UNIVERSIDAD DE CHILE
ESCUELA DE MEDICINA
INSTITUTO DE QUIMICA
FISIOLOGICA Y PATOLOGICA
Borgofio 1470 - Santiago February 10, 1959

 

Dr. Joshua Lederberg
Department of Genetics
Stanford University
stanford, California

Dear Josh:

Thank you for your different correspondence received during the
past weeks and for the help in a number of things.

About four weeks ago I mailed by ship 36 reprints of the paper
"Regulation of ..." They were the last ones, aside of ten for my file. ‘The
number of reprint requests exceeded our calculations,

The correction on the genetic markers of 12244 were transmitted
to the BBActa editor and I hope it will be fixed,

My work in the lab is coming along extremely well, ie found
a strain of ML (MLS) which lacks Monod's permease but has large quantities of
the methyl-beta-galactoside permease. ie are still looking for the other
possible genotypes, especially in K12, The two strains of Gal negatives you
sent me, 5091 and 3092, lack the ability to accumulate methyl-beta~galactoside,
while all the lactose mutants of 112 so far tested accumulate well. It occurred
to me that the methyl-galactoside permease might be the galactose permease which
has a rather wide specificity. If you could send me more strains with different
Gal loci it would be interesting to test if a locus of Gal is connected with
the presence of the permease,

I have rather exciting experiments working with what I call
temporarily an "antipermease" serum, but I prefer to tell you about when the
erucial tests are done. So far is just preliminary stuff.

Give my regards to isther,

 
 

Cle 5
” Boris Rotman