INSTITUTO DE QUIMICA FISIOLOGICA Y PATOLOGICA ESCUELA DE MEDICINA UNIVERSIDAD DE CHILE he Borgofio 1470 - Santiago Dr. J. R. Porter Journal of Bacteriology Medical Laboratories The State University of Iowa Tova City, Iowa Dear Dr, Porter: Please find enclosed a manuscript entitled "Regulation of enzymatic activity in the intact cell, The -galactosidase of Escherichia coli". Iwish to submit this article for your consideration for publication in the Journal of Bacteriology. At the same tine {wish to appoint br. J. Lederberg of the Department of Genetics, University of Viisconsin to handle any further matters with regard to my manuscript. with best rescsards. Sincerely yours, Boris Rotman lincl,