Glucagon TSH ACTH LH Epinephrine

 

 

 

 

 

 

 

 

 

 

Adeny/ Cyclase

 

 

F----|-->Mgtt

~~

Mg-ATP cyclic-AMP

 

 

 

Fig. 2: 1969 conceptualization of an adenylyl cyclase system stimulated by
multiple hormones. Receptors were thought to be separate of adenylyl cyclase
and of having two domains: a distinct ligand binding domain responsible for
specificity of interaction and a common the adenylyl cyclase domain allowing
all to interact with a common enzyme. (From Rodbell et al. , L970b).