THE UNIVERSITY OF WISCONSIN
COLLEGE OF AGRICULTURE

Madison 6

DEPARTMENT OF GENETICS March 9, 1959

Dr. Joshua Lederberg
Department of Genetics
Stanford University
School of Medicine
Stanford, California

Dear Josh:

Thank you for your letter of February 9 with the kind comments about the
memo of Jamary 21 to Nathan Smith regarding exchange transfusion, etc.

As yet I have notheard from Smith and frankly I'm too busy right now to
contact him. I'm afraid that it will take an initiative from him to get
this study underway, especially since all we can do here are the laboratory
tests. Any field work mst be done by Smith et al.

I am in complete agreement with your comments about the "fuzziness" of
proposals #4 and 5. They were included as "shotgun" approaches without much
consideration of their practicality.

Becca Patras isn't making much progress on the single cell problem. I ex-
pect to go over her: results within the next few days and decide on the
course to pursue. I'll keep you informed. To keep her happy she has
started to extract substances from RBC's of cattle to get some idea of
the qualitative nature of the antigenic components of the cells. This was
the problem that I wanted to attack when I first came to Wisconsin.

After about a year of "nothing" I decided that a Ph.D. thesis was the
first order of business and that I'd never get one working on the cells.

I'm happy to have her doing this and she seems to have some real promising
approaches to the problem.

“ff TINOLS

Elaine and I still reminisce about the wonderful time we had with you and

Esther on our recent visit to Palo Alto. I can assure you that we will not
miss the next chance to visit you again. Madison is shovelling out of the
worst snow storm in over 25 years. It's horrible. You left just in time!

I hope that you received the "History of Genetics"--six copies were sent
to you several weeks ago.

Write occasionally, we miss you and Esther.
As ever,
Coif

W. H. Stone