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Department of Medical Genetics

Mayb26, 1957

Dr. E. S. Russell ~
Jackson Laboratory
Bar Harbor, Me.

Dear “Elizabeth:

The question I am going to ask is hardly more than an idha curtosity.

Av' Mitchison mentioned something that suggested you may have done the experi-
ment before the Fire.

Is malanin pigment antigenic? That is to say, is it poasible by repeated
backcrosses to establish black and albino lines of mice isogenic except for

pigmentation; if this has been done, are the lines mutually histocompatible?

My familiarity with the literature in this field is far from profound, but
I hadn't noticed this particular experiment. I would have imagined that there
might be enough odd applications of a pair of isogehic lines of the sort
indioated to justify their production.

With best regards.

Yours sincerely,

Josma Lederberg