Glucagon Opioids Vasopressin (VP) SRIF LH, FSH, TSH Angiotensin Il ACTH. ACh (M) Epinephrine (f's) Epinephrine (5) Fig. 6: 1984 model of adenylyl cyclase susceptible to both stimulatory and inhibitory regulation through the respective heterotrimeric stimulatory (N,, now G,) and inhibitory (N; now Gj) regulatory components. Each G protein was shown to be under the control of a distinct set of receptors responsible for distinct hormonal specificities exhibited by adenylyl cyclases from different tissues and cells. (From Hildebrandt et al. 1984)