announcement staggered me for a moment, and without reflection, I concluded that it was sporadic. In the afternoon of the same day I returned to the house to ask how long it had been since their goods were opened, and by whom they were opened, and how long since the goods had been shipped from New Orleans; and was informed that my patient first opened them, assisted by Frank and Kohn, about ten days before, and that it had been fifteen days since the goods were packed in the city, and that the three who had gone down to purchase had each perished with yellow fever. My patient died shortly after I left the house, and knowing as I did how fearfully the epidemic was raging in your city, it occurred to me that the disease might have been brought up the country in those goods, although the contagion of yellow fever had been so often denied by those of the profession whose peculiar locations had given them ample opportunities of investigation. It was not long, however, before I became convinced that the disease had been imported in those goods, and that yellow fever was an in- fectious disease; and, before I conclude, I will present you the grounds upon which I predicate my opinion. Had no other case occurred but the one I have recorded, I should have regarded it simply in a sporadic light, and have thought but lit- tle more about it; but the disease, in a very short time, assumed a most malignant and desolating form. At the time that the first case occurred, there were ninety-one inhabitants of the town, but be- fore the disease abated sixty-eight died, the first three of whom were the very three who opened the boxes of goods but a few days before. Some twelve days after the death of the first case I fell myself, and was unable to perform any duty until the 2d of October, and, as a consequence, I am unable to tell you what took place during the time I was confined to my bed, more than that upwards of fifty 90 died. The epidemic continued in the surrounding country until the 14th of December. Now, as to its contagion, or rather infection. In the first place, Cloutierville is isolated in a very great degree, being located upon La Riviere aux Cannes, or Cane River, a portion of Red River, that is navigable for boats but a few months in the year, and particu- larly in the year 1853, there had not been a steamboat at her land- ing for more than six weeks. Now, is it probable that a disease like the yellow fever should have developed itself naturally in our midst, decimating the village and desolating the country, when not one of the causes of its production exists ? Why is it that this ill-fated little village has never been visited before by yellow fever, when nearly every other town where steamboats ply during the preva- lence of the disease in New Orleans has been attacked by it? The disease has visited Alexandria and Natchitoches more than once, and it is strange to me that they do not have it oftener, particularly Alexandria, where the steamboats are constantly landing. I cer- tainly know of no local cause for yellow fever in and about Clou- tierville. My plantation and that of Mr. A. Lecompt surrounds it, and neither of us have a lagoon or lake upon our respective places, nor is there a marsh in any direction contiguous to the vil- lage. Where, then, did the terrible disease have its origin in 1853, but in those identical goods ? How did it happen that the disease was confined at first to the very spot, and the only one from which we can fix a cause for its appearance ? And why is it that the first three who had it and died were the same three who were en- gaged in opening the goods purchased but ten or fifteen days before in the city of New Orleans, and in a store where all the inmates save one died, together with the three purchasers of the goods who resided in Cloutierville, and that, too, during the prevalence of the most fatal yellow fever epidemic with which your unfortunate city •was ever cursed? What does such evidence teach us? But, again, shortly after my recovery, I was upon a visit to a friend some twenty-five miles from my home, when I was requested by the physician of my friend's family to visit with him a case he had in the pine woods, a distance of about four miles, which, he said, presented some peculiar characteristics. I did so, and pronounced it yellow fever. As well as I now remember, the patient was a German peddler, and died the next day after I saw him, with black vomit. The family, at whose humble, but hospitable mansion the poor stranger had fallen a victim, consisted, I think, of five; four of 91 whom died within fourteen days of the German, and not another case occurred in the neighborhood. The German evidently contracted the disease in the town of Natchitoches. Now, sir, here we have black vomit occurring in the pine woods, in an individual who had been where the disease was raging; and an entire family destroyed by the same disease; yet neither of them had been within twenty miles of the disease in any direction, nor ever saw yellow fever until the poor peddler brought it in their midst. How did they get yellow fever? Why did not their neighbors have it ? Why, simply be- cause I proclaimed to all that the disease was infectious, and that by cutting off all communication we would be enabled, as Dr. Rush