DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE
PUBLIC HEALTH SERVICE
NATIONAL INSTITUTES OF HEALTH
BETHESDA, MARYLAND 20014

 

February 10, 1970

Dr. Joshua Lederberg
Stanford University Medical Center
Stanford University School of Medicine
Stanford, California 94305

Dear Joshua:

Since our meeting here last June we have been quite active trying to
implement the recommendations of the panel. A major study of twins is in
progress in collaboration with a group from the University of Minnesota.
We have now developed two proposals to analyze genetically large chunks
of Collaborative Study data. One has to do with a study of the genetics
of obstetric variables and the other with a comprehensive study of con-
genital malformations. I am enclosing copies of these proposals and I

hope that you will be able to review them for merit and give me your
comments and suggestions.

You will be interested to know that late in January the NIMH ad hoc
study section made a site visit in Dr. Lubs! laboratory in connection with
the chromosomal survey of seven year olds from the Collaborative Study.

I was there in a peculiar, in-between capacity, to answer any questions
that the committee might have about the Study. I came away with the
impression that several committee members had misgivings about the uni-
formity of method in the preparation and measurement of specimens, and
also about the method of analysis. I hope that the project will be
approved, otherwise a unique opportunity will be lost.

Let me know when you are going to be in Washington again so that we
can spend some time together,

Yours very sincerely,

Ms

Ntinos C. Myrianthopoulos, Ph.D.

Head, Section on Epidemiology and
Genetics

Perinatal Research Branch

National Institute of Neurological
Diseases and Stroke

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