SCHOOL OF MEDICINE UNIVERSITY OF UTAH SALT LAKE CITY 1 LABORATORY FOR THE STUDY OF HEREDITARY AND METABOLIC DISORDERS December 29, 1948 Dr. Joshua Lederberg Department of Genetics College of Agriculture University of Wisconsin Madison 6, Wisconsin Dear Doctor Lederberg: The reprints that you requested are being sent under separate cover. A further develonment of the theory is now in press in the Proceedings of the National Academy of Sciences. I am greatly interested in your studies of the A -2alactosidase. I do not know of any comparable studies on other metal-enzymes. ie have contemplated such a study on leucineaminopeptidase which can utilize both Mn and Mg** but it may be a long time before we can get to it. 8 Lt Z 4 : Emil L. Smith ELS :13 Associate Professor of Biochemistry