remarked in 1793, to " pen up the disease like a mad bull." Can any rational mind doubt for a moment that, if the poor German had never gone to that house, that the yellow fever would have ever desolated it ? The above instance, added to that of the goods in my own vil- lage, fortified my opinion that the disease was infectious, and had it not, two other circumstances which I will detail, were " confirmation strong As proofs of Holy Writ" that it was emphatically so. On the opposite side of Red River proper, commonly called the Bon Dien, a kind of neighborhood quarantine had been kept up in the pine woods, during the preva- lence of the epidemic in Cloutierville, and no one was allowed to pass within a certain distance of one of the houses? One of the neighbors whilst on guard met with a woodcutter who had been to Alexandria, but who said he had been for two days at the house of a gentleman some twelve miles distant. The man told him to go on to the house, that he would be on himself after awhile. That very night the wood-chopper was taken with a chill, and in five days died with black vomit. All the neighbors, believing that it was nothing more than a simple case of fever, as he had been no- where to catch the "black vomit," visited him, and, in twenty days afterwards, there was but one left among all who resided in the neighborhood to tell the tale of the fearful ravages of the dis- ease. The wood-chopper had been living there for years, and was working for them at the commencement of the epidemic at Clou- tierville. Now, how did the wood-chopper get the disease? Why 1 Nearly all who reside on that side of the river live by cutting and selling wood to the steamboats. 92 he caught it in Alexandria. Well, how did the Perkins neighbor- hood get it, if it was not conveyed there by the laborer above mentioned? It could not have been carried there in any other way. A German peddler died about twelve miles from me, early in the epidemic, and the room in which he died was immediately closed. Some days afterwards, some friends of the family who occupied the house, arrived from Texas, and rather than put them in the bed where the peddler died, a young man of the family took it himself, and in eleven days afterwards he died of black vomit, and several others in the family were very ill. Now, it is very true, this family were very poor and filthy, and the young man slept in the very bed in which the peddler died, without its having been changed; but does not this very fact go as additional evidence to prove that the disease is infectious? I could multiply instances, but it is unnecessary. I have given you what I know to be facts, not what I heard. I come now to speak of my treatment, but especially the iron treatment. Early in the fall of 1853, or at least it was after the epidemic had been raging for some time in your city, that I stated, in a letter addressed to my lamented relative of Shreveport, Dr. R. L. Scruggs, that if ever I found an opportunity to treat yellow fever, I would not hesitate as to the remedy, and that remedy would be the pure chrys. sulph. ferri, an article for whose use I am indebted to my old personal friend, Dr. Robert Gayle, of your city, not in yellow fever, however, but in enlarged spleen. The first case I visited after my recovery was that of a particular friend. At the house of this friend, I will here remark, en passant, there was a stranger sick with yellow fever, and who was being treated by a French physician. A servant was just coming out of the sick man's chamber with a vessel of blood. Upon inquiry, I found out that the stranger had then been bled for the fourth time. It is useless for me to say to you that he died, together with twenty-eight others, under the lancet practice of the scientific French doctor. I mention this merely from the fact, that seeing the blood from the arm of the stranger, whom curiosity prompted me to look at, in going out of the house, but settled my conviction as to the iron remedy. To my friend I administered the iron and departed to visit three other patients, to all of whom I gave the same prescription. The following morning I visited them all, and found them doing better 93 than I had any right to expect. I continued the iron and they all recovered. I did not lose a case after that out of upwards of forty. The following summer, 1854, the epidemic again made its ap- pearance in my neighborhood, but I was absent from home, and, unfortunately, had not here an opportunity of trying the relative value of the pure sulphate, and the mur. tinct. ferri which I greatly desired. During my voyage, however, I had a fine opportunity to test the tincture on board the steamboat upon which I ascended to St. Louis. The Mississippi was remarkably low and the boat heavily laden; and as a consequence, the trip up was a long and tedious one. Several cases of yellow fever occurred on board, all of which I treated with the tincture, and entirely successfully. My prescrip- tion was generally sixty minims every three hours, until eight doses were taken. Four days before my arrival at St. Louis, my servant, a very in- telligent fellow, took the disease. I prepared in a tumbler half an ounce of the tincture to four tablespoonfuls of water, giving him one dose only, intending to repeat it in the several