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STANFORD UNIVERSITY \ ebicar CENTER (e4f%
STANFORD, CALIFORNIA 94505

 

 

 

December 9, 1974

STANFORD UNIVERSITY SCHOOL OF MEDICINE

Department of Genetics
(415) 497-5052

Dr. Jakob Nilesch
Ciba-Geigy AG
CH-4002 Basel
SWITZERLAND

Dear Dr. Nulesch,

Thank you for your letter of November 25th. I appreciate your
taking the trouble to lock into the question of agarase, I had not been
aware of the Calbiochem prep and we will certainly test it.

I am glad to see that you are keeping your eyes open for literature
in genetic engineering. The author of the reference you mentioned was kind
enough to send me a copy. I am also sending you something that I may or
may not already have given you. I am delighted to see that some attention
is being given towards trying to get practical applications from the
theoretical research of the last three decades,

With respect to Dr. Lebet, he certainly does come with formidable
credentials. Yes, in view of the financial situation here it would be
almost indispensable for him to have his ow funding with respect to
Salary and travel. My own laboratory is preoccupied with the fractionation
DNA from bacteria, the rejoining of DNA molecules, and the genetic
consequences of their reinsertion into bacteria. This does involve a
considerable bridging of biochemical and biological expertise and I do
not know if it conforms to the list of interests that you mentioned for
Dr. Lebet. Certainly, there are some laboratoties in Dr. Kornberg's
department that might be a closer fit. Please advise me if you had in‘
mind that we should consider him as a prospect for my own laboratory -
which is rather more biologically oriented — or whether I should concentrate
on bringing this material to the attention of Dr. Kornberg or Dr. Hogness
who are more immediately preoccupied with problems of membranes and of
regulation of synthesis, With his excellent rerommendations I should think
that he would have some choice about where he might be accepted, so I think
it is important that his preferences be clearly stated before proceeding
further,

Sincerely yours,

 
   

Ror Cogas atpeo- trl ym | oshua Lederberg
ho Vit fo D of 4 Professor of Genetic

, An aelN.AAs

MA outing! Urdrertnand a
Enclosure

LT. J. bo KENNEDY, JR. LARORATORIES R MOLECULAR MEDICINE, DEDICATED TO RESEARCH IN MYNTAL RETARDATION

MOLECULAR BIOLOGY HEREDITY NEUROSiOLOGY DEVELOPMENTAL MEDICINE

Se
Agar-Decomposition and "Agarase"

 

Agarase producers: Bacillus gelaticus
Agarbacterium sp. (Bergey VII, 1957, S.322-328)
Vibrio beijerinckii
Vibrio fuscus
Vibrio granii
Vibrio agarliquefaciens
Vibrio purpureus
Pseudomonas iridescens
Pseudomonas gelidicola
Pseudomonas droebachense

(Cytophaga)

References:

Stanier, R.Y.: J.Bacteriol. 42, 527 (1941)

Ishimatsu, K.: Hakko Kogaku Zasshi J. Ferment.Technol. 30, 51 (1952)

DeLaey, M. & L. Massart: Arch.internat.physiol. 64, 127 (1958)

Swartz, M.N. & N. Gordon: J.Bacteriol. 77, 403 (1959)