|<— LIPID =| ae ‘ ‘ 1 ; i DISCRIMF/, ' > TRANS ' HORMONE D>, ror \i ANSDUCER \ AMPLIFIER i ; . cyc AMP /K——— PLASMA MEMBRANE ———>| outside inside Fig. 3: Early 1970 representation of the hormone sensitive adenylyl cyclase as a system formed of three functional elements: discriminator, transducer and amplifier. (From Rodbell et al., 1970b)