periods of three hours; but being indisposed myself, I gave him my watch, stating to him that if I did not come in again in three hours he must take another tablespoonful of the mixture. I did not return but once, and that was too early for a repetition of the dose, but on my second visit, I found to my utter astonishment and alarm, that he had, instead of one tablespoonful, taken the entire quantity at one dose. I immediately asked him how long it had been since he took the potion; he replied "about an hour." I placed my finger upon his wrist, and found his skin moist, and his pulse, so far from an unusual excitement, had actually fallen from 121 to 102 during the interval of my last visit. In four hours more he had but little febrile excitement, and recovered rapidly. I would remark that he was very active in his attentions to the other cases which occurred on the boat during the voyage. This one isolated case proves one, if not two things, viz: that if the muriated tincture of iron is not a proper remedy in yellow fever, there is but little harm in the administration of it in heroic doses. Upon my return home, I was summoned as a witness in court, a distance of some thirty miles from my residence. Whilst there, a neighbor requested me to get permission from the judge, for a day only, that I might visit his hospital. I did so, paid the visit, and 94 found two griffe servants, as I believed at the time, beyond all hopes of recovery. I ordered, as a dernier resort (having the case of my servant as a precedent), the following heroic prescription: Tinct. ferri muriat. oij; aqua fontis ^yj; M. One ounce of which to be given to each every two hours. I left immediately, requesting my friend to inform me of the result of my medicine, intimating to him, at the same time, that when they died I would be pleased to examine them. Confined as I was as a witness in court, I did not hear from my patients for four days, when, to my utter astonishment, I learned that they were both recovering. They did and are now well, and working as usual with the other negroes. These last two cases are all that I treated so valiantly, and whether they recovered in spite of my physic, or by its potential influence, the Omniscient only knows. Did you remark a peculiarity in regard to females, that, so soon as the attack came on, the menses made their appearance also, al- though they may have just passed naturally? In nearly every instance, up here, such was the fact. May this circumstance, from the peculiar condition in which the blood of yellow fever is always found, not throw some light upon the long vexed question of the menstrual discharge? I hope I shall hear from you soon. There is a circumstance (which, I think, deserves a passing notice) connected with the two epidemics of this region of country, that is certainly somewhat singular. Above me, about six miles, there is a large population of free colored people. During 1853 not one of them had yellow fever. Yet in 1854 the disease was confined almost entirely to them, and but one white person died, or even had it, who resided in the neighborhood, and who did not have it during the prevalence of the epidemic. I have thus, sir, in a rapid and hurried manner, complied with your request. Hoping that the inaccuracies consequent upon hur- ried composition may receive a charitable consideration at your hands, I remain Yours, truly, SAMUEL 0. SCRUGGS. 95 [The subjoined sketch of the yellow fever at Norfolk and Ports- mouth was received in connection with the previous papers of the Appendix, and although it forms no part of the Eeport presented by Dr. Fenner to the Association, yet its interest and value will, in the opinion of the Committee, be regarded as an adequate reason for introducing it in this place.-Com. of Pub.] ON THE YELLOW FEVER OF NORFOLK AND PORTSMOUTH, VA.1 BY E. D. FENNER, M. D. Some of your readers may be at a loss to discover an object suffi- cient to induce a practising physician of New Orleans to leave his own city, in the midst of an epidemic, and go abroad in search of a disease which for some years past has committed such dreadful havoc among the people of his immediate vicinity; and the same in respect to others, both acclimated and unacclimated, who, on hearing the cry of alarm and distress that went forth from Norfolk and Portsmouth, went not only from places where yellow fever is a common disease, but from many others, where it is either unknown, or has not prevailed in their day. I will endeavor to satisfy these searchers into human motives, for I deem the inquiry a very natu- ral one. I will 'say, then, that some were employed for the purpose and liberally compensated by their benevolent fellow-citizens at home. These were selected for their capacity and experience. Others, like- wise experienced and acclimated, hastened to the scene of distress, and cheerfully volunteered their services to the sufferers of every class. Whilst others, of bolder daring still, who had never either seen or suffered the disease, rushed into the midst of the pestilence, and, reckless of personal danger, begged the privilege of doing whatever they could to relieve their dying fellow-beings. How this latter class sacrificed themselves in the cause of suffering humanity, and how the others performed the duties assigned to or assumed by them, is not for me, but for the surviving citizens of Norfolk and Portsmouth, to say. Such, at least, were the leading motives, as far as I could judge, of the physicians from abroad who visited these places in the late epidemic. For myself, besides a desire to do some good, if it were in my power, I wished to see yellow fever at a dif- ferent place from New Orleans, where I had observed it closely for the last fourteen summers; and, as I remained at home until our 1 From the New Orleans Medical and Surgical Journal, November, 1855. 