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October 24, 1974

Dr. J. Niesch
Ciba-Geigy Limited
CH-4002 Basel
Switzerland

Dear Dr. Nilesch,

It was a pleasure to have had a chance to talk to you when
Dr. Cape brought you to our home, I suspect we may also have your
to thank for the gift of some special Penaten cream which we received
in the mail from Switzerland. However, our daughter has been doing very
well now without any special further attention but the opurt of the gift
was certainly most welcome. Shoe

I am writing to you now in resonance with some remarks that you
made about your interest in special enzymes produced by certain
microbial species. I do not recall whether you mentioned the hydrolysis
of agar but it turns out that an efficient agarase, substantially
free of nuclease, would be most helpful in our current laboratory
studies involving the fractionation of DNA by agar electrophoresis.

Our problem is to get effécient recovery of the DNA from specific bands
with non-traumatic treatments. Any help or suggestions that you might
offer us on this score would of course be most deeply appreciated.

I look forward in any event to the possibility of seeing you again
on other matters and remain,

Sincerely yours,

Joshua Lederberg
Professor of Genetics

JL/rr

Pb Meroe. Clin Crp

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