DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE

 

PUBLIC HEALTH SERVICE _
NATIONAL INSTITUTES OF HEALTH
BETHESDA, MD. 20014 ;
AREA CODE 301 TEL: 656-4000
> May 20, 1969

Dr. Joshua Lederberg

Stanford University Medical Center
Stanford University School of Medicine
Stanford, California 94305

Dear Dr. Lederberg:

——
I am enclosing some background material for our June 19 meeting. In- ==
cluded in this package are, a historical synopsis of the study, the various _"
forms used in the study, frequency distributions and cross tabulations of
important variables, a paper on the socioeconomic index used to describe our .
population and a plan for genetic analysis.
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The two books with the forms were printed before the final 7-year battery
of tests was developed. From this extensive battery I am sending the family
health history form FHH-9, which has been designed to bring up to date the
socioeconomic and genetic information which was collected prenatally on the SE-
and the GEN. 5-8. The tabulations have been produced for the 1959-1964 cohort
which comprises about three quarters of the population. I am sure that this
will give a fair idea of the frequency distribution of the variables in the
population.

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We have developed a socioeconomic index, using the methodology of the
Bureau of the Census, so that we can describe our population and compare it
with the U.S. population. The paper gives the methodology, and a descriptive
and comparative picture of our population.

The plan for genetic analysis was developed by us here, at the request of
my Chief, but it is only a skeleton plan. I hope that the panel will help
modify, supplement or radically change it, and that it will oversee the implemen-
tation of the final product.

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Let us plan to meet at 9:00 a.m. on Thursday, June 19, in my office
which is located in room 720, Wiscon Building, on Wisconsin Avenue and East-
West Highway, about a mile down from the N.I.H. reservation.

Our administrative office will be sending you shortly travel orders and
a TR to purchase your wife's ticket. Please let me know if there is any-
thing else I can do from this end.

My wife and I will be very pleased if you and Mrs. Lederberg could
Join us for supper at our house, 7913 Orchid Street, N. W., Washington,
D. Ce, on the evening of Wednesday, June 18. Please give me a call when
you arrive, either at the office (496-6540) or at home (RA 3-2890) so that
I can arrange transportation for you.

With many thanks and best regards, I am

Very sincerely yours,

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Ntinos C. Myrianthopoulos, Ph.D.

Head, Section on Epidemiology and
Genetics

Perinatal Research Branch

National Institute of Neurological
Diseases and Stroke