$ br hrc. SEP 6 1963

The Lister Institute of Preventive Medicine

Chairman of the Governing Body : CHELSEA BRIDGE ROAD
PROFESSOR SiR CHARLES DODDS, M.V.O., M.D., P.R.C.P., F.R.S. ;

Hon. Treasurer : LONDON, S.W.1.

Sir HuGH BEAVER, K.B.E.

Director : . Telegrams : ‘' Bacteriology, Sowest, London”
PROFESSOR A. A. MILES, C.B.E., M.D., F.R.C.P., F.R.S. Telephone : SLOane 2181

end September, 1963

 

Dear Josh,

Thank you for your letter of July 15. I
assumed thet (as I had expected) there was nothing
suitable/for Subbaiah; he is now more or less fixed
up with Zamenhof, not precisely what he wanted but
it should give him a footing in the transformation

at ie wag @e w MY.

business/ |. Many thanks for your trouble in the

matter,

I enclose a second letter (to facilitate handing

on for action) re reprints ete. of my fla transformation

YAAOOLS

paper which is at long last in proof - somewhat re-
arranged but not much changed in content from the typescript
you had long ago. I feel rather happier about the work
now than I did at the time. Nester & Stocker on latency
etc. also in proof - we had quite a struggle arriving

at a more or less agreed version, partly because Gene

would work in lots of stuff done later - and also after

accepting my stylistic suggestions would re-write!

However you and I have both experienced the difficulty

go tut J Jorbrfcel we Aenteioiy 0 \tomn

fot @— Wrhe out wertin & wilhreomy,
-2-

of trans-atlantic co-authorship!

We are all well, just back from 2 weeks holiday,
more or less vegetating in a cottage near Rye, in Sussex,
English summer nearly at its worst - about as it was
when we drove to Scotland - I am sure you will never
forget the rain at Windsor. However we were comfortable,
Kate and Clare thought everything was marvellous, we
spent much of our time on short expeditions of a touristic
sort to castles etc. - one great advantage of such places
is that villages are pretty close together and nearly
all of them have something worth visiting, in the way
of 14th century churches etc, Rest has done us good,

I am fearfully behind with writing - and have 3 people
writing Ph.D. theses. No sensational news alas - we
find now that i wma? has a specificity absent in i NML ,
earlier negative results due to mis-labelled strain.
Some indication of a fim locus co-transducible with H1
etc. which may clarify some mapping anomalies. I hope
Tino will be visiting after the Hague congress (which

I have skipped). The flagellin chemistry (Malcolm
McDonough) reycalcitrant. Tryptic peptide map of

i NML* now found to differ considerably from that of

i NML” (unexpected, as NML* and NML7 1,2 maps more or
less alike); and the peptide which is shifted in 3

woe/ eee
~3-

serological mutants of i detectable only in the NMLT
mep. Our A-A analyser (EEL model) giving plenty of

trouble,

I have Bob Roantree with me for Sabbatical year -
busy putting nutritional markders into his t-m strain -
we hope to be able to map (pen-r, serum-sensitive) loci
ete. Phil Hartman expected soon, for a few months,
also Helen Makela, We enjoyed seeing the Canns on
the’way back from Milan (we fixed up for them to live
in Rob and Ruth Race's house, they being on holiday) -
and Zindérs on the way to Holland, When shall we
see you again? Grriye mal |

boawe fut hi avy~nvite ® Cnfwite
J Yours sincerely,

+ aytees,  Jlgelin © Jimtrien) h SRD Appr. at May be,
brecting ww WAveunig Dt,
Joe epottid o (lors) rey ecleting ari turret PB re,

>

Gan
HL Deg Mey prene fay Bee stécket Pe Pra 2 Syeter ?

Pour Bghen -ofrd jp Oban vt Weve Ml G00 ne Fig oe

Lane tue 4 Gd he Caley. ii Brea

Professor Joshua Lederberg,

Department of Genetics,

Stanford University School of Medicine,
Stanford Medical Center,

300 Pasteur Drive,

PALO ALTO, CALIF U.S.A.

be foe 9 Opin