October 12, 1953

Dear Bruce:

Yours of the 9th just received. This is better than domestic mail service

es
What is a "letter card"?-- is it this sort of "AIR LRATTER'?

I hope you will not be carrted away in speculation on Larry's High Efficien-
cy of Transduction, The facts are not all settled, but of course they would
point to a reduplication of the whole Lp-Gal segment as part of the phage.

I think this may be a different mechanism from transduction 1n Salmonella.
Lambda grown by the direct kysis of sensitive; bacteria appears to have
little fie any at all!) transducing activity,|whereas lytic and lwoffate
phage from Salmonella are essentially equivalent. To put it a little dif-
ferently, the inclusion of chromosome fragme in Salmonella phages is
accidental; in the K-12/lambda system it is hdt. But Please do not quote
any of this until we are sume of ou AN

     
   
 
   
  
 
   
  
  
  

~.

@ amount of\by 21/-/— (#58.80) plus
§, I have aiso noted "Ship per instruc-—
pre will be no confusion.

I have entered a requisition
cartage for our share of the *¢
tions from Dr. Stocker" so

The story on filtrab
be ag good a system as any;
that would swell snormously
I would not co

y6thes was very fuzzy. PLT22/ LT2 would
“1 recall that the faltrates had granules
a few hours contact with anti-O serum.
presence of viable "cells".

Sincerely,

J Joshua Lederberg