96 epidemic had reached its maximum, I knew that my services could well be spared for the rest of the season. It is not my purpose, on the present occasion, to attempt to fur- nish you a full account of this epidemic, but only to make a few remarks upon some of its more prominent features and incidents. Long before reaching Portsmouth and Norfolk, we met the most frightful rumors of their sufferings, and when we arrived there ap- peared to be but little exaggeration in these flying reports. The stores were all closed, all the workshops were silenced, and the only appearance of activity visible was in the hurried movement of physicians' vehicles, and of persons in pursuit of medical aid and comforts for the sick. It was thought that more than half of the inhabitants of both places had fled from the impending danger, and I was truly glad to hear it, for I am well convinced that in occa- sional outbreaks of yellow fever the greatest safety will be found in flying from the infected district. In this instance, nearly all that remained were in continued apprehension of attack, for there were probably not a dozen persons in both places who were secure by having had the disease previously. Many had occasion to regret that they did not make an early retreat, and some went too late; they were attacked in other places, and, almost without an excep- tion, fell victims. When Dr. Beard and I arrived at Norfolk, we found the epidemic raging with terrific violence, and increasing from day to day. Some of the resident physicians were already down with the fever, two or three had died, and the rest were doing more labor than human nature could stand for any great length of time. Not a single one of them was acclimated, and therefore they all expected to be at- tacked sooner or later. Yet they stood their ground like true heroes, resolved to stand or fall at the post of duty. What rendered the case of these gentlemen worthy of more special sympathy and ad- miration was the fact that their devoted wives could not be per- suaded to leave them, but determined to remain and share their danger. How great these dangers were, may be learned from the fact that more than two-thirds of the resident physicians have fallen victims, and the others have narrowly escaped with their lives. At the time of our arrival, it was impossible for the medical force in attendance to do justice to the sick, and the disease was spreading so rapidly that the heart sickens at the contemplation of the state of things that must have come about, but for the valuable aid of 97 various kinds that came pouring in from almost every section of the Union. But for these immense contributions in the way of money, provisions, physicians, nurses, medicines, coffins, &c., the citizens would, soon have been unable to attend their sick and bury their dead, and all who were able would have been compelled to fly away and leave their city in sole possession of putrefying corpses. Even with the assistance that came, it was found, difficult at one time to get the dead buried., and a few corpses remained out of the ground as long as thirty-six or forty-eight hours. When we got there we found one New Orleans physician, Dr. Penniston, already on the ground and doing immense labor. Dr. Stone had been there, but was only able to remain a few days. In a short time we had an ample medical corps, consisting of physicians from New Orleans, Mobile, Charleston, Savannah, Philadelphia, Baltimore, Richmond, and sundry other places, who, in connection with the resident physicians still moving, were able to visit the sick as often as necessary. Nurses, too, came from all the places first mentioned, and others, some of whom unfortunately were but illy prepared to meet the danger they voluntarily encountered. Like the unacclimated physicians, many of them suffered severely from the epidemic, and some fell victims. At one time New Orleans had fifty nurses in Norfolk and Portsmouth, employed at the rate of sixty dollars a month; and Charleston sent forty, at forty dollars a month. My own observations were confined to the city of Norfolk, with the exception of a single visit to the U. S. Naval Hospital at Ports- mouth, a magnificent establishment in charge of surgeon Minor, which, by order of Government, was opened for the general admis- sion of yellow fever patients. There I saw some forty or fifty pa- tients in different stages of the disease. A temporary hospital had been established some three or four miles from Norfolk, but it was found to be too inconvenient of access. The new Howard Infirmary, established in the heart of the city after our arrival, was found to be very serviceable. The impression made on my mind by the first cases I saw of this epidemic, was