NATIONAL RESEARCH COUNCIL NATIONAL ACADEMY OF SCIENCES NATIONAL ACADEMY OF ENGINEERING 2101 CONSTITUTION AVENUE WASHINGTON, D.C. 20418 INSTITUTE OF LABORATORY ANIMAL RESOURCES TELEPHONE: 202-961-1692 DIVISION OF BIOLOGY AND AGRICULTURE March 20, 1970 Dr. Joshua Lederberg Department of Genetics Stanford University School of Medicine Stanford Medical Center 300 Pasteur Drive Palo Alto, California Dear Dr. Lederberg, This is in response to your letter of March 11th requesting information on animal models for gluten enteropathy (celiac disease, Cine of sprue) and drug“induced aplastic anemia. he evidence {ase few. enteropathy I am aware of St ata of is dogs. el is: Malabsorption syndrome resembling nontropical aneko, J. J., et al. J.A.V.M.A. 146:463-473 (1965). The only model of A reference for thi sprue in dogs. oly ata on Animal Models in the study of gastrointestinal diseases of man. Gastro- An additional reference which you may be interested in is: Symposium O enterology 53:107-123 (1967). a With regards to models for drug-induced aplastic anemia, we may be better D able to assist you if you indicate what group(s) of drugs you are interested in. I hope the former information is useful. Sincerely, orange Cece D. oférioy D.V.M. Staff Officer CO) N20 Bw “yer - a vArhere veoplareed ; benzene; Am nepyrnnt _