August 4, 1965

Dr. T. Caspersson

Institute for Cell Research
Karolinska Institut
Stockholm 60, Sweden

Dear Torbjorn,

I hope you will recognize the enclosed plots as reduced~scale plots of
the blueprint curves you sent me on the chromosomes of rye.

We used these as exercises for an optical curve~reading program that is

now working on our computer - I think you will agree to considerable satis-
faction. Also enclosed are the printouts from the digitized data as stored
on tape, and as an illustration of a calculation, the computed integral of
each curve.

These were only exercises for us, and I have no intention of doing any
further calculations on these data except at your initiative. However,
if there were any way in which we could be of assistance to you, I would
be delighted to discuss it with you. There are for example statistical
problems of objective classification of the chromosomes from their photo-
metric records. What this does illustrate is she feasibility of storing
and retrieving this kind of data as chart recordings.

Cordially,

Joshua Lederberg
Professor of Genetics

Enclosures:

1 - Tracings (computer-drawn plots)
2 ~ Calculated integrals

3 - Program printout

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Area in sq. inches

19.448
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18.176
21.432
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2h. 352
22. 856
22.448
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235. 42h
16.312
21.752
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25.656