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Memo from To:

JOSHUA LEDERBERG Ralph Dorfman

Syntex
AUG 22 1973

Dear Ralph--

For reasons that include, but go beyond the
fact that Syntex belongs to the AHI, I thought
you would be interested in the enclosed corres-
pondence.

The recommendations are so reactionary that
they will, in my opinion, make it much more diffic
cult to secure rational revisions of the FDA
regulatory philosophy.

I realize there is a wide divergence of
opinion on these matters, and I am certainly
sensitive to well-founded grievances about
existing regulatory abominations. But we should
be careful to discourage over-reacting to these
with extreme positions that are both scientifi-
cally and politically untenable.

I do not suggest that you or Syntex adheres
to the AHI committee's Jine; but as a memher of
AHI, Syntex may become associated with it, and
I would catition about being led into a dangerous
policy trap.

Sincerely,