JUL 2 1971

Proposal for Study of
the Effects of Sickling and the Carrier
‘State of G6PD deficiency in the Population

of the Collaborative Study

‘Principal Investigators:
Dr. N.C. Myrianthopoulos, PRB, NINDS:
Dr. L. Froehlich, PRB, NINDS
Dr. Robert Murray, Howard University

e

Objectives ‘
To study the effects of sickling and of the carrier state of

G6PD deficiency on the course and outcome of pregnancy; and the growth

end development of children with sickle-cell trait, and G6PD deficiency.

Background
Sickle cell anemia and glucose 6 phosphate dehydrogenase (G6PD)

deficiency anemia are two genetically determined hemolytic anemias
found in very high frequency among the Negro population of the United
States. |

7 The gene for S hemoglobin is inherited as an incamplete dominant
60 that the heterozygotes show sickle-cell trait while the homozygotes
have frank anemia. It is estimated that eipproximately 10% of Negroes
in the United States are sicklers while about 3 per 1000 have anemia.

The hazards of sickle-cell anemia are well known: recurrent episodes |

,