sagen

Columbia Gniversity
inthe Citpof Rew Pork

MEW YORK 27, N. Y.

DEPARTMENT OF ZOOLOGY

December 8, 1957

Dear Joshs

At Woods Hole a few summers
ago, you suggested to me a chromosomal mechanisr
to explain the behavior of my non-Mendelizing
strep. resistant mutants. I recall that {
considered at the time that my data overruled
your hypothesis, but now I no longer recall
the hypothesis itself.

If you still do entertain that
view or any other, as an alternative to the
non-chromosomal mechanism which I have pro-
posed, I would apprecaite a note from you
about it, for I am now in the process of
organizing and writing up some recent data on
this system, and I wish to consider all
alternativis which have been suggested.

With best regards to yourself
and Esther,

As ever,

Cal