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July 16, 1962

Dr. Eli Sercarz

Department of Bacteriology and tmaunology
Harvard Medical School

25 Shattuck Street

Boston 15, Massachusetts

Dear Or. Sercarz:
Thank you for your letter of June 25.

We are not continuing any direct work on antibody formation stnce Or.
Nossal's return to Australia. However, | would be happy to hear more
of your specific Interests and qualifications.

Are you thinking only of a permanent position, or rather of further
fellowship work In related fields of molecular blology?

| have some afterthoughts on antibody formation as a postscript (enclosed).
AS, 7 and 8 seem to be the most general statements about the secondary
response, quite apart from the central issue of the original selection or
Instruction process. There are some ambiguities -- plainly there are
stages of maturity, not a sharp separation In two categories. Re A7, It.
seems IIkely that even a mature cell may be repressed If it sees an excess
of antigen. B8ut | do not want to put so much emphasis on this aspect of
antibody formation, as | am more interested in the central issue, A5.

Sincerely yours,

Joshua Lederberg
Professor of Genetics

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