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Carl Dejerassi Chemistry

 

 

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1. I had a good talk with John M. and Dave Rammler today. He

presented a rather imaginative, and for him unusually soundly
thought-out pré@posal for further work, on the displacement of

a specific lipopolysacciharide from bacteria by #DPA, and the con-
comitant sensitization to antibiotics(and uhospnates, etc.) which
are normally kept out. <A great deal of antibiotic-sensitivity-
specificity hangs on this, and he has several very good ideas, tucked
together with somex goo. It is a modest program, with a logical
series of steps, some of which should lead fairly promptly to
product-useful concepts, e.g. the rational choice of chelating
adjuvants to enhance the antibiotic efficacy in topical applications.
The difficult problem may be to keep Dave on a fundamental track,
whih instead of derailing to some 'get-rich-quick' ideas that won8t
rea lly work.

John and I think we can modulate him; he certainly seems to.
have gotten the message.

You should get a properly delimited precis from him via me
shortly. .

2. May I talk to you soon, following ap on your query about

relevenat topics for chemical research, for your students.

I have in mind the chenistry of chloramincs, renerally, (x-NHC1)

about which there is remarkabjy little literature. E.G. Cross-
linking reactions, and other group-substitution effects as influenced
by the chlorine. alan Duffield and balt Patton are pursuing cer-
tain aspects, but have plenty to do with the reactions i:anediately
pertinent to nucleic acid components. and I am sure mechanistic
problems will arise that should be attended to from a broad perspec-
tive. If you are at all interested in natural products in the real
world, which are heavily chlorinated in many environments, you should
get a charge out of this.

 

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