that it was of a mild type, and ought not to prove very fatal if properly managed. Indeed, the first seven or eight cases I took charge of, yielded very readily to a mild course of treatment; but it was not long before I discovered that the tendency to death in apparently mild cases, or those marked by no violent symptoms whatever, was much stronger than I had supposed. In some of the cases the approach of the disease was very gentle, there 98 being nothing observable but a sense of fatigue, little headache, and slight feverishness. Indeed, the person would be in doubt whether he had the disease or not, and perhaps send for a physician to decide the question for him. A few hours would be sufficient to settle it, and he would then go on with symptoms somewhat better marked, but still not at all distressing. If asked how he felt, he generally replied "pretty well," or "very welN The system appeared to re- spond readily to moderate doses of medicine; every function seemed to be going on well, and the prognosis would be thought favorable until the approach of the critical period, the end of the third day. Then, if the case were going to terminate badly, there would appear eructations and acidity of the stomach, suppression of the urine, slight delirium and restlessness, and the patient would go into fatal black vomit and coma, in spite of anything that could be done for him. This unfavorable change would often take place most un- expectedly, and without the commission of any imprudence what- ever. Such were the cases of Mr. Cunningham, editor of the Nor- folk Beacon, and Mr. W. D. Roberts, a member elect of the Virginia Legislature. Each of them had mild attacks, and went on as quietly as possible for yellow fever patients till the close of the third day, when suppression of urine and other fatal symptoms appeared, and they sunk unconscious and almost without a struggle. Mr. R. threw up black vomit copiously. They were each about fifty years of age, and it was a remarkable fact, that but few persons of this age or be- yond, recovered from this epidemic. In many of these mild attacks, the skin acted finely till the third day, when it would become dry, and very soon be followed by rest- lessness and other bad symptoms; in others it was difficult to keep up a steady perspiration. The skin would not be very hot, nor was it difficult to start a perspiration, but it would soon cease, and there was a constant tendency to dryness. This symptom was generally unfavorable, but when accompanied by a loose state of the bowels, I regarded it as very much so. I have mentioned particularly these gentle attacks and apparently mild cases with the view to show the strong tendency to death that often existed when there were no urgent or distressing symptoms to give warning, thus too often blasting the fond hope and anticipation of physicians and friends; but it is not to be denied, that in the ma- jority of cases, the attack was open and bold enough, yet not suf- ficiently so to demand the use of cups or the lancet as often as we see in New Orleans. 99 The disease appeared to become more malignant as the season advanced, as was shown by the greater number of deaths in propor- tion to attacks, and this was observed up to about the 27th of Sep- tember, when the epidemic rather suddenly declined, without the appearance of frost or storm, or any extraordinary change in the weather. Such, you know, was the case in our great epidemic of 1853. I have often been asked the question whether in Norfolk the epi- demic was not more malignant and in other respects different from any that has prevailed in New Orleans. In reply, I could not say that it was. I saw no peculiar symptom or variety of the disease that I had not often witnessed in New Orleans; yet there may have been a difference in the relative frequency or combination of certain symptoms which would characterize this epidemic as being some- what different from all others, inasmuch as we never see two epi- demics precisely alike, even in the same locality. The malignancy of an epidemic is generally estimated by the mortality it causes; and in this respect a search into the records of yellow fever will show that the late mortality at Norfolk and Portsmouth, although very great, does not stand unrivalled. An estimate of this, however, can only be formed after we obtain a report of the number of persons exposed to the disease, the number attacked, and the total deaths, for which we will have to look to the physicians and authorities of Norfolk and Portsmouth. Let us now take a glance at some of the more prominent features of this memorable epidemic. It is well known that suppression of urine is a symptom of not unfrequent occurrence in yellow fever, and is generally considered a very bad symptom. I think it was more common in this epidemic than any I have ever witnessed, and was always of very serious import. In some few instances the secretion of urine was restored after being reduced to an exceedingly small quantity for twenty- four hours or longer, but where there was a total suppression for this length of time, I believe it was as rare to witness recovery as from the worst form of black vomit. Nor am I aware of anything that can be confidently relied on to restore this function when com- pletely suspended. I