INST. FOR MEDICINSK CELLFORSKNING OCH GENETIK MEDICINSKA NOBELINSTITUTET KAROLINSKA INSTITUTET ee Stockholm, October 1. 1971. Tel. 340560 INSTITUTE FOR MEDICAL CELL RESEARCH AND GENETICS MEDICAL NOBEL INSTITUTE KAROLINSKA INSTITUTET $-104 01 STOCKHOLM 60, SWEDEN Professor Joshua Lederberg School of Medicine Dept. of Genetics Stanford University Stanford Calif. 94305 USA Dear Joshua: The work on chromosome recognition, and now also on the re- cognition of chromosome parts is developing at a tremendous pace at present. New techniques for the study of chromosome structure are ra- pidly coming along and some look promising. The congress for human genetics in Paris a couple of weeks ago showed that a surprisingly great number of laboratories all over the world are already working with the fluorescence techniques and applying them on a variety of fields, human genetics, hybrid studies, phylogenetic studies, Drosophila etc, and our system for classification of the human chromosomes has just been accepted as standard (Rungis, Sept. 1971). Thus we believe it would be useful to have, as soon as possible, a good symposium on the field, to exchange information and to coordi- nate efforts. We are preparing a symposium here in Stockholm on "Recognition of chromosomes and chromosome regions ~- techniques and applications in biology and medicine" (provisional title) planned for 2-3 days and preferably placed at the end of May 1972. A group of 20-25 people is envisaged. This is a preliminary inquiry whether I could impose upon you to participate and - if you are interested - also to contribute some advice. It would be of very special value to have, at the beginning of the symposium, a presentation of more general scope discussing the field and its eventual value in a general way and there is no Professor J. Lederberg October 1. 1971. 2. person better suited for that than you with your wide experience from the entire field of genetics. , We can offer you first class transportation to and from Stock- holm and the costs of living here. Probably the symposium will be one of the "Nobel-symposia" which can be kept on a quite high standard and if that can be arranged in spite of the shortness of the time, we expect to be able to pay for all or most of the invited persons. I will also write Lejeune asking him to comment on the human- genetics-aspects. I expect to have definite information about the technicalities about 2 months from now but would be very grateful for your points of view. With kind personal regards, Vo . Torbj6rn Cas rsson By separate mail I am sending a set of our more recent reprints.