“~) - -
é ' Pebruary 22, 1999.

Dear soreus, ook ; .
While going through ~ reprint files, t notice the gnclosed

reprint, and it struck me that I mat have it by some mistuke, as I
auspect that you loaned it oul to .se sometime long igo axpeoting to
get it back. If this is a duplicat.: copy, I would be pleased to have
it back from you, but unly if you oun spare it. I apologise for having
put my name on it, and for the mistuke.

_ ‘Things are huaming here. vy new lab. has just bean set up, and 4%
is quite comfortable to vork in, Lately, we've found heteroz; ygous diploids
in Kel2, and also 4 cytoplasmic ayaten (4f you vant te call it that) in

the form of lysogenicity. I.%., if the phags lambda is -udded to a sensi-
tivo culture, wany of the cells are lysed, but quite a few nick it up
and grow aymbiotically with it. The interesting noint is that the original
stock Guiture, Kel2, carried lambda in this condition, and that T was
able to detect it only when a sensitive mutant, not carrythy iinbda , appeared,
it can then be transformed back to resistance-lysovenicity. ‘his has
acthing whatever te do with recombination, but looks very parallel to kappa.
Uur gene-enzyme work gets to be more complex than. ever, and for the
. adaptive enzyme iuctuse nothing like 1:1. Gne of cur students has bean working
on Salmonella, to try to find recombination 4n other bactoria > With very —
eacouraging results, except that lysogenicity of one strain for another is
very counon in this a and acts as an “isolating mechanism!®.
| Best regrdas, |