have known the flow of urine to be increased after having been reduced very low, and always viewed it as a favorable omen, but am by no means sure that the beneficial ch ange was justly due to the use of turpentine, nitre, gin, or any other 100 diuretic. I am not inclined to believe that the suppression arises from any material change in the substance of the kidneys; none at least has been as yet satisfactorily demonstrated by post-mortem examinations. It seems to me that it must depend upon the morbid condition of the blood and the nervous system. Be it as it may, this symptom was certainly much more common at Norfolk than in the great epidemic of 1853 at New Orleans. In respect to hemorrhages, the grand characteristic feature of yel- low fever, almost every variety was witnessed at Norfolk, such as from the nose, mouth, stomach, bowels, uterus, scrotum, blistered surfaces, &c. In accordance with my observation at New Orleans, these hemorrhages were of different import, according to their seat. When hemorrhage began at the nose, gums, or uterus, it appeared to be a critical discharge, and was most generally followed by a salutary change in the condition of the patient; but when it began at the stomach, it made what is generally known as black vomit, a symptom that still holds its long established position as one of the most dangerous that attends this terrible disease. Black vomit was exceedingly common in this epidemic, and, what is worthy of remark, there were numerous recoveries from it. I hardly con- versed with a single physician who did not tell me of having seen one or more recoveries from this usually fatal symptom. The day I left Norfolk and was coming up James Biver, I had the pleasure of falling in with an interesting young lady, about thirteen years of age, the daughter of Capt. Whittle, of the Navy, whom I had treated in the epidemic. She had thrown up black vomit for forty- eight hours, but recovered from it, and then stood before me in perfect health. Becovery from black vomit was most common to the youthful, but several instances were seen amongst persons of more advanced age. In some cases the attack was ushered in with bilious vomitings; otherwise the symptoms throughout were not of a violent character, yet the case was very apt to terminate fatally. Some writers con- tend, as you are aware, that bilious vomitings are never met with at the onset of yellow fever, but my observation teaches me differently. Some of the most obstinate cases of this epidemic were marked by an almost perfectly natural tongue. I met with several cases in which severe hunger was a prominent symptom. They were very apt to terminate fatally. 101 The negroes of Norfolk suffered severely from this epidemic, though not so much as the whites. The disease seemed to affect them pretty much as it does in Louisiana, and wherever there was any mixture of white blood amongst them, its effects were more severe. The bright mulatto will have yellow fever almost as severely as the pure white. From what I could learn, there were more deaths among the blacks of Norfolk than have ever occurred in an epidemic at New Orleans. Relapses were not unfrequent, and were generally dangerous. I knew several instances of second attack in persons who had had the disease previously at other places, but generally after intervals of ten or fifteen years, in which there had been no exposure to the disease. Nothing short of thorough acclimation afforded protection against this epidemic. In respect to treatment, I believe I have nothing new to offer, or anything that is worth inserting in your journal. Amongst so many physicians collected together from different places, and having views and opinions derived from such different sources, of course you would expect to find quite a variety of treatment. Such was the case at Norfolk. Of one thing I am pretty certain, the mortality was large under any treatment I saw pursued. Either the disease was unusually malignant or the constitutions of the people had less capacity for resisting its assaults. They seemed to sink more readily under its deleterious effects; to die with milder and less formidable looking symptoms than I ever witnessed before. Somehow or other the people of New Orleans make a better fight against yellow fever than did the citizens of Norfolk. It has been observed, how- ever, that whenever yellow fever epidemics prevail in more northern latitudes the mortality is very great. For myself, I recommended and used a mild course of treatment at Norfolk. I did not try to cut short and cure the disease, but rather to guide the patient through its natural stages. I thought I saw inj urious effects from over-medication, but it was notorious that the opposite or do-nothing system of the homoeopaths was signally unsuccessful; and then the survivors appeared to feel that their friends had been lost without a fair struggle against the destroying enemy. A remark or two about the mortality and supposed origin of this terrible epidemic must close this communication. Dr. N. 0. Whitehead, the acting Mayor of Norfolk, in a letter to the visiting physicians when they were about to depart to their 102 respective homes, at the close of the epidemic, estimates the average population of the place during the pestilence at about 6,000, and