OFFICE MEMORANDUM © STANFORD UNIVERSITY @© OFFICE MEMORANDUM e@ STANFORD UNIVERSITY © OFFICE MEMORANDUM

Date: .
May 20, 1968

To: Josh

From : Avram Fo LOS7TET7 /

SusJect: Ccerteing/

Enclosed the reprints of our pubjished work. The Weiss-Laties review
cited by us is the most thorough one I k.iow of, but I am not au courant with

the latest literature, so there mbght be more recent onese

Butcher and Sutherland demonstrated the inhibition of phosphodiesterase
by methytated xanthines (JBC 237: 3244, 1962), which has led to the notion
that caffeine effects, in brain too, might be a result of increased cyclic AMP
levels.

Finally, I have a manuscript in prepara6ion, dealingwith caffeine effects
on coffee=drinkers and noncoffee-drinkers in a housewi-e population at Esoondido
Villagee If you are interested I'd be glad to show you some of the data. It
shov.s clearly that when regular coffee drinkers have a morning cup of coffee
they feel that it wakes them up, makes them fit to face the world, and produces
a certain relaxed eupheriae When they get decaffeinated coffee they feel
miserable and some get headachee Women who never drinkcoffee react very
differently. Coffee makes them jittery, nervous, upset, and upsets their
‘‘stomachs''s Decaffeinated coffee is fine -- none of these negative results
ensuee We'd like to know if these differentiated reactions were present before
the coffee-drinking age, and maybe some day we can find out, but at present we
simply can't tell what is preexisting genetic difference and what is the

consequence of lonyterm adaptation to caffeinee

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