March 25, 1974 Samuel J. Ajl, Ph. D. Vice President For Research The National Foundation March of Dimes 1275 Mamaroneck Avenue White Plains, NY 10605 Dear Dr. Ajl: We respond to your recent announcement seeking research involving only human subjects with the enclosed summary which describes our program for detecting genetic linkage in man. Recently our departments have initiated a long term collaborative effort in human genetics research, and the program described in the summary fs one of the activities that our group is undertaking. The summary was prepared by Howard ¥. Cann, M.D., Associate Professor of Pediatrics and Director of the Genetics Laboratory. One of Dr. Cann's research interests {fs the detection of genetic linkage in man, We are pleased to submit the description of this program for your consideration. Sincerely yours, /ioshua Lederberg, Ph. 0. Chairmangjand Professor Department of Genetics Irving Schulman, 4.0. Chafrmangand Professor Department of Pediatrics JL/TS: rm Enclosure