the number of deaths at 2,000. I think these estimates will prove to be somewhat erroneous, and that the number of deaths most probably did not exceed 1600. A complete census of the 3d ward was taken by the Relief Com- mittee, which furnished the following statistics:- Population-whites, 638; colored, 558; total, 1,196. Fever cases-whites, 579; colored, 213; total, 792, or two-thirds of the inhabitants. Deaths-whites, 159; colored, 13; total, 172, or 21.70 per cent, of the attacked. This is one of the largest wards in the city. The mortality at the new Howard Infirmary, and also at the U. S. Naval Hospital, was about 35 per cent., or 1 in 2.80 of the admissions. About 70 physicians and second course medical students went to the assistance of Norfolk and Portsmouth, of whom 21 died. I am not prepared to admit that this epidemic was at all more malignant than that of New Orleans in 1853, though the mortality may have been somewhat greater in proportion to the attacks, from the depressing influence of panic and the want of proper nursing, which was severely felt at the beginning. As for the origin of the epidemic, it must remain shrouded in doubt until all the facts and circumstances attending its commence- ment are fully reported. But two sources are looked to by common consent: it must have originated either from a local cause, in con- nection with a peculiar constitution of the atmosphere around, or from a morbific germ imported by the steamship Ben Franklin. That it may have originated from the former, would appear pro- bable, from the fact that three cases of yellow fever occurred last year in Norfolk, and at the very spot where the epidemic of that city commenced this year. This was the celebrated Barry's Row, which was burned down this year. These cases occurred late in the season, and were not traceable to any foreign connection. In 1852, there were also several well-marked cases of yellow fever in Nor- folk, likewise apparently of local origin. I was also informed that some cases very much like yellow fever, though perhaps not un- questionably, were observed this year simultaneously with the first cases on board the Ben Franklin. But, on the other hand, it is certainly true that the epidemic appeared to commence at the spot 103 where the Ben Franklin laid, which was at Gosport, and from there spread progressively over Portsmouth and Norfolk. Now, let us look to the behavior of the ship Ben Franklin. She arrived on the 6th of June from the island of St. Thomas; was exa- mined by the health officer, Dr. Gordon, on the 7th, and, although she was found to be perfectly clean and free from disease, she was ordered to undergo quarantine, because she had come from a sus- pected port. During her late voyage, two deaths had occurred on board; one a fireman, who died of disease of the heart, and the other a sailor, who was put in his place, and sank from exhaustion, being unaccustomed to the employment. On the 19th of June the vessel was released from quarantine, at the instance of the Board of Health of Norfolk, no case of sickness having occurred during her detention, notwithstanding the employment of a new crew on the day after her arrival. The vessel was then taken up to Gosport for repairs, and remained there until July 8, eighteen days after she had been released from quarantine, when the authorities of Ports- mouth ordered her off, on account of the occurrence of a case of yellow fever that was thought to be traceable to the vessel. She again returned to quarantine ground. On the 12th, she was exa- mined by Dr. Schoolfield, on behalf of the Portsmouth Common Council, and was found to be perfectly clean and healthy. On the 13th, these parties addressed a note to the health officer, stating these facts, and consenting to release the vessel from quarantine again. On this day Dr. Gordon visited her, and found a suspicious case of fever on board, which caused him to detain her till the mor- row. He then visited her again, and found two more cases, which he pronounced to be yellow fever. From that time and place the disease continued to spread till it resulted in the terrific epidemic that has caused such desolation in both cities. Such is a brief sum- mary of the facts relative to the ship Ben Franklin, obtained from authentic documents, and published by a correspondent of the Rich- mond Whig. Now, if three cases of yellow fever originated from local causes at Norfolk in 1854, and a greater number of cases in like manner in 1852; and, furthermore, if one or more cases were seen about Norfolk and Gosport at the time or previous to the first case that occurred on the Ben Franklin, and having no connection with that vessel, as I heard reported, there is certainly much room to doubt whether this epidemic arose from an imported infection. It is hoped that all the facts attending the origin of this memo- rable epidemic will be authentically reported at an early day. 104 There is one important point, on which, I believe, there is a general concurrence of testimony, which is, that this disease was neither contagious nor infectious beyond the limits of Norfolk and Portsmouth. Numerous cases were carried to Baltimore, Richmond, Petersburg, and various other places, and in not a single instance was it communicated to persons coming in contact.