Memo from To: Phil Handler JOSHUA LEDERBERG em 33 TSCA I agree that the legislation, if read as you and I would prefer, responds to the most urgent needs of the research community. But the admini- strator has such enormous latitude-- my concern is how to be sure he is well advised about that flexibility. I would urge you to inquire what advisory mechanisms the EPA intends to employ in setting up its draft regulations and definitions in this area; and my hunch it would be a good idea to establish or instruct a standing committee of the NAS to be sure there is a well-informed group with some authority, ready to speak at short notice, There are always going to be some incidents -- take the Pb (N3)5 that is now a hot issue as an explosive residue -- that can be used as a pretext or focus of pressure for more restrictive approaches, such as ARE within the administrator's discretion. The law is so tricky that any scientific group is going to need very careful briefing to avoid legal and bureaucratic shoals in its arguments. PROFESSOR JOSHUA LEDERBERG Department of Genetics School of Medicine Stanford University Stanford, California 94305